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Moulouel Boualem - - 2013
Hepcidin, the key regulatory hormone of iron homeostasis, and iron carriers such as transferrin receptor1 (TFR1), divalent metal transporter1 (DMT1), and ferroportin (FPN) are expressed in kidney. Whether hepcidin plays an intrinsic role in the regulation of renal iron transport is unknown. Here, we analyzed the renal handling of iron ...
Chebrek Safia - - 2013
Abstract We evaluated the prevalence of primary pulmonary hypertension (PHT) in patients with chronic myeloproliferative neoplasms (MPN) in a large series of 103 patients. In sharp contrast with the literature, we found a prevalence of 5% instead of the surprisingly high previously reported prevalence of 38%. That may reflect a ...
Gao Yuyan - - 2013
The connection between inflammation and colorectal cancer (CRC) has been well recognized, and numerous related molecular mechanisms have been uncovered. To gain further insight, we used BALB/c mice treated with azoxymethane (AOM) and dextran sulfate sodium salt (DSS) to establish a colitis-associated CRC model recapitulating tubulovillous adenoma with high-grade dysplasia ...
Goodwin Meredith Rumon - - 2013
Advances in the surgical approach to thoracic aortic aneurysm repairs have led to the increasing use of one-lung ventilation. Today's practice of cardiothoracic and vascular anesthesia requires a clear understanding of the techniques available for lung separation and the technical skills necessary to employ them. In this article, we discuss ...
Manna Arun K - - 2013
First-principles DFT calculations are carried out to study the changes in structures and electronic properties of two-dimensional single-layer graphene in the presence of non-covalent interactions induced by carbon and boron fullerenes (C60 , C70 , C80 and B80 ). Our study shows that larger carbon fullerene interacts more strongly than ...
Manfrinati Andrea - - 2013
Traditional studies on moral judgement used resolutions of moral dilemmas that were framed in terms of acceptability of the consequentialist action promoting a greater good, thus overlooking the deontological implications (choices cannot be justified by their consequences). Recently, some authors have suggested a parallelism between automatic, unreflective emotional responses and ...
Liu Chao - - 2013
The WEE1 kinase family has been shown to be the major kinase family responsible for phosphorylating Tyr 15 on cyclin-dependent kinase 1 (CDK1). WEE1 homolog 2 (WEE2, also known as WEE1B) was first identified in Xenopus laevis and more recently in humans and mice, and is responsible for phosphorylating the CDK1 inhibitory site ...
Manolova Irena - - 2013
Background: Transforming growth factor-β1 (TGF-β1) exerts broad anti-inflammatory and immunosuppressive effects and plays a key role in self-tolerance. Complete knockout of TGF-β1 in mice results in autoimmunity and multi-organ inflammatory syndrome. The aim of the present study was to determine TGF-β1 serum levels in healthy individuals and in patients with ...
Zhang Qunzhou - - 2013
PURPOSE: Osteonecrosis of the jaw (ONJ) is emerging as one of the important complications in cancer patients treated with antiresorptive agents. This study explored the potential role of IL-17-mediated M1/M2 macrophage alterations in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ). EXPERIMENTAL DESIGN: The expression of IL-17 and M1 ...
Federman Noel - - 2013
Memory consolidation requires gene expression regulation by transcription factors, which eventually may induce chromatin modifications as histone acetylation. This mechanism is regulated by histone acetylases and deacetylases. It is not yet clear whether memory consolidation always recruits histone acetylation or it is only engaged in more persistent memories. To address ...
He Chunnian - - 2013
A facile and scalable in-situ synthesis strategy is developed to fabricate carbon encapsulated Fe3O4 nanoparticles homogeneously embedded in two-dimensional (2D) porous graphitic carbon nanosheets (Fe3O4@C@PGC nanosheets) as a durable high-rate lithium ion battery anode material. With assistance of the surface of NaCl particles, 2D Fe@C@PGC nanosheets can be in-situ synthesized ...
Demondion Pierre - - 2013
OBJECTIVES: The twin aims of this study were to identify the independent predictors of 30-day mortality and to analyse the outcomes of patients with cardiogenic shock (CS) associated with acute myocardial infarction (AMI) and necessitating extracorporeal life support (ECLS). METHODS: The investigation was a single-centre, retrospective study of 77 patients ...
Liu Guixia - - 2013
Give it a tweak: A novel oxidizing directing group was developed for a rhodium(III)-catalyzed CH functionalization of N-phenoxyacetamides with alkynes. A small change in the reaction conditions leads to either ortho-hydroxyphenyl-substituted enamides or cyclization to deliver benzofurans with high selectivity (see scheme; Cp*=C5 Me5 ).
Cheah C Y - - 2013
BackgroundCentral nervous system (CNS) involvement in mantle cell lymphoma (MCL) is uncommon, and the manifestations and natural history are not well described.Patients and methodsWe present the data on 57 patients with MCL who developed CNS involvement, from a database of 1396 consecutively treated patients at 14 institutions.ResultsThe crude incidence of ...
Lawson Marie - - 2013
The synthesis of 2-α-styrylpyridines has been carried out by using the coupling of polyoxygenated N-tosylhydrazones with various 2-halopyridines. We demonstrated that the use of a catalytic amount of PdCl2(MeCN)2 in combination with a bidentate ferrocene DPPF or a monodentate alkyl phosphine (t)Bu2MeP-HBF4 constitutes an efficient protocol for this coupling, providing ...
Xiang Zhao-Bao - - 2013
A new ent-kaurane diterpenoid glycoside (1), named glaucocalyxin G, has been isolated from the n-butanol-soluble fraction of the dried whole plants of Isodon japonica var. glaucocalyx along with two known compounds, namely arjunglucoside (2) and kaempferol-3-O-rutinoside (3). The structures of the isolated compounds were assigned on the basis of their ...
Rechel B - - 2013
The aim of this study was to ascertain the levels and mechanisms of funding public health in Europe.A review of published and unpublished documents and expenditure data was undertaken.Expenditure on public health in Europe is difficult to determine, but data from national health accounts suggest that it differs greatly across ...
Naar-King Sylvie - - 2013
Objective. To describe the asthma medication device skills of high-risk African American adolescents and associations between skills and other components of illness management. Methods. 170 African American adolescents, with at least one hospitalization or two emergency department visits in the last year, demonstrated how they use their asthma quick relief ...
Wagner S - - 2013
Bryophyte biomass and diversity in tropical moist forests decrease dramatically from higher altitudes towards the lowlands. High respiratory carbon losses at high temperatures may partly explain this pattern, if montane species are unable to acclimatise their metabolic rates to lowland temperatures. We transplanted ten bryophyte species from two altitudes (1200 ...
Godier-Furnémont Amandine F G - - 2013
The cardioprotective effects of mesenchymal stem cells (MSCs) include reducing myocyte apoptosis, and this effect can be enhanced by preconditioning and encapsulation in a fibrin scaffold. This study aimed to test the hypothesis that apoptosis imaging can detect the cardioprotective effects of a conditioned MSC patch grafted in a rat ...
Portran D - - 2013
Microtubules (MTs) are dynamic cytoskeletal elements involved in numerous cellular processes. While they are highly rigid polymers with a persistence length of 1-8 mm, they may exhibit curved shape at a scale of few micrometers within cells depending on their biological functions. However, how MT flexural rigidity in cells is ...
Aleman Soo - - 2013
Background. The long-term effect of sustained virological response (SVR) to antiviral therapy on the risk to develop hepatocellular cancer (HCC), liver complications, liver-related deaths and overall death in hepatitis C (HCV) infected patients with liver cirrhosis is not fully known. Methods. These risks were evaluated during long-term follow-up in in 351 patients ...
Niu Lvye - - 2013
A highly effective drug carrier is constructed by coating folic acid-terminated poly(ethylene glycol) (PEG-FA) on single walled carbon nanotubes (SWNTs) in a facile non-covalent method. The anti-cancer drug, doxorubicin (DOX), is further loaded on the surface of SWNTs at a very high loading efficiency, 149.3 ± 4.1%. The drug system (DOX/PEG-FA/SWNTs) exhibits ...
Guo Wenhua - - 2013
A sol-gel cooperative assembly method was demonstrated for the fabrication of inverse opal films with an open surface. In this method, a sol-gel silicate precursor was cooperatively assembled into the interstitial spaces of microspheres at the same time when polystyrene colloidal templates formed in between of two desired substrates. Silica ...
Kojima Taisuke - - 2013
This paper analyzes the use of a dehydrating oil system to determine binodal curves of aqueous two phase system (ATPS). Aqueous droplets containing phase-forming polymers are dehydrated at the interface between two immiscible oils. The droplets shrink due to diffusion of water into the oil phase while constantly maintaining a ...
Neale Alice - - 2013
OBJECTIVES: Perinatal depression and anxiety are prevalent in migrant women. The main aims of this literature review were to understand the psychosocial determinants of depression and anxiety in migrant women antenatally and to explore common clinical presentations. In addition, we aimed to identify barriers and facilitating factors for help-seeking and ...
Chokkanathan Srinivasan - - 2013
Objectives: Using the theory of religious effects (Journal for the Scientific Study of Religion, 42, 17-30 ( 2003 )), the current study examined the relationship among religiosity, psychosocial resources (social support and mastery) and psychological distress. Method: Through face-to-face interviewing, data were collected from 321 randomly selected older adults in ...
Ouweneel Else - - 2013
In order to answer the question whether changes in students' self-efficacy levels co-vary with similar changes in engagement and performance, a field study and an experimental study were conducted among university students. In order to do this, we adopted a subgroup approach. We created "natural" (Study 1) and manipulated (Study ...
Myachykov Andriy - - 2013
TEST is a novel taxonomy of knowledge representations based on three distinct hierarchically organized representational features: Tropism, Embodiment, and Situatedness. Tropic representational features reflect constraints of the physical world on the agent's ability to form, reactivate, and enrich embodied (i.e., resulting from the agent's bodily constraints) conceptual representations embedded in ...
Grolmusz V K - - 2013
The endocannabinoid system contributes to the regulation of appetite, food intake and energy balance. Fatty acid amide hydrolase is responsible for degradating anandamide, a key messenger of the endocannabinoid system. C385A is a common, functionally active genetic polymorphism of the gene encoding fatty acid amide hydrolase and has been associated ...
Eiselt Anne-Kathrin - - 2013
Processing quantity information based on abstract principles is central to intelligent behavior. Neural correlates of quantitative rule selectivity have been identified previously in the prefrontal cortex (PFC). However, whether individual neurons represent rules applied to multiple magnitude types is unknown. We recorded from PFC neurons while monkeys switched between "greater ...
Huang Yang - - 2013
Bending manipulation and direct force measurements of ultrathin boron nitride nanotubes (BNNTs) were performed inside a transmission electron microscope. Our results demonstrate an obvious transition in mechanics of BNNTs when the external diameters of nanotubes are in the range of 10 nm or less. During in situ transmission electron microscopy ...
Ozbay Ismail - - 2013
Baling technology is a preferred method for temporary storage of municipal solid waste (MSW) prior to final disposal. If incineration is intended for final disposal of the bales, the energy content of the baled MSW gains importance. In this study, nine cylindrical bales containing a mix of different waste materials ...
Mallamaci Francesca - - 2013
Long-term visit-to-visit blood pressure (BP) variability predicts a high risk for cardiovascular events in patients with essential hypertension. Whether long-term visit-to-visit BP variability holds the same predictive power in predialysis patients with chronic kidney disease (CKD) is unknown. Here we tested the relationship between long-term visit-to-visit office BP variability and ...
Sun Jie - - 2013
Vasohibin-2 was recently identified as an important pro-angiogenesis factor in solid tumor and intracellular localization of its variants is important for elucidating the downstream mechanism(s) of its effects. Currently there are no reported antibodies affordable for intracellular localization. The aim of this study was to generate and characterize polyclonal antibodies ...
Maurage Pierre - - 2013
A correlation observed between chocolate consumption and the number of Nobel laureates has recently led to the suggestion that consuming more chocolate would increase the number of laureates due to the beneficial effects of cocoa-flavanols on cognitive functioning. We demonstrate that this interpretation is disproved when other flavanol-rich nutriment consumption ...
Romano Joseph - - 2013
Thirty years after its beginning, the HIV/AIDS epidemic is still raging around the world. According to UNAIDS, in 2011 alone 1.7M deaths were attributable to AIDS, and 2.5M people were newly infected by the virus. Despite the success in treating HIV-infected people with potent antiretroviral drugs, preventing HIV infection is ...
Kim Hyungki - - 2013
Direct growth of a single to a few layers of graphene on a germanium nanowire (Gr/Ge NW; see picture) was achieved by a metal-catalyst-free chemical vapor deposition (CVD) process. The Gr/Ge NW was used as anode in a lithium ion battery. This material has a specific capacity of 1059 mA h g(-1) ...
Quinto Francesca - - 2013
(236)U was analyzed in a minerotrophic peat from the last interglacial period and an ombrotrophic peat core representing the last 80 years of atmospheric deposition. The determination of (236)U at levels of 10(7) atoms/g was possible by using ultra-clean laboratory procedures and accelerator mass spectrometry. In the interglacial peat samples ...
Zeidan Fadel - - 2013
Anxiety is the cognitive state related to the inability to control emotional responses to perceived threats. Anxiety is inversely related to brain activity associated with the cognitive regulation of emotions. Mindfulness meditation has been found to regulate anxiety. However, the brain mechanisms involved in meditation-related anxiety relief are largely unknown. ...
Wang Fang - - 2013
Six new glycosides (1-6) have been isolated from the flower buds of Lonicera japonica. Their structures including the absolute configurations were determined by spectroscopic and chemical methods as ( - )-2-hydroxy-5-methoxybenzoic acid 2-O-β-d-(6-O-benzoyl)-glucopyranoside (1), ( - )-4-hydroxy-3,5-dimethoxybenzoic acid 4-O-β-d-(6-O-benzoyl)-glucopyranoside (2), ( - )-(E)-3,5-dimethoxyphenylpropenoic acid 4-O-β-d-(6-O-benzoyl)-glucopyranoside (3), ( - )-(7S,8R)-(4-hydroxyphenylglycerol 9-O-β-d-[6-O-(E)-4-hydroxy-3,5-dimethoxyphenylpropenoyl]-glucopyranoside (4), ( - )-(7S,8R)-(4-hydroxy-3-methoxyphenylglycerol 9-O-β-d-[6-O-(E)-4-hydroxy-3,5-dimethoxyphenylpropenoyl]-glucopyranoside (5), and ( - )-4-hydroxy-3-methoxyphenol β-d-{6-O-[4-O-(7S,8R)-(4-hydroxy-3-methoxyphenylglycerol-8-yl)-3-methoxybenzoyl]}-glucopyranoside (6), ...
Ruljancic Nedjeljka - - 2013
The pathophysiology and treatment of depression involves monoamine neurotransmitters and the magnesium (Mg)-modulated monoaminergic pathway. Serum and platelet Mg concentrations and platelet serotonin concentrations were measured in 79 depressed patients who had attempted suicide, and 101 patients without suicidal behaviour, according to the ICD-10 diagnoses F 33.2 and F32.2, with ...
Dionisio Sasha - - 2013
Seizures are a commonly encountered medical problem. Seizure protocols have been shown to be effective by avoiding inappropriate over- and under treatment, but are not presently utilized in many centres in Australia. We outline a stepwise approach to effective seizure management based on timely investigation and escalating treatment with an ...
Pino Paco - - 2013
Possessing a system that experimentally controls gene expression has been a Holy Grail in molecular malaria research. Several strategies to control gene expression at different levels have been developed; the controlled step can range from transcription initiation to post-translational modification and/or protein degradation. Strategies successfully developed in model organisms and ...
Sánchez-Tena Susana - - 2013
Epidemiological and experimental studies suggest that fiber and phenolic compounds might have a protective effect on the development of colon cancer in humans. Accordingly, we assessed the chemopreventive efficacy and associated mechanisms of action of a lyophilized red grape pomace containing proanthocyanidin-rich dietary fiber (Grape Antioxidant Dietary Fiber, GADF) on ...
Lower Karen M - - 2013
Whereas mutations causing monogenic disorders most frequently lie within the affected gene, sequence variation in complex disorders is more commonly found in non-coding regions. Furthermore, recent genome-wide studies have shown that common DNA sequence variants in non-coding regions are associated with "normal" variation in gene expression resulting in cell-specific and/or ...
Righetti Aurélie A - - 2013
BACKGROUND: Iron deficiency (ID) is a major cause of anemia, along with other nutritional, parasitic, and genetic factors. Accurate biomarkers are needed to estimate the relative contribution of ID to anemia. Soluble transferrin receptor (sTfR) is thought to be unaffected by inflammation. OBJECTIVES: The objectives were to determine the difference ...
Smith David W - - 2013
Arabidopsis thaliana gene At5g06450 encodes a putative DnaQ-like 3'-5' exonuclease domain-containing protein (AtDECP). The DnaQ-like 3'-5' exonuclease domain is often found as a proofreading domain of DNA polymerases. The overall structure of AtDECP adopts an RNase H fold that consists of a mixed β-sheet flanked by α-helices. Interestingly, AtDECP forms ...
Zhang T - - 2013
The present study investigated the genotoxic effects of flumorph in various organs (brain, liver, spleen, kidney and sperm) of mice. The DNA damage, measured as comet tail length (µm), was determined using the alkaline comet assay. The comet assay is a sensitive assay for the detection of genotoxicity caused by ...
Guo Wei - - 2013
The growth arrest DNA damage-inducible gene (GADD45) family, which is composed of GADD45A, GADD45B, and GADD45G, may play similar but not identical roles in tumorigenesis. Genetic changes associated with or responsible for their dysregulation are in general uncommon. The present study was to detect the role of GADD45 gene family ...
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