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Klemme Sonja - - 2013
B chromosomes (Bs) are supernumerary chromosomes that vary in number among individuals of the same species. Because of their dispensable nature, their non-Mendelian inheritance and their origin from A chromosomes (As), one might assume that Bs followed a different evolutionary pathway from As, this being reflected in differences in their ...
Mellqvist Ulf-Henrik - - 2013
The Nordic Myeloma Study Group (NMSG) conducted an open randomized trial to compare bortezomib as consolidation therapy given after high-dose therapy (HDT) and autologous stem cell transplantation (ASCT) to no consolidation in bortezomib naïve patients with newly diagnosed multiple myeloma. Overall, 370 patients were centrally randomly assigned three months after ...
Franco Andrea A Division of Monoclonal Antibodies, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, - - 2013
Fc receptor-like (FCRL) 5 regulates B cell Ag receptor signaling and has been reported to bind aggregated IgG. Using surface plasmon resonance, we analyzed the interaction of native IgG samples with FCRL5, revealing a complex binding mechanism, where isotype is just one factor. FCRL5 bound IgG1 and IgG4 with ~1 ...
Te Raa G D - - 2013
Abstract The ATM-p53 DNA damage response pathway plays a crucial role in chemoresistance in chronic lymphocytic leukemia, as indicated by the adverse prognostic impact of deletions of 17p (locus of TP53) and 11q (locus of ATM) detected by FISH analysis. In addition to deletions, mutations in these respective genes are ...
Gokulan Kuppan K Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, - - 2013
PKS11 is one of three type III polyketide synthases (PKSs) identified in Mycobacterium tuberculosis. Although many PKSs in M. tuberculosis have been implicated in producing complex cell wall glycolipids, the biological function of PKS11 is unknown. PKS11 has previously been proposed to synthesize alkylpyrones from fatty acid substrates. We solved ...
Bugaighis I - - 2013
Objectives :  The aim of this study was to characterize three-dimensional (3D) facial morphological variation of children with cleft lip and palate compared to an age- and sex-matched control group. Design :  Cross-sectional, case-controlled observational morphometric study. Materials and Methods :  Subjects were 103 children aged 8 to 12 years ...
Villellas Cristina C Departamento de Microbiología, Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Zaragoza, Zaragoza, - - 2013
The Mycobacterium tuberculosis pandemic is a major health problem, further complicated by an increasing incidence of drug-resistant isolates and the existence of highly transmissible strains, such as those in the Beijing family. Streptomycin (STR)-resistant M. tuberculosis clinical isolates have been analyzed to look for mutations in the rpsL, rrs, and ...
Powell Mark R - - 2013
Much of the literature regarding food safety sampling plans implicitly assumes that all lots entering commerce are tested. In practice, however, only a fraction of lots may be tested due to a budget constraint. In such a case, there is a tradeoff between the number of lots tested and the ...
Wang Dengjun - - 2013
Biochar land application may result in multiple agronomic and environmental benefits (e.g., carbon sequestration, improving soil quality, and immobilizing environmental contaminants). However, our understanding of biochar particle transport is largely unknown in natural environment with significant heterogeneity in solid (e.g., patches of iron oxyhydroxide coating) and solution chemistry (e.g., the ...
Bugdalski Lauren - - 2013
Soil lead pollution is a recalcitrant problem in urban areas resulting from a combination of historical residential, industrial, and transportation practices. The emergence of urban gardening movements in postindustrial cities necessitates accurate assessment of soil lead levels to ensure safe gardening. In this study, we examined small-scale spatial variability of ...
Hauk Olaf - - 2013
Brain activation estimated from EEG and MEG data is the basis for a number of time-series analyses. In these applications, it is essential to minimize "leakage" or "cross-talk" of the estimates among brain areas. Here, we present a novel framework that allows the design of flexible cross-talk functions (DeFleCT), combining ...
Le Xiuning X Stem Cell Program and Division of Hematology/Oncology, Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, - - 2013
The zebrafish is a powerful genetic model that has only recently been used to dissect developmental pathways involved in oncogenesis. We hypothesized that operative pathways during embryogenesis would also be used for oncogenesis. In an effort to define RAS target genes during embryogenesis, gene expression was evaluated in Tg(hsp70-HRAS(G12V)) zebrafish ...
Hallock Geoffrey G - - 2013
Even though the pectoralis major muscle has many similarities to the latissimus dorsi muscle, only the latter has a reputation as a "workhorse" free flap. Nevertheless, the former in special circumstances can provide a muscle flap of comparable surface area when used in its totality along with a skin paddle, ...
Nieland Anja - - 2013
A new class of rare-earth-metal alkynyl complexes has been prepared. The reactions of the tris(tetramethylaluminate)s of lanthanum, praseodymium, samarium, yttrium, holmium, and thulium, [Ln(AlMe4 )3 ], with phenylacetylene afforded compounds [Ln{(μ-CCPh)2 AlMe2 }3 ] (Ln=La (1), Pr (2), Sm (3), Y (4), Ho (5), Tm (6)). All of these compounds ...
Meng L - - 2013
There is currently no consensus regarding how to intervene in anaesthetic-induced hypotension. Whether or not the balance between cerebral oxygen supply and demand is maintained lacks adequate elucidation. It is thus intriguing to explore how cerebral tissue oxygen saturation is affected by anaesthetic-induced hypotension. Thirty-three patients scheduled for elective non-neurosurgical ...
Uchimura Motoaki - - 2013
Many previous studies have reported that our brains are able to encode a target position not only in body-centered coordinates but also in terms of landmarks in the background. The importance of such allocentric memory increases when we are forced to complete a delayed reaching task after the target has ...
Parker Whitney E - - 2013
A rare neurodevelopmental disorder in the Old Order Mennonite population called PMSE (polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome; also called Pretzel syndrome) is characterized by infantile-onset epilepsy, neurocognitive delay, craniofacial dysmorphism, and histopathological evidence of heterotopic neurons in subcortical white matter and subependymal regions. PMSE is caused by a homozygous ...
Liu Lu - - 2013
A Sc(OTf)3-catalyzed three-component cyclization reaction of arylamines, beta, gamma-unsaturated alpha-ketoesters and 1,3-dicarbonyl compounds was developed to synthesize highly substituted 1,4-dihydropyridines and fused bicyclic tetrahydropyridines carrying a quaternary all-carbon center.
Liu Haiying - - 2013
A highly water-soluble BODIPY dye bearing electron-rich o-diaminophenyl groups at 2,6-positions was prepared as a highly sensitive and selective fluorescent probe for detection of nitric oxide (NO) in living cells. The fluorescent probe displays an extremely weak fluorescence with fluorescence quantum yield of 0.001 in 10 mM phosphate buffer (pH ...
Chen Hai-yan HY Department of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, - - 2013
The purpose of this investigation was to analyze the correlation between CT size and gross pathologic size for subjects with primary hepatocellular carcinoma (HCC). This analysis included 174 patients with HCC who underwent surgery. Enhanced computed tomography (CT) was performed up to 30 days before surgery. After resection, the size ...
Nishikawa Hiroki - - 2013
The impact of antibodies to hepatitis B core antigen (anti-HBc) on survival after curative surgical resection (SR) for hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) remains unclear. The aim of the present study was to examine the relationship between anti-HBc positivity and survival of HCV-related HCC patients who underwent curative ...
Rae Colin C Radiation Oncology, Institute of Cancer Sciences, Cancer Research United Kingdom Beatson Laboratories, Glasgow, University of Glasgow, Glasgow, United - - 2013
Disulfiram has been used for several decades in the treatment of alcoholism. It now shows promise as an anticancer drug and radiosensitizer. Proposed mechanisms of action include the induction of oxidative stress and inhibition of proteasome activity. Our purpose was to determine the potential of disulfiram to enhance the antitumor ...
Gielen Fabrice - - 2013
The ability to miniaturize biochemical assays in water-in-oil emulsion droplets allows a massive scale-down of reaction volumes, so that high-throughput experimentation can be performed more economically and more efficiently. Generating such droplets in compartment-on-demand (COD) platforms is the basis for rapid, automated screening of chemical and biological libraries with minimal ...
Hwang Ki-Eun - - 2013
The expression levels of Prx1 are frequently elevated in several human cancers, including lung cancer and may confer increased resistance to treatment. In this study, we investigated the role of Prx1 in docetaxel-induced apoptosis in A549 lung cancer cells. To test whether Prx1 knockdown affected the sensitivity of A549 cells ...
Uzarska Marta A - - 2013
The mitochondrial Hsp70 chaperone Ssq1 plays a dedicated role in the maturation of iron-sulfur (Fe/S) proteins, an essential process of mitochondria. Similar to its bacterial orthologue HscA, Ssq1 binds to the scaffold protein Isu1, thereby facilitating dissociation of the newly synthesized Fe/S cluster on Isu1 and its transfer to target ...
Goble Robert - - 2013
The printing press was a game-changing information technology. Risk assessment could be also. At present, risk assessments are commonly used as one-time decision aids: they provide justification for a particular decision, and afterwards usually sit on a shelf. However, when viewed as information technologies, their potential uses are much broader. ...
Sugimoto Yuki - - 2013
SRY-box containing gene 9 (Sox9) and scleraxis (Scx) regulate cartilage and tendon formation, respectively. Here we report that murine Scx(+)/Sox9(+) progenitors differentiate into chondrocytes and tenocytes/ligamentocytes to form the junction between cartilage and tendon/ligament. Sox9 lineage tracing in the Scx(+) domain revealed that Scx(+) progenitors can be subdivided into two ...
Fukuhara Kei - - 2013
An orientational change from homeotropic to planar of liquid crystal (LC) mesogens and the microphase separation (MPS) domains is attained by the segregated skin layer at the free surface. This allows for an efficient in-plane photoalignment of the cylindrical domains. The surface segregation strategy is very simple and is therefore ...
Wang Song - - 2013
Three new pimarane-type diterpenoids, 7β,11α-dihydroxypimara-8(14),15-diene (1), 1β,11α-dihydroxypimara-8(14),15-diene (2), and 11α-hydroxypimara-8(14),15-diene (3), five 2,3-secoaromadendrane-type sesquiterpenoids, including a new one, ethyoxyplagiochiline A2 (4), and three known fusicoccane-type diterpenoids were isolated from the Chinese liverwort Plagiochila pulcherrima. Their structures were established on the basis of extensive spectroscopic analysis. Compounds 6 and 7 exhibited ...
Schulze Kornelius - - 2013
Current imaging technologies do not sufficiently detect micro-metastasis and therefore do not allow adequate stratification of patients with hepatocellular carcinoma (HCC) for curative or systemic therapy. In HCC, presence of stem cell-like, epithelial cell adhesion molecule (EpCAM)-positive cells correlates with tumor aggressiveness and formation of metastasis. Therefore, we investigated the ...
Castilla-Guerra Luis - - 2013
Early prevention of diseases is crucial for public health, especially for stroke and heart disease, the leading causes of morbidity and mortality in the United States. Global geographic disparities in stroke incidence and mortality are substantial. In the United States, residents of the southeastern states endure higher stroke mortality than ...
Corral-Fernández N E - - 2013
MicroRNAs (miRNAs) are involved in gene regulation of several physiological processes. Alterations in the concentrations of miRNAs may result in cancer and autoimmune diseases. In cells of the immune system, miRNA expression is regulated by several cytokines and this expression is related to the inflammatory process. In the present work ...
Benhaiem Sarah S Leibniz Institute for Zoo and Wildlife Research (IZW), Alfred-Kowalke-Strasse 17, Berlin 10315, Germany. - - 2013
Allostatis is the process of maintaining homeostatis through behavioural or physiological responses to challenges, and its cumulative energetic cost is termed allostatic load. The allostatic load hypothesis predicts that hunger and the mechanisms that establish and maintain social dominance should have a strong impact on allostatic load. In spotted hyaenas, ...
Caron Sophie J C SJ Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, New York 10032, - - 2013
The mushroom body in the fruitfly Drosophila melanogaster is an associative brain centre that translates odour representations into learned behavioural responses. Kenyon cells, the intrinsic neurons of the mushroom body, integrate input from olfactory glomeruli to encode odours as sparse distributed patterns of neural activity. We have developed anatomic tracing ...
Dirkes Marcel C - - 2013
Machine perfusion (MP) is a potential method to increase the donor pool for organ transplantation. However, MP systems for liver grafts remain difficult to use because of organ-specific demands. Our aim was to test a novel, portable MP system for hypothermic preservation of the liver. A portable, pressure-regulated, oxygenated MP ...
Hancock Rowena - - 2013
Inhibitors of the Keap1-Nrf2 protein-protein interaction (PPI) have been proposed as potential anti-inflammatory and cancer chemopreventive agents. Such compounds have the potential to increase the intracellular concentrations of Nrf2 in a reversible manner and consequently increase the expression of a battery of gene products with antioxidant response elements (AREs) in ...
Johnson Amber M - - 2013
Bi(iii) ions are capable of reversible, multicomponent self assembly with suitable tris-coordinate ligands. The nature of the self-assembled structures observed are dependent on the ligand coordination geometry, ligand protonation state and Bi concentration. These assemblies can exploit the maximum number of coordination sites at the Bi vertices (nine), and the ...
Merchán Arenas Diego R - - 2013
A new green protocol for the efficient synthesis of pharmacologically relevant 4-amidyl-2-methyl-1,2,3,4-tetrahydroquinolines (THQs) through the domino type ABB' imino Diels-Alder reaction in acidified water in the presence of sodium dodecyl sulphate (SDS) surfactant was developed for the first time. The influence of the SDS micelles and their different concentrations (5.0, ...
Lewis Frank W - - 2013
Two members of the tetradentate N-donor ligand families 6,6'-bis(1,2,4-triazin-3-yl)-2,2'-bipyridine (BTBP) and 2,9-bis(1,2,4-triazin-3-yl)-1,10-phenanthroline (BTPhen) currently being developed for separating actinides from lanthanides have been studied. It has been confirmed that CyMe4-BTPhen 2 has faster complexation kinetics than CyMe4-BTBP 1. The values for the HOMO-LUMO gap of 2 are comparable with those ...
Rubin Daniela A - - 2013
Aim: To compare body composition in children with Prader-Willi syndrome (PWS) not naïve to growth hormone (GH) with obese and lean controls. Methods: Participants included 12 children with PWS, 12 children with obesity (body fat percentage >95th percentile for age and sex) and 12 lean children (body fat percentage <85th ...
Ruiz-Martínez Javier - - 2013
Fluid catalytic cracking (FCC) is the main conversion process used in oil refineries. An X-ray microscopy method is used to show that metal poisoning and related structural changes in the zeolite active material lead to a non-uniform core-shell deactivation of FCC catalyst particles. The study links the detrimental effect of ...
Farrar Mark D - - 2013
BACKGROUND: Vitamin D is essential for bone health, and cutaneous synthesis is an important source. South Asians cannot attain adequate amounts of vitamin D by following general recommendations on summer sunlight exposure at northerly latitudes, and increased exposure may be appropriate for improving their vitamin D status. OBJECTIVE: We examined ...
Kellermann Arthur L - - 2013
At 2:50 p.m. on April 15, nearly 3 hours after the first runner completed the Boston Marathon, two blasts ripped through the crowd that was gathered along the approach to the finish line, killing 3 people and injuring more than 260. Within moments, the crowd's initial panic was replaced by ...
Bohm Matthew - - 2013
Small intestinal bacterial overgrowth (SIBO) can result from failure of the gastric acid barrier, failure of small intestinal motility, anatomic alterations, or impairment of systemic and local immunity. The current accepted criteria for the diagnosis of SIBO is the presence of coliform bacteria isolated from the proximal jejunum with >10(5) ...
Gómez-Robles Aida A Department of Anthropology, The George Washington University, Washington, DC 20052, USA. - - 2013
The study of hominin brain evolution relies mostly on evaluation of the endocranial morphology of fossil skulls. However, only some general features of external brain morphology are evident from endocasts, and many anatomical details can be difficult or impossible to examine. In this study, we use geometric morphometric techniques to ...
Martin Kevan A C - - 2013
Neurons in primary visual cortex of many mammals are clustered according to their preference to stimulus parameters such as orientation and spatial frequency. Nevertheless, responses to complex visual stimuli are highly heterogeneous between adjacent neurons. To investigate the relation between these observations, we recorded from pairs of neighboring neurons in ...
Spoden Gilles G Department of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg University, Mainz, - - 2013
Human papillomavirus type 18 (HPV18), one of the HPVs with malignant potential, enters cells by an unknown endocytic mechanism. The key cellular requirements for HPV18 endocytosis were tested in comparison to those for HPV16 and -31 endocytoses. HPV18 (like HPV16 and -31) entry was independent of clathrin, caveolin, dynamin, and ...
Berg Wendie A WA American College of Radiology Imaging Network, Philadelphia, Pa, USA. - - 2013
To determine prospectively the prevalence and rate of malignancy of multiple bilateral (MB) circumscribed breast masses detected at screening ultrasonography (US) compared with those of other US-depicted masses. This institutional review board-approved, HIPAA-compliant prospective trial included women at elevated risk for breast cancer, who gave written informed consent to participate ...
Rodriguez Erin M EM Department of Psychology and Human Development, Vanderbilt University, Nashville, TN 37203, USA. - - 2013
This study examines associations between maternal depressive symptoms and macro- and micro-level aspects of mothers' communication about their children's cancer. Mothers reported depressive symptoms after diagnosis or relapse (child mean age = 10.4 years; 53% male). Mother-child dyads (N = 94) were subsequently observed discussing the child's cancer and maternal ...
Moulouel Boualem - - 2013
Hepcidin, the key regulatory hormone of iron homeostasis, and iron carriers such as transferrin receptor1 (TFR1), divalent metal transporter1 (DMT1), and ferroportin (FPN) are expressed in kidney. Whether hepcidin plays an intrinsic role in the regulation of renal iron transport is unknown. Here, we analyzed the renal handling of iron ...
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