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Results 401 - 450 of 2335
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Biron Kaan E - - 2013
Pathogenic neoangiogenesis in Alzheimer's disease (AD) is due to amyloid-beta (Aβ) and results in blood-brain barrier (BBB) leakiness in AD. It likely occurs as a compensatory response to impaired cerebral blood flow and provides a strong link between brain vascularity and AD. Aβ immunotherapy is an experimental treatment for AD; ...
Terent'ev Alexander O - - 2013
Phosphomolybdic acid (PMA) and phosphotungstic acid (PTA) efficiently catalyze the addition of H2O2 to β-diketones to form bridged 1,2,4,5-tetraoxanes. These reactions are not accompanied by the formation of monocyclic peroxides containing hydroxy and hydroperoxide groups or polymeric peroxides. The use of these catalysts made it possible to obtain bridged tetraoxanes ...
Pasternak Björn - - 2013
Ondansetron is frequently used to treat nausea and vomiting during pregnancy, but the safety of this drug for the fetus has not been well studied. We investigated the risk of adverse fetal outcomes associated with ondansetron administered during pregnancy. From a historical cohort of 608,385 pregnancies in Denmark, women who ...
Burrell Rebecca A RA Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, - - 2013
Cancer chromosomal instability (CIN) results in an increased rate of change of chromosome number and structure and generates intratumour heterogeneity. CIN is observed in most solid tumours and is associated with both poor prognosis and drug resistance. Understanding a mechanistic basis for CIN is therefore paramount. Here we find evidence ...
Halder A - - 2013
Dark-coloured semen is rarely observed in men with nonobstructive azoospermia in absence of genital tract bleeding. Dark-coloured semen is also observed rarely in men with spinal cord injury with or without genital tract bleeding. However, this condition has not been reported in the literature in absence of genital tract bleeding ...
Piechnik Agnieszka - - 2013
Angiogenesis has been shown to substantially contribute to the progression of chronic lymphocytic leukemia (CLL). Neuropilin-1 (NRP1) represents a receptor for VEGF, which has been reported to be overexpressed in several malignancies. In our study, we characterized mRNA levels of VEGF receptors including NRP1 in a large cohort of CLL ...
Gozen Oguz - - 2013
Nicotine is a highly addictive drug and exerts its effect partially through causing dopamine release, thereby increasing intrasynaptic dopamine levels in the brain reward systems. Dopaine D1 receptor (DRD1) mRNAs and receptors are localized in reward-related brain regions, which receive cholinergic input. The aim of this study is to evaluate ...
Zalewska Anna - - 2013
Abstract Objective. It should be expected that type 1 diabetes mellitus may disturb innate and acquired immunity. There are no data on type 1 diabetes mellitus-related changes in the salivary flow and the protein output responsible for the innate immunity of saliva depending on the quality of dentition reflecting the ...
Franić Tomislav - - 2013
AIMS: Suicidal ideation and sleep-related problems are associated with many common psychopathological entities in early adolescence. This study examined possible association between suicidal ideation and sleep-related problems. METHODS: A cross-sectional study was performed in classroom settings at 840 early adolescents 11-13 years of age. Of those, 791 adolescents fully completed ...
Saadeddin Anas - - 2013
Lactococcus lactis is modified to express a fibronectin fragment (FNIII7-10 ) as a membrane protein. This interphase, based on a living system, can be further exploited to provide spatio-temporal factors to direct cell function at the material interface. This approach establishes a new paradigm in biomaterial surface functionalization for biomedical ...
Cai Huanxin - - 2013
An effective, green, and facile approach to synthesize gold nanoparticle-loaded protein-polysaccharide nanogels was developed in this study. Biocompatible gold nanoparticle-loaded lysozyme-dextran (Au@Lys-Dex) nanogels were produced using lysozyme-dextran nanogels as reducing and stabilizing agents. Lysozyme-dextran nanogels have a size of about 200 nm and a structure of lysozyme core and dextran ...
Nagaoka Eiki - - 2013
Purpose: Postoperative atrial fibrillation (AF) is a common complication of cardiac surgery that is associated with an increased incidence of other complications. The goal of this prospective randomized study was to evaluate the effect of ultra-low dose landiolol hydrochloride for prevention of AF after off-pump coronary artery bypass grafting (CABG).Methods: ...
Löw Sabine S Justus-Liebig-Universität Gießen, Institut für Anorganische und Analytische Chemie, Heinrich-Buff-Ring 58, 35392 Gießen, - - 2013
Mixing CuCl2⋅2 H2O with benzylamine in alcoholic solutions led to an extremely colorful chemistry caused by the formation of a large number of different complexes. Many of these different species could be structurally characterized. These include relatively simple compounds such as [Cu(L(1))4Cl2] (L(1) = benzylamine) and (HL(1))2[CuCl4]. Most interestingly is the ...
Kumar S Nishanth - - 2013
The synergistic anticandidal activity of three diketopiperazines [cyclo-(L-Pro-L-Leu) (1), cyclo-(D-Pro-L-Leu) (2), and cyclo-(D-Pro-L-Tyr) (3)] purified from a Bacillus sp. N strain associated with entomopathogenic nematode Rhabditis (Oscheius) in combination with amphotericin B and clotrimazole was investigated using the macrodilution method. The minimum inhibitory concentration and minimum fungicidal concentration of the ...
Wang Yaxue - - 2013
Molecular dynamics (MD) simulations of three models based on the crystal structure of the E343K variant of human ferrochelatase were performed in this study. The "open" and "closed" conformations of the enzyme obtained by simulations are in agreement with the corresponding crystal structures. The snapshots and the structure analysis indicate ...
Martadinata Herry - - 2013
Telomeric-repeat containing RNAs (TERRA) are transcript products of the telomeres. Human TERRA sequences containing UUAGGG repeats can form parallel-stranded G-quadruplexes. The stacking interaction of such structures was shown to be important for ligand targeting and higher-order arrangement of G-quadruplexes in long TERRA sequences. Here we report on the first high-resolution ...
Korehei R - - 2013
AIMS: Antibacterial food packaging materials, such as bacteriophage-activated electrospun fibrous mats, may address concerns triggered by waves of bacterial food contamination. To address this, we investigated several efficient methods for incorporating T4 bacteriophage into electrospun fibrous mats. METHODS AND RESULTS: The incorporation of T4 bacteriophage using simple suspension electrospinning led ...
Gu Hongcheng - - 2013
Photonic crystal materials are developed from colloidal crystal fibers or beads. As the fibers have cylindrical symmetry, the fiber-composed PhCs show anisotropic angle independence. By contrast, the bead-composed PhCs display angle-independent structural colors because of the spherical symmetry of their bead elements.
Akter S - - 2013
SUMMARY Escherichia coli, a prominent waterborne pathogen, causes a variety of gastrointestinal and extraintestinal infections that depend on virulence determinants. To monitor natural aquatic systems for virulence-associated genes of E. coli, multiplex PCR was used in a survey covering 46 major natural water bodies in Bangladesh. DNA was extracted directly ...
Golan M - - 2013
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: The FEAHQ was originally developed in Israel and designed for use in family-based weight-management interventions that emphasized changes in the environment and in parents' knowledge, behaviors, and modeling. A key distinction of the FEAHQ from other tools is the ability to evaluate the ...
Krenn V - - 2013
The revised classification of the periprosthetic membrane (synovial-like interface membrane SLIM) encompasses all pathological alterations which can occur as a result of endoprosthetic replacement of major joints and lead to a reduction in durability of prostheses. This also includes the established consensus classification of SLIM by which aseptic and septic ...
Wang Fei - - 2013
Artificial leaf structures have been fabricated by the self-assembly of ZnO nanoparticles. A hydrothermal method was used to synthesize the nanoparticles. The self-assembly patterns showed asymmetric dendritic morphologies, larger surface-to-volume ratios, a broad absorption band and high resistance. A non-equilibrium two-stage-formation process included diffusion limited aggregation, and the phase-field model ...
Izumi Rumiko R Department of Medical Genetics, Tohoku University School of Medicine, Sendai, - - 2013
Myofibrillar myopathy (MFM) is a group of chronic muscular disorders that show the focal dissolution of myofibrils and accumulation of degradation products. The major genetic basis of MFMs is unknown. In 1993, our group reported a Japanese family with dominantly inherited cytoplasmic body myopathy, which is now included in MFM, ...
Cehreli Zafer C - - 2013
Abstract Objective. To compare the smear layer removal efficacy and erosive effects of different irrigation protocols under clinical and laboratory conditions. Materials and methods. Mandibular third molars (n = 32) of 30-45 year-old patients were instrumented with rotary files and were randomly assigned to one of the following groups for ...
Carracedo Arkaitz A CIC bioGUNE, Bizkaia Technology Park, Derio, Spain. - - 2013
Warburg suggested that the alterations in metabolism that he observed in cancer cells were due to the malfunction of mitochondria. In the past decade, we have revisited this idea and reached a better understanding of the 'metabolic switch' in cancer cells, including the intimate and causal relationship between cancer genes ...
Amama Placidus B - - 2013
A simple, reliable, and non-destructive approach based on contact angle measurements is described for predicting the activity of catalyst supports in carbon nanotube (CNT) carpet growth. The basic component of the surface free energy of different alumina supports - determined from the van Oss-Good-Chaudhury model and the Young-Dupré equation - ...
Brodin E - - 2013
Previous studies have provided indirect evidence for a possible association between vitamin D status and risk of venous thromboembolism (VTE). However, no study has so far investigated the association between serum levels of 25-hydroxyvitamin D (25(OH)D), the biomarker of vitamin D status, and risk of VTE. The aim of our ...
Fujisaki Momoko - - 2013
New Delhi metallo-β-lactamase-1 (NDM-1) is one of the metallo-β-lactamase (MBL), and has been identified from clinical isolates worldwide. The rapid detection of NDM-1 producers is necessary to prevent their dissemination. Seven kinds of metal- ethylenediaminetetraacetic acid (EDTA) complexes were evaluated as a metallo-β-lactamase (MBL) inhibitor for the double-disk synergy test ...
Singh Anshuman - - 2013
Oral administration of low doses (1.25 or 2.5 or 5 mg/kg) corresponding to 1/200th or 1/100th or 1/50th of LD50 of cypermethrin, a synthetic type II pyrethroid, to pregnant Wistar rats from gestation day 5 to 21 produced a dose-dependent increase in the expression of xenobiotic metabolizing cytochrome P450 (CYP) 1A-, ...
Yoshimura Noriko - - 2013
We herein report the case of a patient with an acute cervicomediastinal hematoma secondary to the spontaneous rupture of a parathyroid adenoma. A 47-year-old female presented with swelling and pain in the neck. She had no history of trauma or of having undergone any medical or odontological procedures. An ultrasound ...
Pendergraph Samuel A - - 2013
Free-standing colloidal arrays can be easily transferred to supported fibers. These films conform and provide the template to have consistent submicrometer and nanometer features transferred to the periphery of rough, 7 μm diameter fibers. This technique is adjustable to a number of fiber surfaces and colloidal template sizes.
Thivel D - - 2013
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: Acute exercise may lead to subsequent energy expenditure compensation. Intensive exercise may favor a higher compensation than low or moderate exercises. WHAT THIS STUDY ADDS: This post-exercise compensation might occur only in overweight/obese youth and not in lean. This work used objective measures ...
Zhu Jinbo - - 2013
Adopting fluorescence of PPIX enhanced by a split G-quadruplex and toehold mediated strand displacement reaction, a series of unlabeled fluorescent logic gates is set up and some of them are cascaded into circuits. Controlled release of PPIX, which is also a photosensitizer in photodynamic diagnosis and therapy, is realised by ...
Qi Hetong - - 2013
This study demonstrates a facile yet effective strategy for amperometric assay of electrochemically inactive heparin based on an anion-exchange mechanism with polyimidazolium (Pim) as the synthetic receptor. The rationale for the amperometric heparin assay is essentially based on the different binding affinity of the synthetic Pim receptor toward electrochemically active ...
Niu Dechao - - 2013
Multifunctional organic/inorganic hybrid nanovesicles, fabricated by a facile self-assembly/sol-gel approach, display a unique morphology (figure) and satisfactory stability under physiological conditions. By co-encapsulation of superparamagnetic magnetite nanoparticles and a liquid perfluorocarbon, the nanovesicles can be used not only as a dual-modality ultrasound/magnetic resonance contrast agent for accurate cancer diagnosis and ...
Fischer J - - 2013
Kallikrein-related peptidases (KLKs) constitute a family of 15 highly conserved serine proteases, which show a tissue-specific expression profile. This made them valuable tumour expression markers. It became evident that KLKs are involved in many physiological processes like semen liquefaction and skin desquamation. More recently, we have learnt that they are ...
Siddiqi Arjumand A Dalla Lana School of Public Health, University of Toronto, 155 College Street, Room 566, Toronto, ON M5T 3M7, Canada. - - 2013
We compare disparities in health status between first-generation immigrants and others in the United States (US) and Canada. We used data from the Joint Canada-US Survey of Health. The regression models adjusted for demographics, socioeconomic status, and health insurance (the US). In both countries, the health advantage belonged to immigrants. ...
Pol Diego - - 2013
Extant crocodylians have a limited taxonomic and ecological diversity but they belong to a lineage (Crocodylomorpha) that includes basal and rather generalized species and a highly diverse clade, Crocodyliformes. The latter was among the most successful groups of Mesozoic tetrapods, both in terms of taxonomic and ecological diversity. Crocodyliforms thrived ...
Jon McIlroy Simon S Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Aalborg, - - 2013
'Candidatus Microthrix parvicella' is a lipid-accumulating, filamentous bacterium so far found only in activated sludge wastewater treatment plants, where it is a common causative agent of sludge separation problems. Despite attracting considerable interest, its detailed physiology is still unclear. In this study, the genome of the RN1 strain was sequenced ...
Coyne Karin S - - 2013
Abstract Objective: The prevalence of non-steroidal anti-inflammatory drug (NSAID) and concurrent gastroprotective agent (GPA) use in the United States (US) is not known. As such, the prevalence of GPA use among arthritis patients taking NSAIDs was examined. Methods: Men and women age ≥40 with self-reported arthritis and members of a ...
Farghaly Thoraya A - - 2013
Synthesis of new derivatives of pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one via reaction of 7-(4-bromophenyl)-1,2-dihydro-5-(4-fluorophenyl)-2-thioxopyrido[2,3-d] pyrimidin-4(3H)-one with hydrazonoyl chlorides or reaction of 2-hydrazino-pyrido[2,3-d]pyrimidin-4(3H)-one with different aldehydes followed by cyclization of the products. All the newly synthesized compounds were evaluated for their antimicrobial activities and also their minimum inhibitory concentration against most of test organisms was ...
Buschke Nele - - 2013
The sustainable production of chemicals from renewable, non-food raw materials is one of the great challenges in industrial biotechnology. Corynebacterium glutamicum was metabolically engineered for the production of the bio-nylon precursor 1,5-diaminopentane from the hemicellulose sugar xylose. First, comparison of a basic diaminopentane producer on xylose and glucose revealed 30% ...
Yao Nengliang N Department of Health Policy and Administration, The Pennsylvania State University, 604 Ford Building, University Park, PA 16802, USA. - - 2013
To examine the relationship between radiation therapy resources and guideline-concordant radiotherapy after breast-conserving surgery (BCS) in Kentucky. The SEER registry and Area Resource File provided county-level data describing cancer care resources and socioeconomic conditions of Kentucky residents. The outcome variable was rate of BCS without radiotherapy in each county for ...
Alexiev Borislav A - - 2013
Erdheim-Chester disease (ECD) is a rare, non-Langerhans form of histiocytosis of unknown origin with distinct clinicopathologic and radiographic features. Reports detailing the cytology of ECD are rare. We describe a case of ECD with pericardial effusion. Cytologic examination revealed a hypercellular specimen composed of clusters and singly dispersed foamy macrophages ...
Haag Wendell R - - 2013
Selection is expected to optimize reproductive investment resulting in characteristic trade-offs among traits such as brood size, offspring size, somatic maintenance, and lifespan; relative patterns of energy allocation to these functions are important in defining life-history strategies. Freshwater mussels are a diverse and imperiled component of aquatic ecosystems, but little ...
Hou Ningqi - - 2013
Recent reports have shown that the breast cancer incidence rate in the US stabilized after a sharp reduction in 2002 and 2003. It is important to continue monitoring breast cancer incidence rates according to age group, race/ethnicity, estrogen receptor (ER) status, and tumor stage. Age-standardized breast cancer incidence rates were ...
Debeer Elise - - 2013
Functional avoidance is considered as one of the key mechanisms underlying overgeneral autobiographical memory (OGM). According to this view OGM is regarded as a learned cognitive avoidance strategy, based on principles of operant conditioning; i.e., individuals learn to avoid the emotionally painful consequences associated with the retrieval of specific negative ...
Baker Joseph - - 2013
Over the past decade a small evidence base has highlighted the potential importance of seemingly innocuous variables related to one's hands, such as hand dominance and the relative length of the second and fourth digits (2D:4D ratio), to success in sport. This study compared 2D:4D digit ratio and handedness among ...
Khan Gulfaraz - - 2013
In September 2012, a novel coronavirus was isolated from a patient in Saudi Arabia who had died of an acute respiratory illness and renal failure. The clinical presentation was reminiscent of the outbreak caused by the SARS-coronavirus (SARS-CoV) exactly ten years ago that resulted in over 8000 cases. Sequence analysis ...
Corazzini Kirsten N - - 2013
Inadequate pain medication management is pervasive in nursing homes (NHs). Licensed practical nurses (LPNs) deliver the majority of licensed nursing care, but LPNs are neither trained nor licensed to provide comprehensive pain assessment and medication management. In this study, we describe how pain medication management occurs in NHs by exploring ...
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