Search Results
Results 101 - 150 of 5166
1 2 3 4 5 6 7 8 9 10 >
Wu Jiahui J Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, - - 2013
We have used protein engineering to expand the palette of genetically encoded calcium ion (Ca(2+)) indicators to include orange and improved red fluorescent variants, and validated the latter for combined use with optogenetic activation by channelrhodopsin-2 (ChR2). These indicators feature intensiometric signal changes that are 1.7- to 9.7-fold improved relatively ...
Karuturi Rajesh R Department of Medicinal Chemistry and Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia 23298, - - 2013
To discover promising sulfated allosteric modulators (SAMs) of glycosaminoglycan-binding proteins (GBPs), such as human factor XIa (FXIa), we screened a library of 26 synthetic, sulfated quinazolin-4(3H)-ones (QAOs) resulting in the identification of six molecules that reduced the Vmax of substrate hydrolysis without influencing the KM. Mutagenesis of residues of the ...
Kim Min Hyeok MH SKKU Advanced Institute of Nanotechnology-SAINT, Sungkyunkwan University, Suwon 440-746, - - 2013
An elastic network model (ENM), usually Cα coarse-grained one, has been widely used to study protein dynamics as an alternative to classical molecular dynamics simulation. This simple approach dramatically saves the computational cost, but sometimes fails to describe a feasible conformational change due to unrealistically excessive spring connections. To overcome ...
Dickenson Nicholas E NE Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, Oklahoma 74078, - - 2013
The Shigella flexneri Type III secretion system (T3SS) senses contact with human intestinal cells and injects effector proteins that promote pathogen entry as the first step in causing life threatening bacillary dysentery (shigellosis). The Shigella Type III secretion apparatus (T3SA) consists of an anchoring basal body, an exposed needle, and ...
Chen Fu-Chao - - 2013
The compatibility and stability of butorphanol tartrate and droperidol in polyvinyl chloride (PVC) bags and glass bottles stored at 4°C and 25°C for up to 15 days were studied. Admixtures were assessed initially and for 15 days after preparation in PVC bags and glass bottles using 0.9% sodium chloride injection ...
Go Amy C - - 2013
Patient safety improvements and increased efficiencies achieved through the establishment of standardized protocols and order sets for selected antibiotic desensitization procedures are described. Errors in the ordering and administration of antimicrobial desensitization regimens can result in life-threatening complications. To enhance patient safety, the University of Colorado Hospital pharmacy department worked ...
Zumer Kristina - - 2013
The autoimmune regulator is a critical transcription factor for generating central tolerance in the thymus. Recent studies have revealed how the autoimmune regulator targets many otherwise tissue-restricted Ag genes to enable negative selection of autoreactive T cells.
Hoffman James M - - 2013
Factors likely to influence drug expenditures, drug expenditure trends in 2012, and projected drug expenditures for U.S. nonfederal hospitals and clinics in 2013 are discussed. Prescription drug expenditure data for 2011 through September 2012 were obtained from the IMS Health National Sales Perspectives database. Expenditure projections were based on a ...
Cheville Andrea L - - 2013
This prospective cohort study was designed to determine whether the amount of radiation delivered to the nonpathological lymph nodes (LNs) that drain the arm can be significantly reduced by integrating single-photon emission computed tomography (SPECT)/computed tomography (CT) scans into radiation treatment planning. SPECT-CT scans were acquired for the 28 patients ...
Fox Laura M - - 2013
The physical compatibility of various drugs with neonatal total parenteral nutrient (TPN) solution during simulated Y-site administration was evaluated. Study drugs were selected based on the lack of compatibility data with them and neonatal TPN solution and the frequency of use in a local neonatal unit. These drugs included amiodarone, ...
Cersosimo Robert J - - 2013
Important developments in chemotherapy for advanced colorectal cancer over the past 15 years are reviewed, with an emphasis on the most recently published data from clinical trials of newer multidrug regimens, administration techniques, and dosing schedules. Eight agents are approved by the Food and Drug Administration (FDA) for use in ...
Felix-Getzik Erika - - 2013
A case illustrating multiple considerations in choosing safe and effective dual antiplatelet therapy for a patient with a history of clopidogrel allergy-including concerns relating to a national drug shortage-is described. A 75-year-old woman required dual antiplatelet therapy (aspirin plus a thienopyridine) after a cardiac catheterization procedure; during a prior emergency ...
Brizendine Christina E - - 2013
A probable case of drug reaction with eosinophilia and systemic symptoms (DRESS) associated with consecutive use of three medications for seizure control is reported. A 36-year-old woman was treated at a community hospital for a mild fever (37.9°C) and diffuse raised maculopapular rash with erythema. Three weeks previously, she had ...
Ahn-Jarvis Jennifer H JH Department of Food Science and Technology, The Ohio State University, 110 Parker Building, 2015 Fyffe Court, Columbus, Ohio 43210, - - 2013
To modulate isoflavone aglycone composition within a soy functional food, soy ingredients were processed and evaluated in a soy bread system intended for clinical trials. A soy flour/soy milk mixture (SM) was boiled, fermented, steamed, or roasted prior to dough preparation. The isoflavone compositions of five processed SM and their ...
Marek Rachel F RF Department of Civil & Environmental Engineering, The University of Iowa, Iowa City, Iowa 52242, United - - 2013
East Chicago, Indiana is a heavily industrialized community bisected by the Indiana Harbor and Ship Canal, which volatilizes ~7.5 kg/yr polychlorinated biphenyls (PCBs). In contrast, the rural Columbus Junction, Iowa area has no known current or past PCB industrial sources. Blood from children and their mothers from these communities were ...
Yu Jing J Department of Chemical Engineering, University of California, Santa Barbara, California 93106, - - 2013
The underwater adhesion of marine mussels relies on mussel foot proteins (mfps) rich in the catecholic amino acid 3,4-dihydroxyphenylalanine (Dopa). As a side chain, Dopa is capable of strong bidentate interactions with a variety of surfaces, including many minerals and metal oxides. Titanium is among the most widely used medical ...
Geissler Matthias - - 2013
Single-walled carbon nanotubes are used as doping agents to form thermo-active composites with an elastomeric block-copolymer. Thermal imaging reveals that the temperature response upon irradiation with NIR laser light is dependent (among other things) on the mass fraction of the nanotubes in the polymer matrix.
Jiang Wei W Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, - - 2013
The echinocandins are a small group of fungal N-acylated cyclic hexapeptides that are fungicidal for candida strains and fungistatic for aspergilli by targeting cell wall 1,3-β-glucan synthases. The side chains of all six amino acid building blocks have hydroxyl groups, including the nonproteinogenic 4R,5R-dihydroxy-Orn1, 4R-OH-Pro3, 3S,4S-dihydroxy-homoTyr4, and 3S-OH-4S-Me-Pro6. The echinocandin ...
Das Rajat K RK UMR 5248 CBMN, CNRS-Université de Bordeaux-ENITAB, Institut Européen de Chimie et Biologie, 2 Rue Robert Escarpit, F-33607 Pessac, - - 2013
Microenvironments such as protein composition, physical features, geometry, and elasticity play important roles in stem cell lineage specification. The components of the extracellular matrix are known to subsequently assemble into fibrillar networks in vivo with defined periodicity. However, the effect of the most critical parameter, which involves the periodicity of ...
Gomes Renata S M RS CNC, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, - - 2013
Herein, we report the use of biodegradable nanoparticles (NPs) containing perfluoro-1,5-crown ether (PFCE), a fluorine-based compound (NP170-PFCE) with the capacity to track cells in vivo by magnetic ressonance imaging (MRI) and efficiently release miRNA. NP170-PFCE complexed with miRNAs accumulate whitin the cell's endolysosomal compartment and interact with higher frequency with ...
Halter Margaret Jordan - - 2013
The first major attempts to categorize psychiatric disorders in the United States occurred in the mid-1800s, when census data were collected that included "insanity" and "idiocy" of household members. In Europe, Florence Nightingale promoted the use of non-fatal disease classification for morbidity and treatment in 1860. By the late 1800s, ...
Halter Margaret Jordan - - 2013
Scheduled for publication in May 2013, the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), will guide clinical diagnoses, treatment plans, medication choices and protocols, insurance reimbursements, and research agendas throughout the United States. It will also serve as a reference manual for clinicians around the world. This ...
Warren Barbara Jones - - 2013
Reports regarding the proposed changes in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) indicate there will be expanded and more clearly defined mental health assessment information regarding culture and diversity. This change is in response to the concerns of educators, practitioners, and researchers regarding ...
Jabri Salman Y SY Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, - - 2013
The first total synthesis of a member of the plectosphaeroic acid family of fungal natural products is reported. Key steps include the late-stage formation of the hindered N6-C9" bond and stereoselective introduction of the two methylthio substituents.
Daien Vincent - - 2013
PURPOSE:The authors attempted to identify the determinants of ocular deviation in a population of patients with esotropia under general anesthesia. METHODS:Forty-one patients with esotropia were included. Horizontal ocular deviation was evaluated by the photographic Hirschberg test both in the awakened state and under general anesthesia before surgery. Changes in ocular ...
Shao Yaming Y Institute of Molecular Biophysics, Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, - - 2013
Clustered regularly interspaced short palindromic repeats (CRISPRs) confer adaptive immunity to prokaryotes through a small RNA-mediated mechanism. Specific endoribonucleases are required by all CRISPR-bearing organisms to process CRISPR RNAs into small RNA that serve as guides for defensive effector complexes. The molecular mechanism of how the endoribonucleases process the class ...
Budyak Ivan L IL Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA 01003, - - 2013
Protein folding and aggregation inevitably compete with one another. This competition is even keener for proteins with frustrated landscapes, such as those rich in β structure. It is interesting that, despite their rugged energy landscapes and high β sheet content, intracellular lipid-binding proteins (iLBPs) appear to successfully avoid aggregation, as ...
Dunn Briana J BJ Department of Chemical Engineering, Stanford University, Stanford, California 94305, United - - 2013
Acyltransferase (AT) domains of modular polyketide synthases exercise tight control over the choice of α-carboxyacyl-CoA substrates, but the mechanistic basis for this specificity is unknown. We show that whereas the specificity for the electrophilic malonyl or methylmalonyl component is primarily expressed in the first half-reaction (formation of the acyl-enzyme intermediate), ...
Kellett Whitney F WF Department of Chemistry, University of Florida, Gainesville, Florida 32611, United - - 2013
The fermentation-respiration switch (FrsA) protein in Vibrio vulnificus was recently reported to catalyze the cofactor-independent decarboxylation of pyruvate. We now report quantum mechanical/molecular mechenical calculations that examine the energetics of C-C bond cleavage for a pyruvate molecule bound within the putative active site of FrsA. These calculations suggest that the ...
Rauschhuber Christina - - 2013
RNA interference (RNAi) is a key regulator of various biological systems including viral infection. Within a virus life cycle gene products can be modulated by the RNA interference (RNAi) pathway which can crucially impact productive virus replication. Herein we explored the RNA interference suppressor protein P19 derived from a plant ...
Arduino P G - - 2013
BACKGROUND: Oral lichen planus (OLP) is a chronic inflammatory disease, affecting nearly 1-2% of the population; Proposed therapies are usually symptomatic and numerous drugs have been used, but recently, it has been published that there is insufficient evidence to support the effectiveness of any specific treatment as being superior. To ...
Chan Pick Kuen - - 2013
Three independent ethylene insensitive mutants were selected from an EMS- mutagenized population of Lotus japonicus MG-20 (Miyakojima). The mutants, called 'Enigma', were mutated in the LjEIN2a gene from Lotus chromosome 1, sharing significant homology with Arabidopsis EIN2 (ethylene-insensitive2). All three alleles showed classical ethylene insensitivity phenotypes (e.g., Triple Response), but ...
Kavitha Thangavelu - - 2013
Graphene oxide (GO) was functionalized covalently with pH-sensitive poly(2-(diethylamino) ethyl methacrylate) (PDEA) by surface-initiated in situ atom transfer radical polymerization. The structure of the PDEA-grafted GO (GO-PDEA) were examined by Fourier-transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis and atomic force microscopy. The grafted PDEA ...
Egger Jan - - 2013
Volumetric change in glioblastoma multiforme (GBM) over time is a critical factor in treatment decisions. Typically, the tumor volume is computed on a slice-by-slice basis using MRI scans obtained at regular intervals. (3D)Slicer - a free platform for biomedical research - provides an alternative to this manual slice-by-slice segmentation process, ...
Haas Dietmar - - 2013
OBJECTIVE: To assess the extent to which the Enzian classification correlates with the revised American Society for Reproductive Medicine (rASRM) score and clinical symptoms in patients with deeply infiltrating endometriosis. DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: Endometriosis competence center specializing in minimally invasive surgery. PATIENTS: Between ...
Cribier B - - 2013
Rosacea is a common facial dermatosis that is seldom biopsied; thus, histological aspects have not been well described. Biopsies are generally performed in the presence of atypical symptoms (e.g. granulomas). Differential diagnosis with sarcoidosis, lupus miliaris or lupus erythematosus is another indication for biopsy. There are few published studies addressing ...
Choi Kyeong-Sook - - 2013
OBJECTIVE: Although engagement in productive activities is associated with favourable outcomes with respect to the health and well-being of older individuals, the association between such activities and depression in older populations remains relatively unexplored. The purpose of this study was to evaluate the association among five productive activities (paid work, ...
Jayasinghe Suwan N - - 2013
Recent years have seen interest in approaches for directly generating fibers and scaffolds following a rising trend for their exploration in the health sciences. In this review the author wishes to briefly highlight the many approaches explored to date for generating such structures, while underlining their advantages and disadvantages, and ...
Emilsson L - - 2013
BACKGROUND: Studies have shown an increased risk of ischaemic heart disease (IHD) in patients with coeliac disease (CD), despite the patients' lack of traditional IHD risk factors. AIM: To characterise IHD according to CD status. METHODS: Data on duodenal or jejunal biopsies were collected in 2006-2008 from all 28 pathology ...
Karuppagounder Saravanan S - - 2013
Hypoxia-inducible factor (HIF) mediates a broad, conserved adaptive response to hypoxia, and the HIF pathway is a potential therapeutic target in cerebral ischemia. This study investigated the mechanism by which in vitro ischemia (oxygen-glucose deprivation; OGD) affects canonical hypoxic HIF-1α stabilization. We validated the use of a reporter containing the ...
He Min - - 2013
Superhydrophobic porous surfaces with hydrophilic polymers adsorbed in pores are designed to control the coalescing behavior of microdroplets as well as their quick self-removal. The combination of chemical composition and surface structure are greatly important in the design of new materials for heat exchange, antifogging, and anti-icing.
Saunders Keith - - 2013
1 I. 1 II. 3 III. 5 IV. 8 9 References 9 SUMMARY: This review discusses the varying roles that have been played by many plant-viral regulatory sequences and proteins in the creation of plant-based expression systems and virus particles for use in nanotechnology. Essentially, there are two ways of ...
Liu Gang - - 2013
We have been developing the methodology to discriminate the handedness and diameter of single-walled carbon nanotubes (SWNTs) through molecular recognition using chiral diporphyrin nanotweezers. Although relatively small diameters of SWNTs (less than 1.0 nm) were recognized well, nanotweezers were not able to form stable complexes with the SWNTs having the ...
Hua Yawen - - 2013
Equilibrium geometries of AlnTi (n=2-24) clusters were studied using density-functional theory with generalized gradient approximation. The resulting geometries showed that the titanium atom remains on the surface of clusters for n<20, but is endohedrally doped from n=20. This structural transition confirms the previous experiment results obtained by studying their abilities ...
Lu Ying-Bo - - 2013
For the potential applications in spintronics, we examine systematically the electronic properties of group-V elements (X) doped ZnO to investigate the magnetic properties induced by X based on density functional theory calculations. Our results indicates that X atoms doped in the form of a substitutional X atom at an O ...
Gao Ya-Dong - - 2013
Objective. To investigate the role and underlying mechanisms of store-operated Ca2+ entry (SOCE) in mediating the promoting effect of transforming growth factor (TGF)-β1 on the proliferation of airway smooth muscle cells (ASMCs). Methods. Rat bronchial smooth muscle cells were cultured as we described previously. The intracellular Ca2+ concentration ([Ca2+]i)of ASMCs ...
Kanda Yoshinobu - - 2013
A previous Japanese study revealed that a human leucocyte antigen (HLA)-A or -B allele mismatch was associated with higher overall mortality, whereas an HLA-C or -DRB1 allele mismatch did not affect mortality after serologically matched unrelated bone marrow transplantation (BMT). This study reanalysed 3003 adult patients who underwent unrelated BMT ...
Wu Ji Hong - - 2013
We report a new capping-agent-free strategy for the synthesis of substrate-supported porous icosahedral Au nanoparticles (NPs) with rough naked surfaces, based on the crystallization from substrate-supported thin solution layers followed by solid-phase thermolysis. The plasmonic properties of icosahedral Au NPs have been studied using single particle dark-field scattering microscopy and ...
Sankoda Kenshi - - 2013
In this study, we hypothesize that natural photochemical reactions of polycyclic aromatic hydrocarbons (PAHs) in tidal flats are responsible for the occurrence of chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs). This study aims to survey the impact of photochemical reactions using a combination of field surveys and lab-scale experiments. Concentrations and profiles ...
Chen Jian - - 2013
BACKGROUND: Post-stroke hyperglycemia appears to be associated with poor outcome from stroke, greater mortality, and reduced functional recovery. Focal cerebral ischemia data support that neural stem cells (NSCs) play an important role in post-ischemic repair. Here we sought to evaluate the negative effects of hyperglycemia on the cellular biology of ...
1 2 3 4 5 6 7 8 9 10 >