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Results 201 - 250 of 2429
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Weidner Jessica M - - 2013
Host cell manipulation is an important feature of the obligate intracellular parasite Toxoplasma gondii. Recent reports have shown that the tachyzoite stages subvert dendritic cells (DC) as a conduit for dissemination (Trojan horse) during acute infection. To examine the cellular basis of these processes, we performed a detailed analysis of ...
Xia Xiaohua - - 2013
A number of genetic studies have established that Sox10 is a transcription factor associated with neurogenesis in vertebrates. We have isolated a homologue of Sox10 gene from the brain of Misgurnus anguillicaudatus by using homologous cloning and RACE method, designated as MaSox10b. The full-length cDNA of MaSox10b contained a 311 bp ...
Matsuda Takanori - - 2013
A formal [4 + 2] annulation occurs between 1,3-disubstituted cyclobutenols and internal alkynes in the presence of rhodium(i) catalysts to afford 1,2,3,5-tetrasubstituted benzenes. These benzannulation products are generated through dehydration of the initially formed cyclohexadienols.
Thomas S - - 2013
Most countries still do not achieve 1 IU of factor VIII/capita sufficient for survival. Although primary prophylaxis prevents synovitis, is not universally used. Chronic synovitis is treated with arthroscopy at expense of considerable amount of coagulation factors, and specialized surgeons. Radioactive synovectomy (RS) is a minimally invasive and cost effective alternative ...
Eller Cleiton B - - 2013
Foliar water uptake (FWU) is a common water acquisition mechanism for plants inhabiting temperate fog-affected ecosystems, but the prevalence and consequences of this process for the water and carbon balance of tropical cloud forest species are unknown. We performed a series of experiments under field and glasshouse conditions using a ...
Buljubasich Lisandro - - 2013
The alignment of the nuclear spins in parahydrogen can be transferred to other molecules by a homogeneously catalyzed hydrogenation reaction resulting in dramatically enhanced NMR signals. In this chapter we introduce the involved theoretical concepts by two different approaches: the well known, intuitive population approach and the more complex but ...
Kim Jung-Min - - 2013
Infection with Helicobacter pylori leads to gastritis, peptic ulcers, and gastric cancer. Moreover, the inflammatory cytokine interleukin-8 and reactive oxygen species increase in the gastric mucosa when exposed to H. pylori. Anthocyanins demonstrate anti-oxidative, antibacterial, and anti-inflammatory properties. However, the effect of anthocyanins in H. pylori-infected cells is not yet ...
Gerhardt Andreas - - 2013
BACKGROUND: Physical activity (PA) is recommended for stable patients with advanced heart failure (HF). PURPOSE: We evaluated expected health benefits of PA and social support as facilitators of PA, and physical symptom distress and psychological distress (depression, anxiety) as barriers to PA. Additionally, we investigated if facilitators of PA are ...
Wu Rui - - 2013
To observe the effects of miR-125b on the differentiation of rat bone marrow mesenchymal stem cells (BMSCs) into neuron-like cells, rat BMSCs were isolated and transfected with Syn-rno-miR-125b* miScript miRNA Mimic (Mimic + BME group), with anti-rno-miR-125b* miScript miRNA Inhibitor (Inhibitor + BME group) and BME control was set up without transfection. Blank controls ...
Wang C - - 2013
The type I interferon system genes IKBKE and IFIH1 are associated with the risk of systemic lupus erythematosus (SLE). To identify the sequence variants that are able to account for the disease association, we resequenced the genes IKBKE and IFIH1. Eighty-six single-nucleotide variants (SNVs) with potentially functional effect or differences ...
Robichaud Guillaume - - 2013
During the past decade, the field of mass spectrometry imaging (MSI) has greatly evolved, to a point where it has now been fully integrated by most vendors as an optional or dedicated platform that can be purchased with their instruments. However, the technology is not mature and multiple research groups ...
Freedman R - - 2013
Medical intervention for lysosomal storage disorders becomes part of life, shaping the reality of the condition for affected individuals and families. Enzyme replacement therapy (ERT) is available to treat some lysosomal storage disorders. ERT is costly and time consuming, requiring frequent hospital visits to receive intravenous infusions. This qualitative study ...
Fam Hok Khim - - 2013
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that processes blocked 3' ends of DNA breaks. Functional loss of Tdp1 causes spinocerebellar ataxia with axonal neuropathy type 1 (SCAN1). Based on the prominent cytoplasmic expression of Tdp1 in the neurons presumably affected in SCAN1, we hypothesized that Tdp1 participates ...
Franchi Carlotta - - 2013
PURPOSE: To compare the geographical differences in the prevalence of chronic polypharmacy in community-dwelling older people over 11 years. METHODS: This study analyzed nearly two million patients aged 65-94 years recorded in the Drug Administrative Database of the Lombardy Region (Northern Italy) from 2000 to 2010. Chronic polypharmacy was defined as taking ...
Chou Kuo-Chen - - 2013
Many molecular biosystems and biomedical systems belong to the multi-label systems in which each of their constituent molecules possesses one or more than one function or feature, and hence needs one or more than one label to indicate its attribute(s). With the avalanche of biological sequences generated in the post ...
Zhu Liang - - 2013
The combination of zero-valent iron (ZVI) with anaerobic sludge for enhancing reductive transformation and dechlorination of p-chloronitrobenzene (p-ClNB) was investigated in this study. p-ClNB was quickly reduced into p-chloroaniline (p-ClAn) and subsequently dechlorinated into aniline in the complex system, and the strengthening factor for pseudo-first-order transformation rate constant of p-ClNB ...
Bayliss M - - 2013
This paper presents a multi-method research project to develop a conceptual framework for measuring outcomes in studies of osteoporotic kyphosis. The research involved literature research and qualitative interviews among clinicians who treat patients with kyphosis and among patients with the condition. INTRODUCTION: Kyphosis due to at least one vertebral compression ...
van Liempd S - - 2013
We developed an assay for the extraction and simultaneous quantitation of five key metabolites of the methionine metabolic pathway in liver tissue. The metabolites included were 5'-methylthioadenosine, methionine, homocysteine, S-adenosyl-L-homocysteine, and S-adenosyl-L-methionine. The metabolites were extracted using a bead-based homogenization method, and quantitation was carried out using hydrophilic interaction chromatography ...
Hine Kristen - - 2013
Some have challenged Thomson's case of the famous unconscious violinist (UV) by arguing that in cases of consensual sex a woman is partially morally responsible for the existence of a needy fetus; since she is partially responsible she ought to assist the fetus, and so abortion is morally wrong. Call ...
Zhan Xuefang - - 2013
A new ionization source based on microwave induced plasma was developed for ambient desorption/ionization. The microwave-induced plasma desorption/ionization source (MIPDI) was composed of a copper Surfatron microwave cavity where a fused-silica tube was centered axially. Stable non-local thermodynamic equilibrium plasma was generated in the quartz discharge tube when a microwave ...
Sood S L - - 2013
Type 3 von Willebrand's disease (VWD) is a rare bleeding diathesis with complete or near complete deficiency of von Willebrand factor (VWF) and low factor VIII (FVIII) levels. In contrast, only FVIII is decreased in haemophilia A (HA). Both disorders are complicated by arthropathy. The purpose of this study was ...
Westbrook Jared W - - 2013
Rapidly enhancing oleoresin production in conifer stems through genomic selection and genetic engineering may increase resistance to bark beetles and terpenoid yield for liquid biofuels. We integrated association genetic and genomic prediction analyses of oleoresin flow (g 24 h(-1) ) using 4854 single nucleotide polymorphisms (SNPs) in expressed genes within a pedigreed ...
Dufrêne Yves F - - 2013
Cells are constantly exposed to mechanical stimuli in their environment and have several evolved mechanisms to sense and respond to these cues. It is becoming increasingly recognized that many cell types, from bacteria to mammalian cells, possess a diverse set of proteins to translate mechanical cues into biochemical signalling and ...
Krunic Aleksandar L - - 2013
Acral peeling skin syndrome (APSS) is a clinically and genetically heterogeneous disorder. We used whole-exome sequencing to identify the molecular basis of APSS in a consanguineous Jordanian-American pedigree. We identified a homozygous nonsense mutation (p.Lys22X) in the CSTA gene, encoding cystatin A, that was confirmed using Sanger sequencing. Cystatin A ...
Eid N - - 2013
The presence of variant intercostal and bronchial arteries and variable position of left recurrent laryngeal nerve (LRLN) along the course of thoracic duct (TD) may have clinical relevance in various cervicothoracic surgeries.
Trovato Guglielmo M - - 2013
Background: Association of methylenetetrahydrofolate reductase (MTHFR) 677C>T gene polymorphism with hyperhomocysteinemia, renal failure, and cardiovascular events is controversial. We investigated the relationship of MTHFR 677C>T polymorphisms with left ventricular hypertrophy (LVH) and renal insufficiency. Methods: Glomerular filtration rate (GFR) and left myocardial ventricular mass/m2 were assessed in 138 non-diabetic subjects ...
Kuzari D - - 2013
Breast cancer is the most common type of cancer among women. The current study uses the qualitative method to examine breast cancer patients' viewpoint regarding the doctor-patient communication and its implications during their treatment. All the women brought up the same central themes: Assuming an active attitude in their life. ...
Bickenbach K A - - 2013
PURPOSE: To examine the association between positive resection margins and survival and local recurrence in patients with gastric cancer undergoing resection with curative intent. METHODS: Patients who underwent curative intent resection for gastric carcinoma from 1985 to 2010 were identified from a prospectively maintained database. Positive margins were defined as ...
Huang Yong - - 2013
Highly sensitive detection of proteins is essential to biomedical research as well as clinical diagnosis. Here, we develped a novel label-free colorimetric aptasensor based on nicking enzyme assisted signal amplification and DNAzyme amplification for highly sensitive detection of protein. The system consists of a hairpin DNA probe carrying an aptamer ...
Bartlett John M S - - 2013
Results from the NSABP B-28 trial suggest AKT activation may predict reduced benefit from taxanes following standard anthracycline therapy. Pre-clinical data support a link between PI3 K/AKT signalling and taxane resistance. Using the UK taxotere as adjuvant chemotherapy trial (TACT), we tested the hypothesis that activation of AKT or downstream markers, ...
Montecchi M G - - 2013
Background: Posture control appears deeply impaired in patients with severe Acquired Brain Injury (ABI). One of the main goals of neurorehabilitation specialists is to try to assess this neural function in a standardized manner. However, the tests available to evaluate posture control recovery after brain damage were developed for patients ...
Birbaumer Niels - - 2013
Despite considerable growth in the field of brain-computer or brain-machine interface (BCI/BMI) research reflected in several hundred publications each year, little progress was made to enable patients in complete locked-in state (CLIS) to reliably communicate using their brain activity. Independent of the invasiveness of the BCI systems tested, no sustained ...
Arguello Blanca - - 2013
Background Medicines compendia, also called formularies, are the most commonly used drug information source among health care professionals. Objective The aim was to identify the countries publishing medicines compendia and the socio-demographic factors associated to this fact. Additionally, we sought to determine the use of foreign compendia in countries lacking ...
Flores-Méndez Marco A - - 2013
Glutamate (Glu), the major excitatory amino acid, activates a wide variety of signal transduction cascades. Synaptic plasticity relies on activity-dependent differential protein expression. Glu receptors have been critically involved in long-term synaptic changes, although recent findings suggest that Na(+)-dependent Glu transporters participate in Glu-induced signalling. Within the cerebellum, Bergmann glia ...
Hui Y - - 2013
PURPOSE:    Our purpose was to identify what surgical skills trainees consider important to possess before performing in the operating room and the components of an optimal simulator. METHODS:    An online survey composed of 35 questions was completed by 67 orthopedic residents from across Canada. The questions examined the opinions of ...
Jeff Janina M - - 2013
Electrocardiographic (ECG) measurements vary by ancestry. Genome-wide association studies (GWAS) have identified loci that contribute to ECG measurements; however, most are performed in Europeans collected from population-based cohorts or surveys. The strongest associations reported are in NOS1AP with QT interval and SCN10A with PR and QRS durations. The extent to ...
Adak Atanu - - 2013
High-altitude (HA) visitors like pilgrims, trackers, scientists and military personnel face a group of nonspecific gastrointestinal (GI) symptoms during acclimatization to hypobaric hypoxia. In order to investigate the alteration of indigenous gastrointestinal microbiota in the development of such GI symptoms, an experiment was conducted for the enumeration of dominant cultivable ...
Gao Wei - - 2013
c-Met plays an important role in colorectal tumorigenesis and disease progression and thus is believed to be an attractive inhibitory target for receptor molecular therapeutic. SU11274 was identified as a small molecule, ATP competitive inhibitor of the catalytic activity of the c-Met kinase. Our study had investigated the relationship between ...
Alarousu Erkki - - 2013
Spectral-Domain Optical Coherence Tomography (SD-OCT) is an optical method capable of 3D imaging of object's internal structure with micron-scale resolution. Modern SD-OCT tools offer the speed capable of online monitoring of printed devices. This paper demonstrates the use of SD-OCT in a simulated roll-to-roll (R2R) process through monitoring some structural ...
Dalton Rebecca L - - 2013
The objectives of this study were to compare the sensitivities of field populations and a laboratory culture of a duckweed species (Lemna minor) to the herbicide atrazine using three different endpoints and to determine whether sensitivity to atrazine was affected by past exposure to the herbicide. L. minor cultures were ...
Abe Hiroyuki - - 2013
Pulmonary tumor thrombotic microangiopathy is a rare but lethal complication in cancer-bearing patients, particularly those with gastric cancer. It is characterized by cancer cell emboli with marked intimal proliferation. In the present study, we tried to elucidate the pathogenesis of pulmonary tumor thrombotic microangiopathy, notably angiogenic factors specific for cancer ...
Nojiri Shuko - - 2013
Prevalent fractures are major contributors to an increased risk of subsequent fractures, particularly in people with osteoporosis. While many studies have been conducted to assess the incidence of fracture in Japanese people with osteoporosis, far fewer have been conducted to assess the risk of subsequent fractures. This article reviews the ...
Kilgore M L - - 2013
We conducted a cluster randomized trial testing the effectiveness of an intervention to increase the use of osteoporosis medications in high-risk patients receiving home health care. The trial did not find a significant difference in medication use in the intervention arm. INTRODUCTION: This study aims to test an evidence implementation ...
Bakhshaee Mehdi - - 2013
Allergic fungal sinusitis (AFS) is a noninvasive form of fungal rhinosinusitis with a prevalence of 6-9 % among all rhinosinusitis cases requiring surgery. The fungi causing AFRS have a great diversity and regional variation in the incidence of AFS has been reported worldwide. The aim of this study was to evaluate ...
Desai Payal C - - 2013
Introduction: Acute chest syndrome (ACS), a leading cause of morbidity and mortality in sickle cell disease (SCD), is an acute illness characterized by fever and/or respiratory symptoms, accompanied by a new pulmonary infiltrate on a chest X-ray. There is increasing knowledge regarding the etiology and pathogenesis of ACS in SCD. ...
de Moraes Marcela Cristina - - 2013
The parasite Schistosoma mansoni (Sm) depends exclusively on the salvage pathway for its purine requirements. The enzyme purine nucleoside phosphorylase (PNP) is, therefore, a promising target for development of antischistosomal agents and an assay for screening of inhibitors. To enable this, immobilized SmPNP reactors were produced. By quantification of hypoxanthine ...
Jiang Zhi Hao - - 2013
Metamaterials have the potential to create optical devices with new and diverse functionalities based on novel wave phenomena. Most practical optical systems require that the device properties be tightly controlled over a broad wavelength range. However, optical metamaterials are inherently dispersive, which limits operational bandwidths and leads to high absorption ...
Tao S-D - - 2013
HLA-C*01:02:18 shows one nucleotide difference from that of HLA-C*01:02:01 by a single nucleotide substitution at position 474 C>T in exon 3.
Taschenberger G - - 2013
Objective: While the contribution of α-Synuclein to neurodegeneration in Parkinson's disease is well accepted, the putative impact of its close homologue, β-Synuclein, is enigmatic. β-Synuclein is widely expressed throughout the central nervous system as is α-Synuclein, but the physiological functions of both proteins remain unknown. Recent findings supported the view ...
Cremer Jeannette - - 2013
OBJECTIVE: To investigate the efficacy of maxillary and infraorbital nerve blocks for prevention of cardiovascular and qualitative responses to rhinoscopy, as well as response to skin clamping after assigned nerve block placement. STUDY DESIGN: Randomized, blinded, placebo-controlled cross-over experimental study. ANIMALS: Eight random-source mixed breed dogs > 1 year old and weighing ...
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