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Westercamp Nelli N Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, 1603 W. Taylor St., MC 923, Chicago, IL, 60612, USA, - - 2013
Our objectives were to: (1) compare multiple measures of partnership concurrency, including the UNAIDS-recommended definition and (2) describe the prevalence and correlates of concurrent sexual partnerships among young Kenyan men. We analyzed 10,907 lifetime partnerships of 1,368 men ages 18-24 years enrolled in a randomized trial of male circumcision to ...
Mathys Christian C Department of Diagnostic and Interventional Radiology, University Düsseldorf, Medical Faculty, Düsseldorf, - - 2013
We investigated the utility of diffusion tensor imaging (DTI) for detecting neuropathic changes in proximal nerve segments in patients with peripheral neuropathy. Twenty-one individuals with (n = 11) and without (n = 10) peripheral neuropathy underwent DTI of a defined sciatic nerve segment. Patients and controls were evaluated by clinical ...
Evenson Kelly R KR 1Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, NC; 2Center for Health Promotion and Disease Prevention, University of North Carolina-Chapel Hill, Chapel Hill, NC; 3Department of City and Regional Planning, University of Pennsylvania, Philadelphia, PA; and 4RAND Corporation, Santa Monica, - - 2013
Parks offer a free option for physical activity in many communities. How much time people spend using parks and the contribution that parks makes to their physical activity is not known. This study describes patterns of park use and physical activity among a diverse adult sample. From five US states, ...
Bertola Adeline A Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, - - 2013
Chronic plus binge ethanol feeding acts synergistically to induce liver injury in mice, but the mechanisms underlying this phenomenon remain unclear. Here, we show that chronic plus binge ethanol feeding synergistically up-regulated the hepatic expression of interleukin-1β and tumor necrosis factor alpha and induced neutrophil accumulation in the liver, compared ...
Benítez Carlos C Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBEREHD, University of Barcelona, Barcelona, - - 2013
Lifelong immunosuppression increases morbidity and mortality in liver transplantation. Discontinuation of immunosuppressive drugs could lessen this burden, but the safety, applicability, and clinical outcomes of this strategy need to be carefully defined. We enrolled 102 stable liver recipients at least 3 years after transplantation in a single-arm multicenter immunosuppression withdrawal ...
Hart Emma C EC Department of Anesthesiology, Mayo Clinic, Rochester, MN, - - 2013
Aortic wave reflection characteristics, such as augmentation index, are positively related to muscle sympathetic nerve activity in young men. In young women, there is an inverse relationship. We investigated whether this inverse relationship persisted in postmenopausal women. Muscle sympathetic nerve activity (peroneal microneurography) and arterial pressure (brachial catheter) were measured ...
Lambiase Maya J MJ Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. - - 2013
Few studies have examined the relationship between physical activity and sleep among women with vasomotor symptoms. We examined the associations of habitual leisure time and household physical activity with sleep characteristics among women reporting vasomotor symptoms. A subcohort of women (N = 52: white, 27; African American, 25) in the ...
Mori Kyoko K Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, - - 2013
Ribavirin (RBV) is often used in conjunction with interferon-based therapy for patients with chronic hepatitis C. There is a drastic difference in the anti-hepatitis C virus (HCV) activity of RBV between the HuH-7-derived assay system, OR6, possessing the RBV-resistant phenotype (50% effective concentration [EC50 ]: >100 µM) and the recently ...
Fettiplace Michael R MR University of Illinois College of Medicine, Chicago, IL, USA. - - 2013
Bolus infusion of lipid emulsion can reverse cardiac pharmacotoxicity caused by local anesthetics and other lipophilic drugs. The mechanisms of this effect are not completely elucidated. The authors test the hypothesis that lipid emulsion infusion exerts direct, positive inotropic effects. Prospective, randomized animal study. University research laboratory. Adult male Sprague-Dawley ...
Tedesco Tamara Kerber TK Department of Orthodontics and Pediatric, University of Sao Paulo, Sao Paulo, - - 2013
To evaluate an alternative device using starch tubes to build up resin composite specimens for microshear bond tests. Twenty human molars were selected and sectioned mesiodistally to obtain two sections. The teeth were randomly divided into 4 groups (n = 10) according to the adhesive system - a two-step etch-and-rinse ...
Crago Aimeé M AM Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. - - 2013
To construct a postoperative nomogram to estimate the risk of local recurrence for patients with desmoid tumors. The standard management of desmoid tumors is resection, but many recur locally. Other options include observation or novel chemotherapeutics, but little guidance exists on selecting treatment. Patients undergoing resection during 1982-2011 for primary ...
Diaz-Ledezma Claudio C The Rothman Institute of Orthopaedics at Thomas Jefferson University Hospital, Sheridan Building, 125 South 9th Street, Philadelphia, PA 19107, - - 2013
Currently, three surgical approaches are available for the treatment of cam femoroacetabular impingement (FAI), namely surgical hip dislocation (SHD), hip arthroscopy (HA), and the miniopen anterior approach of the hip (MO). Although previous systematic reviews have compared these different approaches, an overall assessment of their performance is not available. We ...
DiMagno Matthew J MJ Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA. - - 2013
We investigated which variables independently associated with protection against or development of postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) and severity of PEP. Subsequently, we derived predictive risk models for PEP. In a case-control design, 6505 patients had 8264 ERCPs, 211 patients had PEP, and 22 patients had severe PEP. We ...
Hsu Shu-hao SH Department of Molecular & Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, - - 2013
We have previously reported that the gene encoding protein tyrosine phosphatase receptor type-O (PTPRO) is suppressed by promoter methylation in a rat model of hepatocellular carcinoma (HCC) and it functions as tumor suppressor in leukemia and lung cancer. Here, we explored the methylation and expression of PTPRO as well as ...
Herraez Elisa E Laboratory of Experimental Hepatology and Drug Targeting (HEVEFARM), Biomedical Research Institute of Salamanca (IBSAL), University of Salamanca, Salamanca, - - 2013
Reduced drug uptake is an important mechanism of chemoresistance. Down-regulation of SLC22A1 encoding the organic cation transporter-1 (OCT1) may affect the response of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CGC) to sorafenib, a cationic drug. Here we investigated whether SLC22A1 variants may contribute to sorafenib chemoresistance. Complete sequencing and selective variant ...
Gailhouste Luc L Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, - - 2013
MicroRNAs (miRNAs) are evolutionary conserved small RNAs that post-transcriptionally regulate the expression of target genes. To date, the role of miRNAs in liver development is not fully understood. By using an experimental model that allows the induced and controlled differentiation of mouse fetal hepatoblasts (MFHs) into mature hepatocytes, we identified ...
Poupon Raoul R UPMC Univ Paris 06, INSERM, UMR_S 938, Paris, France; INSERM, U938, Centre de Recherche Saint-Antoine, Paris, France. - - 2013
The low-phospholipid-associated cholelithiasis syndrome (LPAC; OMIM 171060) is a peculiar form of intrahepatic cholelithiasis occurring in young adults, associated with ABCB4/MDR3 gene sequence variations. Our aim was to determine the genotype-phenotype relationships in 156 consecutive patients with the criteria of LPAC syndrome. A variant was detected in 79 (61 missense ...
Ashraf Shirin S Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, - - 2013
CD8+ T-cell responses to hepatitis C virus (HCV) are important in generating a successful immune response and spontaneously clearing infection. Human leukocyte antigen (HLA) class I presents viral peptides to CD8+ T cells to permit detection of infected cells, and tapasin is an important component of the peptide loading complex ...
Kawata Kazuhito K Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA, - - 2013
There are several murine models described with features similar to human primary biliary cirrhosis (PBC). Among these models, the one which has the closest serologic features to PBC is a mouse with a T-cell-restricted expression of the dominant negative transforming growth factor β receptor type II (dnTGFβRII). Our work has ...
Wang Jiayi J Department of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, - - 2013
Yes-associated protein (YAP), the downstream effecter of the Hippo-signaling pathway as well as cyclic adenosine monophosphate response element-binding protein (CREB), has been linked to hepatocarcinogenesis. However, little is known about whether and how YAP and CREB interact with each other. In this study, we found that YAP-CREB interaction is critical ...
Silva Luiz Fernando Almeida LF Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, Rio Grande do Sul, - - 2013
Traumatic brain injury (TBI) is a major cause of acquired epilepsy, and significant resources are required to develop a better understanding of the pathologic mechanism as targets for potential therapies. Thus, we decided to investigate whether physical exercise after fluid percussion injury (FPI) protects from oxidative and neurochemical alterations as ...
Patterson Nicolle L NL San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, - - 2013
The left ventricle (LV) responds to a myocardial infarction with an orchestrated sequence of events that result in fundamental changes to both the structure and function of the myocardium. This collection of responses is termed as LV remodeling. Myocardial ischemia resulting in necrosis is the initiating event that culminates in ...
Gironacci Mariela M - - 2013
Ang-(1-7) [angiotensin-(1-7)] constitutes an important functional end-product of the RAS (renin-angiotensin system) endogenously formed from AngI (angiotensin I) or AngII (angiotensin II) through the catalytic activity of ACE2 (angiotensin-converting enzyme 2), prolyl carboxypeptidase, neutral endopeptidase or other endopeptidases. Ang-(1-7) lacks the pressor, dipsogenic or stimulatory effect on aldosterone release characteristic ...
Mallela Jaya J Department of Molecular Medicine, University of South Florida, Tampa, FL, - - 2013
Natriuretic peptide receptor A (NPRA), the signaling receptor for the cardiac hormone, atrial natriuretic peptide (ANP), is expressed abundantly in inflamed/injured tissues and tumors. NPRA deficiency substantially decreases tissue inflammation and inhibits tumor growth. However, the precise mechanism of NPRA function and whether it links inflammation and tumorigenesis remains unknown. ...
Dumas Jerald E JE Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 315 Ferst Dr. Suite 1308, Atlanta, GA 30332, - - 2013
Cysteine cathepsins are a family of proteases identified in cancer, atherosclerosis, osteoporosis, arthritis, and a number of other diseases. As this number continues to rise, so does the need for low cost, broad use quantitative assays to detect their activity and can be translated to the clinic in the hospital ...
Gokhale Ameya A Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, - - 2013
Targeting co-stimulatory molecules to modulate the immune response has been shown to have useful therapeutic effects for autoimmune diseases. Among the co-stimulatory molecules, CD2 and CD58 are very important in the early stages of generation of an immune response. Our goal was to utilize CD2-derived peptides to modulate protein-protein interactions ...
Eisenhauer Philip P Department of Medicine, University of Vermont College of Medicine, Burlington, VT, - - 2013
Using a model of postpneumonectomy (PNY) compensatory lung growth in mice, we previously observed an increase in numbers of a putative endogenous distal airway progenitor cell population (CCSP(pos) /pro-SPC(pos) cells located at bronchoalveolar duct junctions [BADJs]), at 3, 7, and 14 days after pneumonectomy, returning to baseline at 28 days ...
Kurinami Hitomi H Division of Vascular Medicine and Epigenetics, Department of Child Development, United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Suita, - - 2013
Because growing evidence suggests that angiotensin II receptor blockers (ARBs) effectively inhibit oxidative stress, amyloid beta protein (Aβ) metabolism, and tau phosphorylation in animal brains, ARBs are considered to be a potential candidate for the treatment of Alzheimer's disease (AD). Consistent with such basic studies, two recent observational studies and ...
Richardson Kyle S KS Montana Tech of the University of Montana, Butte, MT, USA. - - 2013
The most common mechanism for human exposure to hantaviruses throughout North America is inhalation of virally contaminated particulates. However, risk factors associated with exposure to particulates potentially contaminated with hantaviruses are generally not well understood. In North America, Sin Nombre virus (SNV) is the most common hantavirus that infects humans, ...
Nordin Catharina C Dept. of Health Science, Luleå University of Technology, 97187 Luleå, Sweden. - - 2013
To explore primary healthcare patients' experiences of patients participation in multimodal pain rehabilitation. A total of 17 patients who had completed multimodal rehabilitation for persistent pain were interviewed. The interviews were analysed using qualitative content analysis. One theme, Being in an exchange process, and 4 categories emerged. The theme depicted ...
Boyce Alison M AM Bone Health Program, Division of Orthopaedics and Sports Medicine, Children's National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA. - - 2013
Fibrous dysplasia (FD) is a skeletal disorder caused by activating mutations in Gsα that result in elevations in cAMP. A feature of FD is elevated blood levels of the bone cell-derived phosphaturic hormone, fibroblast growth factor-23 (FGF23). FGF23 regulates serum phosphorus and active vitamin D levels by action on proximal ...
Amuedo-Dorantes Catalina C Department of Economics, San Diego State University, San Diego, CA 92182, USA. - - 2013
The recent impetus of tougher immigration-related measures passed at the state level raises concerns about the impact of such measures on the migration experience, trajectory, and future plans of unauthorized immigrants. In a recent and unique survey of Mexican unauthorized immigrants interviewed upon their voluntary return or deportation to Mexico, ...
McGeachie Michael J MJ Department of Medicine, Channing Division of Network Medicine, Brigham and Women’s Hospital, 181 Longwood Ave, Boston, MA 02115, USA. - - 2013
Although accurate measures of heritability are required to understand the pharmacogenetic basis of drug treatment response, these are generally not available, as it is unfeasible to give medications to individuals for which treatment is not indicated. Using a polygenic linear mixed modeling approach, we estimated lower bounds on the heritability ...
O'Dell Michael W MW Department of Rehabilitation Medicine, Weill Cornell Medical Center, 10065 New York, USA. - - 2013
To further examine the psychometric properties of a 9-item version of the Arm Motor Ability Test (AMAT-9) in persons with stroke. Thirty-two community-dwelling persons > 6 months post-stroke undergoing robotics treatment (mean age = 56.0 years, time post-stroke = 4.1 years, National Institutes of Health Stroke Scale score = 4.1, and AMAT-9 score = 1.22). Construct validity (including Rasch ...
Groenefeld Bastian B Department of Pediatric Orthopaedics, University of Goettingen, Robert-Koch-Strasse 40, Goettingen, - - 2013
Retrospective analysis of 1328 spinal radiographs of 57 patients after vertical expandable prosthetic titanium rib (VEPTR) implantation with an average follow-up of 30 months. To evaluate the incidence, time of onset, as well as the underlying factors influencing the occurrence of ossifications in children treated with VEPTR. Spontaneous spinal fusions ...
Park Jin Hoon JH Department of Neurological Surgery, Gangneung Asan Hospital, University of Ulsan College of Medicine, Seoul, - - 2013
Retrospective review of medical records. To describe pre- and postoperative ambulatory status and lower limb motor power, and compare characteristics of patients with metastatic spinal cord compression (MSCC) who were ambulatory at 48 hours postoperatively with those of patients with MSCC who were nonambulatory. Preoperative motor power of the lower ...
Murray Susan E SE Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA. - - 2013
B cells are efficient APCs when they internalize antigen via BCR-mediated uptake. Adoptively transferred antigen-presenting B cells can induce T-cell tolerance to foreign and self antigens; however, it is unknown whether endogenous B cells presenting self-peptides interact with naïve T cells and contribute to peripheral T-cell self-tolerance. Moreover, the relative ...
Kwon Dae Gyu - - 2013
The aim of this retrospective study was to determine the short-term effects of proximal femoral derotation osteotomy (FDO) on gait in 53 ambulatory patients with spastic diplegia controlling all confounding procedures. All patients showed a jump gait pattern and had undergone bilateral rectus femoris transfer, distal hamstring lengthening, and tendo-Achilles ...
Kang Zhitao - - 2013
A glass wafer that contains cerium-activated gadolinium-based scintillator has been tested as a nuclear radiation monitor. The detector is prepared by mixing powdered gadolinium and cerium (3+) bromides with alumina, silica, and lithium fluoride, melting the mixture at 1,400°C, and then quenching and annealing the glass. The resulting clear glass ...
Belafsky Sheri - - 2013
This review addresses five key questions regarding respirator clearance: What is the efficacy of different methods of respirator clearance? Which diagnostic test is most predictive of cardiac event during respirator use? Is spirometry accurate in predicting respiratory distress/insufficiency during respirator use? Is exercise tolerance testing accurate in predicting cardiac injury ...
Pallanti Stefano - - 2013
The clinical relevance of anxiety disorders in schizophrenia has been neglected for a long time and has only recently become the subject of a systematic investigation, although its consequences may have a very negative impact on the outcome and considerably worsen the trajectory of the disease. This could be originally ...
Kim Dong Wook - - 2013
The authors assessed the radiation-induced cancer risk due to organ doses from kilovoltage (kV) cone beam computed tomography (CBCT), a verification technique in image-guided radiotherapy (IGRT). CBCTs were performed for three different treatment sites: the head and neck, chest, and pelvis. Using a glass dosimeter, primary doses versus depth were ...
Gültekin Salih Sinan - - 2013
The authors investigated the efficacy of the patient-dependent practices (micturition, defecation, and taking a shower) after I ablation therapy in patients with thyroid cancer. Exposure rates were measured from a 1-m distance at 2, 4, and 24 h after the I administration. The comparisons for 2-4 h and 2-24 h ...
McKenna T - - 2013
Experience and studies show that for an emergency at a nuclear power plant involving severe core damage or damage to the fuel in spent fuel pools, the following actions may need to be taken in order to prevent severe deterministic health effects and reduce stochastic health effects: (1) precautionary protective ...
Tolstykh E I - - 2013
Radioactive contamination of the Techa River (Southern Urals, Russia) occurred from 1949-1956 due to routine and accidental releases of liquid radioactive wastes from the Mayak Production Association. The long-lived radionuclides in the releases were Sr and Cs. Contamination of the components of the Techa River system resulted in chronic external ...
Daniels Jeffrey I - - 2013
The Project Rulison underground nuclear test was a proof-of-concept experiment that was conducted under the Plowshare Program in 1969 in the Williams Fork Formation of the Piceance Basin in west-central Colorado. Today, commercial production of natural gas is possible from low permeability, natural gas bearing formations like that of the ...
H Currier Blake - - 2013
Monte Carlo simulation techniques using a Monte Carlo N-Particle code (MCNP5) analyzed six Source Production & Equipment Co., Inc., Se industrial radiography sources to determine an appropriate air kerma rate constant for Se, factoring in source encapsulation and compared to a theoretical approximation. Based on this study, an air kerma ...
Huang Che-Nan - - 2013
Calcaneal lengthening is a popular surgical treatment for pronated foot deformity. The aim of this study is to assess the effectiveness of medial column stabilization in improving the results of calcaneal lengthening for pronated foot deformity in ambulatory children with cerebral palsy. Twenty-one consecutive (37 feet) children with cerebral palsy ...
Barbosa Raquel H - - 2013
To identify constitutional alterations of the retinoblastoma 1 gene (RB1) in two cohorts of Brazilian patients with retinoblastoma and to analyze genotype-phenotype associations. Molecular screening was carried out by direct sequencing of the 27 RB1 exons and flanking regions in blood DNA of 71 patients with retinoblastoma and 4 relatives ...
Sugita Sunao - - 2013
To determine whether retinal pigment epithelial (RPE) cells can inhibit mature dendritic cells (mDCs). Cultured RPE cells were established from C57BL/6 mice. DCs were established from bone marrow cells of normal mice, and mDCc were induced by culture in medium containing granulocyte macrophage-colony-stimulating factor (GM-CSF) and IL-4 in the presence ...
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