Search Results
Results 1 - 50 of 2912
1 2 3 4 5 6 7 8 9 10 >
Maeda Hiroyuki - - 2013
Adenomyoepithelial adenosis of the breast is an extremely rare type of adenosis. We herein present the case of a 35-year-old woman, who presented with a small painless hard lump and elastic soft induration of 5 cm in diameter in her left breast. Clinical examination and diagnostic workup were suggestive of a ...
Derouiche Sandra - - 2013
Bisphenol A (BPA), the principal constituent of reusable water bottles, metal cans, and plastic food containers, has been shown to be involved in human prostate cancer (PCa) cell proliferation. The aim of the present study was to explore the effect of BPA on PCa cell migration and the pathways involved ...
Lafferty Kevin D - - 2013
Southern California's beaches can support a remarkable diversity of birds along the Pacific Flyway. We asked whether seasonal, annual, and spatial factors affect bird richness and abundance on public beaches. To do so, we conducted three years of monthly bird surveys on 12 sandy beaches in Ventura California. Across all ...
Russo Angelo - - 2013
Migraine is a complex disease whose physiopathological mechanisms are still not completely revealed. We describe an unusual case, not yet described in literature, of a patient who reported migraine remission, but still presented aura attacks, since starting a therapy with Warfarin. This case report brings out new questions on the ...
Peatfield Richard - - 2013
We report two patients who developed a prolonged featureless headache, they think after a drink was 'spiked'. We speculate that each was exposed to scopolamine, resulting in enhanced trigeminal release of vasodilator neuropeptides, including Calcitonin Gene-Related Peptide (CGRP), and thus the headache.
Padilla Carlos - - 2013
The objectives of this study were to detect genes for virulence and bacteriocins in addition to studying the antimicrobial susceptibility of 78 strains of E. faecalis isolated from water wells for human consumption. The virulence and bacteriocin genes of 78 E. faecalis were amplified by PCR and visualized in agarose ...
Coma Ermengol - - 2013
The development of electronic medical records has allowed the creation of new quality indicators in healthcare. Among them, synthetic indicators facilitate global interpretation of results and comparisons between professionals. A healthcare quality standard (EQA, the Catalan acronym for Estàndard de Qualitat Assistencial) was constructed to serve as a synthetic indicator ...
Hung Ivan F N - - 2013
Experience from influenza pandemics suggested that convalescent plasma treatment given within 4 to 5 days of symptom onset might be beneficial. However, robust treatment data are lacking. This is a multicenter, prospective, double-blind, randomized controlled trial. Convalescent plasma from patients who recovered from the 2009 pandemic influenza A(H1N1) (A[H1N1]) infection ...
Bauer Philippe R - - 2013
Interstitial lung disease (ILD) is a frequent complication of systemic sclerosis (SSc) and a major cause of SSc-related deaths. This study aimed to determine the influence of ILD on SSc in a population-based historical cohort study. The hypothesis was that patients with SSc who develop ILD have increased morbidity and ...
Natarajan Viswanathan V Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA. - - 2013
Acute lung injury (ALI) attributable to sepsis or mechanical ventilation and subacute lung injury because of ionizing radiation (RILI) share profound increases in vascular permeability as a key element and a common pathway driving increased morbidity and mortality. Unfortunately, despite advances in the understanding of lung pathophysiology, specific therapies do ...
Grau Maria M Department of Medicine, Columbia University Medical Center, New York, NY 10032, - - 2013
Severe COPD can lead to cor pulmonale and emphysema and is associated with impaired left ventricular (LV) filling. We evaluated whether emphysema and airflow obstruction would be associated with changes in right ventricular (RV) structure and function and whether these associations would differ by smoking status. The Multi-Ethnic Study of ...
Kaulich-Bartz Josee J Swiss Re Limited, Zurich, - - 2013
To increase equitable access to life insurance for HIV-positive individuals by identifying subgroups with lower relative mortality. Collaborative analysis of cohort studies. We estimated relative mortality from 6 months after starting antiretroviral therapy (ART), compared with the insured population in each country, among adult patients from European cohorts participating in ...
Vudattu Nalini K NK Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, - - 2013
To examine the role of immune dysregulation in antibiotic-refractory Lyme arthritis by comparing the phenotype, frequency, and function of CD4+ Teff cells and Treg cells in patients with antibiotic- responsive arthritis and patients with antibiotic-refractory arthritis. Matched peripheral blood and synovial fluid samples from 15 patients with antibiotic-responsive arthritis were ...
Akuthota Praveen P Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. - - 2013
Human eosinophils display directed chemotactic activity toward an array of soluble chemokines. Eosinophils have been observed to migrate to draining lymph nodes in experimental models of allergic inflammation, yet it is unknown whether eosinophils express CCR7, a key chemokine receptor in coordinating leukocyte trafficking to lymph nodes. The purpose of ...
Drake Matthew G MG Department of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR 97239, USA. - - 2013
Respiratory virus infections cause airway hyperreactivity (AHR). Preventative strategies for virus-induced AHR remain limited. Toll-like receptors (TLRs) have been suggested as a therapeutic target because of their central role in triggering antiviral immune responses. Previous studies showed that concurrent treatment with TLR2/6 and TLR9 agonists reduced lethality and the microbial ...
Prahalad Sampath S Emory University and Children's Healthcare of Atlanta, Atlanta, GA, - - 2013
Children with childhood-onset rheumatoid arthritis (RA) include those with rheumatoid factor or anti-citrullinated protein antibody-positive juvenile idiopathic arthritis. To test the hypothesis that adult-onset RA-associated variants are also associated with childhood-onset RA, we investigated RA-associated variants at 5 loci in a cohort of patients with childhood-onset RA. We also assessed ...
Yacoub Sophie S Department of Medicine, Imperial College, Hammersmith Campus, London, UK. - - 2013
Dengue is one of the most rapidly spreading vector-borne diseases in the world, with the incidence increasing 30-fold in the past 50 years. There are currently no licensed treatments or vaccines for dengue. This review covers the recent advances in our understanding of dengue pathogenesis, including host and viral determinants. ...
Ghazal Peter P Division of Pathway Medicine, University of Edinburgh, Edinburgh, UK. - - 2013
Sepsis is a serious complication in preterm and term infants, yet our understanding of how neonates respond to infection remains poorly defined. We describe our current clinical, cellular and molecular understanding of the neonatal host systemic response to infection. We find that host resilience essentially relies on innate immune mechanisms ...
Sufyan Ahmed S AS Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology– Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN 46290, - - 2013
Clinical management of nasal airway obstruction (NAO) in patients with and without nasal allergic symptoms and nasal valve collapse (NVC). To examine the impact that autologous alar batten grafts have on patients with NAO owing to NVC and their affect on nasal steroid use and allergic symptoms. A prospective study. ...
Wang Xiaonan H XH Renal Division, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA. - - 2013
To understand the impact of microRNA on myogenesis and muscle wasting in order to provide valuable information for clinical investigation. Muscle wasting increases the risk of morbidity/mortality in primary muscle diseases, secondary muscle disorders and elderly population. Muscle mass is controlled by several different signalling pathways. Insulin-like growth factor/PI3K/Akt is ...
Brugnara Carlo C Department of Laboratory Medicine, Children's Hospital Boston, Boston, Massachusetts 02115, USA. - - 2013
Measurements of red cell volume, hemoglobin (Hb) concentration and Hb content continue to play a crucial role in the differential diagnosis of anemias 80 years after the publication of Wintrobe's seminal work. Modern hematology analyzers provide additional data on the heterogeneity of these parameters (distribution width) and quantify similar parameters ...
Li Xiaohui X Cornea Genetic Eye Institute, Los Angeles, CA, - - 2013
Keratoconus (KC) is a genetically heterogeneous corneal dystrophy. Previously, we performed 2 genome-wide linkage scans in a 4-generation autosomal dominant pedigree and repeatedly mapped a KC locus to a genomic region located on chromosome 5q overlapping the gene encoding the inhibitor of calpains, calpastatin (CAST). To test whether variants in ...
Meyer Nuala J NJ Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. - - 2013
Acute respiratory distress syndrome (ARDS) behaves as a complex genetic trait, yet knowledge of genetic susceptibility factors remains incomplete. To identify genetic risk variants for ARDS using large scale genotyping. A multistage genetic association study was conducted of three critically ill populations phenotyped for ARDS. Stage I, a trauma cohort ...
Grotle Margreth M National resource center for rehabilitation in rheumathology, Diakonhjemmets Hospital, Oslo, Norway. - - 2013
In evaluating complex interventions, it is a challenge for researchers to provide transparent reporting of the intervention content with sufficient detail and clarity such that effects can be compared across studies or countries. To describe and compare the content of current rehabilitation for patients with inflammatory arthritis across 4 northern ...
Novak Richard R Program in Bioengineering, UC Berkeley, Berkeley, CA, USA. - - 2013
The production of hot embossed plastic microfluidic devices is demonstrated in 1-2 h by exploiting vinyl adhesive stickers as masks for electroplating nickel molds. The sticker masks are cut directly from a CAD design using a cutting plotter and transferred to steel wafers for nickel electroplating. The resulting nickel molds ...
Tang Elizabeth I - - 2013
During spermatogenesis, spermatids derived from meiosis simultaneously undergo extensive morphological transformation, to become highly specialized and metabolically quiescent cells, and transport across the seminiferous epithelium. Spermatids are also transported back-and-forth across the seminiferous epithelium during the epithelial cycle until they line up at the luminal edge of the tubule to ...
Li Hong H Laboratory of Respiratory Biology, Division of Intramural Research, National Institutes of Health/National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, - - 2013
Helper CD4(+) T cell subsets, including IL-9- and IL-10-producing T helper cell type 9 (Th9) cells, exist under certain inflammatory conditions. Cyclooxygenase (COX)-1 and COX-2 play important roles in allergic lung inflammation and asthma. It is unknown whether COX-derived eicosanoids regulate Th9 cells during allergic lung inflammation. To determine the ...
Ryan John J JJ Section of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, - - 2013
Pulmonary arterial hypertension (PAH) is a lethal, female-predominant, vascular disease. Pathologic changes in PA smooth muscle cells (PASMC) include excessive proliferation, apoptosis-resistance, and mitochondrial fragmentation. Activation of dynamin-related protein increases mitotic fission and promotes this proliferation-apoptosis imbalance. The contribution of decreased fusion and reduced mitofusin-2 (MFN2) expression to PAH is ...
Hahn Michael E ME Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, - - 2013
Polymers of norbornenyl-modified peptide-based enzyme substrates have been prepared via ring-opening metathesis polymerization (ROMP). Peptides displayed on water-soluble homopolymers retain the ability to be enzymatically processed by a disease-associated enzyme. In contrast, when the peptides are densely arrayed on a nanoparticle derived from a self-assembled amphiphilic block-copolymer, they function with ...
Lai Zaizhi Z Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794, - - 2013
Protein folding is one of the most fundamental problems in modern molecular biology. Uncovering the detailed folding mechanism requires methods that can monitor the structures at high temporal and spatial resolution. Two-dimensional infrared (2DIR) spectroscopy is a new tool for studying protein structures and dynamics with high time resolution. Using ...
Reeves Jerry - - 2013
We compared the impacts on total costs, health, and satisfaction among 615 adults enrolled 2 years in an employer's health home benefit plan to their baseline year in a standard preferred provider organization plan. The new plan combined strong continuity care incentives with nurse coaching support. After 24 months, total ...
Majeed Azeem - - 2013
A well-established primary care sector has allowed England's National Health Service (NHS) to make efficient use of resources through the gatekeeping role that general practitioners have in controlling access to specialist services. Because of the poor economic situation in the United Kingdom, there is now considerable pressure on the NHS ...
Davidson Stephen M - - 2013
Efforts to influence utilization of services to bring down spending and to improve quality of care have largely failed. A critical reason is that most attention has focused on dysfunctional financial incentives without considering other factors that also influence physicians' utilization decisions. In this article, after providing a framework for ...
Borkowski Nancy - - 2013
Change interventions in one form or another are viewed as important tools to reduce variation in medical services, reduce costs, and improve quality of care. With the current focus on efficient resource use, the successful design and implementation of change strategies are of utmost importance for health care managers. We ...
Fuller Richard L - - 2013
We examine impacts of age, payer, and mental health conditions upon hospital readmissions and the comparability of same-hospital and multiple-hospital readmission rates. Medicaid primary payment and extreme age are associated with significantly higher readmission rates. We find low correlation between same-hospital and multiple-hospital readmission rates and identify urban hospitals with ...
Tsui Edison W - - 2013
Many small- and medium-sized physician practices have developed specific programs and models toward becoming a successful patient-centered medical home. This article reports on a case-control quality improvement study of a multilingual population health management program for chronic disease management at International Community Health Services. In its first 2.5 years of ...
Salant Talya - - 2013
Beginning in 2007, a community health center and a community health worker organization collaborated on a community health worker initiative to improve diabetes outcomes among underserved communities. Despite a shared vision, the initiative ended prematurely because of a number of unexpected collaborative challenges. This article describes the results of a ...
Vianna Fernanda S L - - 2013
Thalidomide is the best-known teratogen worldwide. It was first marketed as a sedative in the late 1950s, but the birth of ∼10 000 children with birth defects resulted in the withdrawal of thalidomide from the market in 1962. Thalidomide embryopathy affects almost all organs but the main defects are concentrated ...
Vaysse Charlotte - - 2013
The outcome of patients presenting with vaginal melanoma has been assessed in a large multicentric retrospective study. The databases of 12 French institutions were searched for primary vaginal melanomas managed between 1990 and 2007. Among the 54 patients recorded, 46 were managed with a curative intent and included in the ...
Kodaganur Srinivas G - - 2013
The objective of this study was to report the clinical phenotype and genetic analysis of two Indian families with Escobar syndrome (ES). The diagnosis of ES in both families was made on the basis of published clinical features. Blood samples were collected from members of both families and used in ...
Fernandopulle Rushika - - 2013
While most approaches to improving primary care delivery involve making incremental improvements to existing practices, for the past decade we have been engaged in a different approach-to build new practices from the ground up to demonstrate a vision of what is possible. Our Iora model of care combines a new ...
Romanowski Eric G - - 2013
Swimming pools can be a vector for transmission of adenovirus ocular infections. Polyhexamethylene biguanide (PHMB) is a disinfectant used in swimming pools and hot tubs. To determine whether PHMB is an effective disinfectant against ocular adenovirus serotypes at a concentration used to disinfect swimming pools and hot tubs. In vitro ...
Tobias Jonathan H JH University of Bristol and Avon Orthopaedic Centre, Southmead Hospital, Bristol, UK. - - 2013
To determine whether joint hypermobility (JH) in childhood is a risk factor for the subsequent development of musculoskeletal pain. JH was determined according to the Beighton score at age 13.8 years in children from the Avon Longitudinal Study of Parents and Children (ALSPAC), using a cutoff of ≥6 for the ...
Uchida Naoya N Molecular Genetics, Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, 113-8602 Japan. - - 2013
Lentiviral vectors, including double internal promoters, can be used to express two transgenes in a single vector construct; however, transcriptional activities from double internal promoters are often inhibited by promoter interference. To determine whether the chicken hypersensitivity site 4 insulator (cHS4) could block promoter interference, lentiviral vectors including an MSCV-U3 ...
Ngo Linh T LT Genetics Area Program, University of Missouri, Columbia, MO 65211, - - 2013
Natural products and related structures are essential sources of new pharmaceuticals, because of the immense variety of functionally relevant secondary metabolites of microbial and plant species. Furthermore, the development of powerful analytical tools based upon genomics, proteomics, metabolomics, bioinformatics and other 21st century technologies are greatly expediting identification and characterization ...
Hou Jason K JK Houston VA HSR&D Center of Excellence, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA. - - 2013
Temporal trends in incidence and prevalence of Crohn's disease (CD) and ulcerative colitis (UC) in the United States have been reported only in regional populations. The Veterans Affairs (VA) health care system encompasses a national network of clinical care facilities. The aim of this study was to identify temporal trends ...
Dru┼╝bicki Mariusz M Institute of Physiotherapy, University of Rzeszów, 35-205 Rzeszow, Poland. - - 2013
The aim of this study was to assess gait in children with spastic diplegic cerebral palsy rehabilitated with the use of Lokomat active orthosis. A randomized controlled trial. Fifty-two children with spastic diplegic cerebral palsy. Temporospatial parameters of gait and selected kinematic parameters were assessed. Children from the study group ...
Magnusson Lina L Department of Rehabilitation, School of Health Sciences, Jönköping University and Swedish Institute for Disability Research, P.O. Box 1026, SE-551 11 Jönköping, Sweden. - - 2013
To investigate patients' mobility and satisfaction with their lower limb prosthetic or orthotic device and related service delivery in Malawi and to compare groups of patients regarding type and level of device and demographics. Questionnaires were used to collect self-report data from 83 patients. Ninety percent of prostheses or orthoses ...
Elbers Roy G RG University of Applied Sciences Leiden, P.O. BOX 382, 2300 AJ Leiden, The Netherlands. - - 2013
To investigate the predictive value of gait speed for community walking in Parkinson's disease and to develop a multivariate prediction model for community walking. Data from baseline assessments in a randomized clinical trial were used. Subjects: A total of 153 patients with Parkinson's disease were included. Community walking was evaluated ...
Lisboa Renato R Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, CA 92093, - - 2013
It is reasonable to hypothesize that for 2 patients with similar degrees of integrated binocular visual field (BVF) loss, the patient with a history of faster disease progression will report worse vision-related quality of life (VRQOL) than the patient with slowly progressing damage. However, to our knowledge, this hypothesis has ...
1 2 3 4 5 6 7 8 9 10 >