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Results 401 - 450 of 2532
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Chen Qiushu - - 2013
We achieved optofluidic protein lasing using genetically encoded fluorescent protein FRET pairs linked by length-tunable peptides. Up to 25-fold reduction in the donor laser emission was observed when the donor and the acceptor were brought to close proximity, as compared to only 17% reduction in the donor emission using the ...
Vanaelst Barbara - - 2013
Chronic stress exposure is associated with diverse negative health outcomes. It has been hypothesised that stress may also negatively affect the body's mineral status. This study investigates the association between chronic stress and long-term mineral concentrations of calcium (Ca), copper (Cu), iron (Fe), magnesium (Mg), phosphorus (P) and zinc (Zn) ...
Koller Michael T - - 2013
In Switzerland, organ procurement is well organized at the national-level but transplant outcomes have not been systematically monitored so far. Therefore, a novel project, the Swiss Transplant Cohort Study (STCS), was established. The STCS is a prospective multicentre study, designed as a dynamic cohort, which enrolls all solid organ recipients ...
Chopra Pradeep - - 2013
Complex Regional Pain Syndrome (CRPS) is a neuropathic pain syndrome, which involves glial activation and central sensitization in the central nervous system. Here, we describe positive outcomes of two CRPS patients, after they were treated with low-dose naltrexone (a glial attenuator), in combination with other CRPS therapies. Prominent CRPS symptoms ...
Liu Tracy W - - 2013
Prostate cancer is the most common cancer among men and the second cause of male cancer-related deaths. There are currently three critical needs in prostate cancer imaging to personalize cancer treatment: 1. accurate intraprostatic imaging for multiple foci and extra-capsular extent; 2. monitoring local and systemic treatment response and predicting ...
Engelberg Klemens - - 2013
Red blood cell invasion by the malaria parasite Plasmodium falciparum relies on a complex protein network that uses low and high affinity receptor-ligand interactions. Signal transduction through the action of specific kinases is a control mechanism for the orchestration of this process. Here we report on the phosphorylation of the ...
Cochet Hélène - - 2013
Variation in methods and measures, resulting in past dispute over the existence of population handedness in nonhuman great apes, has impeded progress into the origins of human right-handedness and how it relates to the human hallmark of language. Pooling evidence from behavioral studies, neuroimaging and neuroanatomy, we evaluate data on ...
Kim Yong-Won - - 2013
A 55-year-old woman collapsed with chest pain and cardiac arrest. Her pulse was restored after 6 minutes of cardiopulmonary resuscitation, but she remained comatose. Brain MRI (figure) revealed bilateral basal ganglia and right hemispheric cortical lesion, which was typical for anoxic brain injury except for the unilateral cortical involvement. Neck ...
DeOrchis Vincent S - - 2013
A 63-year-old man presented with 4 years of orthostatic tremor while standing, resolving after sitting or leaning against a wall. There was marked subjective unsteadiness, but no falls. Surface EMG in arms and legs demonstrated a 14- to 16-Hz synchronous tremor in antagonist muscles (video on the Neurology Web site ...
Mozaffarian Dariush - - 2013
Long-chain ω-3 polyunsaturated fatty acids (ω3-PUFAs), including eicosapentaenoic acid (EPA) (20:5ω-3), docosapentaenoic acid (DPA) (22:5ω-3), and docosahexaenoic acid (DHA) (22:6ω-3), have been shown to reduce cardiovascular risk, but effects on cause-specific and total mortality and potential dose-responses remain controversial. Most observational studies have assessed self-reported dietary intake and most randomized ...
Wojtkiewicz Joanna - - 2013
The present study examines the response of colon-projecting neurons localized in the inferior mesenteric ganglia (IMG) to axotomy in the pig animal model. In all animals (n = 8), a median laparotomy was performed under anesthesia and the retrograde tracer Fast Blue was injected into the descending colon wall. In experimental animals ...
Conner Jill B - - 2013
Background: Asthma remains a serious global health challenge. Poor control of asthma symptoms is due in part to incorrect use of oral inhaler devices that deliver asthma medications, such as poor inhalation technique or use of a metered dose inhaler (MDI) after the recommended number of doses is expelled. Objective: ...
Wong Cheuk-Kit - - 2013
Recurrent ischemic events after an acute coronary syndrome (ACS) are frequent, despite current antiplatelet therapies and revascularization. Warfarin reduces recurrent ischemia but increases bleeding. Warfarin is difficult to administer with the proportion of time achieving therapeutic international normalized ratios varying within and among individuals. The newer oral anticoagulants have predictable ...
Raposo Sara Caliço - - 2013
Although the skin provides a natural physical barrier against particle penetration, there are opportunities to deliver therapeutic agents through this barrier. With rapid developments in materials science, pharmaceutics, and biotechnology, new systems have emerged for topical glucocorticoids (TG) delivery. Despite being a mature class of drugs, TG are still the ...
Wezgowiec Joanna - - 2013
The influence of electroporation on the Photofrin uptake and distribution was evaluated in the breast adenocarcinoma cells (MCF-7) and normal Chinese hamster ovary cells (CHO) lacking voltage-dependent channels in vitro. Photofrin was used at a concentration of 5 and 25 μM. The uptake of Photofrin was assessed using flow cytometry and ...
Gumuskaya B - - 2013
Background:ERG rearrangements and PTEN (phosphatase and tensin homolog deleted on chromosome 10) loss are two of the most common genetic alterations in prostate cancer. However, there is still significant controversy regarding the order of events of these two changes during the carcinogenic process. We used immunohistochemistry (IHC) to determine ERG ...
Gold Daniel R DR Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA. - - 2013
Diagnosis of leptomeningeal leukemia (and more broadly, leptomeningeal metastasis [LM]) is based on:
Savitz J B JB Laureate Institute for Brain Research, Tulsa, OK, - - 2013
In response to queries about whether brain imaging technology has reached the point where it is useful for making a clinical diagnosis and for helping to guide treatment selection, the American Psychiatric Association (APA) has recently written a position paper on the Clinical Application of Brain Imaging in Psychiatry. The ...
Träger Ulrike U Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, - - 2013
Neuroinflammation is now a well-characterised feature of neurodegenerative diseases. Immune dysfunction outside the central nervous system is also increasingly recognised as part of the diseases. Peripheral inflammation has emerged as a modulator of disease progression and neuropathology in several neurodegenerative diseases, making it targetable in new therapeutic approaches. In addition, ...
Oddy Wendy H WH Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia. - - 2013
Poor dietary habits have been implicated in the development of nonalcoholic fatty liver disease (NAFLD); however, little is known about the role of specific dietary patterns in the development of NAFLD. We examined prospective associations between dietary patterns and NAFLD in a population-based cohort of adolescents. Participants in the Western ...
Fink Howard A HA Minneapolis Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA. - - 2013
Optimum management to prevent recurrent kidney stones is uncertain. To evaluate the benefits and harms of interventions to prevent recurrent kidney stones. MEDLINE, Cochrane, and other databases through September 2012 and reference lists of systematic reviews and randomized, controlled trials (RCTs). 28 English-language RCTs that studied treatments to prevent recurrent ...
Mazur Joanna - - 2013
OBJECTIVES: The aim of this study is to determine the impact that raised mother's education and a relative change in family affluence might have on adolescent general self-efficacy (GSE). METHODS: Data on 600 children born in Poland in January 1995 and their families were used. Data from early childhood and ...
Meijer Hil G E - - 2013
At one level of abstraction neural tissue can be regarded as a medium for turning local synaptic activity into output signals that propagate over large distances via axons to generate further synaptic activity that can cause reverberant activity in networks that possess a mixture of excitatory and inhibitory connections. This ...
Takwoingi Yemisi Y Public Health, Epidemiology and Biostatistics, University of Birmingham, Birmingham, United Kingdom. - - 2013
Systematic reviews that "compare" the accuracy of 2 or more tests often include different sets of studies for each test. To investigate the availability of direct comparative studies of test accuracy and to assess whether summary estimates of accuracy differ between meta-analyses of noncomparative and comparative studies. Systematic reviews in ...
Osborn Mark J MJ Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, - - 2013
Recessive dystrophic epidermolysis bullosa (RDEB) is characterized by a functional deficit of type VII collagen protein due to gene defects in the type VII collagen gene (COL7A1). Gene augmentation therapies are promising, but run the risk of insertional mutagenesis. To abrogate this risk, we explored the possibility of using engineered ...
Diatchenko Luda L Regional Center for Neurosensory Disorders, Koury Oral Health Sciences Building, University of North Carolina, Chapel Hill, NC 27599-7455, USA. - - 2013
Musculoskeletal pain conditions, such as fibromyalgia and low back pain, tend to coexist in affected individuals and are characterized by a report of pain greater than expected based on the results of a standard physical evaluation. The pathophysiology of these conditions is largely unknown, we lack biological markers for accurate ...
Schuster Christopher C Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, Laboratory of Cellular and Molecular Immunobiology of the Skin, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, - - 2013
Antimicrobial peptides and proteins (AMPs) play important roles in skin immune defense due to their capacity to inhibit growth of microbes. During intrauterine life, the skin immune system has to acquire the prerequisites to protect the newborn from infection in the hostile environment after birth, which includes the production of ...
Kullgren Jeffrey T JT Veterans Affairs Center forClinical Management Research, Veterans Affairs Ann Arbor HealthcareSystem, Ann Arbor, MI 48113-0170, USA. - - 2013
Data on the effectiveness of employer-sponsored financial incentives for employee weight loss are limited. To test the effectiveness of 2 financial incentive designs for promoting weight loss among obese employees. Randomized, controlled trial. (ClinicalTrials.gov: NCT01208350) Children's Hospital of Philadelphia. 105 employees with a body mass index between 30 and 40 ...
Hedden Trey T Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, CA, USA. - - 2013
We conducted a meta-analysis of relationships between amyloid burden and cognition in cognitively normal, older adult humans. Methods of assessing amyloid burden included were CSF or plasma assays, histopathology, and PET ligands. Cognitive domains examined were episodic memory, executive function, working memory, processing speed, visuospatial function, semantic memory, and global ...
Kaffashian Sara S INSERM, U1018, Centre for Research in Epidemiology and Population Health, Villejuif; Université de Versailles St. Quentin, France. - - 2013
Our aim was to compare 2 Framingham vascular risk scores with a dementia risk score in relation to 10-year cognitive decline in late middle age. Participants were men and women with mean age of 55.6 years at baseline, from the Whitehall II study, a longitudinal British cohort study. We compared ...
Fink Karin K Centre de Recherche du CHUM (CRCHUM), Montréal, Québec, - - 2013
Airway epithelial cells are key initial innate immune responders in the fight against respiratory viruses, primarily via the secretion of antiviral and proinflammatory cytokines that act in an autocrine/paracrine fashion to trigger the establishment of an antiviral state. It is currently thought that the early antiviral state in airway epithelial ...
Zhang Huabing H Key Laboratory of Endocrinology, Ministry of Health, PekingUnion Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, - - 2013
Systematic data on discontinuation of statins in routine practice of medicine are limited. To investigate the reasons for statin discontinuation and the role of statin-related events (clinical events or symptoms believed to have been caused by statins) in routine care settings. A retrospective cohort study. Practices affiliated with Brigham and ...
Foster Temitope T Division of Digestive Disease, Emory University, 49 Jesse Hill Jr. Dr. S.E., Druid Hills, Atlanta, GA 30324, USA. - - 2013
Nonalcoholic fatty liver disease (NAFLD) is the number one cause of liver disease in the United States. The prevalence rates in African Americans (AA), while significantly lower than other ethnic groups with similar known risk factors, have been quoted as high as 24 %. We aim to determine if the ...
Vassos E - - 2013
A large number of candidate gene studies for aggression and violence have been conducted. Successful identification of associations between genetic markers and aggression would contribute to understanding the neurobiology of antisocial behavior and potentially provide useful tools for risk prediction and therapeutic targets for high-risk groups of patients and offenders. ...
Wu Xuejian - - 2013
We present a frequency-sweeping heterodyne interferometer to measure an absolute distance based on a frequency-tunable diode laser calibrated by an optical frequency comb (OFC) and an interferometric phase measurement system. The laser frequency-sweeping process is calibrated by the OFC within a range of 200 GHz and an accuracy of 1.3 kHz, which ...
Ogimoto Akiyoshi - - 2013
Calcium channel blockers (CCBs) are widely used to treat hypertension and generally act on L-type calcium channels. Recent studies have reported that some CCBs can also block channels belonging to other subtypes, such as N-type and T type channels. N-type calcium channels are present at sympathetic nerve terminals. T-type calcium ...
Gilbert Mark R - - 2013
Interview by Rona Williamson, Commissioning Editor Mark R Gilbert studied medicine at the Johns Hopkins School of Medicine in Baltimore (MD, USA). He completed residency training in internal medicine and neurology at the Johns Hopkins Hospital, then was named the first Keck Foundation Fellow in Neuro-Oncology at Johns Hopkins. After ...
Billow Richard M - - 2013
Abstract Inveiglement is a mode of interpersonal influence and control that has particular relevance to group, organizational, and political life. In inveiglement, a person or group is diverted from knowing, believing, or thinking about an idea or a perception that exists mentally, or that could be generated. In the former ...
Clivati C - - 2013
We describe a fiber-optic gyroscope based on the Sagnac effect, realized on a multiplexed telecom fiber network. Our loop encloses an area of 20  km<sup>2</sup> and coexists with Internet data traffic. This Sagnac interferometer is capable of detecting signals that are larger than 10<sup>-8</sup>  (rad/s)/Hz, thus approaching ring laser gyroscopes without using ...
Backus Deborah - - 2013
To examine the association between inpatient and postdischarge rehabilitation services and function, life satisfaction, and community participation 1 year after spinal cord injury (SCI). Prospective, observational. Six rehabilitation facilities. Patients with SCI (N=1376). None. Satisfaction with Life Scale (SWLS), Craig Handicap Assessment and Reporting Technique (CHART), motor FIM (mFIM), and ...
Qian Qun - - 2013
Cross-coupling of alkyl halides with alkenes leading to Heck-type and addition products is summarized. The development of Heck reaction with aliphatic halides although has made significant progress in the past decade and particularly recently, it was much less explored in comparison with the aryl halides. The use of Ni- and ...
Kazama Kyosuke - - 2013
Omentin is a recently identified adipocytokine, and we previously demonstrated that omentin played anti-inflammatory roles in vascular endothelial and smooth muscle cells. We also demonstrated that omentin induced vasodilation in rat isolated blood vessels. However, effects of omentin on blood pressure (BP) are not determined. Here, we examined whether intravenously ...
Nazemi Ali - - 2013
Dendrimers with fully photodegradable backbones were synthesized through the incorporation of photodegradable o-nitrobenzyl esters into a new dendrimer monomer based on 2,2-bis(hydroxymethyl)propionic acid (bis-MPA). Dendrons were synthesized using a divergent approach, and were subsequently coupled to a core molecule in the final step. Photodegradation was performed and it was demonstrated ...
Kozub Mary L - - 2013
Cultural competence requires more than the accumulation of information about cultural groups. An awareness of the nurse's own culture, beliefs, and values is considered by several transcultural nursing theorists to be essential to the development of cultural competence and the provision of quality patient care. Using Transformational Learning Theory, this ...
Hussain Ahmad Fawzi - - 2013
Small interfering RNAs (siRNAs) silence gene expression by triggering the sequence-specific degradation of mRNAs, but the targeted delivery of such reagents remains challenging and a significant obstacle to therapeutic applications. One promising approach is the use of RNA aptamers that bind tumor-associated antigens to achieve the delivery of siRNAs to ...
Arguello Henry - - 2013
The coded aperture snapshot spectral imager (CASSI) senses the spatial and spectral information of a scene using a set of K random projections of the scene onto focal plane array measurements. The reconstruction of the underlying three-dimensional (3D) scene is then obtained by ℓ<sub>1</sub> norm-based inverse optimization algorithms such as ...
Yin Lu - - 2013
ABSTRACT. Lung injury caused by influenza virus infection is widespread. Understanding lung damage and repair progression post infection requires quantitative spatiotemporal information on various cell types mapping into the tissue structure. Based on high content images acquired from an automatic slide scanner, we have developed algorithms to quantify cell infiltration ...
Lee Chuan-En - - 2013
Bistable hybrid-aligned nematic (HAN) liquid crystal devices (LCDs) with silica nanoparticle-coated polyimide alignment films were investigated. It was observed that the existence of the internal electric field produced from the triboelectrically charged silica nanoparticles layer and impurity ions in the LC reduced the total free energy of the HAN-LCD and ...
Luo Hua - - 2013
We have experimentally studied multiple side-band generation for two-frequency components injected into a tapered amplifier (TA) and demonstrated its effects on atomic laser cooling. A heterodyne frequency-beat measurement and a Fabry-Perot interferometer have been applied to analyze the side-band generation with different experimental parameters, such as frequency difference, injection laser ...
Jung Timothy T K - - 2013
Background and Objectives Although serious complications of otitis media (OM) such as brain abscess are rare, sequelae of OM such as tympanic membrane perforation and atelectatic tympanic membrane are quite common. Inner ear sequelae can cause hearing loss and speech and language problems. The objectives of this article are to ...
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