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Results 401 - 450 of 2350
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Morrison Amanda S - - 2013
Research on social anxiety and social anxiety disorder has proliferated over the years since the explication of the disorder through cognitive-behavioral models. This review highlights a recently updated model from our group and details recent research stemming from the (a) information processing perspective, including attention bias, interpretation bias, implicit associations, ...
Fens Niki - - 2013
Abstract Introduction: Classification of COPD is currently based on the presence and severity of airways obstruction. However, this may not fully reflect the phenotypic heterogeneity of COPD in the (ex-) smoking community. We hypothesized that factor analysis followed by cluster analysis of functional, clinical, radiological and exhaled breath metabolomic features ...
Tonnerre Pierre - - 2013
MHC class I-related chain A (MICA) antigens are surface glycoproteins strongly implicated in innate immunity, and the MICA gene is highly polymorphic. Clinical observations suggest a role for donor MICA antigens expressed on transplant endothelial cells in the alloimmune response, but the effect of MICA genotype is not well understood. ...
Rossi Rosario - - 2013
INTRODUCTION: Several studies have definitively shown the benefit of mineralocorticoid receptor antagonists (MRAs) in patients with heart failure (HF). However, very few prior studies examined the relationship between the timing of initiation of MRAs and prognosis. In addition, on this topic, there is no information regarding the specific population of ...
Girvan Hazel M - - 2013
Heme is a prosthetic group best known for roles in oxygen transport, oxidative catalysis and respiratory electron transport. Recent years have seen heme's roles extended to sensors of gases such as oxygen (O2) and nitric oxide (NO) and cell redox state, and as mediators of cellular responses to changes in ...
Saleh Muneer Aziz - - 2013
An extensive survey was carried out for gamma dose rates (GDRs) in the Mersing district, Johor, Malaysia. The average value of GDR measured in the district was found to be 140 nGy h(-1), in the range of 40-355 nGy h(-1). The mean weighted dose rate to the population, annual effective ...
Yin Ze - - 2013
Novel PMMA opal photonic crystal/NaYF4:Yb(3+), Tm(3+)/Er(3+) nanocrystal composites were fabricated and tremendous improvement in upconversion luminescence (UCL) was observed under infrared 980 nm excitation. They were also explored to improve brightness of cell images.
Savoia Elena - - 2013
Introduction The objective of disaster preparedness is to ensure that appropriate systems, procedures, and resources are in place to provide prompt, effective assistance to disaster victims, thus facilitating relief measures and rehabilitation of services. Disaster preparedness efforts include the identification of possible health scenarios based on the probability of hazards ...
Porta Camillo - - 2013
In the 5th century B.C., Zeno of Elea offered arguments that led to conclusions contradicting what we all know from our experience. The arguments were paradoxes for the ancient philosophers and it took centuries to demonstrate that they were not true. For example, in his Achilles and the tortoise paradox, ...
Mpangase Phelelani - - 2013
BACKGROUND: Drug resistance to anti-malarial compounds remains a serious problem, with resistance to newer pharmaceuticals developing at an alarming rate. The development of new anti-malarials remains a priority, and the rational selection of putative targets is a key element of this process. Discovery-2 is an update of the original Discovery ...
Fischer Evelyn - - 2013
Context:Primary aldosteronism (PA) represents the most frequent cause of secondary arterial hypertension. Conflicting data have been published regarding the effect of aldosterone excess on glucose metabolism.Objective:Our aim was to analyze insulin sensitivity and beta cell function in a cohort of PA patients. Prospective follow-up investigations were performed in a subgroup ...
Maggioni Aldo P - - 2013
AIMS: The ESC-HF Pilot survey was aimed to describe clinical epidemiology and 1-year outcomes of outpatients and inpatients with heart failure (HF). The pilot phase was also specifically aimed at validating structure, performance, and quality of the data set for continuing the survey into a permanent Registry.MethodsThe ESC-HF Pilot study ...
Zwack Paul J - - 2013
Cytokinin Response Factor 6 (CRF6) is an Arabidopsis AP2/ERF transcription factor which is transcriptionally induced by cytokinin. Cytokinin is known to delay leaf senescence in WT plants, for example in dark-incubated detached leaves. This response is mediated by the cytokinin receptor AHK3. Similar to ahk3 mutants, crf6 leaves show decreased ...
Dasilva Jack G - - 2013
The pressure dependence of the magnetic properties of ferrimagnetic Mn(II)(TCNE)I(OH2) up to 14.05 kbar and Mn(II)(TCNE)3/2(I3)1/2·zTHF up to 14.32 kbar were studied. For Mn(II)(TCNE)I(OH2), two distinct pressure regions separated at ∼1 kbar were evident in both the temperature and the field-dependent magnetic measurements. No increase of the magnetic properties was ...
Padula Amy M - - 2013
Congenital anomalies are a leading cause of infant mortality and are important contributors to subsequent morbidity. Studies suggest associations between environmental contaminants and some anomalies, although evidence is limited. We aimed to investigate whether ambient air pollutant and traffic exposures in early gestation contribute to the risk of selected congenital ...
Marcais Ambroise - - 2013
The role of reduced intensity allogeneic stem cell transplantation for the treatment of relapsed/refractory Hodgkin lymphoma remains controversial. We retrospectively analyzed 191 patients who underwent reduced intensity allogeneic stem cell transplantation between 1998 and 2008 for relapsed or refractory Hodgkin lymphoma and whose data were reported to the French registry. ...
Fuwa Haruhiko - - 2013
(-)-Exiguolide (), isolated from the marine sponge Geodia exigua, has been shown to inhibit the growth of the A549 human lung adenocarcinoma and NCI-H460 human lung large cell carcinoma cells in vitro. In this study, we synthesized structural analogues of to explore its skeletal structure-activity relationships and found that the ...
Kuitwaard Krista - - 2013
OBJECTIVE: To determine the variability of serum IgG in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS: All 25 CIDP patients had active but stable disease and were treated with individually optimised fixed dose IVIg regimens. IgG was measured by turbidimetry and variability was defined as coefficient of variation (CV). ...
Wang Xiaoyan - - 2013
Abstract Purpose: The aim of this study was to investigate the effect of high-intensity focused ultrasound (HIFU) on immune function in patients with uterine fibroids, in a randomised comparison to conventional myomectomy. Methods: The patients were assigned (1:1) to the HIFU group or the myomectomy (MY) group. Venous blood samples ...
Del Zoppo Gregory J - - 2013
Appropriate acute treatment with plasminogen activators (PAs) can significantly increase the probability of minimal or no disability in selected ischemic stroke patients. There is a great deal of evidence showing that intravenous recombinant tissue PAs (rt-PA) infusion accomplishes this goal, recanalization with other PAs has also been demonstrated in the ...
Fischer Andreas - - 2013
Intestinal barrier dysfunction is pivotal in the etiology of inflammatory bowel diseases (IBD). Combined clinical and endoscopic remission ("mucosal healing") in patients receiving anti-TNF therapies suggests restitution of the intestinal barrier but the mechanisms involved are largely unknown. We therefore investigated the impact of the anti-TNF antibody adalimumab on barrier ...
Vent-Schmidt Thomas - - 2013
Reactions of laser-ablated U atoms with HF and DF in condensing and solid rare gas produce HUF and DUF as the major new products based on close agreement between observed and calculated vibrational frequencies and deuterium shifts for U-H and U-F stretching modes at 1383 and 544 cm(-1), respectively.
Brennan J Matthew - - 2013
BACKGROUND: There is a paucity of long-term data comparing biologic versus mechanical aortic valve prostheses in older individuals. METHODS AND RESULTS: We followed patients aged 65-80 years undergoing aortic valve replacement (AVR) with a biologic (n=24,410) or mechanical prosthesis (n=14,789) from 1991-1999 at 605 centers within the Society of Thoracic ...
Schenkel Fanny - - 2013
OBJECTIVES: We developed a population model that describes the ocular penetration and pharmacokinetics of penciclovir in human aqueous humour and plasma after oral administration of famciclovir. METHODS: Fifty-three patients undergoing cataract surgery received a single oral dose of 500 mg of famciclovir prior to surgery. Concentrations of penciclovir in both ...
Nauta Ferdau L - - 2013
BACKGROUND AND OBJECTIVES: Albuminuria is associated with risk for renal and cardiovascular disease. It is difficult to predict which persons will progress in albuminuria. This study investigated whether assessment of urinary markers associated with damage to different parts of the nephron may help identify individuals that will progress in albuminuria. ...
Lekich C - - 2013
OBJECTIVES: To describe a case of retained endovenous laser fibre. To review the literature and Food and Drug Administration device failure reports. To suggest protocols for avoiding this complication and a method of removal. METHODS: A case of retained fibre removal is described. Fibre removal techniques in vivo and ex ...
Monk Richard - - 2013
Abstract Background: Given the high cost of plasma derived intravenous alpha 1-antitrypsin (AAT), a more efficient method of delivery to the lungs is desirable. Inhaled AAT has been shown feasible for the treatment of alpha 1-antitrypsin deficiency (AATD) and is currently in clinical trials. To better understand patient preferences about ...
Singh Shalini - - 2013
Interactions with bacterial lipopolysaccharide (LPS), both in aqueous solution and in lipid membranes, were investigated for a series of amphiphilic peptides derived from the C-terminal region of human thrombin, using ellipsometry, dual polarization interferometry, fluorescence spectroscopy, circular dichroism (CD), dynamic light scattering, and z-potential measurements. The ability of these peptides ...
Smith Julie - - 2013
Plasma measurement of cardiac natriuretic peptides constitutes promising markers of congenital heart disease. However, concentrations change rapidly and dramatically during the first days after delivery even in healthy neonates, which complicates clinical interpretation. It is unknown whether these changes in plasma concentrations are explained by corresponding changes in the cardiac ...
Lowe Robert - - 2013
There is increasing evidence that interindividual epigenetic variation is an etiological factor in common human diseases. Such epigenetic variation could be genetic or non-genetic in origin, and epigenome-wide association studies (EWASs) are underway for a wide variety of diseases/phenotypes. However, performing an EWAS is associated with a range of issues ...
Boulouffe Caroline - - 2013
OBJECTIVES: Script concordance tests (SCTs) can be used to assess clinical reasoning, especially in situations of uncertainty, by comparing the responses of examinees with those of emergency physicians. The examinee's answers are scored based on the level of agreement with responses provided by a panel of experts. Emergency physicians are ...
Campa Claudio - - 2013
Objective: To evaluate the effect of 2 vascular endothelial growth factor (VEGF) isoforms (121 and 165) and 2 anti-VEGF compounds (ranibizumab and pegaptanib sodium) on the permeability of human retinal pigment epithelium (RPE) cells in vitro.
Methods: The RPE permeability was assessed on ARPE19 cells grown onto inserts of polytetrafluoroethylene previously ...
Bazzicalupi Carla - - 2013
The second-generation poly(ethylene imine) dendrimer (L), based on ammonia as the initiating core molecule, forms anion and ion-pair complexes in aqueous solution. Speciation of the complex species formed and determination of the relevant stability constants were performed by means of potentiometric titration in a 0.10 M NMe4Cl solution at 298.1 ...
Curci Antonietta - - 2013
In 2 studies, we assessed the construct validity of the Italian version of the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) version 2.0. In Study 1, we administered the MSCEIT together with measures of crystallized and fluid intelligence, personality, and affect. In Study 2, we administered the MSCEIT together with indexes of ...
Roos Katarina - - 2013
Activation of manganese-dependent class Ib ribonucleotide reductase by hydrogen peroxide was modeled using B3LYP* hybrid density functional theory. Class Ib ribonucleotide reductase R2 subunit (R2F) does not react with molecular oxygen. Instead R2F is proposed to react with H2O2 or HO2(-), provided by the unusual flavodoxin protein NrdI, to generate ...
Viana William Nascimento - - 2013
OBJECTIVE: /st>The objective of the study was to reduce the ventilator-associated pneumonia (VAP) incidence rates through a rational prevention program. DESIGN: /st>The study was a non-controlled clinical trial with a set of interventions in mechanically ventilated patients from April 2006 until June 2008. Pneumonia rates were analyzed as time series ...
Wang Anthony A - - 2013
Breath sampling and analysis provide healthcare professionals with a practical, noninvasive diagnostic measurement for children with a variety of gastrointestinal (GI) disorders. New biomarkers found in human breath have been investigated and provide the opportunity to diagnose bacterial overgrowth and other underlying causes of GI dysfunction. Although several protocols have ...
Visser Jenny A - - 2013
STUDY QUESTION: In girls and adolescents with Turner syndrome (TS), is there a correlation between serum AMH levels and karyotype, spontaneous puberty and other biochemical markers of ovarian function, or growth hormone (GH) therapy? SUMMARY ANSWER: Serum anti-Müllerian hormone (AMH) correlates with karyotype, pubertal development, LH, FSH and are measurable ...
Carlsson Britt-Marie - - 2013
Abstract Aim: This study examined long-term effects of continuous subcutaneous insulin infusion (CSII) in clinical practice on glycemic control in patients with type 1 diabetes. Subjects and Methods: We evaluated all type 1 diabetes patients at 10 diabetes outpatient clinics in Sweden who had been treated with CSII for at ...
Lin Yiming - - 2013
Ions in Matrix-Assisted Laser Desorption/Ionization (MALDI) are predominantly singly charged for small analyte molecules. With the estimated high number density and low temperature of electrons, the three-body recombination mechanism is attractive and should be considered as an important cause for the charge reduction in the plume. Theoretical calculations indicate that ...
Van Hilsen Zachary - - 2013
BACKGROUND: Optical caries detection has the potential to be incorporated in telehealth medicine for preventive dental screening. The objective of this study was to evaluate and compare visible and near infrared detection methods for identifying early non-cavitated ex vivo occlusal demineralization. METHODS: Six blinded examiners were used to compare the ...
Yang Li-Ming - - 2013
The equilibrium solid-state structure of the experimentally synthesized but incompletely characterized Zn4O(FMA)3 is revised with the help of density functional theory computational methods. The electronic structure, formation energy, chemical bonding, and optical properties of Zn4O(FMA)3 and its heavier congener Cd4O(FMA)3 have been systematically investigated. The calculated bulk moduli for Zn4O(FMA)3 ...
Ricupito Alessia - - 2013
While cancer vaccines are in the clinic, several issues remain to be addressed to increase vaccine efficacy. In particular, whether, how and how frequently a patient should be boosted remains to be defined. Here we have assessed the ability of dendritic cell (DC)-based vaccines to induce a long-lasting tumor-specific cytotoxic ...
Carroll Lauren N - - 2013
Introduction The emergency telephone number 9-1-1 serves as a lifeline to the public during emergencies, and first responders rely on information gathered by 9-1-1 telecommunicators who speak with callers. Timely, accurate information from the telecommunicators is essential for providing appropriate care on scene. Language barriers can hamper these efforts and ...
Collier Paul - - 2013
The substitution of valine with phenylalanine at amino acid 617 of the Janus kinase 2 (JAK2) gene (JAK2 p.V617F) occurs in a high proportion of patients with myeloproliferative neoplasms (MPNs). The ability to accurately measure JAK2 p.V617F allele burden is of great interest given the diagnostic relevance of the mutation ...
Mishra Shashikant - - 2013
Background: Patients presenting with varying severity of obstructive urolithiasis behave differently after the treatment. Some patients recover with improved renal function while others progress to renal failure. Objective: To objectively quantify which patient would progress to renal failure following treatment for obstructive urolithiasis. Material and methods: A prospective analysis of ...
García-Rio Francisco - - 2013
Abstract Our aim was to describe the population-based distribution of several COPD multi-dimensional indices and to evaluate their relationship with daily physical activity, co-morbidity, health status and systemic inflammatory biomarkers. From a population-based sample of 3,802 subjects aged 40-80 from the EPI-SCAN study, 382 subjects (10.2%) with a post-bronchodilator FEV1/FVC<0.7 ...
Chao Hsiao-Ming - - 2013
Abstract Purpose: Retinal ischemia-associated ocular disorders are vision threatening. This study examined whether the flavonoid baicalein is able to protect against retinal ischemia/reperfusion. Methods: Using rats, the intraocular pressure was raised to 120 mmHg for 60 min to induce retinal ischemia. In vitro, an ischemic-like insult, namely oxidative stress, was established by ...
Coppo Rosanna - - 2013
The term 'legacy effect'-a memory of a treatment which produces benefits long after the cessation of the intervention-was adopted for the first time to describe the benefits of early and strict control of diabetes on cardiovascular complications. The search for a similar effect for early treatment of immune-mediated renal diseases, ...
Desai Sapan S - - 2013
A 75-year-old man with invasive thymoma encasing the aortic arch and pulmonary arteries was referred to our institution with a 1-year history of dyspnea and worsening right heart failure. Pulmonary angiogram demonstrated greater than 90% stenosis of the right pulmonary artery. Balloon angioplasty and stent placement were performed with immediate ...
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