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Results 401 - 450 of 2362
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Harlev Eli - - 2013
The rapidly increasing incidence of diabetes mellitus is becoming a serious threat to mankind's health in all parts of the world. In fact, known cases reflect only part of the problem, as many diabetics, especially with type 2 diabetes, are unaware of their disease, which initially shows no definitive symptoms. ...
Miao Xiao - - 2013
BACKGROUND: Cardiovascular diseases remain a leading cause of the mortality world-wide, which is related to several risks, including the life style change and the increased diabetes prevalence. The present study was to explore the preventive effect of zinc on the pathogenic changes in the aorta. METHODS: A genetic type 1 ...
Bienaimé Frank F INSERM U845, Centre de Recherche Croissance et Signalisation, Université Paris Descartes, Hôpital Necker Enfants Malades, 149 Rue de Sèvres, 75015 Paris, France. - - 2013
Kidney transplant recipients usually have low vitamin D levels, especially in the early posttransplantation period, but the association between vitamin D status with renal outcomes is not well described in this population. Here, we studied a prospective cohort of 634 kidney recipients who underwent transplantation at a single institution between ...
Pablico-Lansigan Michele H - - 2013
Magnetic particle imaging (MPI) is an emerging biomedical imaging technology that allows the direct quantitative mapping of the spatial distribution of superparamagnetic iron oxide nanoparticles. MPI's increased sensitivity and short image acquisition times foster the creation of tomographic images with high temporal and spatial resolution. The contrast and sensitivity of ...
Burt Morton G - - 2013
Context:Measurement of plasma cortisol by immunoassay after ACTH1-24 stimulation is used to assess the hypothalamic-pituitary-adrenal (HPA) axis. Liquid chromatography-tandem mass spectrometry (LCMS) has greater analytical specificity than immunoassay and equilibrium dialysis allows measurement of free plasma cortisol.Objective:We investigated the use of measuring total and free plasma cortisol by LCMS and ...
Sweitzer Nancy K NK Division of Cardiovascular Medicine, University of Wisconsin, Madison, Wisconsin, USA. - - 2013
Changes in the cardiovascular system with age may predispose older persons to development of heart failure with preserved ejection fraction. Vascular stiffening, aortic pressure augmentation, and ventricular-vascular coupling have been implicated. We explored the potential for acute reductions in late systolic pressure augmentation to impact left ventricular relaxation in older ...
Burnett Benjamin J BJ Departments of Physiology and Biophysics, Weill Cornell Medical College, New York, New York 10065, - - 2013
Aminoacyl-tRNA (aa-tRNA) enters the ribosome in a ternary complex with the G-protein elongation factor Tu (EF-Tu) and GTP. EF-Tu·GTP·aa-tRNA ternary complex formation and decay rates are accelerated in the presence of the nucleotide exchange factor elongation factor Ts (EF-Ts). EF-Ts directly facilitates the formation and disassociation of ternary complex. This ...
Yilmaz Mehmet - - 2013
Nanoscale materials often have stochastic material properties due to a random distribution of material defects and an insufficient number of defects to ensure a consistent average mechanical response. Current methods to measure the mechanical properties employ MEMS-based actuators. The nanoscale specimens are typically mounted manually onto the load platform, so ...
Loukidou Evangelia - - 2013
Over the last three decades significant efforts have been made in many European countries to move away from a mental health system dominated by institutional care towards one whereby the main emphasis is on providing care and support within the community. Although the time of starting the reforms, their pace, ...
Yan Pisong - - 2013
Abstract Purpose: To evaluate the changes in posterior corneal surface (Q value and elevation) measured with Pentacam after femtosecond laser assisted Sub-Bowman Keratomileusis (SBK). Methods: The Q values and elevation of posterior corneal surface were determined in 166 myopic/myopic astigmatism eyes of 88 patients using Scheimpflug imaging (Pentacam; Oculus, Wetzlar, ...
Liu Qi - - 2013
Two novel 2D Ln-Cd HMOFs [Ln2Cd3(EDTA)3(H2O)11](H2O)14 (Ln = Sm 1; Eu 2; H4EDTA = ethylene diamine tetraacetic acid) based on nanosized heart-like Ln6Cd6O12 wheel-clusters were hydrothermally synthesized and characterized. The luminescence sensing of 2 to the polarization and concentration of cations was discussed.
Eakin Deborah K DK a Department of Psychology , Mississippi State University , Mississippi State , MS , - - 2014
Age differences in feeling-of-knowing (FOK) accuracy were examined for both episodic memory and semantic memory. Younger and older adults either viewed pictures of famous faces (semantic memory) or associated non-famous faces and names (episodic memory) and were tested on their memory for the name of the presented face. Participants viewed ...
Huang Liang - - 2013
Composite films of graphene oxide (GO) sheets and silk fibroin (SF) with layered structures have been prepared by facile solution casting of SF-GO hydrogels. The as-prepared composite film containing 15% (by weight, wt%) of SF shows a high tensile strength of 221 ± 16 MPa and a failure strain of ...
Tinuoye Olaitan - - 2013
INTRODUCTION: Studies suggest an association between secondhand smoke exposure and the development of childhood asthma. Several countries are considering legislation to protect children from exposure. METHODS: A systematic review was conducted using MEDLINE, Embase, PubMed, and Web of Knowledge databases and a random effects meta-analysis was undertaken. Heterogeneity was assessed ...
Crawley E E Centre for Child & Adolescent Health, School of Social & Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK. - - 2013
Chronic fatigue syndrome (CFS) is relatively common and disabling. Over 8000 patients attend adult services each year, yet little is known about the outcome of patients attending NHS services. Investigate the outcome of patients with CFS and what factors predict outcome. Longitudinal patient cohort. We used data from six CFS/ME ...
Wang Zhenghui Z Department of Chemistry, Washington University, St. Louis, MO 63130, - - 2013
Optical imaging of gene expression through the use of fluorescent antisense probes targeted to the mRNA has been an area of great interest. The main obstacles to developing highly sensitive antisense fluorescent imaging agents have been the inefficient intracellular delivery of the probes and high background signal from unbound probes. ...
Suranyi Eva - - 2013
Purpose: To evaluate the effect of plaque radiation therapy using beta-radioactive isotope for anterior segment tumors on the density and morphology of endothelial cells. ‚Ä©Methods: Endothelial cell density (ECD) and morphometry in 15 eyes of 15 patients with ciliary body tumor was examined prior to and 6 months after radiation ...
Onder Graziano - - 2013
Older patients are particularly vulnerable to adverse drug reactions (ADRs) because age is associated with changes in pharmacokinetics and pharmacodynamics that may alter drug metabolism. In addition, other conditions, commonly observed in older adults, may increase the risk of ADRs in the older population (including polypharmacy, comorbidity, cognitive and functional ...
Forkert N D - - 2013
BACKGROUND AND PURPOSE:The mismatch between lesions identified in perfusion- and diffusion-weighted MR imaging is typically used to identify tissue at risk of infarction in acute stroke. The purpose of this study was to analyze the variability of mismatch volumes resulting from different time-to-peak or time-to-maximum estimation techniques used for hypoperfused ...
Chen Howard H HH Martinos Center for Biomedical Imaging, Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, - - 2013
Autophagy is a biological process during which cells digest organelles in their cytoplasm and recycle the constituents. The impact of autophagy in the heart, however, remains unclear in part because of the inability to noninvasively image this process in living animals. Here, we report the use of fluorescence molecular tomography ...
Pinato David J - - 2013
BACKGROUND: The concentration of C-reactive protein (CRP), a biomarker of systemic inflammation, is determined by genetic, clinical and demographic factors including gender, smoking and body mass index (BMI). The influence of age on CRP dynamic changes following insult has, however, been poorly characterised. METHODS: We used unilateral hernia repair as ...
Haymart Megan R MR Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA. - - 2013
Little is known about practice patterns in thyroid cancer, a cancer that is increasing in incidence. We sought to identify aspects of thyroid cancer management that have the greatest variation. We surveyed 944 physicians involved in thyroid cancer care from 251 hospitals affiliated with the US National Cancer Database. Physicians ...
Tirosh Amit - - 2013
Abstract The authors' aim was to study the association between age and the quality of community health care of diabetes mellitus (DM). This was a cross-sectional study of patients with DM in the setting of a large health maintenance organization (HMO) in Israel. The population included DM patients aged 40-84 ...
Silva B C - - 2013
Lactic acid bacteria were isolated and identified in the faeces of Chinese Crested and Yorkshire terrier pups and their probiotic features were investigated in vitro. Thirty seven isolates were identified as Lactobacillus or Enterococcus. Out of these isolates, 31 were lactic acid bacteria (LAB) and belonged to the species Lactobacillus ...
Wu Jing - - 2013
In this work, a simple and versatile microfluidic cell density gradient generator was successfully developed for cytotoxicity of quantum dots (QDs) assay. The microfluidic cell density gradient generator is composed of eight parallel channels which are respectively surrounded by 1-8 microwells with optimized length and width. The cells fall into ...
Haarberg H Eirik HE Department of Molecular Oncology, The Moffitt Cancer Center & Research Institute, Tampa, FL 33612, - - 2013
The HSP90 inhibitor XL888 is effective at reversing BRAF inhibitor resistance in melanoma, including that mediated through acquired NRAS mutations. The present study has investigated the mechanism of action of XL888 in NRAS-mutant melanoma. Treatment of NRAS-mutant melanoma cell lines with XL888 led to an inhibition of growth, G2-M phase ...
Kharbanda Akriti A Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, - - 2013
Tamoxifen resistance of estrogen receptor-positive (ER+) breast cancer cells has been linked in part to activation of receptor tyrosine kinases, such as HER2, and the PI3K-AKT pathway. Mucin 1 (MUC1) is aberrantly overexpressed in about 90% of human breast cancers, and the oncogenic MUC1-C subunit is associated with ERα. The ...
Tian Fei - - 2013
Marek's disease (MD) is characterized as a T cell lymphoma induced by a cell-associated α-herpesvirus, Marek's disease virus type 1 (MDV1). As with many viral infectious diseases, DNA methylation variations were observed in the progression of MD; these variations are thought to play an important role in host-virus interactions. We ...
Jagadeesan Bharathi Dasan - - 2013
BACKGROUND AND PURPOSE: The difference in the relationship between the size of intracranial aneurysms (IAs) and their risk of rupture in patients with singe IAs versus those with multiple IAs is unclear. We sought to retrospectively analyze the size of ruptured IAs (RIAs) in patients with single and multiple IAs ...
Demondion Pierre - - 2013
OBJECTIVES: The total artificial heart (TAH) helps to counteract the current decrease in heart donors and is likely to bridge patients to transplant under favourable conditions. Today's mobile consoles facilitate home discharge. The aim of this study was to report on the La Pitie Hospital experience with CardioWest™ TAH recipients, ...
Najafi R - - 2013
Objective: Today, cell therapy is considered a promising alternative in treatment of several diseases such as type 1 diabetes. Loss of transplanted stem cell and more importantly scarcity in the number of cells reaching to target tissue is a major obstacle in cell therapy. There is evidences showing that deferoxamine ...
Rao A T - - 2013
SUMMARY:Alzheimer disease prevails as a major cause of disability in the elderly population and ranks as the most common form of dementia that affects 1 of 8 individuals older than 65 years of age. Most AD cases are late in onset and are probably influenced by both genetic and environmental ...
Hobbs Charlotte V CV Laboratory of Malaria Vaccinology and Immunology, NIH/NIAID, 12735 Twinbrook Pkwy, Rockville, MD 20852, USA. - - 2013
 Millions of individuals being treated for human immunodeficiency virus (HIV) live in malaria-endemic areas, but the effects of these treatments on malaria transmission are unknown. While drugs like HIV protease inhibitors (PIs) and trimethoprim-sulfamethoxazole (TMP-SMX) have known activity against parasites during liver or asexual blood stages, their effects on transmission ...
Kubota Masatoshi - - 2013
The effect of rice protein (RP) on diabetic nephropathy in non-obese, spontaneous type 2 diabetic Goto-Kakizaki (GK) rats was investigated. GK rats at 7 weeks of age were fed 20 % RP or casein (C) in standard or high-sucrose diets for 10 weeks. Plasma total cholesterol, TAG, alkaline phosphatase (ALP), adiponectin, ...
Nibhanipudi Kumara V - - 2013
Objective. A study to determine Spanish-speaking parents' acceptance of the physician's attire in the pediatric emergency department. Hypothesis. The attire of the physicians does not matter for the parents. Methods and materials. The sample size was 450. An anonymous patient survey with no identifiers was used. The sample questionnaire was ...
Branscum Paul - - 2013
The purpose of this study was to use the theory of planned behavior to explain two types of snack food consumption among boys and girls (girls n = 98; boys n = 69), which may have implications for future theory-based health promotion interventions. Between genders, there was a significant difference ...
Li Jia - - 2013
Investigations of complex metabolic mechanisms and networks have become a focus of research in the post-genomic area, thereby creating an increasing demand for sophisticated analytical approaches. One such tool are lipidomics analyses that provide a detailed picture of the lipid composition of a system at a given time. Introducing stable ...
Satué María - - 2013
The aim of the present study was to determine the effects of UV irradiation on the conversion of 7-dehydrocholesterol (7-DHC), which has been coated onto a polystyrene surface, to cholecalciferol (D3), and the resulting effect on the formation of vitamin D (1,25-D3) by MC3T3-E1 cells. The changes in gene expression ...
Grundeken Maik J - - 2013
OBJECTIVES: We evaluated 30-day and 1-year clinical outcomes after percutaneous or surgical coronary revascularisation in patients with unprotected left main coronary artery (ULMCA)-related acute myocardial infarction (AMI). DESIGN: Single-centre registry. PATIENTS: Between January 1998 and December 2008, 84 patients with ULMCA-related AMI underwent revascularisation treatment in our institution (55 underwent ...
Bresse Xavier - - 2013
This study assesses the cost-effectiveness of vaccination against herpes zoster (HZ) and postherpetic neuralgia in France, using a published Markov model. The cost-effectiveness of vaccinating individuals aged from 65 years or between 70 and 79 years was evaluated over their lifetime, from a third-party payer perspective. French-specific data were combined ...
Grogan Kelly - - 2013
The objective of this research was to develop a method suitable for the determination of aqueous concentrations of radioactive iodine as I2, I(-), and IO3(-). As one of the primary risk-drivers and contaminants of concern at nuclear waste repositories, the accurate determination of (129)I in aqueous systems is of significant ...
Zhang Quan - - 2013
Abstract Background: The increasing cost in terms of money and healthcare resources is driving healthcare providers to provide home-based telecare instead of institutionalized healthcare. Falling is one of the most common and dangerous accidents for elderly individuals and a significant factor affecting the living quality of the elderly. Many efforts ...
Rodríguez-Pérez Laura - - 2013
Graphene is a unique material with outstanding mechanical and electronic properties. For solution processes graphene layers have to be stabilized by means of molecular or supramolecular chemical derivatization, prior to their transfer to solid substrates. The most common chemical methodology for the preparation of graphene involves the formation of graphene ...
Seyhan Ekrem Cengiz EC Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Istanbul, Turkey. - - 2013
Cardiovascular disease (CVD) contributes significantly to mortality in chronic obstructive pulmonary disease (COPD). Red blood cell distribution width (RDW), an automated measure of red blood cell size heterogeneity that is largely overlooked, is a newly recognized mortality marker in patients with established CVD. It is unknown whether RDW is associated ...
Salamonsen Matthew - - 2013
ABSTRACT INTRODUCTION To reduce complications and increase success, thoracic ultrasound (US) is recommended to guide all chest drainage procedures. Despite this, no tools currently exist to assess proceduralist training or competence. This study aims to validate an instrument to assess physician skill at performing thoracic US including effusion mark-up, and ...
Chandra-Mouli Venkatraman - - 2013
As part of a multifaceted effort to respond to the needs of young people more effectively, the Ministry of Health of the Republic of Moldova established pilot Youth Friendly Health Centres (YFHC) in 2001.In 2005, after 12 YFHC were set up and implemented, the MOH identified that while they were ...
Klingensmith William C WC - - 2013
Our objective was to rigorously compare pinhole and parallel-hole collimation in an intrapatient, intrastudy design in 2 parathyroid imaging protocols: the first was dual-phase (99m)Tc-sestamibi imaging, and the second was dual-phase (99m)Tc-sestamibi plus dual-tracer ((99m)Tc-sestamibi and (123)I) simultaneous-acquisition subtraction imaging. METHODS: Thirty-three patients with 37 surgically proven nonectopic parathyroid adenomas ...
Suffredini G - - 2013
SUMMARY:Advances in nanotechnology have the potential to dramatically enhance the detection of neurologic diseases with targeted contrast agents and to facilitate the delivery of focused therapies to the central nervous system. We present the physicochemical rationale for their use, applications in animal models, and ongoing clinical trials using these approaches. ...
Derman Wayne - - 2013
BACKGROUND: In this study we describe (1) the implementation of a novel web-based injury and illness surveillance system (WEB-IISS) for use by a team of physicians at multisport events and (2) the incidence and characteristics of injuries and illness in athletes during the London 2012 Paralympic Games. METHODS: Overall, 3565 ...
Ossenkoppele Rik - - 2013
A potential mechanism that enables intellectual preservation in cognitively normal elderly that harbor beta-amyloid (Aβ) pathology is heightened cerebral glucose metabolism. To investigate cross-sectional inter-relationships between Aβ, glucose metabolism, and cognition, 81 subjects (mean age: 75 ± 7 years) underwent [(11)C]Pittsburgh Compound-B and [(18)F]fluorodeoxyglucose positron emission tomography scans and neuropsychological ...
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