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- - 2013
On June 24, 2012, CDC notified Public Health Services, County of San Diego Health and Human Services Agency, of a suspected case of vaccinia virus infection transmitted by sexual contact. The case had been reported to CDC by an infectious disease specialist who had requested vaccinia immune globulin intravenous (VIGIV) ...
van Akkooi A C J - - 2013
ORIGINAL ARTICLE: Hauschild A, Grob JJ, Demidov LV et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 2012; 380: 358-65. Background  Dabrafenib, an inhibitor of mutated BRAF, has clinical activity with a manageable safety profile in phase I and II studies in patients with ...
Sasaki Muneteru - - 2013
Intermittent administration of parathyroid hormone, PTH, appears to promote preosteoblastic proliferation and osteoblastic bone formation, giving rise to anabolic effect in bone. We investigated the behavior of osteoblastic cells after intermittent PTH treatment and attempted to elucidate the role of osteoclasts on the mediation of PTH-driven bone anabolism. As a ...
Selander Jodi - - 2013
Maternal placentophagy, although widespread among mammals, is conspicuously absent among humans cross-culturally. Recently, however, advocates for the practice have claimed it provides human postpartum benefits. Despite increasing awareness about placentophagy, no systematic research has investigated the motivations or perceived effects of practitioners. We surveyed 189 females who had ingested their ...
Schreier Stefan - - 2013
Leptospirosis is re-emerging as a worldwide zoonosis and is caused by bacteria of the genus Leptospira. Human leptospirosis is associated with high temperature and humidity. Laboratory tests are indispensible for the early diagnosis and proper disease management. The demand for suitable leptospirosis point-of-care diagnostic tests grows with the awareness and ...
Leblanc Francis R - - 2013
Evaluation of: Mishra A, Liu S, Sams GH et al. Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation. Cancer Cell 22(5), 645-655 (2012). There is increasing evidence identifying a link between inflammation and cancer. A potent proinflammatory cytokine, IL-15, stimulates the proliferation and ...
Marchand-Libouban H - - 2013
Objectives: Molecular events occurring in the bone marrow microenvironment of an immobilized mouse limb after Botulinum toxin (BTX) injection haven't been characterized. BTX injection induces a localized disuse in which the tissue events have well been characterized. Methods: BTX injection was performed in the right quadriceps; saline injection in the ...
Marutsuka Takashi - - 2013
A 62-year-old man, with chronic renal failure and receiving hemodialysis, pointed out to have an abnormal shadow on a chest X-ray. A chest computed tomography (CT), magnetic resonance imaging (MRI), and fluorodeoxyglucose-positron emission tomography (FDG-PET) examination showed a 6 cm size mass lesion in the middle of left thoracic cavity. ...
Müller Andreas - - 2013
Abstract The analysis of effects from coupling in and between systems is important in data-driven investigations as practiced in many scientific fields. It allows deeper insights into the mechanisms of interaction emerging among individual smaller systems when forming complex systems as in the human circulatory system. For systems featuring various ...
Pfefferkorn Blanche - - 2013
Editor's note: From its first issue in 1900 through to the present day, AJN has unparalleled archives detailing nurses' work and lives over the last century. These articles not only chronicle nursing's growth as a profession within the context of the events of the day, but they also reveal prevailing ...
Dephoure Noah - - 2013
A mechanistic understanding of signaling networks requires identification and analysis of phosphorylation sites. Mass spectrometry offers a rapid and highly sensitive approach to mapping phosphorylation sites. However, mass spectrometry has significant limitations that must be considered when planning to carry out phosphorylation-site mapping. Here we provide an overview of key ...
Fukada Yasuhisa - - 2013
A 77-year-old man who had undergone left pneumonectomy 16 years and quadruple coronary artery bypass grafting (CABG) 4 years previously presented with unstable angina pectoris. Coronary angiography revealed severe stenosis of the left main trunk and the proximal left anterior descending artery(LAD), and the severely narrowed left internal thoracic artery ...
Singh Nivedita - - 2013
Biosurfactant produced from Pseudomonas aeruginosa DSVP20 was evaluated for its potential to disrupt Candida albicans biofilm formed on polystyrene (PS) surfaces in this investigation. P. aeruginosa DSVP20 exhibited optimum production of biosurfactant (5.8 g L-1) after 96 h of growth with an ability to reduce surface tension of the aqueous solution from 72 ...
Magli Adriano - - 2013
PURPOSE: To assess the long-term outcomes and complications of patients with uveitis from juvenile idiopathic arthritis (JIA) treated with adalimumab. METHODS: Prospective interventional case series. All patients who underwent treatment with adalimumab for JIA and anterior uveitis were prospectively included in the study. The anterior chamber inflammation was evaluated according ...
Scialla Julia J - - 2013
Previously, recipients of a simultaneous pancreas-kidney transplant versus a kidney transplant alone were thought to have higher fracture risk. Using a large US registry, Nikkel et al. observed lower rates of fracture hospitalization among patients with type 1 diabetes after simultaneous pancreas-kidney compared with kidney transplantation alone, particularly among men. ...
Jain Archana - - 2013
A focused review of the risk of harms of anti-TNF inhibitors in adult rheumatic diseases was performed. An increased risk of serious infections, tuberculosis and other opportunistic infections has been reported across various studies, with etanercept appearing to have a modestly better safety profile in terms of tuberculosis and opportunistic ...
Ferguson J S - - 2013
Podoconiosis is a common cause of lymphoedema in barefoot workers in Ethiopia and other countries. It has severe consequences for patients' physical function, quality of life and economic status. To investigate stratum corneum (SC) hydration and transepidermal water loss (TEWL) in patients with podoconiosis compared with controls. In total, 55 ...
Seth Jai H JH Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, London, UK. - - 2013
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: The search for a biomarker in overactive bladder syndrome (OAB) is an emerging field of interest, as bladder dysfunction is a common complaint that causes significant morbidity. A biomarker may give us insight as a diagnostic tool, and also ...
Rosenberg Laura L Center for Inflammatory Bowel Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, - - 2013
Patients with ulcerative colitis (UC) who are in clinical remission may still have underlying endoscopic inflammation, which is associated with inferior clinical outcomes. The goal of this study was to determine the prevalence of active endoscopic disease, and factors associated with it, in patients with UC who are in clinical ...
Di Domizio Jeremy J Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, - - 2013
In recent years, active research using genomic, cellular and animal modeling approaches has revealed the fundamental forces driving the development of autoimmune diseases. Type I interferon imprints unique molecular signatures in a list of autoimmune diseases. Interferon is induced by diverse nucleic acid-containing complexes, which trigger innate immune activation of ...
Yin Vivian T VT Section of Ophthalmology, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, - - 2013
To review the literature on targeted therapy for orbital and periocular basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC) and provide examples of patients recently treated with such therapy. The authors reviewed the literature on clinical results of targeted therapy and the molecular basis for targeted therapy in ...
Ball Carissa J CJ Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, - - 2013
Reperfusion following ischemia leads to neutrophil recruitment into injured tissue. Selectins and β2-integrins regulate neutrophil interaction with the endothelium during neutrophil rolling and firm adhesion. Excessive neutrophil infiltration into tissue is thought to contribute to ischemia-reperfusion injury damage. Hydrogen sulfide mitigates the damage caused by ischemia-reperfusion injury. This study's objective ...
Li J J Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical - - 2013
Methods are needed for quantifying muscle deconditioning due to immobilization, aging, or spaceflight. Electrical impedance myography (EIM) is one technique that may offer easy-to-follow metrics. Here, we evaluate the time course and character of the change in single- and multi-frequency EIM parameters in the hind-limb suspension model of muscle deconditioning ...
Koga Takaaki T Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, - - 2013
The haematoma at a fracture site plays an important role in fracture healing. Previously, we demonstrated that a fracture haematoma contains multilineage mesenchymal progenitor cells. We postulated that the haematoma provided a source of chondrogenic cells for endochondral ossification during fracture healing and preservation of the cells contributed to biological ...
Li Guo - - 2013
Compared with single-focus optical-resolution photoacoustic microscopy (OR-PAM), multifocal OR-PAM utilizes both multifocal optical illumination and an ultrasonic array transducer, significantly increasing the imaging speed. A reflection-mode multifocal OR-PAM system based on a microlens array that provides multiple foci as well as an ultrasonic array transducer that receives the excited photoacoustic ...
Turel Mazda K MK Section of Neurosurgery, Department of Neurological Sciences, Christian Medical College, Vellore 632 004, Tamil Nadu, India. - - 2013
To determine whether motion preservation following oblique cervical corpectomy (OCC) for cervical spondylotic myelopathy (CSM) persists with serial follow-up. We included 28 patients with preoperative and at least two serial follow-up neutral and dynamic cervical spine radiographs who underwent OCC for CSM. Patients with an ossified posterior longitudinal ligament (OPLL) ...
Hesemann Jennifer J University of Wisconsin-Madison, Madison, WI 53705, - - 2013
A retrospective medical record review of cases with congenital vertebral malformations (CVMs) and controls with normal spine morphology. To determine the relative contribution of maternal environmental factors (MEFs) during pregnancy to CVM development. CVMs represent defects in formation and segmentation of somites occurring with an estimated incidence of between 0.13 ...
Lennon E M EM Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27607, - - 2013
It has become increasingly evident that disease flares in the human inflammatory bowel diseases are influenced by life stress. It is known that life stress can trigger disturbances in intestinal barrier function and activate proinflammatory signaling pathways, which are important contributors to intestinal inflammation and clinical disease; however, the exact ...
Rocha Karolinne Maia KM Cleveland Clinic Foundation, Cleveland, OH, USA. - - 2013
To assess corneal microarchitecture and regional epithelial thickness profile in eyes with keratoconus, postoperative corneal ectasia (ectasia), and normal unoperated eyes (controls) using spectral-domain optical coherence tomography (SD-OCT). Regional corneal epithelial thickness profiles were measured with anterior segment SD-OCT (Optovue RTVue-100, Optovue Inc., Fremont, CA). Epithelial thickness was assessed at ...
Cahoon Neil J NJ Research Institute, The Hospital for Sick Children, Toronto, Ontario, - - 2013
In autogenous muscle transplantation, unpredictable complications can cause prolonged ischemia, resulting in ischemia-reperfusion injury. The authors investigated the efficacy and mechanism of nicorandil, a nitrovasodilator and adenosine triphosphate-sensitive potassium channel opener, in inducing perioperative protection of muscle flaps from ischemia-reperfusion injury. Pigs (18.2 ± 2.4 kg) were assigned to one ...
Furukawa Matakazu M Department of Radiology, Yamaguchi University, Yamaguchi, Japan. - - 2013
Preoperative knowledge of a patient's individual variations in facial artery anatomy would benefit plastic surgeons for reconstructive planning. The authors evaluated the feasibility of multislice computed tomographic angiography in vascular mapping of the facial artery. In total, 187 facial arteries in 94 patients without facial tumor or vascular disease were ...
Bastidas Nicholas N Hospital of University of Pennsylvania, Philadelphia, PA, USA. - - 2013
Composite facial allografts have become increasingly popular in the reconstruction of complex facial defects. Good to excellent aesthetic results can be achieved, particularly when a foundation of donor skeleton has been transferred. The authors propose using a conventional craniofacial technique (monobloc osteotomy) to transfer a thin monocortical foundation of bone, ...
Nie Jing-Ying JY Department of Hand Surgery, First Affiliated Hospital of Jilin University, Jilin, - - 2013
The anatomy of any particular vascular perforator relative to its vascular territory (perforasome) and flow characteristics is unique and complex. This arterial perforasome study with laboratory rabbits was conducted to assess four-dimensional computed tomographic angiography as an imaging tool for the design of individualized tissue transfers. This study offers clinically ...
Sears Erika Davis ED Section of Plastic Surgery, Department of Surgery, University of Michigan Health System, 1500 East Medical Center Drive, 2130 Taubman Center, SPC 5340, Ann Arbor, MI 48109-5340, - - 2013
The authors' aim was to conduct a national survey of hand surgery fellowship program directors to determine differences of opinions of essential components of hand surgery training between program directors from plastic and orthopedic surgery programs. The authors performed a Web-based survey of 74 program directors from all Accreditation Council ...
Eberlin Kyle R KR Division of Plastic Surgery, Massachusetts General Hospital, 55 Fruit Street, WACC 435, Boston, MA 02114, USA. - - 2013
Academic institutions receive many patients transferred specifically for hand surgery evaluation. The purpose of this study was to evaluate the demographics and insurance status of patients transferred for this reason. A retrospective review was performed of 155 transferred and 1017 nontransferred patients with a primary hand diagnosis during 3 summer ...
Deleyiannis Frederic W-B FW Department of Pediatric Plastic Surgery, Children's Hospital Colorado, 13123 East 16th Avenue, B467, Aurora, CO 80045, USA. - - 2013
The purpose of this study was to determine the financial impact of cleft care on the hospital and to evaluate trends in reimbursement over the past 6 years. Medical and accounting records of 327 consecutive infants undergoing cleft repair between 2005 and 2011 were reviewed. Charges, payments, and direct cost ...
Guimarães Paulo Afonso Monteiro Pacheco PA Division of Plastic Surgery, Universidade Federal de São Paulo, Rua Napoleão de Barros 715, 4o. andar, CEP 04024-002 São Paulo, Brazil. - - 2013
Stretch marks, or striae distensae, are dermal scars and result in considerable aesthetic concern. The responsible factors for their development are poorly understood. Development of striae distensae is a rare complication after breast augmentation. Successfully treating striae distensae has always been challenging. Lasers and light devices have recently become a ...
Costa-Ferreira António A Department of Plastic Surgery, São João Hospital, Porto Medical School, Porto, - - 2013
Scarpa fascia preservation has been suggested as a way of reducing complications associated with conventional abdominoplasty. A prospective randomized study was conducted to evaluate the effect on results and complications of preserving the Scarpa fascia during a full abdominoplasty. This was a single-center study conducted from August of 2009 to ...
Ono Shimpei S Department of Plastic, Reconstructive, and Aesthetic Surgery, Nippon Medical School, Tokyo, - - 2013
In the clinical decision-making process, prognostic information gives physicians guidance regarding disease and treatment that can be passed along to patients. Using the clinical scenario of a type IIIB open tibial fracture as an example, this article focuses on how to search prognostic literature effectively and how to critically appraise ...
Cemal Yeliz Y Plastic and Reconstructive Surgical Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, - - 2013
The aims of the current study were to (1) measure trends in the type of mastectomy performed, (2) evaluate sociodemographic/hospital characteristics of patients undergoing contralateral prophylactic mastectomy versus unilateral mastectomies, and (3) analyze reconstruction rates and method used following different mastectomy types. Mastectomies from 1998 to 2008 were analyzed using ...
Enjo Mitsuhiro M Department of Plastic and Reconstructive Surgery, Kinki University Faculty of Medicine, Osaka, - - 2013
Approaches to auricular reconstruction have shown improved outcome when a basic fibroblast growth factor (bFGF) slow-release system and fibrin spraying are combined with biodegradable polymers. More complex, three-dimensional structures, such as those that replicate the human auricle, are often lost because of biodegradation of the synthetic scaffold. To improve the ...
Chmielewski Lauren L Department of Plastic Surgery, University Hospitals Case Medical Center, and Case Western Reserve University School of Medicine, Cleveland, OH, - - 2013
This study was designed to compare the success of occipital migraine headache surgery with and without occipital artery ligation. The medical charts of 170 occipital migraine headache surgery recipients who fulfilled the study criteria were reviewed. Patients were divided into either the occipital artery resection group (one or both occipital ...
Sananpanich Kanit K Department of Orthopedics, Chiang Mai University, Chiang Mai 50200, Thailand. - - 2013
With increasing use of free vascular flaps of the saphenous artery and descending genicular artery, the authors investigated the anatomical variations in cadavers. Thirty-one fresh cadaveric thighs were studied by anatomical dissection. The perforators and their source arteries were skeletonized along their courses to the superficial femoral artery and measured. ...
Martin-Smith James D JD Department of Plastic and Reconstructive Surgery, St. James's Hospital, James's Street, Dublin 8, Ireland. - - 2013
Cleft palate fistulas of the anterior hard palate following previous repair are a challenging surgical problem. In addition to nasal regurgitation and potential adverse effects on speech, these fistulas may necessitate obturation with a removable dental prosthesis and can mitigate a fixed prosthodontic dental reconstruction. The authors present a method ...
Guyuron Bahman B Department of Plastic Surgery, Case Western Reserve University, 29017 Cedar Road, Cleveland, Ohio 44124, USA. - - 2013
Frontal bossing is a displeasing prominence of the supraorbital area. Aesthetic correction has been described as an open surgical technique. This report introduces an endoscopic approach to correction. A retrospective review was performed on all patients who underwent endoscopic repair of frontal bossing from 2002 to 2009. Demographics, intraoperative and ...
Maijers Maria C MC Department of Surgical Oncology, Erasmus Medical Center/Daniel den Hoed Cancer Center, Amsterdam, the - - 2013
Recently, Poly Implant Prothèse silicone breast implants were recalled from the European market. The authors studied 112 women and previously published data on rupture prevalence. Women are presenting with symptoms they feel may be a result of ruptured implants. The authors' aim was to study the clinical consequences of Poly ...
Neaman Keith C KC Grand Rapids Medical Education and Research Center and College of Human Medicine, Michigan State University, Grand Rapids, MI, - - 2013
Abdominoplasty is one of the most commonly performed cosmetic operative procedures. Few large studies have examined outcomes of cosmetic abdominoplasty in a community setting. The authors explored postoperative outcome and the preoperative and intraoperative factors that may contribute to these complications. A retrospective review of consecutive patients undergoing abdominoplasty over ...
Wei Fu-Chan FC Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University Medical College, 5 Fu-Shing Street, Taoyuan, Taiwan. - - 2013
Orbitomaxillary, skull, scalp, and hair restoration covers a broad segment of reconstructive surgery. The purpose of this article is to review considerations in available options for reconstruction, flap selection, relevant anatomy, and potential hazards. Although there are a variety of methods available to treat these complex defects, core principles are ...
Gosain Arun K AK Division of Plastic Surgery, Lurie Children's Hospital of Northwestern University, 225 East Chicago Avenue, Box 93, Chicago, IL 60611, USA. - - 2013
This study compared the practice profiles of plastic surgeons applying for recertification/maintenance of certification with those applying for primary certification by the American Board of Plastic Surgery between 2003 and 2011. American Board of Plastic Surgery case logs from both recertification and primary certification candidates from 2003 to 2011 were ...
Khansa Ibrahim I Department of Plastic Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, - - 2013
Fat necrosis is a common and potentially exasperating complication of autologous breast reconstruction. The authors performed a systematic review of the English literature on autologous breast reconstruction to determine significant patient and surgical factors that are predictors of postoperative fat necrosis. A PubMed search using the terms "fat necrosis" and ...
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