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Zhang Jing - - 2013
Polyoxometalate (POM) complex (DODA)2 [Mo6 O19 ] with a symmetrical linear structure was prepared conveniently by replacing the tetrabutylammonium (TBA) counterions of Lindquist-type cluster (TBA)2 [Mo6 O19 ] with cationic surfactant dioctadecyldimethylammonium (DODA). A helical self-assembled structure of the complex was formed in dichloromethane/propanol. The dynamically reversible transformation between helical ...
Sadlish Heather - - 2013
Translation initiation is an emerging target in oncology and neurobiology indications. Naturally derived and synthetic rocaglamide scaffolds have been used to interrogate this pathway, however, there is uncertainty regarding their precise mechanism(s) of action. We exploited the genetic tractability of yeast to define the primary effect of both a natural ...
Tenzer Stefan - - 2013
RALY is a member of the heterogeneous nuclear ribonucleoproteins, a family of RNA-binding proteins generally involved in many processes of mRNA metabolism. No quantitative proteomic analysis of RALY-containing ribonucleoparticles (RNPs) has been performed so far and the biological role of RALY remains elusive. Here, we present a workflow for the ...
Müller Michael - - 2013
The controversy over the absolute configuration of (+)-erythro-mefloquine, the less psychosis-causing enantiomer of the anti-malarial drug Lariam, has been resolved by Mosher ester crystallization. The configuration determined previously by physical methods is correct, while the configuration determined by three enantioselective syntheses is wrong.
van Tonder J J - - 2013
The organochlorine pesticide, dichlorodiphenyltrichloroethane (DDT), is still used to combat the spread of malaria in several developing countries despite its accumulation and known hepatotoxic effects that have been demonstrated both in vitro and in vivo. N-Acetylcysteine (NAC) is a recognized hepatoprotective agent that has been reported to reduce hepatotoxicity initiated ...
Stokes Alan H - - 2013
When conventional vehicles (eg, methylcellulose and water) impart inadequate physical, chemical, and/or biological properties for proper toxicological assessment of test article formulations, nonconventional vehicles may be considered. Often toxicity data for nonconventional vehicle formulations are limited. Studies were conducted to collect toxicity data from a rodent and a non-rodent species ...
Carere Jason - - 2013
HsaF and HsaG are an aldolase and dehydrogenase from the cholesterol degradation pathway of M. tuberculosis. HsaF could be heterologously expressed and purified as a soluble dimer, but the enzyme was inactive in the absence of HsaG. HsaF catalyzes the aldol cleavage of 4-hydroxy-2-oxoacids to produce pyruvate and an aldehyde. ...
Gingins Simon S Department of Biology, University of Neuchâtel, Emile-Argand 11, 2000 Neuchâtel, Switzerland. - - 2013
In many instances of cooperation, only one individual has both the potential and the incentive to 'cheat' and exploit its partner. Under these asymmetric conditions, a simple model predicts that variation in the temptation to cheat and in the potential victim's capacity for partner control leads to shifts between exploitation ...
Wildner Hendrik - - 2013
Inhibitory interneurons of the spinal dorsal horn play critical roles in the processing of noxious and innocuous sensory information. They form a family of morphologically and functionally diverse neurons that likely fall into distinct subtypes. Traditional classifications rely mainly on differences in dendritic tree morphology and firing patterns. Although useful, ...
Onushko Tanya T Department of Biomedical Engineering, Marquette University, Milwaukee, WI 53201-1881, - - 2013
Stretch-sensitive afferent feedback from hip muscles has been shown to trigger long-lasting, multijoint reflex responses in people with chronic spinal cord injury (SCI). These reflexes could have important implications for control of leg movements during functional activities, such as walking. Because the control of leg movement relies on reflex regulation ...
Pépin David - - 2013
Imitation Switch (ISWI) proteins are catalytic subunits of chromatin remodeling complexes that alter nucleosome positioning by hydrolyzing ATP to regulate access to DNA. In mice there are two paralogs, SNF2-homolog (SNF2H) and SNF2-like (SNF2L), which participate in different complexes and have contrasting patterns of expression. Here we investigate the role ...
Lam Kwok-Ho - - 2013
FliG and FliM are switch proteins that regulate the rotation and switching of the flagellar motor. Several assembly models for FliG and FliM have recently been proposed; however, it remains unclear whether the assembly of the switch proteins is conserved among different bacterial species. We applied a combination of pull-down, ...
de Graffenried Christopher L CL Max F. Perutz Laboratories, Center for Molecular Biology, University of Vienna, 1030 Vienna, Austria. - - 2013
In the protist parasite Trypanosoma brucei, the single Polo-like kinase (TbPLK) controls the inheritance of a suite of organelles that help position the parasite's single flagellum. These include the basal bodies, the bilobe, and the flagellar attachment zone (FAZ). TbCentrin2 was previously shown to be a target for TbPLK in ...
Ghafouri Hamed Basir - - 2013
BACKGROUND: The purpose of this study was to report interaction patterns among Iranian authors of emergency medicine using social network analysis methodology, focusing on coauthorship network. METHODS: The bibliographic data of Iranian authors on the 'emergency medicine' field during the years 2001-2011 were retrieved from the Science Citation Index Expanded ...
Kistemaker Hans A V - - 2013
The glycosylation properties of ribofuranosyl N-phenyltrifluoroacetimidates toward carboxamide side chains of asparagine and glutamine were investigated. Conditions were found that promote nearly exclusive formation of the α-anomerically configured N-glycosides. The strategy allows for the synthesis of Fmoc-amino acids suitably modified for the preparation of ADP-ribosylated peptides. Furthermore, ribosylation of serine ...
Simal-Gandara Jesus - - 2013
Quaternary Ammonium Herbicides (QUATs) are non-selective contact herbicides, widely used at weed emergence to protect a wide range of crops. The benefits achieved by the use of these herbicides are indisputable. In soils devoted to vineyards, their uses increase the yield and the quality of the grapes for winemaking. However, ...
Oberstein Paul E - - 2013
Gemcitabine was approved for advanced pancreatic cancer in 1996. We investigated uptake and predictors of its use. We identified 3,231 individuals > 65 years in the SEER-Medicare database with stage IV pancreatic adenocarcinoma, diagnosed between 1998-2005, who survived >30 days. Of these, 54% received chemotherapy, 93% with gemcitabine. Gemcitabine nonreceipt was associated with ...
Faure Emmanuel E Division of Biology, MC 156-29, California Institute of Technology, Pasadena, California, USA. - - 2013
The efficacy of a newly created software package for predictive modeling of developmental gene regulatory networks (GRNs) has recently been demonstrated (Peter et al., 2012 ). The program GeNeTool computes spatial gene expression patterns based on GRN interactions and thereby allows the direct comparison of predicted and observed spatial expression ...
Mistry Shailesh - - 2013
β-Adrenoceptor antagonists boast a 50-year use for symptomatic control in numerous cardiovascular diseases. One might expect highly selective antagonists are available for the human β-adrenoceptor subtype involved in these diseases; yet few truly β1- selective molecules exist. To address this clinical need, we re-evaluated LK 204-545 (1),1 a selective β1-adrenoceptor ...
Hazra Montu K - - 2013
We find that formic acid (FA) is very effective at facilitating diol formation through its ability to reduce the barrier for the formaldehyde (HCHO) hydrolysis reaction. The rate limiting step in the mechanism involves the isomerization of a prereactive collision complex formed through either the HCHO···H2O + FA and/or HCHO ...
Lerdweeraphon Wichaporn - - 2013
Perinatal exposure to taurine (a β-amino acid) can alter adult physiological functions, including arterial pressure, hormonal and renal. While perinatal taurine supplementation appears to have only minor effects on adult physiology, perinatal taurine depletion is associated with multiple adverse health effects, especially in animals postnatally exposed to other insults. New ...
Wuethrich Patrick Y - - 2013
OBJECTIVES.: Thoracic epidural analgesia (TEA) has been shown to inhibit detrusor activity in patients undergoing open renal surgery, resulting in clinically relevant post-void residuals. However, the impact of different epidural drug mixtures on urethral sphincter function is not completely elucidated. DESIGN.: Pooled analysis of an open observational study and a ...
Sakanashi Mayuko - - 2013
Background: Hormone replacement therapy has failed to reduce ischemic cardiovascular events in climacteric women. To explore alternative therapy, we examined whether san'o-shashin-to (TJ-113), a kampo medicine, ameliorates cardiac ischemia-reperfusion (IR) injury in a climacteric rat model. Methods and Results: Cardiac function and infarct size after IR were significantly exacerbated in ovariectomized rats ...
Jepson Lauren H - - 2013
Electrical stimulation of retinal neurons with an advanced retinal prosthesis may eventually provide high-resolution artificial vision to the blind. However, the success of future prostheses depends on the ability to activate the major parallel visual pathways of the human visual system. Electrical stimulation of the five numerically dominant retinal ganglion ...
Murillo Wendy W Microbiology Department, National Autonomous University of Honduras, Tegucigalpa, - - 2013
Human immunodeficiency virus type 1 (HIV-1) variants show considerable geographical separation across the world, but there is limited information from Central America. We provide the first detailed investigation of the genetic diversity and molecular epidemiology of HIV-1 in six Central American countries. Phylogenetic analysis was performed on 625 HIV-1 pol ...
Browne Edward P EP Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. - - 2013
Early events during retroviral infection play a critical role in determining the course of infection and pathogenesis, but the mechanisms that regulate this phase of infection are poorly understood. Toll-like receptor 7 (TLR7) is required for promoting germinal center reactions and virus-specific neutralizing antibodies at later time points postinfection, but ...
Haifeng Qiu - - 2013
PURPOSE: none EXPERIMENTAL DESIGN: none RESULTS: none CONCLUSIONS: none.
Twomey Michèle - - 2013
OBJECTIVE: To evaluate the construct of triage acuity as measured by the South African Triage Scale (SATS) against a set of reference vignettes. METHODS: A modified Delphi method was used to develop a set of reference vignettes. Delphi participants completed a 2-round consensus-building process, and independently assigned triage acuity ratings ...
Bucens Ingrid Kirsten - - 2013
AIM: The aim of this study was to undertake a retrospective review of admissions and discharges to the neonatal unit at the National Hospital Guido Valadares, Dili, in order to gain insight into the epidemiology of hospitalised neonates in East Timor, as the information cannot be obtained from the hospital ...
Liao Chia-Ding - - 2013
Mycotoxins in foods have long been recognized as a potential health hazard due to their toxic and carcinogenic properties. A simple and rapid method was developed to detect mycotoxins (aflatoxins, ochratoxins, fumonisins, trichothecenes and ergot alkaloids) in corn, rice, wheat, almond, peanut, and pistachio. Test portions of homogenized grains or ...
Heffernan Kevin S - - 2013
BACKGROUND: Time spent in sedentary pursuits such as sitting (SIT) is associated with an increased risk of cardiovascular disease independent of physical activity (PA). The purpose of this study was to examine the associations of PA and SIT with central hemodynamic burden in young adults. METHODS: Aortic pressure waveforms were ...
Huang Xiaoqing - - 2013
Reinventing the wheel: Bimetallic AuPd nanowheels, a freestanding form of 2D AuPd nanostructures, were synthesized in a one-pot process. The well-defined and tunable surface plasmon resonance displayed by these nanowheels was exploited in a unique catalytic process in which light energy was used to drive catalytic reactions, such as the ...
Vlachopoulos Charalambos - - 2013
Erectile dysfunction is common in the patient with cardiovascular disease. It is an important component of the quality of life and it also confers an independent risk for future cardiovascular events. The usual 3-year time period between the onset of erectile dysfunction symptoms and a cardiovascular event offers an opportunity ...
Wang De-Hui - - 2013
OBJECTIVES/HYPOTHESIS: To investigate how quickly an allergic rhinitis (AR) patients' symptoms will improve with sublingual immunotherapy (SLIT). STUDY DESIGN: Double-blind placebo study. METHODS: This is a multicenter, randomized, double-blind, placebo-controlled study of SLIT used to treat house dust mite-induced AR. A total of 120 AR patients, aged 4 to 60 ...
Kumar S Sudalai - - 2013
Cardiosulfa is a biologically active sulfonamide molecule that was recently shown to induce abnormal heart development in zebrafish embryos through activation of the aryl hydrocarbon receptor (AhR). The present report is a systematic study of solid-state forms of cardiosulfa and its biologically active analogues that belong to the N-(9-ethyl-9H-carbazol-3-yl)benzene sulfonamide ...
Niescierenko Michelle - - 2013
PURPOSE OF REVIEW: To review the advances in the assessment, treatment, and evaluation of care for pediatric dehydration. RECENT FINDINGS: Recent studies have added new information across the spectrum of care for dehydration. Advances in the assessment of dehydration allow more accurate clinical evaluation, but do not help predict the ...
Lovera Andrea - - 2013
Fano resonances in hybridized systems formed from the interaction of bright modes only are reported. Despite precedent works, we demonstrate theoretically and experimentally that Fano resonances can be obtained by destructive interference between two bright dipolar modes out of phase. A simple oscillator model is provided to predict and fit ...
Papanikolaou I S - - 2013
The 20th United European Gastroenterology Week (UEG week; 20 - 24 October 2012; Amsterdam, The Netherlands) offered, once again, the opportunity for delegates interested in gastrointestinal endoscopy to update their knowledge as colleagues from all over the world shared their experiences. Various interesting studies on endoscopic topics were presented, allowing ...
Anand Sneha N SN MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, United - - 2013
The circadian clock of the suprachiasmatic nucleus (SCN) drives daily rhythms of behavior. Cryptochromes (CRYs) are powerful transcriptional repressors within the molecular negative feedback loops at the heart of the SCN clockwork, where they periodically suppress their own expression and that of clock-controlled genes. To determine the differential contributions of ...
Mosbech Anna A Ubiquitin Signaling Group, Department of Disease Biology, The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, - - 2013
Protein recruitment to DNA double-strand breaks (DSBs) relies on ubiquitylation of the surrounding chromatin by the RING finger ubiquitin ligases RNF8 and RNF168. Flux through this pathway is opposed by several deubiquitylating enzymes (DUBs), including OTUB1 and USP3. By analyzing the effect of individually overexpressing the majority of human DUBs ...
Kim Tae Han - - 2013
Abstract Background: The preemptive intravenous injection of local anesthetics is known to improve postoperative pains in abdominal surgery. The aim of this study is to assess the effect of intravenous lidocaine injection and analyze the precise amount of pain by computerized patient-controlled analgesia (PCA) in patients who had undergone laparoscopy-assisted ...
Ahmadi Khodabakhsh - - 2013
Abstract In the present study, factors that could play an important role in Internet addiction (IA) in 4,177 Iranian high school and secondary school adolescents (age range: 14-19 years) were examined. Data for the present study were gathered through Young's IA test, the General Health Questionnaire (GHQ), and family relationship ...
Barry Jessica - - 2013
Allergic asthma is a chronic inflammatory disease predominately associated with the activation of CD4+ T helper type 2 (Th2) cells. Additionally, it is widely acknowledged that innate pattern recognition receptors shape the adaptive immune response. For example, the activation of airway epithelial TLR4 is necessary for the generation of house ...
Green Timothy J - - 2013
Mandatory folic acid fortification of grains such as wheat flour has been introduced in several countries to reduce the incidence of neural tube defects. There are concerns, however, that folic acid could mask the hematologic signs of vitamin B-12 deficiency and lead to other adverse health outcomes in the population. ...
Iwase Shohei S Department of Nanobiology, Graduate School of Advanced Integration Science, Chiba University, Chiba 263-8522, - - 2013
We identify Xenopus ADF/cofilin (XAC) and its activator, Slingshot phosphatase (XSSH), as key regulators of actin dynamics essential for spindle microtubule assembly during Xenopus oocyte maturation. Phosphorylation of XSSH at multiple sites within the tail domain occurs just after germinal vesicle breakdown (GVBD) and is accompanied by dephosphorylation of XAC, ...
Yu Haijun - - 2013
About phase: The coexistence of rhombohedral LiTMO2 (TM=Ni, Co, or Mn) and monoclinic Li2 MnO3 -like structures inside Li1.2 Mn0.567 Ni0.166 Co0.067 O2 is revealed directly at atomic resolution. The hetero-interface along the [001]rh /[103]mon zone axis direction is demonstrated, indicating the two-phase nature of these lithium-rich cathode materials (green ...
White Katharine Alice - - 2013
Previously, we reported a new method for intracellular protein labeling in living cells called PRIME (PRobe Incorporation Mediated by Enzymes). PRIME uses a mutant of Escherichia coli lipoic acid ligase (LplA) to catalyze covalent probe ligation onto a 13-amino acid peptide recognition sequence. While our first demonstration labeled proteins with ...
Neace Calvin J CJ School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, - - 2013
There is a need for a point-of-care serodiagnostic test for women and men for sexually transmitted infections (STIs) caused by Trichomonas vaginalis. Sera from women with this STI and sera from men that were analyzed in studies showing a relationship between serostatus and prostate cancer are highly seropositive in response ...
Nguyen Thao K N - - 2013
Proteoglycans (PGs) modulate numerous signaling pathways during development through binding of their glycosaminoglycan (GAG) side chains to various signaling molecules including fibroblast growth factors (FGFs). A majority of PGs possess two or more GAG side chains suggesting that GAG multivalency is imperative for biological functions in vivo. However, only a ...
Schwartz Stanley S - - 2013
Abstract The position statement on the management of hyperglycemia in patients with type 2 diabetes mellitus issued in 2012 by the American Diabetes Association and the European Association for the Study of Diabetes contains significant improvements over the 2009 version, including an emphasis on patient-centered care, enhanced strategies for lifestyle ...
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