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Harriott Andrea M - - 2013
In a recent meta-analysis migraine was associated with a two-fold increase in stroke risk. While the mechanism driving this association is unknown, one intriguing hypothesis is that migraineurs are genetically predisposed to developing ischemic stroke. Mutations in the ATP1A2 gene are implicated in familial hemiplegic migraine type II and increase ...
Langevin Helene M HM Department of Neurological Sciences, University of Vermont, Burlington, Vermont 05405, USA. - - 2013
Fibroblasts in whole areolar connective tissue respond to static stretching of the tissue by expanding and remodeling their cytoskeleton within minutes both ex vivo and in vivo. This study tested the hypothesis that the mechanism of fibroblast expansion in response to tissue stretch involves extracellular ATP signaling. In response to ...
Gilabert Marine M Cancer Research Center of Marseille, INSERM U624, Marseille, - - 2013
We hypothesized that inhibiting molecules that mediate the adaptation response to cellular stress can antagonize the resistance of pancreatic cancer cells to chemotherapeutic drugs. Toward this end, here, we investigated how VMP1, a stress-induced autophagy-associated protein, modulate stress responses triggered by chemotherapeutic agents in PDAC. We find that VMP1 is ...
Kim Jae-Sung JS Section of Rheumatology, Department of Biochemistry, Rush University Medical Center, Chicago, Illinois 60612, - - 2013
The catabolic cytokine interleukin-1 (IL-1) and endotoxin lipopolysaccharide (LPS) are well-known inflammatory mediators involved in degenerative disc disease, and inhibitors of IL-1 and LPS may potentially be used to slow or prevent disc degeneration in vivo. Here, we elucidate the striking anti-catabolic and anti-inflammatory effects of bovine lactoferricin (LfcinB) in ...
Liem Inge S IS Department for Trauma Surgery and Sports Medicine, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, - - 2013
Patients who sustain osteoporotic fractures have excessive mortality compared to age-matched controls, which is most pronounced within the first 6 months postfracture. However, the timing and cause of death in the first 3 months after sustaining a fracture are unclear. We therefore evaluated and compared the timing and cause of ...
Cruz-Correa Marcia M University of Puerto Rico Comprehensive Cancer Center, PO Box 365067, San Juan, PR, 00936, USA, - - 2013
Several genetically defined hereditary colorectal cancer (CRC) syndromes are associated with colonic polyposis including familial adenomatous polyposis (FAP) and MUTYH adenomatous polyposis (MAP). Limited data exists on the clinical characterization and genotypic spectrum of polyposis syndromes among Hispanics. To describe the phenotype and genotype of Puerto Rican Hispanic patients with ...
Fergus Daniel J DJ Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, - - 2013
Estrogens play a salient role in the development and maintenance of both male and female nervous systems and behaviors. The plainfin midshipman (Porichthys notatus), a teleost fish, has two male reproductive morphs that follow alternative mating tactics and diverge in multiple somatic, hormonal, and neural traits, including the central control ...
Alayev Anya A Department of Biology, Stern College for Women of Yeshiva University, New York, New York 10016, - - 2013
Mammalian target of rapamycin (mTOR) is a major intersection that connects signals from the extracellular milieu to corresponding changes in intracellular processes. When abnormally regulated, the mTOR signaling pathway is implicated in a wide spectrum of cancers, neurological diseases, and proliferative disorders. Therefore, pharmacological agents that restore the regulatory balance ...
Jakovljevic Djordje G DG Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK. - - 2013
Autonomic dysfunction has been reported in patients with NAFLD (non-alcoholic fatty liver disease) and is associated with clinical presentations. To date, there are no therapies to improve autonomic regulation in people with NAFLD. The present study defines the impact of a short-term exercise programme on cardiac autonomic and haemodynamic regulation ...
Toche-Manley Linda L LL Polaris Health Directions, 444 Oxford Valley Road, Suite 300, Langhorne, PA 19047, USA. - - 2013
Outcomes management technology holds great promise for improving the quality of services provided to youth in the child welfare system. Advantages include better detection of behavioral health and trauma-related issues, early indicators of case progress or risk of failure, and program- and system-level learning. Yet organizational barriers to implementation persist. ...
Mutanen Annika A Section of Pediatric Surgery, Children's Hospital, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland. - - 2013
The aim of this study was to evaluate the long-term effects of pediatric intestinal failure (IF) on liver histology. Altogether, 38 IF patients (median age: 7.2 years; range, 0.2-27) underwent liver biopsy, gastroscopy, abdominal ultrasound, and laboratory tests. Sixteen patients were on parenteral nutrition (PN) after 74 PN months (range, ...
Li Jun - - 2013
Phytochemical investigation of the leaves of Cecropia schreberiana Miq. (Urticaceae) led to the isolation of four triterpenoids (1-4), three flavone C-glycosides (5-7), two flavan-3-ols (8, 9), two flavanolignans (10, 11), and two proanthocyanidins (12, 13). All compounds were isolated from C. schreberiana for the first time. This is the first ...
Sahin Melisa M Division of Nephrology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, - - 2013
Nephrotic syndrome (NS) may occur with acquired hypercoagulability, however, the fact that it is accompanied by an underlying hereditary thrombophilia, especially combined hereditary thrombophilia would lead to thrombotic events. In this study, we aimed to evaluate the contribution of genetic thrombophilia to development of thrombotic events in adult patients with ...
Kapoor Sabrina R SR University of Birmingham and the Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, - - 2013
Anti-tumor necrosis factor (anti-TNF) therapies are highly effective in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), but a significant number of patients exhibit only a partial or no therapeutic response. Inflammation alters local and systemic metabolism, and TNF plays a role in this. We undertook this study to determine if ...
Green Scott R SR Center for Wireless Integrated MicroSensing and Systems, Ann Arbor, MI, USA. - - 2013
This paper presents the in vivo and in situ evaluation of a system that wirelessly monitors the accumulation of biliary sludge in a plastic biliary stent. The sensing element, located within the stent, is a passive array of magnetoelastic resonators that is queried by a wireless electromagnetic signal. The in ...
Navarro-Millán Iris I University of Alabama at Birmingham, Birmingham, AL 35294, - - 2013
To study changes in lipid profiles at 24 weeks among patients with early rheumatoid arthritis (RA) participating in the Treatment of Early RA (TEAR) trial and randomized to receive methotrexate (MTX) plus etanercept, triple therapy (MTX plus sulfasalazine plus hydroxychloroquine), or aggressively titrated MTX monotherapy. This TEAR substudy included 459 ...
Long David L DL Wake Forest University School of Medicine, Winston-Salem, NC 27157, - - 2013
Matrix fragments, including fibronectin (FN) fragments, accumulate during the development of osteoarthritis (OA), stimulating the production of chondrocyte matrix metalloproteinase (MMP). The objective of this study was to determine the role of the small GTPase Rac1 in chondrocyte signaling stimulated by FN fragments, which results in MMP-13 production. Normal human ...
Chu Po-Sung PS Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, - - 2013
Chemokine receptors mediate migration of immune cells into the liver, thereby promoting liver inflammation. C-C motif chemokine receptor (CCR) 9(+) macrophages are crucial in the pathogenesis of acute liver inflammation, but the role and underlying mechanisms of this macrophage subset in chronic liver injury and subsequent liver fibrosis are not ...
Nace Gary W GW Department of Surgery, University of Pittsburgh, Pittsburgh, - - 2013
Ischemia-reperfusion (I/R) injury is a process whereby an initial hypoxic insult and subsequent return of blood flow leads to the propagation of innate immune responses and organ injury. The necessity of the pattern recognition receptor, Toll-like receptor (TLR)4, for this innate immune response has been previously shown. However, TLR4 is ...
Satoskar Rohit R Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC, USA. - - 2013
Healthcare guidelines and recommendations have broad-reaching impact. They serve as the evidence to enforce medical testing by establishing a bar for standard of care through their intrinsic credibility but also by affecting reimbursement. In this article, we discuss the various organizations in the United States that develop healthcare policy and ...
Wang Yi-Wei YW Institute of Biomedical Sciences, Academia Sinica, Taipei, - - 2013
Eukaryotic translation initiation factor 3 subunit I (eIF3I) with transforming capability is often overexpressed in human hepatocellular carcinoma (HCC) but its oncogenic mechanisms remain unknown. We demonstrate that eIF3I is overexpressed in various cancers along with activated Akt1 phosphorylation and kinase activity in an eIF3I dose-dependent manner. A novel eIF3I ...
Deyo Richard A RA Department of Family Medicine, Center for Research on Occupational and Environmental Toxicology, Portland, OR, USA. - - 2013
Cross-sectional analysis of electronic medical and pharmacy records. To examine associations between use of medication for erectile dysfunction or testosterone replacement and use of opioid therapy, patient age, depression, and smoking status. Males with chronic pain may experience erectile dysfunction related to depression, smoking, age, or opioid-related hypogonadism. The prevalence ...
Berry Sarah D SD Institute for Aging Research, Hebrew SeniorLife, and Harvard Medical School, Boston, MA 02131, USA. - - 2013
It is important to understand the relationship between sleep medication use and injurious falls in nursing home residents. To conduct a case-crossover study to estimate the association between nonbenzodiazepine hypnotic drug use (zolpidem tartrate, eszopiclone, or zaleplon) and the risk for hip fracture among a nationwide sample of long-stay nursing ...
Tong Leung Chu - - 2013
Rare studies have reported the application of multiple ancillary tests to the diagnosis of lymphoproliferative disorder in serous effusions. In the current study, the authors evaluated the effectiveness of using an algorithm for the triage of serous effusions and the contribution of ancillary studies to achieve a specific subtype of ...
Doherty Karen M KM Reta Lila Weston Institute for Neurological Studies, University College London, London, - - 2013
Mutations in the gene encoding parkin (PARK2) are the most common cause of autosomal recessive juvenile-onset and young-onset parkinsonism. The few available detailed neuropathologic reports suggest that homozygous and compound heterozygous parkin mutations are characterized by severe substantia nigra pars compacta neuronal loss. To investigate whether parkin-linked parkinsonism is a ...
Mussman Grant M GM Divisions of Hospital Medicine, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA. - - 2013
Hospitalizations of infants for bronchiolitis are common and costly. Despite the high incidence and resource burden of bronchiolitis, the mainstay of treatment remains supportive care, which frequently includes nasal suctioning. To examine the association between suctioning device type and suctioning lapses greater than 4 hours within the first 24 hours ...
Beukelman Timothy T University of Alabama at Birmingham, Division of Pediatric Rheumatology, Birmingham, AL 35233-1711, USA. - - 2013
To compare incidence rates of selected opportunistic infections among children with and children without juvenile idiopathic arthritis (JIA). Using U.S. national Medicaid administrative claims data from 2000 through 2005, we identified a cohort of children with JIA based on physician diagnosis codes and dispensed medications. We also identified a non-JIA ...
Hoffmann Joseph C JC Department of Bioengineering, MS-142, Rice University, 6100 Main Street, Houston, Texas 77005, USA. - - 2013
In order to independently study the numerous variables that influence cell movement, it will be necessary to employ novel tools and materials that allow for exquisite control of the cellular microenvironment. In this work, we have applied advanced 3D micropatterning technology, known as two-photon laser scanning lithography (TP-LSL), to poly(ethylene ...
Payne Allison H AH Departments of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western ReserveUniversity, Cleveland, OH 44106, USA. - - 2013
Low-grade periventricular-intraventricular hemorrhage is a common neurologic morbidity among extremely low-gestational-age neonates, yet the outcomes associated with this morbidity are not fully understood. In a contemporary multicenter cohort, we evaluated the impact of such hemorrhages on early (18-22 month) neurodevelopmental outcomes of extremely premature infants. To compare neurodevelopmental outcomes at ...
Freiberg Matthew S MS University of Pittsburgh School ofMedicine, Pittsburgh, PA 15213, USA. - - 2013
Whether people infected with human immunodeficiency virus (HIV) are at an increased risk of acute myocardial infarction (AMI) compared with uninfected people is not clear. Without demographically and behaviorally similar uninfected comparators and without uniformly measured clinical data on risk factors and fatal and nonfatal AMI events, any potential association ...
Bode Ann M AM The Hormel Institute, University of Minnesota, Austin, MN 55912, - - 2013
Diet exerts a major influence on the risk for developing cancer and heart disease. Food factors such as flavonoids are alleged to protect cells from premature aging and disease by shielding DNA, proteins, and lipids from oxidative damage. Our work has focused on clarifying the effects of dietary components on ...
Zhu Zaifang Z Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, - - 2013
We report a novel approach for effectively separating DNA molecules in free solution. The method uses a bare narrow open capillary without any sieving matrices to resolve a wide size-range of DNA fragments at efficiencies of more than a million plates per meter routinely.
Maggio Marcello - - 2013
The use of proton pump inhibitors (PPIs) has rapidly increased during the past several years. However, concern remains about risks associated with their long-term use in older populations. To investigate the relationship between the use of PPIs and the risk of death or the combined end point of death or ...
Wright Jason D - - 2013
Although febrile neutropenia (FN) is a major source of morbidity and mortality for patients with solid tumors, little is known about the use of guideline-based care. To examine compliance with guideline-based recommendations for FN treatment, explore the factors that influence adherence to consensus guidelines, and analyze how the use of ...
Orr William C WC Department of Biological Sciences, Southern Methodist University, Dallas, Texas 75275, USA. - - 2013
The main objective of this review was to provide an exposition of investigations, conducted in Drosophila melanogaster, on the role of reactive oxygen species and redox state in the aging process. While early transgenic studies did not clearly support the validity of the oxidative stress hypothesis of aging, predicated on ...
Akbari M R MR Women's College Research Institute, Women's College Hospital, University of Toronto, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, - - 2014
We sought to identify the full range of founder mutations in BRCA1 and BRCA2 in the Bahamas and to estimate the proportion of all BRCA1 and BRCA2 mutations that are accounted for by founder mutations. We studied 214 Bahamian women with invasive breast cancer, unselected for age or family history. ...
Corona Giulia G 1 Molecular Nutrition Group, Centre for Integrative Neuroscience and Neurodynamics, School of Chemistry, Food and Pharmacy, University of Reading , Reading, United Kingdom - - 2013
While much data exist for the effects of flavonoid-rich foods on spatial memory in rodents, there are no such data for foods/beverages predominantly containing hydroxycinnamates and phenolic acids. To address this, we investigated the effects of moderate Champagne wine intake, which is rich in these components, on spatial memory and ...
Boix Macarena - - 2013
Accurate image segmentation is used in medical diagnosis since this technique is a noninvasive pre-processing step for biomedical treatment. In this work we present an efficient segmentation method for medical image analysis. In particular, with this method blood cells can be segmented. For that, we combine the wavelet transform with ...
Park Ji-Hye - - 2013
Segmental vitiligo (SV) is usually characterized by a unilateral-dermatomal distribution, earlier onset and rapid progression followed by stabilization. The response to phototherapy in patients with SV is limited. We evaluated the treatment response in 39 cases of SV according to disease duration. Ten cases (50.0%) of Group 1 (duration ≤ 5 months) ...
Ergen Elizabeth N - - 2013
Porphyria cutanea tarda (PCT) is a disease caused by a deficiency of the fifth enzyme of the heme biosynthetic pathway in the liver that manifests in the skin as blistering and fragility of predominantly sun-exposed skin. It occurs in individuals with environmental and/or genetic risk factors such as estrogen use, ...
Heo Moonseong - - 2013
In longitudinal cluster randomized clinical trials (cluster-RCT), subjects are nested within a higher level unit such as clinics and are evaluated for outcome repeatedly over the study period. This study design results in a three level hierarchical data structure. When the primary goal is to test the hypothesis that an ...
Xiao Yanyu - - 2013
In this paper, we modify the classic Ross-Macdonald model for malaria disease dynamics by incorporating latencies both for human beings and female mosquitoes. One novelty of our model is that we introduce two general probability functions (P (t) and P (t)) to reflect the fact that the latencies differ from ...
Gilbert Robert P - - 2013
A one-dimensional model for the transport of vitamin D3 in an osteoblast cell is proposed, from its entry through the membrane to its activation of RANKL synthesis in the nucleus. In the membrane and cytoplasm, the transport of D3 and RANKL is described by a diffusion process, while their interaction ...
Karadag Ayse Serap - - 2013
Eczematid-like purpura of Doucas and Kapetanakis is a type of pigmented purpuric dermatoses (PPDs) with eczematous changes in the purpuric surface. A 10-year-old male and a 44-year-old male patients were admitted to our clinics for itching and flaking of the skin rashes. Based on the clinical and histopathological evaluations, the ...
Ye Chang-Ming - - 2013
The Potato virus X (PVX) triple gene block protein 3 (TGBp3), an 8-kDa membrane binding protein, aids virus movement and induces the unfolded protein response (UPR) during PVX infection. TGBp3 was expressed from the Tobacco mosaic virus (TMV) genome (TMV-p3), and we noted the up-regulation of SKP1 and several endoplasmic ...
Yuan Zhaohui - - 2013
We consider a mathematical model that describes the interactions of the HIV virus, CD4 cells and CTLs within host, which is a modification of some existing models by incorporating (i) two distributed kernels reflecting the variance of time for virus to invade into cells and the variance of time for ...
Martinez Alexa - - 2013
The purpose of these clinical trials was to determine if 300 W and 150 W xenon arc solar simulators (SSs) deliver the same sun protection factor (SPF) and UVA protection factor (PFA). First, the SPF of the P7 control standard and of the P2 control standard was determined, testing 20 subjects using ...
Gonzalez-Olivares Eduardo - - 2013
The main purpose of this work is to analyze a Gause type predator-prey model in which two ecological phenomena are considered: the Allee effect affecting the prey growth function and the formation of group defence by prey in order to avoid the predation. We prove the existence of a separatrix ...
Mei Xingyu - - 2013
The success rates of conventional treatments to acne vulgaris are limited because of intolerance and resistance. Photodynamic therapy with topical 5-aminolevulinic acid (ALA) and red light has been introduced. However, the side effects especially pigmentation are common. To study the efficacy and safety of ALA-photodynamic therapy (PDT) with 420-950 nm intense ...
Song Jae Hyoung - - 2013
Mangifera indica L. (Anacardiaceae) is a medicinal plant whose extracts have been described as an antioxidant with anti-inflammatory and immunomodulatory activities. Skin aging is a consequence of chronic sun exposure to the sun and therefore ultraviolet (UV) radiation. Naturally occurring antioxidants are known to reduce skin aging. Therefore, the aim ...
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