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Chevalier Xavier - - 2013
New treatment options are needed for osteoarthritis (OA) to slow down the structural progression of the disease; current therapies mostly target pain and function with minimal effectiveness. OA results from an imbalance between catabolic and anabolic factors, and biologic agents either target specific catabolic proinflammatory mediators, such as cytokines, nitric ...
Dunlop Jason A - - 2013
Fossil mesostigmatid mites are extremely rare. Inclusions assignable to the tortoise mites (Mesostigmata, Uropodina) are described here for the first time from Eocene (ca. 44-49 Ma) Baltic amber. This is the oldest record of Uropodina and documents the first unequivocal amber examples potentially assignable to the extant genus Uroobovella Berlese, 1903 ...
Kwok Albert C H - - 2013
INTRODUCTION: Stomal varices can develop in patients with ostomy in the setting of portal hypertension. Bleeding from the stomal varices is uncommon, but the consequences can be disastrous. Haemorrhage control measures that have been described in the literature include pressure dressings, stomal revision, mucocutaneous disconnection, variceal suture ligation and sclerotherapy. ...
Lemaitre Florian - - 2013
This case-report describes a massive voriconazole (VRZ) intoxication in a patient with a poor metabolizer profile, highlighted by low plasma main metabolite concentrations (N-oxide voriconazole), despite an extensive genetic profile for CYP2C19 and CYP2C9. The patient was treated with therapeutic dose of VRZ but developed a neurotoxicity leading to hallucinations ...
Benbow Susan Mary - - 2013
ABSTRACT Background: The provision of mental health care for older people will become increasingly important with rising demand related to global demographic changes. This project aimed to identify changes in work patterns of UK consultant old age psychiatrists between 1993 and 2012. Method: A link to an online questionnaire was ...
Chen Qiushu - - 2013
We achieved optofluidic protein lasing using genetically encoded fluorescent protein FRET pairs linked by length-tunable peptides. Up to 25-fold reduction in the donor laser emission was observed when the donor and the acceptor were brought to close proximity, as compared to only 17% reduction in the donor emission using the ...
Vanaelst Barbara - - 2013
Chronic stress exposure is associated with diverse negative health outcomes. It has been hypothesised that stress may also negatively affect the body's mineral status. This study investigates the association between chronic stress and long-term mineral concentrations of calcium (Ca), copper (Cu), iron (Fe), magnesium (Mg), phosphorus (P) and zinc (Zn) ...
Minamimoto Ryogo - - 2013
OBJECTIVES: Cardiac FDG uptake is known to show a variety of patterns under clinical fasting conditions. We hypothesized that focal FDG uptake in the heart (FUH) represents a sign of cardiac disease risk, especially in coronary artery disease (CAD).The aim of this study was to clarify the relationship between FUH ...
Feldman Ruth - - 2013
Reciprocity - the capacity to engage in social exchange that integrates inputs from multiple partners into a unified social event - is a cornerstone of adaptive social life that is learned within dyad-specific attachments during an early period of neuroplasticity. Yet, very little research traced the expression of children's reciprocity ...
Chen Jiong - - 2013
PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide and is difficult to detect at its early stages when treatment is most effective. Therefore, we performed a comparative proteomic study to identify new biomarkers for the detection of PDAC. METHODS: Serum samples from patients with PDAC, ...
Liu Zhong-Hua - - 2013
Species of the genus Variovorax are often isolated from nitrile or amide-containing organic compound-contaminated soil. However, there have been few biological characterizations of Variovorax and their contaminant-degrading enzymes. Previously, we reported a new soil isolate, Variovorax boronicumulans CGMCC 4969, and its nitrile hydratase that transforms the neonicotinoid insecticide thiacloprid into ...
Han Linlin - - 2013
Loss of DBC2 (deleted in breast cancer 2) gene expression is frequent in breast cancer tissues. This can be explained by homozygous deletions or other mutations in a minority of cases but alternative mechanisms need to be investigated. Here, DBC2 expression was significantly suppressed compared with normal breast tissues in ...
Popov Ivan A - - 2013
The chemical bonding analysis using the adaptive natural density partitioning method of the C4F fluorinated graphene sheet revealed a chemical bonding model explaining its particular stability. We proposed that the stability of the C4F fluorinated graphene is due to the so-called "benzation" of graphene. On the basis of our chemical ...
Araujo Ayslan Jorge Santos de - - 2013
BACKGROUND: Arterial hypertension is a multifactorial chronic condition caused by either congenital or acquired factors. OBJECTIVE: To evaluate the effects of Resistance Training (RT) on arterial pressure, and on vascular reactivity and morphology, of L-NAME-treated hypertensive rats. METHODS: Male Wistar rats (200 - 250 g) were allocated into Sedentary Normotensive ...
Fink Karin K Centre de Recherche du CHUM (CRCHUM), Montréal, Québec, - - 2013
Airway epithelial cells are key initial innate immune responders in the fight against respiratory viruses, primarily via the secretion of antiviral and proinflammatory cytokines that act in an autocrine/paracrine fashion to trigger the establishment of an antiviral state. It is currently thought that the early antiviral state in airway epithelial ...
Borghi Alessandro - - 2013
Cherry angiomas (CAs) are common vascular benign skin tumors, characterized by abnormal angiogenesis, whose etiology is still unclear and poorly studied. We investigated the presence of HHV8 in CAs due to virus ability of inducing neoangiogenesis in endothelial cells. A total of 29 patients were enrolled in a randomized, controlled, ...
Assayag Jonathan - - 2013
PURPOSE: Androgens are known to play an important protective role on colorectal carcinogenesis, and thus the objective of this study was to determine whether androgen deprivation therapy (ADT) is associated with an increased risk of incident colorectal cancer in patients with prostate cancer. METHODS: We conducted a population-based cohort study ...
Arayanarakool Rerngchai - - 2013
The kinetic activity of individual enzyme molecules was determined in aqueous droplets generated in a nano- and microfluidic device. To avoid high background noise, the enzyme and substrate solution was confined into femtoliter carriers, achieving high product concentrations from single-molecule encapsulation. The tiny droplets (ϕ ∼ 2.5-3 μm) generated from ...
Latchamsetty Rakesh - - 2013
Catheter ablation has acquired a prominent role in the management of symptomatic atrial fibrillation (AF). Attempting to accurately assess the benefit of ablation can be quite challenging and is influenced by many variables, including the type of AF, procedural technique, operator experience, and duration and method of follow-up. Equally elusive ...
Theodorou Evangelos C - - 2013
AtoSC two-component system (TCS) upregulates the high-molecular weight poly-(R)-3-hydroxybutyrate (PHB) biosynthesis in recombinant phaCAB (+) Escherichia coli strains, with the Cupriavidus necator phaCAB operon. We report here that AtoSC upregulates also the copolymer P(3HB-co-3HV) biosynthesis in phaCAB (+) E. coli. Acetoacetate-induced AtoSC maximized P(3HB-co-3HV) to 1.27 g/l with a 3HV fraction ...
Song Na - - 2013
Trachurus japonicus is a pelagic fish widely distributed from China, Korea to Japan. To examine the gene flow of T. japonicus between Chinese and Japanese coastal waters, eight populations were collected for the present study. Eighty-seven variable sites defined 168 haplotypes. The populations of T. japonicus showed high haplotype diversity ...
Liu Ying - - 2013
A bacterial strain, designated M26(T), was isolated from a fish gastrointestinal tract, collected from Zhanjiang Port, South China. 16S rRNA gene sequence analysis indicated that strain M26(T) belongs to the subclass α-Proteobacteria, being related to the genus Paracoccus, and sharing highest sequence similarity with Paracoccus alcaliphilus JCM 7364(T) (98.1 %), Paracoccus ...
McAllister Linda J - - 2013
Complexes of molecular iodine with alkoxystilbazoles are liquid crystals with unusually high mesophase stability, predicated on an intermolecular II contact. Attempts to prepare analogous complexes with bromine led to an unexpected electrophilic substitution product.
Oviya M - - 2013
The present investigation entails the immobilisation and characterisation of Escherichia coli MO1-derived carbonic anhydrase (CA) and its influence on the transformation of CO2 to CaCO3. CA was purified from MO1 using a combination of Sephadex G-75 and DEAE cellulose column chromatography, resulting in 4.64-fold purification. The purified CA was immobilised ...
Marcolino Milena Soriano - - 2013
BACKGROUND:The creation of an acute myocardial infarction (AMI) management systems is aimed at optimizing the management of patients from early diagnosis to proper and timely treatment. OBJECTIVE: To assess the implantation of an AMI management system in the municipality of Belo Horizonte, state of Minas Gerais, and its impact on ...
Kobayashi Junjiro - - 2013
Coronary artery disease (CAD) is combined with aortic stenosis (AS) in 40-50 % of patients with typical angina. Recently, transcatheter aortic valve implantation (TAVI) has changed the guideline for AS in patients with high comorbidity. At the same time more than 60 % of isolated CABG has been performed without cardiopulmonary bypass ...
Canpolat Uğur - - 2013
In this study, we aimed to evaluate whether serum total bilirubin was associated with the severity and morphology of coronary atherosclerotic plaques detected by computed tomography angiography (CTA). The study population consisted of 1,115 patients (55.2 % men) who underwent dual-source 64-slice CTA for the assessment of coronary artery disease (CAD). ...
McDonald Andrew M - - 2013
Purpose. To determine if high-risk prostate cancer responds differently to hypofractionation. Material and methods. One hundred and fifty-seven men with NCCN high-risk (T3, PSA > 20, or Gleason ≥ 8) clinically localized prostate cancer treated between 1998 and 2010 met the inclusion criteria for the analysis. Eighty-two were treated with ...
Remenyi Bo - - 2013
In the 21(st) century, rheumatic fever (RF) and rheumatic heart disease (RHD) are neglected diseases of marginalized communities. Globally, RHD remains the most-common cardiovascular disease in young people aged <25 years. Although RF and RHD have been almost eradicated in areas with established economies, migration from low-income to high-income settings ...
Kwon Jeong-Eun - - 2013
The functions of microRNAs (miRNAs) as either oncogenes or tumor suppressors in regulating cancer-related events have been established. We analyzed the alterations in the miRNA expression profile of the glioma cell line U-251 caused by ionizing radiation (IR) by using an miRNA array and identified several miRNAs whose expression was ...
Ye Youngjin - - 2013
This feature article presents recent progress made in the synthesis of functional ordered mesoporous materials and their application as high performance electrodes in dye-sensitized solar cells (DSCs) and quantum dot-sensitized solar cells (QDSCs), fuel cells, and Li-ion batteries. Ordered mesoporous materials have been mainly synthesized using two representative synthetic methods: ...
Mark Quentin J - - 2013
Summary Human height is a heritable trait that is known to be influenced by environmental factors and general standard of living. Individual and population stature is correlated with health, education and economic achievement. Strong sexual selection pressures for stature have been observed in multiple diverse populations, however; there is significant ...
Cavell Lianne K LK Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, - - 2013
Controversy exists regarding whether to place a plastic or a metal endobiliary stent in patients with resectable pancreatic cancer who require biliary drainage. Although self-expandable metal stents (SEMS) provide better drainage compared with plastic stents, concerns remain that SEMS may compromise resection and increase postoperative complications. Our objective was to ...
Ali Akin Mustafa - - 2013
Abstract Aim: We aimed to evaluate the deformability characteristics of RBC and the affecting factors in newborns diagnosed with congenital hypothyroidism (CH) and to compare the outcomes after the L-thyroxin treatment. Patients and Method: Enrolled subjects were divided into two subgroups as "patients" and age matched healthy "controls". First blood ...
Iyer Pallavi - - 2013
Abstract Background: Papillary thyroid cancer (PTC) presents with local and distant metastases frequently in children than adults. However, hypoxemia secondary to pulmonary metastases has not been reported in the literature. Sorafenib is a small molecule multi-kinase inhibitor used in iodine-131 refractive papillary thyroid carcinoma. Patient Findings: An 8-year old boy ...
Sarin Sabina - - 2013
A controversial proposal to collapse sexual disorders of desire and arousal is forthcoming in the Diagnostic and Statistical Manual of Mental Disorders (5th ed.) (DSM-5). Yet, no study has attempted to empirically distinguish these disorders by using explicit criteria to recruit and compare distinct groups of low desire and arousal ...
Wang Chao - - 2013
Single immunoglobulin IL-1-related receptor (SIGIRR), which is also known as Toll/interleukin-1 receptor 8, is a member of the interleukin-1 receptor (IL-1R) family. Different from other typical IL-1R superfamily members, SIGIRR seems to exert negatively modulates in immune responses. Several previous studies demonstrated that SIGIRR influences chronic inflammatory or autoimmune diseases, ...
Schuster Christopher C Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, Laboratory of Cellular and Molecular Immunobiology of the Skin, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, - - 2013
Antimicrobial peptides and proteins (AMPs) play important roles in skin immune defense due to their capacity to inhibit growth of microbes. During intrauterine life, the skin immune system has to acquire the prerequisites to protect the newborn from infection in the hostile environment after birth, which includes the production of ...
Heinzow Hauke Sebastian - - 2013
BACKGROUND: Endoscopic ultrasound (EUS) is considered a gold standard in the initial staging of esophageal cancer. There is an ongoing debate whether EUS is useful for tumor staging after neoadjuvant chemotherapy (NAC). METHODS: Ninety-five patients with esophageal cancer were retrospectively analyzed. In 45 patients, EUS was performed prior to and ...
Oschetzki Dominik - - 2013
Azidoacetylene is a highly explosive substance, which has been synthesized and characterized for the first time quite recently [Banert et al., Angew. Chem., Int. Ed., 2012, 51, 7515]. As outlined in this work, the vibrational spectrum of azidoacetylene is dominated by strong couplings. For that reason, we have studied the ...
Kochenderfer James N - - 2013
Most B-cell malignancies express CD19, and a majority of patients with B-cell malignancies are not cured by current standard therapies. Chimeric antigen receptors (CARs) are fusion proteins consisting of antigen recognition moieties and T-cell activation domains. T cells can be genetically modified to express CARs, and adoptive transfer of anti-CD19 ...
Hall Richard - - 2013
BACKGROUND: Canadian physicians are faced with an increasing frequency of drug shortages. We hypothesized that drug shortages have a clinical impact on anesthesia care in Canada. METHODS: We conducted a self-administered survey of anesthesiologists in Canada using the membership list of the Canadian Anesthesiologists' Society. For survey development, we identified ...
Werdell P Jeremy - - 2013
Ocean color measured from satellites provides daily, global estimates of marine inherent optical properties (IOPs). Semi-analytical algorithms (SAAs) provide one mechanism for inverting the color of the water observed by the satellite into IOPs. While numerous SAAs exist, most are similarly constructed and few are appropriately parameterized for all water ...
Sekiguchi Hiroshi - - 2013
Paracentesis has been considered a relatively safe procedure; however, hemorrhagic complications do occur and can be fatal, especially in the context of coagulopathy. We describe the case of a 47-year-old man with coagulopathy secondary to end-stage liver disease, whose hospital course was complicated by paracentesis-related hemoperitoneum leading to abdominal compartment ...
Kimura Akinori - - 2013
Idiopathic cardiomyopathy (ICM) is defined as the cardiac disease caused by functional abnormality of cardiomyocytes, which can be classified into several clinical phenotypes such as hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) . Familial occurrence is well recognized for ICM, and genetic analyses have revealed that mutations in genes for ...
Christensen Alan J - - 2013
This issue represents the 4th Journal of Consulting and Clinical Psychology special issue on behavioral medicine and clinical health psychology over the past 4 decades. Recent developments in health care policy, as well as in the maturation of the science, make a special issue in this area particularly timely. This ...
Curtis Nicola M - - 2013
Reports an error in "Dissemination and effectiveness of multisystemic treatment in New Zealand: A benchmarking study" by Nicola M. Curtis, Kevin R. Ronan, Naamith Heiblum and Kylie Crellin (Journal of Family Psychology, 2009[Apr], Vol 23[2], 119-129). Errors were noted in Tables 2 and 3 having to do with effect size ...
Somekawa Toshihiro - - 2013
We have developed a laser Raman spectroscopy technique for assessing the working conditions of transformers by measuring dissolved C<sub>2</sub>H<sub>2</sub> gas concentrations present in transformer oils. A frequency doubled Q-switched Nd:YAG laser (532 nm) was used as a laser source, and Raman signals at ∼1972  cm<sup>-1</sup> originating from C<sub>2</sub>H<sub>2</sub> gas dissolved in oil ...
Zanca Jeanne M - - 2013
To describe group therapy utilization in spinal cord injury (SCI) inpatient rehabilitation. Prospective observational study. Six inpatient rehabilitation facilities. Patients (N=1376) receiving initial rehabilitation after traumatic SCI. Not applicable. Time spent in group versus individual therapy for physical therapy (PT), occupational therapy (OT), therapeutic recreation (TR), and psychology (PSY) therapies. ...
De Sanctis Sara - - 2013
OBJECTIVE: To investigate the effect of 1-year treatment with the anti-tumor necrosis factor-α (TNF-α) drug etanercept on lipid profile and oxidative stress in children and adolescents with juvenile idiopathic arthritis (JIA). METHODS: Thirty children with JIA (22 females; mean age 12.3 ± SD 5.7 yrs), all eligible for anti-TNF-α treatment, ...
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