Search Results
Results 701 - 750 of 2366
< 10 11 12 13 14 15 16 17 18 19 20 >
Fischer Michael J M - - 2013
Transient receptor potential vanilloid subtype 1 (TRPV1) is a heat-sensitive ion channel that plays a key role in enhanced pain sensation after inflammation, but directly blocking TRPV1 causes hyperthermia and decreased sensitivity to painful levels of heat in animals and humans. Here we explore an alternative analgesic strategy in which ...
Chang D-H - - 2013
Purpose: Evaluation of complications, patient satisfaction and clinical benefit of port systems with authorization for high pressure injection of contrast agent during CT/MR examinations. Materials and Methods: Ultrasound-guided insertions of central venous port catheters were performed through the lateral subclavian vein at a university teaching hospital. The radiological information system ...
Thanyasiriwat T - - 2013
Starch pasting viscosity is an important quality trait in cassava (Manihot esculenta Crantz) cultivars. The aim here was to identify loci and candidate genes associated with the starch pasting viscosity. Quantitative trait loci (QTL) mapping for seven pasting viscosity parameters was carried out using 100 lines of an F1 mapping ...
Aoki Sho - - 2013
During locomotion, stepping over an obstacle under visual guidance is crucial to continuous safe walking. Studies of the role of the central nervous system in stepping movements have focused on cerebral cortical areas such as the primary motor cortex and posterior parietal cortex. There is speculation that the lateral cerebellum, ...
Lee Tai-Sung TS Center for Integrative Proteomics Research, The State University of New Jersey, 174 Frelinghuysen Rd., Piscataway, NJ 08854, USA. - - 2013
Janus kinase 2 (JAK2) is a protein tyrosine kinase central to a multitude of cellular processes. Here, a novel model of JAK2 regulation and activation is proposed. In the JAK2 dimer, instead of being auto-inhibited by its own JH2 domain, inhibition comes from the JH2 domain of the partnering JAK2 ...
Petrenko Natalia - - 2013
All cells perceive and respond to environmental stresses through elaborate stress-sensing networks. Yeast cells sense stress through diverse signaling pathways that converge on the transcription factors Msn2 and Msn4, which respond by initiating rapid, idiosyncratic cycles into and out of the nucleus. To understand the role of Msn2/4 nuclear localization ...
Durante-Mangoni Emanuele E Internal Medicine Section, Department of Cardiothoracic Sciences, University of Naples S.U.N. and AORN Ospedali dei Colli, Monaldi Hospital, - - 2013
Extensively drug-resistant (XDR) Acinetobacter baumannii may cause serious infections in critically ill patients. Colistin often remains the only therapeutic option. Addition of rifampicin to colistin may be synergistic in vitro. In this study, we assessed whether the combination of colistin and rifampicin reduced the mortality of XDR A. baumannii infections ...
Hainsworth John D - - 2013
Purpose: To evaluate the feasibility and efficacy of sorafenib and everolimus in renal cell carcinoma (RCC). Methods: Patients with advanced RCC and ≤1 previous targeted therapy were treated. Results: Maximum tolerated doses were sorafenib 200 mg PO BID, everolimus 35 mg PO once weekly. Dose-limiting toxicity was hand-foot syndrome. The response rate ...
Wang Cong-Jun - - 2013
Abstract Pancreatic cancer is an aggressive malignancy with a five-year mortality of 97-98% due to widespread metastatic disease. A better understanding of the molecular mechanism of pancreatic cancer is beneficial for the development of novel approaches for early detection and monitoring of pancreatic cancer. We aim to comprehensively identify the ...
Ragg Mark - - 2013
OBJECTIVE: This review sought to determine whether quitting smoking behaviour places people with a history of schizophrenia or major depression at risk of worsening symptoms or relapse. METHOD: Literature searches of Embase, MEDLINE, the Cochrane Library and PsycINFO. RESULTS: Six studies involving 735 people diagnosed with schizophrenia, schizoaffective disorder or ...
Rettenmeier Eva - - 2013
When an ynamide meets a gold carbenoid: Highly electrophilic gold carbenoids available from propargylic esters by means of 1,2-acyloxy migration open up new reaction pathways for ynamide gold chemistry. In this way highly functionalized cyclopentadiene derivatives become accessible (see scheme; EWG=electron-withdrawing group).
Vissing Christoffer Rasmus - - 2013
Mitochondrial myopathies commonly present with exercise intolerance typified by breathlessness and fatigue on exercise. In contrast, exercise-induced rhabdomyolysis and myoglobinuria occur rarely. We present a 43-year-old man with a lifelong history of exercise intolerance associated with myalgia and recurrent episodes of exercise-induced myoglobinuria. From early childhood, he had weekly episodes ...
Mul Joram D JD Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH 45327, - - 2013
Overconsumption of a high-fat diet promotes weight gain that can result in obesity and associated comorbidities, including Type 2 diabetes mellitus. Consumption of a high-fat diet also alters gut-brain communication. Glucagon-like peptide 1 (GLP-1) is an important gastrointestinal signal that modulates both short- and long-term energy balance and is integral ...
Yang Z - - 2013
Cardiovascular disease (CVD) is one of the most common chronic diseases in China. This aim of this study is to determine the prevalence of CVDs and risk factors in Chinese impaired glucose regulation subjects.We used a multistage, stratified sampling method to select subjects from the general Chinese population aged 20 ...
Beehler Gregory P - - 2013
OBJECTIVE.: Patients with chronic pain have been shown to be more frequent utilizers of primary care, a contributor to increased health care costs. This study aimed to clarify which patient factors predict primary care utilization among veterans with chronic pain. DESIGN.: Data were gathered from the electronic medical records of ...
Borella Erika - - 2013
The present study examined the efficacy of a verbal working memory (WM) training program in old-old individuals (over 75 years of age). Thirty-six adults aged 75-87 took part in the study: 18 were randomly assigned to receive training and the remainder served as active controls. Specific training gains in a ...
Salas Monica - - 2013
Resveratrol acts as a chemopreventive agent for cancer and as a potential anti-obesity and anti-diabetic compound, by leading to reduced body fat and improved glucose homeostasis. The exact mechanisms involved in improving hyperglycemic state are not known, but most of glucose uptake into mammalian cells is facilitated by the GLUT ...
Georgantas V - - 2013
Synthetic efforts linked to the design of defined lattice dimensionality and architecture materials in the binary/ternary systems of Cu(II) with butylene diamine tetra(methylene phosphonic acid) (H8BDTMP) and heterocyclic organic chelators (pyridine and 1,10-phenanthroline) led to the isolation of new copper organophosphonate compounds, namely, Na6[Cu2(BDTMP)(H2O)4]·[Cu2(BDTMP)(H2O)4]0.5·26H2O (1), [Cu2(H4BDTMP)(py)4]·2H2O (2), and [Cu2(H4BDTMP)(phen)2]n·6.6nH2O·1.5nMeOH (3). ...
Charo Israel F - - 2013
Despite the impressive success of HMG-CoA reductase inhibitors (statins) in lowering cholesterol levels, atherosclerotic heart disease remains the leading cause of death in the Western world. Although a central role for cholesterol, particularly LDL-cholesterol in atherogenesis is undisputed, other contributing factors likely include diabetes mellitus, triglycerides, oxidation of proteins and/or ...
Heidenreich Paul A - - 2013
Heart failure (HF) is an important contributor to both the burden and cost of national healthcare expenditures, with more older Americans hospitalized for HF than for any other medical condition. With the aging of the population, the impact of HF is expected to increase substantially. We estimated future costs of ...
Zeng Dexing D Department of Radiology, Molecular Imaging Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, - - 2013
Click chemistry has become a ubiquitous chemical tool with applications in nearly all areas of modern chemistry, including drug discovery, bioconjugation, and nanoscience. Radiochemistry is no exception, as the canonical Cu(I)-catalyzed azide-alkyne cycloaddition, strain-promoted azide-alkyne cycloaddition, inverse electron demand Diels-Alder reaction, and other types of bioorthogonal click ligations have had ...
Seplaki Christopher L - - 2013
PURPOSE: A primary goal for aging policy is to optimize independence in later life. We estimate the cross-sectional association between physical and social challenge in the home environment and use of assistive devices (AD) for mobility in the home, controlling for lower extremity physical performance (short physical performance battery [SPPB]) ...
Mialki Rachel K RK Department of Medicine and the Acute Lung Injury Center of Excellence, the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, - - 2013
The ubiquitin-proteasome system is the major pathway of non-lysosomal intracellular protein degradation, playing an important role in a variety of cellular responses including cell division, proliferation, and apoptosis. Ubiquitin-specific protease 14 (USP14) is a component of proteasome regulatory subunit 19 S that regulates deubiquitinated proteins entering inside the proteasome core ...
Jones Matthew C - - 2013
The Rho family of GTPases plays an important role in coordinating dynamic changes in the cell migration machinery following integrin engagement with the extracellular matrix. Rho GTPases are activated by guanine nucleotide exchange factors (GEFs) and negatively regulated by GTPase activating proteins (GAPs). However, the mechanisms by which GEFs and ...
Wang Lei - - 2013
The POU transcription factor OCT4 is a pleiotropic regulator of gene expression in embryonic stem cells. Recent studies demonstrated that OCT4 is aberrantly expressed in multiple types of human cancer; however, the underlying molecular mechanism remains largely unknown. In this study, we report that OCT4-pg4, a pseudogene of OCT4, is ...
Russo Richard E - - 2013
Laser ablation for chemical analysis offers elemental, isotopic and classification analysis, minimal or no sample preparation, no consumables, rapid turn-around time, and chemical interrogation of H-Pu from any sample. Simply remove (ablate) a tiny portion of mass from a sample using a pulsed laser beam and subsequently analyze optical emission ...
Li Yajun - - 2013
A highly efficient method for the synthesis of fluorine-containing multisubstituted phenanthridines through Rh-catalyzed alkyne [2+2+2] cycloaddition reactions has been developed. This method exhibits excellent functional-group compatibility. When a bromodifluoromethyl group, rather than a trifluoromethyl group, was employed in the cycloaddition reaction, more-complicated polycyclic compounds were obtained through tandem Rh-catalyzed cycloaddition/CH ...
Voyer Benjamin G - - 2013
AIM: To compare the self-construal of nurses and doctors and establish whether their roles affect perceptions of independence and interdependence. BACKGROUND: Previous research has identified that errors in patient care occur when health professionals do not work cohesively as a team and have divergent beliefs about collaboration. Thus, it is ...
Murtomaki Aino A Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY 10032, - - 2013
In development, lymphatic endothelial cells originate within veins and differentiate via a process requiring Prox1. Notch signaling regulates cell-fate decisions, and expression studies suggested that Jag1/Notch1 signaling functions in veins during lymphatic endothelial specification. Using an inducible lymphatic endothelial Prox1CreER(T2) driver, Notch signaling was suppressed by deleting Notch1 or expressing ...
Langer Jacob C - - 2013
PURPOSE OF REVIEW: Hirschsprung disease is relatively common in children. Surgical techniques are available to remove the aganglionic bowel and reconstruct the intestinal tract. Despite many advances, these children may still be difficult to diagnose, and may have ongoing functional problems after surgical correction. RECENT FINDINGS: The genetic basis and ...
Kölmel Dominik K - - 2013
Incorporation of fluorous ponytails such as polyfluorinated alkyl residues (CH2)m(CF2)nCF3 leads to a novel class of bright rhodamine-based fluorescence dyes. These dyes combine the excellent photophysical properties of the frequently used rhodamine dyes with the unique features of "light" fluorous molecules. One of those features is the possibility to separate ...
Gill Richard - - 2013
OBJECTIVE: Obesity is a major public health problem that increases risk for a broad spectrum of co-morbid conditions. Despite evidence for a strong genetic contribution to susceptibility to obesity, previous efforts to discover the relevant genes using positional cloning have failed to account for most of the apparent genetic risk ...
Kruit Mark C MC Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands. - - 2013
We and others showed that migraineurs are at increased risk of subclinical and clinical ischemic brain lesions. Migraineurs also have a higher prevalence of frequent syncope and orthostatic intolerance, symptoms that are associated with transient reductions in cerebral blood flow. In this study, we assessed whether these autonomic symptoms may ...
Alfonso Ana - - 2013
Extensive screening strategies to detect occult cancer in patients with unprovoked venous thromboembolism (VTE) are complex and no benefit in terms of survival has been reported. FDG-PET/CT, a non-invasive technique for the diagnosis and staging of malignancies, could be useful in this setting. Consecutive patients ≥ 50 years with a ...
Hansen Helena B HB New York University, New York City, NY, USA. - - 2013
At stake in the May 2013 publication of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), are billions of dollars in insurance payments and government resources, as well as the diagnoses and treatment of millions of patients. We argue that the most recent revision process has missed ...
Esterberg Robert - - 2013
Intracellular Ca(2+) is a key regulator of life or death decisions in cultured neurons and sensory cells. The role of Ca(2+) in these processes is less clear in vivo, as the location of these cells often impedes visualization of intracellular Ca(2+) dynamics. We generated transgenic zebrafish lines that express the ...
Niyomchon Supaporn - - 2013
Catalytic asymmetric allylation of lactone 1 with allyl boronates leads to functionalized cyclobutenes in high regio- and stereoselectivity.
Smarandache-Wellmann Carmen C Institute of Zoology, University of Cologne, Cologne, - - 2013
We conducted a quantitative analysis of the different nonspiking interneurons in the local pattern-generating circuits of the crayfish swimmeret system. Within each local circuit, these interneurons control the firing of the power-stroke and return-stroke motor neurons that drive swimmeret movements. Fifty-four of these interneurons were identified during physiological experiments with ...
Moric-Janiszewska Ewa - - 2013
The opportunity to distinguish an accurate set of genes associated with multigenic diseases such as cardiomyopathies or cardiac arrhythmias was very limited before the genomic era. Numerous methods of measuring RNA abundance exist, including northern blotting, multiplex polymerase chain reaction (PCR), and quantitative real-time reverse transcriptase-PCR. However, these techniques might ...
Popov Aleksandra - - 2013
Abstract Allergic contact dermatitis (ACD) is a common skin inflammatory disease that develops in hosts sensitized with contact allergens. Elucidation of dose-response relationships represents one of the approaches in studying the type of ACD in humans/animal models, termed as contact hyper-sensitivity reaction (CHS). Such studies have demonstrated that the intensity ...
Nguyen Su - - 2013
Abstract Due-date assignment plays an important role in scheduling systems and strongly influences the delivery performance of job shops. Because of the stochastic and dynamic nature of job shops, the development of general due-date assignment models (DDAMs) is complicated. In this study, two genetic programming (GP) methods are proposed to ...
Bhavnani Sanjeev P - - 2013
BACKGROUND: Several meta-analyses of the implantable cardioverter-defibrillator (ICD) clinical trials have demonstrated that while men derived a mortality reduction with prophylactic ICD implantation, women did not. These trials also observed that women receive less appropriate ICD shock therapy compared to men. We aimed to investigate this "gender-paradox" among a heterogeneous ...
Saravanan Subramanian - - 2013
This study investigated the hypothesis that the voluntary feed intake in fish is regulated by diet-induced differences in oxygen use. Four diets were prepared with a similar digestible protein:digestible energy ratio (18 mg/kJ), but which differed in the composition of nonprotein energy source. This replacement of fat (F) by starch ...
Rahman M M - - 2013
A series of Pt catalysts supported on Al2 O3 that was doped with different amounts of CeO2 was developed, characterized, and tested in the aqueous-phase reforming (APR) of glycerol to H2 . Catalyst 3Pt/3CeAl, which bore 3 wt % Pt on a support that contained 3 wt % CeO2 , showed the highest carbon ...
Fricker-Hidalgo H H Laboratoire de Parasitologie-Mycologie, Université Joseph Fourier, Grenoble 1 et Centre Hospitalier Universitaire A. Michallon, Grenoble, France. - - 2013
Classically, Toxoplasma infection is associated with high levels of specific IgM antibody and a rise in specific IgG levels 1 to 3 weeks later. Atypical IgG seroconversion, without IgM detection or with transient IgM levels, has been described during serologic follow-up of seronegative pregnant women and raises difficulties in interpreting ...
Ye Fei - - 2013
Three's a crowd: Tri- and tetrasubstituted allyl allenes can be easily accessed by this Cu(I) -catalyzed three-component coupling reaction of N-tosylhydrazones, terminal alkynes, and allyl halides. The reaction proceeds through a mechanism involving copper carbene migratory insertion.
Lee Soon Bo - - 2013
We report the electrochemical grafting of amine-terminated dendrimers encapsulating nanoparticles onto indium tin oxide (ITO) surfaces.
Zhang Tao - - 2013
We report a novel route to prepare multiresponsive organogels through charge-driven assembly between a block ionomer and a diblock copolymer. The ionic complex aggregates to form spherical cores, which are connected by the middle block of the block ionomer to form gels. The organogels are responsive to acids, amines and ...
Longo Valéria Moraes - - 2013
In this research, an experimental and theoretical study was conducted to design a photo-degradation mechanism of the amino acid tryptophan (Trp) in hair fibers. For the experimental research Caucasian hair fibers were exposed to several different solar radiation simulation periods. Then Trp and its photo-products (N- formylkynurenine and kynurenine) were ...
Diaz Patricia I - - 2013
Solid-organ transplant recipients rely on pharmacological immunosuppression to prevent allograft rejection. The effect of such chronic immunosuppression on the microflora at mucosal surfaces is not known. We evaluated the salivary bacterial microbiome of 20 transplant recipients and 19 non-immunosuppressed controls via 454-pyrosequencing of 16S rRNA gene amplicons. Alpha-diversity and global ...
< 10 11 12 13 14 15 16 17 18 19 20 >