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Results 251 - 300 of 5189
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Alvarez Meihwa Tanielle Bench - - 2013
Analysis of the protein/peptide composition of tissue has provided meaningful insights into tissue biology and even disease mechanisms. However, little has been published regarding top down methods to investigate lower molecular weight (MW) (500-5000 Da) species in tissue. Here we evaluate a tissue proteomics approach involving tissue homogenization followed by ...
Wu Shengli - - 2013
OBJECTIVE: To identify the optimal threshold of HbA1c and to evaluate the predictive performance of HbA1c levels in diagnosing diabetes and prediabetes in a middle-aged and elderly Han Chinese population from northwest China. METHODS: A total of 3354 participants aged 40 years or older with no history of diabetes from ...
Hayasaka Daisuke - - 2013
BACKGROUND: Tick-borne encephalitis virus (TBEV) is a causative agent of acute central nervous system disease in humans. It has three subtypes, far eastern (FE), Siberian (Sib) and European (Eu) subtypes, which are distributed over a wide area of Europe and Asia. The objective of this study was to develop a ...
Kong Junhua - - 2013
Silicon (Si) is a promising material for lithium ion battery (LIB) anodes due to its high specific capacity. To overcome its shortcomings such as insulation property and large volume change during the charge-discharge process, a novel hybrid system, Si nanoparticles encapsulated in hollow graphitized carbon nanofibers, is studied. First, electrospun ...
Brunn Anna - - 2013
AIM: The role of chemokines and their receptors, which regulate trafficking and homing of leukocytes to inflamed organs in human or murine autoimmune neuritis has not yet been elucidated in detail, Therefore, the role of the chemokine receptors CXCR4 and CXCR7 and their ligand CXCL12 was studied in autoimmune-mediated inflammation ...
Becker T M - - 2013
Approximately 50% of melanomas depend on mutant B-RAF for proliferation, metastasis and survival. The inhibition of oncogenic B-RAF with highly targeted compounds has produced remarkable albeit short-lived clinical responses in B-RAF mutant melanoma patients. Reactivation of signaling downstream of B-RAF is frequently associated with acquired resistance to B-RAF inhibitors, and ...
Johnson Jennifer E - - 2013
The distribution of nitrogen isotopes in the biosphere has the potential to offer insights into the past, present, and future of the nitrogen cycle, but it is challenging to unravel the processes controlling patterns of mixing and fractionation. We present a mathematical model describing a previously overlooked process: nitrogen isotope ...
Vincent Jean-Louis - - 2013
Over the last two decades, many of the mechanisms underlying the pathophysiology of sepsis have been uncovered, but this has not led to the development of effective therapies for sepsis. Despite improvements in the general care of critically ill patients in recent years, mortality rates for patients with severe sepsis ...
Jia Chun-Lin - - 2013
A single layer of LaAlO3 with a nominal thickness of one unit cell, which is sandwiched between a SrTiO3 substrate and a SrTiO3 capping layer, is quantitatively investigated by high-resolution transmission electron microscopy. By the use of an aberration-corrected electron microscope and by employing sophisticated numerical image simulation procedures, significant ...
Gao Huile - - 2013
Aim: The poor water solubility of many active compounds is a serious deterrent to their use as commercial drugs. Lapatinib is a dual inhibitor of the EGF receptor and EGF receptor 2 approved by the US FDA to treat advanced breast cancer. This study prepares lapatinib-incorporated lipoprotein-like nanoparticles (LTNPs) to ...
Qun Z - - 2013
Supplementation of branched-chain amino acid (BCAA) is often used to attenuate exercise-induced skeletal muscle damage and promote adaptation, but no definitive conclusion on the benefits of BCAA on muscle recovery after injurious exercise can be drawn. Exploration of the systematic BCAA alteration in muscular injury-repair stage per se without any ...
Iturrino J - - 2013
BACKGROUND: Daikenchuto, a Japanese herbal medicine used for post-operative ileus and constipation, dose dependently stimulates gastrointestinal (GI) motility and decreases rectal compliance and sensation. Effects of TU-100 (commercial form of daikenchuto) in adults with constipation are unknown. AIM: To compare the effects of oral TU-100, 2.5 g t.d.s. or 5 g t.d.s. ...
Sandaite Inga - - 2013
OBJECTIVE: To report on the feasibility of assessing cardiac structures on post-mortem 3-tesla MRI (pmMRI) and to provide morphometric data in fetuses without cardiac abnormalities. METHODS: Retrospective single center study on 3T pmMRI of 39 consecutive fetuses without cardiac abnormalities (13-38 weeks of gestation). Fetal cardiac anatomy was assessed and measurements ...
Heeley Ellen L - - 2013
Polyhedral oligomeric silsesquioxane (POSS) cubic cage systems (octa-n-octadecyloctasilsesquioxane, (T8C18) and octakis(n-octadecyldimethylsiloxy)octasilsesquioxane, (Q8C18)) were synthesised with eight long n-alkyl chain (R = C18H37) substituent arms, as model nano-functionalized compounds. The crystalline packing morphology of the cages was studied using time-resolved Small- and Wide-angle X-ray scattering (SAXS/WAXS), thermal and optical techniques. From ...
Verdier Jerome J Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, - - 2013
Lotus japonicus is a model species for legume genomics. To accelerate legume functional genomics, we developed a Lotus japonicus Gene Expression Atlas (LjGEA), which provides a global view of gene expression in all organ systems of this species, including roots, nodules, stems, petioles, leaves, flowers, pods and seeds. Time-series data ...
Cornforth Daniel M - - 2013
The field of ecology has long recognized two types of competition: exploitative competition, which occurs indirectly through resource consumption, and interference competition, whereby one individual directly harms another. Here, we argue that these two forms of competition have played a dominant role in the evolution of bacterial regulatory networks. In ...
Willett Mark - - 2013
During cell spreading, mammalian cells migrate using lamellipodia formed from large dense branched actin network which produce the protrusive force required for leading edge advancement. The formation of lamellipodia is a dynamic process and dependent on a variety of protein co-factors that mediate their local regulation, structural characteristics and dynamics. ...
Olafsdottir Eydis - - 2013
Purpose:  To evaluate the prevalence of and risk factors for, retinopathy in a geographically defined population with type 2 diabetes mellitus compared with a control group of subjects without diabetes, matched by age, sex and residence in order to find the retinopathy attributable to type 2 diabetes. Methods:  The study ...
Scappucci Giordano - - 2013
We review our recent research into n-type doping of Ge for nanoelectronics and integrated photonics. We demonstrate a doping method in ultra-high vacuum to achieve high electron concentrations in Ge while maintaining atomic-level control of the doping process. We integrated this doping technique with ultra-high vacuum scanning tunneling microscope lithography ...
Root James C - - 2013
OBJECTIVE: Post-operative delirium is associated with pre-operative cognitive difficulties and diminished functional independence, both of which suggest that brain pathology may be present in affected individuals prior to surgery. Currently, there are few studies that have examined imaging correlates of post-operative delirium. To our knowledge, none have examined the association ...
Shinaoka Akira - - 2013
Most blood vessels contain elastin that provides the vessels with the resilience and flexibility necessary to control hemodynamics. Pathophysiological hemodynamic changes affect the remodeling of elastic components, but little is known about their structural properties. The present study was designed to elucidate, in detail, the three-dimensional (3D) architecture of delicate ...
Chiu Ming-Hung - - 2013
We propose a nonscanning three-dimensional (3D) optical microscope based on reflectivity-height transformation in applications of biological and transparent plate measurements. The reflectivity of a prism can be transformed to the surface height of the specimen based on geometrical optics and the principle of internal reflection. Thus, the pattern of reflectivity ...
Rahkola-Soisalo Päivi - - 2013
OBJECTIVE: Both smoking and the release of nitric oxide (NO) in the uterine cervix are determinants for high-risk human papillomavirus (hrHPV) infection. We compared the cervical NO release between smoking and non-smoking women with and without hrHPV infection. DESIGN: Open clinical cohort study. SETTING: University Hospital in Finland. POPULATION: One ...
Luca Alessio Di - - 2013
Variation in water holding capacity (WHC), which presents a major economic burden to the swine industry, is considered to be underpinned by variation at a molecular and biochemical level. High resolution 2-D DIGE followed by MS analysis and Western blot were used to unravel the proteome of muscle exudate, collected ...
Wang Peng - - 2013
A highly stable p-type cuprous oxide (Cu2O) photoelectrode has been fabricated by direct anodization of the Cu foil, followed by a thermal treatment to introduce a protective layer of copper oxide (CuO) nanowires penetrating the surface of the Cu2O layer. The anodized Cu2O served as the seeding sites for the ...
Ishiko Toshihiro - - 2013
Keloids are a proliferative fibrotic disease characterized by abnormal accumulation of extracellular matrix in the dermis. Keloid lesions lack skin plasticity due to deficiencies in elastic fiber formation in the extracellular matrix. The loss of elastic fiber is caused by excessive accumulation of chondroitin sulfate (CS), a sulfated glycosaminoglycan. However, ...
Giles Michelle L - - 2013
BACKGROUND: Mother-to-child transmission (MTCT) of hepatitis B virus continues to occur despite the interventions of hepatitis B vaccination and immunoglobulin. The most significant risk factor in transmission is high maternal viral load. Being aware of viral replicative activity permits risk stratification and allows the opportunity for additional preventative measures such ...
Rahnama'i Mohammad S - - 2013
OBJECTIVE: To study PDE5 localisation by visualising the product of phosphodiesterase type 5 (PDE5) inhibition, namely cGMP, to determine the site of action of inhibitors in the urinary bladder. MATERIALS AND METHODS: Bladders of nine male guinea pigs were dissected and treated in wells containing 2 mL Krebs' solution and 1 μM ...
Kim B I - - 2013
The direct and interactive effects of climate change on host species and infectious disease dynamics are likely to initially manifest\ at latitudinal extremes. As such, Alaska represents a region in the United States for introspection on climate change and disease. Rabies is enzootic among arctic foxes (Vulpes lagopus) throughout the ...
Wan Dehui - - 2013
A facile, robust approach to the synthesis of Au cubic nanoframes is described. The synthesis involves three major steps: 1) preparation of Au-Ag alloyed nanocages using a galvanic replacement reaction between Ag nanocubes and HAuCl4 ; 2) deposition of thin layers of pure Au onto the surfaces of the nanocages ...
Wang Yan - - 2013
The electrochemical dealloying of rapidly solidified Al2(Au,X) (X = Pt, Pd, PtPd, Ni, Co and NiCo) precursors in a 1.0 M NaCl aqueous solution has been systematically investigated using electrochemical measurements including open-circuit measurement, potentiodynamic polarization and potentiostatic polarization, and microstructural analysis. The results show that the kind of alloying ...
Pham Ngoc Minh - - 2013
OBJECTIVE: To examine the association between the consumption of green tea, coffee and caffeine and depressive symptoms. DESIGN: Cross-sectional study. Consumption of green tea and coffee was ascertained with a validated dietary questionnaire and the amount of caffeine intake was estimated from these beverages. Depressive symptoms were measured using the ...
Langenbucher Achim - - 2013
PURPOSE: To demonstrate a mathematical algorithm for calculating the refractive power of keratoprostheses and to estimate vignetting effects. METHODS: A paraxial calculation scheme based on vergence transformation is developed for determination of the front surface radius or front surface refractive power of a Boston type I or II keratoprosthesis based ...
Mohan Murugabalaji K - - 2013
To determine whether implementation of the Cerner FirstNet electronic medical record system was associated with any change in emergency department (ED) performance. A retrospective observational study conducted during a 6-03 period in 2009 after the introduction of FirstNet and a corresponding 6-03 control period in 2008 when the Emergency Department Information System ...
Palikhe Muna - - 2013
Abstract Objective. The objective of this study is to analyze the changes in portal hemodynamics that occurs in portal hypertension before and after transjugular intrahepatic portosystemic shunt (TIPS), to investigate the relationship between these changes and portal pressure (PP) and to determine the significance of sonographic parameters in measuring PP. ...
Moore Laurence - - 2013
OBJECTIVE: An increasing focus on legislation, policy and guidance on the nutritional content of school food has in part been in response to the limited impact of more behavioural or educational approaches. However, there is a risk that a sole focus on policy-level action may lead to neglect of the ...
Akerley Wallace L - - 2013
Abstract Objective. To assess the impact of a serum-based proteomic test for non-small cell lung cancer (NSCLC) on physician treatment recommendations. Research design and methods. A multivariate, serum-based proteomic test (VeriStrat 1 ) is commercially available to assist physicians when determining treatment using epidermal growth factor receptor inhibitor (EGFRi) therapy, ...
Dewitt J J Department of Anatomy and Neurobiology and Neuroscience Graduate Program, University of Vermont, Burlington, VT, - - 2014
Neuroblastoma arises from sympathoadrenal progenitors of the neural crest and expression of the neurotrophin receptor TrkB and its ligand, brain-derived neurotrophic factor (BDNF), is correlated with poor prognosis. Although activated TrkB signaling promotes a more aggressive phenotype in established neuroblastoma cell lines, whether TrkB signaling is sufficient to transform neural ...
Chaudhary A - - 2013
Nematodes of the family Thelastomatidae are parasitic in the alimentary tract of many arthropods, including Periplaneta americana L. In Meerut, Uttar Pradesh, India, two nematode species, namely Hammerschmidtiella indicus and Thelastoma icemi, belonging to this family have been reported. In the present study, the molecular phylogeny of these two nematode ...
Rauschhuber Christina - - 2013
RNA interference (RNAi) is a key regulator of various biological systems including viral infection. Within a virus life cycle gene products can be modulated by the RNA interference (RNAi) pathway which can crucially impact productive virus replication. Herein we explored the RNA interference suppressor protein P19 derived from a plant ...
Arduino P G - - 2013
BACKGROUND: Oral lichen planus (OLP) is a chronic inflammatory disease, affecting nearly 1-2% of the population; Proposed therapies are usually symptomatic and numerous drugs have been used, but recently, it has been published that there is insufficient evidence to support the effectiveness of any specific treatment as being superior. To ...
Chan Pick Kuen - - 2013
Three independent ethylene insensitive mutants were selected from an EMS- mutagenized population of Lotus japonicus MG-20 (Miyakojima). The mutants, called 'Enigma', were mutated in the LjEIN2a gene from Lotus chromosome 1, sharing significant homology with Arabidopsis EIN2 (ethylene-insensitive2). All three alleles showed classical ethylene insensitivity phenotypes (e.g., Triple Response), but ...
Kavitha Thangavelu - - 2013
Graphene oxide (GO) was functionalized covalently with pH-sensitive poly(2-(diethylamino) ethyl methacrylate) (PDEA) by surface-initiated in situ atom transfer radical polymerization. The structure of the PDEA-grafted GO (GO-PDEA) were examined by Fourier-transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis and atomic force microscopy. The grafted PDEA ...
Kang Lei - - 2013
With the rapid developments of the all-solid-state deep-ultraviolet (deep-UV) lasers, the good nonlinear optical (NLO) crystal applied in this spectral region is currently lacking. Here, we design two novel NLO carbonates KBeCOF and RbAlCOF from the first-principles theory implemented in the molecular engineering expert system especially for NLO crystals. Both ...
Couët Nicolas - - 2013
BACKGROUND: We have no clear overview of the extent to which health-care providers involve patients in the decision-making process during consultations. The Observing Patient Involvement in Decision Making instrument (OPTION) was designed to assess this. OBJECTIVE: To systematically review studies that used the OPTION instrument to observe the extent to ...
Ben-Sasi K K Department of Paediatric Pathology, Great Ormond Street Hospital, London, - - 2013
Perinatal autopsy provides essential clinical information, including cause of death; yet, autopsy rates have steadily declined because of parental refusal. Technology now enables less invasive alternatives to traditional autopsy and may increase the acceptability of post-mortem examination. This study aimed to examine the relative acceptability among healthcare professionals of a ...
Zhao Lixia - - 2013
We report the surprising chemiluminescence (CL) behavior of fluorescent carbon dots in the presence of a strong alkaline solution, such as NaOH or KOH. The CL intensity was dependent on the concentration of the base and carbon dots in a certain range. A possible CL mechanism was studied by UV-Vis, ...
Giannini Edoardo G - - 2013
Thrombocytopenia may represent a barrier to optimal management of chronic liver disease patients undergoing invasive procedures, or who need to be treated with interferon-based antiviral therapy. Eltrombopag is a thrombopoietic drug that acts upon binding thrombopoietin receptor and stimulates megakaryocytopoiesis and platelet production. A summary of the preclinical studies and ...
Horiuchi Hiroshi - - 2013
Abstract Background and study aim. Although focal cancer occasionally coexists with gastric hyperplastic polyps, previous studies have reported that white light endoscopy (WLE) and biopsy sampling cannot effectively predict the coexistence of cancer. The aim of this study was to elucidate efficacious predictors for cancer coexistence. Patients and methods. This ...
Arnold Polly L - - 2013
The heterobimetallic complexes [{UO2Ln(py)2(L)}2], combining a singly reduced uranyl cation and a rare-earth trication in a binucleating polypyrrole Schiff-base macrocycle (Pacman) and bridged through a uranyl oxo-group, have been prepared for Ln = Sc, Y, Ce, Sm, Eu, Gd, Dy, Er, Yb, and Lu. These compounds are formed by the ...
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