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Results 301 - 350 of 5164
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Mizerska-Dudka Magdalena - - 2013
The influence of infection with an entomopathogenic strain of Pseudomonas aeruginosa on Galleria mellonella hemocytes was investigated. Extensive bacteriaemia developed 18 h after infection. This was correlated with significant changes in morphology, viability and the spreading ability of immunocompetent hemocytes, namely granulocytes and plasmatocytes. Since bacteriaemia developed, membrane blebbing, cytoplasm vacuolization, ...
Aravindan Sheeja - - 2013
BACKGROUND: Heterogeneously distributed hypoxic areas are a characteristic property of locally advanced breast cancers (BCa) and generally associated with therapeutic resistance, metastases, and poor patient survival. About 50% of locally advanced BCa, where radiotherapy is less effective are suggested to be due to hypoxic regions. In this study, we investigated ...
Chan Zenobia Cy - - 2013
AIMS AND OBJECTIVES: To explore students' attitude towards problem-based learning, creativity and critical thinking, and the relevance to nursing education and clinical practice. BACKGROUND: Critical thinking and creativity are crucial in nursing education. The teaching approach of problem-based learning can help to reduce the difficulties of nurturing problem-solving skills. However, ...
Rofouie M K - - 2013
Comparative molecular field analysis (CoMFA), comparative molecular field analysis region focusing (CoMFA-RF) for optimizing the region for the final partial least square analysis, and comparative molecular similarity indices analysis (CoMSIA) methods were employed to develop three-dimensional quantitative structure-activity relationship (3D-QSAR) models of 1 H NMR chemical shift of NH proton ...
Yeo Sang Chul - - 2013
We report first-principles calculations of adsorption, dissociation, penetration, and diffusion for the complete nitridation mechanism of nitrogen molecules on a pure Fe surface (bcc, ferrite phase). The mechanism of the definite reaction path was calculated by dividing the process into four steps. We investigated various reaction paths for each step ...
Li Xinlei - - 2013
We have presented a theoretical model to elucidate the formation mechanisms of quantum dots (QDs) on patterned substrates, which introduced the perspective that the preferred formation site of QDs is determined by the nonuniformity of wetting layer thickness caused by surface potential. Two different preferred formation sites, low surface curvature ...
Webber James T - - 2013
The use of mass spectrometry for characterization of small molecules, nucleotides, and proteins in model organisms as well as primary tissues and clinical samples continues to proliferate at a rapid pace. The complexity and dynamic range of target analytes in biological systems hinders comprehensive analysis and simultaneously drives improvements in ...
Festa Fernanda - - 2013
The study of protein function usually requires the use of a cloned version of the gene for protein expression and functional assays. This strategy is particular important when the information available regarding function is limited. The functional characterization of the thousands of newly identified proteins revealed by genomics requires faster ...
Hogl Sebastian - - 2013
The aspartyl protease BACE1 cleaves neuregulin 1 and is involved in myelination and is a candidate drug target for Alzheimer's disease, where it acts as the β-secretase cleaving the amyloid precursor protein (APP). However, little is known about other substrates in vivo. Here, we provide a proteomic workflow for BACE1 ...
Hailemariam Z - - 2013
Bovine cysticercosis causing damage to the beef industry is closely linked to human taeniasis due to Taenia saginata. In African countries, Taenia spp. from wildlife are also involved as possible sources of infections in livestock. To identify the aetiological agents of bovine cysticercosis in Ethiopia, cysticerci were collected from 41 ...
Metcalf J L - - 2013
DNA repair is essential for maintaining genomic stability, and defects in this process significantly increase the risk of cancer. Clear-cell renal cell carcinoma (CCRCC) caused by inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene is characterized by high genomic instability. However, the molecular mechanism underlying the association between the ...
Horiuchi Hiroshi - - 2013
Abstract Background and study aim. Although focal cancer occasionally coexists with gastric hyperplastic polyps, previous studies have reported that white light endoscopy (WLE) and biopsy sampling cannot effectively predict the coexistence of cancer. The aim of this study was to elucidate efficacious predictors for cancer coexistence. Patients and methods. This ...
Arnold Polly L - - 2013
The heterobimetallic complexes [{UO2Ln(py)2(L)}2], combining a singly reduced uranyl cation and a rare-earth trication in a binucleating polypyrrole Schiff-base macrocycle (Pacman) and bridged through a uranyl oxo-group, have been prepared for Ln = Sc, Y, Ce, Sm, Eu, Gd, Dy, Er, Yb, and Lu. These compounds are formed by the ...
Altorf-van der Kuil Wieke - - 2013
In the present controlled, randomised, multiple cross-over dietary intervention study, we aimed to identify potential biomarkers for dietary protein from dairy products, meat and grain, which could be useful to estimate intake of these protein types in epidemiological studies. After 9 d run-in, thirty men and seventeen women (22 (sd 4) ...
Shimozono Yoko - - 2013
The number of conformers and their structures of tyrosine are reassigned on the basis of resonance enhanced multiphoton ionization (REMPI), ultraviolet-ultraviolet hole burning (UV-UV HB), infrared (IR) dip spectra, and quantum chemical calculations. From comparison between REMPI and UV-UV HB spectra, it was found that 12 conformers coexist in the ...
Kurjak Asim - - 2013
Abstract Aim. The aim was to assess the onset and the frequencies of the first intertwin contacts by four dimensional ultrasound (4D US) in the 1st trimester of pregnancy. In the second part of the study fetal behavior and Kurjak Antenatal Neurodevelopmental Test (KANET) score of twins compared to singletons ...
Hoffman Kevin W - - 2013
The amino acid histidine (His) has a number of unique roles that can dictate function in proteins, and these roles are typically conferred through noncovalent interactions that depend on the protonation state of His's 4-substituted imidazole ring. His's protonation state can vary near physiological pH, and a probe of His's ...
Song Guoxin - - 2013
A method based on dispersive liquid-liquid microextraction coupled with GC/MS was developed for quantitative analysis of the major organic pollutants listed in USEPA method 8270 and the 15 European-priority PAHs in coking wastewater. The major parameters such as extraction solvent, dispersive solvent, solution pH, and extraction time were systematically optimized. ...
Sah Raman Prasad - - 2013
We present an interesting case of a child with Marfan's syndrome with ectopia lentis, who was followed for five years. The changes in refractive and visual findings of this child during this period are discussed. The importance of careful oculo-visual examination and possible management options in such children are highlighted.
Kan-O Keiko - - 2013
BACKGROUND: Clinical studies showed the contribution of viral infection to the development of asthma. Although mast cells have multiple roles in the pathogenesis of allergic asthma, their role of in the virus-associated pathogenesis of asthma remains unknown. Most respiratory viruses generate double-stranded (ds) RNA during their replication. dsRNA provokes innate ...
Schwenkglenks Matthias - - 2013
ABSTRACT Febrile neutropenia (FN) is a common and serious complication of chemotherapy treatment. Clinical risk models may help identify high risk FN patients but must undergo external validation before implementation in medical practice. Therefore, this study externally validated previously published clinical models of FN occurrence during chemotherapy in 240 non-Hodgkin ...
French Amanda N - - 2013
PURPOSE: To examine the patterns of myopigenic activity (high near work, low time outdoors) in children growing up in Sydney, Australia, by age, ethnicity and gender. METHODS: The Sydney Adolescent Vascular and Eye Study (SAVES) re-examined children from the two age cohorts (6 and 12 years at baseline) from the Sydney ...
Fairbrother Peter - - 2013
AIMS AND OBJECTIVES: To understand the views of patients and professionals on the acceptability and perceived usefulness of telemonitoring in the management of chronic heart failure in the context of day-to-day care provision. BACKGROUND: There is an increasing interest in the potential for telemonitoring to support the home-based management of ...
Bisson Patrick J - - 2013
The prism face of single crystal ice Ih has been studied using sum frequency vibrational spectroscopy focusing on identification of resonances in the hydrogen-bonded region. Several modes have been observed at about 3400 cm-1; each mode is both polarization and orientation dependent. The polarization capabilities of sum frequency generation (SFG) ...
Zoanetti Nathan - - 2013
BACKGROUND: Despite the widespread use of multiple-choice assessments in medical education assessment, current practice and published advice concerning the number of response options remains equivocal. This article describes an empirical study contrasting the quality of three 60 item multiple-choice test forms within the Royal Australian and New Zealand College of ...
He Zhangzhen - - 2013
K4Fe4P5O20 shows an interesting natrolite-like structure with a spin-tetrahedron lattice built by mixed valence Fe ions. Single crystals of the title compound are successfully grown by the flux method using KF as flux. Magnetic results combined from magnetic, heat capacity, and 57Fe Mössbauer spectra measurements show that K4Fe4P5O20 possesses a ...
Kim Dong Wook - - 2013
Purpose: To compare the risk of secondary cancer from scattered and leakage doses following intensity-modulated radiotherapy (IMRT), volumetric arc therapy (VMAT) and tomotherapy (TOMO) in patients with lung cancer. METHODS: IMRT, VMAT and TOMO were planned for five lung cancer patients. Organ equivalent doses (OEDs) are estimated from the measured ...
Qiu Guanyinsheng - - 2013
As valuable C1 building blocks, isocyanides represent an important class of reactive species and synthons. During the past decades, exhaustive efforts have been devoted to the discovery of highly efficient reactions involving isocyanide on the basis of the development of the Passerini and Ugi reactions. Several types of reactions involving ...
Imo Miriam - - 2013
The epidemiology of vector transmitted plant diseases is highly influenced by dispersal and the host-plant range of the vector. Widening the vector's host range may increase transmission potential, whereas specialization may induce specific disease cycles. The process leading to a vector's host shift and its epidemiological outcome is therefore embedded ...
van den Brom Charissa E - - 2013
Volatile anaesthetics exert protective effects on the heart against perioperative ischaemic injury. However, there is growing evidence that these cardioprotective properties are reduced in case of type 2 diabetes mellitus. A strong predictor of postoperative cardiac function is myocardial substrate metabolism. In the type 2 diabetic heart, substrate metabolism is ...
Frennesson Christina I - - 2013
Purpose:  To analyse a 3-year clinical patient cohort of ranibizumab treatment of exudative age-related macular degeneration (AMD), to investigate the impact on visual outcome of carrying forward the last acuity observation in drop-outs and to explore possible differences between the early and the late phase of the study. Methods:  A ...
González-Pérez Gabriela - - 2013
The peripheral repertoire of CD4+ T lymphocytes contains autoreactive cells that remain tolerant through several mechanisms. However, nonspecific CD4+ T cells can be activated in physiological conditions as in the course of an ongoing immune response, and their outcome is not yet fully understood. Here, we investigate the fate of ...
Mohan Murugabalaji K - - 2013
To determine whether implementation of the Cerner FirstNet electronic medical record system was associated with any change in emergency department (ED) performance. A retrospective observational study conducted during a 6-03 period in 2009 after the introduction of FirstNet and a corresponding 6-03 control period in 2008 when the Emergency Department Information System ...
Palikhe Muna - - 2013
Abstract Objective. The objective of this study is to analyze the changes in portal hemodynamics that occurs in portal hypertension before and after transjugular intrahepatic portosystemic shunt (TIPS), to investigate the relationship between these changes and portal pressure (PP) and to determine the significance of sonographic parameters in measuring PP. ...
Akerley Wallace L - - 2013
Abstract Objective. To assess the impact of a serum-based proteomic test for non-small cell lung cancer (NSCLC) on physician treatment recommendations. Research design and methods. A multivariate, serum-based proteomic test (VeriStrat 1 ) is commercially available to assist physicians when determining treatment using epidermal growth factor receptor inhibitor (EGFRi) therapy, ...
Dewitt J - - 2013
Neuroblastoma arises from sympathoadrenal progenitors of the neural crest and expression of the neurotrophin receptor TrkB and its ligand, brain-derived neurotrophic factor (BDNF), is correlated with poor prognosis. Although activated TrkB signaling promotes a more aggressive phenotype in established neuroblastoma cell lines, whether TrkB signaling is sufficient to transform neural ...
Chaudhary A - - 2013
Nematodes of the family Thelastomatidae are parasitic in the alimentary tract of many arthropods, including Periplaneta americana L. In Meerut, Uttar Pradesh, India, two nematode species, namely Hammerschmidtiella indicus and Thelastoma icemi, belonging to this family have been reported. In the present study, the molecular phylogeny of these two nematode ...
Lee Qim Yi - - 2013
Background Cardiac output (CO) and systemic vascular resistance (SVR) are two important parameters of the cardiovascular system. The ability to measure these parameters continuously and noninvasively may assist in diagnosing and monitoring patients with suspected cardiovascular diseases, or other critical illnesses. In this study, a method is proposed to estimate ...
Asari Reza - - 2013
Dear Editor, with interest we read the article by Bajpai et al. (1), entitled Prolonged exposure to acid and bile induces chromosome abnormalities that precede malignant transformation of benign Barrett's epithelium", which has been published in the recent issue of Molecular Cytogenetics. Barrett's esophagus results from gastroesophageal reflux and harbors ...
Sharma Anupma - - 2013
BACKGROUND: Tandem repeats are ubiquitous and abundant in higher eukaryotic genomes and constitute, along with transposable elements, much of DNA underlying centromeres and other heterochromatic domains. In maize, centromeric satellite repeat (CentC) and centromeric retrotransposons (CR), a class of Ty3/gypsy retrotransposons, are enriched at centromeres. Some satellite repeats have homology ...
Nunes Maria D S - - 2013
Strict maternal inheritance is considered a hallmark of animal mtDNA. Although recent reports suggest that paternal leakage occurs in a broad range of species, it is still considered an exceptionally rare event. To evaluate the impact of paternal leakage on the evolution of mtDNA, it is essential to reliably estimate ...
Moore Laurence - - 2013
OBJECTIVE: An increasing focus on legislation, policy and guidance on the nutritional content of school food has in part been in response to the limited impact of more behavioural or educational approaches. However, there is a risk that a sole focus on policy-level action may lead to neglect of the ...
Mok N Yi - - 2013
The efficiency of automated compound screening is heavily influenced by the design and the quality of the screening libraries used. We recently reported on the assembly of one diverse and one target-focused lead-like screening library. Using data from 15 enzyme-based screenings conducted using these libraries, their performance was investigated. Both ...
Deagle Bruce E - - 2013
Threespine stickleback populations are model systems for studying adaptive evolution and the underlying genetics. In lakes on the Haida Gwaii archipelago (off western Canada), stickleback have undergone a remarkable local radiation and show phenotypic diversity matching that seen throughout the species distribution. To provide a historical context for this radiation, ...
Vincent Jean-Louis - - 2013
Over the last two decades, many of the mechanisms underlying the pathophysiology of sepsis have been uncovered, but this has not led to the development of effective therapies for sepsis. Despite improvements in the general care of critically ill patients in recent years, mortality rates for patients with severe sepsis ...
Giannini Edoardo G - - 2013
Thrombocytopenia may represent a barrier to optimal management of chronic liver disease patients undergoing invasive procedures, or who need to be treated with interferon-based antiviral therapy. Eltrombopag is a thrombopoietic drug that acts upon binding thrombopoietin receptor and stimulates megakaryocytopoiesis and platelet production. A summary of the preclinical studies and ...
Verheyen Nicolas - - 2013
Effective therapeutic strategies are warranted to reduce the burden of parathyroid hormone excess related morbidity and mortality. The calcimimetic agent cinacalcet hydrochloride is a promising treatment strategy in hyperparathyroidism. This review provides an overview of the pharmacokinetics, clinical efficacy, cost-effectiveness, safety and the efficacy profile of cinacalcet in the setting ...
Giarenis Ilias I Department of Urogynaecology, King's College Hospital, London, UK. - - 2013
What's known on the subject? and what does the study add?: Overactive bladder syndrome (OAB) is a highly prevalent medical condition, which is linked to the urodynamic observation of detrusor overactivity (DO). Urodynamics detect DO in about half of female patients with OAB. Our study detects significant differences between female ...
Ling L S - - 2013
The phosphatidylinositol 3' kinase (PI3K) pathway is involved in many cellular processes including cell proliferation, survival and glucose transport, and is implicated in various disease states, such as cancer and diabetes. Although there have been numerous studies dissecting the role of PI3K signaling in different cell types and disease models, ...
Rintoul Angela C AC Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia. - - 2013
To examine the rate of detection of alprazolam among cases of heroin-related death (HRD) in Victoria, including the relationship between alprazolam supply and HRDs. Population-based study of community alprazolam supply in Victoria and HRDs reported to the Victorian coroner from January 1990 to December 2010. Number of prescriptions for alprazolam ...
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