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Results 201 - 250 of 3564
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Lee S H - - 2013
RUNX3 is silenced by histone modification and hypoxia-inducible factor (HIF)-1α is stabilized under hypoxia, but little is known of cross-talk between RUNX3 and HIF-1α under hypoxia. In the present study, the authors investigated the effect of RUNX3 on HIF-1α stability in gastric cancer cells. RUNX3 overexpression was found to downregulate ...
Chen Liang-Yu - - 2013
To evaluate the risk and protective factors for functional decline of veteran home residents in Taiwan to develop disability prevention programs in long term care settings. A prospective cohort study. Two veteran homes in Taiwan. A total of 1045 residents of veteran homes. None. Minimum data set (MDS), resident assessment protocols ...
Momeni Arash A Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, Palo Alto, CA 94304, USA. - - 2013
Systematic reviews constitute the top of the "level-of-evidence pyramid." Despite their strengths, they have been found to be of varying quality, thus raising concerns about their validity and role in influencing clinical practice. In the present study, a quality analysis of systematic reviews with a focus on hand surgery was ...
Vyas Raj M RM Global Smile Foundation, USA. - - 2013
Many health organizations sponsor overseas surgical outreach initiatives, yet none has published a standardized protocol to prevent and manage unforeseen emergencies. Surgeons, anesthesiologists, nurses, and administrators-working together on a brief overseas humanitarian initiative-benefit from education and training to maximize their collective emergency responsiveness. This article outlines the emergency response protocol ...
Frydman Rene - - 2013
The number of live births from IVM oocytes has been increasing over the past two decades. Data concerning the health of IVM infants are reported by the authors of this Views and Reviews.
Forgetta Vincenzo - - 2013
As part of the DNA Sequencing Research Group of the Association of Biomolecular Resource Facilities, we have tested the reproducibility of the Roche/454 GS-FLX Titanium System at five core facilities. Experience with the Roche/454 system ranged from <10 to >340 sequencing runs performed. All participating sites were supplied with an ...
Junna Mithri R MR Division of Epilepsy, Department of Neurology, Mayo Clinic, Rochester, MN 55905, - - 2013
To investigate the prognostic importance of an identified putative underlying risk factor in patients undergoing surgery for intractable temporal lobe epilepsy (TLE). A retrospective study of 400 consecutive patients who underwent TLE surgery between December 21, 1987, and September 11, 1996, was performed. Demographic characteristics, history of remote symptomatic neurologic ...
Norman Ann-Charlott - - 2013
: The clinical microsystem (CMS) approach is widely used and is perceived as helpful in practice but, we ask the question: "Is its learning potential sufficiently utilized?" : To scrutinize aspects of learning within the CMS framework and to clarify the learning aspects the framework includes and thereby support the ...
Lu D D 1] Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, USA [2] Tongji University School of Life Science and Technology, Shanghai, - - 2014
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a key enzyme in prostaglandin (PG) metabolism. This study provides important evidence for inhibition of hepatocellular carcinoma (HCC) growth by 15-PGDH through the 15-keto-prostaglandin E2 (15-keto-PGE2)/peroxisome proliferator-activated receptor-γ (PPARγ)/p21(WAF1/Cip1) signaling pathway. Forced overexpression of 15-PGDH inhibited HCC cell growth in vitro, whereas knockdown of 15-PGDH enhanced ...
Gu Gui-Shan - - 2013
Objective: To introduce bipolar hemiarthroplasty with a two-step osteotomy technique and observe its clinical result for unstable intertrochanteric fractures in senile patients.Methods: Fifteen consecutive patients with unstable intertrochanteric fractures aged from 81 to 92 years with a mean of 85 years were treated in our hospital from August 2006 to ...
Güneri Pelin - - 2013
/st> Dental care providers may diagnose diseases and conditions that affect a patient's general health. The authors reviewed issues related to breaking bad medical news to dental practice patients and provide guidance to clinicians about how to do so. /st> To help reduce the potentially negative effects associated with emotionally ...
Shah Ami A AA Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. - - 2013
Systemic sclerosis (scleroderma) is unique among the rheumatic diseases because it presents the challenge of managing a chronic multisystem autoimmune disease with a widespread obliterative vasculopathy of small arteries that is associated with varying degrees of tissue fibrosis. The hallmark of scleroderma is clinical heterogeneity with subsets that vary in ...
Rohrer James E - - 2013
: To assess delays in response to patient secure e-mail messages in primary care. : Secure electronic messages are initiated by primary care patients. Timely response is necessary for patient safety and quality. : A database of secure messages. : A random sample of 353 secure electronic messages initiated by ...
Chen Shengnan - - 2013
Abstract Telemedicine has become an increasingly popular option for long-distance/virtual medical care and education, but many telemedicine ventures fail to grow beyond the initial pilot stage. Studying the business models of successful telemedicine ventures can help develop business strategies for upcoming ventures. This article describes business models of eight telemedicine ...
Perfect Michelle M - - 2013
To examine the rates of behavioral and adaptive functioning difficulties among youth who never had sleep disordered breathing (SDB), had remitted SDB, had incident SDB, or had persistent SDB; and to determine if there were increased odds of behavioral difficulties among youth with varying SDB histories relative to those who ...
Dickerson Erin B EB Veterinary Clinical Sciences, University of Minnesota, St Paul, MN ; Masonic Cancer Center, University of Minnesota, Minneapolis, - - 2013
Hemangiosarcoma, a natural model of human angiosarcoma, is an aggressive vascular tumor diagnosed commonly in dogs. The documented expression of several receptor tyrosine kinases (RTKs) by these tumors makes them attractive targets for therapeutic intervention using tyrosine kinase inhibitors (TKIs). However, we possess limited knowledge of the effects of TKIs ...
- - 2013
Researchers have found that the Brief Negotiation Interview (BNI), a tool developed at Yale School of Medicine in New Haven, CT, can curb harmful drinking in patients when the tool is used with these patients in the emergency setting. Further, by using the same motivational interviewing techniques employed in the ...
Nika Heinz H Laboratory for Macromolecular Analysis and Proteomics and Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, - - 2013
A sample preparation method for protein C-terminal peptide isolation has been developed. In this strategy, protein carboxylate glycinamidation was preceded by carboxyamidomethylation and optional α- and ϵ-amine acetylation in a one-pot reaction, followed by tryptic digestion of the modified protein. The digest was adsorbed on ZipTip(C18) pipette tips for sequential ...
Chin Michael S MS Division of Plastic Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA. - - 2013
Ionizing radiation is known to have deleterious chronic effects on skin, including fibrosis and poor wound healing, hypothesized as mediated by ischemia and hypoxia. Past studies have been unable to simultaneously investigate changes in perfusion and oxygenation as separate parameters. Hyperspectral imaging has emerged as a tool with which to ...
Peters Matthew N - - 2013
Various electrocardiographic changes have been reported in the setting of acute neurological events, among them large, upright U waves. In contrast, the occurrence of inverted U waves is strongly suggestive of cardiovascular disease, most commonly hypertension, coronary artery disease, or valvular abnormalities. Presented herein is the case of a 29-year-old ...
Rosenberg Aaron - - 2013
Introduction: The platelet derived growth factor (PDGF) signaling pathway has been implicated in both epithelial and stromal mechanisms of prostate cancer progression and postulated as a target for therapy in bone metastases. Imatinib mesylate is a potent inhibitor of the platelet-derived growth factor receptor (PDGFR) and its activity has been ...
Brilleman Samuel L SL Centre for Academic Primary Care, School of Social and Community Medicine, University of Bristol, Bristol, - - 2013
Comorbidity is increasingly common in primary care. The cost implications for patient care and budgetary management are unclear. To investigate whether caring for patients with specific disease combinations increases or decreases primary care costs compared with treating separate patients with one condition each. Retrospective observational study using data on 86 ...
Sohal Harminder-Singh - - 2013
Simultaneous bilateral fractures of the femoral necks are rare injuries, especially when there is no underlying pathological condition. We report a 20-year-old man who sustained bilateral femoral neck fractures resulting from an accidental electric shock with 440 V direct current. Simultaneous bilateral femoral neck fractures after electrical shock injury without ...
Zianni Michael R - - 2013
There is a need for more cost-effective options to more accurately discriminate among members of the Anopheles gambiae complex, particularly An. gambiae and Anopheles arabiensis. These species are morphologically indistinguishable in the adult stage, have overlapping distributions, but are behaviorally and ecologically different, yet both are efficient vectors of malaria ...
Inoue Akihiro - - 2013
Vertebral artery(VA)dissecting aneurysm(VADA), which presents with headache and neck pain as the only manifestations, is an uncommon pathology, but is increasingly recognized as a cause of posterior circulation stroke in young adults. We report a case of VADA with isolated occipital headache at the time of onset and treatment using ...
Reyal Fabien F Institut Curie, Paris 75005, - - 2013
In March of 2010, French authorities suspended the use of breast implants made by the company Poly Implant Prothèse. Institut Curie is a large cancer center, and Poly Implant Prothèse was one major silicone-filled breast implant brand used. This report describes the impact of the fraudulent implants worldwide and more ...
Shi Hao H Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, - - 2013
Duchenne muscular dystrophy (DMD) is a degenerative skeletal muscle disease caused by mutations in dystrophin. The degree of functional deterioration in muscle stem cells determines the severity of DMD. The mitogen-activated protein kinases (MAPKs), which are inactivated by MAPK phosphatases (MKPs), represent a central signaling node in the regulation of ...
Yamaguchi H - - 2013
Epidermal growth factor receptor (EGFR) and human EGFR 2 (HER2) have an important role in the initiation and progression of various types of cancer. Inhibitors targeting these receptor tyrosine kinases are some of the most successful targeted anticancer drugs widely used for cancer treatment; however, cancer cells have mechanisms of ...
Zhang Y - - 2013
P63, a p53 family member, is expressed as TA and ΔN isoforms. Interestingly, both TAp63 and ΔNp63 are transcription factors, and regulate both common and distinct sets of target genes. p63 is required for survival of some epithelial cell lineages, and lack of p63 leads to loss of epidermis and ...
Haupt Samuel - - 2013
The age-related changes in ultraendurance performance have been previously examined for running and triathlon but not mountain biking. The aims of this study were (i) to describe the performance trends and (ii) to analyze the age-related performance decline in ultraendurance mountain biking in a 120-km ultraendurance mountain bike race the ...
Homa Karen - - 2013
OBJECTIVE:: The purpose of this study was to develop a cystic fibrosis (CF)-specific patient and family experience of care survey that CF care centers could use to inform quality improvement efforts. METHODS:: A literature search and query of CF care centers was conducted to identify existing surveys. Individuals with CF, ...
Frostad John M - - 2013
A new instrument is presented for investigating interactions between individual colloidal particles, emulsion droplets, foam bubbles, and other particle-particle or particle-surface interactions. Measurement capabilities are demonstrated by measuring interfacial tension, coalescence time for emulsion droplets, adhesion between giant multilamellar vesicles, and adhesion between model food emulsion particles. The magnitude of ...
Haugaa Kristina H KH Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, - - 2013
To determine the phenotype and outcome of patients with QTc of at least 500 ms and to create a pro-QTc risk score for mortality. An institution-wide computer-based QT alert system was developed and implemented at Mayo Clinic in Rochester, Minnesota. This system screens all electrocardiograms (ECGs) performed and alerts the ...
Vandarakis Dimitria - - 2013
This study determined the reliability of measuring resting metabolic rate (RMR) with COSMED's FitMate™ metabolic system using a canopy dilution set-up compared with a previously validated COSMED QUARK CPET research-based system in 30 healthy adults (age: 28.4 ± 7.0 yrs, weight: 79.9 ± 20.2 kg, percent body fat: 22.5 ± ...
Kerl Katrin - - 2013
: For the evaluation of data generated by multicolor fluorescence in situ hybridization (FISH), we present here a synergistic approach that integrates the 3 most commonly used numerical algorithms in conjunction with 2 newly devised graphic tools for data visualization, namely "signal curves" and "rhombic heat maps." These two graphic ...
Raijman Isaac - - 2013
Miniature endoscopes that can be introduced into the bile duct through the duodenoscope during endoscopic retrograde cholangiopancreatography were developed to allow nonsurgical management of difficult biliary stones. The direct visualization enabled by these cholangioscopes of the biliary epithelium provides additional data in the assessment of biliary strictures. Cholangioscopy allows assessment ...
Hancocks Stephen - - 2013
We have to be cautious about the safety to both individual and environmental health of all materials that we use and advocate.
Waljee Jennifer F JF Section of Plastic Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI 48109-0340, - - 2013
Surgeons are at risk for injury in the operating room daily. Because of the ubiquity of occupational hazards, injuries remain prevalent and expensive. Although occupational hazards can include musculoskeletal conditions, psychosocial stress, radiation exposure, and the risk of communicable diseases, sharps injuries remain the most common among surgeons in practice ...
Persichetti Paolo P Plastic and Reconstructive Surgery Unit and CIR, Laboratory of Chemistry and Biomaterial, Campus Bio-Medico di Roma University, Rome, - - 2013
In the last decade, an increase in complications related to dermal filler injections has been reported, especially in patients who underwent multiple treatments with different products. Imaging or histological examinations may suggest what kind of substance was used, but none can precisely identify the biomaterial. The aim of this study ...
Roberts William C - - 2013
Although it varies from center to center, the frequency of temporal artery biopsy in patients suspected of having temporal arteritis (TA) is relatively small. Most commonly, patients suspected of having TA are placed on prednisone for varying periods of time, and if symptoms disappear or lessen the diagnosis is made. ...
Kato Atsushi A Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, - - 2013
Adaptive humoral immune responses in the airways are mediated by B cells and plasma cells that express highly evolved and specific receptors and produce immunoglobulins of most isotypes. In some cases, such as autoimmune diseases or inflammatory diseases caused by excessive exposure to foreign antigens, these same immune cells can ...
Hermann Christopher D CD Petit Institute for Bioengineering and Bioscience, the Wallace H. Coulter Department of Biomedical Engineering, Atlanta, Ga, - - 2013
Craniosynostosis is the premature fusion of cranial sutures early in development. Mice are commonly used to study the mechanisms driving both normal and pathologic cranial suture development. Despite their frequency of use as a model, the time course of bone formation and mineralization during fusion of mouse posterior frontal suture ...
Yang Xiaodong X Department of Hand and Foot Surgery, Yiwu Central Hospital, Wenzhou Medical College, People’s Republic of - - 2013
There is a dearth of detailed published work on anterolateral leg perforators. The authors fully documented the vascular basis of the anterolateral leg perforator flap and report its use in reconstruction of distal extremities. Anterolateral leg perforators were investigated in 25 fresh cadavers and 10 casts of arteries. Fresh cadavers ...
Chase Kristin I - - 2013
The purposes of this study were to determine the incidence and distribution of injuries affecting collegiate competitive swimmers and to test possible injury risk factors. A prospective cohort design was used to follow 34 swimmers (16M, 18F) from an NCAA Division I Midwest University over one academic year. Exposure-based injury ...
Saxsena Aneeta - - 2013
Since the introduction of recombinant tissue plasminogen activator and thrombolysis, acute ischemic stroke has become a treatable disorder if the patient presents within the 4.5-hour time window. Typically, sporadic stroke is caused by atherosclerotic disease involving large or small cerebral arteries or secondary to a cardioembolic source often associated with ...
Herzog Raimund I RI Department of Internal Medicine, Section of Endocrinology, Yale School of Medicine, New Haven, Connecticut 06520-8040, USA. - - 2013
Hypoglycemia occurs frequently during intensive insulin therapy in patients with both type 1 and type 2 diabetes and remains the single most important obstacle in achieving tight glycemic control. Using a rodent model of hypoglycemia, we demonstrated that exposure to antecedent recurrent hypoglycemia leads to adaptations of brain metabolism so ...
Mishra S - - 2013
This study was focused to evaluate protection of indigenous antioxidant system of mice against gamma radiation-induced oxidative stress using a semiquinone (SQGD)-rich fraction isolated from Bacillus sp. INM-1. Male C57bl/6 mice were administered SQGD (50 mg/kgb.w.i.p.) 2 h before irradiation (10 Gy) and modulation in antioxidant enzymes activities was estimated at different time ...
Peng Jin - - 2013
Background Dual-energy CT (DECT) has been used to detect myocardial infarct. However, few comparable studies with histopathological findings as gold standard have been published. Purpose To investigate the accuracy of DECT iodine maps for detecting acute myocardial infarction compared with single photon emission computed tomography (SPECT) in a canine model ...
Hsu Joy J Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60637, - - 2013
The cause of chronic rhinosinusitis (CRS) remains unclear. Study of the genetic susceptibility to CRS might be a valuable strategy to understand the pathogenesis of this burdensome disorder. The purpose of this review is to critically evaluate the current literature regarding the genetics of CRS in a comprehensive fashion. The ...
Lee Michelle M Department of Plastic Surgery, Case Western Reserve University, Cleveland, Ohio 44106, - - 2013
The objective of the study was to determine whether botulinum toxin type A injections can serve as a prognosticator for migraine surgery success. Patients who underwent migraine surgery from 2000 to 2010 by the senior author (B.G.) were reviewed. Patients were included if they had botulinum toxin type A injection ...
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