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Kim Ko Eun - - 2013
PURPOSE: To compare the detection of localized retinal nerve fiber layer (RNFL) defects by two different spectral domain optical coherence tomography (SD-OCT) devices. METHODS: Eyes of 42 normal control subjects and 48 patients with a localized RNFL defect on red-free fundus photographs were imaged by the Cirrus (Carl Zeiss Meditec, ...
Butina Tatyana V - - 2013
Numerous studies revealed high diversity of T4-like bacteriophages in various environments, but so far, little is known about T4-like virus diversity in freshwater bodies, particularly in eutrophic lakes. The present study was aimed at elucidating molecular diversity of T4-like bacteriophages in eutrophic Lake Kotokel located near Lake Baikal by partial ...
Li Yating - - 2013
  Ten eudesmanolides (1-10) including five new ones (1-4 and 6) were isolated from the whole plant of Wedelia trilobata (L.) Hitchc., a notorious invasive weed in South China. As main constituents of W. trilobata, eight of these eudesmanolides were tested for their antitobacco mosaic virus (TMV) activities by the conventional ...
Zhang Jing - - 2013
Cardiovascular disease (CVD) begins early in the course of chronic kidney disease (CKD) and is the leading cause of death in patients with CKD. Preventing the development of CVD and establishing new clinical tools for identifying high-risk individuals, particularly those with an increased risk for cardiac death, is of clinical ...
Hill Karl G - - 2013
The objectives of this study were to examine (1) whether the onset of sexually transmitted infections (STI) through age 30 differed for youths who received a social developmental intervention during elementary grades compared to those in the control condition; (2) potential social-developmental mediators of this intervention; and (3) the extent ...
Zhang Jinsong - - 2013
The breaking of time reversal symmetry in topological insulators may create previously unknown quantum effects. We observed a magnetic quantum phase transition in Cr-doped Bi2(SexTe1-x)3 topological insulator films grown by means of molecular beam epitaxy. Across the critical point, a topological quantum phase transition is revealed through both angle-resolved photoemission ...
Pietrogrande Maria Chiara - - 2013
Traces of prebiotic amino acids, i.e., the building blocks of proteins, are excellent biomarkers that could provide evidence of extinct or extant life in extra-terrestrial environments. In particular, characterization of the enantiomeric excess of amino acids gives relevant information about the biotic or abiotic origin of molecules, because it is ...
Ayabe Shinya - - 2013
Lung fibroblasts are responsible for collagen secretion during normal tissue repair and the development of fibrosis. Many other prostaglandins have been reported to regulate collagen synthesis in lung fibroblasts, but the role of prostaglandin D2 (PGD2) is unknown. In this study, we investigated the effect of PGD2 on type I ...
Nichols Colin G CG Center for the Investigation of Membrane Excitability Diseases and Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. - - 2013
ATP-sensitive potassium (KATP) channels were first discovered in the heart 30 years ago. Reconstitution of KATP channel activity by coexpression of members of the pore-forming inward rectifier gene family (Kir6.1, KCNJ8, and Kir6.2 KCNJ11) with sulfonylurea receptors (SUR1, ABCC8, and SUR2, ABCC9) of the ABCC protein subfamily has led to ...
Quinn Gwendolyn P - - 2013
Rapid tissue donation (RTD) is an advancing oncology research procedure for collecting tumors, metastases, and unaffected tissue 2-6 h after death. Researchers can better determine rates of progression, response to treatment, and polymorphic differences among patients. Cancer patients may inquire about posthumous body donation for research to offer a personal contribution ...
Westerhout Joost - - 2013
In the development of central nervous system (CNS)-targeted drugs, the prediction of human CNS target exposure is a big challenge. Cerebrospinal fluid (CSF) concentrations have often been suggested as a 'good enough' surrogate for brain extracellular fluid (brainECF, brain target site) concentrations in humans. However, brain anatomy and physiology indicates ...
Marimuthu Andiappan - - 2013
Oxidation of functioning copper has restricted its applicability as a catalyst for commercially important epoxidation of propylene to form propylene oxide. Here, we report that steady-state selectivity in propylene epoxidation on copper (Cu) nanoparticles increases sharply when the catalyst is illuminated with visible light. The selectivity increase is accompanied by ...
Chiu Tai-Chia - - 2013
This article highlights recent methodological developments in the on-line concentration and separation of amino acids and their enantiomers using capillary electrophoresis. Sections are dedicated to recent contributions to on-line concentration strategies such as field-amplified sample stacking, large-volume sample stacking, dynamic pH junction, transient isotachophoresis, sweeping, and the combination of two ...
Hudson Lee D - - 2013
In most high-income countries, fewer children now acquire meningitis, and many of those who do will survive. Globally, however, meningitis still remains a significant cause of child morbidity and mortality. In this article, the authors review recent evidence on the morbidity faced by childhood survivors of bacterial meningitis. Outcomes vary ...
Cheatum Christopher M - - 2013
At physiological temperatures, enzymes exhibit a broad spectrum of conformations, which interchange via thermally activated dynamics. These conformations are sampled differently in different complexes of the protein and its ligands, and the dynamics of exchange between these conformers depends on the mass of the group that is moving and the ...
Tural Deniz - - 2013
Background/Aims: Cetuximab is currently approved for the treatment of metastatic colorectal cancer (mCR) with KRAS wild-type. Prior few studies demonstrated that G13D mutated tumors could benefit from cetuximab. This study aims to investigate whether KRAS G13D mutated tumors benefit from cetuximab in the chemotherapy refractory patients. Methodology: We retrospectively compared ...
Kochhann Daiani - - 2013
Despite safety protocols, crude oil extraction and transportation in the Amazon basin has a potential for inadvertent oil spills, which can impact aquatic organisms in local rivers. The objective of this study was to assess the effects of crude oil on juvenile Amazonian fish tambaqui, Colossoma macropomum, at various biological ...
Hussain Khalid - - 2013
We discuss a 10-year experience of all the thyroglossal duct cysts (TGDC) removed at our institution, assessing whether management was appropriate and to compare our outcomes and success rate with current literature. We performed a retrospective review of TGDC surgery at our institution from 2000 to 2010. During the study ...
Kandeel Manal - - 2013
A variety of novel thieno[3,2-d]pyrimidines with different decorating functional groups were synthesized as a part of a study aiming to enrich the arsenal of chemotherapeutic agents for the treatment of cancer. The design of synthetic molecules based on DNA-interchelating properties by hydrogen bond formation. The reported compounds herein are: 4-aminothienopyrimidine ...
Long Manhai - - 2013
Perfluoroalkyl acids (PFAAs) are perfluorinated compounds that widely exist in the environment and can elicit adverse effects including endocrine disruption in humans and animals. This study investigated the effect of seven PFAAs on the thyroid hormone (TH) system assessing the proliferation of the 3,3',5-triiodo-L-thryonine (T3)-dependent rat pituitary GH3 cells using ...
Camarda Lawrence - - 2013
PURPOSE: A suture passed along the part of the graft that will be inserted into the femoral tunnel is widely used by surgeons, because it could prevent the graft sliding on the femoral fixation device during pulling from the tibial side. The aim of this study was to evaluate the ...
Hu Yue-Jian - - 2013
The objective of this study was to investigate the compositional profiles and microbial shifts of oral microbiota during head-and-neck radiotherapy. Bioinformatic analysis based on 16S rRNA gene pyrosequencing was performed to assess the diversity and variation of oral microbiota of irradiated patients. Eight patients with head and neck cancers were ...
Cronholm Peter F PF Department of Family Medicine and Community Health, The University of Pennsylvania, Philadelphia, PA 19104, USA. - - 2013
The Patient-Centered Medical Home (PCMH) has become a dominant model of primary care re-design. The PCMH model is a departure from more traditional models of healthcare delivery and requires significant transformation to be realized. To describe factors shaping mental models and practice culture driving the PCMH transformation process in a ...
Johnson Timothy R - - 2013
A Thurstonian model for ranking data assumes that observed rankings are consistent with those of a set of underlying continuous variables. This model is appealing since it renders ranking data amenable to familiar models for continuous response variables-namely, linear regression models. To date, however, the use of Thurstonian models for ...
Cordell Barbara B Panola College, Carthage, Texas, USA. - - 2013
To evaluate the effect of two inhaled essential oils (black pepper or angelica) on the nicotine habits of students, staff, and faculty on a U.S. college campus. Comparative study with pre-/post-test measures. Community college in rural East Texas. Convenience sample of 20 volunteers from the college community (students, faculty, and ...
Getz Jennifer A - - 2013
Neuropilin-1 and -2 are critical regulators of angiogenesis, lymphangiogenesis, and cell survival as receptors for multiple growth factors. Disulfide-rich peptides that antagonize the growth factor receptors neuropilin-1 and neuropilin-2 were developed using bacterial display libraries. Peptide ligands specific for the VEGFA binding site on neuropilin-1 were identified by screening a ...
Chen Chia-Yen CY Department of Epidemiology, Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA. - - 2013
Inference of ancestry using genetic data is motivated by applications in genetic association studies, population genetics and personal genomics. Here, we provide methods and software for improved ancestry inference using genome-wide single nucleotide polymorphism (SNP) weights from external reference panels. This approach makes it possible to leverage the rich ancestry ...
Coyne-Beasley Tamera - - 2013
Objective. Adolescent meningococcal vaccine uptake remains low. We examined vaccine awareness among parents of adolescents and uptake. Methods. Parents of adolescents aged 11 to 17 years (n = 1281) participated in a statewide survey. Logistic regression with weighted data provided population-based estimates. Results. In all, 65% had heard of meningococcal ...
Kanno Hiromi H Laboratory of Cancer Research, Department of Pathology, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, - - 2013
CD163 is a 130-kDa transmembrane protein expressed in human monocytes and macrophages, and the aberrant expression of CD163 in breast and colorectal cancer associated with patients' poor prognosis was reported. Here, we analyzed the expression of CD163 in meningioma, a common intracranial tumor, and its molecular mechanism in association with ...
Le Huynh-Nhu - - 2013
We conducted exit interviews with a random sample of 39 predominantly Central American immigrant mothers who had completed a longitudinal randomized controlled trial to prevent perinatal depression. We found that rates and levels of perinatal depression in the intervention and control groups were lower than expected and did not differ ...
Grgić Helena - - 2013
Abstract This study examined cytokine gene expression patterns associated with fowl adenovirus (FAdV) infection. The selected cytokine mRNA was quantified by quantitative real-time reverse transcription-PCR in spleen, liver, and cecal tonsil during the course of infection of chickens with a serotype 8 FAdV (FAdV-8). Compared to uninfected chickens, infected birds ...
Amir Amirah - - 2013
BACKGROUND: Anopheles cracens has been incriminated as a vector for the simian malaria parasite, Plasmodium knowlesi, that is the fifth Plasmodium species infecting humans. Little experimental data exists on this mosquito species due to the lack of its availability in laboratories. FINDINGS: The population of An. cracens, collected from Kuala ...
Golenberg Edward M - - 2013
Most models for dioecy in flowering plants assume that dioecy arises directly from hermaphroditism through a series of independent feminizing and masculinizing mutations that become chromosomally linked. However, dioecy appears to evolve most frequently through monoecious grades. The major genetic models do not explain the evolution of unisexual flowers in ...
Padělková Zdeňka - - 2013
The reactivity of (L(CN))2Sn () (where L(CN) is 2-(N,N-dimethylaminomethyl)phenyl-) towards various substrates containing E-Cl bond(s) has been studied (E = C, Si, Ge and Sn). Alkyl chlorides like chloroform or dichloromethane reacts with to form (L(CN))2SnCl2 and unidentified by-products in poor yields. The reaction of benzoyl chloride with at low ...
Saha Dipankar - - 2013
High resolution synchrotron X-ray diffraction, dielectric and Raman scattering study of a scheelite compound Li0.5Ce0.5MoO4 (LCM) revealed that it transforms to a self similar structure above 400 °C. The thermally induced isostructural phase transition (IPT), a phenomenon which has rarely been reported in the literature, is preceded by partial softening ...
Karim Farheen - - 2013
BACKGROUND: The enzyme involved in regulating the size of vWF (von Willebrand factor) in plasma is ADAMTS-13 (A disintegrin and metalloprotease with thrombospondin type-1 motives). Deficient proteolysis of ULvWF (ultra large von Willebrand factor) due to reduced ADAMTS-13 activity results in disseminated platelet-rich thrombi in the microcirculation characteristic of thrombotic ...
Mancini Giada - - 2013
Rapid facial mimicry (RFM) is an automatic response, in which individuals mimic others' expressions. RFM, only demonstrated in humans and apes, is grounded in the automatic perception-action coupling of sensorimotor information occurring in the mirror neuron system. In humans, RFM seems to reflect the capacity of individuals to empathize with ...
Gory B - - 2013
BACKGROUND AND PURPOSE:Five commercial devices are available for mechanical thrombectomy in acute ischemic stroke. This study evaluated and compared the resultant arterial damage from these devices.MATERIALS AND METHODS:Wall damage after 4 wall-contact devices (the Merci retriever, Catch thromboembolectomy system, and Solitaire FR revascularization devices of 4 and 6 mm) and ...
Potthoff Karin - - 2013
BACKGROUND: Cancer-related fatigue (CRF) is one of the most common and distressing side effects of cancer and its treatment. During and after radiotherapy breast cancer patients often suffer from CRF which frequently impairs quality of life (QoL). Despite the high prevalence of CRF in breast cancer patients and the severe ...
Trappe Todd A TA Human Performance Laboratory, Ball State University, Muncie, - - 2013
It has been ∼40 yr since the discovery that PGs are produced by exercising skeletal muscle and since the discovery that inhibition of PG synthesis is the mechanism of action of what are now known as cyclooxygenase (COX)-inhibiting drugs. Since that time, it has been established that PGs are made ...
Katznelson Laurence - - 2013
Nelson's syndrome refers to aggressive pituitary corticotroph adenoma growth after bilateral adrenalectomy for treatment of Cushing's disease (CD). Pasireotide, a novel somatostatin analog, has been effective in treating CD. Here, the first case report of a patient with Nelson's syndrome treated with pasireotide is presented. A 55-year-old female was diagnosed ...
Wang Yupeng - - 2013
SUMMARY: Gene duplication occurs via different modes such as segmental and single-gene duplications. Transposed gene duplication, a specific form of single-gene duplication, 'copies' a gene from an ancestral chromosomal location to a novel location. MCScanX is a toolkit for detection and evolutionary analysis of gene colinearity. We have developed MCScanX-transposed, ...
Sakurai Takuya - - 2013
Recently, the ability of polyphenols to reduce the risk of dementia and Alzheimer's disease (AD) has attracted a great deal of interest. In the present study, we investigated the attenuating effects of oligomerised lychee fruit-derived polyphenol (OLFP, also called Oligonol) on early cognitive impairment. Male senescence-accelerated mouse prone 8 (SAMP8) ...
Mohammadpoorasl Asghar - - 2013
Risk-taking behaviors have negative consequences on adolescent and young adult's health. The aim of this study was to identify the subgroups of college students on the basis of risk-taking behaviors and to assess the role of demographic characteristics, religious beliefs, and parental support on membership of specific subgroup. The cross-sectional ...
Hanak Natasa - - 2013
We present details about the validation of the Serbian version of the Experiences in Close Relationships-Revised questionnaire modified to measure attachment in close relationships in general (SM-ECR-R). Its psychometric features were examined with 2 samples of students (N = 719 and N = 91) and 1 group of employed adults ...
Hung Shan-Ling - - 2013
Background: Hyperglycemia is widely considered as the causal link between diabetes and diabetic complications. The purpose of this study was to determine the effects of high glucose in the presence of lipopolysaccharide (LPS) purified from the periodontal pathogen, Porphyromonas gingivalis, on human macrophages. Methods: Macrophages (U937) were treated with various ...
Etminan Nima N Department of Neurosurgery, Medical Faculty, Heinrich-Heine-University, Moorenstraße 5, 40225-Düsseldorf, - - 2013
To date, there is no immediate radiographic surrogate to quantify primary cerebral injury to identify patients at risk for delayed cerebral ischemia and poor clinical outcome after aneurysmal subarachnoid hemorrhage. Therefore, we investigated the relation of early cerebral perfusion-computerized tomography and clot volume with radiological events of delayed cerebral ischemia ...
Ryan Natalie S NS Dementia Research Centre, Box 16 National Hospital for Neurology and Neurosugery, Queen Square, London WC1N 3BG, UK. - - 2013
Amyloid imaging studies of presymptomatic familial Alzheimer's disease have revealed the striatum and thalamus to be the earliest sites of amyloid deposition. This study aimed to investigate whether there are associated volume and diffusivity changes in these subcortical structures during the presymptomatic and symptomatic stages of familial Alzheimer's disease. As ...
Wohlfart Paulus - - 2013
BACKGROUND: Lixisenatide is a glucagon-like peptide-1 analog which stimulates insulin secretion and inhibits glucagon secretion and gastric emptying. We investigated cardioprotective effects of Lixisenatide in rodent models reflecting the clinical situation METHODS: The acute cardiac effects of Lixisenatide were investigated in isolated rat hearts subjected to brief ischemia and reperfusion. ...
Hansen Amanda G AG Department of Cancer Biology, Vanderbilt University, Nashville, TN, - - 2013
Molecular biomarkers of cancer are needed to assist histologic staging in the selection of treatment, outcome risk stratification, and patient prognosis. This is particularly important for patients with early-stage disease. We show that shedding of the extracellular domain of activated leukocyte cell adhesion molecule (ALCAM) is prognostic for outcome in ...
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