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Hughes Harriet - - 2013
Experiments and field trials have shown that the intracellular bacterium Wolbachia may be introduced into populations of the mosquito Aedes aegypti, the primary vector for dengue fever. In the absence of Wolbachia, a mosquito acquiring the dengue virus from an infected human enters an exposed (infected but not infectious) period ...
Bazrafshan Babak - - 2013
The purpose of this study was to evaluate magnetic resonance (MR) temperature imaging of the laser-induced thermotherapy (LITT) comparing the proton resonance frequency (PRF) and T 1 thermometry methods. LITT was applied to a liver-mimicking acrylamide gel phantom. Temperature rise up to 70 °C was measured using a MR-compatible fiber-optic thermometer. ...
Núñez-Pons Laura - - 2013
Alcyonacean soft corals lack physical or skeletal defenses and their nematocyst system is weak, leading to the conclusion that soft corals mainly rely on chemistry for protection from predators and microbes. Defensive chemicals of primary and secondary metabolic origin are exuded in the mucus surface layer, explaining the general lack ...
Bassi Ana Paula Guarnieri - - 2013
The alcoholic fermentation in Brazil displays some peculiarities because the yeast used is recycled in a non-aseptic process. After centrifugation, the cells are treated with acid to control the bacterial growth. However, it is difficult to manage the indigenous yeasts without affecting the main culture of Saccharomyces cerevisiae. This work ...
Coquerel David - - 2013
Septic shock has a high mortality rate, partially related to myocardial dysfunction. Polyunsaturated fatty acids (omega-3 PUFAs) possess anti-inflammatory and antioxidant properties, but whether omega-3 PUFAs exert beneficial effects on myocardial function is unknown. We investigated, in a rat model of endotoxic shock, the effects of omega-3 PUFAs pretreatment on ...
Yehouenou A Pazou Elisabeth - - 2013
To determine possible human and environmental health risks, organochlorine pesticide residues were determined in vegetables grown in floodplains along the Ouémé River near Lowé in Bénin. Testing of vegetables found 13 pesticides with ΣDDT, α-endosulfan, Σdrin, and lindane being most important. The same pesticides were also detected in plants eaten ...
Hill B - - 2013
Limiting gestational weight gain (GWG) to recommended levels is important to optimize health outcomes for mother and baby. Surprisingly, a recent review revealed that theory-based interventions to limit GWG were less effective than interventions that did not report a theory-base; however, strict criteria were used to identify theory-informed studies. We ...
Fan Xiaobin - - 2013
Cervical squamous carcinoma is a highly invasive tumour that has a great capacity to metastasise. Extracellular matrix metalloproteinase inducer (EMMPRIN or CD147), a member of the immunoglobulin superfamily, is a widely distributed cell surface glycoprotein. It is highly expressed on malignant tumour cell surfaces, including human cervical squamous carcinoma. It ...
Zhang Liuping - - 2013
PURPOSE: To evaluate the effect of proteasome inhibitor MG132 in cancer cachexia and to delineate the molecular mechanism underlying. METHODS: We established an experimental cancer cachexia model by subcutaneously implanting colon 26 cells into the armpits of BALB/c mice. Following administration of MG132 at various time points, body weight, food ...
Hölzel Michael - - 2013
Immunotherapies, signal transduction inhibitors and chemotherapies can successfully achieve remissions in advanced stage cancer patients, but durable responses are rare. Using malignant melanoma as a paradigm, we propose that therapy-induced injury to tumour tissue and the resultant inflammation can activate protective and regenerative responses that represent a shared resistance mechanism ...
Kashihara Koji - - 2013
Involuntary microsaccades and voluntary saccades reflect human brain activities during attention and cognitive tasks. Our eye movements can also betray our emotional state. However, the effects of attention to emotion on microsaccadic activity remain unknown. The present study was conducted in healthy volunteers to investigate the effects of devoting attention ...
Li Lin - - 2013
Protein phosphorylation and dephosphorylation events play a key role in memory formation and various protein kinases and phosphatases have been firmly associated with memory performance. Here, we determined expression changes of protein kinases and phosphatases following retrieval of spatial memory in CD1 mice in a Morris Water Maze task, using ...
Bamford Laura - - 2013
Emergency Departments (EDs) provide primary healthcare to many underserved persons without access to preventive healthcare elsewhere. We conducted a cross-sectional study to test the hypothesis that patients are more likely to express a willingness to accept rapid HIV testing in the ED if they lack access to preventive healthcare elsewhere. ...
Rodriguez-Falces Javier - - 2013
Introduction: To investigate differences in twitch and M-wave potentiation in the quadriceps femoris when electrical stimulation is applied over the quadriceps muscle belly versus the femoral nerve trunk. Methods: M-waves and mechanical twitches were evoked using direct quadriceps muscle and femoral nerve stimulation between 48 successive isometric maximal voluntary contractions ...
Fam Hok Khim - - 2013
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that processes blocked 3' ends of DNA breaks. Functional loss of Tdp1 causes spinocerebellar ataxia with axonal neuropathy type 1 (SCAN1). Based on the prominent cytoplasmic expression of Tdp1 in the neurons presumably affected in SCAN1, we hypothesized that Tdp1 participates ...
Franchi Carlotta - - 2013
PURPOSE: To compare the geographical differences in the prevalence of chronic polypharmacy in community-dwelling older people over 11 years. METHODS: This study analyzed nearly two million patients aged 65-94 years recorded in the Drug Administrative Database of the Lombardy Region (Northern Italy) from 2000 to 2010. Chronic polypharmacy was defined as taking ...
Chou Kuo-Chen - - 2013
Many molecular biosystems and biomedical systems belong to the multi-label systems in which each of their constituent molecules possesses one or more than one function or feature, and hence needs one or more than one label to indicate its attribute(s). With the avalanche of biological sequences generated in the post ...
Zhu Liang - - 2013
The combination of zero-valent iron (ZVI) with anaerobic sludge for enhancing reductive transformation and dechlorination of p-chloronitrobenzene (p-ClNB) was investigated in this study. p-ClNB was quickly reduced into p-chloroaniline (p-ClAn) and subsequently dechlorinated into aniline in the complex system, and the strengthening factor for pseudo-first-order transformation rate constant of p-ClNB ...
Bayliss M - - 2013
This paper presents a multi-method research project to develop a conceptual framework for measuring outcomes in studies of osteoporotic kyphosis. The research involved literature research and qualitative interviews among clinicians who treat patients with kyphosis and among patients with the condition. INTRODUCTION: Kyphosis due to at least one vertebral compression ...
van Liempd S - - 2013
We developed an assay for the extraction and simultaneous quantitation of five key metabolites of the methionine metabolic pathway in liver tissue. The metabolites included were 5'-methylthioadenosine, methionine, homocysteine, S-adenosyl-L-homocysteine, and S-adenosyl-L-methionine. The metabolites were extracted using a bead-based homogenization method, and quantitation was carried out using hydrophilic interaction chromatography ...
Landau Susan M - - 2013
Objective: We examined agreement and disagreement between two biomarkers of Aß deposition (amyloid PET and CSF Aß1-42 ) in normal aging and dementia in a large multicenter study. Methods: Concurrently acquired florbetapir-PET and CSF Aß were measured in cognitively normal, mild cognitive impairment (MCI), and Alzheimer's disease (AD) participants (N=374) ...
Gyselinck Valérie - - 2013
The aim of this study is to broaden our understanding of the construction and early decline of spatial mental representations in route learning, considering the extent to which spatial ability and age-related differences in environment learning interact. The experiment examines spatial mental representation derived from taking a realistic route acquired ...
Kim Yu-Jin - - 2013
Multicellular layers (MCL) of cancer cells is an in vitro 3-dimensional (3D) model that mimics avascular microregions of human solid tumors and has been shown to be useful in pharmacokinetic-pharmacodynamic studies of anticancer agents. We investigated whether Ki-67, which is widely used as a proliferation marker, can be used to ...
Heldermon C D CD Department of Medicine, University of Florida, Gainesville, FL 32610, USA. - - 2013
Mucopolysaccharidosis type IIIB (MPS IIIB) or Sanfilippo Syndrome type B is a lysosomal storage disease resulting from the deficiency of N-acetyl glucosaminidase (NAGLU) activity. We previously showed that intracranial adeno-associated virus (AAV)-based gene therapy results in partial improvements of several aspects of the disease. In an attempt to further correct ...
Hattori Yuko - - 2013
Humans actively use behavioral synchrony such as dancing and singing when they intend to make affiliative relationships. Such advanced synchronous movement occurs even unconsciously when we hear rhythmically complex music. A foundation for this tendency may be an evolutionary adaptation for group living but evolutionary origins of human synchronous activity ...
Ghorbanian Parham - - 2013
Alzheimer's disease (AD) is associated with deficits in a number of cognitive processes and executive functions. Moreover, abnormalities in the electroencephalogram (EEG) power spectrum develop with the progression of AD. These features have been traditionally characterized with montage recordings and conventional spectral analysis during resting eyes-closed and resting eyes-open (EO) ...
Zhang W - - 2013
HLA-A*33:03:11 differs from A*33:03:01 by one nucleotide substitution in exon 3 at position 531 G>A.
Hachem May El - - 2013
Dermatofibrosarcoma protuberans (DFSP) is a low-grade, mesenchymal, spindle cell tumor. In addition to the classical form characterized by a storiform pattern of tumor cells, pigmented (Bednar's tumor) and myxoid variants can be observed. Classical DFSP and Bednar's tumor are easily diagnosed. The myxoid variant represents a diagnostic challenge. Pigmented and ...
Horton Terzah - - 2013
It is with great interest that we have watched the results of the studies done in mice suggesting that bortezomib treatment could be deleterious to bone health in children. These concerns have been extrapolated from a recent report (1) which suggests that bortezomib can decrease bone growth velocity and bone ...
Zhou Lijuan - - 2013
Fatty acid-binding protein 3 (FABP3) is a low molecular weight protein with distinct tissue distribution, which may play an important role in fatty acid transport, cell growth, cellular signaling, and gene transcription. We have previously shown FABP3 was more highly expressed in myocardium with ventricular septal defects than in normal ...
De Cremer Kaat - - 2013
The fungal pathogen Botrytis cinerea establishes a necrotrophic interaction with its host plants, including lettuce (Lactuca sativa), causing it to wilt, collapse and eventually dry up and die, which results in serious economic losses. Global expression profiling using RNAseq and the newly sequenced lettuce genome identified a complex network of ...
Røsand Gun-Mette B - - 2013
PURPOSE: There has been a marked increase in divorce rates in most Western societies over the last 50 years. Relationship dissolution is associated with negative consequences both for adults and children, so it is important to understand the factors that help retain marital stability. The first aim of this prospective study ...
Kang Yuan-Yuan - - 2013
We reviewed studies of ambulatory blood pressure monitoring (ABPM) in patients with symptomatic coronary heart disease (CHD) or asymptomatic coronary lesions and in patients at high coronary risk, such as in the presence of hypertension. We identified ten cross-sectional and seven prospective studies in patients with CHD or coronary lesions. ...
Amigo-Benavent Miryam - - 2013
The present research aimed to evaluate the feasibility of a soybean Bowman-Birk inhibitor (BBI) as a natural functional food ingredient. The influence of food processing, storage and digestion on the structure and bioactivity of BBI added to a food matrix was evaluated. The cytotoxic effect of the digested samples was ...
Ryan D - - 2013
We recently generated an advanced mouse model of Alzheimer's disease (AD) by targeted knock-in of single-copy mutated human amyloid precursor-protein (APP) and tau genes, crossed with a non-symptomatic presenilin (PS1A246E) over-expressing mouse line. These PLB1Triple mice presented with age-dependent and AD-relevant phenotypes. Homozygous PLB1Triple mice aged 4-12 months were assessed here ...
Kayukawa Takumi - - 2013
The red flour beetle, Tribolium castaneum, has been widely used as a laboratory model for analyzing gene function. In this study, we established a novel cell line (Tc81) from T. castaneum embryos and validated the utility of this cell line by analyzing the juvenile hormone (JH) signaling pathway. In Tc81 ...
Dua Janet - - 2013
Eccrine nevi are rare lesions characterized by a sharply demarcated area of localized hyperhidrosis. We present an 11-year-old girl with an eccrine nevus on her right lower forearm. To the best of our knowledge, this is the first case successfully controlled with topical glycopyrrolate wipes.
Scholtyssek Christine - - 2013
We investigated the formation of an abstract concept of same/different in a harbor seal by means of a two-item same/different task. Stimuli were presented on a TFT monitor. The subject was trained to respond according to whether two horizontally aligned white shapes presented on a black background were the same, ...
Ishioka Ken - - 2013
The HSV-1 VRTK(-) strain, isolated in our laboratory as an acyclovir-resistant thymidine kinase (TK)-deficient mutant, was more sensitive to type 1 interferon than was the parent strain VR3. We investigated the properties of this mutant to clarify the mechanism for its hyper-sensitivity to IFN. Our findings were as follow; 1) ...
Wong John Ct - - 2013
Dysregulation of nucleophosmin 1 (NPM1) has been found in numerous solid and hematological malignancies. Our previous meta-analysis of colorectal cancer (CRC) high throughput gene expression profiling studies identified it as a consistently reported up-regulated gene in the malignant state. Our aims were to compare NPM1 expression in normal colon, adenoma ...
Akhigbe Joshua - - 2013
Reaction of known meso-tetraarylporpholactone free bases , made from the corresponding porphyrins, with hydrazine produces three products: It converts the lactone functional group into an N-aminolactam moiety, generating porphyrin-like N-aminoporpholactams . It also reduces regioselectively the β,β'-double bond of the pyrrolic moiety opposite to the imidazolone in both the starting ...
Liu Fang - - 2013
We report a simple and low-cost strategy that allows the sequential and site-specific assembly of a dehydrogenase-based multi-enzyme cascade for methanol oxidation on the yeast surface using the high-affinity interactions between three orthogonal cohesin-dockerin pairs. The multi-enzyme cascade showed 5 times higher NADH production rate than the non-complexed enzyme mixture, ...
Gerhardt Andreas - - 2013
BACKGROUND: Physical activity (PA) is recommended for stable patients with advanced heart failure (HF). PURPOSE: We evaluated expected health benefits of PA and social support as facilitators of PA, and physical symptom distress and psychological distress (depression, anxiety) as barriers to PA. Additionally, we investigated if facilitators of PA are ...
Wu Rui - - 2013
To observe the effects of miR-125b on the differentiation of rat bone marrow mesenchymal stem cells (BMSCs) into neuron-like cells, rat BMSCs were isolated and transfected with Syn-rno-miR-125b* miScript miRNA Mimic (Mimic + BME group), with anti-rno-miR-125b* miScript miRNA Inhibitor (Inhibitor + BME group) and BME control was set up without transfection. Blank controls ...
Wang C - - 2013
The type I interferon system genes IKBKE and IFIH1 are associated with the risk of systemic lupus erythematosus (SLE). To identify the sequence variants that are able to account for the disease association, we resequenced the genes IKBKE and IFIH1. Eighty-six single-nucleotide variants (SNVs) with potentially functional effect or differences ...
Robichaud Guillaume G W. M. Keck FT-ICR Mass Spectrometry Laboratory, Department of Chemistry, North Carolina State University, Raleigh, NC 27695, - - 2013
During the past decade, the field of mass spectrometry imaging (MSI) has greatly evolved, to a point where it has now been fully integrated by most vendors as an optional or dedicated platform that can be purchased with their instruments. However, the technology is not mature and multiple research groups ...
Hinder Mark R MR Human Motor Control Laboratory, School of Psychology, University of Tasmania, Private Bag 30, Hobart, Tas, 7001, Australia. - - 2013
We recently reported considerably less inter-limb transfer in older, compared to young, adults following dominant (right) hand motor training (Hinder et al. in J Appl Physiol 110:166-175, 2011). This occurred despite the fact that both age groups exhibited similar performance improvements in the trained limb. However, asymmetries can exist with ...
Freedman R - - 2013
Medical intervention for lysosomal storage disorders becomes part of life, shaping the reality of the condition for affected individuals and families. Enzyme replacement therapy (ERT) is available to treat some lysosomal storage disorders. ERT is costly and time consuming, requiring frequent hospital visits to receive intravenous infusions. This qualitative study ...
Zhou Huanhuan - - 2013
A facile hydrothermal method was developed to synthesize nitrogen-rich phenolic microspheres with a tunable ultra-microporous structure for CO2 adsorption. The results highlighted that chemical composition and ultramicroporous size, much more than surface area, dictated the CO2 uptake in a microporous organic polymer.
Mori Reika - - 2013
Three new terpenoids, opaciniols A-C (1-3), were isolated from the barks of Garcinia opaca, together with malabarica-17,21-dien-3β,14-diol (4) and 13βH-malabarica-14,17,21-trien-3β-ol (5). Their structures were determined on the basis of NMR spectroscopic data. 3 and 4 showed moderate cytotoxicity against HL-60 cells.
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