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Yu Xiaoqiang - - 2013
An efficient method for the synthesis of enaminones is described. The aldol-type addition of ketones to aromatic nitriles proceeded smoothly in the presence of a simple copper catalyst system (CuI-2,2'-bipyridine-NaOtBu) in N,N-dimethylformamide. Enaminones in satisfactory to excellent yields were produced using this technique.
Jiang Xue - - 2013
Using first-principles calculations, we identify a new orthorhombic boron nitride (BN) phase (namely, P-BN; space group: Pmn21), which has similar topological structure to Bct-BN and Z-BN, but without the six-membered ring. This P-BN allotrope is energetically more favorable than previously reported Pnma-BN, Bct-BN and Z-BN phases. With only 0.06 eV/atom less ...
Kim B S - - 2013
We report the incidence and intensity of persistent pain in patients with an otherwise uncomplicated total ankle replacement (TAR). Arthroscopic debridement was performed in selected cases and the clinical outcome was analysed. Among 120 uncomplicated TARs, there was persistent pain with a mean visual analogue scale (VAS) of 2.7 (0 ...
Lu Ellen - - 2013
When contemplating a pregnancy, women treated for multiple sclerosis (MS) with a disease-modifying drug must decide to discontinue their medication before conception or risk exposing their unborn child to potential drug toxicity. Few studies exist as reference for patients and physicians, and of those available, the majority are less than ...
Munn Zachary - - 2013
Assistants have been utilised worldwide in healthcare as a means to ensure the provision of adequate and efficient healthcare in the midst of increased pressures on health services for many years. This review aimed to synthesise available qualitative evidence regarding the appropriateness of strategies used to establish the health assistant ...
Zhu Yue - - 2013
Peritoneal metastasis is a significant clinical challenge; life expectancy following diagnosis is usually very short. Surgical cytoreduction with HIPEC is being used with increasing frequency in selected patients; most outcome data have shown that prolonged median survivals can be observed in selected patients. This review summarizes the published data related ...
Chatterjee Susanta - - 2013
ABSTRACT Purpose: To evaluate the intraocular pressure (IOP) control following combined routes of adjuvant bevacizumab with trabeculectomy in refractory neovascular glaucoma. Methods: From June 2011 to December 2011, 5 consecutive cases of neovascular glaucoma with persistent raised IOP on maximal medical treatment underwent adjuvant bevacizumab by combined routes (subconjunctival (SC) ...
Manuel Jennifer I - - 2013
OBJECTIVE This study explored the range of interventions and the use of more intrusive techniques by staff of assertive community treatment (ACT) teams to promote engagement, manage problem behaviors, and reinforce positive behaviors among patients. Individual and organizational characteristics that may be associated with these practices were identified. METHODS Between ...
Andreou N - - 2013
Aim: To determine whether tonsillectomy improves quality of life in adults suffering from chronic or recurrent tonsillitis. Method: A systematic literature search of the Medline and Pubmed databases was conducted in order to identify all relevant studies measuring quality of life directly. Results and Conclusion: Eight studies were identified. The ...
Ivankovich Megan B MB Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, GA 30333, - - 2013
To identify opportunities within nationally representative surveys and surveillance systems to measure indicators of sexual health, we reviewed and inventoried existing data systems that include variables relevant to sexual health. We searched for U.S. nationally representative surveys and surveillance systems that provided individual-level sexual health data. We assessed the methods ...
Li Ji - - 2013
BACKGROUND: Passive surveillance for congenital anomalies using birth certificates are generally considered to have biased reporting, though the sources of those biases are not well-known nor controlled for. We have analyzed the congenital anomaly reporting data for 418,385 live births in West Virginia (1990-2009) from the 1989 US standard birth ...
Marchesano Valentina - - 2013
Gold nanoparticles have emerged as novel safe and biocompatible tools for manifold applications, including biological imaging, clinical diagnostics and therapeutics. The understanding of the mechanisms governing their interaction with living systems may help the design and development of new platforms for nanomedicine. Here we characterized the dynamics and kinetics of ...
Grunberger G - - 2013
Insulin replacement therapy corrects a core defect of diabetes pathophysiology. Since its introduction as a therapeutic modality almost 100 years ago, insulin therapy has undergone remarkable changes in purity and ability to provide more physiologic control of blood glucose levels. With glucose-lowering potential limited only by risks of hypoglycaemia, which ...
Jackson T L TL King's College London, Department of Opthalmology, King's College Hospital, London, UK. - - 2013
To report the vitreoretinal (VR) surgical case mix in the United Kingdom, the intraoperative complication rate of pars plana vitrectomy (PPV), and the incidence of post-vitrectomy cataract extraction. Participating hospitals prospectively collected ophthalmic data using a single electronic medical record system, with automatic extraction of anonymised data to a national ...
Leonard Tammy T Economics Department, School of Economic, Political and Policy Sciences, University of Texas at Dallas, USA. - - 2013
To examine the relationship between physical activity stages of change and preferences for financial risk and time. A cross-sectional, community-based study. A low-income, urban, African-American neighborhood. One hundred sixty-nine adults. Self-reported physical activity stages of change-precontemplation to maintenance, objectively measured body mass index and waist circumference, and economic preferences for ...
McGillicuddy John W - - 2013
Context-The increasing number of marginal deceased kidney donors and an aging recipient population, prolonged hospitalization, and increased costs have destabilized the economic viability of kidney transplants.Objective-To determine if a delay in the administration of the day-of-discharge dose of rabbit antithymocyte globulin would result in equivalent clinical outcomes with cost savings.Design-Single-center, ...
Vanini Giancarlo G Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109-5615, USA. - - 2013
Gamma-aminobutyric acid (GABA) causes phasic inhibition via synaptic GABAA receptors and tonic inhibition via extrasynaptic GABAA receptors. GABA levels in the extracellular space regulate arousal state and cognition by volume transmission via extrasynaptic GABAA receptors. GABAergic transmission in the pontine reticular formation promotes wakefulness. No previous studies have determined whether ...
Tange Mio - - 2013
The purpose of the study was to evaluate the compatibility of ozagrel sodium solution and calcium-containing transfusions using solubility product constants. We calculated the solubility product constant of mixtures of ozagrel sodium and calcium chloride and evaluated the compatibility of ozagrel sodium solution (both the original and generic products) with ...
Sanchez Juan Antonio - - 2013
Diverse agroecosystems offer phytophagous insects a wide choice of host plants. Myzus persicae is a polyphagous aphid common in moderate climates. During its life cycle it alternates between primary and secondary hosts. A spatial genetic population structure may arise due to environmental factors and reproduction modes. The aim of this ...
Nielsen Hans Linde - - 2013
Abstract Calprotectin (CP) is a calcium-binding cytosolic neutrophil protein and the concentration in feces reflects the migration of neutrophils into the gut lumen. Testing for fecal CP (f-CP) in patients with negative cultures for enteric pathogens is widely accepted as a useful screening tool for identifying patients who are most ...
Soeiro-de-Souza Márcio Gerhardt - - 2013
Bipolar disorder (BD) is a major public health problem characterized by progressive functional impairment. A number of clinical variables have been associated with progression of the disease, most notably number of affective episodes and presence of psychotic symptoms, both of which correlate with greater cognitive impairment, lower response rates for ...
Weiss R R Department of Surgery, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, - - 2013
Interleukin-24 (IL-24), a member of the IL-10 cytokine family whose physiological function remains largely unknown, has been shown to induce apoptosis when expressed in an adenoviral background. It is yet little understood, why IL-24 alone induced apoptosis only in a limited number of tumor cell lines. Analyzing an influenza A ...
Parvathaneni Rajiv K - - 2013
Pearl millet is one of the most important subsistence crops grown in India and sub-Saharan Africa. In many cereal crops, reduced height is a key trait for enhancing yield, and dwarf mutants have been extensively used in breeding to reduce yield loss due to lodging under intense management. In pearl ...
Liu Pan - - 2013
The investigation of a series of oxygen-deficient EuO thin films provided strong evidence that the doped electrons form magnetic polarons with the nearby Eu 4f spins; this is responsible for the enhanced Curie temperature observed near 140 K. Unlike in the previous magnetic polaron models proposed for the metal-to-insulator transition in ...
Kano Taro - - 2013
To develop an instrument to assess the specific symptoms of chemotherapy-induced taste alterations. Cross-sectional study. Two outpatient chemotherapy centers in Kanto, Japan. Convenience sample of 214 adult patients with chemotherapy-induced taste alterations. Items on the chemotherapy-induced taste alteration scale (CiTAS) were developed by a qualitative study of patients with taste ...
Suh Sooyeon - - 2013
This is a population-based longitudinal study that followed insomnia symptoms over a 6-year period in non-depressed individuals. The purpose of the study was to (1) investigate the longitudinal course of depression based on number of insomnia episodes; and (2) describe longitudinal associations between insomnia and depression, and insomnia and suicidal ...
Vallotton Pascal - - 2013
The ability to correctly track objects in time-lapse sequences is important in many applications of microscopy. Individual object motions typically display a level of dynamic regularity reflecting the existence of an underlying physics or biology. Best results are obtained when this local information is exploited. Additionally, if the particle number ...
Xiao Meng - - 2013
A functional device to mimic the beetles of the genus Stenus is fabricated. A superhydrophobic hull is employed to replace the body of the beetles, with an attached reservoir to store low-surface-energy compounds to mimic the beetle's pygidial gland, and a pH-responsive mesh acts as its gland end, whose locomotion ...
Rivi Marco - - 2013
Esterase-based resistance in the peach-potato aphid, Myzus persicae (Sulzer), is generally due to one of two alternative amplified carboxylesterase genes, E4 or FE4 (fast E4). The E4 amplified form is distributed worldwide and it is correlated with a particular translocation between autosomes 1 and 3, whereas the FE4 form, which ...
Stevenson J D - - 2013
Pigmented villonodular synovitis (PVNS) is a rare benign disease of the synovium of joints and tendon sheaths, which may be locally aggressive. We present 18 patients with diffuse-type PVNS of the foot and ankle followed for a mean of 5.1 years (2 to 11.8). There were seven men and 11 ...
Eller Michael - - 2013
Headaches are described as primary, where no contributing cause is found, or secondary, where a discrete lesion or other condition has triggered the phenotype. Primary headache is a common condition; migraine causes much of the morbidity in this population, at great personal and economic cost. The decision to use MRI ...
Chong Lee Moy - - 2013
The aim of the project was to implement the best practice for the maintenance of patency for central venous access devices by registered nurses in an acute ambulatory setting. This project utilised the Joanna Briggs Institute Practical Application of Clinical Evidence System and Getting Research into Practice programs to facilitate ...
Loffeld Ruud J L F - - 2013
Obstruction of the gastrointestinal tract due to cancer can be treated with stenting. The aim was to review the local experience with endoscopic stenting. All patients treated with stenting in a ten years period from 2001-2010 were studied. Fifty one patients received 57 stents because of oesophageal cancer. Mean survival ...
Oren Eyal E University of Washington, Department of Epidemiology, Seattle, WA, USA. - - 2013
Lower socioeconomic status (SES) is associated with increased risk of tuberculosis (TB) and diagnostic delays, but the extent to which this association reflects an underlying gradient in advanced status of pulmonary TB is unknown. We conducted a multilevel retrospective cohort analysis examining the relationship between socioeconomic characteristics and pulmonary TB ...
Carotenuto Marianeve - - 2013
Nm23-H1 is one of the most interesting candidate genes for a relevant role in Neuroblastoma pathogenesis. H-Prune is the most characterized Nm23-H1 binding partner, and its overexpression has been shown in different human cancers. Our study focuses on the role of the Nm23-H1/h-Prune protein complex in Neuroblastoma. Using NMR spectroscopy, ...
Kim Eun Chul - - 2013
ABSTRACT Purpose: To report a case of fungal corneal ulcer and bacterial orbital cellulitis as complications of bacterial endophthalmitis following cataract surgery. Methods: A 51-year-old man underwent anterior chamber irrigation and aspiration in the left eye one day after cataract surgery because of bacterial endophthalmitis. Marked lid swelling with purulent ...
Goswami Shymaprosad - - 2013
For ratiometric "naked eye" detection of CN-, an ESIPT exhibiting benzothiazole receptor (BHI) is designed having one aldehyde group ortho and the other aldehyde para to the OH group respectively. Due to RAHBs, the ortho aldehyde group is highly reactive undergoing nucleophilic cyanide addition selectively, which hampered ESIPT. This is ...
Pan Changduo - - 2013
A palladium-catalyzed decarboxylative C2-acylation of indoles with α-oxocarboxylic acids was achieved. This protocol represents a novel and complementary approach to 2-aroylindoles.
Lanza Amanda M - - 2013
Selection markers are common genetic elements used in recombinant cell line development. While several selection systems exist for use in mammalian cell lines, no previous study has comprehensively evaluated their performance in the isolation of recombinant populations and cell lines. Here we examine four antibiotics, hygromycin, neomycin, puromycin, and Zeocin, ...
Karpova Alina - - 2013
STUDY DESIGN.: Prospective study. OBJECTIVE.: To determine whether magnetic resonance imaging and clinical and demographic findings in patients with cervical spondylotic myelopathy (CSM) were independently associated with baseline functional scores and whether these were also predictive of postoperative functional outcomes. SUMMARY OF BACKGROUND DATA.: There are considerable limitations in current ...
Fabietti Alessandra - - 2013
This study reports the first extensive shotgun analysis of the Bartonella quintana proteome. Proteins extracted from two Bartonella quintana strains, Oklahoma and JK31, were analyzed in triplicate analyses by a bottom-up approach consisting of tryptic digestion in SDS-containing buffer, strong cation-exchange StageTip fractionation and nano-LC-MS/MS analysis. By setting spectral false discovery ...
Allhenn Daniela - - 2013
For the treatment of glioblastoma multiforme, an "anticancer drug cocktail" delivered by biodegradable poly-lactide-co-glycolide (PLGA)-microspheres is proposed. Celecoxib, etoposide, and elacridar were encapsulated by an oil/water emulsification solvent evaporation method. Drug-loaded microspheres were analyzed for their physicochemical properties and evaluated in a rat glioblastoma model. Microspheres had a mean diameter ...
Zhou Y - - 2013
Malignant ascites is common in various types of cancers and is difficult to manage. Vascular endothelial growth factor (VEGF) has a pivotal role in malignant ascites. The matrix protein of vesicular stomatitis virus (VSVMP) has been shown to inhibit host gene expression and induce the apoptosis of cancer cells. The ...
Alge Daniel L - - 2013
The implementation of bio-orthogonal click chemistries is a topic of growing importance in the field of biomaterials, as it is enabling the development of increasingly complex hydrogel materials capable of providing dynamic, cell-instructive microenvironments. Here, we introduce the tetrazine-norbornene inverse electron demand Diels-Alder reaction as a new crosslinking chemistry for ...
Jack C M - - 2013
The practice of removing a well-fixed cementless femoral component is associated with high morbidity. Ceramic bearing couples are low wearing and their use minimises the risk of subsequent further revision due to the production of wear debris. A total of 165 revision hip replacements were performed, in which a polyethylene-lined ...
Di Minno Matteo Nicola Dario - - 2013
The usefulness of anticoagulation in patients with atrial fibrillation (AF) is well known. However, the inherent limitations of vitamin K antagonists (VKAs) have made the development of new oral anticoagulants necessary. Drugs directed against thrombin or the factor Xa are currently available. These molecules, being administered at fixed doses and ...
Vogt Kristy L - - 2013
The authors highlight a report of an American Dental Association Laboratory analysis of latex examination gloves that appears in Volume 8, Issue 1 of the online ADA Professional Product Review and present results of a pilot study of the watertightness of powder-free natural rubber latex examination gloves.
Yang Lawrence H LH Department of Epidemiology, Columbia University, New York, NY 10032, USA. - - 2013
This study compared stigma associated with the psychosis risk label and diagnostic labels for nonpsychotic and psychotic mental disorders among young adult peers. Urban college respondents (N=153) read an experimental vignette describing a young adult experiencing prodromal symptoms who was randomly assigned a diagnostic label (major depression, generalized anxiety disorder, ...
Yang Huan - - 2013
An unprecedented 3-D SHG-active metal-organic framework (MOF) of silver(i), Ag-Amidn () (HAmidn: 2-amino-4,5-imidazoledicarbonitrile), has been successfully prepared by employing the new single ligand. The cooperative coordination of the imidazole and carbonitrile N atoms leads to the chiral triple helices accounting for the noncentrosymmetric space group, which are linked together to ...
Okmen Bilal - - 2013
α-Tomatine is an antifungal glycoalkaloid that provides basal defense to tomato (Solanum lycopersicum). However, tomato pathogens overcome this basal defense barrier by the secretion of tomatinases that degrade α-tomatine into the less fungitoxic compounds β-tomatine and tomatidine. Although pathogenic on tomato, it has been reported that the biotrophic fungus Cladosporium ...
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