Search Results
Results 451 - 500 of 2912
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Young Laura R - - 2013
Patients with obstructive sleep apnea/hypopnea syndrome (OSAHS), even those generally compliant with CPAP therapy, often intermittently discontinue CPAP. Examine the impact of CPAP withdrawal on sleep, sleep disordered breathing (SDB), and daytime function in subjects with varying severity of OSAHS. Forty-two subjects (26M/16 F) with OSAHS (AHI4% = 45.2 ± ...
Simor Péter - - 2013
Nightmares are disturbing mental experiences during sleep that usually result in abrupt awakenings. Frequent nightmares are associated with poor subjective sleep quality, and recent polysomnographic data suggest that nightmare sufferers exhibit impaired sleep continuity during nonrapid eye movement (NREM) sleep. Because disrupted sleep might be related to abnormal arousal processes, ...
Curie Thomas - - 2013
Besides their well-established role in circadian rhythms, our findings that the forebrain expression of the clock-genes Per2 and Dbp increases and decreases, respectively, in relation to time spent awake suggest they also play a role in the homeostatic aspect of sleep regulation. Here, we determined whether time of day modulates ...
Luo Chunliu - - 2013
We aimed to explore the incidence and persistence of insomnia, the associated risk factors, and the potential bidirectional association of insomnia with depression, anxiety, and sleepiness in rural Chinese adolescents. School-based prospective study. Five high schools in rural China. There were 2,787 adolescents studied. N/A. Insomnia was defined as having ...
Vanini Giancarlo - - 2013
Gamma-aminobutyric acid (GABA) causes phasic inhibition via synaptic GABAA receptors and tonic inhibition via extrasynaptic GABAA receptors. GABA levels in the extracellular space regulate arousal state and cognition by volume transmission via extrasynaptic GABAA receptors. GABAergic transmission in the pontine reticular formation promotes wakefulness. No previous studies have determined whether ...
Herbst David Alan DA - - 2013
Chronic hepatitis C virus (HCV) infection is ubiquitous, affecting approximately 180 million individuals worldwide and around 3.2 million in the United States. While peginterferon and ribavirin alone continue to be used, the treatment landscape for patients with genotype 1 has recently changed to include one of two protease inhibitors: boceprevir ...
Qiu Penghe - - 2013
A novel scaffold composed of loosely branched hollow silica microfibers that has been proven to be highly biocompatible is proposed for the 3D culture of cancer cells. The MCF-7 cancer cells can grow and proliferate freely inside the scaffold in the form of multicellular spheroids. MCF-7 cancer cells cultured on ...
Tecle Eillen - - 2013
Heparan sulfate (HS) is an unbranched glycosaminoglycan exhibiting substantial molecular diversity due to multiple, nonuniformly introduced modifications, including sulfations, epimerization, and acetylation. HS modifications serve specific and instructive roles in neuronal development, leading to the hypothesis of a HS code that regulates nervous system patterning. Although the in vivo roles ...
Carlsson Annelie - - 2013
This 26-wk observational study in children and adolescents with type 1 diabetes (T1D) in Sweden investigated the safety and efficacy of insulin detemir (IDet) in newly diagnosed (ND) patients and those with established diabetes (ED) switching to IDet. A total of 159 patients initiated IDet as part of basal-bolus therapy, ...
Lopez Regis R Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, National Reference Network for Narcolepsy, CHU Montpellier, - - 2013
To investigate the restorative quality of sleep and daytime functioning in sleepwalking adult patients in comparison with controls. Prospective case-control study. Data were collected at the Sleep Disorders Center, Hôpital-Gui-de Chauliac, Montpellier, France between June 2007 and January 2011. There were 140 adult sleepwalkers (100 (median age 30 y, 55% ...
Lee Junghee J Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, USA. - - 2013
This study aimed to determine the relative extent of impairment in social and nonsocial cognitive domains in patients with bipolar disorder compared with schizophrenia patients and healthy comparison subjects. Sixty-eight clinically stable outpatients with bipolar disorder, 38 clinically stable outpatients with schizophrenia, and 36 healthy comparison subjects completed a range ...
Pawl Jean D JD School of Nursing, Georgia State University, Atlanta, GA, USA. - - 2013
To describe the sleep characteristics of family caregivers of individuals with a primary malignant brain tumor (PMBT). Cross-sectional, correlational design using baseline data from a longitudinal study. Neuro-oncology and neurosurgery clinics at an urban tertiary medical center in the United States. 133 family caregivers recruited one to two months following ...
Arnedt J Todd JT Sleep and Chronophysiology Laboratory, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109-2700, USA. - - 2013
To compare the efficacy of telephone-delivered cognitive-behavioral therapy for insomnia to an information pamphlet control on sleep and daytime functioning at pretreatment, posttreatment, and 12-wk follow-up. Randomized controlled parallel trial. N/A. Thirty individuals with chronic insomnia (27 women, age 39.1 ± 14.4 years, insomnia duration 8.7 ± 10.7 years). Cognitive ...
Tingen Martha S MS Child Health Discovery Institute, Georgia Prevention Institute, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA. - - 2013
This study evaluated similarities and differences of enrollment rates using two different recruitment strategies for a tobacco control trial in rural and urban African-American (AA) elementary school families. A comparative study, nested within a larger randomized controlled trial, was used to test the effectiveness of two recruitment approaches on enrollment ...
Scheiermann Patrick - - 2013
Multidrug-resistant Gram-negative induced sepsis poses an increasing threat to the vulnerable intensive care patient. The study by Toufekoula and colleagues reports the serum and tissue concentration of malondialdehyde (MDA), the toxic end product of lipid peroxidation, during the course of experimental and human Gram-negative sepsis. The complementary results from this ...
MacDonald Michael R Bob MR Navy and Marine Corps Public Health Center, Sexual Health and Responsibility Program, Portsmouth, VA 23708, USA. - - 2013
In 1999, the Navy and Marine Corps Public Health Center converted an HIV train-the-trainer program into a broader effort of preventing not just HIV, but also other sexually transmitted infections (STIs) and unplanned pregnancies. The premise for this broader approach was that a more comprehensive sexual health promotion message of ...
Sutton Jonathan T JT University of Cincinnati, College of Medicine, Internal Medicine, Division of Cardiovascular Diseases, and Biomedical Engineering Program, Cincinnati, OH, - - 2013
Ultrasound (US) has been developed as both a valuable diagnostic tool and a potent promoter of beneficial tissue bioeffects for the treatment of cardiovascular disease. These effects can be mediated by mechanical oscillations of circulating microbubbles, or US contrast agents, which may also encapsulate and shield a therapeutic agent in ...
White Stuart F SF National Institute of Mental Health, Bethesda, MD, USA. - - 2013
Youths with disruptive behavior disorders, including conduct disorder and oppositional defiant disorder, show major impairments in reinforcement-based decision making. However, the neural basis of these difficulties remains poorly understood. This partly reflects previous failures to differentiate responses during decision making and feedback processing and to take advantage of computational model-based ...
Pandit Sandeep V SV Center for Arrhythmia Research, University of Michigan, NCRC, 2800 Plymouth Rd, Ann Arbor, MI 48109, - - 2013
The objective of this article is to present a broad review of the role of cardiac electric rotors and their accompanying spiral waves in the mechanism of cardiac fibrillation. At the outset, we present a brief historical overview regarding reentry and then discuss the basic concepts and terminologies pertaining to ...
Yang Lawrence H LH Department of Epidemiology, Columbia University, New York, NY 10032, USA. - - 2013
This study compared stigma associated with the psychosis risk label and diagnostic labels for nonpsychotic and psychotic mental disorders among young adult peers. Urban college respondents (N=153) read an experimental vignette describing a young adult experiencing prodromal symptoms who was randomly assigned a diagnostic label (major depression, generalized anxiety disorder, ...
Bertolli Jeanne J Centers for Disease Control and Prevention, Division of HIV/AIDS Prevention, Atlanta, GA 30333, USA. - - 2013
Clinical interventions that lengthen life after HIV infection and significantly reduce transmission could have greater impact if more HIV-diagnosed people received HIV care. We tested a surveillance-based approach to investigating reasons for delayed entry to care. Health department staff in three states and two cities contacted eligible adults diagnosed with ...
Penman-Aguilar Ana A Centers for Disease Control and Prevention, Office of Minority Health and Health Equity, Atlanta, GA 30333, USA. - - 2013
We reviewed the literature focused on socioeconomic influences on teen childbearing and suggested directions for future research and practice related to this important indicator of teen sexual health. We conducted an electronic search of Medline, ERIC, PsychLit, and Sociological Abstracts databases for articles published from January 1995 to November 2011. ...
Murray Colleen Crittenden CC Emory University, Rollins School of Public Health, Atlanta, GA 30322, USA. - - 2013
We assessed young African American women's understanding of "dual protection" (DP) (i.e., strategies that simultaneously protect against unintended pregnancies and sexually transmitted diseases [STDs]) and how relationship factors influence their use of DP methods. We conducted 10 focus groups with African American women (n=51) aged 15-24 years in Atlanta, Georgia, ...
Robinson Susan J SJ Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, GA 30333, USA. - - 2013
Recognizing the need to work with all partners who have an interest in addressing sexual health issues, we explored values held by diverse stakeholders in the United States. Based on these findings, we developed a framework for use in communicating about sexual health issues and potential solutions. Our methods included ...
Smylie Lisa L Public Health Agency of Canada, Centre for Communicable Diseases and Infection Control, Ottawa, Ontario, Canada. - - 2013
We developed and validated a set of self-administered, multi-dimensional indicators of sexual health among Canadians aged 16-24 years. This study used a mixed-method qualitative and quantitative approach to develop and validate indicators of sexual health. We used the four-stage Dillman method to identify, focus-test, pilot-test, and validate key metrics to ...
Thomas Rosalind R New York State Department of Health, AIDS Institute, Bureau of STD Prevention and Epidemiology, Albany, NY 12237, USA. - - 2013
We assessed public views about the acceptability of and need for sexually transmitted disease (STD) and sexual health-related educational messaging in local campaigns. A 28-item state-added module was included in the 2008 New York Behavioral Risk Factor Surveillance System survey (n=3,751). Respondents rated acceptability of venues/dissemination channels and messaging and ...
Lim S H SH Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, South - - 2013
The purpose of this study is to determine the efficacy of half-fluence photodynamic therapy (PDT) depending on the degree of hyperfluorescence based on indocyanine green angiography (ICGA) for treatment of chronic central serous chorioretinopathy (CSC). We conducted a prospective study of 30 eyes of 30 patients with chronic CSC. Half-fluence ...
Rundle Andrew A Department of Epidemiology, Mailman School of Public Health, 722 West 168th Street, Room730, New York, NY 10032, USA. - - 2013
To determine whether body mass index (BMI) is associated with proximity to neighborhood parks, the size of the parks, their cleanliness, and the availability of recreational facilities in the parks. Cross-sectional. New York City. Adults (13,102) were recruited from 2000 to 2002 (median age 45 years, 36% male). Anthropometric and ...
Rudy Yoram Y Cardiac Bioelectricity and Arrhythmia Center, Washington University, One Brookings Dr, St Louis, MO 63130-4899, USA. - - 2013
Cardiac excitation is determined by interactions between the source of electric activation (membrane depolarization) and the load that cardiac tissue presents. This relationship is altered in pathology by remodeling processes that often create a substrate favoring the development of cardiac arrhythmias. Most studies of arrhythmia mechanisms and arrhythmogenic substrates have ...
Bergamaschi Mateus M MM Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, - - 2013
Cannabis is the illicit drug most frequently reported with impaired driving and motor vehicle accidents. Some "per se" laws make it illegal to drive with any amount of drug in the body, while others establish blood, saliva, or urine concentrations above which it is illegal to drive. The persistence of ...
Heaton Lisa J LJ Department of Oral Health Sciences, School of Dentistry, University of Washington, 1959 N.E. Pacific St., Box 357475, Seattle, Wash. 98195-7475, USA. - - 2013
Mental illness (MI) affects approximately one in five U.S. adults, and it is associated with oral disease and poor dental treatment outcomes. Little is known about dental care utilization or unmet dental need in this population. The authors examined data regarding presence or absence of dental visits and unmet dental ...
Oren Eyal E University of Washington, Department of Epidemiology, Seattle, WA, USA. - - 2013
Lower socioeconomic status (SES) is associated with increased risk of tuberculosis (TB) and diagnostic delays, but the extent to which this association reflects an underlying gradient in advanced status of pulmonary TB is unknown. We conducted a multilevel retrospective cohort analysis examining the relationship between socioeconomic characteristics and pulmonary TB ...
Lanzkron Sophie S Johns Hopkins School of Medicine, Department of Medicine, Baltimore, MD 21205, USA. - - 2013
Improvements in survival for children with sickle cell disease (SCD) during the last 30 years have been well established. Whether similar improvements for adults with the disease have occurred is unknown. We investigated mortality rates for children and adults with SCD. We used the National Center for Health Statistics multiple-cause-of-death ...
Biello Katie Brooks KB The Fenway Institute, Fenway Health, Boston, MA 02215, USA. - - 2013
The age of adolescents at first sexual intercourse is an important risk factor for sexually transmitted diseases (STDs) and adolescent pregnancy. Black adolescents are at higher risk than white adolescents for first sexual intercourse at younger ages as well as STDs and pregnancy. Individual- and family-level factors do not fully ...
Ivankovich Megan B MB Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, GA 30333, - - 2013
To identify opportunities within nationally representative surveys and surveillance systems to measure indicators of sexual health, we reviewed and inventoried existing data systems that include variables relevant to sexual health. We searched for U.S. nationally representative surveys and surveillance systems that provided individual-level sexual health data. We assessed the methods ...
Nystrom Robert J RJ Oregon Public Health Division, Adolescent, Genetic and Reproductive Health Section, Portland, OR 97232, USA. - - 2013
Oregon's work on teen pregnancy prevention during the previous 20 years has shifted from a risk-focused paradigm to a youth development model that places young people at the center of their sexual health and well-being. During 2005, the Oregon Governor's Office requested that an ad hoc committee of state agency ...
Ivankovich Megan B MB Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, GA 30333, - - 2013
Nations across the globe face significant public heath challenges in optimizing sexual health, including reducing human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), sexually transmitted infections (STIs), unintended pregnancies, and sexual violence, and mitigating the associated adverse social and economic impacts. In response, some countries have implemented national strategies and other ...
Fung Ka Yee KY Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, - - 2013
The innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-ε as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, ...
Potter Patricia P Patient Care Services, Barnes-Jewish Hospital, USA. - - 2013
To evaluate a resiliency program designed to educate oncology nurses about compassion fatigue. Descriptive pilot study. A National Cancer Institute-designated comprehensive cancer center in the midwestern United States. 13 oncology nurses employed in an outpatient infusion center. Nurses attended a five-week program involving five 90-minute sessions on compassion fatigue resiliency. ...
Vacek Thomas P TP Department of Physiology and Biophysics, University of Louisville School of Medicine Louisville, Louisville, KY 40202, - - 2013
Bone remodeling is a very complex process. Homocysteine (Hcy) is known to modulate this process via several known mechanisms such as increase in osteoclast activity, decrease in osteoblast activity and direct action of Hcy on bone matrix. Evidence from previous studies further support a detrimental effect on bone via decrease ...
Chang Jennifer S JS Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, - - 2013
Spt10 is a putative acetyltransferase of Saccharomyces cerevisiae that directly activates the transcription of histone genes. Deletion of SPT10 causes a severe slow growth phenotype, showing that Spt10 is critical for normal cell division. To gain insight into the function of Spt10, we identified mutations that impair or improve the ...
Vickers Andrew J AJ Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer, 307 East 63rd Street, 2nd Floor, New York, NY 10065, USA. - - 2013
In September 2012 the Acupuncture Trialists' Collaboration published the results of an individual patient data meta-analysis of almost 18 000 patients in high quality randomised trials. The results favoured acupuncture. Although there was little argument about the findings in the scientific press, a controversy played out in blog posts and ...
Black Sarah Wurts SW Biosciences Division, SRI International, Menlo Park, CA 94025, USA. - - 2013
Humans with narcolepsy and orexin/ataxin-3 transgenic (TG) mice exhibit extensive, but incomplete, degeneration of hypo-cretin (Hcrt) neurons. Partial Hcrt cell loss also occurs in Parkinson disease and other neurologic conditions. Whether Hcrt antagonists such as almorexant (ALM) can exert an effect on the Hcrt that remains after Hcrt neurodegeneration has ...
Evans Daniel S DS California Pacific Medical Center Research Institute, San Francisco, CA 94107-1728, - - 2013
To determine the association between common genetic variation in the clock gene pathway and objectively measured acti-graphic sleep and activity rhythm traits. Genetic association study in two population-based cohorts of elderly participants: the Study of Osteoporotic Fractures (SOF) and the Osteoporotic Fractures in Men (MrOS) study. Population-based. SOF participants (n ...
Bowen Shelly-Ann SA Institute for Families in Society, University of South Carolina, 1600 Hampton Street, Suite 507, Columbia, SC 29208, USA. - - 2013
The study uses qualitative research to gain a better understanding of what occurs after low-income women receive an abnormal breast screening and the factors that influence their decisions and behavior. A heuristic model is presented for understanding this complexity. Qualitative research methods used to elicited social and cultural themes related ...
Cunha-Cruz Joana J Department of Oral Health Sciences, School of Dentistry, University of Washington, 1959 N.E. Pacific St., Seattle, Wash. 98195-7475, USA. - - 2013
The prevalence of dentin hypersensitivity is uncertain, yet appropriate diagnosis and treatment of dentin hypersensitivity require accurate knowledge regarding its prevalence. The authors conducted a study to estimate the prevalence of dentin hypersensitivity in general dental practices and to investigate associated risk factors. The authors conducted a cross-sectional survey of ...
Wu Beibei B Department of Microbiology and Molecular Genetics, School of Medicine, University of California Irvine, Irvine, CA 92697, - - 2013
T-cell factor/lymphoid enhancer factor (TCF/LEF) proteins regulate transcription by recruiting β-catenin and its associated co-regulators. Whether TCF/LEFs also recruit more factors through independent, direct interactions is not well understood. Here we discover Ring Finger Protein 14 (RNF14) as a new binding partner for all TCF/LEF transcription factors. We show that ...
Siminoff Laura A LA Virginia Commonwealth University, Richmond, VA, USA. - - 2013
Successful transplant medicine hinges on consent to deceased organ donation. Yet rates of consent remain suboptimal. To increase the availability of transplantable organs, several policy strategies along with a rich body of evidence aimed at identifying best practices for obtaining consent have accumulated. This review describes past and current policies ...
Giovanoli Sandra S Physiology and Behavior Laboratory, Swiss Federal Institute of Technology (ETH) Zurich, 8603 Schwerzenbach, - - 2013
Prenatal infection and exposure to traumatizing experiences during peripuberty have each been associated with increased risk for neuropsychiatric disorders. Evidence is lacking for the cumulative impact of such prenatal and postnatal environmental challenges on brain functions and vulnerability to psychiatric disease. Here, we show in a translational mouse model that ...
Diop B - - 2013
In Africa, difficulties in health care access and illiteracy promote the development of giant inguinal hernias. Management of these hernias can be very challenging, according to the risk of replacing the intestines into the abdominal cavity. We report five cases in Senegal.
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