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Kim Je Sang - - 2013
Background: We frequently encounter high levels of activated partial thromboplastin time (aPTT) during heparin anticoagulation. The purpose of this study is, first, to investigate the rate of achieving and maintaining therapeutic aPTT in patients treated with heparin anticoagulation and second, to assess the adequacy the current nomogram. Methods: We included ...
Oshikawa Mio - - 2013
Cell cycle dysregulation leads to abnormal proliferation and cell death in a context-specific manner. Cell cycle progression driven via the Rb pathway forces neurons to undergo S-phase, resulting in cell death associated with the progression of neuronal degeneration. Nevertheless, some Rb- and Rb family (Rb, p107 and p130)-deficient differentiating neurons ...
Licko Thomas - - 2013
PURPOSE: The antiepileptic drug, lacosamide, exerts its therapeutic activity by enhancing slow inactivation of voltage-gated sodium channels. Because putative preventive or disease-modifying effects of drugs may affect epileptogenesis, intrinsic severity, and comorbidities, it is of particular interest to assess the effect of lacosamide on the development of epilepsy and associated ...
Di Bonito Procolo - - 2013
Objective: To evaluate the relationship between estimated glomerular filtration rate (eGFR) and cardiometabolic risk factors (CMRF) in an outpatient pediatric population with high prevalence of obesity. Design and Methods: eGFR was evaluated in 901 children unselected for chronic kidney disease (CKD) of whom 694 were overweight/obese (6-16 years) and 207 ...
Dorsey E Ray ER Department of Neurology, Johns Hopkins Medicine, Baltimore, MD, USA. - - 2013
As the U.S. population ages, the burden of neurodegenerative disorders, including Alzheimer disease and Parkinson disease, will increase substantially. However, many of these patients and their families currently do not receive neurologic care. For example, a recent study found that over 40% of Medicare beneficiaries with an incident Parkinson disease ...
Szczeszak Agata - - 2013
Triclinic Gd1-xEuxBO3 nanophosphors have been prepared by a hydrothermal method without using additional coreagents and prior precipitation of precursor (in situ). The formation of the borate nanorods and their crystal structure was refined on the basis of X-ray diffraction patterns (XRD) and well confirmed using various techniques such as infrared ...
Maharaj Yushir - - 2013
Using an integrated computational approach involving homology modeling, Pharmacophore/Structure-Based virtual screening, molecular dynamics simulations and per-residue energy contribution, ten compounds were proposed as potential TB inhibitors. Via validated docking calculations, binding free energy calculations showed that the proposed compounds presented better binding affinity with DNA Gyrase B when compared to ...
Subramanian Jaichandar - - 2013
The small GTPase Rap1 contributes to fear learning and cortico-amygdala plasticity by inhibiting glutamate release from cortical neurons, but mechanisms of this inhibition remain unknown. Conversely, L-type calcium channels (LTCCs) become involved in glutamate release after fear learning and LTP induction. Here, we show that Rap1 deletion in mouse primary ...
Benner Eric J EJ George and Jean Brumley Neonatal-Perinatal Research Institute, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina 27710, - - 2013
Postnatal/adult neural stem cells (NSCs) within the rodent subventricular zone (SVZ; also called subependymal zone) generate doublecortin (Dcx)(+) neuroblasts that migrate and integrate into olfactory bulb circuitry. Continuous production of neuroblasts is controlled by the SVZ microenvironmental niche. It is generally thought that enhancing the neurogenic activities of endogenous NSCs ...
Spannaus Ralf R Universität Würzburg, Institut für Virologie und Immunbiologie, Würzburg, - - 2013
In contrast to orthoretroviruses, processing of foamy viral p71 Gag is limited to a single cleavage site. Nevertheless, Gag maturation is essential for infectivity, but deletion of p3 results in a modest drop in infectivity. Here, we show that Gag processing of p71 to p68 and p3 is essential for ...
Li Fei F Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut, - - 2013
Murine leukemia virus (MLV) can efficiently spread in tissue cultures by polarizing assembly to virological synapses. The viral envelope glycoprotein (Env) establishes cell-cell contacts and subsequently recruits Gag by a process that depends on its cytoplasmic tail. MLV Gag is recruited to virological synapses through the matrix domain (MA) (J. ...
Zhang Qunzhou - - 2013
PURPOSE: Osteonecrosis of the jaw (ONJ) is emerging as one of the important complications in cancer patients treated with antiresorptive agents. This study explored the potential role of IL-17-mediated M1/M2 macrophage alterations in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ). EXPERIMENTAL DESIGN: The expression of IL-17 and M1 ...
Federman Noel - - 2013
Memory consolidation requires gene expression regulation by transcription factors, which eventually may induce chromatin modifications as histone acetylation. This mechanism is regulated by histone acetylases and deacetylases. It is not yet clear whether memory consolidation always recruits histone acetylation or it is only engaged in more persistent memories. To address ...
He Chunnian - - 2013
A facile and scalable in-situ synthesis strategy is developed to fabricate carbon encapsulated Fe3O4 nanoparticles homogeneously embedded in two-dimensional (2D) porous graphitic carbon nanosheets (Fe3O4@C@PGC nanosheets) as a durable high-rate lithium ion battery anode material. With assistance of the surface of NaCl particles, 2D Fe@C@PGC nanosheets can be in-situ synthesized ...
Lococo Filippo F Department of Thoracic Surgery, Catholic University, Rome, Italy. - - 2013
The efficacy of endoscopic ultrasound (EUS) for evaluating mediastinal adenopathy in lung cancer is nowadays proven. However, its accuracy for detection of malignant pleural effusion per se has not been yet investigated. Herein we report our experience with EUS for detecting pleural effusion during the staging procedure of non-small cell ...
Demondion Pierre - - 2013
OBJECTIVES: The twin aims of this study were to identify the independent predictors of 30-day mortality and to analyse the outcomes of patients with cardiogenic shock (CS) associated with acute myocardial infarction (AMI) and necessitating extracorporeal life support (ECLS). METHODS: The investigation was a single-centre, retrospective study of 77 patients ...
Liu Guixia - - 2013
Give it a tweak: A novel oxidizing directing group was developed for a rhodium(III)-catalyzed CH functionalization of N-phenoxyacetamides with alkynes. A small change in the reaction conditions leads to either ortho-hydroxyphenyl-substituted enamides or cyclization to deliver benzofurans with high selectivity (see scheme; Cp*=C5 Me5 ).
Cheah C Y - - 2013
BackgroundCentral nervous system (CNS) involvement in mantle cell lymphoma (MCL) is uncommon, and the manifestations and natural history are not well described.Patients and methodsWe present the data on 57 patients with MCL who developed CNS involvement, from a database of 1396 consecutively treated patients at 14 institutions.ResultsThe crude incidence of ...
Lawson Marie - - 2013
The synthesis of 2-α-styrylpyridines has been carried out by using the coupling of polyoxygenated N-tosylhydrazones with various 2-halopyridines. We demonstrated that the use of a catalytic amount of PdCl2(MeCN)2 in combination with a bidentate ferrocene DPPF or a monodentate alkyl phosphine (t)Bu2MeP-HBF4 constitutes an efficient protocol for this coupling, providing ...
Xiang Zhao-Bao - - 2013
A new ent-kaurane diterpenoid glycoside (1), named glaucocalyxin G, has been isolated from the n-butanol-soluble fraction of the dried whole plants of Isodon japonica var. glaucocalyx along with two known compounds, namely arjunglucoside (2) and kaempferol-3-O-rutinoside (3). The structures of the isolated compounds were assigned on the basis of their ...
Rechel B - - 2013
The aim of this study was to ascertain the levels and mechanisms of funding public health in Europe.A review of published and unpublished documents and expenditure data was undertaken.Expenditure on public health in Europe is difficult to determine, but data from national health accounts suggest that it differs greatly across ...
Corriveau Mark M Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, - - 2013
Telomeres are macromolecular nucleoprotein complexes that protect the ends of eukaryotic chromosomes from degradation, end-to-end fusion events, and from engaging the DNA damage response. However, the assembly of this essential DNA-protein complex is poorly understood. Telomere DNA consists of the repeated double-stranded sequence 5'-TTAGGG-3' in vertebrates, followed by a single-stranded ...
Bauminger-Zviely Nirit - - 2013
This study examined the effectiveness of a school-based, collaborative technology intervention combined with cognitive behavioral therapy to teach the concepts of social collaboration and social conversation to children with high-functioning autism spectrum disorders (n = 22) as well as to enhance their actual social engagement behaviors (collaboration and social conversation) ...
Greenberg Russell R Smithsonian Migratory Bird Center, Smithsonian Conservation Biology Institute, National Zoological Park, Washington, DC 20008, USA. - - 2013
Sexual size dimorphism is expected to be more pronounced in vertebrates on islands, particularly in trophic characters, as a response to decreased interspecific competition for food. We found (based on measurements of 1423 museum specimens) that bill size dimorphism was greater in island than mainland populations of song sparrows. However, ...
Bernien H - - 2013
Quantum entanglement between spatially separated objects is one of the most intriguing phenomena in physics. The outcomes of independent measurements on entangled objects show correlations that cannot be explained by classical physics. As well as being of fundamental interest, entanglement is a unique resource for quantum information processing and communication. ...
Lu Yanping - - 2013
The solution behaviors and microstructures of poly(N-isopropylacrylamide)x-poly(ethylene oxide)20-poly(propylene oxide)70-poly(ethylene oxide)20-poly(N-isopropylacrylamide)x (PNIPAmx-PEO20-PPO70-PEO20-PNIPAmx or PNIPAmx-P123-PNIPAmx) pentablock terpolymers with various PNIPAm block lengths in dilute and concentrated aqueous solutions were investigated by micro-differential scanning calorimetry (micro-DSC), static and dynamic light scattering (SLS & DLS), and synchrotron small angle X-ray scattering (SAXS). Two lower ...
Matoba Keiichiro - - 2013
The small GTPase Rho and its effector Rho-kinase are involved in the pathogenesis of diabetic nephropathy. Accumulating evidence shows that hypoxia-inducible factor-1α (HIF-1α) is a key regulator of renal sclerosis under diabetic conditions. However, the interactions of Rho-kinase and HIF-1α in the development of renal dysfunction have not been defined. ...
Kwon Deborah Y DY Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, - - 2013
Spinal muscular atrophy is an inherited motor neuron disease that results from a deficiency of the survival of motor neuron (SMN) protein. SMN is ubiquitinated and degraded through the ubiquitin proteasome system (UPS). We have previously shown that proteasome inhibition increases SMN protein levels, improves motor function, and reduces spinal ...
Xu Jinxin J State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, - - 2013
Sorting nexins are phox homology (PX) domain-containing proteins involved in diverse intracellular endosomal trafficking pathways. The PX domain binds to certain phosphatidylinositols and is recruited to vesicles rich in these lipids. The structure of the PX domain is highly conserved, containing a three-stranded β-sheet, followed by three α-helices. Here, we ...
Ordomsky Vitaly V - - 2013
A solid acid foam-structured catalyst based on a binderless zirconium phosphate (ZrPO) coating on aluminum foam was prepared. The catalyst layer was obtained by performing a multiple washcoating procedure of ZrPO slurry on the anodized aluminum foam. The effect of the pretreatment of ZrPO, the concentration of the slurry, and ...
Mosconi Tony T Department of Physical Therapy, Western University of Health Sciences, Pomona, CA, - - 2013
Trigeminal ganglion (TG) neurons innervate the grid-like array of whisker follicles on the face of the mouse. Central TG axons project to the trigeminal (V) brainstem nuclear complex, including the nucleus principalis (PrV) and the spinal subnucleus interpolaris (SpVi), where they innervate barrelettes that are organized in a pattern that ...
van der Poel-van de Luytgaarde Sonja C P A M - - 2013
The isolation of high-quality RNA and DNA from various specimens is essential to perform reliable molecular diagnostic assays. In routine diagnostics of hematologic malignancies isolation of high-quality RNA is a prerequisite. We used QIAsymphony technology (QST) using a customized RNA CT 800 V6 protocol for automated semi-high-throughput isolation of RNA ...
Liu Xinghui - - 2013
We present a unique experimental configuration that allows us to determine the interfacial forces on nearly parallel plates made from the thinnest possible mechanical structures, single and few layer graphene membranes. Our approach consists of using a pressure difference across a graphene membrane to bring the membrane to within ~ ...
Dong Hai-Ling - - 2013
Five new glucosides, shancigusins E-I (1-5) were isolated from the tubers of Pleione yunnanensis (Rolfe) together with 18 known compounds. The structures of these compounds were determined by extensive analyses of their spectroscopic data. Copyright © 2013 John Wiley & Sons, Ltd.
Winston Gavin P - - 2013
Temporal lobe epilepsy (TLE) has been considered to impair long-term memory, whilst not affecting working memory, but recent evidence suggests that working memory is compromised. Functional MRI (fMRI) studies demonstrate that working memory involves a bilateral frontoparietal network the activation of which is disrupted in hippocampal sclerosis (HS). A specific ...
Winther Christina S - - 2013
The adrenocortical human cell line H295R is a valuable tool for screening endocrine disrupting compounds. In general, previous research focus has been on the production of the 2 sex steroids, 17β-estradiol and testosterone, and less attention has been paid to other important steroid end points in the steroidogenesis with a ...
Brunton Laura K - - 2013
Abstract Purpose: The aim of the study was to describe the lived bodily experience of cerebral palsy (CP). Method: This was a descriptive phenomenological inquiry. Ten participants were interviewed about their bodily experiences of living with CP. Interviews were semi-structured around pain and fatigue. Inductive thematic analysis was used to ...
Eiselt Anne-Kathrin - - 2013
Processing quantity information based on abstract principles is central to intelligent behavior. Neural correlates of quantitative rule selectivity have been identified previously in the prefrontal cortex (PFC). However, whether individual neurons represent rules applied to multiple magnitude types is unknown. We recorded from PFC neurons while monkeys switched between "greater ...
Huang Yang - - 2013
Bending manipulation and direct force measurements of ultrathin boron nitride nanotubes (BNNTs) were performed inside a transmission electron microscope. Our results demonstrate an obvious transition in mechanics of BNNTs when the external diameters of nanotubes are in the range of 10 nm or less. During in situ transmission electron microscopy ...
Luykx Jurjen J JJ Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht (UMCU), Utrecht, the - - 2013
The glutamatergic neurotransmission system and the N-methyl-D-aspartate receptor (NMDAR) have been implicated in smoking and alcohol consumption behavior. Preclinical studies have demonstrated that nicotine and ethanol influence NMDAR functionality, which may have a role in tendencies to consume these substances. Nonetheless, little is known about concentrations of NMDAR coagonists in ...
Ozbay Ismail - - 2013
Baling technology is a preferred method for temporary storage of municipal solid waste (MSW) prior to final disposal. If incineration is intended for final disposal of the bales, the energy content of the baled MSW gains importance. In this study, nine cylindrical bales containing a mix of different waste materials ...
Mallamaci Francesca - - 2013
Long-term visit-to-visit blood pressure (BP) variability predicts a high risk for cardiovascular events in patients with essential hypertension. Whether long-term visit-to-visit BP variability holds the same predictive power in predialysis patients with chronic kidney disease (CKD) is unknown. Here we tested the relationship between long-term visit-to-visit office BP variability and ...
Sun Jie - - 2013
Vasohibin-2 was recently identified as an important pro-angiogenesis factor in solid tumor and intracellular localization of its variants is important for elucidating the downstream mechanism(s) of its effects. Currently there are no reported antibodies affordable for intracellular localization. The aim of this study was to generate and characterize polyclonal antibodies ...
Maurage Pierre - - 2013
A correlation observed between chocolate consumption and the number of Nobel laureates has recently led to the suggestion that consuming more chocolate would increase the number of laureates due to the beneficial effects of cocoa-flavanols on cognitive functioning. We demonstrate that this interpretation is disproved when other flavanol-rich nutriment consumption ...
Arvizo Rochelle R RR Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, - - 2013
Nanoparticles provide a potent tool for targeting and understanding disease mechanisms. In this regard, cancer cells are surprisingly resistant to the expected toxic effects of positively charged gold nanoparticles ((+)AuNPs). Our investigations led to the identification of MICU1, regulator of mitochondrial calcium uniporter, as a key molecule conferring cancer cells ...
Turner Claire E CE Infectious Diseases & Immunity, Imperial College London, Hammersmith Hospital, London, United - - 2013
Sepsis is now the leading direct cause of maternal death in the United Kingdom, and Streptococcus pyogenes is the leading pathogen. We combined conventional and genomic analyses to define the duration and scale of a lethal outbreak. Two postpartum deaths caused by S. pyogenes occurred within 24 h; one was ...
Sachs Michael C MC Kidney Research Institute and Division of Nephrology, University of Washington, Seattle, WA, USA. - - 2013
The seasonal variation in circulating 25-hydroxyvitamin D [25(OH)D] concentrations is large relative to mean values. Single measurements may misclassify annual exposure, which may lead to bias in research and complicate clinical decision making. We aimed to develop and validate a model for adjusting a single measurement of a serum 25(OH)D ...
Romano Joseph - - 2013
Thirty years after its beginning, the HIV/AIDS epidemic is still raging around the world. According to UNAIDS, in 2011 alone 1.7M deaths were attributable to AIDS, and 2.5M people were newly infected by the virus. Despite the success in treating HIV-infected people with potent antiretroviral drugs, preventing HIV infection is ...
Kim Hyungki - - 2013
Direct growth of a single to a few layers of graphene on a germanium nanowire (Gr/Ge NW; see picture) was achieved by a metal-catalyst-free chemical vapor deposition (CVD) process. The Gr/Ge NW was used as anode in a lithium ion battery. This material has a specific capacity of 1059 mA h g(-1) ...
Quinto Francesca - - 2013
(236)U was analyzed in a minerotrophic peat from the last interglacial period and an ombrotrophic peat core representing the last 80 years of atmospheric deposition. The determination of (236)U at levels of 10(7) atoms/g was possible by using ultra-clean laboratory procedures and accelerator mass spectrometry. In the interglacial peat samples ...
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