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Di Peng - - 2013
Rosmarinic acid (RA) and lithospermic acid B (LAB) are two typical phenolic acid compounds with significant bioactivities which may contribute to the therapeutic effects of Salvia miltiorrhiza. Precise knowledge of the biosynthetic pathway leading to RA and LAB is a necessary pre-requisite to optimize the production of important phenolic compounds ...
Reiners Christoph - - 2013
Context:After severe reactor emergencies with release of radioactive iodine, elevated thyroid cancer risk in children and adolescents is considered the main health consequence for the population exposed.Design:We studied thyroid cancer outcome after 11.3 years' median follow-up in a selected, very high-risk cohort, 234 Chernobyl-exposed Belarusian children and adolescents undergoing post-surgical ...
Vernon Howard - - 2013
Abstract Purpose: The influence of self-rated disability and fear-avoidance beliefs on whiplash sufferers in their performance of active ranges of motion has not been studied well. We undertook a cross-sectional study to determine this. Methods: Chronic whiplash subjects completed a standard clinical examination. They completed the Neck Disability Index (NDI), ...
Berkefeld Henrike - - 2013
Large conductance Ca(2+)- and voltage-activated potassium channels (BKCa) shape neuronal excitability and signal transduction. This reflects the integrated influences of transmembrane voltage and intracellular calcium concentration ([Ca(2+)]i) that gate the channels. This dual gating has been mainly studied as voltage-triggered gating modulated by defined steady-state [Ca(2+)]i, a paradigm that does ...
Zhang Pei-Pei - - 2013
One new lignan (7S,8R,7'R,8'R)-7-(3,4-methylenedioxyphenyl)-8,8'-dimethyl-8'-hydroxyl-7'-methoxyl-7'-(3',4'-methylenedioxyphenyl)-tetrahydrofuran (1), one new sesquiterpene 2-hydroxy-11,12-dehydrocalamenene (2), one new natural product erythro-1-(3,4-dimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-2,3-dimethyl-butane (3), and two known lignans (+)-anwulignan(erythro-1-(4-hydroxy-3-methoxyphenyl)-4-(3,4-methylenedioxyphenyl)-2,3-dimethyl-butane) (4) and ( - )-zuonin-A (5) were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated by spectroscopic methods. The cytotoxicity of compounds 1 and 2 was assayed.
Thorn Perez Carolina - - 2013
Substance P is endogenously released within the locomotor network of the adult lamprey, accelerates the burst frequency of fictive locomotion and reduces the reciprocal inhibition. Previous studies have shown that dopamine, 5-HT and GABA regulate calcium channels, which control neurotransmitter release, action potential duration and slow afterhyperpolarization. Here we examine ...
Schneider Gabriela G Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Louisville, KY 40202, - - 2013
Evidence suggests that bioactive lipids may regulate pathophysiologic functions such as cancer cell metastasis. Therefore, we determined that the bioactive lipid chemoattractants sphingosine-1-phosphate (S1P) and ceramide-1-phosphate (C1P) strongly enhanced the in vitro motility and adhesion of human rhabdomyosarcoma (RMS) cells. Importantly, this effect was observed at physiologic concentrations for both ...
Yang Hongyan H Semel Institute for Neuroscience & Human Behavior and Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California-Los Angeles, CA 99095, - - 2013
Online microdialysis is a sampling and detection method that enables continuous interrogation of extracellular molecules in freely moving subjects under behaviorally relevant conditions. A majority of recent publications using brain microdialysis in rodents report sample collection times of 20-30 min. These long sampling times are due, in part, to limitations ...
Itoh Kie K Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, - - 2013
Mitochondrial DNA (mtDNA) is packaged into DNA-protein complexes called nucleoids, which are distributed as many small foci in mitochondria. Nucleoids are crucial for the biogenesis and function of mtDNA. Here, using a yeast genetic screen for components that control nucleoid distribution and size, we identify Fcj1 and Mos1, two evolutionarily ...
Chao Ying - - 2013
Scavenger receptors (SRs) are molecular pattern recognition receptors that have been shown to mediate opsonin-independent uptake of therapeutic and imaging nanoparticles, underlying the importance of SRs in nanomedicine. Unlike pathogens, engineered nanomaterials offer great flexibility in control of surface properties, allowing addressing specific questions regarding the molecular mechanisms of nanoparticle ...
Chaudhry Nauman S - - 2013
Over the last quarter century there has been significant progress toward identifying certain characteristics and patterns in GBM patients to predict survival times and outcomes. We sought to identify clinical predictors of survival in GBM patients from the past 24 years. We examined patient survival related to tumor locations, surgical treatment, ...
Pelletier Guillaume - - 2013
Imidazo[1,5-a]azines are synthesized in moderate to excellent yields using a mild cyclodehydration/aromatization reaction triggered by the use of triflic anhydride (Tf2O) and 2-methoxypyridine (2-MeOPyr). Various substitution patterns and functional groups were found to be compatible under the optimized conditions. In addition, a 5-bromo-3-aryl derivative was also shown to be active ...
Chang Huilan - - 2013
Abstract In classical group testing, one is given a population [Formula: see text] and an unknown subset [Formula: see text] of positive items, and the goal is to determine D by testing subsets of [Formula: see text]. Threshold group testing is a generalization of classical group testing, where the outcome ...
Nardo Davide - - 2013
Previous studies on crossmodal spatial orienting typically used simple and stereotyped stimuli in the absence of any meaningful context. This study combined computational models, behavioural measures and functional magnetic resonance imaging to investigate audiovisual spatial interactions in naturalistic settings. We created short videos portraying everyday life situations that included a ...
Truscott Byron J - - 2013
A family of iridium(I)-hydroxides of the form [Ir(cod)(NHC)(OH)] (cod=1,5-cyclooctadiene, NHC=N-heterocyclic carbene) is reported. Single-crystal X-ray analyses and computational methods were used to explore the structural characteristics and steric properties of these new complexes. The model complex [Ir(cod)(IiPr)(OH)] (IiPr=1,3-(diisopropyl)imidazol-2-ylidene) undergoes reaction with a wide variety of substrates including boronic acids and ...
Massey Luke A LA Sara Koe PSP Research Centre, Rita Lila Weston Institute for Neurology Studies and Queen Square Brain Bank, Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK. - - 2013
MRI-based measurements used to diagnose progressive supranuclear palsy (PSP) typically lack pathologic verification and are not easy to use routinely. We aimed to develop in histologically proven disease a simple measure of the midbrain and pons on sagittal MRI to identify PSP. Measurements of the midbrain and pontine base on ...
Olver T Dylan - - 2013
This study tested the hypothesis that acute hyperglycemia reduces sciatic nerve blood flow in Sprague-Dawley rats. Anaesthetized rats underwent cannulation of their right jugular vein (for anaesthetic/nutrient/drug infusion) and right carotid artery (for continuous blood pressure measurement via pressure transducer). The left sciatic nerve was exposed and nerve blood velocity ...
Pires Isabel - - 2013
To evaluate macular thickness in eyes with mild nonproliferative diabetic retinopathy (NPDR), patients with diabetes type 2, NPDR level 20 or 35, and without evidence of clinical macular edema underwent best-corrected visual acuity assessment, color fundus photography and Stratus optical coherence tomography. Mean center point thickness (CPT) and mean central ...
Nicol B - - 2013
In mammals, follistatin (FST) plays an important role in early ovarian differentiation, acting downstream of the Wnt pathway. In teleost fish, fst is implicated in folliculogenesis and oocyte maturation, and an early and specific expression during ovarian differentiation has been described in rainbow trout, Oncorhynchus mykiss. By in situ hybridization, ...
Johnson Ashley A - - 2013
Axonal transport defects and axonopathy are prominent in early preclinical stages of Alzheimer's disease (AD), often preceding known disease-related pathology by over a year. As epigenetic transcriptional regulatory mechanisms, such as histone acetylation, are critical for neurogenesis, it is postulated that their misregulation might be linked to early pathophysiological mechanisms ...
Rosa Vitor - - 2013
New cationic Ag(i) complexes were prepared by reaction of AgBF4 with two thioether-functionalized bis(diphenylphosphino)amine ligands, Ph2PN(p-ArSMe)PPh2 () and Ph2PN(n-PrSMe)PPh2 (), and compared with those obtained from the unfunctionalized ligands Ph2PN(Ph)PPh2 () and Ph2PN(n-Bu)PPh2 (), respectively. The complex [Ag3(μ3-Cl)2(μ2--P,P)3](BF4) (·BF4) contains a triangular array of Ag centres supported by three bridging ...
Huang Feng-Ying - - 2013
Cytochalasin D (CytD) targets actin, a ubiquitous protein in eukaryotic cells. Previous studies have focused mainly on the antitumor effects of CytD. We previously found CytD to promote lung metastasis in B16 melanoma cells, which we had not anticipated, and, therefore, in the present study we investigated the possible underlying mechanisms. ...
Sagan Selena M SM Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA. - - 2013
Hepatitis C virus (HCV) RNA forms an unusual interaction with human microRNA-122 (miR-122) that promotes viral RNA accumulation in cultured human liver cells and in the livers of infected chimpanzees. GB virus B (GBV-B) is a hepatotropic virus and close relative of HCV. Thus, GBV-B has been used as a ...
Sung Jin Yong - - 2013
Purpose:To compare volume reduction of single-session ethanol ablation (EA) and radiofrequency (RF) ablation for cystic thyroid nodule treatment.Materials and Methods:All patients gave written informed consent to participate in this prospective institutional review board-approved study. From May 6, 2010, to August 8, 2011, in this single-institutional, noninferiority trial, 50 patients, each ...
Winichayakul Somrutai - - 2013
Our dependency on reduced carbon for energy has led to a rapid increase in the search for sustainable alternatives and a call to focus on energy densification and increasing biomass yields. In this study we generated a uniquely stabilised plant structural protein (cysteine-oleosin) that encapsulates triacylglycerol (TAG). When co-expressed with ...
Anginot Adrienne A Centre d'Immunologie de Marseille-Luminy, Faculté des Sciences de Luminy, Aix Marseille University, UM2, Marseille F-13288, France. - - 2013
Galectin-1 (GAL1) is an S-type lectin with multiple functions, including the control of B cell homeostasis. GAL1 expression was reported to be under the control of the plasma cell master regulator BLIMP-1. GAL1 was detected at the protein level in LPS-stimulated B cells and was shown to promote Ig secretion ...
Kar Parimal - - 2013
Both KNI-10033 and KNI-10075 are high affinity preclinical HIV-1 protease (PR) inhibitors with affinities in the picomolar range. In this work, the molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) method has been used to investigate the potency of these two HIV-1 PR inhibitors against the wild-type and mutated proteases assuming that ...
Ehrich Kathryn - - 2013
BACKGROUND: Early stage clinical innovation often occurs 'under the radar' of governance systems for established procedures. Previously impossible or unavailable techniques still being developed involve additional uncertainty and unknown risks and benefits compared with standard procedures. Patient and family expectations, perceptions and experiences of these new procedures and their possible ...
Koch Kathrin - - 2013
Individual responsiveness to rewards or rewarding stimuli may affect various domains of normal as well as pathological behavior. The ventral striatum/nucleus accumbens (NAcc) constitutes a key brain structure in the regulation of reward-appetitive behavior. It remains unclear, however, to which extent individual reward-related BOLD response in the NAcc is dependent ...
Shi Huoying - - 2013
We developed the regulated delayed attenuation strategies for Salmonella vaccine vectors. In this study, we evaluated the combination of these strategies in recombinant attenuated S. Typhi and S. Typhimurium vaccine vectors with similar genetic background in vitro and in vivo. Our goal is to develop a vaccine to prevent Streptococcus ...
Pussak Daniel - - 2013
Elastic sensors: A simple method is presented for the measurement of specific biomolecular interactions with soft colloidal hydrogel particles (SCPs) as sensors. Carbohydrate/lectin interactions (see picture; green: carbohydrate molecules) were studied by optical detection of the mechanical deformation of the particles on a lectin surface. The affinity of various carbohydrate ...
Racoosin Judith A - - 2013
During the past 10 years, efforts in pharmacogenomics have generated insights into the efficacy and safety of drugs, enhancing our understanding of the safety profile of even some of the oldest drugs, such as codeine sulfate, an opioid analgesic first approved in 1950 for relief of mild or moderate pain. ...
Castiglioni Sara - - 2013
The contribution of magnesium to cell differentiation is not clear. Some studies indicate that low extracellular magnesium promotes cell differentiation, while others reach opposite conclusions. We evaluated the effects of different concentrations of extracellular magnesium on the differentiation of three in vitro experimental models: human endothelial cells seeded onto Matrigel; ...
Kanzawa Maki - - 2013
Objective: Direct interaction with cancer-associated fibroblasts triggers WNT5A expression in human gastric carcinoma (GC) cells. In this study, we performed gene transduction experiments to investigate the significance of WNT5A in the GC tumor microenvironment. Methods: Gene transduction (pWNT5A and shWNT5A) was performed in human GC-derived MKN-7 cells. Altered gene expression ...
Macaulay Catrin E - - 2013
We evaluated the cognitive development of 48 profoundly deaf children from hearing families (born 1994-2002, mean age M = 8.0 years at time of test, none of whom had received early auditory-verbal therapy) as a function of family socioeconomic status and number of siblings. Overall, the deaf children matched a ...
López-Sánchez Noelia - - 2013
A subpopulation of chick retinal projection neurons becomes tetraploid during development, an event prevented by blocking antibodies against p75 neurotrophin receptor (p75(NTR)). We have used an optimized flow cytometric assay, based on the analysis of unfixed brain cell nuclei, to study whether p75(NTR)-dependent neuronal tetraploidization takes place in the cerebral ...
Bonekamp Susanne S Russell H. Morgan Department of Radiology and Radiological Science and Department of Surgery and Oncology, The Johns Hopkins Hospital, 600 N Wolfe St, MRI 143, Baltimore, MD 21287, - - 2013
To identify and validate the optimal thresholds for volumetric functional MR imaging response criteria to predict overall survival after intraarterial treatment (IAT) in patients with unresectable hepatocellular carcinoma (HCC). Institutional review board approval and waiver of informed consent were obtained. A total of 143 patients who had undergone MR imaging ...
Mehrnia Mohammad M Max-Planck Institute of Molecular Plant Physiology, Cooperative Research Group, D-14476 Golm/Potsdam, - - 2013
We report about ERF BUD ENHANCER (EBE; At5g61890), a transcription factor that affects cell proliferation as well as axillary bud outgrowth and shoot branching in Arabidopsis (Arabidopsis thaliana). EBE encodes a member of the APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF) transcription factor superfamily; the gene is strongly expressed in proliferating cells and ...
Xu Miduo - - 2013
Although modifier genes are extensively studied in various diseases, little is known about modifier genes that regulate autoimmune diseases. Autoimmune disease caused by the Fas(lpr) mutation depends on the genetic background of mouse strains, suggesting a crucial role of modifier genes. MRL/MpJ-Fas(lpr) (MRL/lpr) and AKR/lpr mice develop severe and mild ...
Evers Christina - - 2013
Craniofrontonasal syndrome (CFNS) is an X-linked disorder caused by inactivating mutations in the gene for ephrin-B1 (EFNB1). Paradoxically it shows a more severe phenotype in females than in males. As a result of X inactivation cell populations with and without EFNB1 expression are found in EFNB1+/- females. This is thought ...
Wang Hong - - 2013
The core-shell nanoparticle structure, which consists of an inner layer "guest" nanoparticle encapsulated inside another of a different material, is the simplest motif in two-component systems. In comparison to the conventional single-component systems, complex systems pose both challenges and opportunities. In this Account, we describe our recent progresses in using ...
Posch Gerald - - 2013
Tannerella forsythia is a Gram-negative anaerobic organism that inhabits subgingival plaque biofilms and is covered with a so far unique surface(S-) layer composed of two glycoproteins. It belongs to the so-called 'red complex' of bacteria comprising species that are associated with periodontal disease. While the S-layer glycoprotein glycan structure had ...
Fernando Irosh - - 2013
OBJECTIVE: Clinical reasoning in psychiatry may be considered to be more challenging than in other branches of medicine because of its highly subjective nature. The literature on systematic approaches to the teaching of clinical reasoning in psychiatry is lacking, and we propose an approach that may assist educators and learners. ...
Bowyer Paul - - 2013
Fungal diseases are problematic in both human health and agriculture. Treatment options are limited and resistance may emerge. The relatively recent recognition of triazole resistance in Aspergillus fumigatus has prompted questioning of the origin of resistance. While multiple mechanisms are described in clinical isolates from triazole-treated patients, some de novo ...
Lyles Christopher N - - 2013
Ultra-low sulfur diesel (ULSD) fuel has been integrated into the worldwide fuel infrastructure to help meet a variety of environmental regulations. However, desulfurization alters the properties of diesel fuel in ways that could potentially impact its biological stability. Fuel desulfurization might predispose ULSD to biodeterioration relative to sulfur-rich fuels, and ...
Bhalla Vandana - - 2013
Spherical aggregates of hexaphenylbenzene derivative 5 undergo metal-induced modulation to form nanorods in the presence of Hg(2+) ions, which exhibit selective and sensitive response toward picric acid (PA) with a detection limit of 6.87 ppb.
Wang An-Li AL Annenberg Public Policy Center, Department of Psychiatry, and Annenberg School for Communication, University of Pennsylvania, Philadelphia, Pennsylvania 19104, - - 2013
Televised public service announcements are video ads that are a key component of public health campaigns against smoking. Understanding the neurophysiological correlates of anti-tobacco ads is an important step toward novel objective methods of their evaluation and design. In the present study, we used functional magnetic resonance imaging (fMRI) to ...
Hochreiter-Hufford Amelia E AE Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908, - - 2013
Skeletal muscle arises from the fusion of precursor myoblasts into multinucleated myofibres. Although conserved transcription factors and signalling proteins involved in myogenesis have been identified, upstream regulators are less well understood. Here we report an unexpected discovery that the membrane protein BAI1, previously linked to recognition of apoptotic cells by ...
Liang Jing Nong - - 2013
Following stroke, hemiparesis results in impaired motor control. Specifically, inappropriate direction of foot-forces during locomotion has been reported. In our previous study that examined post-stroke foot-force direction during a seated, supported locomotor task, we observed that foot-force control capabilities were preserved post-stroke. In this current study, we sought to better ...
Chandan Payal A - - 2013
Amine assisted CO2 Amine assisted CO2 capture process from the coal fired power plant strives for the determination of degradation components and its consequences. Among them, nitrosamine formation and their emissions are of particular concern due to their environmental and health effects. The experiments were conducted using morpholine as a ...
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