Search Results
Results 451 - 500 of 2912
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Lee Junghee J Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, USA. - - 2013
This study aimed to determine the relative extent of impairment in social and nonsocial cognitive domains in patients with bipolar disorder compared with schizophrenia patients and healthy comparison subjects. Sixty-eight clinically stable outpatients with bipolar disorder, 38 clinically stable outpatients with schizophrenia, and 36 healthy comparison subjects completed a range ...
Pawl Jean D JD School of Nursing, Georgia State University, Atlanta, GA, USA. - - 2013
To describe the sleep characteristics of family caregivers of individuals with a primary malignant brain tumor (PMBT). Cross-sectional, correlational design using baseline data from a longitudinal study. Neuro-oncology and neurosurgery clinics at an urban tertiary medical center in the United States. 133 family caregivers recruited one to two months following ...
Arnedt J Todd JT Sleep and Chronophysiology Laboratory, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109-2700, USA. - - 2013
To compare the efficacy of telephone-delivered cognitive-behavioral therapy for insomnia to an information pamphlet control on sleep and daytime functioning at pretreatment, posttreatment, and 12-wk follow-up. Randomized controlled parallel trial. N/A. Thirty individuals with chronic insomnia (27 women, age 39.1 ± 14.4 years, insomnia duration 8.7 ± 10.7 years). Cognitive ...
Tingen Martha S MS Child Health Discovery Institute, Georgia Prevention Institute, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA. - - 2013
This study evaluated similarities and differences of enrollment rates using two different recruitment strategies for a tobacco control trial in rural and urban African-American (AA) elementary school families. A comparative study, nested within a larger randomized controlled trial, was used to test the effectiveness of two recruitment approaches on enrollment ...
Scheiermann Patrick - - 2013
Multidrug-resistant Gram-negative induced sepsis poses an increasing threat to the vulnerable intensive care patient. The study by Toufekoula and colleagues reports the serum and tissue concentration of malondialdehyde (MDA), the toxic end product of lipid peroxidation, during the course of experimental and human Gram-negative sepsis. The complementary results from this ...
MacDonald Michael R Bob MR Navy and Marine Corps Public Health Center, Sexual Health and Responsibility Program, Portsmouth, VA 23708, USA. - - 2013
In 1999, the Navy and Marine Corps Public Health Center converted an HIV train-the-trainer program into a broader effort of preventing not just HIV, but also other sexually transmitted infections (STIs) and unplanned pregnancies. The premise for this broader approach was that a more comprehensive sexual health promotion message of ...
White Stuart F SF National Institute of Mental Health, Bethesda, MD, USA. - - 2013
Youths with disruptive behavior disorders, including conduct disorder and oppositional defiant disorder, show major impairments in reinforcement-based decision making. However, the neural basis of these difficulties remains poorly understood. This partly reflects previous failures to differentiate responses during decision making and feedback processing and to take advantage of computational model-based ...
Pandit Sandeep V SV Center for Arrhythmia Research, University of Michigan, NCRC, 2800 Plymouth Rd, Ann Arbor, MI 48109, - - 2013
The objective of this article is to present a broad review of the role of cardiac electric rotors and their accompanying spiral waves in the mechanism of cardiac fibrillation. At the outset, we present a brief historical overview regarding reentry and then discuss the basic concepts and terminologies pertaining to ...
Yang Lawrence H LH Department of Epidemiology, Columbia University, New York, NY 10032, USA. - - 2013
This study compared stigma associated with the psychosis risk label and diagnostic labels for nonpsychotic and psychotic mental disorders among young adult peers. Urban college respondents (N=153) read an experimental vignette describing a young adult experiencing prodromal symptoms who was randomly assigned a diagnostic label (major depression, generalized anxiety disorder, ...
Bertolli Jeanne J Centers for Disease Control and Prevention, Division of HIV/AIDS Prevention, Atlanta, GA 30333, USA. - - 2013
Clinical interventions that lengthen life after HIV infection and significantly reduce transmission could have greater impact if more HIV-diagnosed people received HIV care. We tested a surveillance-based approach to investigating reasons for delayed entry to care. Health department staff in three states and two cities contacted eligible adults diagnosed with ...
Penman-Aguilar Ana A Centers for Disease Control and Prevention, Office of Minority Health and Health Equity, Atlanta, GA 30333, USA. - - 2013
We reviewed the literature focused on socioeconomic influences on teen childbearing and suggested directions for future research and practice related to this important indicator of teen sexual health. We conducted an electronic search of Medline, ERIC, PsychLit, and Sociological Abstracts databases for articles published from January 1995 to November 2011. ...
Murray Colleen Crittenden CC Emory University, Rollins School of Public Health, Atlanta, GA 30322, USA. - - 2013
We assessed young African American women's understanding of "dual protection" (DP) (i.e., strategies that simultaneously protect against unintended pregnancies and sexually transmitted diseases [STDs]) and how relationship factors influence their use of DP methods. We conducted 10 focus groups with African American women (n=51) aged 15-24 years in Atlanta, Georgia, ...
Robinson Susan J SJ Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, GA 30333, USA. - - 2013
Recognizing the need to work with all partners who have an interest in addressing sexual health issues, we explored values held by diverse stakeholders in the United States. Based on these findings, we developed a framework for use in communicating about sexual health issues and potential solutions. Our methods included ...
Smylie Lisa L Public Health Agency of Canada, Centre for Communicable Diseases and Infection Control, Ottawa, Ontario, Canada. - - 2013
We developed and validated a set of self-administered, multi-dimensional indicators of sexual health among Canadians aged 16-24 years. This study used a mixed-method qualitative and quantitative approach to develop and validate indicators of sexual health. We used the four-stage Dillman method to identify, focus-test, pilot-test, and validate key metrics to ...
Thomas Rosalind R New York State Department of Health, AIDS Institute, Bureau of STD Prevention and Epidemiology, Albany, NY 12237, USA. - - 2013
We assessed public views about the acceptability of and need for sexually transmitted disease (STD) and sexual health-related educational messaging in local campaigns. A 28-item state-added module was included in the 2008 New York Behavioral Risk Factor Surveillance System survey (n=3,751). Respondents rated acceptability of venues/dissemination channels and messaging and ...
Lim S H SH Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, South - - 2013
The purpose of this study is to determine the efficacy of half-fluence photodynamic therapy (PDT) depending on the degree of hyperfluorescence based on indocyanine green angiography (ICGA) for treatment of chronic central serous chorioretinopathy (CSC). We conducted a prospective study of 30 eyes of 30 patients with chronic CSC. Half-fluence ...
Rundle Andrew A Department of Epidemiology, Mailman School of Public Health, 722 West 168th Street, Room730, New York, NY 10032, USA. - - 2013
To determine whether body mass index (BMI) is associated with proximity to neighborhood parks, the size of the parks, their cleanliness, and the availability of recreational facilities in the parks. Cross-sectional. New York City. Adults (13,102) were recruited from 2000 to 2002 (median age 45 years, 36% male). Anthropometric and ...
Bergamaschi Mateus M MM Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, - - 2013
Cannabis is the illicit drug most frequently reported with impaired driving and motor vehicle accidents. Some "per se" laws make it illegal to drive with any amount of drug in the body, while others establish blood, saliva, or urine concentrations above which it is illegal to drive. The persistence of ...
Heaton Lisa J LJ Department of Oral Health Sciences, School of Dentistry, University of Washington, 1959 N.E. Pacific St., Box 357475, Seattle, Wash. 98195-7475, USA. - - 2013
Mental illness (MI) affects approximately one in five U.S. adults, and it is associated with oral disease and poor dental treatment outcomes. Little is known about dental care utilization or unmet dental need in this population. The authors examined data regarding presence or absence of dental visits and unmet dental ...
Oren Eyal E University of Washington, Department of Epidemiology, Seattle, WA, USA. - - 2013
Lower socioeconomic status (SES) is associated with increased risk of tuberculosis (TB) and diagnostic delays, but the extent to which this association reflects an underlying gradient in advanced status of pulmonary TB is unknown. We conducted a multilevel retrospective cohort analysis examining the relationship between socioeconomic characteristics and pulmonary TB ...
Lanzkron Sophie S Johns Hopkins School of Medicine, Department of Medicine, Baltimore, MD 21205, USA. - - 2013
Improvements in survival for children with sickle cell disease (SCD) during the last 30 years have been well established. Whether similar improvements for adults with the disease have occurred is unknown. We investigated mortality rates for children and adults with SCD. We used the National Center for Health Statistics multiple-cause-of-death ...
Ivankovich Megan B MB Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, GA 30333, - - 2013
To identify opportunities within nationally representative surveys and surveillance systems to measure indicators of sexual health, we reviewed and inventoried existing data systems that include variables relevant to sexual health. We searched for U.S. nationally representative surveys and surveillance systems that provided individual-level sexual health data. We assessed the methods ...
Nystrom Robert J RJ Oregon Public Health Division, Adolescent, Genetic and Reproductive Health Section, Portland, OR 97232, USA. - - 2013
Oregon's work on teen pregnancy prevention during the previous 20 years has shifted from a risk-focused paradigm to a youth development model that places young people at the center of their sexual health and well-being. During 2005, the Oregon Governor's Office requested that an ad hoc committee of state agency ...
Ivankovich Megan B MB Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, GA 30333, - - 2013
Nations across the globe face significant public heath challenges in optimizing sexual health, including reducing human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), sexually transmitted infections (STIs), unintended pregnancies, and sexual violence, and mitigating the associated adverse social and economic impacts. In response, some countries have implemented national strategies and other ...
Fung Ka Yee KY Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, - - 2013
The innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-ε as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, ...
Potter Patricia P Patient Care Services, Barnes-Jewish Hospital, USA. - - 2013
To evaluate a resiliency program designed to educate oncology nurses about compassion fatigue. Descriptive pilot study. A National Cancer Institute-designated comprehensive cancer center in the midwestern United States. 13 oncology nurses employed in an outpatient infusion center. Nurses attended a five-week program involving five 90-minute sessions on compassion fatigue resiliency. ...
Vacek Thomas P TP Department of Physiology and Biophysics, University of Louisville School of Medicine Louisville, Louisville, KY 40202, - - 2013
Bone remodeling is a very complex process. Homocysteine (Hcy) is known to modulate this process via several known mechanisms such as increase in osteoclast activity, decrease in osteoblast activity and direct action of Hcy on bone matrix. Evidence from previous studies further support a detrimental effect on bone via decrease ...
Chang Jennifer S JS Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, - - 2013
Spt10 is a putative acetyltransferase of Saccharomyces cerevisiae that directly activates the transcription of histone genes. Deletion of SPT10 causes a severe slow growth phenotype, showing that Spt10 is critical for normal cell division. To gain insight into the function of Spt10, we identified mutations that impair or improve the ...
Black Sarah Wurts SW Biosciences Division, SRI International, Menlo Park, CA 94025, USA. - - 2013
Humans with narcolepsy and orexin/ataxin-3 transgenic (TG) mice exhibit extensive, but incomplete, degeneration of hypo-cretin (Hcrt) neurons. Partial Hcrt cell loss also occurs in Parkinson disease and other neurologic conditions. Whether Hcrt antagonists such as almorexant (ALM) can exert an effect on the Hcrt that remains after Hcrt neurodegeneration has ...
Evans Daniel S DS California Pacific Medical Center Research Institute, San Francisco, CA 94107-1728, - - 2013
To determine the association between common genetic variation in the clock gene pathway and objectively measured acti-graphic sleep and activity rhythm traits. Genetic association study in two population-based cohorts of elderly participants: the Study of Osteoporotic Fractures (SOF) and the Osteoporotic Fractures in Men (MrOS) study. Population-based. SOF participants (n ...
Bowen Shelly-Ann SA Institute for Families in Society, University of South Carolina, 1600 Hampton Street, Suite 507, Columbia, SC 29208, USA. - - 2013
The study uses qualitative research to gain a better understanding of what occurs after low-income women receive an abnormal breast screening and the factors that influence their decisions and behavior. A heuristic model is presented for understanding this complexity. Qualitative research methods used to elicited social and cultural themes related ...
Wu Beibei B Department of Microbiology and Molecular Genetics, School of Medicine, University of California Irvine, Irvine, CA 92697, - - 2013
T-cell factor/lymphoid enhancer factor (TCF/LEF) proteins regulate transcription by recruiting β-catenin and its associated co-regulators. Whether TCF/LEFs also recruit more factors through independent, direct interactions is not well understood. Here we discover Ring Finger Protein 14 (RNF14) as a new binding partner for all TCF/LEF transcription factors. We show that ...
Siminoff Laura A LA Virginia Commonwealth University, Richmond, VA, USA. - - 2013
Successful transplant medicine hinges on consent to deceased organ donation. Yet rates of consent remain suboptimal. To increase the availability of transplantable organs, several policy strategies along with a rich body of evidence aimed at identifying best practices for obtaining consent have accumulated. This review describes past and current policies ...
Giovanoli Sandra S Physiology and Behavior Laboratory, Swiss Federal Institute of Technology (ETH) Zurich, 8603 Schwerzenbach, - - 2013
Prenatal infection and exposure to traumatizing experiences during peripuberty have each been associated with increased risk for neuropsychiatric disorders. Evidence is lacking for the cumulative impact of such prenatal and postnatal environmental challenges on brain functions and vulnerability to psychiatric disease. Here, we show in a translational mouse model that ...
Zelle Kathleen M KM Department of Biology, Washington University in St. Louis, St. Louis, Missouri 63130, - - 2013
Degenerin/epithelial sodium channels (DEG/ENaC) represent a large family of animal-specific membrane proteins. Although the physiological functions of most family members are not known, some have been shown to act as nonvoltage gated, amiloride-sensitive sodium channels. The DEG/ENaC family is exceptionally large in genomes of Drosophila species relative to vertebrates and ...
Tilgner Hagen H Department of Genetics, Stanford University, Stanford, California 94305, - - 2013
Precise identification of RNA-coding regions and transcriptomes of eukaryotes is a significant problem in biology. Currently, eukaryote transcriptomes are analyzed using deep short-read sequencing experiments of complementary DNAs. The resulting short-reads are then aligned against a genome and annotated junctions to infer biological meaning. Here we use long-read complementary DNA ...
Biello Katie Brooks KB The Fenway Institute, Fenway Health, Boston, MA 02215, USA. - - 2013
The age of adolescents at first sexual intercourse is an important risk factor for sexually transmitted diseases (STDs) and adolescent pregnancy. Black adolescents are at higher risk than white adolescents for first sexual intercourse at younger ages as well as STDs and pregnancy. Individual- and family-level factors do not fully ...
Dolfini D D Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, Milan 20133, - - 2013
The Y box is an important sequence motif found in promoters and enhancers containing a CCAAT box - one of the few elements enriched in promoters of large sets of genes overexpressed in cancer. The search for the transcription factor(s) acting on it led to the biochemical purification of the ...
Gharbiya M M Department of Ophthalmology, Sapienza University, Umberto I Hospital, Rome, Italy. - - 2013
To determine macular thickness changes after uncomplicated cataract surgery using spectral domain optical coherence tomography (OCT). This was a prospective non-randomized, clinical study. Data were analysed for 40 healthy patients undergoing uneventful phacoemulsification. OCT measurements were performed before surgery and postoperatively at day 1, week 1 and 2, and month ...
Basu S S L V Prasad Eye Institute, Bhubaneswar, India. - - 2013
To analyze the incidence and clinical course of patients developing progressive ocular inflammation following anti-tubercular therapy (ATT) for presumed ocular tuberculosis (TB). Retrospective analysis of medical records of patients who received ATT for presumed ocular TB and completed at least 12 months follow-up after initiation of ATT. The diagnosis of ...
Rahman R R Department of Ophthalmology, Calderdale Royal Hospital, Halifax, West Yorkshire, UK. - - 2013
To describe the incidence and features of intraoperative retinal breaks caused by induction of posterior hyaloid face (PHF) separation during 23-gauge pars plana vitrectomy (PPV). A prospective, consecutive, single surgeon, observational study of patients undergoing 23-gauge transconjunctival sutureless vitrectomy for macular pathology or floaters, was carried out between 2009 and ...
Jackson T L TL King's College London, Department of Opthalmology, King's College Hospital, London, UK. - - 2013
To report the vitreoretinal (VR) surgical case mix in the United Kingdom, the intraoperative complication rate of pars plana vitrectomy (PPV), and the incidence of post-vitrectomy cataract extraction. Participating hospitals prospectively collected ophthalmic data using a single electronic medical record system, with automatic extraction of anonymised data to a national ...
Qiu Penghe P Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK 73019, - - 2013
A novel scaffold composed of loosely branched hollow silica microfibers that has been proven to be highly biocompatible is proposed for the 3D culture of cancer cells. The MCF-7 cancer cells can grow and proliferate freely inside the scaffold in the form of multicellular spheroids. MCF-7 cancer cells cultured on ...
Sutton Jonathan T JT University of Cincinnati, College of Medicine, Internal Medicine, Division of Cardiovascular Diseases, and Biomedical Engineering Program, Cincinnati, OH, - - 2013
Ultrasound (US) has been developed as both a valuable diagnostic tool and a potent promoter of beneficial tissue bioeffects for the treatment of cardiovascular disease. These effects can be mediated by mechanical oscillations of circulating microbubbles, or US contrast agents, which may also encapsulate and shield a therapeutic agent in ...
Bohgaki M M Ontario Cancer Institute, University Health Network and Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario, - - 2013
The serine threonine kinase checkpoint kinase 2 (CHK2) is a DNA damage checkpoint protein important for the ATM-p53 signaling pathway. In addition to its phosphorylation, CHK2 is also ubiquitylated, and both post-translational modifications are important for its function. However, although the mechanisms that regulate CHK2 phosphorylation are well established, those ...
Cunha-Cruz Joana J Department of Oral Health Sciences, School of Dentistry, University of Washington, 1959 N.E. Pacific St., Seattle, Wash. 98195-7475, USA. - - 2013
The prevalence of dentin hypersensitivity is uncertain, yet appropriate diagnosis and treatment of dentin hypersensitivity require accurate knowledge regarding its prevalence. The authors conducted a study to estimate the prevalence of dentin hypersensitivity in general dental practices and to investigate associated risk factors. The authors conducted a cross-sectional survey of ...
Matthaei Mario M Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, - - 2013
To investigate the endothelial gene expression profile in a Col8a2 Q455K mutant knock-in mouse model of early-onset Fuchs' endothelial corneal dystrophy (FECD) and identify potential targets that can be correlated to human late-onset FECD. Diseased or normal endothelial phenotypes were verified in 12-month-old homozygous Col8a2(Q455K/Q455K) mutant and wild-type mice by ...
Vickers Andrew J AJ Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer, 307 East 63rd Street, 2nd Floor, New York, NY 10065, USA. - - 2013
In September 2012 the Acupuncture Trialists' Collaboration published the results of an individual patient data meta-analysis of almost 18 000 patients in high quality randomised trials. The results favoured acupuncture. Although there was little argument about the findings in the scientific press, a controversy played out in blog posts and ...
Farhang Ghahremani M M Department for Molecular Biomedical Research, VIB, Ghent, - - 2013
There is growing evidence that the p53 tumour suppressor downregulates vascular endothelial growth factor (VEGF) expression, although the underlying mechanisms remain unclear and controversial. Here we provide insights from in vitro experiments and in vivo xenotransplantation assays that highlight a dual role for p53 in regulating VEGF during hypoxia. Unexpectedly, ...
Carrera S S Department of Biochemistry, University of Leicester, Leicester, - - 2013
Stra6 is the retinoic acid (RA)-inducible gene encoding the cellular receptor for holo-retinol binding protein. This transmembrane protein mediates the internalization of retinol, which then upregulates RA-responsive genes in target cells. Here, we show that Stra6 can be upregulated by DNA damage in a p53-dependent manner, and it has an ...
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