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Dulisse Brian - - 2013
Abstract Objective: The objective of this study was to provide up-to-date estimates of the clinical and economic burden that occurs during inpatient treatment of cancer patients with febrile neutropenia (FN). Methods: A retrospective cohort study was conducted using 2007-2010 hospital discharge data from the Premier database. The study population included ...
Belguith-Maalej Salima - - 2013
Summary Intronic microsatellites repeats were implicated in the pathogenic mechanisms of several diseases. SLC26A4 gene, involved in the genetic susceptibility of autoimmune thyroid disease (AITD), harbours large non-coding introns. Using the tandem repeat finder (TRF) Software, two new polymorphic microsatellite markers, rs59736472 and rs57250751, located at introns 10 and 20, ...
Deagle Bruce E - - 2013
Threespine stickleback populations are model systems for studying adaptive evolution and the underlying genetics. In lakes on the Haida Gwaii archipelago (off western Canada), stickleback have undergone a remarkable local radiation and show phenotypic diversity matching that seen throughout the species distribution. To provide a historical context for this radiation, ...
Ploussard Guillaume - - 2013
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Even after a negative set of prostate biopsies, the risk of undetected prostate cancer remains clinically significant. Predictive markers of such a risk are undefined. In addition to PSA and PSAD, low prostate volume and %fPSA are interesting time-varying ...
Zhang Ying-Xiu - - 2013
Background: Prevalence of overweight and obesity has increased in both developed and developing countries. The increasing global prevalence of overweight and obesity among children and adolescents constitutes a public health crisis Aim: The present study assessed the rural-urban differences in prevalence of overweight and obesity among adolescents in Shandong Province, ...
Morioka Daichi - - 2013
Axillary osmidrosis often disturbs a person's social life, particularly in Asian countries. However, the clinical aspects of this condition have not been well documented in the English-language published work. This study aimed to provide information on the features of axillary osmidrosis, with a particular focus on sex differences. A retrospective ...
Liu Wei - - 2013
Perfusion deficits in patients with mild traumatic brain injury (TBI) from a military population were characterized by dynamic susceptibility contrast perfusion imaging. Relative cerebral blood flow (rCBF) was calculated by a model-independent deconvolution approach from the tracer concentration curves following a bolus injection of gadolinium diethylenetriaminepentaacetate (Gd-DTPA) using both manually ...
Pechanova Olga - - 2013
The filamentous fungus Aspergillus flavus is an opportunistic soil-borne pathogen that produces aflatoxins, the most potent naturally occurring carcinogenic compounds known. This work represents the first gel-based profiling analysis of A. flavus proteome and establishes a 2-D proteome map. Using 2-DE and MALDI-TOF-MSMS, we identified 538 mycelial proteins of the ...
Czaja Angela S - - 2013
PURPOSE: This study aims to perform a comparative safety study assessing the risk of ventricular arrhythmia, cardiac arrest, or sudden death among pediatric selective serotonin reuptake inhibitor (SSRI) users. METHODS: Using US claims data from 1997 to 2009, new pediatric (age < 18 years) users of SSRI monotherapy were identified. Adverse cardiac outcomes ...
Wang Baogang - - 2013
Versatile efforts have been made to improve the stability of graphite/ethylene glycol (EG) nanofluids. Primitively, non-dispersible graphite nanoparticles were converted to graphite oxide nanoparticles (GONs) by acid treatment. Although GONs could be well dispersed in EG, the GONs/EG nanofluids exhibited limited stability up to less than 1 day. And then, ...
Tillfors Maria - - 2013
Previous research has identified a subgroup of socially anxious adults who are both anxious and impulsive. To date, however, this subgroup has not been identified in adolescence. Therefore, in this study we aimed to identify this subgroup in a sample of adolescents. In addition, we hypothesized that this subgroup would ...
Won Ki-Bum - - 2013
BACKGROUND: Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis (SCA) according to diabetes status are scarce. METHODS: Surrogate markers of SCA, brachial--ankle pulse wave velocity (baPWV), and carotid intima--medial thickness ...
Amatore Muriel - - 2013
A new asymmetric [2+2+2] cycloaddition of diynes to sulfonimines under rhodium catalysis is described, providing the corresponding enantioenriched 1,2-dihydropyridines in good yields.
Ebrahimzadeh Homeira - - 2013
A rapid and simple quantitative method for preconcentration and determination of haloperidol in biological samples was developed using ultrasound-assisted emulsification microextraction, based on the solidification of floating organic droplet combined with high-performance liquid chromatography-diode array detection (HPLC-DAD). The effects of several factors were investigated. 30 μL of 1-undecanol as an ...
Rozot Virginie - - 2013
Protective immunity to Mycobacterium tuberculosis (Mtb) remains poorly understood and the role of Mtb-specific CD8+ T cells is controversial. Here we performed a broad phenotypic and functional characterization of Mtb-specific CD8+ T cells in 326 subjects with latent Mtb infection (LTBI) or active TB disease (TB). Mtb-specific CD8+ T cells ...
Vaze Koustubh M - - 2013
Circadian rhythms are believed to be an evolutionary adaptation to daily environmental cycles resulting from Earth's rotation about its axis. A trait evolved through a process of natural selection is considered as adaptation; therefore, rigorous demonstration of adaptation requires evidence suggesting evolution of a trait by natural selection. Like any ...
Kurjak Asim - - 2013
Abstract Aim. The aim was to assess the onset and the frequencies of the first intertwin contacts by four dimensional ultrasound (4D US) in the 1st trimester of pregnancy. In the second part of the study fetal behavior and Kurjak Antenatal Neurodevelopmental Test (KANET) score of twins compared to singletons ...
Hoffman Kevin W - - 2013
The amino acid histidine (His) has a number of unique roles that can dictate function in proteins, and these roles are typically conferred through noncovalent interactions that depend on the protonation state of His's 4-substituted imidazole ring. His's protonation state can vary near physiological pH, and a probe of His's ...
Song Guoxin - - 2013
A method based on dispersive liquid-liquid microextraction coupled with GC/MS was developed for quantitative analysis of the major organic pollutants listed in USEPA method 8270 and the 15 European-priority PAHs in coking wastewater. The major parameters such as extraction solvent, dispersive solvent, solution pH, and extraction time were systematically optimized. ...
Sah Raman Prasad - - 2013
We present an interesting case of a child with Marfan's syndrome with ectopia lentis, who was followed for five years. The changes in refractive and visual findings of this child during this period are discussed. The importance of careful oculo-visual examination and possible management options in such children are highlighted.
Kan-O Keiko - - 2013
BACKGROUND: Clinical studies showed the contribution of viral infection to the development of asthma. Although mast cells have multiple roles in the pathogenesis of allergic asthma, their role of in the virus-associated pathogenesis of asthma remains unknown. Most respiratory viruses generate double-stranded (ds) RNA during their replication. dsRNA provokes innate ...
Schwenkglenks Matthias - - 2013
ABSTRACT Febrile neutropenia (FN) is a common and serious complication of chemotherapy treatment. Clinical risk models may help identify high risk FN patients but must undergo external validation before implementation in medical practice. Therefore, this study externally validated previously published clinical models of FN occurrence during chemotherapy in 240 non-Hodgkin ...
French Amanda N - - 2013
PURPOSE: To examine the patterns of myopigenic activity (high near work, low time outdoors) in children growing up in Sydney, Australia, by age, ethnicity and gender. METHODS: The Sydney Adolescent Vascular and Eye Study (SAVES) re-examined children from the two age cohorts (6 and 12 years at baseline) from the Sydney ...
Egger Jan - - 2013
Volumetric change in glioblastoma multiforme (GBM) over time is a critical factor in treatment decisions. Typically, the tumor volume is computed on a slice-by-slice basis using MRI scans obtained at regular intervals. (3D)Slicer - a free platform for biomedical research - provides an alternative to this manual slice-by-slice segmentation process, ...
Zinchuk Vadim - - 2013
Quantitative colocalization studies suffer from the lack of unified approach to interpret obtained results. We developed a tool to characterize the results of colocalization experiments in a way so that they are understandable and comparable both qualitatively and quantitatively. Employing a fuzzy system model and computer simulation, we produced a ...
Fernandez Juan P - - 2013
Aims: To establish success and complication rates of excimer laser coronary atherectomy (ELCA) in a contemporary series of patients with balloon failure during percutaneous coronary intervention (PCI) of both chronic total occlusions (CTO) and lesions with distal TIMI 3 flow. Methods and results: We identified 58 cases of balloon failure ...
Santos H M - - 2013
In the present work we report a novel on-target protein cleavage method. The method utilizes ultrasonic energy and allows up to 20 samples to be cleaved in 5 minutes for protein identification and 1 sample in 30 s for on-tissue digestion. The standard proteins were spotted on a conductive glass ...
Dietz Hans Peter - - 2013
The investigation of female pelvic floor function and anatomy is moving from the fringes to the mainstream of urogynaecology and female urology, and it is becoming increasingly relevant for obstetrics. We are coming to realise that pelvic floor trauma in labour is common, usually overlooked, and a major factor in ...
Wang Zhong-Ming - - 2013
Zebrias zebrinus belongs in the family Soleidae of Pleuronectiformes. There are overlaps in the ranges of identification characters between Z. zebrinus and another striped sole Z. fasciatus. In this study, the complete mitochondrial genome of Z. zebrinus was first determined. The total length was 16,758 bp, including 13 protein-coding genes, 22 ...
Flydal Marte I - - 2013
Mammalian phenylalanine hydroxylase (PAH) catalyzes the rate-limiting step in the phenylalanine catabolism, consuming about 75% of the phenylalanine input from the diet and protein catabolism under physiological conditions. In humans, mutations in the PAH gene lead to phenylketonuria (PKU), and most mutations are mainly associated with PAH misfolding and instability. ...
Schmidt Carla - - 2013
Simple protein separation by one dimensional (1D) gel electrophoresis is a widely used method to reduce sample complexity and to prepare proteins for mass spectrometric identification via in-gel digestion. While several automated solutions are available for in-gel digestion particularly of small cylindric gel plugs derived from 2D gels, the processing ...
Gonzalez-Flores A - - 2013
Hypoxia-inducible factors (HIFs) mediate the transcriptional adaptation of hypoxic cells. The extensive transcriptional programm regulated by HIFs involves the induction of genes controlling angiogenesis, cellular metabolism, cell growth, metastasis, apoptosis, extracellular matrix remodeling and others. HIF is a heterodimer of HIF-α and HIF-β subunits. In addition to HIF-1α, HIF-2α has ...
Kowalczyk Keith J - - 2013
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Retrospective data have suggested an increased survival benefit for patients undergoing partial nephrectomy compared to radical nephrectomy, possibly as a result of the avoidance of long-term renalin sufficiency and subsequent sequelae. However, recent level-one evidence has questioned this benefit. ...
Xu Linru - - 2013
Visualization and detection of latent fingerprints (LFPs) on metal surfaces are of highly practical importance, e.g., in identifying gun cartridges. We report herein the visualization of LFPs on stainless steel surfaces by electrochemiluminescence (ECL). Since organic residues, such as fatty acids, in the fingerprint deposit make the underlying surface electrochemically ...
Sackett Loren C - - 2013
Introduced diseases can cause dramatic declines in-and even the loss of-natural populations. Extirpations may be followed by low recolonization rates, leading to inbreeding and a loss of genetic variation, with consequences on population viability. Conversely, extirpations may create vacant habitat patches that individuals from multiple source populations can colonize, potentially ...
Girolamo Francesco - - 2013
AIMS: Sporadic inclusion body myositis (s-IBM) is characterized by rimmed vacuole formation and misfolded protein accumulation. Intracellular protein aggregates are cleared by autophagy. When autophagy is blocked aggregates accumulate, resulting in abnormal rimmed vacuole formation. This study investigated the autophagy-lysosome pathway contribution to rimmed vacuole accumulation. METHODS: Autophagy was studied ...
Tsioli V - - 2013
Recurrent cervical sialoceles were diagnosed in four dogs associated with inadequate excision of the sublingual gland. Three dogs were managed by resection of the remnants of the sublingual gland via an oral approach. One dog was managed through a ventral approach as identification of the sublingual gland was not possible ...
Delaney Joshua P - - 2013
This study describes the synthesis of five novel C2-symmetric organocatalysts that facilitate the on-water asymmetric aldol reaction at low catalyst loading (1 mol%) without the use of additives. Each catalyst is composed of two diprolinamide units joined by a symmetric alkyl bridging group allowing for systematic modulation of catalytic site ...
Liu Xinran - - 2013
Extracellular polymeric substances (EPS) are expected to be an important source for the formation of mineral-organic associations in soil. Since such formations affect the composition of mobile and immobile organic matter as well as the reactivity of minerals, we investigated the composition of EPS before and after adsorption to goethite. ...
Ting Yuen Ha - - 2013
BACKGROUND: The data in the literature suggests that Methimazole (MMI)/Carbimazole (CMZ) embryopathy is rare. This study examined the incidence of CMZ embryopathy in the Hong Kong Chinese population and the factors associated with its development. METHODS: Of the 145 pregnant women with hyperthyroidism managed from 2008 to 2010, 29 (20%) ...
Ho Cherng-Rong - - 2013
We demonstrated a promising route to enhance the performance of inverted organic photovoltaic (OPV) devices by the incorporation of CuGaSe2 (CGS) quantum dots (QDs) into the ZnO buffer layer of P3HT:PCBM-based devices. The modification of QDs provides better band alignment between the organic/cathode interface, improves ZnO crystal quality, and increases ...
Verheyen Nicolas - - 2013
Effective therapeutic strategies are warranted to reduce the burden of parathyroid hormone excess related morbidity and mortality. The calcimimetic agent cinacalcet hydrochloride is a promising treatment strategy in hyperparathyroidism. This review provides an overview of the pharmacokinetics, clinical efficacy, cost-effectiveness, safety and the efficacy profile of cinacalcet in the setting ...
Punnen Sanoj - - 2013
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Previous studies have shown that robot-assisted radical prostatectomy (RARP) can be performed in men with high-risk prostate cancer with similar outcomes to that of open surgery. However, most of the literature consists of small case series and compares RARP ...
Ferrante Marc - - 2013
Introduction: The introduction of antibodies directed against tumour necrosis factor (anti-TNF) has dramatically changed the concept of treating patients with Crohn's disease (CD). Unfortunately, the long-term efficacy of anti-TNF agents may be hampered by immunogenicity. The availability of more anti-TNF agents in the therapeutic armamentarium would therefore be of great ...
Raadsma H W - - 2013
The pursuits of white features and white fleeces free of pigmented fibre have been important selection objectives for many sheep breeds. The cause and inheritance of non-white colour patterns in sheep has been studied since the early 19th century. Discovery of genetic causes, especially those which predispose pigmentation in white ...
Grieselhuber N R NR Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, - - 2013
Acute promyelocytic leukemia (APL) is initiated by the PML-RARA (PR) fusion oncogene and has a characteristic expression profile that includes high levels of the Notch ligand Jagged-1 (JAG1). In this study, we used a series of bioinformatic, in vitro, and in vivo assays to assess the role of Notch signaling ...
Keller Daniela - - 2013
Most landscape genetic studies assess the impact of landscape elements on species' dispersal and gene flow. Many of these studies perform their analysis on all possible population pairs in a study area and do not explicitly consider the effects of spatial scale and population network topology on their results. Here, ...
Haas Dietmar - - 2013
OBJECTIVE: To assess the extent to which the Enzian classification correlates with the revised American Society for Reproductive Medicine (rASRM) score and clinical symptoms in patients with deeply infiltrating endometriosis. DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: Endometriosis competence center specializing in minimally invasive surgery. PATIENTS: Between ...
Cribier B - - 2013
Rosacea is a common facial dermatosis that is seldom biopsied; thus, histological aspects have not been well described. Biopsies are generally performed in the presence of atypical symptoms (e.g. granulomas). Differential diagnosis with sarcoidosis, lupus miliaris or lupus erythematosus is another indication for biopsy. There are few published studies addressing ...
Choi Kyeong-Sook - - 2013
OBJECTIVE: Although engagement in productive activities is associated with favourable outcomes with respect to the health and well-being of older individuals, the association between such activities and depression in older populations remains relatively unexplored. The purpose of this study was to evaluate the association among five productive activities (paid work, ...
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