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Kapoor Arun A Laboratory of Molecular Neurobiology, Institute of Cellular and Organismic Biology , Academia Sinica, Taipei, - - 2013
Retinoic acid (RA)-elicited signaling has been shown to play critical roles in development, organogenesis, and the immune response. RA regulates expression of Alzheimer's disease (AD)-related genes and attenuates amyloid pathology in a transgenic mouse model. In this study, we investigated whether RA can suppress the production of amyloid-β (Aβ) through ...
Colaneri Michael J MJ Department of Chemistry and Physics, State University of New York at Old Westbury, Old Westbury, New York 11568, USA. - - 2013
Electron paramagnetic resonance (EPR) spectroscopy was used to study Cu(II) dynamic behavior in a doped biological model crystal, bis(L-histidinato)cadmium dihydrate, in order to gain better insight into copper site stability in metalloproteins. Temperature-dependent changes in the low temperature X-band EPR spectra became visible around 100 K and continued up to ...
Kline Chelsey D CD Institute of Environmental, Health, Oregon Health and Sciences University, Beaverton, Oregon 97006, - - 2013
Peptidylglycine monooxygenase is a copper-containing enzyme that catalyzes the amidation of neuropeptides hormones, the first step of which is the conversion of a glycine-extended pro-peptide to its α-hydroxyglcine intermediate. The enzyme contains two mononuclear Cu centers termed CuM (ligated to imidazole nitrogens of H242, H244 and the thioether S of ...
Lu Ping P The Wallace H. Coulter Department of Biomedical Engineering, School of Chemistry and, Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United - - 2013
This article presents a simple and reliable method for generating polystyrene (PS) yarns composed of bundles of nanofibrils by using a proper combination of solvent and relative humidity. We elucidated the mechanism responsible for the formation of this new morphology by systematically investigating the molecular interactions among the polymer, solvent(s), ...
Gunderson Erin G - - 2013
Objective-To compare effects of anesthetic induction with midazolam-propofol or midazolam-etomidate on intraocular pressure (IOP), pupillary diameter (PD), pulse rate, blood pressure, and respiratory rate in clinically normal dogs. Animals-18 dogs. Procedures-Dogs undergoing ophthalmic surgery received midazolam (0.2 mg/kg, IV) and either propofol or etomidate (IV) until intubatable. For all dogs, ...
Hayes Madeline - - 2013
Using zebrafish, we have characterised the function of Protein tyrosine kinase 7 (Ptk7), a transmembrane pseudokinase implicated in Wnt signal transduction during embryonic development and in cancer. Ptk7 is a known regulator of mammalian neural tube closure and Xenopus convergent extension movement. However, conflicting reports have indicated both positive and ...
Vidal-Casariego Alfonso - - 2013
Glutamine is a nutraceutic with antioxidant and immune functions that can protect from adverse effects associated with radiation therapy (RT). The aim of this study was to test whether oral glutamine prevents oral mucositis (OM) or acute radiation-induced esophagitis (ARIE) and favors nutritional status. This retrospective, cohort study included patients ...
Lewis Katherine - - 2013
: Transition of care from a child-centered care environment to an adult-centered care environment for pediatric patients with diabetes is needed to ensure continued diabetes care. The transition process should start early and be tailored to the developmental stage of the patient. The typical challenges of adolescence and young adulthood ...
Stahelin Robert V - - 2013
Surface plasmon resonance (SPR) is a powerful technique for monitoring the affinity and selectivity of biomolecular interactions. SPR allows for analysis of association and dissociation rate constants and modeling of biomolecular interaction kinetics, as well as for equilibrium binding analysis and ligand specificity studies. SPR has received much use and ...
Woods Katharine S - - 2013
Objective-To compare the diagnostic quality of bronchoalveolar lavage (BAL) fluid acquired from healthy dogs by manual aspiration via polyethylene tubing (MAPT) and via suction pump aspiration (SPA) with a suction trap connection. Animals-12 healthy adult Beagles. Procedures-BAL was performed with bronchoscopic guidance in anesthetized dogs. The MAPT was performed with ...
Vallstedt Anna - - 2013
During neuronal circuit formation, axons are guided to their targets by the help of axon guidance molecules, which are required for establishing functional circuits. A promising system to dissect the development and functionalities of neuronal circuitry is the spinal cord central pattern generator (CPG) for locomotion, which converts a tonic ...
Bracht Marianne - - 2013
The purpose of this study was to develop, implement, and evaluate a parent education and support program that enhances family-integrated care in a Canadian neonatal intensive care unit (NICU). A total of 39 mothers of infants born at 35 or fewer weeks' gestation were enrolled in the pilot program. We ...
Green Jonas - - 2013
Background: Stewardship is an important aspect of medical care to which little formal attention is paid during training. Purpose: The goal is to evaluate stewardship practices of internal medicine residents and the relationship of resident refusal to provide requested nonindicated care with levels of confidence and bother. Methods: Cross-sectional survey ...
Surdyk Kathryn K - - 2013
Objective-To determine whether administration of meloxicam or acetylsalicylic acid alters glomerular filtration rate (GFR) in cats with renal azotemia. Animals-6 young adult cats. Procedures-3 sexually intact male cats and 3 sexually intact female cats had surgically reduced renal mass and azotemia comparable to International Renal Interest Society chronic kidney disease ...
Xue Meilan - - 2013
Fucoidan is a sulfated polysaccharide derived from brown algae and is known to possess anticancer properties. However, the relationship between fucoidan and β-catenin, one of the key components of the Wnt signaling pathway, in mouse breast cancer remains poorly characterized. In this study, mouse breast cancer cells (4T1) were exposed ...
Probst Curtis W - - 2013
Objective-To evaluate the pharmacokinetics of diazepam administered per rectum via compounded (ie, not commercially available) suppositories and determine whether a dose of 2 mg/kg in this formulation would result in plasma concentrations shown to be effective for control of status epilepticus or cluster seizures (ie, 150 to 300 ng/mL) in ...
Wenner Peter - - 2013
Endocannabinoid signaling typically mediates a form of synaptic plasticity in which a postsynaptic cell acts retrogradely to reduce vesicle release from presynaptic terminals impinging on that cell. In the embryonic spinal cord, endocannabinoids inhibit spontaneously released glutamatergic vesicles in both a brief and ongoing tonic manner. Together these endocannabinoid-mediated forms ...
Wolf Andrea - - 2013
The hypothalamus is a key integrative center in the brain that consists of diverse cell types required for a variety of functions including homeostasis, reproduction, stress response, social and cognitive behavior. Despite our knowledge of several transcription factors crucial for hypothalamic development, it is not known how the wide diversity ...
Lowcock Elizabeth C - - 2013
Associations between caffeine and coffee consumption and breast cancer risk are uncertain, with studies suggesting inverse and null associations. Variation in cytochrome P450 1A2 (CYP1A2), a gene responsible for caffeine metabolism, may modify these associations. Cases (n = 3,062) were recruited through the Ontario Cancer Registry and controls (n = ...
Kwon Soonho - - 2013
: Provide treatment guidelines for glucocorticoid-induced hyperglycemia and to understand the clinical implications of glucocorticoid-induced hyperglycemia. : The authors analyzed an electronic search (Medline) and a literature review of the pertinent articles published from 1980 to September 2012. : In patients treated with glucocorticoids, the odds ratio for development of ...
Blatter - - 2013
In April 2008 a Franches-Montagnes colt was born with an unusual coat colour phenotype which had never been observed in that population before. The foal showed extended white markings on body and legs, a white head and blue eyes. As both parents have an unremarkable bay coat colour phenotype, a ...
Stein Paul S G - - 2013
Studies of the model systems of spinal cord and brainstem reveal molecular, genetic, and cellular mechanisms that are critical for network and behavioral functions in the nervous system. Recent experiments establish the importance of neurogenetics in revealing cellular and network properties. Breakthroughs that utilize direct visualization of neuronal activity and ...
Benson Stacey M - - 2013
Proper adherence to infection control precautions, including appropriate selection and use of personal protective equipment (PPE), is of significant importance to the health and well-being of perioperative personnel. Surgical masks are intended for use as a barrier to protect the wearer's face from large droplets and splashes of blood and other ...
Pospischil - - 2013
Aim of this study is to present a survey of the dog population and breed distribution in Switzerland from 1955 to 2008 as basis to realize a population based canine cancer register for Switzerland. The number of dogs rose from 309'000 in 1955 to approximately 500'000 in 2008 correlating with ...
Kotey Francesca O - - 2013
Human milk has been found to be beneficial for the development of all newborns. It is protective during the development of the gastrointestinal tract, important in neurologic development, immune system function, and nourishment. Human milk has a number of components that aid in the anti-inflammatory process and free radical reduction ...
Lin Yi-Ting - - 2013
This research focused on a Chinese herb medicine, Solanum lyratum Thunb (Solanaceae) by ethanol extracts (SLE) for investigating the molecular anticancer mechanism in vitro for exploring the means of cell death through the effects on mitochondrial function. We found that SLE induced cytotoxic effects in human osteosacroma U-2 OS cells, ...
Lanfranchi Joy A - - 2013
A code blue in the OR is a low-volume, high-risk event. To be effective during a code blue event, perioperative personnel must be able to properly execute a response plan and perform seldom-used skills and procedures. I developed and implemented a code blue drill educational experience for OR staff members ...
Sarkars Ruma - - 2013
Heat shock proteins (HSPs) are chaperones for several client proteins involved in transcriptional regulation, signal transduction, and cell cycle control. HSPs (27, 70, and 90) are abundantly expressed in a wide range of cancers and are transcriptionally regulated by heat shock factor (HSF1). Most of the synthetic HSP inhibitors exhibit ...
Kim Sarang - - 2013
Background: Graduating medical students have reported concern regarding inadequate training in pharmacotherapy. Teaching by clinical pharmacists may improve medical students' pharmacotherapy knowledge. Purpose: To assess the impact of pharmacist led workshops on 4th year medical students' knowledge of pharmacotherapy and satisfaction. Methods: Senior medical students enrolled in intensive care unit ...
Cooley Stacy D - - 2013
Objective-To characterize and quantitatively assess the typical pulmonary anatomy of healthy adult alpacas with multidetector row CT. Animals-10 clinically normal adult female alpacas. Procedures-CT examination of the thorax was performed before and after IV administration of iodinated contrast medium in sedated alpacas in sternal recumbency. Measurements of the trachea, bronchi ...
Liu Chunyi - - 2013
This article reports, for the first time, on the absolute configuration of (+)-9-benzyloxy-α-dihydrotetrabenazine (8), as determined from the perspective of X-ray crystallography. Compound 8 was prepared by a six-step reaction using 3-benzyloxy-4-methoxybenzaldehyde (1) as a starting material. The X-ray crystal diffraction structure of two compounds, racemic 9-benzyloxy-tetrabenazine (5) and the ...
Jackson Maria - - 2013
Studies of diet and prostate cancer have focused primarily on food and nutrients; however, dietary patterns examine the overall diet, particularly foods eaten in combination, and risk of disease. We evaluated the association of dietary patterns and prostate cancer and low- and high-grade subgroups in Jamaican men. In a case-control ...
Snapp Barbara - - 2013
Bordetella pertussis is a highly contagious bacterial disease currently on the rise in the United States. The most vulnerable age group is infants younger than 1 year old. The reasons for the current outbreak are multifactorial. The following is a case report describing a recent case of Bordetella pertussis infection ...
Chiu Tsan-Hung - - 2013
Diallyl sulfide (DAS) is a component of garlic (Alliaceae family). Although diallyl polysulfide has been shown to exhibit anticancer activities, no report explored DAS-affected cell death in human cervical cancer cells in vitro. This study investigated DAS affected on cell-cycle regulation and apoptosis in human cervical cancer Ca Ski cells. ...
Ariail Jennie - - 2013
Background: Students often enter graduate healthcare/biomedical schools with insufficient undergraduate instruction in effective writing, yet the ability to write well affects their career opportunities in health care and in scientific research. Purpose: The present study was conducted to determine the value and effectiveness of instruction by faculty with expertise in ...
Risalde María A - - 2013
Objective-To compare pathological changes and viral antigen distribution in tissues of calves with and without preexisting subclinical bovine viral diarrhea virus (BVDV) infection following challenge with bovine herpesvirus-1 (BHV-1). Animals-24 Friesian calves. Procedures-12 calves were inoculated intranasally with noncytopathic BVDV-1a; 12 days later, 10 of these calves were challenged intranasally ...
Martinez Marina - - 2013
After a complete spinal cord injury (SCI) at the lowest thoracic level (T13), adult cats trained to walk on a treadmill can recover hindlimb locomotion within 2-3 weeks, resulting from the activity of a spinal circuitry termed the central pattern generator (CPG). The role of this spinal circuitry in the ...
Qian Yu - - 2013
Peritubular myoid cells (PMCs) are myofibroblast-like cells that surround the seminiferous tubules and play essential roles in male fertility. How these cells modulate spermatogenesis and the signaling pathways that are involved are largely unknown. Here we report that Lgr4 is selectively expressed in mouse PMCs in the testes, and loss ...
Li Lin - - 2013
To assess dietary isoflavone intake between population and hospital outpatient controls and examine if cancer risks estimated for isoflavone using hospital outpatient controls would be different from those using population controls. Three parallel case-control studies on leukemia, breast, and colorectal cancers in China in 2009-2010 were conducted, using population and ...
Vidaeff Alex C - - 2013
To determine the relation between thrombin generation (measured by thrombin-antithrombin [TAT] complexes) early in pregnancy and subsequent preterm delivery. Select cohort of 731 women undergoing indicated second trimester amniocentesis prospectively followed to delivery. Primary outcome was preterm delivery. TAT levels were examined continuously and categorized by quartiles. Multivariable techniques were ...
Dong Jingmei - - 2013
Purpose: To examine the excessive reactive oxygen species (ROS) mediated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and the combined effect of glutamine supplementation and diphenyleneiodonium (DPI) on the function of neutrophils induced by overtraining. Methods: Fifty male Wistar rats were randomly divided into 5 groups: control group (C), overtraining ...
Cates Leigh Ann - - 2013
Neonatal nurse practitioners (NNPs) have a crucial role in the management and care of critically ill newborns and infants in the neonatal intensive care unit. Their role responsibilities range from daily management of care, oversight of unit and bedside education, execution of advanced procedures, and attendance at high-risk deliveries. During ...
Del Follo-Martinez Armando - - 2013
Resveratrol and quercetin (RQ) in combination (1:1 ratio) previously inhibited growth in human leukemia cells. This study investigated the anticancer activity of the same mixture in HT-29 colon cancer cells. RQ decreased the generation of reactive oxygen species (ROS) by up to 2.25-fold and increased the antioxidant capacity by up ...
Clauson Kevin A - - 2013
Background: Social media may offer a means to engage students, facilitate collaborative learning, and tailor educational delivery for diverse learning styles. Purpose: The purpose of this study is to characterize social media awareness among pharmacy students and determine perceptions toward integrating these tools in education. Methods: A 23-item survey was ...
Drab Scott - - 2013
: The roles of the diabetes educator (DE) have expanded significantly from the basic instruction on self-care on which the profession was established and now encompass a range of key responsibilities within diabetes care. A major focus of recent literature has been evaluation of the effectiveness of diabetes self-management education ...
Alghamdi Ali Saad Thafeed - - 2013
: This pilot study investigated the efficacy of dental clinics as potent sources for screening diabetes and prediabetes in undiagnosed individuals. : Data were randomly collected from 385 patients (aged 40 years and older) visiting dental clinics. Patients already having a diagnosis of diabetes and/or prediabetes were excluded. Demographic data, ...
Champ Colin E - - 2013
Recent data reveals that dietary factors may influence outcomes in patients undergoing cancer treatment. However, patient-centered information on dietary recommendations is limited. In this study, we assessed dietary recommendations for cancer patients during treatment and survivorship by evaluating the websites of all National Comprehensive Cancer Network (NCCN) member institutions. NCCN ...
Mullen Linda - - 2013
Simulation learning provides medical and nursing personnel with the opportunity to develop and refine their skills without putting patients at risk. Faced with ensuring the competence of a large number of new staff members, the management team at one facility implemented a simulation training program. Surgical team members are able ...
Hermayer Kathie L - - 2013
: There is a huge economic burden of diabetes in South Carolina. : The South Carolina Guidelines for Diabetes Care were based on the 2013 Standards of Medical Care from the American Diabetes Association. : From a review of the Diabetes Quality Indicators in South Carolina 2007, Medicare claims data ...
Sherer Renslow - - 2013
Background : In 2008 Wuhan University Medical School in China proposed to reform its curriculum by adapting the curriculum of the University of Chicago Medical School. Description : An assessment of Wuhan University Medical School's traditional curriculum conducted in 2009 informed the reform directions, which included course integration, use of ...
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