Search Results
Results 551 - 600 of 2349
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Matsumoto Seiji - - 2013
OBJECTIVES: To investigate bladder function in a model of nonbacterial prostatitis (NBP) induced in castrated rats by 17β-estradiol injection. METHODS: Ten-month-old male Wistar rats were divided into two groups, sham and NBP (both N = 8). NBP was induced by castration followed by daily subcutaneous injection of 17β-estradiol for 30 days. On the ...
Cox Richard - - 2013
We describe the QSAR Workbench, a system for the building and analysis of QSAR models. The system is built around the Pipeline Pilot workflow tool and provides access to a variety of model building algorithms for both continuous and categorical data. Traditionally models are built on a one by one ...
Pertici Vincent - - 2013
There have been considerable interests in attempting to reverse the deficit due to a spinal cord injury by restoring neural pathways through the lesion and by rebuilding tissue network. In order to provide an appropriate micro-environment for regrowing axotomized neurons and proliferating and migrating cells, we have implanted small block ...
Roesch Benno - - 2013
BACKGROUND: In clinical practice, α2-adrenoceptor agonists have been adjunctively administered with psychostimulants for the treatment of attention-deficit/hyperactivity disorder (ADHD). Two studies have examined the adjunctive use of guanfacine extended release (GXR, Intuniv(®); Shire Development LLC, Wayne, PA, USA) with psychostimulants in children and adolescents with a suboptimal response to psychostimulant ...
Keating Peter - - 2013
Although the ferret has become an important model species for studying both fundamental and clinical aspects of spatial hearing, previous behavioral work has focused on studies of sound localization and spatial release from masking in the free field. This makes it difficult to tease apart the role played by different ...
Rickmann Mareike - - 2013
Relapse occurs frequently after treatment of acute myeloid leukemia (AML) patients with the FMS-like tyrosine kinase 3-internal tandem duplication (ITD) mutation. The availability of immunologic biomarkers to predict patients at high risk could allow clinicians to accelerate alternative treatments such as stem cell transplantation, immunotherapy, or novel drugs. We have ...
Ali Mohammed K - - 2013
Tracking national progress in diabetes care may aid in the evaluation of past efforts and identify residual gaps in care. We analyzed data for adults with self-reported diabetes from the National Health and Nutrition Examination Survey and the Behavioral Risk Factor Surveillance System to examine risk-factor control, preventive practices, and ...
Sen Zhang Wei - - 2013
The effects of alcohol dehydrogenase (ADH) 2 and aldehyde dehydrogenase (ALDH) 2 genotypes on the alcohol-blood pressure association are unclear. We examined the association of ADH2 or ALDH2 genotypes with blood pressure in older Chinese men. Based on the Guangzhou Biobank Cohort Study (GBCS), 4792 men with valid ADH2, ALDH2 ...
Pandey Ram Vinay - - 2013
Estimating differences in gene expression among alleles is of high interest for many areas in biology and medicine. Here, we present a user-friendly software tool, Allim, to estimate allele-specific gene expression. Because mapping bias is a major problem for reliable estimates of allele-specific gene expression using RNA-seq, Allim combines two ...
Varas-Lorenzo Cristina - - 2013
OBJECTIVE: To conduct a systematic review of observational studies on the risk of acute myocardial infarction (AMI) with use of individual nonsteroidal anti-inflammatory drugs (NSAIDs). METHODS: A search of Medline (PubMed) for observational studies published from 1990 to 2011 identified 3829 articles; 31 reported relative risk (RR) of AMI with ...
Hamm Alexander - - 2013
Occlusion of the main arterial route redirects blood flow to the collateral circulation. We previously reported that macrophages genetically modified to express low levels of prolyl hydroxylase domain protein 2 (PHD2) display an arteriogenic phenotype, which promotes the formation of collateral vessels and protects the skeletal muscle from ischaemic necrosis. ...
Rochat Tamsen J - - 2013
Risk of antenatal depression has been shown to be elevated in Southern Africa and can impact maternal and child outcomes, especially in the context of the Human Immunodeficiency Virus (HIV). Brief screening methods may optimize access to care during pregnancy, particularly where resources are scarce. This research evaluated shorter versions ...
Turewicz Michael - - 2013
Contemporary protein microarrays like the ProtoArray® are used for autoimmune antibody screening studies to discover biomarker panels. For ProtoArray data analysis the software Prospector and a default workflow are suggested by the manufacturer. While analyzing a large data set of a discovery study for diagnostic biomarkers of the Parkinson's Disease ...
Tarabichi M - - 2013
Our knowledge of the biology of solid cancer has greatly progressed during the last few years, and many excellent reviews dealing with the various aspects of this biology have appeared. In the present review, we attempt to bring together these subjects in a general systems biology narrative. It starts from ...
Nakabayashi Hideto H Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Tokyo, - - 2013
The insulin receptor (IR) is expressed ubiquitously in various tissues, where insulin exerts various biological effects on the target cells, such as cellular metabolic changes, cell proliferation and differentiation. Therefore, mimicry of insulin signaling would be a promising strategy to realize artificial control of such cellular fates. In this study, ...
Zhang W - - 2013
The Ashkenazi Jewish population has a several-fold higher prevalence of Crohn's disease (CD) compared with non-Jewish European ancestry populations and has a unique genetic history. Haplotype association is critical to CD etiology in this population, most notably at NOD2, in which three causal, uncommon and conditionally independent NOD2 variants reside ...
Cooper Miriam - - 2013
Traits of autistic spectrum disorders (ASD) occur frequently in attention deficit hyperactivity disorder (ADHD), but the significance of their presence in terms of phenotype and underlying neurobiology is not properly understood. This analysis aimed to determine whether higher levels of autistic traits, as measured by the Social Communication Questionnaire (SCQ), ...
Donato Loïc L Département de Chimie, Université de Sherbrooke, 2500 Boul. de l'Université, Sherbrooke, QC, Canada J1K - - 2013
Three new heteroleptic cationic iridium complexes of the form [Ir(C^N)(btl)](+), where btl = 1,1'-benzyl-4,4'-bi-1H-1,2,3-triazolyl and C^N = 2-phenylpyridine (ppyH) (1), 1-benzyl-4-phenyl-1H-1,2,3-triazole (phtl) (2) or 1-benzyl-4-(2,4-difluorophenyl)-1H-1,2,3-triazole (dFphtl) (3), were synthesized and isolated as their hexafluorophosphate (PF6(-)) salts and fully characterized. The single crystal structure of 3 has been solved. Along the ...
Tang W H Wilson WH Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland 44195, - - 2013
Recent studies in animals have shown a mechanistic link between intestinal microbial metabolism of the choline moiety in dietary phosphatidylcholine (lecithin) and coronary artery disease through the production of a proatherosclerotic metabolite, trimethylamine-N-oxide (TMAO). We investigated the relationship among intestinal microbiota-dependent metabolism of dietary phosphatidylcholine, TMAO levels, and adverse cardiovascular ...
Curtis Anne B AB Department of Medicine, University at Buffalo, Buffalo General Medical Center, 100 High St., D2-76, Buffalo, NY 14203, USA. - - 2013
Right ventricular pacing restores an adequate heart rate in patients with atrioventricular block, but high percentages of right ventricular apical pacing may promote left ventricular systolic dysfunction. We evaluated whether biventricular pacing might reduce mortality, morbidity, and adverse left ventricular remodeling in such patients. We enrolled patients who had indications ...
Van Horn Marion R - - 2013
The rostral superior colliculus (rSC) encodes position errors for multiple types of eye movements, including microsaccades, small saccades, smooth pursuit, and fixation. Here we address whether the rSC contributes to the development of neural signals that are suitable for controlling vergence eye movements. We use both single-unit recording and microstimulation ...
Smith Erlyn C - - 2013
IMPORTANCE Breast cancer in women between the ages of 15 and 39 years (adolescents and young adults [AYAs]) constitutes 5% to 6% of all breast cancer cases in the United States. Breast cancer in AYA women has a worse prognosis than in older women. Five-year survival rates are lowest for ...
Ray Debleena - - 2013
The activation of B cell specific genes, such as CD19 and PAX5 is a hallmark of t(8;21) acute myeloid leukemia (AML) which expresses the translocation product RUNX1/ETO. PAX5 is an important regulator of B lymphoid development and blocks myeloid differentiation when ectopically expressed. To understand the molecular mechanism of PAX5 ...
Barrantes Fidel - - 2013
Chronic opioid usage (COU) for analgesia is common among patients with end-stage renal disease. In order to test whether a prior history of COU negatively affects post-kidney transplant outcomes, we retrospectively examined clinical outcomes in adult kidney transplant patients. Among 1064 adult kidney transplant patients, 452 (42.5%) reported the presence ...
Hajek Roman - - 2013
ABSTRACT Clinical outcomes for patients with multiple myeloma (MM) have improved substantially since the introduction of novel agents, including the proteasome inhibitor bortezomib and the immunomodulatory drugs thalidomide and lenalidomide. However, most patients with MM eventually relapse and prognosis remains poor among patients with relapsed and/or refractory disease. Combination therapy ...
Hennen Eva - - 2013
In the developing and adult CNS multipotent neural stem cells reside in distinct niches. Specific carbohydrates and glycoproteins are expressed in these niche microenvironments that are important regulators of stem cell maintenance and differentiation fate. LewisX (LeX), also known as stage specific embryonic antigen-1 (SSEA-1) or CD15, is a defined ...
Larrat Sylvie - - 2013
For optimal antiviral therapy, the HCV genotype needs to be determined as it remains a strong predictor of sustained viral response.In this study, we assessed the number of HCV genotyping results that could not be determined using the commercially available line probe assay (Versant Hepatitis C Virus Genotype Assays 2.0 ...
Wencewicz Timothy Adam - - 2013
Chemical syntheses and biological evaluation of biscatecholate-monohydroxamate mixed ligand sideromycins utilizing the carbacephalosporin β-lactam antibiotic Lorabid® and the fluoroquinolone antibiotic ciprofloxacin are described. The mixed ligand β-lactam sideromycin (1b) had remarkably selective and extremely potent antibacterial activity against the Gram-negative pathogen Acinetobacter baumannii ATCC 17961 (MIC = 0.0078 μM). The ...
Yu Fenggang - - 2013
OBJECTIVES/HYPOTHESIS: Cancer stem cells have been reported as a new therapeutic target in many cancers, but their existence in nasopharyngeal carcinoma (NPC) is largely unknown. This study was conducted to determine cancer stem-like cells in NPC cell line. STUDY DESIGN: Basic science experimental study. METHODS: Aldehyde dehydrogenase (ALDH) activity, a ...
Boyle Rhianon - - 2013
BACKGROUND: Pelvic floor muscle training (PFMT) is commonly recommended during pregnancy and after birth both for prevention and the treatment of incontinence. OBJECTIVES: Effect of pelvic floor muscle training compared to usual antenatal and postnatal care on incontinence. SEARCH METHODS: Cochrane Incontinence Group Specialized Register; handsearching (searched February 7, 2012); ...
Choi Jong Woo - - 2013
Oropharyngeal defects left after tumor resection are usually reconstructed with radial forearm or anterolateral thigh (ALT) perforator free flaps, but these flaps can be too thin or too thick. In this study, medial sural perforator free flaps with intermediate volumes were used for oropharyngeal reconstruction. Of the 243 patients with ...
Ma Lingli - - 2013
Growth factor receptor-bound protein 10(Grb10)is a Src homology 2 (SH2) domain-containing protein and one of the binding partners for several trans-membrane tyrosine-kinase receptors, including insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1-R). The hippocampus, which is critical for cognitive functions, is one of the main distribution areas of Grb10 ...
Li X-X - - 2013
Pollen presentation theory (PPT) predicts that plant species typically pollinated by frequent and wasteful pollinators ought to be much more parsimonious and only gradually release pollen compared to plant species pollinated by infrequent pollinators that are efficient at delivering the pollen they remove. To test PPT, we compare the pollen ...
Colledge Sarah L - - 2013
An 8-year-old castrated male hound mix was referred to the Purdue University Veterinary Teaching Hospital for severe lameness, pollakiuria, and dyschezia. On presentation, the dog was nonweight bearing on the right rear limb and the right carpus was diffusely swollen. Synovial fluid analysis from the right carpus revealed a population ...
Takahiro Tsujita - - 2013
Using α-amylase inhibition as a separation guide, polyphenolic compounds from almond (Prunus dulcis) seed skin were purified using ultrafiltration, and Sephadex LH-20 and ODS columns. The purified fraction specifically and strongly inhibited α-amylase; the IC50 value was 2.2 μg/mL for pig pancreatic α-amylase. The fraction contained about 62 % of ...
Sadhukhan Tumpa - - 2013
We have investigated the ground state spin of ten pairs of possible photochromic diradical isomers by quantum chemical methods. Dihydrogen pyrenes and dinitrile pyrenes have been chosen as spacers with radical centers attached at (1,7) and (1,8) locations. Oxo-verdazyl has served as radical center, and both C- and N- linkages ...
First Matthew R - - 2013
Vertical migrations of living organisms and settling of particle-attached organisms lead to uneven distributions of biota at different depths in the water column. In ballast tanks, heterogeneity could lead to different population estimates depending on the portion of the discharge sampled. For example, concentrations of organisms exceeding a discharge standard ...
Chen Ruihong - - 2013
Two types of 4f-3d thiostannates with general formula [Hen]2 [Ln(en)4 (CuSn3 S9 )]⋅0.5 en (Ln1; Ln=La, 1; Ce, 2) and [Hen]4 [Ln(en)4 ]2 [Cu6 Sn6 S20 ]⋅3 en (Ln2; Ln=Nd, 3; Gd, 4; Er, 5) were prepared by reactions of Ln2 O3 , Cu, Sn, and S in ethylenediamine (en) under solvothermal ...
van der Ham Ineke J M - - 2013
Objective: The aim of this study was to measure the prevalence of navigation problems in patients with mild stroke, using a navigation questionnaire (the Wayfinding Questionnaire; WQ). In addition, the correlations between WQ scores and quality of life measures and neuropsychological test scores were studied. Methods: A sample of 62 ...
Chakraborty Debrup - - 2013
Objective. Ethanolic extract of Gymnema sylvestre (GS) leaves is used as a potent antidiabetic drug in various systems of alternative medicine, including homeopathy. The present study was aimed at examining if GS also had anticancer potentials, and if it had, to elucidate its possible mechanism of action. METHODS: We initially ...
Kim Jiyu - - 2013
CH activation: The ruthenium-catalyzed direct sp(2) CH amidation of arenes by using sulfonyl azides as the amino source is presented. A wide range of substrates were readily amidated including arenes bearing weakly coordinating groups. Synthetic utility of the thus obtained products was demonstrated in the preparation of biologically active heterocycles.
Schwartz J R - - 2013
Dandruff is a chronic, relapsing scalp condition which negatively impacts the quality of life of sufferers. Regular use of anti-fungal shampoos represents a proven therapeutic strategy to improve the most common symptoms of flakes and itch. Two recent approaches for enhancing efficacy of anti-fungal shampoos are maximizing bio-availability of the ...
Zou Liang-Hua - - 2013
An efficient catalytic system for Sonogashira-Hagihara-type reactions displaying ligand acceleration in the copper-catalyzed formation of C(sp(2) )C(sp) bonds is described. The structure of the ligand plays a key role for the coupling efficiency. Various copper sources show excellent catalytic activity, even in sub-mol % quantities. A wide variety of substituents is ...
Doi S - - 2013
Background and study aims: No prospective comparison of endoscopic ultrasonography-guided direct celiac ganglia neurolysis (EUS - CGN) vs. EUS-guided celiac plexus neurolysis (EUS - CPN) has been reported. The aim of the current study was to compare the effectiveness of EUS - CGN and EUS - CPN in providing pain ...
Allen Vivian - - 2013
Locomotion in living birds (Neornithes) has two remarkable features: feather-assisted flight, and the use of unusually crouched hindlimbs for bipedal support and movement. When and how these defining functional traits evolved remains controversial. However, the advent of computer modelling approaches and the discoveries of exceptionally preserved key specimens now make ...
Wachs Israel E - - 2013
Supported vanadium oxide catalysts contain a vanadium oxide phase deposited on a high surface area oxide support (e.g., Al2O3, SiO2, TiO2, etc.) and have found extensive applications as oxidation catalysts in the chemical, petroleum and environmental industries. This review of supported vanadium oxide catalysts focuses on the fundamental aspects of ...
El Gabaly Farid - - 2013
Nickel is the most commonly used anode for solid-oxide fuel cells (SOFC) due to its fast kinetics and low price. A leading cause of degradation in Ni electrodes is oxidation. Here we use operando ambient-pressure X-ray photoelectron spectroscopy (XPS) to chemically characterize the Ni electrode of a fuel cell anode ...
Aardema Hilde - - 2013
Metabolic conditions characterized by elevated free fatty acid concentrations in blood and follicular fluid are often associated with impaired female fertility. Especially elevated saturated fatty acid levels can be lipotoxic for several somatic cell types. The aim of this study was to determine the impact of elevated free fatty acid ...
Tebbs Irene R - - 2013
Eukaryotic cells require IQGAP family multi-domain adapter proteins for cytokinesis, but many questions remain about how IQGAPs contribute to the process. Here we show that fission yeast IQGAP Rng2p is required for both the normal process of contractile ring formation from precursor nodes and an alternative mechanism where rings form ...
Chung Kyung-Sook - - 2013
Previously, we reported that CWJ-082 (6,7-dimethoxy-3-(3-methoxyphenyl)isoquinolin-1-amine) has potent cytotoxic effects on various cancer cells, but the underlying molecular mechanism responsible was not determined. In the present study, CWJ-082 caused cervical cancer cell cycle arrest at the G2/M phase and subsequent caspase-dependent apoptosis. The mitotic arrest caused by CWJ-082 found to ...
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