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Results 201 - 250 of 5189
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Mizerska-Dudka Magdalena - - 2013
The influence of infection with an entomopathogenic strain of Pseudomonas aeruginosa on Galleria mellonella hemocytes was investigated. Extensive bacteriaemia developed 18 h after infection. This was correlated with significant changes in morphology, viability and the spreading ability of immunocompetent hemocytes, namely granulocytes and plasmatocytes. Since bacteriaemia developed, membrane blebbing, cytoplasm vacuolization, ...
Aravindan Sheeja - - 2013
BACKGROUND: Heterogeneously distributed hypoxic areas are a characteristic property of locally advanced breast cancers (BCa) and generally associated with therapeutic resistance, metastases, and poor patient survival. About 50% of locally advanced BCa, where radiotherapy is less effective are suggested to be due to hypoxic regions. In this study, we investigated ...
Chan Zenobia Cy - - 2013
AIMS AND OBJECTIVES: To explore students' attitude towards problem-based learning, creativity and critical thinking, and the relevance to nursing education and clinical practice. BACKGROUND: Critical thinking and creativity are crucial in nursing education. The teaching approach of problem-based learning can help to reduce the difficulties of nurturing problem-solving skills. However, ...
Rofouie M K - - 2013
Comparative molecular field analysis (CoMFA), comparative molecular field analysis region focusing (CoMFA-RF) for optimizing the region for the final partial least square analysis, and comparative molecular similarity indices analysis (CoMSIA) methods were employed to develop three-dimensional quantitative structure-activity relationship (3D-QSAR) models of 1 H NMR chemical shift of NH proton ...
Yeo Sang Chul - - 2013
We report first-principles calculations of adsorption, dissociation, penetration, and diffusion for the complete nitridation mechanism of nitrogen molecules on a pure Fe surface (bcc, ferrite phase). The mechanism of the definite reaction path was calculated by dividing the process into four steps. We investigated various reaction paths for each step ...
Li Xinlei - - 2013
We have presented a theoretical model to elucidate the formation mechanisms of quantum dots (QDs) on patterned substrates, which introduced the perspective that the preferred formation site of QDs is determined by the nonuniformity of wetting layer thickness caused by surface potential. Two different preferred formation sites, low surface curvature ...
Hua Yawen - - 2013
Equilibrium geometries of AlnTi (n=2-24) clusters were studied using density-functional theory with generalized gradient approximation. The resulting geometries showed that the titanium atom remains on the surface of clusters for n<20, but is endohedrally doped from n=20. This structural transition confirms the previous experiment results obtained by studying their abilities ...
Lu Ying-Bo - - 2013
For the potential applications in spintronics, we examine systematically the electronic properties of group-V elements (X) doped ZnO to investigate the magnetic properties induced by X based on density functional theory calculations. Our results indicates that X atoms doped in the form of a substitutional X atom at an O ...
Nunes Maria D S - - 2013
Strict maternal inheritance is considered a hallmark of animal mtDNA. Although recent reports suggest that paternal leakage occurs in a broad range of species, it is still considered an exceptionally rare event. To evaluate the impact of paternal leakage on the evolution of mtDNA, it is essential to reliably estimate ...
Gao Ya-Dong - - 2013
Objective. To investigate the role and underlying mechanisms of store-operated Ca2+ entry (SOCE) in mediating the promoting effect of transforming growth factor (TGF)-β1 on the proliferation of airway smooth muscle cells (ASMCs). Methods. Rat bronchial smooth muscle cells were cultured as we described previously. The intracellular Ca2+ concentration ([Ca2+]i)of ASMCs ...
Hu Hanqiong - - 2013
Deposition of block copolymer thin films is most often accomplished in a serial process where material is spin coated onto a substrate and subsequently annealed, either thermally or by solvent vapor, to produce a well-ordered morphology. Here we show that under appropriate conditions, well-ordered block copolymer films may be continuously ...
Milek Magdalena - - 2013
A bisoxamate ligand containing three different types of coordination sites was designed and synthesized. The developed synthetic strategy was adopted to prepare a related 1,2-bis(2-hydroxybenzamido)benzene-derived ligand. Nickel(ii) complexes of both the novel ligands were obtained and characterized by X-ray crystallography, NMR, electronic absorption spectroscopy, and theoretical calculations.
Bryan Richard T - - 2013
OBJECTIVES: To compare patient and tumour characteristics at presentation from two large bladder cancer cohorts, with recruitment separated by 15-20 years To identify significant differences in the West Midlands' urothelial cancer of the bladder (UCB) population during this period. PATIENTS AND METHODS: Data were collected prospectively from 1478 patients newly ...
Ceppi P - - 2013
Concepts and experimental models derived from basic research have been successfully applied to the field of molecular oncology, tremendously increasing our knowledge of the nature and the progression of tumors. The process of epithelial-to-mesenchymal transition, the cancer stem cell hypothesis, and their functional association and interdependence represent some of the ...
Conway Aaron - - 2013
AIMS AND OBJECTIVES: To explore issues and challenges associated with nurse-administered procedural sedation and analgesia in the cardiac catheterisation laboratory from the perspectives of senior nurses. BACKGROUND: Nurses play an important part in managing sedation because the prescription is usually given verbally directly from the cardiologist who is performing the ...
Thompson Robert J - - 2013
To address the question of surface oxidation in organic electronics the chemical composition at the surface of single crystalline rubrene is spatially profiled and analyzed using Time of Flight - Secondary Ion Mass Spectroscopy (ToF-SIMS). It is seen that a uniform oxide (C42H28O) covers the surface while there is an ...
Honda Tomohiro - - 2013
(2R,3R,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-3-yl 4-O-(6-deoxy-β-D-glucopyranosyl)-α-D-glucopyranoside (CS-1036) is a potent inhibitor of pancreatic and salivary α-amylase. After oral administration of [14C]CS-1036 to rats, the radioactivity was still detectable up to 7-14 days post-dose in various tissues, and its terminal phase in plasma could be explained neither by the exposure of CS-1036 nor its major ...
Cordero-Herrera Isabel - - 2013
SCOPE: Cocoa and (-)-epicatechin (EC), a main cocoa flavanol, have been suggested to exert beneficial effects in diabetes, but the mechanism for their insulin-like effects remains unknown. In this study, the modulation of insulin signalling by EC and a cocoa phenolic extract (CPE) on hepatic HepG2 cells was investigated by ...
Yasuike Tomokazu - - 2013
The optical responses of metal clusters, M8 (M = Au, Ag and Cu), are investigated by the linear response theory based on the density functional theory. Unlike sodium clusters [Yasuike et al., Phys. Rev. A, 2011, 83, 013201], the plasmonic excitations in the present metal clusters are strongly reduced by ...
Wulffraat Nico M - - 2013
Introduction: Hitherto, some of the most severe forms of arthritis with onset in the neonatal period and early childhood have been resistant to conventional and anti-tumour necrosis factor agents. Recent results from drug trials of novel monoclonal antibodies will significantly alter the treatment of two of these diseases. This review ...
Jensen Stephen C - - 2013
The photofragmentation of butyrophenone yields benzoate and a propyl radical on oxidized TiO2(110). Oxygen dissociates in native oxygen vacancies to produce reactive oxygen adatoms which react with butyrophenone to create photoactive butyrophenone-O complexes that are sensitive to hole oxidation created upon UV illumination. The same O adatoms also trap one ...
Hayn Ernesto - - 2013
A foetal bovine dermal repair scaffold (PriMatrix, TEI Biosciences) was used to treat complex surgical or traumatic wounds where the clinical need was to avoid skin flaps and to build new tissue in the wound that could be reepithelialised from the wound margins or closed with a subsequent application of ...
Li Fuxiang - - 2013
Recently, magnons, which are quasiparticles describing the collective motion of spins, were found to undergo Bose-Einstein condensation (BEC) at room temperature in films of Yttrium Iron Garnet (YIG). Unlike other quasiparticle BEC systems, this system has a spectrum with two degenerate minima, which makes it possible for the system to ...
Zhang Xuming - - 2013
Plasmonic photocatalysis has recently facilitated the rapid progress in enhancing photocatalytic efficiency under visible light irradiation, increasing the prospect of using sunlight for environmental and energy applications such as wastewater treatment, water splitting and carbon dioxide reduction. Plasmonic photocatalysis makes use of noble metal nanoparticles dispersed into semiconductor photocatalysts and ...
Ito Taisuke - - 2013
Trichorhinophalangeal syndrome (TRPS) is an autosomal-dominant congenital hair loss disease characterized by sparse and slow-growing scalp hair, craniofacial and skeletal abnormalities, pear-shaped nose, thin upper lip, brittle and thin toenails, and bilateral brachydactyly of the big toes. We report a case of TRPS1 exhibiting these clinical features with a novel ...
Zhang Zhaoyang - - 2013
Extensive studies have been recently carried out to achieve dynamic control of cell-material interactions primarily through physicochemical stimulation. The purpose of this study was to apply reversible intermolecular hybridization to program cell-hydrogel interactions in physiological conditions based on DNA-antibody chimeras and complementary oligonucleotides. The results showed that DNA oligonucleotides could ...
Nottingham L K LK Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD, - - 2014
The inhibitor-κB kinase-nuclear factor-κB (IKK-NF-κB) and epidermal growth factor receptor-activator protein-1 (EGFR-AP1) pathways are often co-activated and promote malignant behavior, but the underlying basis for this relationship is unclear. Resistance to inhibitors of IKKβ or EGFR is observed in head and neck squamous cell carcinomas (HNSCC). Here, we reveal that ...
Kim Kwang Hyun - - 2013
OBJECTIVE: To more clearly elucidate the association between prostate volume and Gleason score (GS) upgrading. PATIENT AND METHODS: We reviewed 451 patients with prostate cancer with a GS of 6 on biopsy, who underwent radical prostatectomy without neoadjuvant treatment. As a preoperative variable, we assessed the independent effect of prostate ...
Whitfield Clare - - 2013
AIMS AND OBJECTIVES: To identify sources of information and support preferred by young people to understand adolescent practices as adolescents develop a sexual health knowledge base. BACKGROUND: Statistics suggest that adolescents are not always making safe sexual health decisions. It is essential to develop an understanding of preferred sources of ...
Sreenivasan Varun K A - - 2013
High-affinity molecular pairs provide a convenient and flexible modular base for the design of molecular probes and protein/antigen assays. Specificity and sensitivity performance indicators of a bioassay critically depend on the dissociation constant (KD ) of the molecular pair, with avidin:biotin being the state-of-the-art molecular pair (KD ∼ 1 fM) ...
Farhi A - - 2013
Objective: To evaluate the risk for congenital malformations diagnosed at birth following Assisted Reproductive Technology (ART) treatments compared with live births conceived spontaneously. Methods: A retrospective cohort study including 9,042 live births following ART and 213,288 spontaneously conceived live births during the period 1997-2004. The cohort was linked to the ...
Jdid R - - 2013
BACKGROUND: Sleep lines are caused by individual's sleeping positions and should be differentiated from expression wrinkles. OBJECTIVE: The aim of the study was to investigate possible risk factors for sleep lines on a sizeable sample of middle-aged Caucasian women. METHODS: This study involved a sample of 542 French middle-aged women ...
White Christopher R H - - 2013
BACKGROUND: Despite a growing body of evidence demonstrating the value of universal umbilical cord blood gas analysis (UCBGA), there remains reluctance in some maternity units to adopt universal testing. AIMS: Identify perceived barriers and benefits of universal UCBGA. METHODS: Medical and midwifery staff involved in intrapartum care at four level ...
Nadolna K - - 2013
In the present investigation a sample of 490 cod (Gadus morhua) was examined from three regions in the southern Baltic Sea (the Polish Exclusive Economic Zone, EEZ). Three species of anisakid nematodes with zoonotic potential, namely species of Contracaecum, Anisakis and Pseudoterranova, were found in the liver of cod, with ...
Yin Jinjin - - 2013
We present here a highly selective and sensitive label-free method to detect Hg2+ ions in aqueous solution by using DNA molecular machine-based fluorescent Ag nanoclusters (AgNCs). This mechanism is based on the Hg2+ ions triggering machine-like operations of DNA and the "product" of the machine being used to stabilize fluorescent ...
Sharma Anupma - - 2013
BACKGROUND: Tandem repeats are ubiquitous and abundant in higher eukaryotic genomes and constitute, along with transposable elements, much of DNA underlying centromeres and other heterochromatic domains. In maize, centromeric satellite repeat (CentC) and centromeric retrotransposons (CR), a class of Ty3/gypsy retrotransposons, are enriched at centromeres. Some satellite repeats have homology ...
Fairbrother Peter - - 2013
AIMS AND OBJECTIVES: To understand the views of patients and professionals on the acceptability and perceived usefulness of telemonitoring in the management of chronic heart failure in the context of day-to-day care provision. BACKGROUND: There is an increasing interest in the potential for telemonitoring to support the home-based management of ...
Bisson Patrick J - - 2013
The prism face of single crystal ice Ih has been studied using sum frequency vibrational spectroscopy focusing on identification of resonances in the hydrogen-bonded region. Several modes have been observed at about 3400 cm-1; each mode is both polarization and orientation dependent. The polarization capabilities of sum frequency generation (SFG) ...
Zoanetti Nathan - - 2013
BACKGROUND: Despite the widespread use of multiple-choice assessments in medical education assessment, current practice and published advice concerning the number of response options remains equivocal. This article describes an empirical study contrasting the quality of three 60 item multiple-choice test forms within the Royal Australian and New Zealand College of ...
He Zhangzhen - - 2013
K4Fe4P5O20 shows an interesting natrolite-like structure with a spin-tetrahedron lattice built by mixed valence Fe ions. Single crystals of the title compound are successfully grown by the flux method using KF as flux. Magnetic results combined from magnetic, heat capacity, and 57Fe Mössbauer spectra measurements show that K4Fe4P5O20 possesses a ...
Kim Dong Wook - - 2013
Purpose: To compare the risk of secondary cancer from scattered and leakage doses following intensity-modulated radiotherapy (IMRT), volumetric arc therapy (VMAT) and tomotherapy (TOMO) in patients with lung cancer. METHODS: IMRT, VMAT and TOMO were planned for five lung cancer patients. Organ equivalent doses (OEDs) are estimated from the measured ...
Qiu Guanyinsheng - - 2013
As valuable C1 building blocks, isocyanides represent an important class of reactive species and synthons. During the past decades, exhaustive efforts have been devoted to the discovery of highly efficient reactions involving isocyanide on the basis of the development of the Passerini and Ugi reactions. Several types of reactions involving ...
Imo Miriam - - 2013
The epidemiology of vector transmitted plant diseases is highly influenced by dispersal and the host-plant range of the vector. Widening the vector's host range may increase transmission potential, whereas specialization may induce specific disease cycles. The process leading to a vector's host shift and its epidemiological outcome is therefore embedded ...
van den Brom Charissa E - - 2013
Volatile anaesthetics exert protective effects on the heart against perioperative ischaemic injury. However, there is growing evidence that these cardioprotective properties are reduced in case of type 2 diabetes mellitus. A strong predictor of postoperative cardiac function is myocardial substrate metabolism. In the type 2 diabetic heart, substrate metabolism is ...
Frennesson Christina I - - 2013
Purpose:  To analyse a 3-year clinical patient cohort of ranibizumab treatment of exudative age-related macular degeneration (AMD), to investigate the impact on visual outcome of carrying forward the last acuity observation in drop-outs and to explore possible differences between the early and the late phase of the study. Methods:  A ...
González-Pérez Gabriela G Department of Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados del I.P.N. (CINVESTAV-IPN), Mexico City, - - 2013
The peripheral repertoire of CD4(+) T lymphocytes contains autoreactive cells that remain tolerant through several mechanisms. However, nonspecific CD4(+) T cells can be activated in physiological conditions as in the course of an ongoing immune response, and their outcome is not yet fully understood. Here, we investigate the fate of ...
Maurer Frauke - - 2013
sigma-Alkyl iridium hydride complexes are generally postulated as intermediates in iridium-catalyzed hydrogenation. Fast reductive elimination results in the formation of the hydrogenation product. With an beta-enamidoketone as unsaturated substrate, such an intermediate could be trapped, because the semihydrogenated product coordinates trifold to the iridium, generating a stable 18e--complex, which does ...
Lee Dongju - - 2013
The influence of surface modifications on the mechanical properties of epoxy-hexagonal boron nitride nanoflake (BNNF) nanocomposites is investigated. Homogeneous distributions of boron nitride nanoflakes in a polymer matrix, preserving intrinsic material properties of boron nitride nanoflakes, is the key to successful composite applications. Here, a method is suggested to obtain ...
Santavirta Nina - - 2013
This paper combined data collected from war time government records with survey data including background characteristics, such as factors that affected eligibility, to examine the adult depression outcomes of individuals who were evacuated from Finland to temporary foster care in Sweden during World War II. Using war time government records ...
Vogel Daphne Ys - - 2013
BACKGROUND: Macrophages play a dual role in multiple sclerosis (MS) pathology. They can exert neuroprotective and growth promoting effects but also contribute to tissue damage by production of inflammatory mediators. The effector function of macrophages is determined by the way they are activated. Stimulation of monocyte-derived macrophages in vitro with ...
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