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Doupé David P DP The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, - - 2013
It has recently been shown that stem and progenitor cells undergo population self-renewal to maintain epithelial homeostasis. The fate of individual cells is stochastic but the production of proliferating and differentiating cells is balanced across the population. This new paradigm, originating in mouse epidermis and since extended to mouse oesophagus ...
Kocbek Vida - - 2013
Abstract The aim of this study was to evaluate serum and peritoneal fluid (PF) glycodelin-A concentrations in women with ovarian endometriosis. Ninety-nine matched pairs of serum and PF samples were included in our study. The case group comprised 57 women with ovarian endometriosis and the control group 42 healthy women ...
Patel J C - - 2013
1 As selective serotonin reuptake inhibitors have an inhibitory effect on nicotinic acetylcholine receptors, they may affect the neuromuscular transmission and interact with neuromuscular blockers. This study was designed to observe the effect of fluoxetine on neuromuscular transmission and its interaction with rocuronium using the rat phrenic nerve hemidiaphragm and ...
Haddad Fernanda Louise Martinho - - 2013
BACKGROUND: The few studies that examine the effect of nasal abnormalities on continuous positive airway pressure device (CPAP) adherence are controversial. The aim of this study was to evaluate the contribution of nasal abnormalities in CPAP adherence. METHODS: We included patients with moderate to severe OSA. The patients were submitted ...
Wang Lei - - 2013
Fe2N nanoparticles and nitrogen-doped graphitic nanosheet composites (Fe2N-NGC) have been synthesized by an ion-exchanged route, which can serve as an efficient non-precious metal electrocatalyst with a 4e- reaction pathway for oxygen reduction reactions (ORR).
Park Mi-Ri - - 2013
Using yeast two-hybrid assays and a Nicotiana benthamiana cDNA library, we previously identified an N. benthamiana protein, NbPCIP1, that interacts with Potato virus X (PVX) coat protein (CP). We also previously determined that NbPCIP1 enhances PVX replication in plants. To determine the domains and/or amino acid residues required for PVX ...
Blake Glen M - - 2013
PURPOSE: Measurements of glomerular filtration rate (GFR) are frequently interpreted assuming a linear variation with age. Nonlinear relationships may give a better representation of the changes associated with normal ageing. METHODS: This was a retrospective study of 904 subjects (468 women, 436 men; age range 18-84 years) undergoing assessment as prospective ...
Ali R H - - 2013
Pure hair and nail ectodermal dysplasia (PHNED; MIM 602032) is a congenital disorder characterized by presence of sparse to absent hairs on scalp and/or rest of the body, and appearance of dystrophic nails. The condition is inherited both in autosomal dominant 1 and recessive 2 manners. The autosomal recessive form ...
Sánchez Marta I - - 2013
Brine shrimp, Artemia spp., act as intermediate hosts for a range of cestode species that use waterbirds as their final hosts. These parasites can have marked influences on shrimp behavior and fecundity, generating the potential for cascading effects in hypersaline food webs. We present the first comprehensive study of the ...
Ishii Wataru - - 2013
Abstract Amyloid A (AA) amyloidosis is a fatal disease caused by extracellular deposition of fibrils derived from serum AA (SAA). AA amyloid fibril formation has previously been modeled in macrophage cultures using highly amyloidogenic mouse SAA1.1, but attempts to do the same with human SAA invariably failed. Our objective was ...
Paulucci N S - - 2013
AIMS: The aim of this work was to clarify the mechanism of monounsaturated fatty acid (MUFA) synthesis in Bradyrhizobium TAL1000 and the effect of high temperature on this process. METHODS AND RESULTS: Bradyrhizobium TAL1000 was exposed to a high growth temperature and heat shock, and fatty acid composition and synthesis ...
Hattiwale Shaheenkousar H - - 2013
Nickel sulfate stimulates inducible nitric oxide synthase (i-NOS) and increases serum nitric oxide concentration by overproduction of reactive nitrogen species due to nitrosative stress. The present study was undertaken to assess possible protective role of L-ascorbic acid as an antioxidant against nickel induced pulmonary nitrosative stress in male albino rats. ...
Morrison P J PJ Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York, York, - - 2013
Bacterial-induced intestinal inflammation is crucially dependent on interleukin (IL)-23 and is associated with CD4(+) T helper type 1 (Th1) and Th17 responses. However, the relative contributions of these subsets during the induction and resolution of colitis in T-cell-sufficient hosts remain unknown. We report that Helicobacter hepaticus-induced typhlocolitis in specific pathogen-free ...
Carpi Angelo - - 2013
Subclinical hyperthyroidism (SH) has been reported associated with atrial fibrillation (AF), heart failure (HF) and coronary heart disease events, including mortality. An expert opinion indicates that AF is the possible link between SH and the other important cardiovascular (CV) manifestations. We analyzed the data of three recent studies including 60,883 ...
Deroy Ophelia - - 2013
Olfactory experiences represent a domain that is particularly rich in crossmodal associations. Whereas associations between odors and tastes, or other properties of their typical sources such as color or temperature, can be straightforwardly explained by associative learning, other matchings are much harder to explain in these terms, yet surprisingly are ...
Ma Rujun - - 2013
We report transparent stretchable single-walled carbon nanotube-polymer composite films that emit pronounced Raman and near-infrared fluorescence with a fine spatial resolution. The independent modulation in Raman and fluorescence spectra is demonstrated in response to touch and temperature. The optical signal transduction of transparent stretchable optoelectronic films may enable a paradigm ...
Lee Mee-Young - - 2013
Abstract Objective: Pinellia ternata is an important plant in traditional Chinese medicine. This study describes the anti-inflammatory effects of a water extract of P. ternata (PTE) in allergic airway inflammation in a model of asthma in mice. Materials and methods: BALB/c mice were sensitized with ovalbumin (OVA) and, upon an ...
Nishiyama Akira - - 2013
Networks of transcription factors (TFs) are thought to determine and maintain the identity of cells. Here we systematically repressed each of 100 TFs with shRNA and carried out global gene expression profiling in mouse embryonic stem (ES) cells. Unexpectedly, only the repression of a handful of TFs significantly affected transcriptomes, ...
Moretti Franco A - - 2013
This 8-year longitudinal study was aimed to analyze the HIV-1 gp120-C2V3C3 sequence dynamics, their phylogenetic relationships and tropism evolution in patients under HAART. Such viral analysis comprised two compartments: plasma and PBMC. Fifty gp120-C2V3C3 genomic sequences were characterized from 16 patients: 41 from plasma when viremia was measurable and 9 ...
Sun Xiaodong - - 2013
PURPOSE: To determine whether para- and perirenal fat ultrasonographic thickness (PFUT) is related to increased urinary albumin excretion and whether PFUT is an independent indicator of early kidney damage in obese subjects. METHOD: Sixty-seven nonhypertensive, nondiabetic obese patients and 34 age- and sex-matched normal healthy volunteers were involved in this ...
Srivastava Saurabh - - 2013
Reduced graphene oxide (RGO) due to its excellent electrochemical properties and large surface area, has recently aroused much interest for electrochemical biosensing application. Here, the chemically active RGO has been synthesized and deposited onto an indium tin oxide (ITO) coated glass substrate by the electrophoretic deposition technique. This novel platform ...
Chiu Ching-Ju CJ Institute of Gerontology, College of Medicine, National Cheng Kung University, No. 1, University Road, Tainan, Taiwan 70101. - - 2013
Few longitudinal studies have examined associations between body mass index (BMI) changes in adults with diabetes and the development of disability. To investigate association patterns between BMI and disability in middle-aged adults with diabetes. Retrospective cohort design with data from the 1992-2006 Health and Retirement Study (HRS). A group-based joint ...
Sacco J E - - 2013
Background:Historically, the voluntary addition of micronutrients to foods in the United States has been regarded as an important means to lessen problems of nutrient inadequacy. With expanding voluntary food fortification and widespread supplement use, it is important to understand how voluntary food fortification has an impact on the likelihood of ...
Khanna Ankita - - 2013
Wastewater released from textile industries causes water pollution, and it needs to be treated before discharge to the environment by cost effective technologies. Solar photocatalysis is a promising technology for the treatment of dye wastewater. The Ag@TiO2 nanoparticles comprising of Ag core and TiO2 shell (Ag@TiO2) have unique photocatalytic property ...
Krijgsheld Pauline - - 2013
Aspergillus niger is a cell factory for the production of enzymes. This fungus secretes proteins in the central part and at the periphery of the colony. The sporulating zone of the colony overlapped with the non-secreting sub-peripheral zone, indicating that sporulation inhibits protein secretion. Indeed, strain ∆flbA that is affected ...
Richardson Arthur J - - 2013
BACKGROUND: By attenuating the systemic inflammatory response to major surgery, the pre-operative administration of steroids may reduce the incidence of complications. METHODS: A systematic review was conducted to identify randomized controlled trials (RCT) comparing pre-operative steroid administration with placebo during a liver resection. Meta-analyses were performed. RESULTS: Five RCTs were ...
Gustafson Alison - - 2013
OBJECTIVE: The aim of the study was to determine the association between dietary outcomes and the neighbourhood food environment (street network distance from home to stores) and consumer food environment (Nutrition Environment Measurement Survey-Stores (NEMS-S) audit). DESIGN: The neighbourhood food environment was captured by creating 0·5-mile and 1-mile network distance ...
Nakashita Rumiko - - 2013
We determined the magnitude of isotopic fractionation of carbon and nitrogen stable isotope ratios (as enrichment factors, Δδ13C and Δδ15N, respectively) between the tissues and diets of captive Japanese macaques (Macaca fuscata) using a controlled feeding experiment, to provide basic data for reconstructing their feeding habits. The Δδ13C and Δδ15N ...
Phillips L K - - 2013
Background/Objectives:Recent work suggests that macronutrients are pro-inflammatory and promote oxidative stress. Reports of postprandial regulation of total adiponectin have been mixed, and there is limited information regarding postprandial changes in high molecular weight (HMW) adiponectin. The aim of this study was to assess the effect of a standardised high-fat meal ...
Benzeval Ian - - 2013
PURPOSE: To investigate whether permeation enhancement techniques affect the nail plate. METHODS: Infrared and impedance spectroscopies examined the effects of hydration, iontophoresis and N-acetyl-L-cysteine on the human nail. RESULTS: While significant shifts to higher wavenumbers were observed for the symmetric and asymmetric -CH2 stretching vibrations these changes were essentially the ...
Lledó Agustí - - 2013
Medium sized trans-cycloalkenes are unusually reactive in the intermolecular Pauson-Khand reaction (PKR) with regard to typical monocyclic alkenes. This is due to the ring strain imparted by the E stereochemistry. The PKR of these alkenes offers a modular, regioselective and straightforward entry to trans fused [n.3.0] bicyclic scaffolds (n = ...
Kim Yeon-Joo YJ Research Institute and Hospital, National Cancer Center, Goyang, South - - 2013
We analyzed the treatment outcomes of intracranial ependymomas in Korean children aged <18 years. Data for 96 patients were collected from five hospitals. Survival rates were calculated using the Kaplan-Meier method. Log-rank tests for univariate analyses and Cox regression model for multivariate analysis were conducted to identify prognostic factors for ...
Weston Mitchell H - - 2013
Porous organic polymers bearing metal-catecholate groups were evaluated for their ability to remove airborne ammonia, cyanogen chloride, sulphur dioxide, and octane by micro-breakthrough analysis. For ammonia, the metal-catecholate materials showed remarkable uptake under humid conditions.
Kim S Y - - 2013
The human supraspinatus muscle is clinically important as it is frequently injured in older adults and the elderly. We have previously shown that the supraspinatus has a complex architecture with two distinct regions each consisting of three parts. Further we have found dynamic changes in architectural parameters such as fiber ...
Ide Jaime S - - 2013
Alcohol use and misuse is known to involve structural brain changes. Numerous imaging studies have examined changes in gray matter (GM) volumes in dependent drinkers, but there is little information on whether non-dependent drinking is associated with structural changes and whether these changes are related to psychological factors-such as alcohol ...
Sun Wei-Lun - - 2013
Abstinence from cocaine self-administration (SA) is associated with neuroadaptations in the prefrontal cortex (PFC) and nucleus accumbens (NAc) that are implicated in cocaine-induced neuronal plasticity and relapse to drug-seeking. Alterations in cAMP-dependent protein kinase A (PKA) signaling are prominent in medium spiny neurons in the NAc after repeated cocaine exposure ...
Nowak Przemysław - - 2013
The present study explored the antinociceptive effects of H3 (R-alpha-methylhistamine) and GABAB (baclofen) receptor ligands in an orofacial model of pain in rats. Orofacial pain was induced by subcutaneous injection of formalin (50 μl, 5 %) in the upper lip region, and the number of jumps and time spent face rubbing was ...
Sim Jaesam - - 2013
We propose a gas sensor operable over a wide temperature range and using suspended GaN nanowires functionalized with Pt-Pd. The sensor is batch-fabricated by directly integrating the GaN nanowires onto batch-processed silicon microelectrodes in parallel. The high thermal stability of the sensor originates from a large band gap of GaN ...
Reid David W - - 2013
Cystic fibrosis (CF) is the most common lethal genetic disorder in Caucasians, affecting more than 3,600 people in Australia and New Zealand, and more than 70,000 globally. Most of the morbidity and mortality relates to chronic airway infection commencing in early infancy and death usually occurs from respiratory failure (1, ...
Goldsmith S M - - 2013
The focus of Luttrell et al.'s recent publication that reports a clinical sensitivity of melanoma identification of 91.2%, and a sensitivity of diagnosis with added dermoscopy of 94.0%, is the enhanced sensitivity of melanoma identification with laypersons' use of dermoscopy.1 The new diagnostic approach that may have resulted in the ...
Barry Mitchel - - 2013
Whole breast irradiation (WBI) over 5-7 weeks has long been considered standard adjuvant treatment after breast-conserving surgery. Recently the concept of irradiating the whole breast has been challenged by accelerated partial breast irradiation (APBI), which exclusively targets the lumpectomy site plus margin. We review the evidence supporting APBI from modern clinical ...
Park Hosik - - 2013
Electrospinning and galvanic displacement reaction were combined to synthesize ultra-long hollow tellurium (Te) nanofibers with controlled dimensions, morphology and crystallinity by simply tailoring the electrolyte concentration applied. Within different morphologies of nanofibers, the branched Te nanostructure shows the greatest sensing performance towards NO2 at room temperature.
Healey Christine - - 2013
There is a paucity of research on self-harm during pregnancy and the postpartum period despite suicide being a leading cause of death and high rates of mental disorder during this time. This audit describes a cohort of women referred to a new perinatal mental health team (PMHT) based in a ...
Guy Shlomit - - 2013
Integration of the HIV cDNA into the host chromosome is a key event in the viral replication cycle. It is mediated by the viral integrase (IN) enzyme, which is an attractive anti-HIV drug target. Here we present the first AFM imaging of IN-mediated DNA integration products in a two-LTR system.
McGill Mitchell R MR Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, Kansas 66160, - - 2013
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver. The first studies of APAP metabolism and activation were published more than 40 years ago. Most of the drug is eliminated by glucuronidation and sulfation. ...
Harms H - - 2013
OBJECTIVES: Stroke-associated pneumonia (SAP) is a common complication with a known negative impact on neurological outcome. We developed a score to identify patients at highest risk of SAP in order to promote prophylactic measures. MATERIALS AND METHODS: We conducted a cohort study on a neurological intensive care unit in patients ...
Nordén Marcus - - 2013
In the eggs and developing chick livers in the two wild bird species, great cormorant and herring gull, the concentrations of a range of 15 perfluoroalkyl acids (PFAAs) were determined. Eggs of the two species were collected from Lake Vänern, Sweden, and analysed either as undeveloped egg (whole egg or ...
Wang Dahong - - 2013
To investigate the effect of fungal elicitors on biosynthesis of natamycin in the cultures of Streptomyces natalensis HW-2, the biomass and filtrate of the broth from Aspergillus niger AS 3.6472, Penicillium chrysogenum AS 3.5163, A. oryzae AS 3.2068, and Saccharomyces cerevisiae AS 2.2081 were used to induce natamycin production in ...
Tsunoda Shigeru - - 2013
PURPOSE: The safety and feasibility of laparoscopic gastrectomy (LG) for patients who have undergone previous upper abdominal surgery (PUAS) remain unclear. A matched-pair analysis was conducted to compare the short-term outcomes of LG between patients with gastric cancer who had undergone PUAS and those who had not. METHODS: A matched-pair ...
Chang Ze - - 2013
Microporous organic polymers (MOPs), an emerging class of functional porous materials featured with the pure organic component have been widely studied in recent years. These materials have potential uses in areas such as storage, separation, and catalysis. In this Perspective, we focused on the gas storage and separation of MOPs. ...
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