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Bessonneau Vincent - - 2013
Background: Saliva samples collected from one 58 year old male and one 35 year old female during 7 days of fasting were analyzed by direct immersion of both C18 and mixed-mode biocompatible solid-phase microextraction fibers, in combination with a LC-MS method using a benchtop orbitrap instrument in both positive and ...
Cooke Andrew - - 2013
It is well documented that competition can affect performance and emotion in sport. However, our understanding of the comparative effects of individual and team competitions on performance and emotion is limited. We also know little about emotion-based mechanisms underlying the effects of different types of competition on performance. To address ...
Kallem Raja Reddy - - 2013
Background: A highly sensitive, specific and rapid LC-ESI-MS/MS method has been developed and validated for simultaneous quantification of amlodipine (AMD) and atenolol (ATL) in human plasma (200 µl) using AMD-d4 and ATL-d7, respectively, as an internal standard (IS) as per the regulatory guidelines. Results: The SPE method was used to ...
Arnold Rachel - - 2013
The series of related studies reported here describe the development and validation of the Organizational Stressor Indicator for Sport Performers (OSI-SP). In Study 1, an expert and usability panel examined the content validity and applicability of an initial item pool. The resultant 96 items were analyzed with exploratory factor analyses ...
McKinney Andrew R - - 2013
Background: Effective control of the use of anabolic-androgenic steroids (AASs) in animal sports is essential in order to ensure both animal welfare and integrity. In order to better police their use in Australian and New Zealand greyhound racing, thorough metabolic studies have been carried out on a range of registered ...
Pfeffer Ines - - 2013
Targeted communication about health behaviors seems to be more effective than mass communication in which undifferentiated audiences receive identical messages. Regulatory focus is psychological variable that can be used to build two target groups: promotion-focused or prevention-focused people. It is hypothesized that targeting messages to an individual's regulatory focus creates ...
Sabella Donna - - 2013
We lack balance in our current approach to mental health care.
Mudiam Mohana Krishna Reddy - - 2013
Background: The present communication describes the combination of molecularly imprinted SPE and dispersive liquid-liquid microextraction for the selective preconcentration and determination of telmisartan (TEL) in rat urine, plasma and pharmaceutical formulation by HPLC. Results: Various factors that can affect the extraction efficiency of molecularly imprinted SPE and dispersive liquid-liquid microextraction ...
Chalabaev Aïna - - 2013
Previous evidence shows that stereotype threat impairs complex motor skills through increased conscious monitoring of task performance. Given that one-step motor skills may not be susceptible to these processes, we examined whether performance on a simple strength task may be reduced under stereotype threat. Forty females and males performed maximum ...
Rosenberg Karen - - 2013
At least one mental disorder usually precedes suicidal behaviors.
Fok August Wm - - 2013
OBJECTIVES. To report the clinical and radiological results of all-inside meniscal repairs using a pre-loaded suture anchor. DESIGN. Case series. SETTING. Regional hospital, Hong Kong. PATIENTS. From January 2008 to June 2010, 51 patients with a mean age of 26 (range, 15-48) years with 57 meniscal tears underwent meniscal repair ...
Klein Margot - - 2013
The ability to handle a complex medication regimen is important for patients with cancer being treated on an outpatient basis, because many of them have to take drugs for oral chemotherapy, against cancer-related symptoms, side effects of the treatments, and preexisting conditions. This qualitative study examined how patients experienced a ...
Potera Carol - - 2013
Checklists reduce the failure rate of lifesaving procedures during operating room crises.
Guo Xiang Yu - - 2013
To study the use of traditional Chinese medicine (TCM) or both TCM and guideline-recommended Western medicine (WM) in Chinese patients with coronary heart disease (CHD). A cross-sectional nationwide survey of 2803 CHD outpatients was completed by collecting information, including general demographic data, disease history, and use of drugs (including TCM ...
Duncan S D - - 2013
Baclofen is a gamma-aminobutyric acid agonist used primarily as a muscle relaxant to treat spasticity in children and adults. Withdrawal of oral baclofen is known to cause a withdrawal syndrome in adults. Only one previous case describes a withdrawal syndrome in a term infant, manifested by seizures, associated with the ...
Jones James W - - 2013
The chief of surgery at a large academic medical center is approached by a vascular surgical faculty member. After a repair of an aortic dissection, an elderly man has remained comatose and has worsened over several weeks, developing multiple system organ failure. Statistically, his chance of leaving the hospital alive ...
Wegwarth Odette - - 2013
In most psychological and medical research, patients are assumed to have difficulties with health statistics but clinicians not. However, studies indicate that most doctors have problems in understanding health statistics, including those of their own speciality. For example, only two out of 20 urologists knew the information relevant for a ...
Goodman Diane - - 2013
An NP with a history of falls argues that we can do better.
Prendergast Caitlin - - 2013
Respiratory syncytial virus (RSV) is the most important cause of infantile bronchiolitis and pneumonia. It is ubiquitous, with most children acquiring their primary infection within the first year of life and with subsequent reinfection occurring in all age groups. Clinically, RSV is virtually indistinguishable from other viral respiratory infections. Traditionally, ...
Kasenda Benjamin - - 2013
Lung cancer is a leading cause of death worldwide. Patients are usually diagnosed at an advanced stage and have a very poor prognosis. In Switzerland, lung cancer is the most frequent cause of cancer death in men and the second most frequent cause of cancer death in women. Programmes to ...
Yuan Xuan - - 2013
Isoliquiritigenin (ISL), a licorice chalconoid, is considered to be a bioactive agent with chemopreventive potential. This study investigates the mechanisms involved in ISL-induced apoptosis in human cervical carcinoma HeLa cells. Cell viability was evaluated using a 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay. Apoptosis was determined by flow cytometry using an ...
García-Álvarez Lara - - 2013
There are many conventional microbiological methods in routine clinical practice to determine the sensitivity of common bacteria. The problem with these methods arises with bacteria that do not grow on habitual media (Rickettsia spp., Coxiella spp. and Anaplasma spp., among others) and for which there are no standardized techniques to ...
Chan Winnie Ky - - 2013
Vascular calcification in children with long-standing dialysis is a unique phenomenon. Hyperphosphataemia and hyperparathyroidism are the major pathogenic risk factors. We describe a young patient with end-stage renal disease diagnosed since childhood and underwent prolonged dialysis therapy. He was admitted for recurrent episodes of acute joint pain. Investigations confirmed diffuse ...
Yeung Jessie Th - - 2013
We describe a 50-year-old man who first presented with multiple skin lesions which were characteristic of Degos' syndrome. The patient developed multiple episodes of abdominal pain. Some episodes resolved with conservative management, for others he underwent urgent operations for bowel perforations. The patient subsequently underwent extensive small bowel resection, but ...
Kalkan Gokhan - - 2013
Nasopharyngeal encephalocele is a rare, benign congenital anomaly. It has the potential to be fatal due to airway obstruction. Here, we report on a 34-day-old infant with pneumonia who underwent mechanical ventilation. An upper airway evaluation was performed due to prolonged intubation, and revealed the presence of a nasopharyngeal encephalocele. ...
Li Yadi - - 2013
Synthetic drugs such as allopurinol and benzbromarone are commonly used to treat the complex pathogenesis of gout, a metabolic disease that results from an inflammation of the joints caused by precipitation of uric acid. We seek to discover novel phytochemicals that could treat gout, by targeting the xanthine oxidase and ...
Huang Ching-Ying - - 2013
Lysostaphin (LYS) is an anti-staphylococcal prokaryotic polypeptide that has been used to avoid Staphylococcus aureus mastitis through transgenic or viral vector approaches exogenously expressed in dairy animals. However, glycosylation of lysostaphin expressed in mammalian cells results in a loss of bioactivity. Until now, the mechanism of site-specific glycosylation of lysostaphin ...
Koch Klaus - - 2013
Prostate cancer screening has been a controversial for decades. The recently published findings of large trials have further intensified the debate. The prospect of reducing mortality from prostate cancer is measured against the risk of over-diagnosing the disease. In individual cases, the trade-off between possible benefits and harms is possible ...
Jacobson Joy - - 2013
Racial and ethnic health disparities persist, but nursing is providing several solutions.
Jain Manish - - 2013
Anti-platelet therapy is a useful strategy to prevent acute thromboembolic artery occlusions. This study was designed to assess the efficacy of seselin derivatives against murine pulmonary thromboembolism, bleeding time, platelet activation and thrombosis. Administration of C3 (16 mg/kg) offered 70% protection against collagen- and epinephrine-induced pulmonary thromboembolism and 30% protection against ...
Ho Mary - - 2013
OBJECTIVE. To describe the clinicopathological characteristics of patients with eyelid tumours in Hong Kong. DESIGN. Retrospective case series. SETTING. A tertiary eye centre in Hong Kong. PATIENTS. A computerised retrieval system was used to identify all patients who underwent eyelid mass excisions with histological reports, encountered in the period 2000 ...
Reimer M Todd - - 2013
Background: Biodistribution of drug and drug candidates offers critical information regarding drug disposition in target and nontarget tissues. Concentrations of therapeutic agents in target tissue provide the foundation for efficacy, while concentrations in nontarget tissue pose potential safety risks. Analysis of tissue samples can sometimes provide important information during the ...
Davis Louise - - 2013
The aim of the current study was to examine actor and partner effects of (a) athletes' and coaches' attachment styles (avoidant and anxious) on the quality of the coach-athlete relationship, and (b) athletes' and coaches' quality of the coach-athlete relationship on relationship satisfaction employing the actor-partner interdependence model (Kenny, Kashy, ...
Pengpeng Wang - - 2013
In the rumen bacteria, ammonia as the end product of nitrogen is incorporated into carbon skeleton (α-ketoglutarate) to yield glutamine and glutamate which are important nitrogen donors in nitrogenous compounds metabolism in cells. The enzymes glutamine synthetase, glutamate synthetase, and glutamate dehydrogenase are involved in these processes. Some experimental results ...
Zwahlen Marcel - - 2013
Breast cancer screening using mammography is one of the few screening interventions that have been assessed in several large randomized controlled studies (RCTs). Results from eight RCTs are available and have been summarized in several systematic reviews and meta-analyses, most of which conclude that mammography screening achieve a relative reduction ...
Anderko Laura - - 2013
Nurses advocate sustainable design to transform health care.
Major Katherine - - 2013
Offering nurses a framework for discussing-and resolving- incidents of lateral violence.This is the second article in a series on leadership, coordinated by the American Organization of Nurse Executives (AONE), highlighting how nurses are leading change efforts in hospitals. It describes work done in conjunction with the AONE's Care Innovation and ...
Lipworth Brian - - 2013
To review the available methods of evaluating the small airways disease in asthma and the therapeutic strategies to achieve better control using emerging extrafine particle inhaler technologies. The PubMed, MEDLINE (Ebsco), Scirus, Scopus, and Google Scholar databases were all scanned with Cross-search using the following keywords: asthma, small airways, hydrofluoroalkane ...
Beach Ann Fleming AF Children's Healthcare of Atlanta, Scottish Rite, USA. - - 2013
A pediatrician pays tribute to her mother's career.
Sathish Jean G JG MRC Centre for Drug Safety Science and Institute of Translational Medicine, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GE, - - 2013
Immunomodulatory biologics, which render their therapeutic effects by modulating or harnessing immune responses, have proven their therapeutic utility in several complex conditions including cancer and autoimmune diseases. However, unwanted adverse reactions--including serious infections, malignancy, cytokine release syndrome, anaphylaxis and hypersensitivity as well as immunogenicity--pose a challenge to the development of ...
Burton Hilary H PHG Foundation (Foundation for Genomics and Population Health), Cambridge, UK. - - 2013
The PHG Foundation led a multidisciplinary program, which used results from COGS research identifying genetic variants associated with breast, ovarian and prostate cancers to model risk-stratified prevention for breast and prostate cancers. Implementing such strategies would require attention to the use and storage of genetic information, the development of risk ...
Li Rui R Purdue University, Weldon School of Biomedical Engineering, West Lafayette, Indiana 47907, - - 2013
Photoacoustic imaging employing molecular overtone vibration as a contrast mechanism opens a new avenue for bond-selective imaging of deep tissues. Broad use of this modality is, however, hampered by the extremely low conversion efficiency of optical parametric oscillators at the overtone transition wavelengths. To overcome such a barrier, we demonstrate ...
Ahmed Nafees N Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Mohali, Punjab 160062, - - 2013
Fifty analogues of batzelladine K were synthesized and evaluated for in vitro antimalarial (Plasmodium falciparum), antileishmanial (Leishmania donovani), antimicrobial (panel of bacteria and fungi), antiviral (HIV-1) activities. Analogues 14h and 20l exhibited potential antimalarial activity against chloroquine-sensitive D6 strain with IC(50) 1.25 and 0.88 μM and chloroquine-resistant W2 strain with ...
Michailidou Kyriaki K Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, - - 2013
Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer ...
Garcia-Closas Montserrat M 1] Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK. [2] Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK. - - 2013
Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci ...
Chen Jiang-Fan JF Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, - - 2013
Adenosine signalling has long been a target for drug development, with adenosine itself or its derivatives being used clinically since the 1940s. In addition, methylxanthines such as caffeine have profound biological effects as antagonists at adenosine receptors. Moreover, drugs such as dipyridamole and methotrexate act by enhancing the activation of ...
Codd Veryan V Department of Cardiovascular Sciences, University of Leicester, Leicester, - - 2013
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer and several age-associated diseases. We report here a genome-wide meta-analysis of 37,684 individuals with replication of selected variants in an additional 10,739 individuals. We identified seven loci, including five new loci, associated with mean LTL (P < 5 ...
Dejea Christine C Department of Molecular Microbiology & Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, - - 2013
The human colon plays host to a diverse and metabolically complex community of microorganisms. While the colonic microbiome has been suggested to contribute to the development of colorectal cancer (CRC), a definitive link has not been made. The role in which the colon microflora could contribute to the initiation and/or ...
Pharoah Paul D P PD The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. - - 2013
Genome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled data from a GWAS conducted in North America with another GWAS from the UK. We selected the top 24,551 SNPs for inclusion on the iCOGS ...
Bojesen Stig E SE Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark. - - 2013
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte ...
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