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Results 601 - 650 of 2349
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Sadlish Heather - - 2013
Translation initiation is an emerging target in oncology and neurobiology indications. Naturally derived and synthetic rocaglamide scaffolds have been used to interrogate this pathway, however, there is uncertainty regarding their precise mechanism(s) of action. We exploited the genetic tractability of yeast to define the primary effect of both a natural ...
Tenzer Stefan - - 2013
RALY is a member of the heterogeneous nuclear ribonucleoproteins, a family of RNA-binding proteins generally involved in many processes of mRNA metabolism. No quantitative proteomic analysis of RALY-containing ribonucleoparticles (RNPs) has been performed so far and the biological role of RALY remains elusive. Here, we present a workflow for the ...
Müller Michael - - 2013
The controversy over the absolute configuration of (+)-erythro-mefloquine, the less psychosis-causing enantiomer of the anti-malarial drug Lariam, has been resolved by Mosher ester crystallization. The configuration determined previously by physical methods is correct, while the configuration determined by three enantioselective syntheses is wrong.
van Tonder J J - - 2013
The organochlorine pesticide, dichlorodiphenyltrichloroethane (DDT), is still used to combat the spread of malaria in several developing countries despite its accumulation and known hepatotoxic effects that have been demonstrated both in vitro and in vivo. N-Acetylcysteine (NAC) is a recognized hepatoprotective agent that has been reported to reduce hepatotoxicity initiated ...
Stokes Alan H - - 2013
When conventional vehicles (eg, methylcellulose and water) impart inadequate physical, chemical, and/or biological properties for proper toxicological assessment of test article formulations, nonconventional vehicles may be considered. Often toxicity data for nonconventional vehicle formulations are limited. Studies were conducted to collect toxicity data from a rodent and a non-rodent species ...
Carere Jason - - 2013
HsaF and HsaG are an aldolase and dehydrogenase from the cholesterol degradation pathway of M. tuberculosis. HsaF could be heterologously expressed and purified as a soluble dimer, but the enzyme was inactive in the absence of HsaG. HsaF catalyzes the aldol cleavage of 4-hydroxy-2-oxoacids to produce pyruvate and an aldehyde. ...
Fischer Michael J M - - 2013
Transient receptor potential vanilloid subtype 1 (TRPV1) is a heat-sensitive ion channel that plays a key role in enhanced pain sensation after inflammation, but directly blocking TRPV1 causes hyperthermia and decreased sensitivity to painful levels of heat in animals and humans. Here we explore an alternative analgesic strategy in which ...
Chang D-H - - 2013
Purpose: Evaluation of complications, patient satisfaction and clinical benefit of port systems with authorization for high pressure injection of contrast agent during CT/MR examinations. Materials and Methods: Ultrasound-guided insertions of central venous port catheters were performed through the lateral subclavian vein at a university teaching hospital. The radiological information system ...
Thanyasiriwat T - - 2013
Starch pasting viscosity is an important quality trait in cassava (Manihot esculenta Crantz) cultivars. The aim here was to identify loci and candidate genes associated with the starch pasting viscosity. Quantitative trait loci (QTL) mapping for seven pasting viscosity parameters was carried out using 100 lines of an F1 mapping ...
Aoki Sho - - 2013
During locomotion, stepping over an obstacle under visual guidance is crucial to continuous safe walking. Studies of the role of the central nervous system in stepping movements have focused on cerebral cortical areas such as the primary motor cortex and posterior parietal cortex. There is speculation that the lateral cerebellum, ...
Lee Tai-Sung - - 2013
We propose a novel model of JAK2 regulation and activation. In the JAK2 dimer, instead of auto-inhibited by its own JH2 domain, the JH1 domain is inhibited by the JH2 domain of the other monomer. Upon ligand binding, the receptor undergoes conformational rotation that is passed to its partner JAK2 ...
Eddy Edward M - - 2013
In this issue of Biology of Reproduction, de Rooij and van Beek describe a computer model that simulates the population dynamics and interactions of SSCs and their descendants in and around the spermatogonial niche.
Petrenko Natalia - - 2013
All cells perceive and respond to environmental stresses through elaborate stress-sensing networks. Yeast cells sense stress through diverse signaling pathways that converge on the transcription factors Msn2 and Msn4, which respond by initiating rapid, idiosyncratic cycles into and out of the nucleus. To understand the role of Msn2/4 nuclear localization ...
Li Mingming - - 2013
Human embryonic stem cells (hESCs) are uniquely endowed with a capacity for both self-renewal and multi-lineage differentiation. The aim of this investigation was to determine if short periods of cyclic mechanical strain enhanced dexamethasone, ascorbic acid and β-glycerophosphate (triple supplement) induced osteogenesis and bone nodule formation by hESCs. Colonies were ...
Hainsworth John D - - 2013
Purpose: To evaluate the feasibility and efficacy of sorafenib and everolimus in renal cell carcinoma (RCC). Methods: Patients with advanced RCC and ≤1 previous targeted therapy were treated. Results: Maximum tolerated doses were sorafenib 200 mg PO BID, everolimus 35 mg PO once weekly. Dose-limiting toxicity was hand-foot syndrome. The response rate ...
Zhang Jingjing - - 2013
Different forms of biomaterials, including microspheres, sponges, hydrogels and nanofibers have been broadly used in cartilage regeneration; however, effects of internal structures of the biomaterials on cells and chondrogenesis remain largely unexplored. We hypothesized that different internal structures of sponges and hydrogels led to phenotypic disparity of the cells and ...
Wang Cong-Jun - - 2013
Abstract Pancreatic cancer is an aggressive malignancy with a five-year mortality of 97-98% due to widespread metastatic disease. A better understanding of the molecular mechanism of pancreatic cancer is beneficial for the development of novel approaches for early detection and monitoring of pancreatic cancer. We aim to comprehensively identify the ...
Ragg Mark - - 2013
OBJECTIVE: This review sought to determine whether quitting smoking behaviour places people with a history of schizophrenia or major depression at risk of worsening symptoms or relapse. METHOD: Literature searches of Embase, MEDLINE, the Cochrane Library and PsycINFO. RESULTS: Six studies involving 735 people diagnosed with schizophrenia, schizoaffective disorder or ...
Rettenmeier Eva - - 2013
When an ynamide meets a gold carbenoid: Highly electrophilic gold carbenoids available from propargylic esters by means of 1,2-acyloxy migration open up new reaction pathways for ynamide gold chemistry. In this way highly functionalized cyclopentadiene derivatives become accessible (see scheme; EWG=electron-withdrawing group).
Vissing Christoffer Rasmus - - 2013
Mitochondrial myopathies commonly present with exercise intolerance typified by breathlessness and fatigue on exercise. In contrast, exercise-induced rhabdomyolysis and myoglobinuria occur rarely. We present a 43-year-old man with a lifelong history of exercise intolerance associated with myalgia and recurrent episodes of exercise-induced myoglobinuria. From early childhood, he had weekly episodes ...
Yang Z - - 2013
Cardiovascular disease (CVD) is one of the most common chronic diseases in China. This aim of this study is to determine the prevalence of CVDs and risk factors in Chinese impaired glucose regulation subjects.We used a multistage, stratified sampling method to select subjects from the general Chinese population aged 20 ...
Beehler Gregory P - - 2013
OBJECTIVE.: Patients with chronic pain have been shown to be more frequent utilizers of primary care, a contributor to increased health care costs. This study aimed to clarify which patient factors predict primary care utilization among veterans with chronic pain. DESIGN.: Data were gathered from the electronic medical records of ...
Martin Kevan A C - - 2013
Neurons in primary visual cortex of many mammals are clustered according to their preference to stimulus parameters such as orientation and spatial frequency. Nevertheless, responses to complex visual stimuli are highly heterogeneous between adjacent neurons. To investigate the relation between these observations, we recorded from pairs of neighboring neurons in ...
Röhrig R - - 2013
Objectives: The aim of this project is to develop a catalogue of competency-based learning objectives "Medical Informatics" for undergraduate medical education (abbreviated NKLM-MI in German). Methods: The development followed a multi-levelannotation andconsensus process. For each learning objective a reason why a physician needs this competence was required. In addition, each ...
Berg Wendie A - - 2013
Purpose:To determine prospectively the prevalence and rate of malignancy of multiple bilateral (MB) circumscribed breast masses detected at screening ultrasonography (US) compared with those of other US-depicted masses.Materials and Methods:This institutional review board-approved, HIPAA-compliant prospective trial included women at elevated risk for breast cancer, who gave written informed consent to ...
Rodriguez Erin M - - 2013
OBJECTIVES: This study examines associations between maternal depressive symptoms and macro- and micro-level aspects of mothers' communication about their children's cancer. METHODS: Mothers reported depressive symptoms after diagnosis or relapse (child mean age = 10.4 years; 53% male). Mother-child dyads (N = 94) were subsequently observed discussing the child's cancer ...
Moulouel Boualem - - 2013
Hepcidin, the key regulatory hormone of iron homeostasis, and iron carriers such as transferrin receptor1 (TFR1), divalent metal transporter1 (DMT1), and ferroportin (FPN) are expressed in kidney. Whether hepcidin plays an intrinsic role in the regulation of renal iron transport is unknown. Here, we analyzed the renal handling of iron ...
Hisamatsu Takeshi - - 2013
The goal of this study was to examine the role of mTORC2 as a therapeutic target in ovarian clear cell carcinoma (CCC), which is regarded as an aggressive, chemoresistant histological subtype. Using tissue microarrays of 98 primary ovarian cancers (52 CCCs and 46 serous adenocarcinomas (SACs)), activation of mTORC2 was ...
Chebrek Safia - - 2013
Abstract We evaluated the prevalence of primary pulmonary hypertension (PHT) in patients with chronic myeloproliferative neoplasms (MPN) in a large series of 103 patients. In sharp contrast with the literature, we found a prevalence of 5% instead of the surprisingly high previously reported prevalence of 38%. That may reflect a ...
Sanz Sílvia - - 2013
Carbohydrate structures play important roles in many biological processes, including cell-adhesion, cell-cell communication and host-pathogen interactions. Sugar nucleotides are activated forms of sugars used by the cell as donors for most glycosylation reactions. Using a liquid chromatography-tandem mass spectrometry-based method we identified and quantified the pools of UDP-glucose, UDP-galactose, UDP-N-acetylglucosamine, ...
Gao Yuyan - - 2013
The connection between inflammation and colorectal cancer (CRC) has been well recognized, and numerous related molecular mechanisms have been uncovered. To gain further insight, we used BALB/c mice treated with azoxymethane (AOM) and dextran sulfate sodium salt (DSS) to establish a colitis-associated CRC model recapitulating tubulovillous adenoma with high-grade dysplasia ...
Goodwin Meredith Rumon - - 2013
Advances in the surgical approach to thoracic aortic aneurysm repairs have led to the increasing use of one-lung ventilation. Today's practice of cardiothoracic and vascular anesthesia requires a clear understanding of the techniques available for lung separation and the technical skills necessary to employ them. In this article, we discuss ...
Kumar Vijay - - 2013
The soluble guanylyl cyclase (sGC) is an important receptor for nitric oxide (NO). Nitric oxide activates sGC several hundred fold to generate cGMP from GTP. Because of sGC's salutary roles in cardiovascular physiology, it has received substantial attention as a drug target. The heme domain of sGC is key to ...
Manna Arun K - - 2013
First-principles DFT calculations are carried out to study the changes in structures and electronic properties of two-dimensional single-layer graphene in the presence of non-covalent interactions induced by carbon and boron fullerenes (C60 , C70 , C80 and B80 ). Our study shows that larger carbon fullerene interacts more strongly than ...
Manfrinati Andrea - - 2013
Traditional studies on moral judgement used resolutions of moral dilemmas that were framed in terms of acceptability of the consequentialist action promoting a greater good, thus overlooking the deontological implications (choices cannot be justified by their consequences). Recently, some authors have suggested a parallelism between automatic, unreflective emotional responses and ...
Liu Chao - - 2013
The WEE1 kinase family has been shown to be the major kinase family responsible for phosphorylating Tyr 15 on cyclin-dependent kinase 1 (CDK1). WEE1 homolog 2 (WEE2, also known as WEE1B) was first identified in Xenopus laevis and more recently in humans and mice, and is responsible for phosphorylating the CDK1 inhibitory site ...
Manolova Irena - - 2013
Background: Transforming growth factor-β1 (TGF-β1) exerts broad anti-inflammatory and immunosuppressive effects and plays a key role in self-tolerance. Complete knockout of TGF-β1 in mice results in autoimmunity and multi-organ inflammatory syndrome. The aim of the present study was to determine TGF-β1 serum levels in healthy individuals and in patients with ...
Zhang Qunzhou - - 2013
PURPOSE: Osteonecrosis of the jaw (ONJ) is emerging as one of the important complications in cancer patients treated with antiresorptive agents. This study explored the potential role of IL-17-mediated M1/M2 macrophage alterations in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ). EXPERIMENTAL DESIGN: The expression of IL-17 and M1 ...
Federman Noel - - 2013
Memory consolidation requires gene expression regulation by transcription factors, which eventually may induce chromatin modifications as histone acetylation. This mechanism is regulated by histone acetylases and deacetylases. It is not yet clear whether memory consolidation always recruits histone acetylation or it is only engaged in more persistent memories. To address ...
He Chunnian - - 2013
A facile and scalable in-situ synthesis strategy is developed to fabricate carbon encapsulated Fe3O4 nanoparticles homogeneously embedded in two-dimensional (2D) porous graphitic carbon nanosheets (Fe3O4@C@PGC nanosheets) as a durable high-rate lithium ion battery anode material. With assistance of the surface of NaCl particles, 2D Fe@C@PGC nanosheets can be in-situ synthesized ...
Lococo Filippo - - 2013
OBJECTIVESThe efficacy of endoscopic ultrasound (EUS) for evaluating mediastinal adenopathy in lung cancer is nowadays proven. However, its accuracy for detection of malignant pleural effusion per se has not been yet investigated. Herein we report our experience with EUS for detecting pleural effusion during the staging procedure of non-small cell ...
Demondion Pierre - - 2013
OBJECTIVES: The twin aims of this study were to identify the independent predictors of 30-day mortality and to analyse the outcomes of patients with cardiogenic shock (CS) associated with acute myocardial infarction (AMI) and necessitating extracorporeal life support (ECLS). METHODS: The investigation was a single-centre, retrospective study of 77 patients ...
Liu Guixia - - 2013
Give it a tweak: A novel oxidizing directing group was developed for a rhodium(III)-catalyzed CH functionalization of N-phenoxyacetamides with alkynes. A small change in the reaction conditions leads to either ortho-hydroxyphenyl-substituted enamides or cyclization to deliver benzofurans with high selectivity (see scheme; Cp*=C5 Me5 ).
Ruano Rodrigo - - 2013
OBJECTIVE: To document perinatal outcomes following the "Solomon technique" in the selective photocoagulation of placental anastomoses for severe twin-twin transfusion syndrome (TTTS). METHODS: Between January 2010 and July 2012, data were collected from 102 consecutive monochorionic twin pregnancies complicated by severe TTTS that underwent fetoscopic laser ablation. We compared outcomes ...
Cheah C Y - - 2013
BackgroundCentral nervous system (CNS) involvement in mantle cell lymphoma (MCL) is uncommon, and the manifestations and natural history are not well described.Patients and methodsWe present the data on 57 patients with MCL who developed CNS involvement, from a database of 1396 consecutively treated patients at 14 institutions.ResultsThe crude incidence of ...
Lawson Marie - - 2013
The synthesis of 2-α-styrylpyridines has been carried out by using the coupling of polyoxygenated N-tosylhydrazones with various 2-halopyridines. We demonstrated that the use of a catalytic amount of PdCl2(MeCN)2 in combination with a bidentate ferrocene DPPF or a monodentate alkyl phosphine (t)Bu2MeP-HBF4 constitutes an efficient protocol for this coupling, providing ...
Xiang Zhao-Bao - - 2013
A new ent-kaurane diterpenoid glycoside (1), named glaucocalyxin G, has been isolated from the n-butanol-soluble fraction of the dried whole plants of Isodon japonica var. glaucocalyx along with two known compounds, namely arjunglucoside (2) and kaempferol-3-O-rutinoside (3). The structures of the isolated compounds were assigned on the basis of their ...
Rechel B - - 2013
The aim of this study was to ascertain the levels and mechanisms of funding public health in Europe.A review of published and unpublished documents and expenditure data was undertaken.Expenditure on public health in Europe is difficult to determine, but data from national health accounts suggest that it differs greatly across ...
Misiukiewicz Krzysztof J - - 2013
OBJECTIVES:: Two cases of adenoid cystic carcinoma (ACC) of the larynx were treated with chemoradiotherapy (CRT) for organ preservation. We reviewed case series and current literature to contrast the potential role of primary CRT as an organ-sparing modality with standard laryngectomy and radiotherapy in patients with laryngeal ACC. METHODS:: Two ...
Naar-King Sylvie - - 2013
Objective. To describe the asthma medication device skills of high-risk African American adolescents and associations between skills and other components of illness management. Methods. 170 African American adolescents, with at least one hospitalization or two emergency department visits in the last year, demonstrated how they use their asthma quick relief ...
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