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Results 401 - 450 of 2911
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Song Sukhyun - - 2013
Cells are inherently exposed to a number of different biophysical stimuli such as electric fields, shear stress, and tensile or compressive stress from the extracellular environment in vivo. Each of these biophysical cues can work simultaneously or independently to regulate cellular functions and tissue integrity in both physiological and pathological ...
Vyhlidal Carrie A - - 2013
BACKGROUND: Differences in mRNA expression for inflammatory markers have been observed between subjects with asthma vs. controls and in relation to corticosteroid response. However, these studies utilized methods (e.g., bronchoscopy) that are too invasive to be used routinely in children and in the clinic. The primary purpose of this study ...
Nishimura Hiroaki - - 2013
Peripheral arterial disease (PAD) is very common in dialysis patients, who tend to have diffuse calcification and severe peripheral arterial stenosis that make it difficult to treat limbs using only surgical or endovascular interventions. Better ways to treat this condition are therefore required and also follow-up studies to evaluate the ...
Rebolledo B J - - 2013
This is a prospective randomised study comparing the clinical and radiological outcomes of uni- and bipedicular balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures. A total of 44 patients were randomised to undergo either uni- or bipedicular balloon kyphoplasty. Self-reported clinical assessment using the Oswestry Disability Index, the ...
Habek Mario - - 2013
Evidence suggests that brainstem involvement in multiple sclerosis (MS) is one of the major predictive factors for future disability. Recent work demonstrates that brainstem pathology is more frequent than can be depicted either clinically or with the use of MRI. Evoked potentials have been shown to reliably predict disability in ...
Russell-Babin Kathleen Ann - - 2013
Delirium is a frequent complication in the surgical experience of elderly hip surgery patients. Its impact can be severe and may even include death. Implementation of a delirium predictor tool might focus attention on early recognition of delirium, thereby potentially decreasing its impact. A related aim is to evaluate best ...
Conrad Rachel - - 2013
The liver is a common site for metastatic malignancies, particularly from the gastrointestinal tract. It also may be involved by primary neoplasms, both benign and malignant. Cytopathologic examination of mass lesions of the liver with pertinent use of ancillary studies is a useful method of establishing a correct diagnosis for ...
Rishel Cindy J - - 2013
The average age of the active nursing force in the United States is approaching 50 years (U.S. Department of Health and Human Services, 2010). Nurses are retiring at a rapid rate; 55% of respondents to one survey indicated a plan to retire in the next seven years (Sverdlik, 2012). Of ...
Feuillet-Palma Cheryl - - 2013
A key issue in modern photonics is the ability to concentrate light into very small volumes, thus enhancing its interaction with quantum objects of sizes much smaller than the wavelength. In the microwave domain, for many years this task has been successfully performed by antennas, built from metals that can ...
Onder Halil ─░brahim - - 2013
ABSTRACT Tamoxifen is a selective estrogen receptor modulator widely used in the treatment of hormone-responsive breast cancer. Tamoxifen-induced ocular complications are very rare. A post-menopausal woman with carcinoma of the left breast had presented with sudden loss of vision. The patient had been on tamoxifen therapy 20 mg daily for the ...
Hirasawa Tatsuya - - 2013
The evolutionary origin of the diaphragm remains unclear, due to the lack of a comparable structure in other extant taxa. However, recent researches into the developmental mechanism of this structure have yielded new insights into its origin. Here we summarize current understanding regarding the development of the diaphragm, and present ...
Meex Ingrid - - 2013
INTRODUCTION: Current monitoring during cardiopulmonary resuscitation (CPR) is limited to clinical observation of consciousness, breathing pattern and presence of a pulse. At the same time, the adequacy of cerebral oxygenation during CPR is critical for neurological outcome and thus survival. Cerebral oximetry, based on near-infrared spectroscopy (NIRS), provides a measure ...
Wallingford John B - - 2013
Human birth defects are a major public health burden: The Center for Disease Control estimates that 1 of every 33 United States newborns presents with a birth defect, and worldwide the estimate approaches 6% of all births. Among the most common and debilitating of human birth defects are those affecting ...
Cham Kwang M - - 2013
We examined factors influencing perceptual stability in observers with fusion maldevelopment nystagmus syndrome (FMNS). In addition, we also investigated the effect of visual demand, task-related physiologic stress, and motivation on the nystagmus waveform. Perception of oscillopsia during daily activities was assessed via a questionnaire. Perception of oscillopsia in the laboratory ...
Chen Hao - - 2013
We sought to better characterize the intravitreal profile of different triamcinolone formulations. The study was performed in vitro and in vivo. Kenalog-40, Triesence, and Transton were characterized for ocular pharmacokinetics, particle size, crystallinity, and dissolving kinetics in vitreous following an intravitreal injection into 12 rabbit eyes. The relationship of free ...
Beryozkin Avigail - - 2013
We evaluated the role of Crumbs homolog 1 (CRB1) in autosomal recessive (AR) retinal diseases in the Israeli and Palestinian populations using homozygosity mapping. Clinical analysis included family history, ocular examination, full-field electroretinography (ERG), and funduscopy. Molecular analysis included homozygosity mapping using whole genome single nucleotide polymorphism (SNP) arrays and ...
Chung Sook Hyun - - 2013
Müller cells, the principal glial cells in the mammalian retina, play an important role in the maintenance of retinal homeostasis. Recent reports suggest that Müller-cell dysfunction may contribute to the pathogenesis of retinal diseases such as idiopathic macular telangiectasia type 2. In the present study, we used microarray to compare ...
Niyadurupola Nuwan - - 2013
There is evidence implicating ischemia and excitotoxicity in the pathogenesis of glaucoma. ATP-mediated excitotoxicity via activation of the P2X7 receptor (P2X7R) has been proposed to play a role in retinal ganglion cell (RGC) degeneration in this disease. The aim of this research was to determine whether stimulation of the P2X7R ...
Sim Dawn A - - 2013
To investigate the impact of diabetic macular ischemia (DMI) on visual acuity (VA), through the analysis of novel fluorescein angiography (FA) parameters. Data were retrospectively collected over a 6-month period. DMI severity was graded using Early Treatment Diabetic Retinopathy Study (ETDRS) protocols. Custom software was used to quantify areas of ...
van Oterendorp Christian - - 2013
Retinal ganglion cells (RGC) are a relatively small cell population in the retina. This leads to an unfavorable signal-to-noise ratio when analyzing RGC proteins in whole retina lysate. We present a novel technique to obtain RGC-enriched rat retinal lysate by removing the outer retinal layers with an excimer laser before ...
Mari Jean Martial - - 2013
We improved the visibility of the lamina cribrosa (LC), including its posterior boundary, in optical coherence tomography (OCT) images of the human optic nerve head (ONH). An adaptive compensation algorithm was developed to overcome a limitation of our standard compensation algorithm, that is the overamplification of noise at high depth. ...
Anders Hans-Joachim - - 2013
In lupus erythematosus, elevated serum creatinine levels and urinary abnormalities implicate a kidney disorder, which may not always be lupus nephritis as defined by the current classification of the International Society of Nephrology/Renal Pathology Society. The signs of renal dysfunction may be caused by lupusunrelated renal injury such as drug ...
Olchawa Magdalena M - - 2013
To determine whether previously shown photodynamic (PD)-induced inhibition of specific photoreceptor outer segment (POS) phagocytosis by ARPE-19 cells is associated with reductions in receptor proteins mediating POS phagocytosis, and if PD treatment with merocyanine-540 (MC-540) produces additional effects leading to its inhibition of nonspecific phagocytosis. ARPE-19 cells preloaded with MC-540 ...
McCloskey Manabu - - 2013
Inhibiting VEGF improves adult retino/choroido-vascular diseases, but can lead to recurrent intravitreous neovascularization (IVNV), avascular retina (AVA), and retinal detachment in preterm infants with retinopathy of prematurity (ROP). We sought to understand causes of late-onset IVNV and AVA following anti-VEGF using an ROP model. In the Penn model of ROP, ...
Goudemand N - - 2013
Sun et al. (Reports, 19 October 2012, p. 366) reconstructed Permian to Middle Triassic equatorial seawater temperatures. After correct temporal positioning of their data points, their presumed trends of temperature changes, and hence their assumption of a one-to-one relationship between putative "lethally hot" seawater temperatures and a disputable equatorial "eclipse" ...
Zhao Guanjia - - 2013
Self-propelled catalytic microjets have attracted considerable attention in recent years and these devices have exhibited the ability to move in complex media. The mechanism of propulsion is via the Pt catalysed decomposition of H2O2 and it is understood that the Pt surface is highly susceptible to poisoning by sulphur-containing molecules. ...
Di Minno Matteo Nicola Dario - - 2013
The usefulness of anticoagulation in patients with atrial fibrillation (AF) is well known. However, the inherent limitations of vitamin K antagonists (VKAs) have made the development of new oral anticoagulants necessary. Drugs directed against thrombin or the factor Xa are currently available. These molecules, being administered at fixed doses and ...
Leak Ashley - - 2013
To examine demographic and disease characteristics by age and the moderating effect of age on quality of life (QOL) among non-Hodgkin lymphoma (NHL) survivors. A cross-sectional, secondary analysis study of NHL survivors. Two North Carolina cancer registries. 741 NHL survivors with a mean age of 62 years and a mean ...
Lee Jiyeon - - 2013
To evaluate the effect of ginger as an antiemetic modality for the control of chemotherapy-induced nausea and vomiting (CINV). Databases searched included MEDLINE® (PubMed), Embase, CINAHL®, Cochrane Central Register of Controlled Trials, Korean Studies Information Service System, Research Information Sharing Service by the Korean Education and Research Information Service, and ...
Spoelstra Sandra L - - 2013
To examine whether a history of cancer increased the likelihood of a fall in community-dwelling older adults, and if cancer type, stage, or time since diagnosis increased falls. A longitudinal, retrospective, cohort study. A home- and community-based waiver program in Michigan. 862 older adults aged 65 years or older with ...
Machida Mayumi - - 2013
Controllable stress, modeled by escapable shock (ES), can produce significant alterations in post-stress sleep, including increased rapid eye movement (REM) sleep. Recent work has demonstrated that post-stress sleep may be influenced by stressor predictability, modeled by predictive auditory cues. In this study, we trained mice with ES, either signaled (SES) ...
Suh Sooyeon - - 2013
This is a population-based longitudinal study that followed insomnia symptoms over a 6-year period in non-depressed individuals. The purpose of the study was to (1) investigate the longitudinal course of depression based on number of insomnia episodes; and (2) describe longitudinal associations between insomnia and depression, and insomnia and suicidal ...
Iwanir Shachar - - 2013
The nematode C. elegans develops through four larval stages before it reaches adulthood. At the transition between stages and before it sheds its cuticle, it exhibits a sleep-like behavior during a stage termed lethargus. The objectives of this study were to characterize in detail behavioral patterns and physiological activity of ...
Randerath Winfried J - - 2013
The clear discrimination of central and obstructive hypopneas is highly relevant to avoid misinterpretation and inappropriate treatment of complicated breathing patterns. Esophageal manometry is the accepted standard for the differentiation of the phenotypes of sleep apnea. However, it is limited in its use due to poor acceptance by patients and ...
Brown Elizabeth C - - 2013
To characterize tongue and lateral upper airway movement and to image tongue deformation during mandibular advancement. Dynamic imaging study of a wide range of apnea hypopnea index (AHI), body mass index (BMI) subjects. Not-for-profit research institute. 30 subjects (aged 31-69 y, AHI 0-75 events/h, BMI 17-39 kg/m(2)). Subjects were imaged ...
Casaluce Francesca - - 2013
Mitosis is the key event of the cell cycle, and microtubules play an important part in an array of cellular functions besides mitosis, including maintenance of cell shape, cell locomotion, and the movement of intracellular organelles. Various anti-microtubule agents interfere with normal progression of mitosis, such as taxanes and vinca ...
Gaston-Johansson Fannie - - 2013
To (a) examine coping capacity, psychological distress, spiritual well-being, positive and negative religious coping, and coping strategies among African American (AA) women with breast cancer, and (b) explore relationships among these variables to enhance an already tested comprehensive coping strategy program (CCSP) intervention for AA women with breast cancer (CCSP-AA). ...
Menshadi Neveen - - 2013
To investigate the effect of learned resourcefulness on fatigue symptoms in patients with non-Hodgkin lymphoma (NHL) receiving chemotherapy. Quasi-experimental with repeated measures. Two large hospitals in Israel. 46 patients with NHL. On the first day of a cycle of chemotherapy treatment, participants completed questionnaires assessing fatigue and learned resourcefulness. Fatigue ...
Karvinen Kristina H - - 2013
To explore relationships among quality of life (QOL), stress reactivity, health behaviors, and compliance to medical care in breast cancer survivors. One-time descriptive laboratory study. A visual motor laboratory at a rural university in the southeastern United States. 25 breast cancer survivors. Participants were subjected to the Trier Social Stress ...
Chao Hui-Lin - - 2013
To evaluate the effectiveness of ST-36 (Zusanli) acupressure on recovery of postoperative gastrointestinal function in patients with colorectal cancer. A longitudinal, randomized, controlled trial design. An urban medical center in Taiwan. 60 patients with colorectal cancer who had undergone abdominal surgery. Patients were randomly assigned to two groups, the ST-36 ...
Kano Taro - - 2013
To develop an instrument to assess the specific symptoms of chemotherapy-induced taste alterations. Cross-sectional study. Two outpatient chemotherapy centers in Kanto, Japan. Convenience sample of 214 adult patients with chemotherapy-induced taste alterations. Items on the chemotherapy-induced taste alteration scale (CiTAS) were developed by a qualitative study of patients with taste ...
Young Laura R - - 2013
Patients with obstructive sleep apnea/hypopnea syndrome (OSAHS), even those generally compliant with CPAP therapy, often intermittently discontinue CPAP. Examine the impact of CPAP withdrawal on sleep, sleep disordered breathing (SDB), and daytime function in subjects with varying severity of OSAHS. Forty-two subjects (26M/16 F) with OSAHS (AHI4% = 45.2 ± ...
Simor Péter - - 2013
Nightmares are disturbing mental experiences during sleep that usually result in abrupt awakenings. Frequent nightmares are associated with poor subjective sleep quality, and recent polysomnographic data suggest that nightmare sufferers exhibit impaired sleep continuity during nonrapid eye movement (NREM) sleep. Because disrupted sleep might be related to abnormal arousal processes, ...
Curie Thomas - - 2013
Besides their well-established role in circadian rhythms, our findings that the forebrain expression of the clock-genes Per2 and Dbp increases and decreases, respectively, in relation to time spent awake suggest they also play a role in the homeostatic aspect of sleep regulation. Here, we determined whether time of day modulates ...
Luo Chunliu - - 2013
We aimed to explore the incidence and persistence of insomnia, the associated risk factors, and the potential bidirectional association of insomnia with depression, anxiety, and sleepiness in rural Chinese adolescents. School-based prospective study. Five high schools in rural China. There were 2,787 adolescents studied. N/A. Insomnia was defined as having ...
Tecle Eillen - - 2013
Heparan sulfate (HS) is an unbranched glycosaminoglycan exhibiting substantial molecular diversity due to multiple, nonuniformly introduced modifications, including sulfations, epimerization, and acetylation. HS modifications serve specific and instructive roles in neuronal development, leading to the hypothesis of a HS code that regulates nervous system patterning. Although the in vivo roles ...
Carlsson Annelie - - 2013
This 26-wk observational study in children and adolescents with type 1 diabetes (T1D) in Sweden investigated the safety and efficacy of insulin detemir (IDet) in newly diagnosed (ND) patients and those with established diabetes (ED) switching to IDet. A total of 159 patients initiated IDet as part of basal-bolus therapy, ...
Lopez Regis R Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, National Reference Network for Narcolepsy, CHU Montpellier, - - 2013
To investigate the restorative quality of sleep and daytime functioning in sleepwalking adult patients in comparison with controls. Prospective case-control study. Data were collected at the Sleep Disorders Center, Hôpital-Gui-de Chauliac, Montpellier, France between June 2007 and January 2011. There were 140 adult sleepwalkers (100 (median age 30 y, 55% ...
Pawl Jean D JD School of Nursing, Georgia State University, Atlanta, GA, USA. - - 2013
To describe the sleep characteristics of family caregivers of individuals with a primary malignant brain tumor (PMBT). Cross-sectional, correlational design using baseline data from a longitudinal study. Neuro-oncology and neurosurgery clinics at an urban tertiary medical center in the United States. 133 family caregivers recruited one to two months following ...
Arnedt J Todd JT Sleep and Chronophysiology Laboratory, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109-2700, USA. - - 2013
To compare the efficacy of telephone-delivered cognitive-behavioral therapy for insomnia to an information pamphlet control on sleep and daytime functioning at pretreatment, posttreatment, and 12-wk follow-up. Randomized controlled parallel trial. N/A. Thirty individuals with chronic insomnia (27 women, age 39.1 ± 14.4 years, insomnia duration 8.7 ± 10.7 years). Cognitive ...
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