Search Results
Results 251 - 300 of 5166
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Kim Kwang Hyun - - 2013
OBJECTIVE: To more clearly elucidate the association between prostate volume and Gleason score (GS) upgrading. PATIENT AND METHODS: We reviewed 451 patients with prostate cancer with a GS of 6 on biopsy, who underwent radical prostatectomy without neoadjuvant treatment. As a preoperative variable, we assessed the independent effect of prostate ...
Whitfield Clare - - 2013
AIMS AND OBJECTIVES: To identify sources of information and support preferred by young people to understand adolescent practices as adolescents develop a sexual health knowledge base. BACKGROUND: Statistics suggest that adolescents are not always making safe sexual health decisions. It is essential to develop an understanding of preferred sources of ...
Wang Zhong-Ming - - 2013
Zebrias zebrinus belongs in the family Soleidae of Pleuronectiformes. There are overlaps in the ranges of identification characters between Z. zebrinus and another striped sole Z. fasciatus. In this study, the complete mitochondrial genome of Z. zebrinus was first determined. The total length was 16,758 bp, including 13 protein-coding genes, 22 ...
Flydal Marte I - - 2013
Mammalian phenylalanine hydroxylase (PAH) catalyzes the rate-limiting step in the phenylalanine catabolism, consuming about 75% of the phenylalanine input from the diet and protein catabolism under physiological conditions. In humans, mutations in the PAH gene lead to phenylketonuria (PKU), and most mutations are mainly associated with PAH misfolding and instability. ...
Schmidt Carla - - 2013
Simple protein separation by one dimensional (1D) gel electrophoresis is a widely used method to reduce sample complexity and to prepare proteins for mass spectrometric identification via in-gel digestion. While several automated solutions are available for in-gel digestion particularly of small cylindric gel plugs derived from 2D gels, the processing ...
Gonzalez-Flores A - - 2013
Hypoxia-inducible factors (HIFs) mediate the transcriptional adaptation of hypoxic cells. The extensive transcriptional programm regulated by HIFs involves the induction of genes controlling angiogenesis, cellular metabolism, cell growth, metastasis, apoptosis, extracellular matrix remodeling and others. HIF is a heterodimer of HIF-α and HIF-β subunits. In addition to HIF-1α, HIF-2α has ...
Kowalczyk Keith J - - 2013
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Retrospective data have suggested an increased survival benefit for patients undergoing partial nephrectomy compared to radical nephrectomy, possibly as a result of the avoidance of long-term renalin sufficiency and subsequent sequelae. However, recent level-one evidence has questioned this benefit. ...
Scappucci Giordano - - 2013
We review our recent research into n-type doping of Ge for nanoelectronics and integrated photonics. We demonstrate a doping method in ultra-high vacuum to achieve high electron concentrations in Ge while maintaining atomic-level control of the doping process. We integrated this doping technique with ultra-high vacuum scanning tunneling microscope lithography ...
Frost Charles - - 2013
AIMS: Apixaban is an oral factor Xa inhibitor approved for stroke prevention in atrial fibrillation and thromboprophylaxis in patients who have undergone elective hip or knee surgery and under development for treatment of venous thrombosis. This study examined the safety, pharmacokinetics and pharmacodynamics of multiple-dose apixaban. METHODS: This double-blind, randomized, ...
Root James C - - 2013
OBJECTIVE: Post-operative delirium is associated with pre-operative cognitive difficulties and diminished functional independence, both of which suggest that brain pathology may be present in affected individuals prior to surgery. Currently, there are few studies that have examined imaging correlates of post-operative delirium. To our knowledge, none have examined the association ...
Shinaoka Akira - - 2013
Most blood vessels contain elastin that provides the vessels with the resilience and flexibility necessary to control hemodynamics. Pathophysiological hemodynamic changes affect the remodeling of elastic components, but little is known about their structural properties. The present study was designed to elucidate, in detail, the three-dimensional (3D) architecture of delicate ...
Chiu Ming-Hung - - 2013
We propose a nonscanning three-dimensional (3D) optical microscope based on reflectivity-height transformation in applications of biological and transparent plate measurements. The reflectivity of a prism can be transformed to the surface height of the specimen based on geometrical optics and the principle of internal reflection. Thus, the pattern of reflectivity ...
Punnen Sanoj - - 2013
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Previous studies have shown that robot-assisted radical prostatectomy (RARP) can be performed in men with high-risk prostate cancer with similar outcomes to that of open surgery. However, most of the literature consists of small case series and compares RARP ...
Ferrante Marc - - 2013
Introduction: The introduction of antibodies directed against tumour necrosis factor (anti-TNF) has dramatically changed the concept of treating patients with Crohn's disease (CD). Unfortunately, the long-term efficacy of anti-TNF agents may be hampered by immunogenicity. The availability of more anti-TNF agents in the therapeutic armamentarium would therefore be of great ...
Raadsma H W - - 2013
The pursuits of white features and white fleeces free of pigmented fibre have been important selection objectives for many sheep breeds. The cause and inheritance of non-white colour patterns in sheep has been studied since the early 19th century. Discovery of genetic causes, especially those which predispose pigmentation in white ...
Keller Daniela - - 2013
Most landscape genetic studies assess the impact of landscape elements on species' dispersal and gene flow. Many of these studies perform their analysis on all possible population pairs in a study area and do not explicitly consider the effects of spatial scale and population network topology on their results. Here, ...
Schulz Stefanie - - 2013
Aims: Thirty-day results of the double-blind, randomised Intracoronary Stenting And Antithrombotic Regimen -Rapid Early Action for Coronary Treatment (ISAR-REACT) 4 trial showed no difference in ischaemic complications and a reduction in bleeding by bivalirudin versus abciximab and heparin in 1,721 patients with non-ST-segment elevation myocardial infarction (NSTEMI) undergoing percutaneous coronary ...
Wang Baogang - - 2013
Versatile efforts have been made to improve the stability of graphite/ethylene glycol (EG) nanofluids. Primitively, non-dispersible graphite nanoparticles were converted to graphite oxide nanoparticles (GONs) by acid treatment. Although GONs could be well dispersed in EG, the GONs/EG nanofluids exhibited limited stability up to less than 1 day. And then, ...
Tillfors Maria - - 2013
Previous research has identified a subgroup of socially anxious adults who are both anxious and impulsive. To date, however, this subgroup has not been identified in adolescence. Therefore, in this study we aimed to identify this subgroup in a sample of adolescents. In addition, we hypothesized that this subgroup would ...
Won Ki-Bum - - 2013
BACKGROUND: Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis (SCA) according to diabetes status are scarce. METHODS: Surrogate markers of SCA, brachial--ankle pulse wave velocity (baPWV), and carotid intima--medial thickness ...
Amatore Muriel - - 2013
A new asymmetric [2+2+2] cycloaddition of diynes to sulfonimines under rhodium catalysis is described, providing the corresponding enantioenriched 1,2-dihydropyridines in good yields.
Flourié B - - 2013
BACKGROUND: Aminosalicylates are first-choice treatment for mild-to-moderately active ulcerative colitis (UC); however, multi-dosing regimens are inconvenient. AIM: To compare the efficacy and safety of once- (OD) vs. twice- (BD) daily prolonged-release mesalazine (Pentasa, Ferring, Saint-Prex, Switzerland) for active mild-to-moderate UC in a non-inferiority study. METHODS: Eligible patients (n = 206) were randomised ...
Aronsson Carin Andrén - - 2013
OBJECTIVES: The aim of the present study was to examine the prevalence and associated factors of dietary supplement use, particularly supplements containing vitamin D and fatty acids, in pregnant women enrolled in a multi-national study. DESIGN: The Environmental Determinants of Diabetes in the Young (TEDDY) study is a prospective longitudinal ...
Zuo Rantao - - 2013
The effects of conjugated linoleic acid (CLA) on growth performance, non-specific immunity, antioxidant capacity, lipid deposition and related gene expression were investigated in the large yellow croaker (Larmichthys crocea). Fish (7·56 (sem 0·60) g) were fed soyabean oil-based diets with graded levels of CLA (0, 0·42, 0·83, 1·70 %) for 70 d. Quantitative ...
Legacy Jacqueline - - 2013
Lack of regeneration in the adult central nervous system (CNS) is a major hurdle that limits recovery from neurological ailments. Although accumulating research suggests the possibility of axon regeneration by targeting intrinsic signaling mechanisms, it remains a matter of controversy whether functional recovery can be achieved by manipulating aspects of ...
Woodruff Sarah J - - 2013
OBJECTIVE: The purpose was to examine the associations among body weight status, blood pressure and daily Na intake among grade 7 students from south-western Ontario, Canada. DESIGN: Cross-sectional. Data were collected using the Food Behaviour Questionnaire, including a 24 h diet recall. Measured height and weight were used to determine ...
Halsey Kimberly H - - 2013
We compare the nutrient-dependent photosynthetic efficiencies of the chlorophyte, Dunaliella tertiolecta, with those of the marine diatom, Thalassiosira weissflogii. Despite considerable evolutionary and physiological differences, these two species appear to use nearly identical growth strategies under a wide range of nutrient limitation. Using a variety of physiological measurements, we find ...
Huang Jiwei - - 2013
OBJECTIVE: To evaluate whether remote ischaemic preconditioning (RIPC) reduces renal injury in patients undergoing laparoscopic partial nephrectomy (LPN). PATIENTS AND METHODS: In all, 82 patients undergoing LPN were randomly assigned to either the RIPC or control group, with 40 and 38 patients, respectively completing 6-months follow-up. RIPC was conducted after ...
Modery-Pawlowski Christa Lynn - - 2013
Whole blood or RBC transfusions are highly significant, clinically, for blood replacement therapies in traumatic injuries, pre-surgical conditions and anemias. However, natural RBC-based products suffer from limited shelf-life due to pathological contamination, and also present risks of refractoriness, graft-versus-host disease, immunosuppression and acute lung injury. These issues can be only ...
Huang Jingfeng - - 2013
We report the extended growth of Graphene Oxide (GO) flakes using atmospheric pressure ethanol Chemical Vapor Deposition (CVD). GO was used to catalyze the deposition of carbon on a substrate in the ethanol CVD with Ar and H2 as carrier gases. Raman, SEM, XPS and AFM characterized the growth to ...
Martinelli A - - 2013
We report on how the local structure and the diffusional motion change upon increasing the alkyl chain length in 1-alkyl-3-methylimidazolium cation ionic liquids. This study has been performed by combining pulse field gradient (PFG) nuclear magnetic resonance (NMR) spectroscopy and small angle X-ray scattering (SAXS) experiments. The cationic side chain ...
Kelly M J - - 2013
BACKGROUND: Most consultants participating as referees in the peer review process of articles submitted to scholary journals have had no training or tuition. This study attempted to evaluate the effect on reviewing of a half-day course held at the Royal Society of Medicine (RSM) METHOD: Registered consultant delegates were sent ...
Atwa M A - - 2013
BACKGROUND: Chronic spontaneous urticaria (CSU) is a common skin disorder, which is considered in a subset of patients to be an autoimmune disorder. T helper 17 (Th17) cells are crucially involved in the pathogenesis of some autoimmune diseases. OBJECTIVES: Our aim was to test the association of Th17 with CSU. ...
Liu Xuemei - - 2013
The Naihai cutlassfish (Trichiurus nanhaiensis, Wang and Xu, 1992) is an important commercial fish species in South China Sea, while the taxonomy is still controversial. The 17,060 base pair mitochondrial genome sequence of T. nanhaiensis was determined, which shared the features with the other bony fishes for gene arrangement, nucleotide ...
Rahkola-Soisalo Päivi - - 2013
OBJECTIVE: Both smoking and the release of nitric oxide (NO) in the uterine cervix are determinants for high-risk human papillomavirus (hrHPV) infection. We compared the cervical NO release between smoking and non-smoking women with and without hrHPV infection. DESIGN: Open clinical cohort study. SETTING: University Hospital in Finland. POPULATION: One ...
Luca Alessio Di - - 2013
Variation in water holding capacity (WHC), which presents a major economic burden to the swine industry, is considered to be underpinned by variation at a molecular and biochemical level. High resolution 2-D DIGE followed by MS analysis and Western blot were used to unravel the proteome of muscle exudate, collected ...
Wang Peng - - 2013
A highly stable p-type cuprous oxide (Cu2O) photoelectrode has been fabricated by direct anodization of the Cu foil, followed by a thermal treatment to introduce a protective layer of copper oxide (CuO) nanowires penetrating the surface of the Cu2O layer. The anodized Cu2O served as the seeding sites for the ...
Wong Vincent W - - 2013
In this retrospective study, pregnant women with type 1 diabetes under the care of diabetes specialists pre-conception were found to have better glycaemic control and pregnancy outcomes than those not under specialist care prior to pregnancy. These differences were not seen in women with type 2 diabetes. The study showed ...
Matsoukas Ianis G - - 2013
The physiology and genetics underlying juvenility is poorly understood. Here we exploit Arabidopsis as a system to understand the mechanisms that regulate floral incompetence during juvenility. Using an experimental assay that allows the length of juvenility to be estimated, and mutants impaired in different pathways, we show that multiple inputs ...
Sutariya Pinkesh G - - 2013
A novel PET (photoinduced electron transfer) based substituted calix[4]arene fluoroionophore has been synthesized and used for the selective recognition of Cd2+ and Sr2+ by emission spectra. The detection limit of the synthesized receptor was found to be 0.94 pM for Cd2+ and 1.04 pM for Sr2+. Moreover, this probe has ...
Yap Desmond Yat Hin - - 2013
The pathogenesis of systemic lupus erythematosus (SLE) entails a complex interaction between the different arms of the immune system. While autoantibodies production and immune complex deposition are cornered as hallmark features of SLE, there is growing evidence to propose the pathogenic role of cytokines in this disease. Examples of these ...
Marqués N - - 2013
Prostate tumor overexpressed-1 (PTOV1), a modulator of the Mediator transcriptional regulatory complex, is expressed at high levels in prostate cancer and other neoplasias in association with a more aggressive disease. Here we show that PTOV1 interacts directly with receptor of activated protein C kinase 1 (RACK1), a regulator of protein ...
Tsai An-Pang - - 2013
The geometrical concept and structural framework of quasicrystals (QCs) were established shortly after the discovery of QCs. Specifically, the static and dynamic properties of the atoms and the electronic structures of quasiperiodic lattices were theoretically developed. Experimental studies lagged behind theoretical progress due to the lack of suitable samples. This ...
Mehraeen Shareghe - - 2013
The advent of aberration correction for transmission electron microscopy has transformed atomic resolution imaging into a nearly routine technique for structural analysis. Now an emerging frontier in electron microscopy is the development of in situ capabilities to observe reactions at atomic resolution in real time and within realistic environments. Here ...
Sreenivasan Varun K A - - 2013
High-affinity molecular pairs provide a convenient and flexible modular base for the design of molecular probes and protein/antigen assays. Specificity and sensitivity performance indicators of a bioassay critically depend on the dissociation constant (KD ) of the molecular pair, with avidin:biotin being the state-of-the-art molecular pair (KD ∼ 1 fM) ...
Farhi A - - 2013
Objective: To evaluate the risk for congenital malformations diagnosed at birth following Assisted Reproductive Technology (ART) treatments compared with live births conceived spontaneously. Methods: A retrospective cohort study including 9,042 live births following ART and 213,288 spontaneously conceived live births during the period 1997-2004. The cohort was linked to the ...
Jdid R - - 2013
BACKGROUND: Sleep lines are caused by individual's sleeping positions and should be differentiated from expression wrinkles. OBJECTIVE: The aim of the study was to investigate possible risk factors for sleep lines on a sizeable sample of middle-aged Caucasian women. METHODS: This study involved a sample of 542 French middle-aged women ...
White Christopher R H - - 2013
BACKGROUND: Despite a growing body of evidence demonstrating the value of universal umbilical cord blood gas analysis (UCBGA), there remains reluctance in some maternity units to adopt universal testing. AIMS: Identify perceived barriers and benefits of universal UCBGA. METHODS: Medical and midwifery staff involved in intrapartum care at four level ...
Nadolna K - - 2013
In the present investigation a sample of 490 cod (Gadus morhua) was examined from three regions in the southern Baltic Sea (the Polish Exclusive Economic Zone, EEZ). Three species of anisakid nematodes with zoonotic potential, namely species of Contracaecum, Anisakis and Pseudoterranova, were found in the liver of cod, with ...
Ma Jingjing - - 2013
AIM: Animal and in vitro studies suggest that the use of bisphosphonates (BP) may be associated with reduced risk for colorectal cancer (CRC). However, results from these studies have been inconsistent. The aim of our study was to review and summarize the evidence provided by longitudinal studies on the association ...
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