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Kashikar-Zuck Susmita S Divisions of *Behavioral Medicine and Clinical Psychology ‡Neurology §Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center †Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, - - 2013
Chronic pain in children is associated with significant negative impact on social, emotional, and school functioning. Previous studies on the impact of pain on children's functioning have primarily used mixed samples of pain conditions or single pain conditions (eg, headache and abdominal pain) with relatively small sample sizes. As a ...
McCreery Ryan W RW Boys Town National Research Hospital, Omaha, NE 68131, USA. - - 2013
Understanding speech in acoustically degraded environments can place significant cognitive demands on school-age children who are developing the cognitive and linguistic skills needed to support this process. Previous studies suggest the speech understanding, word learning, and academic performance can be negatively impacted by background noise, but the effect of limited ...
Ang Dennis C DC Department of Medicine, Division of Rheumatology, Indiana University, Indianapolis, IN 46202, - - 2013
To evaluate the feasibility of a randomized-controlled trial and to obtain estimates of the effects of combined cognitive-behavioral therapy (CBT) and milnacipran for the treatment of fibromyalgia. Fifty-eight patients with fibromyalgia were randomized to 1 of the 3 treatment arms: (1) combination therapy (n = 20); (2) milnacipran+education (n = ...
Simonen Marko M Department of Medicine, University of Eastern Finland and Kuopio University Hospital, - - 2013
Dysregulation of the cholesterol synthesis pathway and accumulation of cholesterol in the liver are linked to the pathogenesis of nonalcoholic steatohepatitis (NASH). Therefore, we investigated the association of serum and liver levels of cholesterol precursors with NASH. Liver histology was assessed in 110 obese patients (Kuopio Obesity Surgery Study [KOBS] ...
Chiang Sharon S Department of Statistics, Rice University, Houston, Texas, - - 2013
Chemokines and their receptors are important mediators of inflammation. Guillain-Barré syndrome (GBS) is the most common cause of acute paralysis worldwide. Despite current treatments, outcomes are suboptimal. Specific chemokine receptor antagonists have the potential to be efficacious against pathogenic leukocyte trafficking in GBS. A 36-year literature review was performed to ...
Gifford René H RH Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN, - - 2013
The aim of this study was to assess the benefit of having preserved acoustic hearing in the implanted ear for speech recognition in complex listening environments. The present study included a within-subjects, repeated-measures design including 21 English-speaking and 17 Polish-speaking cochlear implant (CI) recipients with preserved acoustic hearing in the ...
Qiang Judy K JK Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, - - 2013
To identify plasma-based biomarkers for Parkinson disease (PD) risk. In a discovery cohort of 152 PD patients, plasma levels of 96 proteins were measured by multiplex immunoassay; proteins associated with age at PD onset were identified by linear regression. Findings from discovery screening were then assessed in a second cohort ...
Kim Ki-Tack KT Department of Orthopaedic Surgery, Spine Center, Kyung Hee University Hospital at Gangdong, Seoul, - - 2013
A retrospective study. To describe the technique of a partial pedicle subtraction osteotomy (PPSO) and to report on the clinical and radiological outcomes. Numerous corrective osteotomy techniques have been reported. Until now, there has been no reported method that can achieve a correction angle between those of the Smith-Petersen osteotomy ...
Kabumoto Ken-ichiro K Department of Bio-Application and Systems Engineering, Tokyo University of Agriculture and Technology, Tokyo, - - 2013
We have developed a living prosthesis consisting of a living muscle-powered device, which is controlled by neuronal signals to recover some of the functions of a lost extremity. A tissue-engineered skeletal muscle was fabricated with two anchorage points from a primary rat myoblast cultured in a collagen Matrigel mixed gel. ...
Moghadamrad Sheida S Department of Clinical Research, Hepatology Study Group, University of Berne, - - 2013
Cholestasis with normal gamma glutamyl transferase characterizes functional deficiencies in the gene ABCB11, which encodes the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter. Here we report the case of a patient presenting with features of benign recurrent intrahepatic cholestasis associated with a heterozygous mutation in ...
Weier Christopher C Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, - - 2013
TMPRSS2-ERG rearrangements occur in approximately 50% of prostate cancers and therefore represent one of the most frequently observed structural rearrangements in all cancers. However, little is known about the genomic architecture of such rearrangements. We therefore designed and optimized a pipeline involving target capture of TMPRSS2 and ERG genomic sequences ...
Deblonde Gauthier J-P GJ Chemical Sciences Division, Glenn T. Seaborg Center, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, - - 2013
Following an internal contamination event, the transport of actinide (An) and lanthanide (Ln) metal ions through the body is facilitated by endogenous ligands such as the human iron-transport protein transferrin (Tf). The recognition of resulting metallo-transferrin complexes (M2Tf) by the cognate transferrin receptor (TfR) is therefore a critical step for ...
Briggs Sarah S Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, - - 2013
Polymerases ε and δ are the main enzymes that replicate eukaryotic DNA. Accurate replication occurs through Watson-Crick base pairing and also through the action of the polymerases' exonuclease (proofreading) domains. We have recently shown that germline exonuclease domain mutations (EDMs) of POLE and POLD1 confer a high risk of multiple ...
Pa Judy J Department of Neurology, University of California, San Francisco, San Francisco, CA, - - 2013
The importance of the cholinergic system for cognitive function has been well documented in animal and human studies. The objective of this study was to elucidate the cognitive and functional connectivity changes associated with enhanced acetylcholine levels. We hypothesized that older adults with mild memory deficits would show behavioral and ...
Zhang XiChun X Departments of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, - - 2013
To examine changes in the response properties of meningeal nociceptors that might lead to migraine pain and examine endogenous processes that could play a role in mediating them using a clinically relevant model of migraine triggering, namely infusion of the nitric oxide (NO) donor nitroglycerin (NTG). Single-unit recordings made in ...
Fineberg Steven J SJ Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL 60612, - - 2013
Retrospective national database analysis. A national population-based database was analyzed to characterize cervical spine procedures performed at teaching and nonteaching hospitals with regards to patient demographics, clinical outcomes/complications, resource use, and costs. There are mixed reports in the literature regarding the quality and costs of health care provided by teaching ...
Yanik Elizabeth L EL Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, USA. - - 2013
We assessed laboratory monitoring after combination antiretroviral therapy initiation among 3678 patients in a large US multisite clinical cohort, censoring participants at last clinic visit, combination antiretroviral therapy change, or 3 years. Median days (interquartile range) to first hematologic, hepatic, renal, and lipid tests were 30 (18-53), 31 (19-56), 33 ...
Coleman Jenell S JS Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. - - 2013
The effect of the levonorgestrel-releasing intrauterine device (LNG-IUD) on genital HIV-1 RNA shedding and inflammation among 25 HIV-infected women was evaluated. Blood, endocervical, and cervicovaginal lavage samples were collected from HIV-infected women not taking antiretrovirals before LNG-IUD insertion and 1 month, 3 month, and 6 months thereafter. HIV-1 RNA was ...
Koblin Beryl A BA Laboratory of Infectious Disease Prevention, New York Blood Center, New York, NY 10065, USA. - - 2013
Identifying cohorts of US women with HIV infection rates sufficient for inclusion in vaccine efficacy trials has been challenging. Using geography and sexual network characteristics to inform recruitment strategies, HVTN 906 determined the feasibility of recruiting a cohort of women at high risk for HIV acquisition. HIV uninfected women who ...
Muramatsu Shunsuke S Department of Hepato-Biliary-Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, - - 2013
Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies because of recurrence and/or metastasis even after curative resection. Emerging evidence suggests that tumor metastasis and recurrence might be driven by a small subpopulation of stemness cells, so-called cancer stem cells (CSCs). Previous investigations have revealed that glioma and breast ...
Arena Umberto U Dipartimento di Medicina Interna; Università degli Studi di Firenze/Azienda Ospedaliero Universitaria Careggi (AOUC), Firenze, - - 2013
Transient elastography (TE) is increasingly employed in clinical practice for the noninvasive detection of tissue fibrosis in patients with chronic liver disease (CLD), and particularly chronic hepatitis C virus (HCV)-related hepatitis. The present study was designed to provide a definitive characterization of the "confounding" increase in liver stiffness (LS) following ...
Lan Peixiang P Institute of Immunopharmacology & Immunotherapy, School of Pharmaceutical Sciences, Shandong University, Shandong, - - 2013
Hepatitis B virus (HBV) persistence aggravates hepatic immunotolerance, leading to the failure of cell-intrinsic type I interferon and antiviral response, but whether and how HBV-induced hepatocyte-intrinsic tolerance influences systemic adaptive immunity has never been reported, which is becoming the major obstacle for chronic HBV therapy. In this study, an HBV-persistent ...
Gower Barbara A BA Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Blvd., Birmingham, AL 35294, USA. - - 2013
Diet-induced reduction in circulating insulin may be an attractive nonpharmacological treatment for women with polycystic ovary syndrome (PCOS) among whom elevated insulin may exacerbate symptoms by stimulating testosterone synthesis. This study was designed to determine whether a modest reduction in dietary carbohydrate (CHO) content affects β-cell responsiveness, serum testosterone concentration ...
Yoon Michael K MK Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, - - 2013
The Cutler-Beard procedure is a commonly used technique to reconstruct large upper eyelid defects. Eyelid retraction and entropion are common complications. To prevent these problems, the authors modified the traditional Cutler-Beard procedure with secondary placement of an autologous tarsoconjunctival graft. This is a retrospective review of 2 patients with large ...
Margolis David M DM Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7042, USA. - - 2013
A serious effort has begun to develop therapies that may be capable of eradicating established HIV infection in man. Because of the biological complexity of HIV infection that persists despite potent antiretroviral therapy, it is widely believed that if such therapies can be developed they will involve complex, multimodality approaches. ...
Morselli Lisa L LL Department of Medicine, Sleep, Metabolism and Health Center (SMAHC), University of Chicago, Chicago, Illinois 60637, USA. - - 2013
We previously reported that adult patients with GH deficiency (GHD) due to a confirmed or likely pituitary defect, compared with healthy controls individually matched for age, gender, and BMI, have more slow-wave sleep (SWS) and higher delta activity (a marker of SWS intensity). Here, we examined the impact of recombinant ...
Ahmad Zahid Z Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, UT Southwestern Medical Center, Dallas, Texas 75390, - - 2013
Hepatic steatosis is a common complication in patients with lipodystrophies and can lead to cirrhosis. There is no proven effective therapy for hepatic steatosis, but cholic acid (CA), a farnesoid X receptor agonist, has previously been shown to reduce hepatic triglyceride (TG) content in mice and serum TG in humans. ...
Roll Garrett R GR Division of Transplantation, Department of Surgery, University of California San Francisco, San Francisco, CA, - - 2013
Living donor liver transplantation (LDLT), originally used in children with left lateral segment grafts, has been expanded to adults who require larger grafts to support liver function. Most adult LDLT procedures have been performed with right lobe grafts, and this means a significant risk of morbidity for the donors. To ...
Porter Ned A NA Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, USA. - - 2013
This Perspective describes advances from the author's laboratory on the free radical reactions of organic compounds with molecular oxygen. Polyunsaturated fatty acids (PUFAs) and sterols are particularly prone to undergo radical chain oxidation, and evidence suggests that this process, known as lipid peroxidation, occurs in vivo under a variety of ...
Xu Z Z Department of Epidemiology, School of Public Health, Tianjin Medical University, Tianjin, - - 2013
Early detection of diabetes is important for the prevention of diabetic complications. The best adiposity index for indicating Type 2 diabetes mellitus remains unclear. We aimed to identify the optimal adiposity measure among BMI, waist circumference, waist-hip ratio and waist-to-height ratio to indicate undiagnosed Type 2 diabetes and impaired fasting ...
Goodnough Lawrence T - - 2013
Traditionally, trauma resuscitation protocols have advocated sequential administration of therapeutic components, beginning with crystalloid solutions infused to replace lost intravascular volume. However, rapid restoration of the components of blood is essential for ensuring adequate tissue perfusion and for preventing acidosis, coagulopathy, and hypothermia, referred to as the 'lethal triad' in ...
Siller Richard - - 2013
Recent progress in the field of cellular reprogramming has opened up the doors to a new era of disease modelling, as pluripotent stem cells representing a myriad of genetic diseases can now be produced from patient tissue. These cells can be expanded and differentiated to produce a potentially limitless supply ...
Benveniste Marcelo F K MF Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, - - 2013
Advanced thymoma (stage III and IV) is difficult to detect by computed tomography (CT), yet it is important to distinguish between early (stage I and II) and advanced disease before surgery, as patients with locally advanced tumors require neoadjuvant chemotherapy to enable effective resection. This study assessed whether the amount ...
Cantor-Graae Elizabeth E Lund University, Section for Social Medicine and Global Health, Department of Clinical Sciences, Malmö, Sweden. - - 2013
Although increased risk for schizophrenia among immigrants is well established, knowledge of the broader spectrum of psychiatric disorders associated with a foreign migration background is lacking. To examine the full range of psychiatric disorders associated with any type of foreign migration background among persons residing in Denmark, including foreign-born adoptees, ...
Wang Da D Department of Chemistry, The University of Michigan, 930 N University Ave, Ann Arbor, MI 48109, - - 2013
Intracellular zinc homeostasis is regulated by an extensive network of transporters, ligands and transcription factors. The zinc detoxification functions of three transporters and a periplasmic protein regulated by the BaeSR two-component system were explored in this work by evaluating the effect of single gene knockouts in the BaeSR regulon on ...
Hur Manhoi M Human Computer Interaction and Department of Genetics Development and Cell Biology, Iowa State University, Ames, IA 50011, USA. - - 2013
Discovering molecular components and their functionality is key to the development of hypotheses concerning the organization and regulation of metabolic networks. The iterative experimental testing of such hypotheses is the trajectory that can ultimately enable accurate computational modelling and prediction of metabolic outcomes. This information can be particularly important for ...
Dianat Noushin N INSERM UMR-S972, Paul Brousse Hospital, Villejuif, F-94807, - - 2013
The liver is affected by many types of diseases, including metabolic disorders and acute liver failure. Orthotopic liver transplantation (OLT) is currently the only effective treatment for life-threatening liver diseases but transplantation of allogeneic hepatocytes has now become an alternative as it is less invasive than OLT and can be ...
Leon-Salas Walter D WD Muscle Biology Research Group, Schools of Nursing & Medicine, University of Missouri Kansas City, 2464 Charlotte Street, Kansas City, MO 64108. - - 2013
This paper presents the design and test of a dual-mode electric and magnetic biological stimulator (EM-Stim). The stimulator generates pulsing electric and magnetic fields at programmable rates and intensities. While electric and magnetic stimulators have been reported before, this is the first device that combines both modalities. The ability of ...
Mandell M Susan MS Department of Anesthesiology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA. - - 2013
A new Organ Procurement and Transplantation Network/United Network for Organ Sharing bylaw recommends that all centers appoint a director of liver transplant anesthesia with a uniform set of criteria. We obtained survey data from the Liver Transplant Anesthesia Consortium so that we could compare existing criteria for a director in ...
Myers Michelle M Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, - - 2013
Intraovarian factors play important roles in coordinating germ cell and somatic cell growth in the ovary. Prior to the onset of gonadotropin stimulation and reproductive cyclicity, follicle development is dependent upon locally produced growth factors, such as the transforming growth factor beta family members inhibin, activin, and GDF9. In the ...
Nakamura Noriko N Gamete Biology Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, - - 2013
Sperm utilize glycolysis to generate ATP required for motility, and several spermatogenic cell-specific glycolytic isozymes are associated with the fibrous sheath (FS) in the principal piece of the sperm flagellum. We used proteomics and molecular biology approaches to confirm earlier reports that a novel enolase is present in mouse sperm. ...
Ross Lori E LE Social and Epidemiological Research Department, Centre for Addiction and Mental Health, University of Toronto, ON, Canada. - - 2013
Untreated depression during pregnancy has been associated with increased morbidity and mortality for both mother and child and, as such, optimal treatment strategies are required for this population. There are conflicting data regarding potential risks of prenatal antidepressant treatment. To determine whether prenatal antidepressant exposure is associated with risk for ...
Hangasky John A JA Department of Chemistry, University of Massachusetts, Amherst, MA 01003, - - 2013
The Fe(ii)/αketoglutarate (αKG) dependent oxygenases catalyze a diverse range of reactions significant in biological processes such as antibiotic biosynthesis, lipid metabolism, oxygen sensing, and DNA and RNA repair. Although functionally diverse, the eight-stranded β-barrel (cupin) and HX(D/E)XnH facial triad motifs are conserved in this super-family of enzymes. Crystal structure analysis ...
Wojcicki Janet M JM Division of GI, Hepatology and Nutrition, Department of Pediatrics, University of California, San Francisco, 500 Parnassus Avenue MU4E, San Francisco, CA 94134-0136, USA. - - 2013
While childhood obesity is a global problem, the extent and severity of the problem in United States, has resulted in a number of new initiatives, including recent hospital initiatives to limit the sale of sweetened beverages and other high calorie drinks in hospital vending machines and cafeterias. These proposed policy ...
Madathil Sindhu K SK Division of Cell Biology and Physiology, Laboratory of Clinical and Experimental Neuroscience, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India. - - 2013
Complex I deficiency culminating in oxidative stress is proposed as one of the upstream mechanisms of nigral neuronal death in Parkinson's disease. We investigated whether sodium salicylate, an active metabolite of aspirin, could afford protection against rotenone-induced oxidative stress, neuronal degeneration, and behavioral dysfunction in rats, because it has the ...
Pop Victor J VJ Department of Medical Health Psychology, University of Tilburg, Tilburg, the Netherlands. - - 2013
Obesity and too much weight gain during gestation have a negative effect on obstetric and neonatal outcomes. To determine the relationship between thyroid hormone parameters, body mass index (BMI) and weight gain during gestation. Prospective follow-up study of thyroid parameters and gestational weight gain. Healthy pregnant women, included at first ...
Sampson Natalie N Division of Experimental Urology, Department of Urology, Innsbruck Medical University, Anichstraße 35, A-6020 Innsbruck, - - 2013
Prostate cancer (PCa) is one of the most common causes of male cancer-related death in Western nations. The cellular response to androgens is mediated via the androgen receptor (AR), a ligand-inducible transcription factor whose dysregulation plays a key role during PCa development and progression following androgen deprivation therapy, the current ...
Romano S S Department of Medicine, University of Padua, Padua, - - 2013
Alström syndrome (ALMS) is a rare autosomal recessive monogenic disease included in an emerging class of genetic disorders called 'ciliopathies' and is likely to impact the central nervous system as well as metabolic and endocrine function. Individuals with ALMS present clinical features resembling a growth hormone deficiency (GHD) condition, but ...
Lu Tsai-Te TT Department of Chemistry, Massachusetts Institute of Technology , Cambridge, MA 02139, - - 2013
The mitochondrial membrane-bound enzyme Clock-1 (CLK-1) extends the average longevity of mice and Caenorhabditis elegans, as demonstrated for Δclk-1 constructs for both organisms. Such an apparent impact on aging and the presence of a carboxylate-bridged diiron center in the enzyme inspired this work. We expressed a soluble human CLK-1 (hCLK-1) ...
Bond Michael M Division of Clinical Sciences, Warwick Medical School, Coventry, CV4 7AL, UK; Medical Research Council Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, - - 2013
Ras signalling is central to fundamental and diverse cellular processes. In higher eukaryotes ras signalling is highly complex, involving multiple isoforms, regulatory proteins and effectors. As a consequence, the study of ras activity in mammalian systems presents a number of technical challenges. The model organism Schizosaccharomyces pombe has previously proved ...
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