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Hisamatsu Takeshi T Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, - - 2013
The goal of this study was to examine the role of mTOR complex 2 (mTORC2) as a therapeutic target in ovarian clear cell carcinoma (CCC), which is regarded as an aggressive, chemoresistant histologic subtype. Using tissue microarrays of 98 primary ovarian cancers [52 CCCs and 46 serous adenocarcinomas (SAC)], activation ...
Chebrek Safia - - 2013
Abstract We evaluated the prevalence of primary pulmonary hypertension (PHT) in patients with chronic myeloproliferative neoplasms (MPN) in a large series of 103 patients. In sharp contrast with the literature, we found a prevalence of 5% instead of the surprisingly high previously reported prevalence of 38%. That may reflect a ...
Sanz Sílvia S Barcelona Centre for International Health Research, Hospital Clínic-Universitat de Barcelona, CEK, 1a Planta, Rosselló 149-153, 08036, Barcelona, - - 2013
Carbohydrate structures play important roles in many biological processes, including cell adhesion, cell-cell communication, and host-pathogen interactions. Sugar nucleotides are activated forms of sugars used by the cell as donors for most glycosylation reactions. Using a liquid chromatography-tandem mass spectrometry-based method, we identified and quantified the pools of UDP-glucose, UDP-galactose, ...
Gao Yuyan - - 2013
The connection between inflammation and colorectal cancer (CRC) has been well recognized, and numerous related molecular mechanisms have been uncovered. To gain further insight, we used BALB/c mice treated with azoxymethane (AOM) and dextran sulfate sodium salt (DSS) to establish a colitis-associated CRC model recapitulating tubulovillous adenoma with high-grade dysplasia ...
Menon Vipin Kumar VK Department of Gastrointestinal Sciences, Christian Medical College, Vellore, - - 2013
Human and bovine norovirus virus-like particles were used to evaluate antibodies in Indian children at ages 6 and 36 months and their mothers. Antibodies to genogroup II viruses were acquired early and were more prevalent than antibodies to genogroup I. Low levels of IgG antibodies against bovine noroviruses indicate possible ...
Goodwin Meredith Rumon - - 2013
Advances in the surgical approach to thoracic aortic aneurysm repairs have led to the increasing use of one-lung ventilation. Today's practice of cardiothoracic and vascular anesthesia requires a clear understanding of the techniques available for lung separation and the technical skills necessary to employ them. In this article, we discuss ...
Manna Arun K - - 2013
First-principles DFT calculations are carried out to study the changes in structures and electronic properties of two-dimensional single-layer graphene in the presence of non-covalent interactions induced by carbon and boron fullerenes (C60 , C70 , C80 and B80 ). Our study shows that larger carbon fullerene interacts more strongly than ...
Manfrinati Andrea - - 2013
Traditional studies on moral judgement used resolutions of moral dilemmas that were framed in terms of acceptability of the consequentialist action promoting a greater good, thus overlooking the deontological implications (choices cannot be justified by their consequences). Recently, some authors have suggested a parallelism between automatic, unreflective emotional responses and ...
Liu Chao - - 2013
The WEE1 kinase family has been shown to be the major kinase family responsible for phosphorylating Tyr 15 on cyclin-dependent kinase 1 (CDK1). WEE1 homolog 2 (WEE2, also known as WEE1B) was first identified in Xenopus laevis and more recently in humans and mice, and is responsible for phosphorylating the CDK1 inhibitory site ...
Manolova Irena - - 2013
Background: Transforming growth factor-β1 (TGF-β1) exerts broad anti-inflammatory and immunosuppressive effects and plays a key role in self-tolerance. Complete knockout of TGF-β1 in mice results in autoimmunity and multi-organ inflammatory syndrome. The aim of the present study was to determine TGF-β1 serum levels in healthy individuals and in patients with ...
Tanos Tamara T Swiss Institute for Experimental Cancer Research, National Center of Competence in Research Molecular Oncology, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, - - 2013
Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor κB ligand (RANKL) has been identified as a pivotal paracrine mediator of progesterone ...
Schmidt Moritz - - 2013
We present a comprehensive study of the solid solution system Ca2(MoO4)2-NaGd(MoO4)2 on the molecular scale, by means of site-selective time resolved laser fluorescence spectroscopy (TRLFS). Eu(3+) is used as a trace fluorescent probe, homogeneously substituting for Gd(3+) in the solid solution crystal structure. Site-selective TRLFS of a series of polycrystalline ...
Müller-Oehring E M EM Neuroscience Program, Center Health Science, SRI International, Menlo Park, CA, USA. - - 2013
Alcohol dependence is associated with impaired control over emotionally motivated actions, possibly associated with abnormalities in the frontoparietal executive control network and midbrain nodes of the reward network associated with automatic attention. To identify differences in the neural response to alcohol-related word stimuli, 26 chronic alcoholics (ALC) and 26 healthy ...
Wada Takehiko - - 2013
The complement system functions as a part of the innate immune system. Inappropriate activation of the complement pathways has a deleterious effect on kidneys. Recent advances in complement research have provided new insights into the pathogenesis of glomerular and tubulointerstitial injury associated with complement activation. A new disease entity termed ...
Jouhet V - - 2013
Objective: The aim of this study was to develop and evaluate a selection algorithm of relevant records for the notification of incident cases of cancer on the basis of the individual data available in a multi-sourceinformation system. Methods: This work was conducted on data for the year 2008 in the ...
Filiberto Amanda C AC Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD, - - 2013
Isoflavones have been associated with lower cardiovascular disease risk, but existing research focused on very high isoflavone intakes, as seen in Asian populations, as well as on risk factor reductions primarily in postmenopausal women. We investigated whether habitual low isoflavone intake among premenopausal women was associated with serum C-reactive protein ...
Jiang Xue X Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United - - 2013
A hallmark of severe Lassa fever is the generalized immune suppression, the mechanism of which is poorly understood. Lassa virus (LASV) nucleoprotein (NP) is the only known 3'-5' exoribonuclease that can suppress type I interferon (IFN) production possibly by degrading immune-stimulatory RNAs. How this unique enzymatic activity of LASV NP ...
Hu Lili - - 2013
From the photofragment translational spectra of C-H symmetric stretch excited CH3I [v1 = 1, v2 = 0] photodissociatioin at 277.5 nm, the vibrational distribution of photofragments CH3 (v1 = 0, v2 = 0), (0, 1), (1, 0), (1, 1) in the I* channel are measured to be 0.02, 0.02, 0.47, ...
Tercel Moana - - 2013
The answer lies in the DNA: Recent claims that the alkylation of a particular protein contributes to the cytotoxicity of the duocarmycins could not be substantiated. The evidence, like the fluorescent signal derived from a clickable analogue, points instead to a reaction occurring in the nucleus.
Hall Anthony Shoji - - 2013
By combining nanosphere lithography with template stripping, silicon wafers were patterned with hexagonal arrays of nanowells or pillars. These silicon masters were then replicated in gold by metal evaporation, resulting in wafer-scale hexagonal gratings for plasmonic applications. In the nanosphere lithography step, two-dimensional colloidal crystals of 510 nm diameter polystyrene ...
Li Yaqiong - - 2013
The absorption and fluorescence spectra of chlorophyll f (newly discovered in 2010) have been measured in acetone and methanol at different temperatures. The spectral analysis and assignment are compared with the spectra of chlorophyll a and d at the same experimental conditions. The spectroscopic properties of these chlorophylls have further ...
Pizzirani Daniela - - 2013
Acid ceramidase (AC) is an intracellular cysteine amidase that catalyzes the hydrolysis of the lipid messenger ceramide. By regulating ceramide levels in cells, AC may contribute to the regulation of cancer cell proliferation and senescence and to the response to cancer therapy. We recently identified the antitumoral agent carmofur (4a) ...
Brock William J - - 2013
The eye is a unique sensory structure, which must be evaluated for toxicity to determine the safety of drugs, industrial chemicals, and consumer products. Changes in the structure and/or function of ocular tissues following systemic administration of a potential new drug in preclinical animal models can result in significant delays ...
Kristensen Hanne Kaae - - 2013
Abstract Aim: Studies have shown that evidence-based practice improves outcomes, both for patients and for staff organisational systems. However, the incorporation of evidence-based guidelines in a health care practice requires a specific, targeted approach on all organisational levels. Purpose: To gain a deeper understanding of how to facilitate the implementation ...
Zhang Kai K Department of Chemistry, Stanford University, Stanford, California 94305, - - 2013
Retrograde trophic signaling of nerve growth factor (NGF) supports neuronal survival and differentiation. Dysregulated trophic signaling could lead to various neurological disorders. Charcot-Marie-Tooth type 2B (CMT2B) is one of the most common inherited peripheral neuropathies characterized by severe terminal axonal loss. Genetic analysis of human CMT2B patients has revealed four ...
Mänz Benjamin B Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, - - 2013
Avian influenza A viruses, such as the highly pathogenic avian H5N1 viruses, sporadically enter the human population but often do not transmit between individuals. In rare cases, however, they establish a new lineage in humans. In addition to well-characterized barriers to cell entry, one major hurdle which avian viruses must ...
Gan Zibao - - 2013
Bifunctional Au-loaded Fe3O4@C composite microspheres were controllably synthesized by coating of Au nanoparticles (NPs) on the surface of the poly(diallyldimethylammonium chloride) (PDDA) functionalized Fe3O4@C microspheres. The amount of Au loading can be effectively tuned by altering the feeding amounts of solution Au NPs or further growth. The obtained Au-loaded Fe3O4@C ...
Del Re Julia - - 2013
We observe changes in the molecular conductivity of individual oligophenylene-vinylene (OPV) molecules due to interactions with small aromatic molecules. Fluorescence experiments were correlated with scanning tunneling microscopy measurements in order to determine the origin of the observed effect. Both nitrobenzene and 1,4-dinitrobenzene decreased fluorescence intensity and molecular conductivity, while toluene ...
Ter Laan M - - 2013
Cerebral blood flow (CBF) is regulated by vasomotor, chemical, metabolic, and neurogenic mechanisms. Even though the innervation of cerebral arteries is quite extensively described and reviewed in the literature, its role in regulation of CBF in humans remains controversial. We believe that insufficient attention has so far been focused on ...
Ellen J M - - 2013
To determine effectiveness of alternate venue testing (AVT), social network strategy (SNS) and provider referral (PR) for identifying previously undiagnosed HIV-infected 18-64-year-old African American men who have sex with men (AA MSM) by a health department. For AVT, staff used a mobile clinic to conduct HIV testing. For PR, staff ...
Simon A - - 2013
More than 80% of all paediatric oncology patients have a long term central -catheter (CVAD; port or Broviac type). Many aspects considering the use of CVADs have not been studied.Children and adolescents treated in Paediatric Oncology centres.Internet-based multicentre survey related to the use of CVADs conducted in cooperation with the ...
Baker Laura K - - 2013
Desmin intermediate filaments (DIFs) form an intricate meshwork that organizes myofibers within striated muscle cells. The mechanisms that regulate the association of desmin to sarcomeres and their role in desminopathy remain incompletely understood. Here, we compare the effect nebulin binding has on the assembly kinetics of desmin and three desminopathy-causing ...
Vickers Chris J - - 2013
Caspases are required for essential biological functions, most notably apoptosis and pyroptosis, but also cytokine production, cell proliferation, and differentiation. One of the most well studied members of this cysteine protease family includes executioner caspase-3, which plays a central role in cell apoptosis and differentiation. Unfortunately, there exists a dearth ...
Tang Wei - - 2013
Aim: While hydroxyapatite nanoparticles (HAPNs) have been reported to exhibit anticancer effects on several types of human cancer cells, no investigation has been performed to compare their cytotoxicity with different types of cancer cells. The objective of the present study is to investigate the cytotoxic action of HAPNs in different ...
Zhang Junping - - 2013
A facile method for the preparation of silica/silicone nanofilament hybrid coatings with almost perfect superhydrophobicity (contact angle=179.8° and sliding angle=1.3°) is presented. The coatings are obtained by dip-coating of silica nanoparticles, followed by chemical vapor deposition of silicone nanofilaments. Predominant growth of silicone nanofilaments onto aggregated silica nanoparticles generates a ...
Arnold Amy C AC Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, - - 2013
To determine the effect of low-dose propranolol on maximal exercise capacity in patients with postural tachycardia syndrome (POTS). We compared the effect of placebo vs a single low dose of propranolol (20 mg) on peak oxygen consumption (VO2max), an established measure of exercise capacity, in 11 patients with POTS and ...
Neumann Claas L - - 2013
Abstract Lacking compliance with liquid intake restrictions is one of the major problems in patients on hemodialysis and causes an increased mortality. In 120 patients on hemodialysis with an average interdialytic weight gain (IWG) exceeding 1.5 kg on at least 2 days during the 4 weeks preceding the intervention, the effect ...
Leoni S - - 2013
Purpose: To assess the impact of different vascular patterns at contrast-enhanced ultrasound (CEUS) on the characterization of small liver nodules (10 - 30 mm) in cirrhosis and to determine whether primary nodules and recurrent nodules (after a previously treated hepatocellular carcinoma) display variations in enhancement pattern.Materials and Methods: A total ...
Philips Gary T GT Center for Neural Science, New York University, New York, New York 10003, - - 2013
Although the importance of spaced training trials in the formation of long-term memory (LTM) is widely appreciated, surprisingly little is known about the molecular mechanisms that support interactions between individual trials. The intertrial dynamics of ERK/MAPK activation have recently been correlated with effective training patterns for LTM. However, whether and ...
Hu Jie - - 2013
The mechanism of mesenchymal stem cell therapy in acute kidney injury remains uncertain. Previous studies indicated that mesenchymal stem cells could attenuate inflammation-related organ injury by induction of regulatory T cells. Whether regulatory T-cell induction is a potential mechanism of mesenchymal stem cell therapy in ischemic acute kidney injury and ...
Song Yan Y Department of Epidemiology and Program on Genomics and Nutrition, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, - - 2013
Dietary factors, including dietary fat, may affect the biological aging process, as reflected by the shortening of telomere length (TL), by affecting levels of oxidative stress and inflammatory responses. We examined the direct relations of total and types of dietary fats and fat-rich foods to peripheral leukocyte TL. In 4029 ...
Feng Lei L Center for Retrovirus Research, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, - - 2013
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a very promising new class of anti-HIV-1 agents that exhibit a multimodal mechanism of action by allosterically modulating IN multimerization and interfering with IN-lens epithelium-derived growth factor (LEDGF)/p75 binding. Selection of viral strains under ALLINI pressure has revealed an A128T substitution in HIV-1 ...
Lam Virginie - - 2013
BACKGROUND: Ionized calcium (iCa) is the biologically active form of this micronutrient. Serum determination of iCa is measured via ion-electrode potentiometry (IEP) and reporting iCa relative to pH 7.4 is normally utilized to avoid the potential confounding effects of ex vivo changes to serum pH. Adjustment of iCa for pH ...
Genovese Damiano - - 2013
Stars that shine bright: A high local dye concentration in doped silica-based core-shell nanoparticles causes self-quenching and spectral broadening (top images). This phenomenon jeopardizes the potential advantages of heavily doped systems. Förster resonance energy transfer (FRET) to an acceptor co-included in the silica led to ultrabright nanoparticles (bottom images) with ...
Kadakkuzha Beena M BM Department of Neuroscience, The Scripps Research Institute, Scripps Florida 130 Scripps Way, Jupiter, FL 33458, - - 2013
The human brain is extraordinarily complex, composed of billions of neurons and trillions of synaptic connections. Neurons are organized into circuit assemblies that are modulated by specific interneurons and non-neuronal cells, such as glia and astrocytes. Data on human genome sequences predicts that each of these cells in the human ...
Basavaraju K C - - 2013
Putting osmium in its place: The immobilization of hazardous OsO4 on polymer nanobrushes in a microreactor is a safe, effective, and green concept. The method allows reactions to be performed in a time- and chemical-saving manner, with little environmental impact, as compared to spill-over bulk processes.
Cashman Kevin D KD School of Food and Nutritional Sciences, University College Cork, Cork, Ireland. - - 2013
The Vitamin D Standardization Program (VDSP) has developed protocols for standardizing procedures of 25-hydroxyvitamin D [25(OH)D] measurement in National Health/Nutrition Surveys to promote 25(OH)D measurements that are accurate and comparable over time, location, and laboratory procedure to improve public health practice. We applied VDSP protocols to existing ELISA-derived serum 25(OH)D ...
Li Yan - - 2013
Humic substances (HS), including humic acids (HA) and fulvic acids (FA), are important components of soil systems. HS form strong complexes with oppositely charged proteins, which will lead to changes in the enzyme activity. The effect of soil HS on the activity and stability of two enzymes was investigated as ...
Takahashi Kayoko - - 2013
Lymph node metastasis is the most important prognostic factor of endometrial cancer. However, effective therapy has not been established against lymph node metastasis. In this study, we explored the efficacy of gene therapy targeting lymph node metastasis of endometrial cancer by suppressing the action of vascular endothelial growth factor (VEGF)-C ...
Choi Seong-Woo - - 2013
Background: Kidney dysfunction and albuminuria may be associated with BMD. However, little evidence has been reported on relationships between BMD and eGFR and albuminuria. Methods: A total of 8,992 subjects aged 50 years or older participated in a survey conducted. Participants had their lumbar spine and femoral neck BMD measured ...
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