Search Results
Results 201 - 250 of 2912
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Gabardi Steven - - 2013
Objective-To review the history of risk evaluation and mitigation strategies (REMS) with the mammalian target of rapamycin (mToR) inhibitors, evaluate their required REMS elements, and delineate the reasons for them being released from their REMS requirements.Data Sources and Extraction-Articles were identified through a literature search of MEDLINE and EMBASE (January ...
Busch Susan H - - 2013
OBJECTIVES Provisions in the Affordable Care Act (ACA) are likely to expand access to substance use disorder treatment for low-income individuals. The aim of the study was to provide information on the need for substance use disorder treatment among individuals who may be eligible for Medicaid under the ACA. METHODS ...
Zhao Jian - - 2013
Silicone rubber membrane with ordered micropores in the surface was prepared by means of the solvent evaporation-induced phase separation. A ternary solution including liquid silicone rubber precursor, liquid paraffin, and hexane was cast to form a film with a two-phase structure after the hexane was evaporated. The micropores were generated ...
Wacker Sören J - - 2013
Abstract Background: The involvement of aquaporin (AQP) water and small solute channels in the etiology of several diseases, including cancer, neuromyelitis optica and body fluid imbalance disorders, has been suggested previously. Furthermore, results obtained in a mouse model suggested that AQP9 function contributes to hyperglycemia in type-2 diabetes. In addition, ...
Suzanne M - - 2013
Programmed cell death is an important process during development that serves to remove superfluous cells and tissues, such as larval organs during metamorphosis, supernumerary cells during nervous system development, muscle patterning and cardiac morphogenesis. Different kinds of cell death have been observed and were originally classified based on distinct morphological ...
Zimmerman Frederic S - - 2013
Hospitalized carriers of carbapenem-resistant Enterobacteriaceae (CRE) are cohorted under contact precautions, including in the days between rehospitalization and surveillance culture results. This study investigates duration of CRE carriage to define populations requiring precautions upon readmission. Patients with CRE-positive culture during 2009-2010 were followed up by rectal swab cultures taken retrospectively ...
Masjedi M - - 2013
We examined the relationship between the size of the femoral cam in femoroacetabular impingement (FAI) and acetabular pathomorphology to establish if pincer impingement exists in patients with a femoral cam. CT scans of 37 symptomatic impinging hips with a femoral cam were analysed in a three-dimensional study and were compared ...
Young Ryan M - - 2013
Signalling through the B cell receptor (BCR) is central to the development and maintenance of B cells. In light of the numerous proliferative and survival pathways activated downstream of the BCR, it comes as no surprise that malignant B cells would co-opt this receptor to promote their own growth and ...
Arbuckle Melissa R - - 2013
The use of standardized patient assessments (SPAs) in psychiatry is an emerging best practice. This column describes a survey of resident and faculty supervisors at a large academic department examining current practices, attitudes, and perceived barriers to incorporating SPAs into clinical practice. Although the study found that SPAs were not ...
Perlick Deborah A - - 2013
OBJECTIVE This study evaluated the initial efficacy and feasibility of implementing multifamily group treatment for veterans with traumatic brain injury (TBI). METHODS Veterans at two Veterans Affairs medical centers were prescreened by their providers for participation in an open trial of multifamily group treatment for TBI. Enrollment was limited to ...
Correa Rafael - - 2013
BACKGROUND: The HELEX Septal Occluder (HSO) was approved by the Food and Drug Administration for closure of secundum atrial septal defects (ASD) in 2006. However, little mid-term follow-up information is available. The object of this study was to examine mid-term outcomes after HSO implantation METHODS: A retrospective chart review was ...
Chambers Stephanie - - 2013
OBJECTIVES: To assess the validity and reliability of a Parental Dental Concerns Scale (PDCS) to identify parents unable to access preventive dental care for their children. METHODS: Two studies were conducted. In Study One, a purposive convenience sample of 399 Scottish parents answered questions on going to the dentist, family ...
Tseng Wei-Cheng - - 2013
TNFRSF6B overexpression in tumors is a novel predictor for poor prognosis in various cancers; however, whether TNFRSF6B could be expressed in kidney tissues of patients with chronic kidney disease is unknown. Current established risk factors cannot fully predict the progression of chronic kidney disease, and, therefore, it is mandatory to ...
Daalman K - - 2013
BACKGROUND: Several cognitive biases are related to psychotic symptoms, including auditory verbal hallucinations (AVH). It remains unclear whether these biases differ in voice-hearers with and without a 'need-for-care'. Method A total of 72 healthy controls, 72 healthy voice-hearers and 72 clinical voice-hearers were compared on the Cognitive Biases Questionnaire for ...
Shore Jay H - - 2013
The provision of psychiatric treatment via live interactive videoconferencing, frequently termed telepsychiatry, is a viable option for psychiatrists to provide care to individual patients, populations, and communities faced with limited access and to move the point of care delivery into patients' living environments. Psychiatric providers new to videoconferencing should not ...
Nakamura T - - 2013
The aim of this study was to determine whether the level of circulating C-reactive protein (CRP) before treatment predicted overall disease-specific survival and local tumour control in patients with a sarcoma of bone. We retrospectively reviewed 318 patients who presented with a primary sarcoma of bone between 2003 and 2010. ...
Di Fiore David P - - 2013
Approximately 20% of patients undergoing diagnostic angiography for the evaluation of chest pain are found to have a normal coronary angiogram. Although this finding is generally associated with a low risk of cardiac events, approximately half will continue to experience chest pain over the next 12 months. Therefore, the finding ...
Rand Andrew J - - 2013
An elderly patient with watery diarrhea for 3 months received extensive laboratory, radiographic and upper and lower gastrointestinal (GI) endoscopic work up including colonic biopsies, but a diagnosis was not established before death. At autopsy enteropathy associated T-cell lymphoma-type II (EATL-II) with multifocal mucosal involvement of the jejunum was identified. ...
Yu W L - - 2013
Abstract Orbital dermoid cyst is a rare cause of orbital tumor in the adult population. Most of the orbital dermoids are extraconal, arising adjacent to bone suture and occurring in the pediatric patients. Deep orbital dermoid cyst located entirely intraconally is extremely rare. We report a case of intraconal orbital ...
Nathan Paul - - 2013
A number of imaging modalities are showing promise as predictive and prognostic biomarkers in advanced renal cell carcinoma. This review discusses progress to date in this exciting area and identifies areas of future promise.
Efe Cumali - - 2013
Abstract Background. The diagnosis of autoimmune hepatitis (AIH) is already difficult, and that of AIH with chronic viral hepatitis including hepatitis B (HBV) or hepatitis C (HCV) is even more challenging. To date, only a few case-based studies have described this association. Aims. The aim was to retrospectively assess diagnostic ...
Stefanie Babilon - - 2013
Abstract The neuropeptide Y system is known to be involved in the regulation of many central physiological and pathophysiological processes, such as energy homeostasis, obesity, cancer, mood disorders and epilepsy. Four Y receptor subtypes have been cloned from human tissue (hY1, hY2, hY4 and hY5) which form a multiligand/ multireceptor ...
Yamamoto Yui - - 2013
We recently developed a novel cognitive enhancer, ST101 (spiro[imidazo[1,2-a] pyridine-3,2-indan]-2(3H)-one), that activates T-type voltage-gated calcium channels (VGCCs). Here, we address whether T-type VGCC activation with ST101 mediates its cognitive effects in vivo and the relevance of T-type VGCC activation to acetylcholine (ACh) release in the hippocampus. Acute intraperitoneal administration of ...
Lockard Kathleen L - - 2013
A patient with a HeartMate II left ventricular assist device who had a body mass index of 52 needed gastric bypass surgery in order to qualify for a heart transplant. Unlike previous experience in which the surgery was performed at the implant hospital, the gastric bypass surgery in this case ...
de Lacey Sheryl - - 2013
Frozen storage of supernumerary in vitro fertilisation (IVF) embryos benefits patients, but when a decision is required for their disposal this may be experienced as a difficult, emotionally loaded process for many patients. There is the potential at several points for patients to become "stuck" in their decision making and ...
Bruchmann Anja - - 2013
BACKGROUND: The Bag (Bcl-2 associated athanogene) family of proteins consists of 6 members sharing a common, single-copied Bag domain through which they interact with the molecular chaperone Hsp70. Bag5 represents an exception in the Bag family since it consists of 5 Bag domains covering the whole protein. Bag proteins like ...
Habata Yoichi - - 2013
Three tetra-armed cyclens with two kinds of side-arms, 3',5'-difluorobenzyl/4'-methylbenzyl, 3',5'-difluorobenzyl/1'-naphthylmethyl, and 3',5'-difluorobenzyl/9'-anthrylmethyl groups, were prepared by reductive amination of 1,7-bis(3',5'-difluorobenzyl)-1,4,7,10-tetraazacyclododecane and the corresponding aromatic aldehydes in the presence of NaBH(OAc)3. The X-ray structures of the Ag+ complexes and Ag+-ion-induced 1H NMR spectral changes suggest that (i) the chemical shift changes ...
O'Shea Genevieve - - 2013
Ventricular assist devices provide therapeutic options for patients with severe heart failure who have exhausted available medical therapies. With restoration of organ perfusion with ventricular assist devices, the heart failure resolves and quality of life and functional status improve. The current generation of continuous-flow devices present novel challenges to the ...
Clark Lawrence - - 2013
Calcium and strontium metals react with Hg(C6F5)2 and 2,4-di-tert-butylphenol (H-DBP) in tetrahydrofuran (THF) and 1,2-dimethoxyethane (DME) to give [Ca(DBP)2(THF)4] (), [Ca2(DBP)4(DME)4(μ-DME)] (), [Sr3(μ-DBP)6(THF)6] (), and [Sr2(DBP)(μ-DBP)3(DME)3] (). Compound is a six coordinate trans-octahedral monomer, whereas in binuclear two seven-coordinate Ca centres are bridged by a DME ligand. In a central ...
Khanduja V - - 2013
The FRCS (Tr & Orth) examination has three components: MCQs, Vivas and Clinical Examination. The Vivas are further divided into four sections comprising Basic Science, Adult Pathology, Hands and Children's Orthopaedics and Trauma. The Clinical Examination section is divided into Upper and Lower limb cases. The aim of this section ...
Tsui Clement K-M - - 2013
Sexual reproduction in fungi is regulated by the mating-type () locus where recombination is suppressed. We investigated the evolution of loci in eight fungal species belonging to and (Sordariomycetes, Ascomycota) that include conifer pathogens and beetle symbionts. The idiomorph/allele was identified from the assembled and annotated genome, and the locus ...
Gaengel Konstantin - - 2013
Endocytosis has proved to be a versatile mechanism regulating diverse cellular processes, ranging from nutrient uptake to intracellular signal transduction. New work reinforces the importance of endocytosis for VEGF receptor signalling and angiogenesis in the developing eye, and describes a mechanism for its differential regulation in angiogenic versus quiescent endothelial ...
Braga Heitor de - - 2013
BACKGROUND: The use of ethnoecological tools to evaluate possible damage and loss of biodiversity related to the populations of species under some degree of threat may represent a first step towards integrating the political management of natural resources and conservation strategies. From this perspective, this study investigates fishermen's ecological knowledge ...
Genova Maria Luisa - - 2013
Abstract Substantial evidence exists that the mitochondrial respiratory chain is organized in supramolecular units called supercomplexes or respirasomes. While the structural evidence of the supercomplexes is overwhelming, fewer studies were addressed to their functional relevance. Although the presence of Coenzyme Q channelling between Complexes I and III is ascertained, no ...
Crespel Amélie - - 2013
Discriminating between genetic and environmental causes of phenotypic variation is an essential requirement for understanding the evolutionary potential of populations. However, the extent to which genetic variation differs among conspecific groups and environments during ontogeny has rarely been investigated. In this study, the genetic basis of body mass was measured ...
Spence John David - - 2013
Abstract Therapy to lower homocysteine with B vitamins does reduce the risk of stroke, if not myocardial infarction. The apparent lack of efficacy of vitamin therapy in most of the large clinical trials was probably determined by the failure to take account of the metabolic deficiency of vitamin B12, which ...
Foster Patricia L - - 2013
By sequencing the genomes of 34 mutation accumulation lines of a mismatch-repair defective strain of that had undergone a total of 12,750 generations, we identified 1625 spontaneous base-pair substitutions spread across the genome. These mutations are not distributed at random but, instead, fall into a wave-like spatial pattern that is ...
Haspeslagh Annelies - - 2013
Context-Self-management is important in ensuring good clinical results in kidney transplant recipients. It was unclear whether the current education program at a single kidney transplant center sufficiently prepares recent transplant recipients for the many complex self-management tasks required.Objective-To evaluate the completeness of and the satisfaction with the current inpatient kidney ...
Butler Kathleen - - 2013
Abstract Background: Ticagrelor is a direct-acting, reversibly binding, oral P2Y12 platelet inhibitor that reduces thrombotic cardiovascular events in patients with acute coronary syndrome. Dyspnea is one of the most commonly reported adverse events associated with ticagrelor. Objective: To determine the effect of ticagrelor on pulmonary function in healthy elderly volunteers ...
Ye Meidan - - 2013
Hierarchical TiO2 nanotube arrays grown on Ti foil are yielded by subjecting electrochemically anodized, vertically oriented TiO2 nanotube arrays to hydrothermal processing. The resulting DSSCs exhibit a significantly enhanced power conversion efficiency of 7.24%, which is a direct consequence of the synergy of higher dye loading, superior light-scattering ability, and ...
Andreazza Ana C - - 2013
Bipolar disorder (BD) is a chronic psychiatric illness described by severe changes in mood. Extensive research has been carried out to understand the aetiology and pathophysiology of BD. Several hypotheses have been postulated, including alteration in genetic factors, protein expression, calcium signalling, neuropathological alteration, mitochondrial dysfunction and oxidative stress in ...
Boumhras M - - 2013
Mussels may concentrate pollutants, with possibly significant side effects on human health. Therefore, mussels (Mytilus galloprovincialis) from two sites of the Moroccan Atlantic coast (Jorf Lasfar [JL], an industrial site, and Oualidia [OL], a vegetable-growing area), were subjected to biochemical analyses to quantify the presence of heavy metals (Cd, Cr, ...
Yakovlev Vladislav V - - 2013
Optical sensors for ultrasound detection provide high sensitivity and bandwidth, essential for photoacoustic imaging in clinical diagnostics and biomedical research. Implementing plasmonic metamaterials in a non-resonant regime facilitates sub-nanosecond, highly sensitive detectors while eliminating cumbersome optical alignment necessary for resonant sensors.
Mimura Kana - - 2013
Diet therapy is an important treatment component available for obese cats. In this study, the impact of four commercially available prescription diet regimens [1 for general use and 3 aimed at treating obesity and diabetes mellitus (DM)] on short-term post-prandial serum glucose, insulin, triglyceride and non-esterified fatty acid (NEFA) concentrations ...
Haarer Brian - - 2013
The actin cytoskeleton exists in a dynamic equilibrium with monomeric and filamentous states of its subunit protein actin. The spatial and temporal regulation of actin dynamics is critical to the many functions of actin. Actin levels are remarkably constant, suggesting that cells have evolved to function within a narrow range ...
Brown Josephine - - 2013
BACKGROUND: Intramuscular epinephrine (adrenaline) is the first-line therapy for anaphylaxis and prompt administration improves outcome. In 2011, two epinephrine autoinjectors existed in the United Kingdom, differing in their users' administration method: EpiPen® and Anapen® . We routinely train all families who receive these devices. AIM: To evaluate: Maternal competence in ...
Szaefer Hanna - - 2013
Red beetroot contains a specific class of antioxidants collectively named betalains, which have been shown to have anticarcinogenic and anti-inflamatory potential. We investigated the effect of beetroot juice on the hepatic and mammary gland carcinogen metabolizing enzymes, DNA damage and liver injury, altered by 7,12-dimethylbenz[a]anthracene (DMBA). In the liver, pretreatment ...
Anselmo Daniele - - 2013
A series of trinuclear, triptycene-based metallosalphen complexes (M = Zn, Ni) have been prepared incorporating various peripheral substituents. The introduction of Zn metal centres into these triptycene based salphen ligands gives rise to cross-linking between different triptycene molecules through μ-phenoxo bridges between the Zn metal centres, and variation in the ...
Raval Jay S - - 2013
Immune thrombocytopenic purpura (ITP) is an autoimmune disease in which IgG-coated platelets are removed from circulation by the spleen, and platelet production is impaired due to increased thrombopoietin (TPO) clearance. Romiplostim, a novel TPO-mimetic agent, is approved for patients with ITP that are unresponsive to traditional treatments. However, there is ...
Ganpudi Ashwin L - - 2013
Damaged DNA Binding protein 1 (DDB1)-CULLIN4 E3 ubiquitin ligase complexes have been implicated in diverse biological processes in a range of organisms. encodes two homologs of DDB1, DDB1A, and DDB1B. In this study we use a viable partial loss of function allele of , , to examine genetic interactions with ...
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