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Kwon Soonho - - 2013
: Provide treatment guidelines for glucocorticoid-induced hyperglycemia and to understand the clinical implications of glucocorticoid-induced hyperglycemia. : The authors analyzed an electronic search (Medline) and a literature review of the pertinent articles published from 1980 to September 2012. : In patients treated with glucocorticoids, the odds ratio for development of ...
Wang Jiamin - - 2013
Protein tyrosine phosphatase alpha (PTPα) functions as an activator of Src by dephosphorylating Tyr527/530, a critical negative regulatory site. The increase of PTPα catalytic activity requires its phosphorylation at Ser180 and/or Ser204 and its dissociation from PTPα/Grb2 complex. Here, we show that epidermal growth factor (EGF) stimulation increases the ability ...
Torres Bryan T BT Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, - - 2013
To compare overground and treadmill-based gaits of dogs. 5 clinically normal adult mixed-breed dogs. To obtain dynamic gait data, 30 retroreflective markers were affixed bilaterally to specific regions of the hind limbs and pelvis of each dog. For each dog, 3-D joint motion data (sagittal [flexion and extension], transverse [internal ...
Sreekumar Parameswaran G PG Arnold and Mabel Beckman Macular Research Center, Doheny Eye Institute, Los Angeles, California, - - 2013
The chaperone proteins, α-crystallins, also possess antiapoptotic properties. The purpose of the present study was to investigate whether 19 to 20-mer α-crystallin-derived mini-chaperone peptides (α-crystallin mini-chaperone) are antiapoptotic, and to identify their putative transporters in human fetal RPE (hfRPE) cells. Cell death and caspase-3 activation induced by oxidative stress were ...
Sarkars Ruma - - 2013
Heat shock proteins (HSPs) are chaperones for several client proteins involved in transcriptional regulation, signal transduction, and cell cycle control. HSPs (27, 70, and 90) are abundantly expressed in a wide range of cancers and are transcriptionally regulated by heat shock factor (HSF1). Most of the synthetic HSP inhibitors exhibit ...
Kim Sarang - - 2013
Background: Graduating medical students have reported concern regarding inadequate training in pharmacotherapy. Teaching by clinical pharmacists may improve medical students' pharmacotherapy knowledge. Purpose: To assess the impact of pharmacist led workshops on 4th year medical students' knowledge of pharmacotherapy and satisfaction. Methods: Senior medical students enrolled in intensive care unit ...
Probst Curtis W - - 2013
Objective-To evaluate the pharmacokinetics of diazepam administered per rectum via compounded (ie, not commercially available) suppositories and determine whether a dose of 2 mg/kg in this formulation would result in plasma concentrations shown to be effective for control of status epilepticus or cluster seizures (ie, 150 to 300 ng/mL) in ...
Wenner Peter - - 2013
Endocannabinoid signaling typically mediates a form of synaptic plasticity in which a postsynaptic cell acts retrogradely to reduce vesicle release from presynaptic terminals impinging on that cell. In the embryonic spinal cord, endocannabinoids inhibit spontaneously released glutamatergic vesicles in both a brief and ongoing tonic manner. Together these endocannabinoid-mediated forms ...
Loss M - - 2013
The blatant problem of organ shortage leads to an increasing acceptance of organs from extended criteria donors. This increases the importance of the process of organ donation and retrieval. A working group of representatives of Bavarian retrieval surgeons and the procurement organization German Foundation of Organ Transplantation (DSO) was initiated ...
Wolf Andrea - - 2013
The hypothalamus is a key integrative center in the brain that consists of diverse cell types required for a variety of functions including homeostasis, reproduction, stress response, social and cognitive behavior. Despite our knowledge of several transcription factors crucial for hypothalamic development, it is not known how the wide diversity ...
Daly Melissa - - 2013
Aging leads to a decline in strength and an associated loss of independence. The authors examined changes in muscle volume, maximum isometric joint moment, functional strength, and 1-repetition maximum (1RM) after resistance training (RT) in the upper extremity of older adults. They evaluated isometric joint moment and muscle volume as ...
Lowcock Elizabeth C - - 2013
Associations between caffeine and coffee consumption and breast cancer risk are uncertain, with studies suggesting inverse and null associations. Variation in cytochrome P450 1A2 (CYP1A2), a gene responsible for caffeine metabolism, may modify these associations. Cases (n = 3,062) were recruited through the Ontario Cancer Registry and controls (n = ...
Queiroz José Renato JR Department of of Prosthodontics and Dental Materials, Sao Paulo State University, Sao Jose dos Campos, - - 2013
To compare the effect of silica (Si)-based nano-coating deposited by reactive magnetron sputtering (RMP) with that of conventional surface conditioning using metal/zirconia primer alone or after air-particle abrasion on the adhesion of resin cements to zirconia ceramic. Two hundred forty zirconia ceramic blocks (Cercon) were sintered, finished with 1200- grit ...
Lewis Katherine - - 2013
: Transition of care from a child-centered care environment to an adult-centered care environment for pediatric patients with diabetes is needed to ensure continued diabetes care. The transition process should start early and be tailored to the developmental stage of the patient. The typical challenges of adolescence and young adulthood ...
Stahelin Robert V - - 2013
Surface plasmon resonance (SPR) is a powerful technique for monitoring the affinity and selectivity of biomolecular interactions. SPR allows for analysis of association and dissociation rate constants and modeling of biomolecular interaction kinetics, as well as for equilibrium binding analysis and ligand specificity studies. SPR has received much use and ...
Heidari Khosrow - - 2013
: Diabetes is a serious disease, which is often accompanied by complications, such as blindness, kidney failure, heart attacks, strokes and amputations. High blood pressure and abnormal cholesterol levels are frequent comorbidities. Diabetes has an immense impact on public health and medical care. In South Carolina (SC), medical costs rise ...
Chen Xiaochen - - 2013
To present our experience with 18 cases of well-differentiated papillary mesothelioma (WDPM), with an emphasis on its relationship to adenomatoid tumour and multicystic mesothelioma. Eighteen cases of WDPM were retrieved. Twenty cases of multicystic mesothelioma were selected for comparative study. The WDPM patients comprised 14 females and four males, with ...
Lanfranchi Joy A - - 2013
A code blue in the OR is a low-volume, high-risk event. To be effective during a code blue event, perioperative personnel must be able to properly execute a response plan and perform seldom-used skills and procedures. I developed and implemented a code blue drill educational experience for OR staff members ...
Surdyk Kathryn K - - 2013
Objective-To determine whether administration of meloxicam or acetylsalicylic acid alters glomerular filtration rate (GFR) in cats with renal azotemia. Animals-6 young adult cats. Procedures-3 sexually intact male cats and 3 sexually intact female cats had surgically reduced renal mass and azotemia comparable to International Renal Interest Society chronic kidney disease ...
Xue Meilan - - 2013
Fucoidan is a sulfated polysaccharide derived from brown algae and is known to possess anticancer properties. However, the relationship between fucoidan and β-catenin, one of the key components of the Wnt signaling pathway, in mouse breast cancer remains poorly characterized. In this study, mouse breast cancer cells (4T1) were exposed ...
Rolando Lori L Health & Wellness, Vanderbilt University, Nashville, TN 37212, - - 2013
To understand risk factor modification effect on Type 2 diabetes incidence in a workforce population. Annual health risk assessment data (N = 3125) in years 1 through 4 were used to predict diabetes development in years 5 through 8. Employees who reduced their body mass index from 30 or more ...
Hermayer Kathie L - - 2013
: There is a huge economic burden of diabetes in South Carolina. : The South Carolina Guidelines for Diabetes Care were based on the 2013 Standards of Medical Care from the American Diabetes Association. : From a review of the Diabetes Quality Indicators in South Carolina 2007, Medicare claims data ...
Risalde María A - - 2013
Objective-To compare pathological changes and viral antigen distribution in tissues of calves with and without preexisting subclinical bovine viral diarrhea virus (BVDV) infection following challenge with bovine herpesvirus-1 (BHV-1). Animals-24 Friesian calves. Procedures-12 calves were inoculated intranasally with noncytopathic BVDV-1a; 12 days later, 10 of these calves were challenged intranasally ...
Martinez Marina - - 2013
After a complete spinal cord injury (SCI) at the lowest thoracic level (T13), adult cats trained to walk on a treadmill can recover hindlimb locomotion within 2-3 weeks, resulting from the activity of a spinal circuitry termed the central pattern generator (CPG). The role of this spinal circuitry in the ...
Qian Yu - - 2013
Peritubular myoid cells (PMCs) are myofibroblast-like cells that surround the seminiferous tubules and play essential roles in male fertility. How these cells modulate spermatogenesis and the signaling pathways that are involved are largely unknown. Here we report that Lgr4 is selectively expressed in mouse PMCs in the testes, and loss ...
van Vliet Martin H MH Skyline Diagnostics BV, Rotterdam, The - - 2013
Mutations in the gene encoding nucleophosmin (NPM1) carry a prognostic value for patients with acute myeloid leukemia (AML). Various techniques are currently being used to detect these mutations in routine molecular diagnostics. Incorporation of accurate NPM1 mutation detection on a gene expression platform would enable simultaneous detection with various other ...
Pelssers Johan - - 2013
This study evaluated "Every Step Counts!"-a 10-wk, structured walking intervention in a community-based senior organization-on promoting physical activity participation, fitness, and well-being among older adults (age ≥ 55 yr). The intervention prescribed pedometer-defined walks in weekly walking schedules. These were fitness-tailored and structured in walking load (intensity/volume) according to the ...
Li Lin - - 2013
To assess dietary isoflavone intake between population and hospital outpatient controls and examine if cancer risks estimated for isoflavone using hospital outpatient controls would be different from those using population controls. Three parallel case-control studies on leukemia, breast, and colorectal cancers in China in 2009-2010 were conducted, using population and ...
Steelman Victoria M - - 2013
Much of the work done by perioperative nurses focuses on patient safety. Perioperative nurses are aware that unreported near misses occur every day, and they use that knowledge to prioritize activities to protect the patient. The purpose of this study was to identify the highest priority patient safety issues reported ...
Mann Brenda - - 2013
: The purpose of this multisite study was to describe suctioning techniques of registered nurses (RNs) and respiratory therapists (RTs) caring for neonates requiring nasal continuous positive airway pressure (CPAP). The care practices investigated included suctioning frequency, assessment parameters, and techniques used to suction. : A convenience sample of neonatal ...
Kaczmarczyk Joseph M - - 2013
Background: This article, prepared by the Association of Professors of Gynecology and Obstetrics Undergraduate Medical Education Committee, discusses the evolving challenges facing medical educators posed by social media and a new form of professionalism that has been termed e-professionalism. Summary: E-professionalism is defined as the attitudes and behaviors that reflect ...
Traustason Sindri - - 2013
To assess the validity of spectrophotometric retinal oximetry by comparison to blood gas analysis and intravitreal measurements of partial pressure of oxygen (pO(2)). Female domestic pigs were used for all experiments (n = 8). Oxygen fraction in inspired air was changed using a mixture of room air, pure oxygen, and ...
Romero Vivian C VC Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, MI, - - 2013
Fetal dysregulation of T helper cell pathways may predispose to allergy, as high cord blood T helper 2/T helper 1 ratios have been shown to precede development of allergic diseases. We aimed to determine whether prenatal eicosapentaenoic acid and docosahexaenoic acid supplementation reduces T helper 2 to T helper 1-associated ...
Santos Vinicius Coneglian - - 2013
Purpose: To investigate the effects of docosahexaenoic-(DHA)-rich fish oil (FO) supplementation on lymphocyte function before and after a marathon race. Methods: Twenty-one athletes participated in this study. Eight marathon runners were supplemented with 3 g of FO daily for 60 d (FO group), and 13 athletes were not supplemented (C ...
Holes-Lewis Kelly Anne - - 2013
Obesity is a world-wide epidemic associated with significant morbidity and mortality which costs billions of dollars per year. The associated related conditions are many and include heart disease, stroke, type II diabetes mellitus, sleep apnea and certain types of cancer. Given that it is a multifactorial problem, the treatments must ...
Martin Blanca - - 2013
To report on 15 cases of Merkel cell carcinoma (MCC) with divergent differentiation, to characterize its clinicopathological spectrum and its relationship with Merkel cell polyomavirus (MCV). Fifteen patients with a mean age of 81 years were included. Follow-up was available for 13 cases (range 12 days to 6 years; median 6 months). Recurrence, metastasis ...
Bretscher Anthony - - 2013
Scientific communication, career advancement, and funding decisions are all dependent on research publications. The way manuscripts are handled by high-visibility, professionally edited magazines differs from the way academic journals evaluate manuscripts, using active scientists as monitoring editors. In this essay, I discuss the benefits that come with the involvement of ...
Leite Renata S RS Division of Periodontics, College of Dental Medicine, Center for Oral Health Research, College of Dental Medicine, Division of Biostatistics and Epidemiology, Charleston, South Carolina 29425, USA. - - 2013
Type 2 diabetes mellitus has been described as a new epidemic. Approximately 285 million people worldwide suffer from diabetes, and this number is predicted to increase by approximately 50% by year 2030. This article will review oral health manifestations of diabetes and discuss associations between periodontal disease and diabetes. Although ...
Feng Weiwei - - 2013
Aims:  The aim of this study was to determine the value of morphometric features in distinguishing mild and moderate atypia and predicting the recurrence of World Health Organization 2003-defined endometrial stromal sarcoma and highly malignant undifferentiated endometrial sarcoma. Methods and results:  Nuclear and cytological size, shape and arrangement were morphometrically ...
Invernizzi Alessandro - - 2013
To assess enhanced depth imaging optical coherence tomography (EDI-OCT) visualization of deep posterior pole structures and retrobulbar tissues in myopic eyes and evaluate ocular structural elements that influence this capability. Thirty consecutive myopic eyes (>-6 diopters) from 21 patients were enrolled. Exclusion criteria included any pathological condition affecting the posterior ...
Paramesh Anil S - - 2013
Advancements in transplantation offer promising treatment options for a variety of diseases. Organ donation, an essential part of organ transplantation, may be performed at hospitals even if the facility is not a transplant center; therefore, perioperative nurses should be aware of developments in transplantation and the implications for patient care ...
Ciccocioppo Rachele - - 2013
We report on 2 patients affected by both celiac disease (CD) and β-thalassemia major who underwent successful myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) for the latter condition. After HSCT, the introduction of a gluten-containing diet did not cause the reappearance of clinical, serological, and histological markers of CD in ...
Sherer Renslow - - 2013
Background : In 2008 Wuhan University Medical School in China proposed to reform its curriculum by adapting the curriculum of the University of Chicago Medical School. Description : An assessment of Wuhan University Medical School's traditional curriculum conducted in 2009 informed the reform directions, which included course integration, use of ...
Mendez-Angulo Jose L - - 2013
Objective-To determine the maximum amount of flexion and extension of the carpal, tarsal, metacarpophalangeal, and metatarsophalangeal joints and the percentage duration of the stance and swing phases of the stride for horses walking on an underwater treadmill in various water depths. Animals-9 healthy adult horses. Procedures-Zinc oxide markers were placed ...
Perreault Marie-Claude - - 2013
Subcortical descending glutamatergic neurons, such as reticulospinal (RS) neurons, play decisive roles in the initiation and control of many motor behaviors in mammals. However, little is known about the mechanisms used by RS neurons to control spinal motor networks because most of the neuronal elements involved have not been identified ...
Zhu Jia-Ying JY Department of Plant Biology, Carnegie Institution for Science, Stanford, CA 94305, - - 2013
The brassinosteroid (BR) class of steroid hormones regulates plant development and physiology. The BR signal is transduced by a receptor kinase-mediated signal transduction pathway, which is distinct from animal steroid signalling systems. Recent studies have fully connected the BR signal transduction chain and have identified thousands of BR target genes, ...
Osman Amira - - 2013
We examined the contribution of socioeconomic disadvantage and traumatic life events to ethnic disparities in disability among Israeli adults. We used data from the Survey of Health, Aging and Retirement in Europe (SHARE-Israel), a sample of Israeli adults aged 50 or older (N = 1,546). Disability measures included functional limitations, ...
Ahern Kathy - - 2013
The purpose of this study was to identify and prioritize topics for a professional development program in neonatal palliative care. A total of 276 nurses and midwives who work in an Australian neonatal intensive care unit (NICU) and 26 international healthcare professionals working in NICU and palliative care served as ...
Mazurkiewicz Rebecca - - 2013
Background: No standards regarding what should be learned during medical school exist. Purpose: We investigated what medical students and clerkship directors (CDs) believe students are, and should be, doing during clerkships. Methods: From January to June 2011, Mount Sinai School of Medicine CDs (n = 4) and 3rd-year students (n ...
Wu Zhichao - - 2013
The second hyper-reflective on spectral domain optical coherence tomography (SD-OCT) has been suggested to correlate with the photoreceptor inner segment ellipsoids (ISe). The purpose of our study was to determine the relationship between the intensity of the ISe band and retinal function measured by multifocal electroretinography (mfERG) in patients with ...
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