Search Results
Results 401 - 450 of 2531
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Conner Jill B - - 2013
Background: Asthma remains a serious global health challenge. Poor control of asthma symptoms is due in part to incorrect use of oral inhaler devices that deliver asthma medications, such as poor inhalation technique or use of a metered dose inhaler (MDI) after the recommended number of doses is expelled. Objective: ...
Wong Cheuk-Kit - - 2013
Recurrent ischemic events after an acute coronary syndrome (ACS) are frequent, despite current antiplatelet therapies and revascularization. Warfarin reduces recurrent ischemia but increases bleeding. Warfarin is difficult to administer with the proportion of time achieving therapeutic international normalized ratios varying within and among individuals. The newer oral anticoagulants have predictable ...
Raposo Sara Caliço - - 2013
Although the skin provides a natural physical barrier against particle penetration, there are opportunities to deliver therapeutic agents through this barrier. With rapid developments in materials science, pharmaceutics, and biotechnology, new systems have emerged for topical glucocorticoids (TG) delivery. Despite being a mature class of drugs, TG are still the ...
Wezgowiec Joanna - - 2013
The influence of electroporation on the Photofrin uptake and distribution was evaluated in the breast adenocarcinoma cells (MCF-7) and normal Chinese hamster ovary cells (CHO) lacking voltage-dependent channels in vitro. Photofrin was used at a concentration of 5 and 25 μM. The uptake of Photofrin was assessed using flow cytometry and ...
Gumuskaya B - - 2013
Background:ERG rearrangements and PTEN (phosphatase and tensin homolog deleted on chromosome 10) loss are two of the most common genetic alterations in prostate cancer. However, there is still significant controversy regarding the order of events of these two changes during the carcinogenic process. We used immunohistochemistry (IHC) to determine ERG ...
Gold Daniel R DR Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA. - - 2013
Diagnosis of leptomeningeal leukemia (and more broadly, leptomeningeal metastasis [LM]) is based on:
Savitz J B JB Laureate Institute for Brain Research, Tulsa, OK, - - 2013
In response to queries about whether brain imaging technology has reached the point where it is useful for making a clinical diagnosis and for helping to guide treatment selection, the American Psychiatric Association (APA) has recently written a position paper on the Clinical Application of Brain Imaging in Psychiatry. The ...
Träger Ulrike U Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, - - 2013
Neuroinflammation is now a well-characterised feature of neurodegenerative diseases. Immune dysfunction outside the central nervous system is also increasingly recognised as part of the diseases. Peripheral inflammation has emerged as a modulator of disease progression and neuropathology in several neurodegenerative diseases, making it targetable in new therapeutic approaches. In addition, ...
Oddy Wendy H WH Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia. - - 2013
Poor dietary habits have been implicated in the development of nonalcoholic fatty liver disease (NAFLD); however, little is known about the role of specific dietary patterns in the development of NAFLD. We examined prospective associations between dietary patterns and NAFLD in a population-based cohort of adolescents. Participants in the Western ...
Fink Howard A HA Minneapolis Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA. - - 2013
Optimum management to prevent recurrent kidney stones is uncertain. To evaluate the benefits and harms of interventions to prevent recurrent kidney stones. MEDLINE, Cochrane, and other databases through September 2012 and reference lists of systematic reviews and randomized, controlled trials (RCTs). 28 English-language RCTs that studied treatments to prevent recurrent ...
Mazur Joanna - - 2013
OBJECTIVES: The aim of this study is to determine the impact that raised mother's education and a relative change in family affluence might have on adolescent general self-efficacy (GSE). METHODS: Data on 600 children born in Poland in January 1995 and their families were used. Data from early childhood and ...
Meijer Hil G E - - 2013
At one level of abstraction neural tissue can be regarded as a medium for turning local synaptic activity into output signals that propagate over large distances via axons to generate further synaptic activity that can cause reverberant activity in networks that possess a mixture of excitatory and inhibitory connections. This ...
Takwoingi Yemisi Y Public Health, Epidemiology and Biostatistics, University of Birmingham, Birmingham, United Kingdom. - - 2013
Systematic reviews that "compare" the accuracy of 2 or more tests often include different sets of studies for each test. To investigate the availability of direct comparative studies of test accuracy and to assess whether summary estimates of accuracy differ between meta-analyses of noncomparative and comparative studies. Systematic reviews in ...
Schuster Christopher C Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, Laboratory of Cellular and Molecular Immunobiology of the Skin, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, - - 2013
Antimicrobial peptides and proteins (AMPs) play important roles in skin immune defense due to their capacity to inhibit growth of microbes. During intrauterine life, the skin immune system has to acquire the prerequisites to protect the newborn from infection in the hostile environment after birth, which includes the production of ...
Hedden Trey T Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, CA, USA. - - 2013
We conducted a meta-analysis of relationships between amyloid burden and cognition in cognitively normal, older adult humans. Methods of assessing amyloid burden included were CSF or plasma assays, histopathology, and PET ligands. Cognitive domains examined were episodic memory, executive function, working memory, processing speed, visuospatial function, semantic memory, and global ...
Kaffashian Sara S INSERM, U1018, Centre for Research in Epidemiology and Population Health, Villejuif; Université de Versailles St. Quentin, France. - - 2013
Our aim was to compare 2 Framingham vascular risk scores with a dementia risk score in relation to 10-year cognitive decline in late middle age. Participants were men and women with mean age of 55.6 years at baseline, from the Whitehall II study, a longitudinal British cohort study. We compared ...
Zhang Huabing H Key Laboratory of Endocrinology, Ministry of Health, PekingUnion Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, - - 2013
Systematic data on discontinuation of statins in routine practice of medicine are limited. To investigate the reasons for statin discontinuation and the role of statin-related events (clinical events or symptoms believed to have been caused by statins) in routine care settings. A retrospective cohort study. Practices affiliated with Brigham and ...
Vassos E - - 2013
A large number of candidate gene studies for aggression and violence have been conducted. Successful identification of associations between genetic markers and aggression would contribute to understanding the neurobiology of antisocial behavior and potentially provide useful tools for risk prediction and therapeutic targets for high-risk groups of patients and offenders. ...
Diatchenko Luda L Regional Center for Neurosensory Disorders, Koury Oral Health Sciences Building, University of North Carolina, Chapel Hill, NC 27599-7455, USA. - - 2013
Musculoskeletal pain conditions, such as fibromyalgia and low back pain, tend to coexist in affected individuals and are characterized by a report of pain greater than expected based on the results of a standard physical evaluation. The pathophysiology of these conditions is largely unknown, we lack biological markers for accurate ...
Kullgren Jeffrey T JT Veterans Affairs Center forClinical Management Research, Veterans Affairs Ann Arbor HealthcareSystem, Ann Arbor, MI 48113-0170, USA. - - 2013
Data on the effectiveness of employer-sponsored financial incentives for employee weight loss are limited. To test the effectiveness of 2 financial incentive designs for promoting weight loss among obese employees. Randomized, controlled trial. (ClinicalTrials.gov: NCT01208350) Children's Hospital of Philadelphia. 105 employees with a body mass index between 30 and 40 ...
Iwamoto Naotaka - - 2013
We report the case of a 61-year-old man with supratentorial extraventricular anaplastic ependymoma who presented with repeated intratumoral hemorrhage. The patient was admitted with headache. Computed tomography and magnetic resonance imaging showed an enhancing mass with intratumoral hemorrhage in the right temporal lobe. Gross total resection was performed. The tumor ...
McBride Christie M CM Department of Physiology, Center for Muscle Biology, University of Kentucky, 800 Rose St. MS508, Lexington, KY 40536, - - 2013
KCNH2 encodes the Kv11.1 channel, which conducts the rapidly activating delayed rectifier K+ current (I Kr) in the heart. KCNH2 mutations cause type 2 long QT syndrome (LQT2), which increases the risk for life-threatening ventricular arrhythmias. LQT2 mutations are predicted to prolong the cardiac action potential (AP) by reducing I ...
Cannas Antonino A Centro per i Disordini del Movimento, Dipartimento di Scienze Cardiovascolari e Neurologiche, Sezione Neurologia, Policlinico Universitario, Università di Cagliari, SS 554 Bivio Sestu, 09042 Monserrato, Cagliari, Italy. - - 2013
Based on our previous finding of the p.A382T founder mutation in ALS patients with concomitant parkinsonism in the Sardinian population, we hypothesized that the same variant may underlie Parkinson's disease (PD) and/or other forms of degenerative parkinsonism on this Mediterranean island. We screened a cohort of 611 patients with PD ...
Fink Karin K Centre de Recherche du CHUM (CRCHUM), Montréal, Québec, - - 2013
Airway epithelial cells are key initial innate immune responders in the fight against respiratory viruses, primarily via the secretion of antiviral and proinflammatory cytokines that act in an autocrine/paracrine fashion to trigger the establishment of an antiviral state. It is currently thought that the early antiviral state in airway epithelial ...
Zhang Xi X Department of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI 53706, - - 2013
We discovered a method of applying a forward pulsed bias to recover the degraded quasi-solid-state dye-sensitized solar cells (DSSCs). Up to 30.7% of the power conversion efficiency (η) of a degraded poly(vinylidene fluoride) (PVDF) based DSSC was recovered by a double-pulse. The recovered η remained higher than that before the ...
Pang Xiaosha X Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street BSB 222, Honolulu, HI 96813, - - 2013
HIV infection and methamphetamine (Meth) abuse both may lead to oxidative stress. This study used HIV-1 transgenic (HIV-1Tg) rats to investigate the independent and combined effects of HIV viral protein expression and low dose repeated Meth exposure on the glutathione (GSH)-centered antioxidant system and oxidative stress in the brain. Total ...
Liikanen Ilkka I Cancer Gene Therapy Group, Department of Pathology and Transplantation laboratory, Haartman Institute, University of Helsinki, Helsinki, - - 2013
Oncolytic adenoviruses and certain chemotherapeutics can induce autophagy and immunogenic cancer cell death. We hypothesized that the combination of oncolytic adenovirus with low-dose temozolomide (TMZ) is safe, effective, and capable of inducing antitumor immune responses. Metronomic low-dose cyclophosphamide (CP) was added to selectively reduce regulatory T-cells. Preclinically, combination therapy inhibited ...
Osborn Mark J MJ Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, - - 2013
Recessive dystrophic epidermolysis bullosa (RDEB) is characterized by a functional deficit of type VII collagen protein due to gene defects in the type VII collagen gene (COL7A1). Gene augmentation therapies are promising, but run the risk of insertional mutagenesis. To abrogate this risk, we explored the possibility of using engineered ...
Harnroongroj Thossart T Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Nakhon Pathom, Thailand. - - 2013
Unstable posterior fracture-dislocation of the hip is determined by the wall defect or acetabular fracture index. The unstable hip is a result of inadequate posterior acetabular coverage of the femoral head from the posterior acetabular wall fracture. In order to measure total posterior acetabular coverage of the femoral head and ...
Borges Edson E Jr Instituto Sapientiae - Centro de Estudos e Pesquisa em Reprodução Humana Assistida, Rua Vieira Maciel, 62, São Paulo, SP, 04503-040, Brazil. - - 2013
To compare the results of intracytoplasmic morphologically selected sperm injection (IMSI) between cycles in which the swim-up (SUP) or the density gradient centrifugation (DGC) techniques were used for sperm preparation. We evaluated 70 IMSI cycles performed in women with age ≤ 37 years, undergoing IMSI as result of male factor. ...
Krishnan Tandava - - 2013
We conducted a retrospective review of 11 eyes undergoing eye wall resection between October 1998 and October 2009. The median age of 11 patients was 29 years. Decreased vision (eight) was the most common presenting symptom. Ciliary body medulloepithelioma was the most common clinical diagnosis (six). Medulloepithelioma was the most ...
Hanks Lynae J LJ Department of Nutrition Sciences, University of Alabama at Birmingham, Webb 445, 1720 Second Ave South, Birmingham, AL, 35294-3360, USA, - - 2013
Given that calcium metabolism is influenced by genes and is tightly linked to energy-utilizing pathways, this study evaluated the association of single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) and calcium-sensing receptor (CASR) with resting energy expenditure (REE). In 273 boys and girls, 7-12 years of age, cross-sectional REE ...
Aslibekyan S - - 2013
Methotrexate (MTX) has emerged as first-line therapy for early moderate-to-severe rheumatoid arthritis (RA), but individual variation in treatment response remains unexplained. We tested the associations between 863 known pharmacogenetic variants and MTX response in 471 Treatment of Early Aggressive Rheumatoid Arthritis Trial participants with early RA. Efficacy and toxicity were ...
Dubljanin-Raspopović Emilija E Clinic for Physical Medicine and Rehabilitation, Clinical Center Serbia, Faculty of Medicine, University of Belgrade, Pasterova 2, 11000, Belgrade, Serbia. - - 2013
Hip fractures in the elderly are followed by considerable risk of functional decline and mortality. The purposes of this study were to (1) explore predictive factors of functional level at discharge, (2) evaluate 1-year mortality after hip fracture compared with that of the general population, and (3) evaluate the affect ...
Foster Temitope T Division of Digestive Disease, Emory University, 49 Jesse Hill Jr. Dr. S.E., Druid Hills, Atlanta, GA 30324, USA. - - 2013
Nonalcoholic fatty liver disease (NAFLD) is the number one cause of liver disease in the United States. The prevalence rates in African Americans (AA), while significantly lower than other ethnic groups with similar known risk factors, have been quoted as high as 24 %. We aim to determine if the ...
Brandt Debra S DS The University of Iowa, Institute for Clinical and Translational Science, Iowa City, IA, - - 2013
Next generation sequencing offers benefit of improved health through knowledge, but comes with challenges, such as inevitable incidental findings (IFs). The applicability of recommended criteria for disclosure of individual results when applied to disclosure of IFs is not well known. The purpose of this study was to examine how medical ...
Wang Yin Y Section of General Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109, - - 2013
Glycogen, the largest cytosolic macromolecule, is soluble because of intricate construction generating perfect hydrophilic-surfaced spheres. Little is known about neuronal glycogen function and metabolism, though progress is accruing through the neurodegenerative epilepsy Lafora disease (LD) proteins laforin and malin. Neurons in LD exhibit Lafora bodies (LBs), large accumulations of malconstructed ...
Thraen-Borowski Keith M KM Department of Kinesiology, University of Wisconsin-Madison, 2000 Observatory Drive, Madison, WI 53706, - - 2013
The purpose of this study was to examine the relationships between physical activity (PA), social participation, and health-related quality of life (HQOL) in older, long-term colorectal cancer survivors. Male and female colorectal cancer survivors (n = 1,768), aged ≥65 and ≥5 years post-diagnosis, completed surveys on their current PA, social participation, HQOL, health ...
Chen Tzu-an TA Department of Health Promotion Science, School of Public Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, - - 2013
Perceived neighborhood environment (NE) is considered a determinant of daily physical activity (PA). However, evidence concerning differences among types of PA, gender, and age is limited. The study purpose was to clarify the association between NE and walking time (WT) or habitual exercise (HE) across gender, age, and employment status ...
Paholpak Permsak P Department of Spinal Surgery and Medical Engineering, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, - - 2013
Currently degeneration of the intervertebral disc and joint in the degenerative process of the lumbar spine has mainly attracted the attention, however, there are very few literatures focusing on the height of the spinous process. Our objective was to examine in what generation the change in spinous process height occurs ...
Cavell Lianne K LK Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, - - 2013
Controversy exists regarding whether to place a plastic or a metal endobiliary stent in patients with resectable pancreatic cancer who require biliary drainage. Although self-expandable metal stents (SEMS) provide better drainage compared with plastic stents, concerns remain that SEMS may compromise resection and increase postoperative complications. Our objective was to ...
Stefanik Joshua J JJ Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 650 Albany Street, Suite 200, Boston, MA 02118, USA. - - 2013
Patellofemoral joint (PFJ) malalignment (lateral patella displacement and tilt) has been proposed as a cause of patellofemoral pain. Patella height and/or the morphologic features of the femoral trochlea may predispose one to patella malalignment. The purposes of our study were to assess the associations among patella height, morphologic features of ...
Wu Xuejian - - 2013
We present a frequency-sweeping heterodyne interferometer to measure an absolute distance based on a frequency-tunable diode laser calibrated by an optical frequency comb (OFC) and an interferometric phase measurement system. The laser frequency-sweeping process is calibrated by the OFC within a range of 200 GHz and an accuracy of 1.3 kHz, which ...
Ogimoto Akiyoshi - - 2013
Calcium channel blockers (CCBs) are widely used to treat hypertension and generally act on L-type calcium channels. Recent studies have reported that some CCBs can also block channels belonging to other subtypes, such as N-type and T type channels. N-type calcium channels are present at sympathetic nerve terminals. T-type calcium ...
Gilbert Mark R - - 2013
Interview by Rona Williamson, Commissioning Editor Mark R Gilbert studied medicine at the Johns Hopkins School of Medicine in Baltimore (MD, USA). He completed residency training in internal medicine and neurology at the Johns Hopkins Hospital, then was named the first Keck Foundation Fellow in Neuro-Oncology at Johns Hopkins. After ...
Billow Richard M - - 2013
Abstract Inveiglement is a mode of interpersonal influence and control that has particular relevance to group, organizational, and political life. In inveiglement, a person or group is diverted from knowing, believing, or thinking about an idea or a perception that exists mentally, or that could be generated. In the former ...
Clivati C - - 2013
We describe a fiber-optic gyroscope based on the Sagnac effect, realized on a multiplexed telecom fiber network. Our loop encloses an area of 20  km<sup>2</sup> and coexists with Internet data traffic. This Sagnac interferometer is capable of detecting signals that are larger than 10<sup>-8</sup>  (rad/s)/Hz, thus approaching ring laser gyroscopes without using ...
Backus Deborah - - 2013
To examine the association between inpatient and postdischarge rehabilitation services and function, life satisfaction, and community participation 1 year after spinal cord injury (SCI). Prospective, observational. Six rehabilitation facilities. Patients with SCI (N=1376). None. Satisfaction with Life Scale (SWLS), Craig Handicap Assessment and Reporting Technique (CHART), motor FIM (mFIM), and ...
Qian Qun - - 2013
Cross-coupling of alkyl halides with alkenes leading to Heck-type and addition products is summarized. The development of Heck reaction with aliphatic halides although has made significant progress in the past decade and particularly recently, it was much less explored in comparison with the aryl halides. The use of Ni- and ...
Kazama Kyosuke - - 2013
Omentin is a recently identified adipocytokine, and we previously demonstrated that omentin played anti-inflammatory roles in vascular endothelial and smooth muscle cells. We also demonstrated that omentin induced vasodilation in rat isolated blood vessels. However, effects of omentin on blood pressure (BP) are not determined. Here, we examined whether intravenously ...
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