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Gomes Marco Tulio R - - 2013
Pathogens are detected by innate immune receptors that, upon activation, orchestrate an appropriate immune response. Recent studies revealed the intracellular signaling cascades involved in the TLR-initiated immune response to Brucella abortus infection. However, no report has elucidated the role of inflammasome receptors in Brucella recognition. Therefore, we decided to investigate ...
Turan Suslu H - - 2013
Background. A neurosurgical laboratory training model is designed for trainees in microneurosurgery to learn to handle surgical microscopes and microneurosurgical instruments. The silicone injection of a fresh cadaveric cow cranium is an alternative to using a cadaveric human brain for becoming familiar with the cerebellopontine angle (CPA) via the retrosigmoid ...
Shoemaker Kevin T KT Department of Environmental and Forest Biology, State University of New York College of Environmental Science and Forestry, Syracuse, NY 13210, USA. - - 2013
For decades conservation biologists have proposed general rules of thumb for minimum viable population size (MVP); typically, they range from hundreds to thousands of individuals. These rules have shifted conservation resources away from small and fragmented populations. We examined whether iteroparous, long-lived species might constitute an exception to general MVP ...
Song Zhongchen Z Department of Periodontology, Ninth People's Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, - - 2013
Cleft palate represents one of the most common congenital birth defects in humans. TGFβ signaling, which is mediated by Smad-dependent and Smad-independent pathways, plays a crucial role in regulating craniofacial development and patterning, particularly in palate development. However, it remains largely unknown whether the Smad-independent pathway contributes to TGFβ signaling ...
Myrskylä Mikko - - 2013
BACKGROUND: The German East-West mortality difference narrowed rapidly after the 1990 unification, particularly for women. We analyse recent trends for women aged 50-89 years and document for the first time lower mortality in the East. We study how smoking contributes to this cross-over. METHODS: We analyse mortality by cause for ...
Wang Hua - - 2013
Abstract Effective therapeutic strategies for radiation-induced lung injury (RILI) are lacking. Mesenchymal stem cells (MSCs), as gene therapy delivery vehicles, possess the ability to repair injured lung. In this study, we conducted MSC-based hepatocyte growth factor (HGF) gene therapy for RILI. Mice received single-dose radiation with 20 Gy of γ rays ...
Cebrian-Serrano A - - 2013
Melatonin may play an important role in protecting gametes and embryos from the potential harmful effects of oxidative stress. In this study, we first examined two different heat stress (HS) treatments for in vitro oocyte maturation (Experiment 1: 38.5 vs 41.0°C, during the first 20 h; Experiment 2: 38.5 vs 41.5°C, ...
Thorn R M S - - 2013
The main aim of this study was to develop a standardized experimental assay to enable differential antimicrobial comparisons of test biocidal aerosols. This study represents the first chlorine-matched comparative assessment of the antimicrobial activities of aerosolized sodium hypochlorite, chlorine dioxide, and electrochemically activated solution (ECAS) to determine their relative abilities ...
Saw Wuan Geok - - 2013
The glycosylphosphatidylinositol (GPI) transamidase complex catalyzes the attachment of GPI anchors to eukaryotic proteins in the lumen of endoplasmic reticulum. The Saccharomyces cerevisiae GPI transamidase complex consists of the subunits yPIG-K (Gpi8p), yPIG-S (Gpi17p), yPIG-T (Gpi16p), yPIG-U (CDC91/GAB1) and yGPAA1. We present the production of the two recombinant proteins yGPAA170-247 ...
Dishman Rod K RK The University of Georgia, Athens, GA, USA. - - 2013
Scales used to measure selected social-cognitive beliefs and motives for physical activity were tested among boys and girls. Covariance modeling was applied to responses obtained from large multi-ethnic samples of students in the fifth and sixth grades. Theoretically and statistically sound models were developed, supporting the factorial validity of the ...
Song Jeong Eun - - 2013
Demineralized bone particle (DBP), which is widely used as a biomaterial in the field of tissue engineering, contains various bioactive molecules, such as cytokines. For this reason, in this study we investigated the effects of injectable DBP gels on cell proliferation, inflammation and maintenance of the shape of DBP gels ...
Herráez David López - - 2013
OBJECTIVE: Identify susceptibility loci for rheumatoid arthritis (RA) in Latin American individualswith admixed European and Amerindian genetic ancestry. METHODS: Genotyping was performed on samples from 1475 patients with RA and 1213 controls using a custom BeadArray containing196,524 markers, covering loci previously associated with various autoimmune diseases. We used principal component ...
Gupta Neelam - - 2013
Abstract Background: Approximately two-thirds of patients who die in the pediatric intensive care unit (PICU) do so following withdrawal of intensive care treatment. Most often when intensive care treatment is withdrawn, the child remains in the PICU for end-of-life care. Objectives: This study aimed to examine the process of referral ...
Duncan Elizabeth M - - 2013
In recent years, there has been greater awareness among hemostasis scientists and clinicians that factor VIII coagulant activity (FVIII:C) measured in certain patients with mild hemophilia A can show different results depending on the assay system. A subgroup of mild hemophilia families have a method-related discrepancy in FVIII:C results, whereby ...
Ward Claire E - - 2013
Newborn screening for severe combined immunodeficiency (SCID) is currently being performed in many states. It is important to address diagnostic challenges while outcomes are emerging from the first several years of screening. We present the case of a premature infant whose initial newborn screen was strongly positive for SCID. Subsequent ...
Kline Alex J AJ Three Rivers Orthopedics, Pittsburgh, PA, - - 2013
The optimal method for treating intra-articular fractures of the calcaneus remains controversial. Extensile approaches allow excellent fracture exposure, but high rates of wound complications are seen. Newer minimally invasive techniques for calcaneus fracture fixation offer a potentially lower wound complication rate, but long-term clinical results are not available. The aim ...
Khatun Mansura - - 2013
Ten quaternary arsenides AM1.5Tt0.5As2 (A = Na, K, Rb; M = Zn, Cd; Tt = Si, Ge, Sn) have been prepared by stoichiometric reactions of the elements at 600-650 °C. Seven of them (NaZn1.5Si0.5As2, NaZn1.5Ge0.5As2, NaZn1.5Sn0.5As2, NaCd1.5Sn0.5As2, KZn1.5Sn0.5As2, KCd1.5Sn0.5As2, RbCd1.5Sn0.5As2) adopt the trigonal CaAl2Si2-type structure (Pearson symbol hP5, space group ...
Bolman Maya - - 2013
Milk expression is a normal part of breastfeeding, but in developed countries in particular, the focus tends to center on mechanical expression. In Russia, there is a long tradition of hands-on techniques that continues in the present day and includes mothers turning to providers trained in hand expression and breast ...
Gandor Silke - - 2013
Taking the bait: Protein interaction arrays were generated in living cells by the interaction of bait-presenting artificial receptor constructs (bait-PARCs) with micrometer-scaled antibody surface patterns. This method was applied to simultaneously monitor the interaction kinetics of a prey protein with two distinct bait proteins in individual living cells.
Djalali Alimorad G - - 2013
BACKGROUND:Ephedrine is a direct/indirect vasoactive drug. In addition, it also possesses intrinsic local anesthetic properties, mainly due to its sodium-channel blockage. We investigated whether ephedrine demonstrates a synergistic effect with bupivacaine and lidocaine when injected via a spinal catheter into the spinal space of rats.METHODS:Spinal catheters were surgically placed in ...
Koneczny Inga - - 2013
MuSK myasthenia gravis is a rare, severe autoimmune disease of the neuromuscular junction, only identified in 2001, with unclear pathogenic mechanisms. In this review we describe the clinical aspects that distinguish MuSK MG from AChR MG, review what is known about the role of MuSK in the development and function ...
Paulot Fabien - - 2013
Anthropogenic enrichment of reactive nitrogen (Nr) deposition is an ecological concern. We use the adjoint of a global 3-D chemical transport model (GEOS-Chem) to identify the sources and processes that control Nr deposition to an ensemble of biodiversity hotspots worldwide and two US national parks (Cuyahoga and Rocky Mountain). We ...
Singh Mahi R - - 2013
We have investigated the second-harmonic generation (SHG) and dipole-dipole interaction in a quantum dot and metallic nanoparticle hybrid system. A strong probe field is applied to create two-photon absorption in the quantum dot and metallic nanoparticle. SHG photons and SHG surface plasmon polaritons are emitted by the quantum dot and ...
Dai Lue - - 2013
The susceptibility of macrophages to HIV-1 infection is modulated during monocyte differentiation. IL-27 is an anti-HIV cytokine that also modulates monocyte activation. In this study, we present new evidence that IL-27 promotes monocyte differentiation into macrophages that are nonpermissive for HIV-1 infection. Although IL-27 treatment does not affect expression of ...
Price David - - 2013
BACKGROUND: Patient preference is an important factor when choosing an inhaler device for asthma or chronic obstructive pulmonary disease (COPD). AIMS: To identify characteristics of patients with asthma or COPD who prefer a once-daily controller medication regimen. METHODS: This retrospective observational study used electronic patient records and linked outcomes from ...
Urbina Elaine M EM Preventive Cardiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC-7002, Cincinnati, OH 45229, USA. - - 2013
Lipid levels are linked to early atherosclerosis. Risk stratification may be improved by using triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C), which relates to arterial stiffness in adults. We tested whether TG/HDL-C was an independent predictor of arterial stiffness in youth. Subjects 10 to 26 years old (mean 18.9 years, ...
Golebiewska Anna - - 2013
The identification and significance of cancer stem-like cells in malignant gliomas remains controversial. It has been proposed that cancer stem-like cells display increased drug resistance, through the expression of ATP-binding cassette transporters that detoxify cells by effluxing exogenous compounds. Here, we investigated the 'side population' phenotype based on efflux properties ...
Zhang X - - 2013
One of the challenging skills in golfing is the driver swing. There have been a large number of studies characterizing golf swings, yielding insightful instructions on how to swing well. As a result, achieving a sub-18 handicap is no longer the top problem for golfers. Instead, players are now most ...
Moerman Annelies - - 2013
BACKGROUND:In this study, we compared the effects of 3 frequently used arterial blood pressure-regulating agents on brain (rScO2), renal (SrO2), and muscle (SmO2) oxygen saturation, during aortic coarctation repair in children. Based on the reported adverse effect of sodium nitroprusside (SNP) on left-sided rScO2 during aortic coarctation repair, we tested ...
Minsky Burcu Baykal - - 2013
The electropherogram of native heparin shows a broad distribution of mobilities µ which truncates abruptly at a notably high µ = 4.7x10-4 cm2V-1s-1. This highly skewed mobility distribution is also found for the 20-saccharide chain which shows from mass spectrometry a more uniform (symmetrical) with respect to sulfation level. Since ...
Mandelbaum Eric - - 2013
The idea that there is a "Number Sense" (Dehaene, 1997) or "Core Knowledge" of number ensconced in a modular processing system (Carey, 2009) has gained popularity as the study of numerical cognition has matured. However, these claims are generally made with little, if any, detailed examination of which modular properties ...
Wilt Timothy J - - 2013
IMPORTANCE Restless legs syndrome (RLS) is a neurological disorder characterized by unpleasant sensations in the legs and a distressing, irresistible urge to move them. We conducted a systematic review to evaluate efficacy, safety, and comparative effectiveness of pharmacologic treatments for primary RLS. EVIDENCE ACQUISITION We included randomized controlled trials (RCTs), ...
Hackman Lucina - - 2013
This study examines the reliability of age estimation utilizing the Pyle and Hoerr atlas in relation to a modern Scottish population. The knee radiographs of 442 individuals (168 females, 274 males) were age assessed using the Pyle and Hoerr atlas. Analysis showed that there was a strong correlation between chronological ...
Silva Christopher J - - 2013
We employed a sensitive mass spectrometry-based method to deconstruct, confirm and quantitate the prions present in elk naturally infected with chronic wasting disease and sheep naturally infected with scrapie. We used this approach to study the oxidation of a methionine at position 216 (Met216), since this oxidation (MetSO216) has been ...
Ogle Christin M - - 2013
The present study examined the impact of the developmental timing of trauma exposure on posttraumatic stress disorder (PTSD) symptoms and psychosocial functioning in a large sample of community-dwelling older adults (N = 1,995). Specifically, we investigated whether the negative consequences of exposure to traumatic events were greater for traumas experienced ...
Degidi Marco - - 2013
PURPOSE: The aim of this trial was to assess if the nonremoval of abutments placed at the time of surgery would improve bone and gingival healing around single immediately restored implants placed in postextraction sockets. MATERIALS AND METHODS: All patients received a single square-threaded tapered implant placed in postextraction sockets ...
Maggi Umberto - - 2013
Venous thrombosis can complicate inflammatory bowel diseases, both in adult and pediatric patients, and a few adult cases of thrombotic storm, ie, thrombosis at multiple sites occurring over a period of a few days to a few weeks, have been described. However, venous thrombosis as the first manifestation of an ...
Anderson Moji - - 2013
Research has shown that living with sickle cell disease (SCD) can be a considerable challenge. Unfortunately, although it is Jamaica's most common genetic disorder, to date, no qualitative research has been conducted on Jamaicans' experiences of SCD. We conducted thematic analysis on transcripts of in-depth semistructured interviews with 30 patients ...
Rao Neeta - - 2013
Summary Studies among migrants show that they are more susceptible to HIV infection than the general population and thereby spread the epidemic from high prevalence to low prevalence areas. It is therefore critical to enhance the body of knowledge on factors associated with condom use among migrants. This study, conducted ...
Qaisar Rizwan R Department of Neuroscience, Clinical Neurophysiology, Uppsala University, - - 2013
Ageing is associated with a decline in muscle mass and strength leading to increased physical dependency in old age. Postmenopausal women experience a greater decline than men of similar age in parallel with the decrease in female sex steroid hormone production. We recruited six monozygous female twin pairs (55-59 years ...
Reddy Kavitha K - - 2013
BACKGROUND: Infantile hemangioma (IH) clearance may be slow or incomplete in response to pulsed dye laser (PDL) or propranolol alone. OBJECTIVES: To evaluate whether IH treated with PDL and propranolol displayed more rapid and complete clearance than IH treated with propranolol alone. MATERIALS AND METHODS: Retrospective review of facial-segmental IH ...
Wang Lin - - 2013
ObjectiveTo explore the feasibility and efficacy of Z-palatoplasty for the management of severe obstructive sleep apnea-hypopnea syndrome in patients with tonsils.Study DesignCase series and chart review.SettingUniversity hospital.MethodsZ-palatoplasty and coblation channeling of the tongue were performed in 36 patients with body mass index <40 kg/m2 and size 1 or 2 tonsils. ...
Maity Soumya - - 2013
The antioxidant property of the 70% aqueous ethanol extract of Phyllanthus amarus roots and its ether-soluble, ethyl acetate-soluble and aqueous fractions were investigated by various in vitro assays. The root extracts showed higher DPPH, hydroxyl, superoxide, and nitric oxide radical scavenging, and reducing power activity. Among all the samples, ethyl ...
Wong D M - - 2013
BACKGROUND: Renal replacement therapy (RRT) has been implemented extensively in people to facilitate recovery from acute renal failure (ARF). RRT has not been explored in horses, but might provide a further treatment option in horses with ARF. OBJECTIVE: To investigate efficacy and safety of RRT in horses. ANIMALS: Five healthy ...
Spear Shawn - - 2013
Background: In 2009, the Society of Critical Care Medicine (SCCM)/American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) published "Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient." To improve our surgery residents' understanding of intensive care unit (ICU) nutrition, we developed a nutrition ...
Noh Seung-Kyun - - 2013
The role of halogen bonds in self-assembled networks for systems with Br and I ligands has recently been studied with scanning tunneling microscopy (STM), which provides physical insight at the atomic scale. Here, we study the supramolecular interactions of 1,5-dichloroanthraquinone molecules on Au(111), including Cl ligands, by using STM. Two ...
Branigan Steven - - 2013
Disk imaging involves copying all of the data from a source disk drive to a target. Typically, the target for the copy is another disk drive. Forensic processes developed years ago do not appear to be adequate for current storage technology. For example, with disk drive capacities now exceeding 1 ...
Butet Jérémy - - 2013
Second harmonic generation from plasmonic nanoantennas is investigated numerically using a surface integral formulation for the calculation of both the fundamental and the second harmonic electric field. The comparison between a realistic and an idealized gold nanoantenna shows that second harmonic generation is extremely sensitive to asymmetry in the nanostructure ...
Tittl Andreas - - 2013
Locally probing chemical reactions or catalytic processes on surfaces under realistic reaction conditions has remained one of the main challenges in materials science and heterogeneous catalysis. Where conventional surface interrogation techniques usually require high-vacuum conditions or ensemble average measurements, plasmonic nanoparticles excel in extreme light focusing and can produce highly-confined ...
Fu Qiang - - 2013
Heterogeneous catalysts, often consisting of metal nanoparticles supported on high-surface-area oxide solids, are common in industrial chemical reactions. Researchers have increasingly recognized the importance of oxides in heterogeneous catalysts: that they are not just a support to help the dispersion of supported metal nanoparticles, but rather interact with supported metal ...
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