Search Results
Results 751 - 800 of 2366
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Castle David - - 2013
OBJECTIVE: To review the contemporary landscape regarding pharmacological treatments for schizophrenia. METHOD: Selective literature review. RESULTS: Newer antipsychotic agents include aripiprazole, asenapine, paliperidone, sertindole and ziprasidone. Each has some particular benefits and some shortcomings. Overall treatment efficacy (for positive symptoms at least) has not advanced substantially but some newer agents ...
Bruvik Frøydis Kristine - - 2013
Objectives: This study explores the association between coping, measured by the extent of locus of control, and the burden of care on family carers of persons with dementia (PWD). Method: Two hundred thirty PWD living at home and their family carers were recruited from 20 Norwegian municipalities. The carers' burden ...
Sosunov Alexander A - - 2013
Alexander Disease (AxD) is a primary disorder of astrocytes, caused by heterozygous mutations in GFAP, which encodes the major astrocyte intermediate filament protein, glial fibrillary acidic protein (GFAP). Astrocytes in AxD display hypertrophy, massive increases in GFAP, and the accumulation of Rosenthal fibers, cytoplasmic protein inclusions containing GFAP, and small ...
Bonekamp Susanne S Department of Radiology, Johns Hopkins School of Medicine, the Johns Hopkins Hospital, 600 N Wolfe St, MRI 143, Baltimore, MD 21287, - - 2013
To assess whether volumetric functional magnetic resonance (MR) results 3-4 weeks after initial intraarterial therapy can aid accurate distinction between responders and nonresponders, to determine whether overall survival (OS) is improved, and to compare volumetric functional MR response with anatomic response criteria (Response Evaluation Criteria in Solid Tumors [RECIST], modified ...
Wen Zhenke - - 2013
Anti-dsDNA Ab is reported to be the central pathogenic autoantibody involved in systemic lupus erythematosus (SLE) pathogenesis. However, the mechanisms involved in anti-dsDNA Ab production remain unclear. Recent evidence indicated that DNA-containing immune complexes (ICs) in circulation (termed "circulating DNA-containing ICs"), which are one of the hallmarks of SLE, might ...
Watanabe Eiki - - 2013
An original extraction method using water as an extractant has been established for environmentally friendly sample preparation procedures for hydrophilic pesticides (acetamiprid, clothianidin, dinotefuran, flonicamid, imidacloprid, methomyl, pymetrozine, thiacloprid, and thiamethoxam) in agricultural samples with conventional HPLC. Water-based extraction and clean-up with two solid-phase extraction cartridges can recover target hydrophilic ...
Byrne Rosemary J - - 2013
The genus Leuresthes displays reproductive behavior unique among marine fish in which mature adults synchronously emerge completely out of the water to spawn on beach land. A limited number of sandy beaches, which are suitable for these spawning events, are present in discontinuous locations along the geographic range of the ...
Priestap Horacio A - - 2013
Aristolochic acid I (AA-I), naturally occurring in Aristolochia plants, is a potent nephrotoxin and carcinogen. Here we report that AA-I suffers hydrogenolysis with loss of the nitro group by reaction with cysteine or glutathione to give aristolic acid. Since the reaction can proceed in aqueous solutions at pH 7.0 and ...
Sabbah Shai - - 2013
Polarization sensitivity (PS) in vertebrate vision is controversial, perhaps because its underlying mechanism has remained obscure. An issue that might have added to the controversy is that rainbow trout (Oncorhynchus mykiss), which have served as the primary model system for polarization-based orientation, lose their ability to orient relative to celestial ...
Qiu Xiangguo X Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada. - - 2013
Monoclonal antibodies (MAbs) are currently a promising treatment strategy against Ebola virus infection. This study combined MAbs with an adenovirus-vectored interferon (DEF201) to evaluate the efficacy in guinea pigs and extend the treatment window obtained with MAbs alone. Initiating the combination therapy at 3 days postinfection (d.p.i.) provided 100% survival, ...
Turner Martin R MR University of Oxford Nuffield Department of Clinical Neurosciences, Oxford, UK. - - 2013
The progression of motor neurone disease (MND) is currently irreversible, and the grave implications of diagnosis naturally fuels concern among neurologists over missing a potential mimic disorder. There is no diagnostic test for MND but in reality there are few plausible mimics in routine clinical practice. In the presence of ...
Capasso Giovambattista - - 2013
The proximal tubule uses a complex process of apical acid secretion and basolateral bicarbonate absorption to regulate both luminal acidification and fluid absorption. One of the primary regulators of apical acid secretion is the luminal sodium-hydrogen exchanger expressed along the apical membrane of the proximal tubule. Similarly, the calcium-sensing receptor ...
Baysal Asli - - 2013
Objective:The aim of this study is to evaluate dentoskeletal effects of Herbst and Twin Block (TB) appliance therapies in Skeletal Class II malocclusion.Subjects and Methods:Herbst group consisted of 11 girls and 9 boys (mean age = 12.74±1.43 years), TB group comprised of 10 girls and 10 boys (mean age = ...
Kunte Amit A Section of Infectious Diseases, Department of Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520-8011, - - 2013
The non-classical major histocompatibility complex (MHC) homologue CD1d presents lipid antigens to innate-like lymphocytes called natural-killer T (NKT) cells. These cells, by virtue of their broad cytokine repertoire, shape innate and adaptive immune responses. Here, we have assessed the role of endoplasmic reticulum glycoprotein quality control in CD1d assembly and ...
Trotta Mauricio de Rosa - - 2013
Liver resection is a suitable option for the treatment of certain hepatic conditions, particularly hepatocarcinomas, in patients with cirrhosis. However, this disease impairs liver regeneration, which increases the risk of liver failure and postoperative death. Supportive treatments for regeneration of the remaining liver may be useful for the recovery of ...
Schnepf Nathalie N Université Paris Diderot, Pres Sorbonne Paris Cité, INSERM U941, APHP, Microbiology Laboratory, Hôpital Saint-Louis, Paris, - - 2013
Fully standardized reproducible and sensitive quantification assays for cytomegalovirus (CMV) are needed to better define thresholds for antiviral therapy initiation and interruption. We evaluated the newly released Abbott RealTime CMV assay for CMV quantification in whole blood (WB) that includes automated extraction and amplification (m2000 RealTime system). Sensitivity, accuracy, linearity, ...
Swanston Jennifer - - 2013
Millions of children are exposed to domestic violence. How children negotiate and make sense of living with domestic violence is still under-researched. This study sought to capture the dual-perspectives of school-aged children and their mothers, to develop a richer understanding of children's experiences of domestic violence, using a community-based sample. ...
Esser Eva - - 2013
Abdominal adhesions are one of the major problems associated with abdominal surgeries or abdominal trauma. There are many different therapeutic options to prevent these adhesions, for example, the application of barrier films made of biodegradable polymers like alginate. For many application relevant parameters (mechanical stability, elasticity, erosion, and mucoadhesivity of ...
Soares Bruno Meira - - 2013
This paper reports, for the first time, the development of an analytical method employing modified matrix solid-phase dispersion (MSPD) for the extraction of CH3Hg+ and Hg2+ species from fish samples. Separation and determination of mercury species were performed by gas chromatography coupled to mass spectrometry (GC-MS). Important MSPD parameters, such ...
van Geemen Kim - - 2013
Objectives: Despite previous lesional and functional neuroimaging studies, the actual role of the left ventral premotor cortex (vPMC), i.e., the lateral part of the precentral gyrus, is still poorly known. Experimental design:We report a series of eight patients with a glioma involving the left vPMC, who underwent awake surgery with ...
Haus Jacob M JM Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, - - 2013
Hepatic steatosis, insulin resistance, inflammation, low levels of polyunsaturated lipids, and adiponectin are implicated in the development and progression of nonalcoholic fatty liver disease (NAFLD). We examined the effects of short-term aerobic exercise on these metabolic risk factors. Obese individuals (N = 17, 34.3 ± 1.0 kg/m²) with clinically confirmed ...
Lindsay Sally - - 2013
ABSTRACT Purpose: Evidence shows that effective self-management behaviors have the potential to improve health outcomes, quality of life, self-efficacy and reduce morbidity, emergency visits and costs of care. A better understanding of self-management interventions (i.e. programs that help with managing symptoms, treatment, physical and psychological consequences) is needed to achieve ...
Panconesi Alessandro - - 2013
OBJECTIVE.: This project aims to investigate the role of alcoholic drinks (ADs) as triggers for primary headaches. METHODS.: Patients followed in the Headache Centre and presenting with migraine without aura, migraine with aura (MA), chronic migraine (CM), and tension-type headache (TH) were asked if their headache was precipitated by AD ...
Chen Qi - - 2013
There are ongoing debates on the direction of sensory dominance in cross-modal interaction. In the present study, we demonstrate that the specific direction of sensory dominance depends on the level of processing: vision dominates at earlier stages, whereas audition dominates at later stages of cognitive processing. Moreover, these dominances are ...
McCabe Áine Á Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, - - 2013
Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia (ATL). The viral regulatory protein Tax1 plays a pivotal role in T-cell transformation and ATL development. Previous studies in our laboratory, using the yeast 2-hybrid approach to screen a T-cell library for Tax1-interacting partners, identified ...
Choi Sun Hee SH Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, - - 2013
In pea carrying cyv1, a recessive gene for resistance to Clover yellow vein virus (ClYVV), ClYVV isolate Cl-no30 was restricted to the initially infected cells, whereas isolate 90-1 Br2 overcame this resistance. We mapped the region responsible for breaking of cyv1-mediated resistance by examining infection of cyv1 pea with chimeric ...
Grigoryan Gayane - - 2013
Long term effects of stress during pregnancy on brain and behavior have been analyzed extensively in recent years. These effects include changes in emotional behavior, a reduction in learning capacity and ability to generate long-term potentiation (LTP) in the offspring. In earlier studies we and others have described a difference ...
Liao Chunyang - - 2013
As the concern over the safety of bisphenol A (BPA) continues to grow, this compound is gradually being replaced, in industrial applications, with compounds such as bisphenol F (BPF) and bisphenol S (BPS). Occurrence of bisphenols, including BPA and BPS, has been reported in paper products and in environmental matrices. ...
Bradley Emma L - - 2013
Methodology for the determination of 15 phthalate diesters (dimethyl phthalate, diethyl phthalate, diisopropyl phthalate, diallyl phthalate, diisobutyl phthalate, di-n-butyl phthalate, di-n-pentyl phthalate, di-n-hexyl phthalate, benzyl butyl phthalate, dicyclohexyl phthalate, di-(2-ethylhexyl) phthalate, di-n-octyl phthalate, diisononyl phthalate, diisodecyl phthalate, and di-n-decyl phthalate) is described. The method was validated in-house and its broad ...
Rafat Cédric - - 2013
Introduction: Levofloxacin , the l-isomer of ofloxacin has become one of the cornerstones of antibiotic therapy of pyelonephritis since its introduction in the 1990s, thanks to its exceptional pharmacokinetic (PK) and pharmacodynamic (PD) profile, broad-spectrum antibacterial action and satisfactory tolerance. However, the emergence of widespread fluoroquinolone resistance over the past ...
Gahche Jaime J JJ Centers for Disease Control and Prevention/National Center for Health Statistics, Division of National Health and Nutrition Examination Surveys, Hyattsville, MD, USA. - - 2013
During pregnancy, the iodine requirement rises to meet demands for neurological development and fetal growth. If these requirements are not met, irreversible pathological cognitive and behavioral changes to the fetus may ensue. This study estimated the prevalence of iodine-containing dietary supplement (DS) use and intakes of iodine from DSs among ...
Dubey Amit - - 2013
Probabilistic models of sentence comprehension are increasingly relevant to questions concerning human language processing. However, such models are often limited to syntactic factors. This restriction is unrealistic in light of experimental results suggesting interactions between syntax and other forms of linguistic information in human sentence processing. To address this limitation, ...
Sharma Veerendra Kumar - - 2013
Micellar dynamics in Sodium Dodecyl Benzene Sulfonate (SDBS) is studied using quasi-elastic neutron scattering (QENS) technique. Results are compared with Sodium Dodecyl Sulfate (SDS), a very similar surfactant except for the presence of a phenyl ring in SDBS. SDBS is a very important system for various industrial usages and variety ...
Kral Rosana Maria - - 2013
Sprouty1 protein belongs to a family of receptor tyrosine kinase-mediated signaling inhibitors, whose members are usually regulated by growth factors to form a negative feedback loop. Correspondingly fluctuations of Sprouty1 mRNA in response to single growth factors have been observed. In this report, we investigate Sprouty1 protein levels and show ...
Emami Nader - - 2013
OBJECTIVES/HYPOTHESIS: Olive oil is often used by patients to soften ear wax or to relieve ear canal obstruction. It is also sold in drugstores as a cerumenolytic. To date, no study has assessed the safety of ototopical olive oil on hearing in the presence of tympanic membrane perforation. The present ...
Busatto Geraldo F GF Department of Psychiatry, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. - - 2013
The relationship between major depressive disorder with psychotic (MDDP) features and schizophrenia has long been recognized, and the neurobiological boundaries between these disorders can nowadays be investigated using neuroimaging techniques. This article provides a critical review of such studies, addressing how they support a dimensional approach to the nosology and ...
Klymenko Oleksiy V - - 2013
The validity and accuracy of our new numerical approach implemented in KISSA-1D software when applied to a theoretical study of different types of electrochemiluminescence (ECL) is established by comparison with existing analytical solutions and others specifically derived in this work, as well as with independent numerical solutions obtained by using ...
Takanashi Yuma - - 2013
The properties of polymer ultrathin films are a subject of intense study from both practical and academic viewpoints. Previously, we found that upon compression, an isotactic poly(methyl methacrylate) (it-PMMA) Langmuir monolayer crystallized to form a two-dimensional (2D) folded-chain crystal, and the molecular image of the crystal with chain folding and ...
Abdulnour Joseph - - 2013
Objective: To measure the circulating levels of endocannabinoids and related molecules at fasting, after acute hyperinsulinemia and after weight loss in insulin sensitive vs. insulin resistant obese postmenopausal women. Design and Methods: The sample consisted of 30 obese postmenopausal women (age: 58.9±5.2 yrs; BMI: 32.9±3.6 kg/m(2) ). Subjects underwent a ...
Haiges Ralf - - 2013
Salts of bis(3,5-dinitro-1H-1,2,4-triazolyl)dihydro- and dichloroborate and bis(5-nitro-2H-tetrazolyl)-, bis(5-trinitromethyl-2H-tetrazolyl)-, and bis(5-fluorodinitromethyl-2H-tetrazolyl)dihydroborate anions have been synthesized by the treatment of hydroborates or chloroborates with the corresponding nitroazoles or nitroazolates, respectively. Alkali-metal salts of these dihydroborates are energetic and can be shock-sensitive, while salts with larger organic cations, such as NMe4(+), PPh4(+), or ...
Partridge Brian C - - 2013
Moral and legal notions engaged in clinical ethics should not only possess analytic clarity but a sound basis in empirical findings. The latter condition brings into question the expansion of the mature minor exception. The mature minor exception in the healthcare law of the United States has served to enable ...
Riskin Arieh - - 2013
Objective To study the influence of policy changes in the evaluation of neonatal hyperbilirubinemia on discharge process from the nursery. Changes included early assessment of risk factors by universal umbilical blood sampling for blood type, Coombs test, and glucose-6-phosphate dehydrogenase (G6PD) and universal noninvasive transcutaneous bilirubinometry at discharge.Study Design The ...
Halpern Casey H - - 2013
Hedonic overconsumption contributing to obesity involves altered activation within the mesolimbic dopamine system. Dysregulation of dopamine signaling in the nucleus accumbens shell (NAS) has been implicated in reward-seeking behaviors, such as binge eating, which contributes to treatment resistance in obesity (Wise, 2012). Direct modulation of the NAS with deep brain ...
Allen Vivian - - 2013
Locomotion in living birds (Neornithes) has two remarkable features: feather-assisted flight, and the use of unusually crouched hindlimbs for bipedal support and movement. When and how these defining functional traits evolved remains controversial. However, the advent of computer modelling approaches and the discoveries of exceptionally preserved key specimens now make ...
Wachs Israel E - - 2013
Supported vanadium oxide catalysts contain a vanadium oxide phase deposited on a high surface area oxide support (e.g., Al2O3, SiO2, TiO2, etc.) and have found extensive applications as oxidation catalysts in the chemical, petroleum and environmental industries. This review of supported vanadium oxide catalysts focuses on the fundamental aspects of ...
El Gabaly Farid - - 2013
Nickel is the most commonly used anode for solid-oxide fuel cells (SOFC) due to its fast kinetics and low price. A leading cause of degradation in Ni electrodes is oxidation. Here we use operando ambient-pressure X-ray photoelectron spectroscopy (XPS) to chemically characterize the Ni electrode of a fuel cell anode ...
Aardema Hilde - - 2013
Metabolic conditions characterized by elevated free fatty acid concentrations in blood and follicular fluid are often associated with impaired female fertility. Especially elevated saturated fatty acid levels can be lipotoxic for several somatic cell types. The aim of this study was to determine the impact of elevated free fatty acid ...
Tebbs Irene R - - 2013
Eukaryotic cells require IQGAP family multi-domain adapter proteins for cytokinesis, but many questions remain about how IQGAPs contribute to the process. Here we show that fission yeast IQGAP Rng2p is required for both the normal process of contractile ring formation from precursor nodes and an alternative mechanism where rings form ...
Chung Kyung-Sook - - 2013
Previously, we reported that CWJ-082 (6,7-dimethoxy-3-(3-methoxyphenyl)isoquinolin-1-amine) has potent cytotoxic effects on various cancer cells, but the underlying molecular mechanism responsible was not determined. In the present study, CWJ-082 caused cervical cancer cell cycle arrest at the G2/M phase and subsequent caspase-dependent apoptosis. The mitotic arrest caused by CWJ-082 found to ...
Meuti Megan E ME Department of Entomology, The Ohio State University, Columbus, OH 43210, USA. - - 2013
In this article, we explore links between circadian clocks and the clock involved in photoperiodic regulation of diapause in insects. Classical resonance (Nanda-Hamner) and night interruption (Bünsow) experiments suggest a circadian basis for the diapause response in nearly all insects that have been studied. Neuroanatomical studies reveal physical connections between ...
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