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Results 601 - 650 of 2348
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Park Kwang-Won KW Institute for Rare Diseases and Department of Orthopaedic Surgery, Korea University Medical Center, Guro Hospital, 80, Guro-Dong, Guro-Gu, Seoul, 152-703, - - 2013
Although Legg-Calvé-Perthes' disease (LCPD) is frequently associated with varying degrees of femoral head deformity and leg length discrepancy (LLD), no factors that predict residual shortening have been clearly identified. We attempted to determine whether (1) the extent of femoral head involvement; (2) varus osteotomy; and (3) patient demographic characteristics are ...
Cooper Miriam M Child and Adolescent Psychiatry Section, Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK, - - 2014
Traits of autistic spectrum disorders (ASD) occur frequently in attention deficit hyperactivity disorder (ADHD), but the significance of their presence in terms of phenotype and underlying neurobiology is not properly understood. This analysis aimed to determine whether higher levels of autistic traits, as measured by the Social Communication Questionnaire (SCQ), ...
Schroeder J J Department of Sports Medicine and Human Movement Science, University of Hamburg, Mollerstr. 10, 20148, Hamburg, Germany, - - 2013
Spinal form in the sagittal plane and asymmetries of spinal alignment in the frontal plane were identified earlier to be associated with low back pain. This study was aiming at investigating whether age was influencing the significance of these findings. Spinal alignment of 155 older and 58 younger low back ...
Wegienka Ganesa G Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, - - 2013
Uterine leiomyomata are the most common reproductive tumor in women, and their cause is not known. Plasma samples from 155 women (74 with and 81 without ultrasound-confirmed leiomyoma) from a new study of leiomyoma risk factors in the Detroit, Michigan area, were examined for any cross-sectional associations between commonly examined ...
Williams Richard V RV University of Utah, Salt Lake City, - - 2013
Echocardiographic image quality in Fontan survivors may be limited by a variety of factors. We sought to describe echocardiographic quality and factors associated with study quality in subjects participating in the Pediatric Heart Network Fontan Cross-Sectional Study. Echocardiograms were obtained at 7 clinical sites using a standard protocol. Quality grading ...
Keck Thomas M TM Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, Baltimore, MD 21224, - - 2013
The metabotropic glutamate receptor subtype 5 (mGluR5) has been reported to be critically involved in drug reward and addiction. Because the mGluR5 negative allosteric modulators (NAMs) 2-methyl-6-(phenylethynyl)pyridine (MPEP) and 3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine (MTEP) significantly inhibit addictivelike behaviors of cocaine and other drugs of abuse in experimental animals, it has been suggested that ...
Cheng Jie J Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, MD , USA - - 2013
1. Cytochrome P450 2D6 (CYP2D6) is a pivotal enzyme responsible for a major drug oxidation polymorphism in human populations. Distribution of CYP2D6 in brain and its role in serotonin metabolism suggest that CYP2D6 may have a function in the central nervous system. 2. To establish an efficient and accurate platform ...
Borah Bijan J BJ College of Medicine and Division of Health Care Policy and Research, Mayo Clinic, Rochester, Minnesota 55905, USA. - - 2013
The quantile regression (QR) framework provides a pragmatic approach in understanding the differential impacts of covariates along the distribution of an outcome. However, the QR framework that has pervaded the applied economics literature is based on the conditional quantile regression method. It is used to assess the impact of a ...
Van Horn Marion R - - 2013
The rostral superior colliculus (rSC) encodes position errors for multiple types of eye movements, including microsaccades, small saccades, smooth pursuit, and fixation. Here we address whether the rSC contributes to the development of neural signals that are suitable for controlling vergence eye movements. We use both single-unit recording and microstimulation ...
Smith Erlyn C - - 2013
IMPORTANCE Breast cancer in women between the ages of 15 and 39 years (adolescents and young adults [AYAs]) constitutes 5% to 6% of all breast cancer cases in the United States. Breast cancer in AYA women has a worse prognosis than in older women. Five-year survival rates are lowest for ...
Ray Debleena - - 2013
The activation of B cell specific genes, such as CD19 and PAX5 is a hallmark of t(8;21) acute myeloid leukemia (AML) which expresses the translocation product RUNX1/ETO. PAX5 is an important regulator of B lymphoid development and blocks myeloid differentiation when ectopically expressed. To understand the molecular mechanism of PAX5 ...
Barrantes Fidel - - 2013
Chronic opioid usage (COU) for analgesia is common among patients with end-stage renal disease. In order to test whether a prior history of COU negatively affects post-kidney transplant outcomes, we retrospectively examined clinical outcomes in adult kidney transplant patients. Among 1064 adult kidney transplant patients, 452 (42.5%) reported the presence ...
Hajek Roman - - 2013
ABSTRACT Clinical outcomes for patients with multiple myeloma (MM) have improved substantially since the introduction of novel agents, including the proteasome inhibitor bortezomib and the immunomodulatory drugs thalidomide and lenalidomide. However, most patients with MM eventually relapse and prognosis remains poor among patients with relapsed and/or refractory disease. Combination therapy ...
Larrat Sylvie - - 2013
For optimal antiviral therapy, the HCV genotype needs to be determined as it remains a strong predictor of sustained viral response.In this study, we assessed the number of HCV genotyping results that could not be determined using the commercially available line probe assay (Versant Hepatitis C Virus Genotype Assays 2.0 ...
Yu Fenggang - - 2013
OBJECTIVES/HYPOTHESIS: Cancer stem cells have been reported as a new therapeutic target in many cancers, but their existence in nasopharyngeal carcinoma (NPC) is largely unknown. This study was conducted to determine cancer stem-like cells in NPC cell line. STUDY DESIGN: Basic science experimental study. METHODS: Aldehyde dehydrogenase (ALDH) activity, a ...
Boyle Rhianon - - 2013
BACKGROUND: Pelvic floor muscle training (PFMT) is commonly recommended during pregnancy and after birth both for prevention and the treatment of incontinence. OBJECTIVES: Effect of pelvic floor muscle training compared to usual antenatal and postnatal care on incontinence. SEARCH METHODS: Cochrane Incontinence Group Specialized Register; handsearching (searched February 7, 2012); ...
Choi Jong Woo - - 2013
Oropharyngeal defects left after tumor resection are usually reconstructed with radial forearm or anterolateral thigh (ALT) perforator free flaps, but these flaps can be too thin or too thick. In this study, medial sural perforator free flaps with intermediate volumes were used for oropharyngeal reconstruction. Of the 243 patients with ...
Ma Lingli - - 2013
Growth factor receptor-bound protein 10(Grb10)is a Src homology 2 (SH2) domain-containing protein and one of the binding partners for several trans-membrane tyrosine-kinase receptors, including insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1-R). The hippocampus, which is critical for cognitive functions, is one of the main distribution areas of Grb10 ...
Li X-X - - 2013
Pollen presentation theory (PPT) predicts that plant species typically pollinated by frequent and wasteful pollinators ought to be much more parsimonious and only gradually release pollen compared to plant species pollinated by infrequent pollinators that are efficient at delivering the pollen they remove. To test PPT, we compare the pollen ...
Colledge Sarah L - - 2013
An 8-year-old castrated male hound mix was referred to the Purdue University Veterinary Teaching Hospital for severe lameness, pollakiuria, and dyschezia. On presentation, the dog was nonweight bearing on the right rear limb and the right carpus was diffusely swollen. Synovial fluid analysis from the right carpus revealed a population ...
Takahiro Tsujita - - 2013
Using α-amylase inhibition as a separation guide, polyphenolic compounds from almond (Prunus dulcis) seed skin were purified using ultrafiltration, and Sephadex LH-20 and ODS columns. The purified fraction specifically and strongly inhibited α-amylase; the IC50 value was 2.2 μg/mL for pig pancreatic α-amylase. The fraction contained about 62 % of ...
Sadhukhan Tumpa - - 2013
We have investigated the ground state spin of ten pairs of possible photochromic diradical isomers by quantum chemical methods. Dihydrogen pyrenes and dinitrile pyrenes have been chosen as spacers with radical centers attached at (1,7) and (1,8) locations. Oxo-verdazyl has served as radical center, and both C- and N- linkages ...
First Matthew R - - 2013
Vertical migrations of living organisms and settling of particle-attached organisms lead to uneven distributions of biota at different depths in the water column. In ballast tanks, heterogeneity could lead to different population estimates depending on the portion of the discharge sampled. For example, concentrations of organisms exceeding a discharge standard ...
Chen Ruihong - - 2013
Two types of 4f-3d thiostannates with general formula [Hen]2 [Ln(en)4 (CuSn3 S9 )]⋅0.5 en (Ln1; Ln=La, 1; Ce, 2) and [Hen]4 [Ln(en)4 ]2 [Cu6 Sn6 S20 ]⋅3 en (Ln2; Ln=Nd, 3; Gd, 4; Er, 5) were prepared by reactions of Ln2 O3 , Cu, Sn, and S in ethylenediamine (en) under solvothermal ...
Chakraborty Debrup - - 2013
Objective. Ethanolic extract of Gymnema sylvestre (GS) leaves is used as a potent antidiabetic drug in various systems of alternative medicine, including homeopathy. The present study was aimed at examining if GS also had anticancer potentials, and if it had, to elucidate its possible mechanism of action. METHODS: We initially ...
Kim Jiyu - - 2013
CH activation: The ruthenium-catalyzed direct sp(2) CH amidation of arenes by using sulfonyl azides as the amino source is presented. A wide range of substrates were readily amidated including arenes bearing weakly coordinating groups. Synthetic utility of the thus obtained products was demonstrated in the preparation of biologically active heterocycles.
Schwartz J R - - 2013
Dandruff is a chronic, relapsing scalp condition which negatively impacts the quality of life of sufferers. Regular use of anti-fungal shampoos represents a proven therapeutic strategy to improve the most common symptoms of flakes and itch. Two recent approaches for enhancing efficacy of anti-fungal shampoos are maximizing bio-availability of the ...
Zou Liang-Hua - - 2013
An efficient catalytic system for Sonogashira-Hagihara-type reactions displaying ligand acceleration in the copper-catalyzed formation of C(sp(2) )C(sp) bonds is described. The structure of the ligand plays a key role for the coupling efficiency. Various copper sources show excellent catalytic activity, even in sub-mol % quantities. A wide variety of substituents is ...
Allen Vivian - - 2013
Locomotion in living birds (Neornithes) has two remarkable features: feather-assisted flight, and the use of unusually crouched hindlimbs for bipedal support and movement. When and how these defining functional traits evolved remains controversial. However, the advent of computer modelling approaches and the discoveries of exceptionally preserved key specimens now make ...
Wachs Israel E - - 2013
Supported vanadium oxide catalysts contain a vanadium oxide phase deposited on a high surface area oxide support (e.g., Al2O3, SiO2, TiO2, etc.) and have found extensive applications as oxidation catalysts in the chemical, petroleum and environmental industries. This review of supported vanadium oxide catalysts focuses on the fundamental aspects of ...
El Gabaly Farid - - 2013
Nickel is the most commonly used anode for solid-oxide fuel cells (SOFC) due to its fast kinetics and low price. A leading cause of degradation in Ni electrodes is oxidation. Here we use operando ambient-pressure X-ray photoelectron spectroscopy (XPS) to chemically characterize the Ni electrode of a fuel cell anode ...
Aardema Hilde - - 2013
Metabolic conditions characterized by elevated free fatty acid concentrations in blood and follicular fluid are often associated with impaired female fertility. Especially elevated saturated fatty acid levels can be lipotoxic for several somatic cell types. The aim of this study was to determine the impact of elevated free fatty acid ...
Chung Kyung-Sook - - 2013
Previously, we reported that CWJ-082 (6,7-dimethoxy-3-(3-methoxyphenyl)isoquinolin-1-amine) has potent cytotoxic effects on various cancer cells, but the underlying molecular mechanism responsible was not determined. In the present study, CWJ-082 caused cervical cancer cell cycle arrest at the G2/M phase and subsequent caspase-dependent apoptosis. The mitotic arrest caused by CWJ-082 found to ...
Zhang Jing - - 2013
Polyoxometalate (POM) complex (DODA)2 [Mo6 O19 ] with a symmetrical linear structure was prepared conveniently by replacing the tetrabutylammonium (TBA) counterions of Lindquist-type cluster (TBA)2 [Mo6 O19 ] with cationic surfactant dioctadecyldimethylammonium (DODA). A helical self-assembled structure of the complex was formed in dichloromethane/propanol. The dynamically reversible transformation between helical ...
Sadlish Heather - - 2013
Translation initiation is an emerging target in oncology and neurobiology indications. Naturally derived and synthetic rocaglamide scaffolds have been used to interrogate this pathway, however, there is uncertainty regarding their precise mechanism(s) of action. We exploited the genetic tractability of yeast to define the primary effect of both a natural ...
Tenzer Stefan - - 2013
RALY is a member of the heterogeneous nuclear ribonucleoproteins, a family of RNA-binding proteins generally involved in many processes of mRNA metabolism. No quantitative proteomic analysis of RALY-containing ribonucleoparticles (RNPs) has been performed so far and the biological role of RALY remains elusive. Here, we present a workflow for the ...
Müller Michael - - 2013
The controversy over the absolute configuration of (+)-erythro-mefloquine, the less psychosis-causing enantiomer of the anti-malarial drug Lariam, has been resolved by Mosher ester crystallization. The configuration determined previously by physical methods is correct, while the configuration determined by three enantioselective syntheses is wrong.
van Tonder J J - - 2013
The organochlorine pesticide, dichlorodiphenyltrichloroethane (DDT), is still used to combat the spread of malaria in several developing countries despite its accumulation and known hepatotoxic effects that have been demonstrated both in vitro and in vivo. N-Acetylcysteine (NAC) is a recognized hepatoprotective agent that has been reported to reduce hepatotoxicity initiated ...
Stokes Alan H - - 2013
When conventional vehicles (eg, methylcellulose and water) impart inadequate physical, chemical, and/or biological properties for proper toxicological assessment of test article formulations, nonconventional vehicles may be considered. Often toxicity data for nonconventional vehicle formulations are limited. Studies were conducted to collect toxicity data from a rodent and a non-rodent species ...
Carere Jason - - 2013
HsaF and HsaG are an aldolase and dehydrogenase from the cholesterol degradation pathway of M. tuberculosis. HsaF could be heterologously expressed and purified as a soluble dimer, but the enzyme was inactive in the absence of HsaG. HsaF catalyzes the aldol cleavage of 4-hydroxy-2-oxoacids to produce pyruvate and an aldehyde. ...
Fischer Michael J M - - 2013
Transient receptor potential vanilloid subtype 1 (TRPV1) is a heat-sensitive ion channel that plays a key role in enhanced pain sensation after inflammation, but directly blocking TRPV1 causes hyperthermia and decreased sensitivity to painful levels of heat in animals and humans. Here we explore an alternative analgesic strategy in which ...
Chang D-H - - 2013
Purpose: Evaluation of complications, patient satisfaction and clinical benefit of port systems with authorization for high pressure injection of contrast agent during CT/MR examinations. Materials and Methods: Ultrasound-guided insertions of central venous port catheters were performed through the lateral subclavian vein at a university teaching hospital. The radiological information system ...
Thanyasiriwat T - - 2013
Starch pasting viscosity is an important quality trait in cassava (Manihot esculenta Crantz) cultivars. The aim here was to identify loci and candidate genes associated with the starch pasting viscosity. Quantitative trait loci (QTL) mapping for seven pasting viscosity parameters was carried out using 100 lines of an F1 mapping ...
Aoki Sho - - 2013
During locomotion, stepping over an obstacle under visual guidance is crucial to continuous safe walking. Studies of the role of the central nervous system in stepping movements have focused on cerebral cortical areas such as the primary motor cortex and posterior parietal cortex. There is speculation that the lateral cerebellum, ...
Hainsworth John D - - 2013
Purpose: To evaluate the feasibility and efficacy of sorafenib and everolimus in renal cell carcinoma (RCC). Methods: Patients with advanced RCC and ≤1 previous targeted therapy were treated. Results: Maximum tolerated doses were sorafenib 200 mg PO BID, everolimus 35 mg PO once weekly. Dose-limiting toxicity was hand-foot syndrome. The response rate ...
Wang Cong-Jun - - 2013
Abstract Pancreatic cancer is an aggressive malignancy with a five-year mortality of 97-98% due to widespread metastatic disease. A better understanding of the molecular mechanism of pancreatic cancer is beneficial for the development of novel approaches for early detection and monitoring of pancreatic cancer. We aim to comprehensively identify the ...
Ragg Mark - - 2013
OBJECTIVE: This review sought to determine whether quitting smoking behaviour places people with a history of schizophrenia or major depression at risk of worsening symptoms or relapse. METHOD: Literature searches of Embase, MEDLINE, the Cochrane Library and PsycINFO. RESULTS: Six studies involving 735 people diagnosed with schizophrenia, schizoaffective disorder or ...
Rettenmeier Eva - - 2013
When an ynamide meets a gold carbenoid: Highly electrophilic gold carbenoids available from propargylic esters by means of 1,2-acyloxy migration open up new reaction pathways for ynamide gold chemistry. In this way highly functionalized cyclopentadiene derivatives become accessible (see scheme; EWG=electron-withdrawing group).
Vissing Christoffer Rasmus - - 2013
Mitochondrial myopathies commonly present with exercise intolerance typified by breathlessness and fatigue on exercise. In contrast, exercise-induced rhabdomyolysis and myoglobinuria occur rarely. We present a 43-year-old man with a lifelong history of exercise intolerance associated with myalgia and recurrent episodes of exercise-induced myoglobinuria. From early childhood, he had weekly episodes ...
Yang Z - - 2013
Cardiovascular disease (CVD) is one of the most common chronic diseases in China. This aim of this study is to determine the prevalence of CVDs and risk factors in Chinese impaired glucose regulation subjects.We used a multistage, stratified sampling method to select subjects from the general Chinese population aged 20 ...
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