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Magnusson Lina L Department of Rehabilitation, School of Health Sciences, Jönköping University and Swedish Institute for Disability Research, P.O. Box 1026, SE-551 11 Jönköping, Sweden. - - 2013
To investigate patients' mobility and satisfaction with their lower limb prosthetic or orthotic device and related service delivery in Malawi and to compare groups of patients regarding type and level of device and demographics. Questionnaires were used to collect self-report data from 83 patients. Ninety percent of prostheses or orthoses ...
Lisboa Renato R Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, CA 92093, - - 2013
It is reasonable to hypothesize that for 2 patients with similar degrees of integrated binocular visual field (BVF) loss, the patient with a history of faster disease progression will report worse vision-related quality of life (VRQOL) than the patient with slowly progressing damage. However, to our knowledge, this hypothesis has ...
Elbers Roy G RG University of Applied Sciences Leiden, P.O. BOX 382, 2300 AJ Leiden, The Netherlands. - - 2013
To investigate the predictive value of gait speed for community walking in Parkinson's disease and to develop a multivariate prediction model for community walking. Data from baseline assessments in a randomized clinical trial were used. A total of 153 patients with Parkinson's disease were included. Community walking was evaluated using ...
Law Sean M SM Department of Chemistry and Biophysics Program, University of Michigan, Ann Arbor, Michigan 48109, - - 2013
Tombusviruses, such as Carnation Italian ringspot virus (CIRV), encode a protein homodimer called p19 that is capable of suppressing RNA silencing in their infected hosts by binding to and sequestering short-interfering RNA (siRNA) away from the RNA silencing pathway. P19 binding stability has been shown to be sensitive to changes ...
Toal Siobhan S Department of Chemistry, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, - - 2013
Several lines of evidence now well establish that unfolded peptides in general, and alanine in specific, have an intrinsic preference for the polyproline II (pPII) conformation. Investigation of local order in the unfolded state is, however, complicated by experimental limitations and the inherent dynamics of the system, which has in ...
Gambino Valentina - - 2013
Oxidative stress is a determining factor of cellular senescence and aging and a potent inducer of the tumour-suppressor p53. Resistance to oxidative stress correlates with delayed aging in mammals, in the absence of accelerated tumorigenesis, suggesting inactivation of selected p53-downstream pathways. We investigated p53 regulation in mice carrying deletion of ...
Jiang Xiang-Rong XR Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, United - - 2013
Estrogen receptor (ER) antagonists are valuable in the treatment of ER-positive human breast cancer. In this study, we designed and synthesized nine new derivatives of 17β-estradiol (E2) with a bulky side chain attached to its C-7α position, and determined their ER antagonistic activity using in vitro bioassays. Four of the ...
Baghy Kornélia K 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, - - 2013
Decorin, a secreted small leucine-rich proteoglycan, acts as a tumor repressor in a variety of cancers, mainly by blocking the action of several receptor tyrosine kinases such as the receptors for hepatocyte, epidermal and insulin-like growth factors. In the present study we investigated the effects of decorin in an experimental ...
Aguilar Angelo A Comprehensive Cancer Center and Department of Internal Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, Michigan 48109-0934, United - - 2013
Our previously reported Bcl-2/Bcl-xL inhibitor, 4, effectively inhibited tumor growth but failed to achieve complete regression in vivo. We have now performed extensive modifications on its pyrrole core structure, which has culminated in the discovery of 32 (BM-1074). Compound 32 binds to Bcl-2 and Bcl-xL proteins with K(i) values of ...
Patel Ashay A Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1234, - - 2013
A novel stereoselective electrocyclization developed for the total synthesis of reserpine has been explored by both experiment and theory. A stereocenter six atoms away from the newly forming chiral center is responsible for the diastereoselectivity of the ring closure. This stereogenic center, lying at the junction of two six-membered rings, ...
Horne Alexandra J AJ Department of Biological Sciences, University of Arkansas-Fayetteville, Fayetteville, AR, - - 2013
All methane-producing Archaea (methanogens) are strict anaerobes, but the majority of species are tolerant to oxidants. Methanosarcina species are important environmental and industrial methanogens as they are one of only two genera capable of producing methane with acetate. Importantly, Methanosarcina species appear to be the most oxidant-tolerant; however, the mechanisms ...
Zhang Fuming F Departments of Chemical and Biological Engineering, Chemistry and Chemical Biology, Biology, and Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute , Troy, New York 12180, United - - 2013
CrataBL, a protein isolated from Crataeva tapia bark, which is both a serine protease inhibitor and a lectin, has been previously shown to exhibit a number of interesting biological properties, including anti-inflammatory, analgesic, antitumor, and insecticidal activities. Using a glycan array, we have now shown that only sulfated carbohydrates are ...
Kiyatkin Eugene A EA In-Vivo Electrophysiology Unit, Behavioral Neuroscience Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health/DHHS, 333 Cassell Drive, Baltimore, MD 21224, United States. - - 2013
The rate of any chemical reaction or process occurring in the brain depends on temperature. While it is commonly believed that brain temperature is a stable, tightly regulated homeostatic parameter, it fluctuates within 1-4 °C following exposure to salient arousing stimuli and neuroactive drugs, and during different behaviors. These temperature ...
Andriani Grasiella G Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, - - 2013
Chagas disease is caused by the intracellular protozoan parasite Trypanosomal cruzi , and current drugs are lacking in terms of desired safety and efficacy profiles. Following on a recently reported high-throughput screening campaign, we have explored initial structure-activity relationships around a class of imidazole-based compounds. This profiling has uncovered compounds ...
Zhu Xiang - - 2013
A porous, nitrogen-doped carbonaceous free-standing membrane (TFMT-550) is prepared by a facile template-free method using letrozole as an intermediate to a triazole-functionalized-triazine framework, followed by carbonization. Such adsorption/diffusion membranes exhibit good separation performance of CO over N and surpassing the most recent Robeson upper bound. An exceptional ideal CO /N ...
Liu Simin S Department of Chemistry, Tulane University, New Orleans, Louisiana 70115, - - 2013
Two hosts that utilize the hydrophobic effect to assemble and/or encapsulate guest molecules were studied. The hosts, octa-acid (OA) and hexalene diamine-linked octa-acid (HOA), were shown to complex a broad range of n-alkanes up to n-hexacosane (C26H54). A combination of (1)H NMR, NMR diffusion, COSY, and NOESY experiments revealed four ...
Glattacker Manuela M Department of Quality Management and Social Medicine, University Freiburg - Medical Center, Freiburg, Germany. - - 2013
Patients' illness beliefs were shown to be more relevant than other psychosocial factors of influence for predicting outcome in back pain in primary care. The aim of this study was to determine whether illness beliefs and beliefs about rehabilitation are predictors of functioning, pain intensity, and coping with pain after ...
Holmes David R DR - - 2013
The management of complex cardiovascular disease has changed markedly with the development of new strategies of care, an increasing amount of scientific evidence-based data and appropriate use criteria. Applying this plethora of information and synthesizing it for presentation and recommendations to the patient and family have assumed central importance. To ...
Rekhraj Sushma - - 2013
This study sought to ascertain if high-dose allopurinol regresses left ventricular mass (LVM) in patients with ischemic heart disease (IHD). LV hypertrophy (LVH) is common in patients with IHD including normotensive patients. Allopurinol, a xanthine oxidase inhibitor, has been shown to reduce LV afterload in IHD and may therefore also ...
Jilaihawi Hasan - - 2013
This study compared cross-sectional three-dimensional (3D) transesophageal echocardiography (TEE) to two-dimensional (2D) TEE as methods for predicting aortic regurgitation after transcatheter aortic valve replacement (TAVR). Data have shown that TAVR sizing using cross-sectional contrast computed tomography (CT) parameters is superior to 2D-TEE for the prediction of paravalvular aortic regurgitation (AR). ...
Kutyifa Valentina - - 2013
The aim of this study was to evaluate the relationship between left ventricular (LV) ejection fraction and clinical outcome to cardiac resynchronization therapy (CRT) in mild heart failure patients enrolled in MADIT-CRT [corrected]. Left ventricular ejection fraction (LVEF) is a surrogate marker of heart failure (HF) status and associated risk. ...
Habib Anwer A Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA 30322, - - 2013
This study sought to examine the effect of oral metformin (Mf) therapy on endothelialization in the setting of drug-eluting stents (DES). Mf is a commonly used therapy in diabetic patients receiving DES. Mf and locally eluted mammalian target of rapamycin (mTOR) inhibitors used in DES have convergent molecular signaling; however, ...
Gampe Christian M CM Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, - - 2013
New antibiotic drugs need to be identified to address rapidly developing resistance of bacterial pathogens to common antibiotics. The natural antibiotic moenomycin A is the prototype for compounds that bind to bacterial peptidoglycan glycosyltransferases (PGTs) and inhibit cell wall biosynthesis, but it cannot be used as a drug. Here we ...
Metcalfe A J - - 2013
The aim of this study was to examine the loading of the other joints of the lower limb in patients with unilateral osteoarthritis (OA) of the knee. We recruited 20 patients with no other symptoms or deformity in the lower limbs from a consecutive cohort of patients awaiting knee replacement. ...
Bandi Venugopal - - 2013
A novel broad-band capturing and emitting supramolecular triad useful for solar energy harvesting and building optoelectronic devices is reported.
Liu Xiaoran - - 2013
Background: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD), with > 44% of these patients presenting with generalized atherosclerosis at autopsy. It is accepted that endothelial progenitor cells (EPCs) participate in the repair of dysfunctional endothelium, thereby, protecting ...
Tojo Shinjiro - - 2013
STUDY DESIGN.: A retrospective, consecutive case series. OBJECTIVE.: To analyze the relationship between retro-odontoid soft-tissue thickness and patients' age, sex, and degenerative changes of cervical spine and to investigate the effect these factors have on retro-odontoid soft-tissue thickness. SUMMARY OF BACKGROUND DATA.: Thickening of the soft tissue posterior to the ...
Hannedouche Jérôme - - 2013
Asymmetric hydroamination allows the direct and selective formation of a new CN bond as a simple procedure towards valuable scalemic synthons. Huge efforts have recently been made to overcome the challenges associated with this transformation. This non-comprehensive Concept article aims at pointing out the most recent and original progresses, offering ...
Schönwald Liane I - - 2013
In our previous studies on competition for attentional processing resources in early visual cortex between a foreground task and distracting emotional background images we found that emotional background images withdraw attentional resources from the foreground task after about 400 ms. Costs in behavioral data and a significant reduction of the ...
Lu M-Y - - 2013
BACKGROUND: The aims of our study were to evaluate (i) the relationship between cardiac T2* values and cardiac complications in Asian β-thalassaemia major (TM) patients, and (ii) the association between cardiac T2* values and other parameters currently used to predict cardiac complications as a result of transfusion iron overload. METHODS: ...
Clement N D - - 2013
We assessed the effect of mental disability on the outcome of total knee replacement (TKR) and investigated whether mental health improves post-operatively. Outcome data were prospectively recorded over a three-year period for 962 patients undergoing primary TKR for osteoarthritis. Pre-operative and one year Short-Form (SF)-12 scores and Oxford knee scores ...
Cumurcu Tongabay - - 2013
Abstract A 65-year-old female patient presented with eye pain, swelling and blurred vision in the left eye. Routine biochemistry and microbiological analyzes were conducted. Orbital tomography (CT), magnetic resonance imaging (MRI) findings, and cerebral angiography were performed. Orbital cellulitis due to a complication of ethmoidal sinusitis was diagnosed with thrombosis ...
Yu Xiaoqiang - - 2013
An efficient method for the synthesis of enaminones is described. The aldol-type addition of ketones to aromatic nitriles proceeded smoothly in the presence of a simple copper catalyst system (CuI-2,2'-bipyridine-NaOtBu) in N,N-dimethylformamide. Enaminones in satisfactory to excellent yields were produced using this technique.
Jiang Xue - - 2013
Using first-principles calculations, we identify a new orthorhombic boron nitride (BN) phase (namely, P-BN; space group: Pmn21), which has similar topological structure to Bct-BN and Z-BN, but without the six-membered ring. This P-BN allotrope is energetically more favorable than previously reported Pnma-BN, Bct-BN and Z-BN phases. With only 0.06 eV/atom less ...
Farrell Christopher-John L - - 2013
Abstract Folate deficiency has been linked to diverse clinical manifestations and despite the importance of accurate assessment of folate status, the best test for routine use is uncertain. Both serum and red cell folate assays are widely available in clinical laboratories; however, red cell folate is the more time-consuming and ...
Fernandez Sthefanie - - 2013
The bullfrog (Lithobates catesbeianus) is an exotic animal that adapted perfectly to the climatic conditions of Brazil after introduction in the country. These climatic conditions favor the reproduction and fattening of bullfrogs. However, the development of the bullfrog is significantly reduced in colder regions because low temperatures affect the secretion ...
Smaill Bruce H - - 2013
Impulse propagation in the heart depends on the excitability of individual cardiomyocytes, impulse transmission between adjacent myocytes, and the 3-dimensional arrangement of those cells. Here, we review the role of each of these factors in normal and aberrant cardiac electric activation, with particular emphasis on the effects of 3-dimensional myocyte ...
Raymann Kasie - - 2013
Bacteria and eukaryotes are involved in many types of interaction in nature, with important ecological consequences. However, the diversity, occurrence, and mechanisms of these interactions often are not fully known. The obligate bacterial endosymbionts of Paramecium provide their hosts with the ability to kill sensitive Paramecium strains through the production ...
Carroll D - - 2013
ACCESSIBLE SUMMARY: The findings from this study reveal that the notion of anticipated and deleterious differences in quality of life (QoL) between children with severe emotional and behavioural problems and those without such difficulties is not supported. Indeed, results reveal counter-intuitive findings with children with emotional and behavioural problems reporting ...
Cho Kyung Jin - - 2013
Three tetranuclear clusters [(TpMe,mt3)Fe(CN)3Mn(L)]2 (, L = 5-Clacphmen; , L = 5-Clsalen; , L = 5-MeOsalen; TpMe,mt3 = hydrotris(3-methyl-4,5-propylene-5-methylpyrazol-1-yl)borate) were prepared by assembling the fac-Fe tricyanide with the corresponding Mn Schiff bases. The assembled molecules are linked by cyanide and phenoxide bridges. Weak π-π contacts between molecules are evident in ...
Ikpo Nduka - - 2013
Al complexes are widely used in a range of polymerization reactions (ROP of cyclic esters and cationic polymerization of alkenes). Since the discovery in 1978 that an Al porphyrin complex could copolymerize propylene oxide with carbon dioxide, Al coordination compounds have been studied extensively as catalysts for epoxide-carbon dioxide copolymerizations. ...
Katsenis Dimitris - - 2013
OBJECTIVES:: To evaluate the treatment alternatives for the management of the metaphyseal tibial comminution in severe plafond fractures, and to investigate the role of the fibula fracture fixation. DESIGN:: Retrospective clinical study. SETTING:: Level-2 trauma hospital. PARTICIPANTS:: Patients with highly comminuted tibial plafond fractures. INTERVENTION:: All patients were treated with ...
Willner Dana - - 2013
Culture-independent high-throughput sequencing has provided unprecedented insights into microbial ecology, particularly for Earth's most ubiquitous and diverse inhabitants - the viruses. A plethora of methods now exist for amplifying the vanishingly small amounts of nucleic acids in natural viral communities in order to sequence them, and sequencing depth is now ...
Claßen-Bockhoff Regine - - 2013
BACKGROUND: Genes encoding TCP transcription factors, such as CYCLOIDEA-like (CYC-like) genes, are well known actors in the control of plant morphological development, particularly regarding the control of floral symmetry. Despite recent understanding that these genes play a role in establishing the architecture of inflorescences in the sunflower family (Asteraceae), where ...
Kugan R - - 2013
Achieving arthrodesis of the ankle can be difficult in the presence of infection, deformity, poor soft tissues and bone loss. We present a series of 48 patients with complex ankle pathology, treated with the Ilizarov technique. Infection was present in 30 patients and 30 had significant deformity before surgery. Outcome was ...
Levine Steven M - - 2013
Evaluation of: Al-Radaideh AM, Wharton SJ, Lim SY et al. Increased iron accumulation occurs in the earliest stages of demyelinating disease: an ultra-high field susceptibility mapping study in clinically isolated syndrome. Mult. Scler. doi:10.1177/1352458512465135 (2012) (Epub ahead of print). Iron has been shown to accumulate in deep gray matter structures ...
Zhong Jim - - 2013
Ampulla of Vater carcinomas are rare malignancies that have been traditionally treated with radical surgical resection. Given the mortality associated with pancreaticoduodenectomy, some patients may benefit from local resection. A single-institution outcomes analysis was performed to define the role of local resection. Patients undergoing local resection (ampullectomy) for ampullary carcinomas ...
Kim Eun Chul - - 2013
ABSTRACT Purpose: To report a case of complete occlusion of the capsulorhexis opening in a DM patient with high hemoglobin A1C level. Methods: A 77-year-old woman with non-insulin-dependent diabetes underwent uncomplicated phacoemulsification in both eyes. One year later, she presented again because of reduced vision (best-corrected visual acuity of 16/20 ...
Lewis Richard A - - 2013
Oxidation of [Li(THF)]2[Co(N[double bond, length as m-dash]CtBu2)4] with 1 equiv. of I2 generates Co(N[double bond, length as m-dash]CtBu2)4 in 85% yield. In the solid-state, this complex exhibits a squashed tetrahedral structure about the Co center. DFT calculations reveal this geometry arises, in part, to maximize ketimide-to-cobalt π-donation.
Gören Jessica L - - 2013
OBJECTIVE To ensure optimal care for patients with schizophrenia, antipsychotic medications must be appropriately prescribed and used. Therefore, the primary objectives of this study were to identify and describe pathways for antipsychotic prescribing, assess the consistency of observed pathways with treatment guidelines, and describe variability across facilities. METHODS Data from ...
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