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Results 201 - 250 of 2532
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Buckler Andrew J - - 2013
Quantitative imaging biomarkers are of particular interest in drug development for their potential to accelerate the drug development pipeline. The lack of consensus methods and carefully characterized performance hampers the widespread availability of these quantitative measures. A framework to support collaborative work on quantitative imaging biomarkers would entail advanced statistical ...
Best Sara L - - 2013
Introduction: Digital Light Processing hyperspectral imaging (HsI) produces a highly sensitive, real-time tissue oxygenation map to monitor renal perfusion/oxygenation during partial nephrectomy (PN). Our initial experience with HSI revealed considerable variation in the baseline renal oxygenation and we sought to correlate these differences with post-operative renal function. Methods: Hyperspectral images ...
Han Bin - - 2013
A reliable result obtained by qRT-PCR highly depends on accurate transcript normalization using stably expressed reference genes. However, the transcript levels of traditional reference genes are not always stable. Also, the inaccurate normalization could easily lead to the false conclusions. In this report, by using geNorm and NormFinder algorithms, 12 ...
Nelson Valerie - - 2013
Introduction: Because of the central role of the mammalian target of rapamycin (mTOR) pathway in the control and distribution of signals essential for mRNA translation of mitogenic genes and generation of oncogenic proteins, effective targeting of mTOR remains a major goal in medical oncology. Areas covered: This article summarizes preclinical ...
Iwamoto Naotaka - - 2013
We report the case of a 61-year-old man with supratentorial extraventricular anaplastic ependymoma who presented with repeated intratumoral hemorrhage. The patient was admitted with headache. Computed tomography and magnetic resonance imaging showed an enhancing mass with intratumoral hemorrhage in the right temporal lobe. Gross total resection was performed. The tumor ...
Li Yan - - 2013
A method based on electrogenerated chemiluminescence (ECL) for detection of DNA methylation and assay of the methyltransferase activity is developed, and it is demonstrated that the label-free ECL method is capable of detecting methyltransferase with a detection limit of 3 × 10(-6) U mL(-1), using a supersandwich amplification technique.
Sekkal W - - 2013
Under earth surface conditions, in ocean and natural water, calcium carbonate is ubiquitous, forming anhydrous and hydrous minerals. These hydrous phases are of considerable interest for their role as precursors to stable carbonate minerals. Atomistic simulation techniques have been employed here to perform a comprehensive and quantitative study of the ...
Zhang Xi - - 2013
We discovered a method of applying a forward pulsed bias to recover the degraded quasi-solid-state dye-sensitized solar cells (DSSCs). Up to 30.7% of the power conversion efficiency (η) of a degraded poly(vinylidene fluoride) (PVDF) based DSSC was recovered by a double-pulse. The recovered η remained higher than that before the ...
Francis David O - - 2013
OBJECTIVES:Extraesophageal symptoms are common manifestations of gastroesophageal reflux disease (GERD). Lack of a definitive diagnostic or treatment standards complicate management, which often leads to multiple specialty consultations, procedures, pharmaceuticals and diagnostic tests. The aim of this study was to determine the economic burden associated with extraesophageal reflux (EER).METHODS:Direct costs of ...
Kim Mi Seong - - 2013
Gap junctions (GJs) allow direct intercellular communication, and consist of connexins (Cxs). In the mammalian central nervous system, oligodendrocytes express Cx47, Cx32 and Cx29, whereas astrocytes express Cx43, Cx30 and Cx26. Homotypic Cx47/Cx47 GJs couple oligodendrocytes, and heterotypic Cx47/Cx43 channels are the primary GJs at oligodendrocyte/astrocyte junctions. Interestingly, autosomal recessive ...
Mu Wei J - - 2013
Foxl2 is a member of the winged helix/forkhead family of transcription factors and is known to regulate ovarian aromatase, which plays a crucial role in ovarian differentiation. To address the role of Foxl2 in gonads and brain during gonadal development, we isolated the full-length cDNA of Foxl2 and analyzed its ...
Díaz-Bello Z - - 2013
SUMMARY Trypanosoma cruzi I, a discrete typing unit (DTU) found in human infections in Venezuela and other countries of the northern region of South America and in Central America, has been recently classified into five intra-DTU genotypes (Ia, Ib, Ic, Id, Ie) based on sequence polymorphisms found in the spliced ...
Ha Eun Ju - - 2013
Purpose: To evaluate the diagnostic role of core needle biopsy (CNB) in sonographically suspicious thyroid nodules with initially benign cytologic results through a histologic analysis of CNB specimens. Methods: Between October 2008 and July 2011, 88 patients underwent ultrasound (US)-guided CNB for initially benign cytologic results with suspicious US features ...
Francis Nick A - - 2013
Background: Conflicting data on the diagnostic and prognostic value of auscultation abnormalities may be partly explained by inconsistent use of terminology. Objectives: To describe general practitioners use of chest auscultation abnormality terms for patients presenting with acute cough across Europe, and to explore the influence of geographic location and case ...
Wanick Rodrigo Cunha - - 2013
A comparative proteomic approach was used to assess differentially expressed proteins in marine sponges after 36 h of exposure to cadmium (Cd). After separation performed by 2-D polyacrylamide gel electrophoresis, 46 protein spots indicated differential expression, and 17 of these proteins were identified by electrospray ionization quadrupole time-of-flight mass spectrometry. From ...
McGreevy Cora - - 2013
Background. Pulse wave velocity measured using the Vicorder(®) apparatus is a non-invasive indicator of arterial stiffness. The objective of this study was to assess its repeatability in older patients when used by medical professionals with limited experience of the technique. Methods. Aortic pulse wave velocity (aPWV) was measured using the ...
Nishit Srivastava Nishit - - 2013
The prospect of electrically conducting polymers as active substrates for the development of neuroprosthetic devices paves way to uniquely modulate the properties of cell at the electrode interface. The utility of these substrates for promoting differentiation of embryonic stem cells provides alternative route for regenerative medicine. Here, we have tuned ...
Mabvuure Nigel Tapiwa - - 2013
Background: Medical students value teaching by junior doctors and find it comparable to consultant-led teaching. Although several junior doctor-led teaching programmes have been developed, there is insufficient information in the literature to guide junior doctors planning on developing such programmes. Aim: This article gives junior doctors 12 practical tips on ...
Casadesús Ana Victoria - - 2013
Humans, in contrast to other mammals, do not synthesize N-glycolyl-neuraminic acid (Neu5Gc) due to a deletion in the gene (cmah) encoding the enzyme responsible for this conversion, the cytidine monophospho-N-acetyl-neuraminic acid hydroxylase (CMP-Neu5Ac hydroxylase). The detection of considerable amounts of Neu5Gc-sialoconjugates, in particular gangliosides, in human malignancies makes these antigens ...
O'Brien Julia - - 2013
Variceal bleeding remains a life-threatening condition with a 6-week mortality rate of ∼20%. Prevention of variceal bleeding can be achieved using nonselective β-blockers (NSBBs) or endoscopic band ligation (EBL), with NSBBs as the first-line treatment. EBL should be reserved for cases of intolerance or contraindications to NSBBs. Although NSBBs cannot ...
Liikanen Ilkka - - 2013
Oncolytic adenoviruses and certain chemotherapeutics can induce autophagy and immunogenic cancer cell death. We hypothesized that the combination of oncolytic adenovirus with low-dose temozolomide (TMZ) is safe, effective, and capable of inducing antitumor immune responses. Metronomic low-dose cyclophosphamide (CP) was added to selectively reduce regulatory T-cells. Preclinically, combination therapy inhibited ...
Shi Jiaqi - - 2013
The lethal doses (LD50s) of fluorinated, chlorinated, brominated, and iodinated benzene, phenol, and diphenyl ether in mice were ascertained respectively under the consistent condition. The acute toxicity of four benzenes orders in fluorobenzene (FB) < iodobenzene < chlorobenzene≈bromobenzene, that of four phenols orders in 4-iodophenol≈4-bromophenol < 4-chlorophenol (4-MCP) < 4-fluorophenol (4-MFP), and that of four diphenyl ethers orders ...
Tomoike Fumiaki - - 2013
The degradation of purine nucleoside is the first step of purine nucleoside uptake. This degradation is catalyzed by purine nucleoside phosphorylase, which is categorized into two classes: hexameric purine nucleoside phosphorylase (6PNP) and trimeric purine nucleoside phosphorylase (3PNP). Generally, 6PNP and 3PNP degrade adenosine and guanosine, respectively. However, the substrate ...
Huang Chao - - 2013
Predicting membrane protein type is a meaningful task because this kind of information is very useful to explain the function of membrane proteins. Due to the explosion of new protein sequences discovered, it is highly desired to develop efficient computation tools for quickly and accurately predicting the membrane type for ...
Chang Tzu-Pu - - 2013
A 68-year-old man developed vertigo with a lateral medullary syndrome (figure). Right-beating nystagmus, seen under Frenzel lenses, reversed when a vibrator (60 Hz) was applied on either sternocleidomastoid muscle or either mastoid. When the vibrator was turned off, the nystagmus returned to right-beating (video on the Neurology® Web site at ...
Aslibekyan S - - 2013
Methotrexate (MTX) has emerged as first-line therapy for early moderate-to-severe rheumatoid arthritis (RA), but individual variation in treatment response remains unexplained. We tested the associations between 863 known pharmacogenetic variants and MTX response in 471 Treatment of Early Aggressive Rheumatoid Arthritis Trial participants with early RA. Efficacy and toxicity were ...
Floege Jürgen - - 2013
Treatment options for primary IgA nephropathy (IgAN) and Henoch-Schönlein nephritis are still largely based on opinion or weak evidence. Consequently, the recent KDIGO Clinical Practice Guidelines for Glomerulonephritis have assigned low levels of evidence for almost all recommendations and suggestions related to these two diseases. In this Review, we describe ...
Jian-Ling Sun - - 2013
Summarize the value of the change of different parts in treadmill exercise test (TET) ECG to coronary heart disease (CHD) diagnosis. Four hundred and forty-five cases have been included in this investigation, which stayed in our hospital from January of 2006 to March of 2011 and underwent TET and coronary ...
Thraen-Borowski Keith M - - 2013
PURPOSE: The purpose of this study was to examine the relationships between physical activity (PA), social participation, and health-related quality of life (HQOL) in older, long-term colorectal cancer survivors. METHODS: Male and female colorectal cancer survivors (n = 1,768), aged ≥65 and ≥5 years post-diagnosis, completed surveys on their current PA, social participation, ...
Beran Roy G - - 2013
Braley et al.(1) investigated sleep-disordered breathing in multiple sclerosis (MS) using overnight polysomnography. MS produced increased apnea-hypopnea index (AHI) and central apnea index (CAI). Periodic limb movement in sleep (PLMS) with associated periodic limb movement causing arousal (PLMA) was not addressed by the authors.
Faturi C B - - 2013
In this study, we have aimed at outlining the neural systems underlying the expression of contextual fear to social defeat. First, we have developed an experimental procedure, where defeated animals could express, without the presence of a dominant aggressive male, robust and reliable conditioned fear responses to the context associated ...
Mazloumi Mahyar - - 2013
Three dimensional (3D) vertically aligned carbon nanotube (CNT) patterns were utilized as templates for fabricating a mesoporous hybrid architecture composed of CNTs and various crystalline metal oxide (MO; M = Co, Zn, Mn nanoparticles) by a microwave-assisted chemical approach. Post-synthesis thermal treatment of the CNT/MO patterns culminated in structural reorganization, ...
Rankin I - - 2013
Objective: To review the aetiology, investigation, diagnosis, treatment and clinical outcome of children with recurrent croup. Method: Retrospective case note review of all children with recurrent croup referred to the otolaryngology service at our hospital from November 2002 to March 2011. Results: Ninety children with recurrent croup were identified. Twenty-five ...
Gray Phillip J - - 2013
Although in use for over 40 years, proton beam therapy for prostate cancer has only recently come under public scrutiny, due to its increased cost compared to other forms of treatment. While the last decade has seen a rapid accumulation of evidence to suggest that proton beam therapy is both ...
Wang Chao - - 2013
Single immunoglobulin IL-1-related receptor (SIGIRR), which is also known as Toll/interleukin-1 receptor 8, is a member of the interleukin-1 receptor (IL-1R) family. Different from other typical IL-1R superfamily members, SIGIRR seems to exert negatively modulates in immune responses. Several previous studies demonstrated that SIGIRR influences chronic inflammatory or autoimmune diseases, ...
Heinzow Hauke Sebastian - - 2013
BACKGROUND: Endoscopic ultrasound (EUS) is considered a gold standard in the initial staging of esophageal cancer. There is an ongoing debate whether EUS is useful for tumor staging after neoadjuvant chemotherapy (NAC). METHODS: Ninety-five patients with esophageal cancer were retrospectively analyzed. In 45 patients, EUS was performed prior to and ...
Oschetzki Dominik - - 2013
Azidoacetylene is a highly explosive substance, which has been synthesized and characterized for the first time quite recently [Banert et al., Angew. Chem., Int. Ed., 2012, 51, 7515]. As outlined in this work, the vibrational spectrum of azidoacetylene is dominated by strong couplings. For that reason, we have studied the ...
Kochenderfer James N - - 2013
Most B-cell malignancies express CD19, and a majority of patients with B-cell malignancies are not cured by current standard therapies. Chimeric antigen receptors (CARs) are fusion proteins consisting of antigen recognition moieties and T-cell activation domains. T cells can be genetically modified to express CARs, and adoptive transfer of anti-CD19 ...
Hall Richard - - 2013
BACKGROUND: Canadian physicians are faced with an increasing frequency of drug shortages. We hypothesized that drug shortages have a clinical impact on anesthesia care in Canada. METHODS: We conducted a self-administered survey of anesthesiologists in Canada using the membership list of the Canadian Anesthesiologists' Society. For survey development, we identified ...
Minamimoto Ryogo - - 2013
OBJECTIVES: Cardiac FDG uptake is known to show a variety of patterns under clinical fasting conditions. We hypothesized that focal FDG uptake in the heart (FUH) represents a sign of cardiac disease risk, especially in coronary artery disease (CAD).The aim of this study was to clarify the relationship between FUH ...
Feldman Ruth - - 2013
Reciprocity - the capacity to engage in social exchange that integrates inputs from multiple partners into a unified social event - is a cornerstone of adaptive social life that is learned within dyad-specific attachments during an early period of neuroplasticity. Yet, very little research traced the expression of children's reciprocity ...
Chen Jiong - - 2013
PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide and is difficult to detect at its early stages when treatment is most effective. Therefore, we performed a comparative proteomic study to identify new biomarkers for the detection of PDAC. METHODS: Serum samples from patients with PDAC, ...
Liu Zhong-Hua - - 2013
Species of the genus Variovorax are often isolated from nitrile or amide-containing organic compound-contaminated soil. However, there have been few biological characterizations of Variovorax and their contaminant-degrading enzymes. Previously, we reported a new soil isolate, Variovorax boronicumulans CGMCC 4969, and its nitrile hydratase that transforms the neonicotinoid insecticide thiacloprid into ...
Han Linlin - - 2013
Loss of DBC2 (deleted in breast cancer 2) gene expression is frequent in breast cancer tissues. This can be explained by homozygous deletions or other mutations in a minority of cases but alternative mechanisms need to be investigated. Here, DBC2 expression was significantly suppressed compared with normal breast tissues in ...
Popov Ivan A - - 2013
The chemical bonding analysis using the adaptive natural density partitioning method of the C4F fluorinated graphene sheet revealed a chemical bonding model explaining its particular stability. We proposed that the stability of the C4F fluorinated graphene is due to the so-called "benzation" of graphene. On the basis of our chemical ...
Araujo Ayslan Jorge Santos de - - 2013
BACKGROUND: Arterial hypertension is a multifactorial chronic condition caused by either congenital or acquired factors. OBJECTIVE: To evaluate the effects of Resistance Training (RT) on arterial pressure, and on vascular reactivity and morphology, of L-NAME-treated hypertensive rats. METHODS: Male Wistar rats (200 - 250 g) were allocated into Sedentary Normotensive ...
Goetze Jens Peter - - 2013
Abstract Objective. The gastrin and the gastrin/CCK-B receptor genes are co-expressed in several carcinomas. The primary translational product, progastrin, however, is processed to several peptides of which only those that are α-amidated at their C-terminus are receptor ligands. So far, characterization of the progastrin-derived peptides in gastric cancer has not ...
Concepción Patricia - - 2013
Pt impregnated on a Sn-beta catalyst results in a very promising catalyst for the selective hydrogenation of α,β-unsaturated aldehydes, compared to the PtSn co-impregnated beta catalysts. Framework tin ions in the Sn-beta sample stabilize the nucleation of platinum nanoparticles inside the zeolite channel. These Pt(0)-Sn(4+) sites, which are only observed ...
Mongabadi Somayeh - - 2013
In the current study we investigated the effect of repetitive transcranial magnetic stimulation (rTMS) at different frequencies on chemical kindling in rats. Chemical kindling was induced by injection of pentylenetetrazol (PTZ; 45 mg/kg) at the intervals of 48 h between the injections. In the first experiment, effect of 0.25, 1 and 5 Hz ...
Huang Haidong - - 2013
Several strains of the genus Sphingomonas produce sphingans, extracellular polysaccharides used as thickeners, emulsifiers and gelling agents. The pgmG gene from Sphingomonas sanxanigenens, which encodes a bifunctional protein with phosphoglucomutase and phosphomannomutase activities, was cloned and sequenced. The predicted amino acid sequence of the PgmG protein possessed 460 amino acids ...
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