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Addison J Bennett JB Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604, USA. - - 2013
Adhesive silks spun by aquatic caddisfly (order Trichoptera) larvae are used to build both intricate protective shelters and food harvesting nets underwater. In this study, we use (13)C and (31)P solid-state NMR and wide angle X-ray diffraction (WAXD) as tools to elucidate molecular protein structure of caddisfly larval silk from ...
Wiemerslage Lyle L Neuroscience Program, Department of Biological Sciences, Ohio University, Athens, Ohio 45701, - - 2013
Drosophila melanogaster is widely used to study genetic factors causing Parkinson's disease (PD) largely because of the use of sophisticated genetic approaches and the presence of a high conservation of gene sequence/function between Drosophila and mammals. However, in Drosophila, little has been done to study the environmental factors which cause ...
Klema Valerie J VJ Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, - - 2013
Copper amine oxidases (CAOs) are responsible for the oxidative deamination of primary amines to their corresponding aldehydes. The CAO catalytic mechanism can be divided into two half-reactions: a reductive half-reaction in which a primary amine substrate is oxidized to its corresponding aldehyde with the concomitant reduction of the organic cofactor ...
Hines Kelly M KM Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United - - 2013
Wound fluid is a complex biological sample containing byproducts associated with the wound repair process. Contemporary techniques, such as immunoblotting and enzyme immunoassays, require extensive sample manipulation and do not permit the simultaneous analysis of multiple classes of biomolecular species. Structural mass spectrometry, implemented as ion mobility-mass spectrometry (IM-MS), comprises ...
Zhang Qun-Fang - - 2013
CobB is a bacterial NAD(+)-dependent protein deacetylase. Although progress has been made in functional studies of this protein in recent years, its substrates and biological functions are still largely unclear. Using proteome microarray technology, potential substrates of Escherichia coli CobB were screened and nine proteins were identified, including N-hydroxyarylamine O-acetyltransferase ...
Wu Jiahui J Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, - - 2013
We have used protein engineering to expand the palette of genetically encoded calcium ion (Ca(2+)) indicators to include orange and improved red fluorescent variants, and validated the latter for combined use with optogenetic activation by channelrhodopsin-2 (ChR2). These indicators feature intensiometric signal changes that are 1.7- to 9.7-fold improved relatively ...
Karuturi Rajesh R Department of Medicinal Chemistry and Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia 23298, - - 2013
To discover promising sulfated allosteric modulators (SAMs) of glycosaminoglycan-binding proteins (GBPs), such as human factor XIa (FXIa), we screened a library of 26 synthetic, sulfated quinazolin-4(3H)-ones (QAOs) resulting in the identification of six molecules that reduced the Vmax of substrate hydrolysis without influencing the KM. Mutagenesis of residues of the ...
Kim Min Hyeok MH SKKU Advanced Institute of Nanotechnology-SAINT, Sungkyunkwan University, Suwon 440-746, - - 2013
An elastic network model (ENM), usually Cα coarse-grained one, has been widely used to study protein dynamics as an alternative to classical molecular dynamics simulation. This simple approach dramatically saves the computational cost, but sometimes fails to describe a feasible conformational change due to unrealistically excessive spring connections. To overcome ...
Dickenson Nicholas E NE Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, Oklahoma 74078, - - 2013
The Shigella flexneri Type III secretion system (T3SS) senses contact with human intestinal cells and injects effector proteins that promote pathogen entry as the first step in causing life threatening bacillary dysentery (shigellosis). The Shigella Type III secretion apparatus (T3SA) consists of an anchoring basal body, an exposed needle, and ...
Zumer Kristina - - 2013
The autoimmune regulator is a critical transcription factor for generating central tolerance in the thymus. Recent studies have revealed how the autoimmune regulator targets many otherwise tissue-restricted Ag genes to enable negative selection of autoreactive T cells.
Hoffman James M - - 2013
Factors likely to influence drug expenditures, drug expenditure trends in 2012, and projected drug expenditures for U.S. nonfederal hospitals and clinics in 2013 are discussed. Prescription drug expenditure data for 2011 through September 2012 were obtained from the IMS Health National Sales Perspectives database. Expenditure projections were based on a ...
Cheville Andrea L - - 2013
This prospective cohort study was designed to determine whether the amount of radiation delivered to the nonpathological lymph nodes (LNs) that drain the arm can be significantly reduced by integrating single-photon emission computed tomography (SPECT)/computed tomography (CT) scans into radiation treatment planning. SPECT-CT scans were acquired for the 28 patients ...
Go Amy C - - 2013
Patient safety improvements and increased efficiencies achieved through the establishment of standardized protocols and order sets for selected antibiotic desensitization procedures are described. Errors in the ordering and administration of antimicrobial desensitization regimens can result in life-threatening complications. To enhance patient safety, the University of Colorado Hospital pharmacy department worked ...
Brizendine Christina E - - 2013
A probable case of drug reaction with eosinophilia and systemic symptoms (DRESS) associated with consecutive use of three medications for seizure control is reported. A 36-year-old woman was treated at a community hospital for a mild fever (37.9°C) and diffuse raised maculopapular rash with erythema. Three weeks previously, she had ...
Cersosimo Robert J - - 2013
Important developments in chemotherapy for advanced colorectal cancer over the past 15 years are reviewed, with an emphasis on the most recently published data from clinical trials of newer multidrug regimens, administration techniques, and dosing schedules. Eight agents are approved by the Food and Drug Administration (FDA) for use in ...
Fox Laura M - - 2013
The physical compatibility of various drugs with neonatal total parenteral nutrient (TPN) solution during simulated Y-site administration was evaluated. Study drugs were selected based on the lack of compatibility data with them and neonatal TPN solution and the frequency of use in a local neonatal unit. These drugs included amiodarone, ...
Chen Fu-Chao - - 2013
The compatibility and stability of butorphanol tartrate and droperidol in polyvinyl chloride (PVC) bags and glass bottles stored at 4°C and 25°C for up to 15 days were studied. Admixtures were assessed initially and for 15 days after preparation in PVC bags and glass bottles using 0.9% sodium chloride injection ...
Felix-Getzik Erika - - 2013
A case illustrating multiple considerations in choosing safe and effective dual antiplatelet therapy for a patient with a history of clopidogrel allergy-including concerns relating to a national drug shortage-is described. A 75-year-old woman required dual antiplatelet therapy (aspirin plus a thienopyridine) after a cardiac catheterization procedure; during a prior emergency ...
Ahn-Jarvis Jennifer H JH Department of Food Science and Technology, The Ohio State University, 110 Parker Building, 2015 Fyffe Court, Columbus, Ohio 43210, - - 2013
To modulate isoflavone aglycone composition within a soy functional food, soy ingredients were processed and evaluated in a soy bread system intended for clinical trials. A soy flour/soy milk mixture (SM) was boiled, fermented, steamed, or roasted prior to dough preparation. The isoflavone compositions of five processed SM and their ...
Yu Jing J Department of Chemical Engineering, University of California, Santa Barbara, California 93106, - - 2013
The underwater adhesion of marine mussels relies on mussel foot proteins (mfps) rich in the catecholic amino acid 3,4-dihydroxyphenylalanine (Dopa). As a side chain, Dopa is capable of strong bidentate interactions with a variety of surfaces, including many minerals and metal oxides. Titanium is among the most widely used medical ...
Marek Rachel F RF Department of Civil & Environmental Engineering, The University of Iowa, Iowa City, Iowa 52242, United - - 2013
East Chicago, Indiana is a heavily industrialized community bisected by the Indiana Harbor and Ship Canal, which volatilizes ~7.5 kg/yr polychlorinated biphenyls (PCBs). In contrast, the rural Columbus Junction, Iowa area has no known current or past PCB industrial sources. Blood from children and their mothers from these communities were ...
Gao Jinwei - - 2013
A silver nanowire network electrode (NNE) is designed and made inexpensively on the surface of textured silicon by J. W. Gao, Y. Wang, and co-workers on page 733. The NNE is formed by depositing and sintering silver nanoparticles on the textured silicon surface. The scanning electron microscope images show that ...
Jiang Wei W Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, - - 2013
The echinocandins are a small group of fungal N-acylated cyclic hexapeptides that are fungicidal for candida strains and fungistatic for aspergilli by targeting cell wall 1,3-β-glucan synthases. The side chains of all six amino acid building blocks have hydroxyl groups, including the nonproteinogenic 4R,5R-dihydroxy-Orn1, 4R-OH-Pro3, 3S,4S-dihydroxy-homoTyr4, and 3S-OH-4S-Me-Pro6. The echinocandin ...
Geissler Matthias - - 2013
Single-walled carbon nanotubes are used as doping agents to form thermo-active composites with an elastomeric block-copolymer. Thermal imaging reveals that the temperature response upon irradiation with NIR laser light is dependent (among other things) on the mass fraction of the nanotubes in the polymer matrix.
Das Rajat K RK UMR 5248 CBMN, CNRS-Université de Bordeaux-ENITAB, Institut Européen de Chimie et Biologie, 2 Rue Robert Escarpit, F-33607 Pessac, - - 2013
Microenvironments such as protein composition, physical features, geometry, and elasticity play important roles in stem cell lineage specification. The components of the extracellular matrix are known to subsequently assemble into fibrillar networks in vivo with defined periodicity. However, the effect of the most critical parameter, which involves the periodicity of ...
Gomes Renata S M RS CNC, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, - - 2013
Herein, we report the use of biodegradable nanoparticles (NPs) containing perfluoro-1,5-crown ether (PFCE), a fluorine-based compound (NP170-PFCE) with the capacity to track cells in vivo by magnetic ressonance imaging (MRI) and efficiently release miRNA. NP170-PFCE complexed with miRNAs accumulate whitin the cell's endolysosomal compartment and interact with higher frequency with ...
Halter Margaret Jordan - - 2013
The first major attempts to categorize psychiatric disorders in the United States occurred in the mid-1800s, when census data were collected that included "insanity" and "idiocy" of household members. In Europe, Florence Nightingale promoted the use of non-fatal disease classification for morbidity and treatment in 1860. By the late 1800s, ...
Ren Xiaochen - - 2013
An integrated organic temperature sensor with 10 bits dynamic range is reported by Paddy K.L. Chan and co-workers on page 1291. Inside the sensor, silver nanoparticles are inserted into the pentacene to enhance the temperature sensitivity of the thermistor. The high dynamic range of the sensor is attributed to the ...
Staude Isabelle - - 2013
A variety of gold nanostructures is fabricated using a novel fabrication approach that combines direct laser writing and electron-beam lithography. While preserving the nanoscopic feature sizes achievable with electron-beam lithography, this approach allows the realization of out-of plane metallic nanostructures, and thereby opens up new opportunities for metamaterials, nanoantennas, and ...
Jabri Salman Y SY Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, - - 2013
The first total synthesis of a member of the plectosphaeroic acid family of fungal natural products is reported. Key steps include the late-stage formation of the hindered N6-C9" bond and stereoselective introduction of the two methylthio substituents.
Halter Margaret Jordan - - 2013
Scheduled for publication in May 2013, the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), will guide clinical diagnoses, treatment plans, medication choices and protocols, insurance reimbursements, and research agendas throughout the United States. It will also serve as a reference manual for clinicians around the world. This ...
Warren Barbara Jones - - 2013
Reports regarding the proposed changes in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) indicate there will be expanded and more clearly defined mental health assessment information regarding culture and diversity. This change is in response to the concerns of educators, practitioners, and researchers regarding ...
Kunz Daniel A - - 2013
Forced undulations caused by a simple wrinkling process deliver unique insights into the mechanical performance of single graphene oxide nanoplatelets and related compounds with sub-micrometer resolution. This metrology is applied on page 1337 by Josef Breu, Andreas Fery, and co-workers to guide more homogeneous oxidation routes to graphene oxide and ...
Daien Vincent - - 2013
PURPOSE:The authors attempted to identify the determinants of ocular deviation in a population of patients with esotropia under general anesthesia. METHODS:Forty-one patients with esotropia were included. Horizontal ocular deviation was evaluated by the photographic Hirschberg test both in the awakened state and under general anesthesia before surgery. Changes in ocular ...
Budyak Ivan L IL Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA 01003, - - 2013
Protein folding and aggregation inevitably compete with one another. This competition is even keener for proteins with frustrated landscapes, such as those rich in β structure. It is interesting that, despite their rugged energy landscapes and high β sheet content, intracellular lipid-binding proteins (iLBPs) appear to successfully avoid aggregation, as ...
Shao Yaming Y Institute of Molecular Biophysics, Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, - - 2013
Clustered regularly interspaced short palindromic repeats (CRISPRs) confer adaptive immunity to prokaryotes through a small RNA-mediated mechanism. Specific endoribonucleases are required by all CRISPR-bearing organisms to process CRISPR RNAs into small RNA that serve as guides for defensive effector complexes. The molecular mechanism of how the endoribonucleases process the class ...
Kellett Whitney F WF Department of Chemistry, University of Florida, Gainesville, Florida 32611, United - - 2013
The fermentation-respiration switch (FrsA) protein in Vibrio vulnificus was recently reported to catalyze the cofactor-independent decarboxylation of pyruvate. We now report quantum mechanical/molecular mechenical calculations that examine the energetics of C-C bond cleavage for a pyruvate molecule bound within the putative active site of FrsA. These calculations suggest that the ...
Dunn Briana J BJ Department of Chemical Engineering, Stanford University, Stanford, California 94305, United - - 2013
Acyltransferase (AT) domains of modular polyketide synthases exercise tight control over the choice of α-carboxyacyl-CoA substrates, but the mechanistic basis for this specificity is unknown. We show that whereas the specificity for the electrophilic malonyl or methylmalonyl component is primarily expressed in the first half-reaction (formation of the acyl-enzyme intermediate), ...
Nilsson Anita - - 2013
AIMS AND OBJECTIVES: To develop a theoretical understanding of the processes hindering person-centred care of older people with cognitive impairment in acute care settings. BACKGROUND: Although person-centred care with its holistic focus on the biopsychosocial needs of patients is commonly considered the gold standard care for older people with cognitive ...
Mezzenga Raffaele - - 2013
The aggregation of proteins is of fundamental relevance in a number of daily phenomena, as important and diverse as blood coagulation, medical diseases, or cooking an egg in the kitchen. Colloidal food systems, in particular, are examples that have great significance for protein aggregation, not only for their importance and ...
Chen Ying - - 2013
In this study, we sequenced and annotated the complete mitochondrial genome of Schizothorax waltoni (Cypriniformes:Cyprinidae). The mitogenome is 16,587 bp in length, which contains 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes, and 2 non-coding regions: origin of light-strand replication (OL) and control region (D-loop). The overall nucleotide base composition ...
Chen Hongliang - - 2013
Molecular self-assembly is a promising technology for creating reliable functional films in optoelectronic devices with full control of thickness and even spatial resolution. In particular, rationally designed self-assembled monolayers (SAMs) play an important role in modifying the electrode/semiconductor and semiconductor/dielectric interfaces in field-effect transistors. Carbon nanomaterials, especially single-walled carbon nanotubes ...
Tran Huyen A HA Clinical Haematology, The Alfred Hospital, Melbourne, VIC. - - 2013
• Despite the associated bleeding risk, warfarin is the most commonly prescribed anticoagulant in Australia and New Zealand. Warfarin use will likely continue for anticoagulation indications for which novel agents have not been evaluated and among patients who are already stabilised on it or have severe renal impairment. • Strategies ...
Chuang Ying-Chih - - 2013
The single- and many-particle Coulomb excitation spectra in Bernal bilayer graphene can be modulated by a uniform perpendicular electric field. The field-induced oscillatory parabolic bands possess saddle points and local extrema, which, respectively, lead to logarithmically divergent peaks and discontinuous steps in the bare response functions. Such special structures are ...
Donnelly L - - 2013
Completeness of mast cell tumour (MCT) excision is determined by assessment of histologically tumour-free margins (HTFM). The HTFM width necessary to prevent local recurrence (LR), recognized as histologic safety margin (HSM) in human oncology, has not been defined. We hypothesized that HTFM width would correlate with risk for LR and ...
Anderson Cheryl A M CA Department of Family and Preventive Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA. - - 2013
By increasing blood folate concentrations, folic acid supplementation reduces risk for neural tube defect-affected pregnancies, and lowers homocysteine concentrations. We assessed response of red blood cell (RBC) and serum folate to folic acid supplementation, and examined association of response with the genetic polymorphism C677T of the methylenetetrahydrofolate NAD(P)H (MTHFR) gene. ...
Thai Hoai-Thu - - 2013
A version of the nonparametric bootstrap, which resamples the entire subjects from original data, called the case bootstrap, has been increasingly used for estimating uncertainty of parameters in mixed-effects models. It is usually applied to obtain more robust estimates of the parameters and more realistic confidence intervals (CIs). Alternative bootstrap ...
Guo Benchang - - 2013
B-cell receptor (BCR) signaling initiates multiple activities critical for B-cell function. Recently we identified an alternate BCR signaling pathway, induced by IL-4, that is signalosome-independent, unlike the classical signalosome-dependent pathway, and that leads to activation of the MAP kinase, ERK. Here we questioned whether alternate pathway signaling extends to other ...
Su Qi - - 2013
Tomato yellow leaf curl virus (TYLCV) was first detected in China in 2006, following the introduction of Bemisia tabaci Q into China in 2003. Since then, the incidence of TYLCV in tomato fields in China has greatly increased as has the abundance and distribution of Q whiteflies containing the bacterial ...
Jaworska Ewa - - 2013
A simple procedure leading to disposable potentiometric sensors using as a supporting electrode - electrical lead and transducer - a layer of carbon nanostructured material, either graphene or multi-walled nanotubes, is proposed, and the effect of the material used on the properties of the sensor is discussed. The obtained layers ...
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