Search Results
Results 251 - 300 of 2925
< 1 2 3 4 5 6 7 8 9 10 11 >
García-Rey E - - 2013
Between 1999 and 2001, 90 patients underwent total hip replacement using the same uncemented acetabular and femoral components with a 28 mm metallic femoral head but with prospective randomisation of the acetabular liner to either Durasul highly cross-linked polyethylene or nitrogen-sterilised Sulene polyethylene. We assessed 83 patients at a minimum ...
Stecker Tracy - - 2013
Barriers associated with the decision not to seek treatment for symptoms of combat-related posttraumatic stress disorder (PTSD) were examined. Participants were 143 military men and women who served in Operation Enduring Freedom or Operation Iraqi Freedom (OEF/OIF) and who screened positive for posttraumatic stress disorder (PTSD), as assessed by the ...
Andrews Philip C - - 2013
Reaction of Bi(OtBu)3 with aspirin (acetylsalicylic acid = aspH) in dry toluene results in the bismuth(iii) complex, [Bi(O2C(C6H4)OAc)3]∞ 1 (O2C(C6H4)OAc = asp), minimum inhibitory concentration (MIC) against Helicobacter pylori ≥ 6.25 μg mL-1, while the inclusion of a stoichiometric equivalent of KOtBu leads to crystals of the bismuthate salt [KBi(O2C(C6H4)OAc)4]∞ ...
Matthaei Mario M Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, - - 2013
To investigate the endothelial gene expression profile in a Col8a2 Q455K mutant knock-in mouse model of early-onset Fuchs' endothelial corneal dystrophy (FECD) and identify potential targets that can be correlated to human late-onset FECD. Diseased or normal endothelial phenotypes were verified in 12-month-old homozygous Col8a2(Q455K/Q455K) mutant and wild-type mice by ...
Young Hillary - - 2013
Many studies have suggested that ecosystem conservation protects human and wildlife populations against infectious disease. We tested this hypothesis using data on primates and their parasites. First, we tested for relationships between species' resilience to human disturbance and their parasite richness, prevalence and immune defences, but found no associations. We ...
Lee Junghee J Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, USA. - - 2013
This study aimed to determine the relative extent of impairment in social and nonsocial cognitive domains in patients with bipolar disorder compared with schizophrenia patients and healthy comparison subjects. Sixty-eight clinically stable outpatients with bipolar disorder, 38 clinically stable outpatients with schizophrenia, and 36 healthy comparison subjects completed a range ...
Baptiste Beverly A - - 2013
Dinucleotide microsatellites are dynamic DNA sequences that affect genome stability. Here, we focused on mature microsatellites, defined as pure repeats of lengths above the threshold and unlikely to mutate below it in a single mutational event. We investigated the prevalence and mutational behavior of these sequences by using human genome ...
Chhabra Saurabh - - 2013
Primary adenocarcinomas of the presacral (retrorectal) space are rare. The diagnosis is usually delayed because of non-specific symptoms, and is made after a biopsy or surgery. These carcinomas arise from cystic lesions developing from remnants of the embryological postanal gut containing mucous-secreting epithelium, known as tail gut cysts. The potential ...
Ren Guangwen - - 2013
MicroRNAs regulate cancer metastasis by modulating both the intrinsic properties of tumour cells and their interactions with the tumour stroma. Both strands of the miR-126/miR-126* duplex are now shown to simultaneously target the Sdf-1α cytokine to reduce the recruitment of mesenchymal stem cells and inflammatory monocytes to primary tumours, thereby ...
Leak Ashley - - 2013
To examine demographic and disease characteristics by age and the moderating effect of age on quality of life (QOL) among non-Hodgkin lymphoma (NHL) survivors. A cross-sectional, secondary analysis study of NHL survivors. Two North Carolina cancer registries. 741 NHL survivors with a mean age of 62 years and a mean ...
Gunturu Krishna S - - 2013
Gastric cancer remains difficult to cure and has a poor overall prognosis. Chemotherapy and multimodality therapy has shown some benefit in the treatment of gastric cancer. Current therapies for gastric cancer have their limitations; thus, we are in need of newer treatment options including targeted therapies. Here, we review the ...
Lu Xu - - 2013
Six transcription factors of APETALA2/ethylene-response factor (AP2/ERF) family were cloned and analyzed in Artemisia annua. Real-time quantitative polymerase chain reaction (RT-Q-PCR) showed that AaORA exhibited similar expression patterns to those of amorpha-4,11-diene synthase gene (ADS), cytochrome P450-dependent hydroxylase gene (CYP71AV1) and double bond reductase 2 gene (DBR2) in different tissues ...
Zelle Boris A - - 2013
BACKGROUND:: Loss of follow-up represents a potential source of bias. Suggested guidelines propose 20% loss of follow-up as acceptable. However, these guidelines have not been established through scientific investigations. The goal of this study was to evaluate how loss of follow-up influences the statistical significance in a trauma database. METHODS:: ...
Chun Charlotte A - - 2013
Although neurocognitive deficits are an integral characteristic of schizophrenia, there is inconclusive evidence as to whether they manifest across the schizophrenia-spectrum. We conducted two studies and a meta-analysis comparing neurocognitive functioning between psychometrically defined schizotypy and control groups recruited from a college population. Study One compared groups on measures of ...
Karwalajtys Tina - - 2013
Abstract Purpose. To determine the feasibility of a community-wide approach integrated with primary care (Cardiovascular Health Awareness Program [CHAP]) to promote monitoring of blood pressure (BP) and awareness of cardiovascular disease risk. Design. Demonstration project. Setting. Two midsized Ontario communities. Participants. Community-dwelling seniors. Intervention. CHAP sessions were offered in pharmacies ...
Sam Teena - - 2013
Objective-To review the elements and components of the risk evaluation and mitigation strategies (REMS) for the costimulation blocker belatacept and associated implications for health care providers working with transplant recipients.Data Sources and Extraction-The MEDLINE and EMBASE databases (January 1990 to March 2012) were searched by using risk evaluation and mitigation ...
Parrenin F - - 2013
Understanding the role of atmospheric CO2 during past climate changes requires clear knowledge of how it varies in time relative to temperature. Antarctic ice cores preserve highly resolved records of atmospheric CO2 and Antarctic temperature for the past 800,000 years. Here we propose a revised relative age scale for the ...
Hill Garick - - 2013
Tetralogy of Fallot is the most common cyanotic congenital heart defect. Advances in surgical technique and postoperative care have improved survival which is now very good. Patients now face long-term morbidities such as reduced exercise tolerance and arrthymias. Cardiologists caring for these patients are confronted with decisions regarding best care ...
Melas Philippe A - - 2013
Monoamine oxidase A (MAOA) harbours a polymorphic upstream variable-number tandem repeat (u-VNTR). The MAOA-L allele of the u-VNTR leads to decreased gene expression levels in vitro and has been found to increase the risk of conduct disorder in males with childhood adversities. Early-life adversities have been associated with hypermethylation of ...
Niyadurupola Nuwan - - 2013
There is evidence implicating ischemia and excitotoxicity in the pathogenesis of glaucoma. ATP-mediated excitotoxicity via activation of the P2X7 receptor (P2X7R) has been proposed to play a role in retinal ganglion cell (RGC) degeneration in this disease. The aim of this research was to determine whether stimulation of the P2X7R ...
Lipka Daniel B - - 2013
The patent presents 140 purine and 7-azapurine derivatives as potent inhibitors of DOT1L histone methyltransferase that might be useful in the treatment of leukemia with MLL rearrangements. It is becoming more and more evident that the deregulation of chromatin modifiers such as DOT1L plays a critical role in tumorigenesis. As ...
Vacek Thomas P TP Department of Physiology and Biophysics, University of Louisville School of Medicine Louisville, Louisville, KY 40202, - - 2013
Bone remodeling is a very complex process. Homocysteine (Hcy) is known to modulate this process via several known mechanisms such as increase in osteoclast activity, decrease in osteoblast activity and direct action of Hcy on bone matrix. Evidence from previous studies further support a detrimental effect on bone via decrease ...
Crespel Amélie - - 2013
Discriminating between genetic and environmental causes of phenotypic variation is an essential requirement for understanding the evolutionary potential of populations. However, the extent to which genetic variation differs among conspecific groups and environments during ontogeny has rarely been investigated. In this study, the genetic basis of body mass was measured ...
Iwanir Shachar - - 2013
The nematode C. elegans develops through four larval stages before it reaches adulthood. At the transition between stages and before it sheds its cuticle, it exhibits a sleep-like behavior during a stage termed lethargus. The objectives of this study were to characterize in detail behavioral patterns and physiological activity of ...
Thuesen L L - - 2013
OBJECTIVE: To analyse the endocrine response in relation to the Δ-4 and Δ-5 pathway of ovarian steroidogenesis after different doses of hCG supplementation to recombinant FSH from Day 1 of controlled ovarian stimulation for IVF. DESIGN: A randomised dose-response pilot study. PATIENTS: A total of 62 IVF patients aged 25-37 ...
Cham Kwang M - - 2013
We examined factors influencing perceptual stability in observers with fusion maldevelopment nystagmus syndrome (FMNS). In addition, we also investigated the effect of visual demand, task-related physiologic stress, and motivation on the nystagmus waveform. Perception of oscillopsia during daily activities was assessed via a questionnaire. Perception of oscillopsia in the laboratory ...
Etxebeste Iñaki - - 2013
Some bark beetle species (Coleoptera: Scolytinae) produce aggregation pheromones that allow coordinated attack on their conifer hosts. As a new saproxylic habitat is founded, an assemblage of associated beetles kairomonally respond to bark beetle infochemicals. Ips sexdentatus is one of the major damaging insects of Pinus spp. in Southern Europe. ...
Milligan D J - - 2013
With greater numbers of younger patients undergoing total hip replacement (THR), the effect of patient age on the diameter of the femoral canal may become more relevant. This study aimed to investigate the relationship between the diameter of the diaphysis of the femoral canal with increasing age in a large ...
Casaluce Francesca - - 2013
Mitosis is the key event of the cell cycle, and microtubules play an important part in an array of cellular functions besides mitosis, including maintenance of cell shape, cell locomotion, and the movement of intracellular organelles. Various anti-microtubule agents interfere with normal progression of mitosis, such as taxanes and vinca ...
Song Fengyan - - 2013
A novel chiral ionic polymer exhibits high fluorescence enantioselectivity towards α-amino acid anions, and its solution appears bright green upon addition of (l)-α-amino acid anions, which can be clearly observed by the naked eye for direct visual enantioselective recognition.
Ravuri Chandra - - 2013
Abstract The enzymes γ-glutamyltransferase (GGT) and glutamate cysteine ligase (GCL) have important roles in glutathione (GSH) homeostasis, and both are frequently upregulated after acute oxidative stress. Mitochondria are major producers of ROS, and incubating the colorectal adenocarcinoma cell line HT-29 cells with mitochondrial uncouplers significantly increased both endogenous ROS as ...
Oidtmann B - - 2013
Farmed and wild salmonids are affected by a variety of skin conditions, some of which have significant economic and welfare implications. In many cases, the causes are not well understood, and one example is cold water strawberry disease of rainbow trout, also called red mark syndrome, which has been recorded ...
Pellissier Loïc - - 2013
Understanding drivers of biodiversity patterns is of prime importance in this era of severe environmental crisis. More diverse plant communities have been postulated to represent a larger functional trait-space, more likely to sustain a diverse assembly of herbivore species. Here, we expand this hypothesis to integrate environmental, functional and phylogenetic ...
Haarer Brian - - 2013
The actin cytoskeleton exists in a dynamic equilibrium with monomeric and filamentous states of its subunit protein actin. The spatial and temporal regulation of actin dynamics is critical to the many functions of actin. Actin levels are remarkably constant, suggesting that cells have evolved to function within a narrow range ...
Spoelstra Sandra L - - 2013
To examine whether a history of cancer increased the likelihood of a fall in community-dwelling older adults, and if cancer type, stage, or time since diagnosis increased falls. A longitudinal, retrospective, cohort study. A home- and community-based waiver program in Michigan. 862 older adults aged 65 years or older with ...
Simor Péter - - 2013
Nightmares are disturbing mental experiences during sleep that usually result in abrupt awakenings. Frequent nightmares are associated with poor subjective sleep quality, and recent polysomnographic data suggest that nightmare sufferers exhibit impaired sleep continuity during nonrapid eye movement (NREM) sleep. Because disrupted sleep might be related to abnormal arousal processes, ...
Brown Josephine - - 2013
BACKGROUND: Intramuscular epinephrine (adrenaline) is the first-line therapy for anaphylaxis and prompt administration improves outcome. In 2011, two epinephrine autoinjectors existed in the United Kingdom, differing in their users' administration method: EpiPen® and Anapen® . We routinely train all families who receive these devices. AIM: To evaluate: Maternal competence in ...
Ivankovich Megan B MB Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, GA 30333, - - 2013
Nations across the globe face significant public heath challenges in optimizing sexual health, including reducing human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), sexually transmitted infections (STIs), unintended pregnancies, and sexual violence, and mitigating the associated adverse social and economic impacts. In response, some countries have implemented national strategies and other ...
Szaefer Hanna - - 2013
Red beetroot contains a specific class of antioxidants collectively named betalains, which have been shown to have anticarcinogenic and anti-inflamatory potential. We investigated the effect of beetroot juice on the hepatic and mammary gland carcinogen metabolizing enzymes, DNA damage and liver injury, altered by 7,12-dimethylbenz[a]anthracene (DMBA). In the liver, pretreatment ...
Anselmo Daniele - - 2013
A series of trinuclear, triptycene-based metallosalphen complexes (M = Zn, Ni) have been prepared incorporating various peripheral substituents. The introduction of Zn metal centres into these triptycene based salphen ligands gives rise to cross-linking between different triptycene molecules through μ-phenoxo bridges between the Zn metal centres, and variation in the ...
Raval Jay S - - 2013
Immune thrombocytopenic purpura (ITP) is an autoimmune disease in which IgG-coated platelets are removed from circulation by the spleen, and platelet production is impaired due to increased thrombopoietin (TPO) clearance. Romiplostim, a novel TPO-mimetic agent, is approved for patients with ITP that are unresponsive to traditional treatments. However, there is ...
Hu Kesong - - 2013
Ultra-robust graphene oxide-polymer nanocomposite membranes are presented. The membranes are fabricated by the spin assisted layer-by-layer (SA-LbL) technique and exhibit ultrahigh elastic moduli and outstanding mechanical properties due to complex interactions between the components. A model of the reinforced interphase region is proposed to account for the extraordinary mechanical reinforcement, ...
Sthitmatee Nattawooti - - 2013
The aim of this study was to state that a 39-kDa protein or OmpH of Pasteurella multocida strain P-1059 is essential for cross protection. Strain PBA322, a low capsulated strain of P. multocida strain P-1059, was performed as a live vaccine in chickens. Strain PBA322 is a low capsulated strain ...
Yeniel Ahmet Ö - - 2013
OBJECTIVE: To determine the association between mode of delivery, parity, and pelvic organ prolapse, as assessed by the pelvic organ prolapse quantification system. Design: Cross-sectional study. Setting Tertiary referral center, Turkey. POPULATION: A total of 1964 women with benign gynecological disorders who presented between October 2009 and July 2011. METHODS: ...
Yamashita Takeshi - - 2013
Atrial fibrillation (AF) is becoming an epidemiologically important syndrome among the developed countries. Although racial differences exist with regard to AF prevalence, it remains unclear whether the AF mortality and morbidity rates exhibit racial differences. Medical treatment and management of AF is aimed at improving the clinical course of AF ...
Ganpudi Ashwin L - - 2013
Damaged DNA Binding protein 1 (DDB1)-CULLIN4 E3 ubiquitin ligase complexes have been implicated in diverse biological processes in a range of organisms. encodes two homologs of DDB1, DDB1A, and DDB1B. In this study we use a viable partial loss of function allele of , , to examine genetic interactions with ...
Han Siew-Ping - - 2013
α-catenin exists as part of the cadherin-catenin adhesion complex as well as in a cytoplasmic pool. However, which of these pools is responsible for its biological impact remains controversial. A structure-function analysis in Drosophila melanogaster illuminates how the molecular properties of α-catenin translate into functional outcomes in an intact organism.
Potter Patricia P Patient Care Services, Barnes-Jewish Hospital, USA. - - 2013
To evaluate a resiliency program designed to educate oncology nurses about compassion fatigue. Descriptive pilot study. A National Cancer Institute-designated comprehensive cancer center in the midwestern United States. 13 oncology nurses employed in an outpatient infusion center. Nurses attended a five-week program involving five 90-minute sessions on compassion fatigue resiliency. ...
Peón Antonio - - 2013
Herein we report comparative binding energy (COMBINE) analyses to derive quantitative structure-activity relationship (QSAR) models that help rationalize the determinants of binding affinity for inhibitors of type II dehydroquinase (DHQ2), the third enzyme of the shikimic acid pathway. Independent COMBINE models were derived for Helicobacter pylori and Mycobacterium tuberculosis DHQ2, which ...
Zomorrodi Ali R - - 2013
The ensemble modeling (EM) approach has shown promise in capturing kinetic and regulatory effects in the modeling of metabolic networks. Efficacy of the EM procedure relies on the identification of model parameterizations that adequately describe all observed metabolic phenotypes upon perturbation. In this study we propose an optimization-based algorithm for ...
< 1 2 3 4 5 6 7 8 9 10 11 >