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Zeidan Fadel - - 2013
Anxiety is the cognitive state related to the inability to control emotional responses to perceived threats. Anxiety is inversely related to brain activity associated with the cognitive regulation of emotions. Mindfulness meditation has been found to regulate anxiety. However, the brain mechanisms involved in meditation-related anxiety relief are largely unknown. ...
Wang Fang - - 2013
Six new glycosides (1-6) have been isolated from the flower buds of Lonicera japonica. Their structures including the absolute configurations were determined by spectroscopic and chemical methods as ( - )-2-hydroxy-5-methoxybenzoic acid 2-O-β-d-(6-O-benzoyl)-glucopyranoside (1), ( - )-4-hydroxy-3,5-dimethoxybenzoic acid 4-O-β-d-(6-O-benzoyl)-glucopyranoside (2), ( - )-(E)-3,5-dimethoxyphenylpropenoic acid 4-O-β-d-(6-O-benzoyl)-glucopyranoside (3), ( - )-(7S,8R)-(4-hydroxyphenylglycerol 9-O-β-d-[6-O-(E)-4-hydroxy-3,5-dimethoxyphenylpropenoyl]-glucopyranoside (4), ( - )-(7S,8R)-(4-hydroxy-3-methoxyphenylglycerol 9-O-β-d-[6-O-(E)-4-hydroxy-3,5-dimethoxyphenylpropenoyl]-glucopyranoside (5), and ( - )-4-hydroxy-3-methoxyphenol β-d-{6-O-[4-O-(7S,8R)-(4-hydroxy-3-methoxyphenylglycerol-8-yl)-3-methoxybenzoyl]}-glucopyranoside (6), ...
Gower Barbara A BA Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294-3360, USA. - - 2013
Animal studies indicate that osteocalcin (OC), particularly the undercarboxylated isoform (unOC), affects insulin sensitivity and secretion, but definitive data from humans are lacking. The objectives of the study were to determine whether total OC and unOC are independently associated with insulin sensitivity and β-cell response in overweight/obese adults; whether glucose ...
Grandisson Marie - - 2013
Abstract Purpose: Community-based rehabilitation (CBR) must prove that it is making a significant difference for people with disabilities in low- and middle-income countries. Yet, evaluation is not a common practice and the evidence for its effectiveness is fragmented and largely insufficient. The objective of this article was to review the ...
Ruljancic Nedjeljka - - 2013
The pathophysiology and treatment of depression involves monoamine neurotransmitters and the magnesium (Mg)-modulated monoaminergic pathway. Serum and platelet Mg concentrations and platelet serotonin concentrations were measured in 79 depressed patients who had attempted suicide, and 101 patients without suicidal behaviour, according to the ICD-10 diagnoses F 33.2 and F32.2, with ...
Tubon Thomas C TC - - 2013
CREB-responsive transcription has an important role in adaptive responses in all cells and tissue. In the nervous system, it has an essential and well established role in long-term memory formation throughout a diverse set of organisms. Activation of this transcription factor correlates with long-term memory formation and disruption of its ...
Mounce Bryan C BC Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin, - - 2013
Gammaherpesviruses are ubiquitious pathogens that establish lifelong infection and are associated with several malignancies. All gammaherpesviruses encode a conserved protein kinase that facilitates viral replication and chronic infection and thus represents an attractive therapeutic target. In this study, we identify a novel function of gammaherpesvirus protein kinase as a regulator ...
Roldán Elena Moreno - - 2013
Abstract Viruses are the leading cause of foodborne illness associated with the consumption of raw or slightly cooked contaminated shellfish. The aim of this study was to evaluate the prevalence of hepatitis A virus in molluscs. Standard and real-time reverse transcription-polymerase chain reaction procedures were used to monitor bivalve molluscs ...
Walsh Michael M Department of Medicine-Nephrology, St Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada. - - 2013
Patients with antineutrophil cytoplasm antibody-associated vasculitis (AAV) requiring dialysis at diagnosis are at risk for developing end-stage renal disease (ESRD) or dying. Short-term results of a trial comparing plasma exchange (PLEX) to intravenous methylprednisolone (IV MeP) suggested PLEX improved renal recovery. Here we conducted long-term follow-up to see if this ...
Wang Mei - - 2013
Colonization of the intestinal microbiota after birth plays an important role in development of the neonatal gastrointestinal and immune systems. Two key environmental factors that influence the colonization pattern are delivery mode and nutrition. In this study, the impact of delivery mode and nutrition on microbial colonization and metabolic activity ...
Pastor José M JM Departamento de Bioquímica y Biología Molecular B e Inmunología. Facultad de Química, Campus Regional de Excelencia Internacional "Campus Mare Nostrum," Universidad de Murcia, 30100 Murcia, - - 2013
Bacterial osmoadaptation involves the cytoplasmic accumulation of compatible solutes to counteract extracellular osmolarity. The halophilic and highly halotolerant bacterium Chromohalobacter salexigens is able to grow up to 3 m NaCl in a minimal medium due to the de novo synthesis of ectoines. This is an osmoregulated pathway that burdens central ...
Perez Carlos J CJ e Department of Molecular Carcinogenesis, The University of Texas M. D. Anderson Cancer Center, Smithville, TX, - - 2013
G protein-coupled receptor 84 (GPR84) is a 7-transmembrane protein expressed on myeloid cells that can bind to medium-chain free fatty acids in vitro. Here, we report the discovery of a 2-bp frameshift deletion in the second exon of the Gpr84 gene in several classical mouse inbred strains. This deletion generates ...
Vidovic Sinisa S Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, - - 2013
A population-based study combining (i) antimicrobial, (ii) genetic, and (iii) virulence analyses with molecular evolutionary analyses revealed segregative characteristics distinguishing human clinical and bovine Escherichia coli O157 strains from western Canada. Human (n = 50) and bovine (n = 50) strains of E. coli O157 were collected from Saskatchewan and ...
Migraine Audrey - - 2013
BACKGROUND: Preterm infants frequently present eating difficulties in early childhood. Determinants of these difficulties are not known. OBJECTIVE: We assessed the influence of neonatal and maternal characteristics on eating behaviors at 2 y of age. DESIGN: The following 2 cohorts were compared: 234 preterm children born <33 wk of gestational ...
Bliuc Dana - - 2013
CONTEXT: Following fracture there is increased risk of re-fracture and premature mortality. These outcomes, particularly premature mortality following re-fracture, have not previously been studied together to understand overall mortality risk. OBJECTIVES: This study examined the long-term cumulative incidence of subsequent fracture and total mortality with mortality calculated as a compound ...
Worasith Niramon - - 2013
Electron paramagnetic resonance (EPR) investigations of hair samples from various male and female subjects of different ages and races have revealed considerable variability in their Cu(II) signals. These signals seem to be a combination of two components whose relative proportions differ widely, although both have the relationship g// > g⊥ ...
Raz Gal - - 2013
Two empathy-related processes were recently distinguished neuroscientifically: automatic embodied-simulation (ES) based on visceromotor representation of another's affective state via cingulo-insulary circuit, and emotional sharing relying on cognitive "theory of mind" (ToM) via prefrontal-temporo-parietal circuit. Evidence that these regions are not only activated but also function as networks during empathic experience ...
Kullmann Lars - - 2013
For prey capture in the dark, the barn owl Tyto alba has evolved into an auditory specialist with an exquisite capability of sound localization. Adaptations include asymmetrical ears, enlarged auditory processing centers, the utilization of minute interaural time differences, and phase locking along the entire hearing range up to 10 ...
Rantalainen Timo - - 2013
Context:Increased mechanical loading can promote the preferential differentiation of bone marrow mesenchymal stem cells to osteoblastogenesis, but it is not known whether long-term bone strength-enhancing exercise in humans can reduce marrow adiposity.Objective:Our objective was to examine whether bone marrow density (MaD), as an estimate of marrow adiposity 1) differs between ...
Pringle Jan - - 2013
Abstract Purpose: This study aimed to investigate and improve understanding of the experiences of patients and their carers during the first month at home following discharge from hospital, thereby enhancing appropriate care from a more informed perspective. Method: In-depth interviews and self-report diaries were used to capture data from 12 ...
Cornall Alyssa M - - 2013
Anal squamous cell carcinomas are predominantly associated with high-risk human papillomaviruses (HPV), particularly HPV 16, similar to cervical, vaginal and vulvar cancers. Although the presence of "low-risk" HPVs, in particular genotypes 6 and 11, have occasionally been reported in various HPV-related anogenital cancers, the overall distribution of these genotypes in ...
Gardner Ryan T - - 2013
Sympathetic nerves can regenerate after injury to reinnervate target tissues. Sympathetic regeneration is well documented after chronic cardiac ischemia, so we were surprised that the cardiac infarct remained denervated following ischemia-reperfusion (I-R). We used mice to ask if the lack of sympathetic regeneration into the scar was due to blockade ...
Chen Chen - - 2013
Abstract Context: Cilnidipine (CN) is a novel dihydropyridine calcium antagonist that is practically insoluble in aqueous media and exhibits a low oral bioavailability or limited clinical efficacy. Objective: This study investigated the effects of three commercial and chemically diverse polymers - PVP, PVP/VA and Soluplus - on crystallization tendency and ...
Ishino Tetsuya T Global Biotherapeutics Technologies, Pfizer Inc., Cambridge, Massachusetts 02140, USA. - - 2013
Human IgG is a bivalent molecule that has two identical Fab domains connected by a dimeric Fc domain. For therapeutic purposes, however, the bivalency of IgG and Fc fusion proteins could cause undesired properties. We therefore engineered the conversion of the natural dimeric Fc domain to a highly soluble monomer ...
Sokolova Inna M - - 2013
Integrating the effects of multiple stressors and predicting their consequences for the species' survival and distribution is an important problem in ecological physiology. This review applies the concept of energy-limited tolerance to stress to develop bioenergetic markers that can assist in integrating the effects of multiple stressors and distinguishing between ...
Liu Yang - - 2013
10-23 DNAzyme has been used as a very good model for exploring the potential of functional nucleic acids. Its 15-mer catalytic core has been demonstrated to be the optimized in vitro selection result. However, with the introduction of protein-like functional groups through 2'-deoxyguanosine analogues, its two highly conserved guanine residues ...
Ozsutcu Mustafa - - 2013
Objective: The purpose of this study was to investigate autonomic nervous system dysfunction by measuring pupil sizes in pediatric patients with allergic rhinitis. Subjects and Methods: The study group consisted of 60 children (28 girls and 32 boys) who were age and gender matched with the control group, which also ...
Bertoia Monica L ML Brown University, Providence, RI, USA. - - 2013
Alcohol and caffeine intakes may play a role in the development of sudden cardiac death (SCD) because of their effects on cholesterol, blood pressure, heart rate variability, and inflammation. Our objective was to examine the association between long-term alcohol and caffeine intakes and risk of SCD in women. We examined ...
Naoda Koji - - 2013
Au revoIR: Hexaphyrin Au(III) -Ir(III) complexes were prepared from the reaction of a mono-Au(III) [26]hexaphyrin complex with [IrCl(cod)]2 followed by treatment with pyridine. N-Fusion reaction of this complex gave a syn-doubly N-fused hexaphyrin as the major product, which displayed antiaromatic properties such as strong paratropic ring current, a small HOMO-LUMO ...
Plundrich Nathalie - - 2013
Botanical agents that are antimicrobial, or that modulate skin hyperpigmentation via tyrosinase inhibition, are increasingly sought in the cosmetic industry. In this study, an efficient tactic is demonstrated for concentrating and stabilizing skin-beneficial bioactive compounds from muscadine grape and blackcurrant juice and pomace sources into hemp flour (HF), hemp protein ...
Tietze Lutz F - - 2013
An open question: Activity-based protein profiling using seco-CBI derivative 1, containing a DNA-binding indole unit, showed that besides binding to DNA, compound 1 also interacts with aldehyde dehydrogenase 1. However, for CBI compounds without an indole unit, the origin of their cytotoxicity has not been identified, yet.
Vanoosthuyze K - - 2013
Today, a majority of the general population describe themselves as having sensitive skin. Although this is often considered more of a problem for women, the number of men claiming this condition is substantial. The objective of these studies was to evaluate dermatologists' perceptions with regard to the prevalence of sensitive ...
Coutts Shelagh B - - 2013
The use of MRI to evaluate patients with TIA has increased dramatically over the last 10 years. Most studies have found a higher risk of recurrent stroke when there is evidence of restricted diffusion on brain MRI. However, much of the published work has been from relatively small single-center studies ...
Hussaini Syed Abid - - 2013
Free-flying honeybees (Apis mellifera carnica) are known to learn the context to solve discrimination tasks. Here we apply classical conditioning of the proboscis extension response in restrained bees in combination with single-unit extracellular recordings from mushroom body (MB) extrinsic neurons elucidating the neural correlates of context-dependent olfactory discrimination. The contexts ...
Xiong Xiaoli X MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, - - 2013
Cell-surface-receptor binding by influenza viruses is a key determinant of their transmissibility, both from avian and animal species to humans as well as from human to human. Highly pathogenic avian H5N1 viruses that are a threat to public health have been observed to acquire affinity for human receptors, and transmissible-mutant-selection ...
Turk Gabriela G Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina. - - 2013
The important role of the CD8(+) T-cell response on HIV control is well established. Moreover, the acute phase of infection represents a proper scenario to delineate the antiviral cellular functions that best correlate with control. Here, multiple functional aspects (specificity, ex vivo viral inhibitory activity [VIA] and polyfunctionality) of the ...
Tominaga Takashi - - 2013
Recent advances in fluorescent confocal microscopy and voltage-sensitive and Ca(2+) dyes have vastly improved our ability to image neuronal circuits. However, existing confocal systems are not fast enough, or too noisy, for many live-cell functional imaging studies. Here we describe, and demonstrate the function of a novel, non-scanning confocal microscopy ...
Sudagidan Mert - - 2013
Abstract The resistance of foodborne Staphylococcus aureus isolates to antimicrobial agents is an increasing problem. In this study, 154 S. aureus food isolates were examined on the basis of inducible clindamycin resistance and the presence of ermABC genes. Furthermore, the genetic relatedness of S. aureus strains having inducible and constitutive ...
Griesbeck Axel G - - 2013
The singlet oxygen reactions of 4-methyl-2,4-hexadienoates E,E- and E,Z-4 proceed in a highly mode selective and regioselective domino process. The initial product is the allylic hydroperoxide 5 directed by a vinylogous gem effect. The subsequent (1)O2 [4 + 2] cycloaddition delivers a 3:2 diastereoisomeric mixture of 1,2-dioxanes 8 in a ...
Schoeller Dale A - - 2013
Light element isotope signatures have been used to study food webs in many ecological niches, including those of ancient humans, but to a far lesser extent in modern humans. A recent paper presented results from a pilot study testing the utility of carbon isotope ratio analysis of alanine to measure ...
Chao Che-Yi - - 2013
Matrix metalloproteinase-9 (MMP-9) plays a critical role in cancer metastasis. Andrographolide (AP) is a diterpene lactone in the leaves and stem of Andrographis paniculata (Burm. f) Ness that has been reported to possess anti-cancer activity. In this study, we investigated the effect of AP on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and ...
Jin Min-Yi - - 2013
Yeputaoteng is the dried ground part of Ampelopsis sinica (Miq.) W.T. Wang, which is widely used in traditional Chinese medicine for preventing and treating tumors, chronic nephritis, hepatitis, rubella, traumatic bleeding, stomach heat and vomiting. A simple and reliable method using high-performance liquid chromatography with diode array detection (HPLC-DAD) was ...
Palaniyappan Lena - - 2013
The point of rarity in brain structure and function that separates the 2 major psychotic disorders-schizophrenia and bipolar disorder-is presently unknown. The aim of this study is to combine surface anatomical and functional imaging modalities to quantify the integrity of cortical connectivity in pursuit of the neural basis of the ...
Bryant Jonathan J - - 2013
The copper-catalyzed azide-alkyne "click" cycloaddition reaction is an efficient coupling reaction that results in the formation of a triazole ring. The wide range of applicable substrates for this reaction allows the construction of a variety of conjugated systems. The additional function of triazoles as metal-ion ligands has led to the ...
Zhu Hao H Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, - - 2013
A facile one-pot synthesis of highly water-dispersible size-tunable magnetite (Fe3O4) nanocrystal clusters (MNCs) end-functionalized with amino or carboxyl groups by a modified solvothermal reduction reaction has been developed. Dopamine and 3,4-dihydroxyhydroxycinnamic acid were used for the first time as both a surfactant and interparticle linker in a polylol process for ...
Mourani Peter M - - 2013
PURPOSE OF REVIEW: Pulmonary hypertension contributes significantly to morbidity and mortality of chronic lung disease of infancy, or bronchopulmonary dysplasia (BPD). Advances in pulmonary vascular biology over the past few decades have led to new insights into the pathogenesis of BPD; however, many unique issues persist regarding our understanding of ...
Cai Hui - - 2013
The T-helper epitope peptide P30 (green in the scheme) from tetanus toxoid was used as the immunostimulant in MUC1 glycopeptide antitumor vaccines and apparently also acts as a built-in adjuvant. P30-conjugated glycopeptide vaccines containing three glycans in the immunodominant motifs PDTRP and GSTAP induced much stronger immune responses and complement ...
Agnelli Luca L University of Milan, Department of Clinical Sciences and Community Health, F. Sforza, 35 - 20122 Milan, - - 2013
Multiple myeloma is a fatal malignant proliferation of clonal bone marrow Ig-secreting plasma cells, characterized by wide clinical, biological, and molecular heterogeneity. Herein, global gene and microRNA expression, genome-wide DNA profilings, and next-generation sequencing technology used to investigate the genomic alterations underlying the bio-clinical heterogeneity in multiple myeloma are discussed. ...
Bevilacqua Francesca - - 2013
Objective To describe short-term neurodevelopmental outcome of infants operated on for congenital anomalies (CA) and assess the impact of type of CA on the outcome.Study Design From 2008 to 2010 newborns operated on for CA were enrolled in a cross-sectional follow-up study including three distinct groups: infants of 6 months ...
Ghosh Supriya - - 2013
The cellular and molecular effects of stress on the amygdala are strikingly different compared with those in the hippocampus. Previous findings on stress-induced plasticity were based primarily on postmortem analysis within individual areas. However, little is known about how stress affects dynamic changes and interactions in neuronal activity between the ...
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