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Suzuki Yuta Y Department of Chemistry, Materials Science and Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United - - 2013
In the commonly used nucleation-dependent model of protein aggregation, aggregation proceeds only after a lag phase in which the concentration of energetically unfavorable nuclei reaches a critical value. The formation of oligomeric species prior to aggregation can be difficult to detect by current spectroscopic techniques. By using real-time (19)F NMR ...
Sarkar Sourav S Department of Chemistry, The University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606, - - 2013
MUC1 variable number tandem repeats (VNTRs) conjugated to tumor-associated carbohydrate antigens (TACAs) have been shown to break self-tolerance in humanized MUC1 transgenic mice. Therefore, we hypothesize that a MUC1 VNTR TACA-conjugate can be successfully formulated into a liposome-based anticancer vaccine. The immunogenicity of the vaccine should be further augmented by ...
Picken Maria M - - 2013
Among the various systemic amyloidoses, deposits derived from the immunoglobulin light chain (AL) account for 85% of cases. In this issue, Nasr et al. report 16 cases of renal heavy and light+heavy chain amyloidosis and compare them with renal light chain amyloidosis. While additional studies are needed to shed light ...
Guan Zheng-Jun - - 2013
Transgenic plant-derived vaccines comprise a new type of bioreactor that combines plant genetic engineering technology with an organism's immunological response. This combination can be considered as a bioreactor that is produced by introducing foreign genes into plants that elicit special immunogenicity when introduced into animals or human beings. In comparison ...
Turel Mazda K - - 2013
PURPOSE: To determine whether motion preservation following oblique cervical corpectomy (OCC) for cervical spondylotic myelopathy (CSM) persists with serial follow-up. METHODS: We included 28 patients with preoperative and at least two serial follow-up neutral and dynamic cervical spine radiographs who underwent OCC for CSM. Patients with an ossified posterior longitudinal ...
Wallis Laura - - 2013
Recognition by reimbursement and insurance companies remain key issues.
Takahashi Shunji - - 2013
Bone metabolic markers consist of bone formation markers, which are secreted from osteoblasts (BAP, OC, P1CP, P1NP) , and bone resorption markers, which are metabolites of bone type 1 collagen or secreted from osteoclasts (PYD, DPD, NTX, CTX, 1CTP, TRACP) . Those bone metabolic markers are useful for : (1) ...
Adinolfi Luigi E - - 2013
Steatosis is a complication of hepatitis C virus (HCV) infection and the mechanisms of its development are complex, involving viral and host factors. Steatosis that is prevalently viral is associated with HCV genotype 3, and steatosis that is prevalently metabolic is associated with non-3 genotypes. Viral steatosis is correlated with ...
Morse C I - - 2013
The aim of this investigation was to determine the effect of sustained monophasic oral contraceptive pill (MOCP) use on the in vivo passive stiffness of the gastrocnemius medialis (GM) muscle-tendon unit. Twenty four females volunteered for this study (age range 20-25 yrs); twelve participants had been taking the combined MOCP ...
Koytak Arif - - 2013
To describe a technique for the fixation of intraocular lenses or capsular tension rings through the ciliary sulcus or pars plana. This alternative technique allows burial of the knot and the free suture ends within the sclera, without using a scleral flap or pocket or even a conjunctival opening. No ...
Kubo Hidefumi - - 2013
We report a case of solitary ectopic thymoma at the ligamentum arteriosum, which was resected with thoracoscopic surgery. A 62-year-old male patient received chemoradiation therapy for laryngeal cancer approximately 1 year before. The present computed tomography scan indicated a mass (diameter, 2 cm) at the ligamentum arteriosum. Furthermore, positron emission ...
Bastidas Nicholas - - 2013
: Composite facial allografts have become increasingly popular in the reconstruction of complex facial defects. Good to excellent aesthetic results can be achieved, particularly when a foundation of donor skeleton has been transferred. The authors propose using a conventional craniofacial technique (monobloc osteotomy) to transfer a thin monocortical foundation of ...
Harada Atsushi - - 2013
DXA can accurately calculate bone mass, fat mass, and lean body mass, and so is considered the gold standard among methods of measuring skeletal muscle mass. Skeletal muscle mass is an essential item in the diagnosis of sarcopenia. Since the appendicular lean mass nearly corresponds to muscle mass, the appendicular ...
Dilbone Megan - - 2013
Lodgepole pine (Pinus contorta var. latifolia) is a tree species utilized for succulent edible cambium and secondary phloem in the spring by Interior First Peoples of the Pacific Northwest. In this article we present a nutritional analysis of this food based on a pooled sample of 17 trees harvested in ...
Christen Urs - - 2013
Antibodies play an important role in autoimmune liver diseases, such as autoimmune hepatitis (AIH). On the one hand, they are essential diagnostic markers to identify not only the presentation of AIH, but also the AIH subtype characterized by the presence of particular antibodies to target autoantigens in the liver. On ...
Palmer-Powell Jacqueline - - 2013
This column explores the development and implementation of a cardiac catheterization laboratory nursing fellowship at a 600-bed, tertiary-care hospital that is part of a large, multi-facility health system.
Frings-Meuthen P - - 2013
Objectives: Wnt signaling pathway may be crucial in the pathogenesis of disuse-induced bone loss. Sclerostin and DKK1, antagonists of the Wnt signaling pathway, were assessed during immobilization by bed rest in young, healthy people. Methods: Two bed rest studies were conducted at the German Aerospace Center in Cologne. 14 days ...
Thomas Bettina C - - 2013
To analyze the refractive outcomes and safety of three-piece silicone toric sulcus-fixated add-on intraocular lenses (IOLs) (HumanOptics/Dr.Schmidt Intraocularlinsen, Erlangen, Germany) in complex clinical cases with high astigmatism such as in cases with previous penetrating keratoplasty. Interventional case series of 21 eyes of 20 patients enrolled at two German centers. Functional ...
Kondo Taichi - - 2013
We report a case of acute type A dissection with acute abdomen due to blood flow insufficiency in the superior mesenteric artery. A 73-year-old man was presented to hospital complaining sudden onset of chest pain. Contrast-enhanced computed tomography revealed a type A aortic dissection, that extendedfrom the ascending aorta to ...
Cahoon Neil J - - 2013
: In autogenous muscle transplantation, unpredictable complications can cause prolonged ischemia, resulting in ischemia-reperfusion injury. The authors investigated the efficacy and mechanism of nicorandil, a nitrovasodilator and adenosine triphosphate-sensitive potassium channel opener, in inducing perioperative protection of muscle flaps from ischemia-reperfusion injury. : Pigs (18.2 ± 2.4 kg) were assigned ...
Sananpanich Kanit - - 2013
: With increasing use of free vascular flaps of the saphenous artery and descending genicular artery, the authors investigated the anatomical variations in cadavers. : Thirty-one fresh cadaveric thighs were studied by anatomical dissection. The perforators and their source arteries were skeletonized along their courses to the superficial femoral artery ...
Shek Daniel T L - - 2013
Abstract A total of 236 schools participated in the Project P.A.T.H.S. in the 2010/2011 school year. After completion of the Tier 1 Program, subjective outcome evaluation data were collected from 3275 program implementers. Based on the consolidated findings based on schools as units, results showed that participants had positive perceptions ...
Stone John H - - 2013
Alexander et al. give a detailed description of IgG4-related membranous glomerulonephritis (MGN). Their data delineate for the first time in IgG4-related disease (IgG4-RD) a second pattern of tissue injury occurring within the same organ. The paper highlights that MGN can occur alone or simultaneously with IgG4-related tubulointerstitial nephritis. Thus, it ...
Wei Fu-Chan - - 2013
LEARNING OBJECTIVES:: After reading this article, the participant should be able to: 1. Discuss the options for reconstruction of scalp, skull, orbit, and maxilla defects. 2. Describe the core principles to obtaining a sound result. SUMMARY:: Orbitomaxillary, skull, scalp, and hair restoration covers a broad segment of reconstructive surgery. The ...
Kawabe Joji - - 2013
Tc-hydroxymethylene diphosphonate is not directly to Calcium of the bone matrix, but is binding to hydroxyapatite within the bone matrix. Strontium-89 is a member of family II A of the periodic table, same as Calcium, and is incorporated into bone matrix directly. It is very important that the the regions ...
Weidauer L A - - 2013
Objectives: The purpose of this study was to determine variability in cortical volumetric bone density (vBMD) from a single slice tibia image over a range of vBMD readings and ages. Methods: Males and females (N=80; aged 6-80) were randomly selected from a previous study. Cortical vBMD at the anterior, posterior, ...
Javaloy Jaime - - 2013
To investigate the effect of topical eye application of platelet-rich plasma (E-PRP) on the recovery of corneal sensitivity after LASIK and the anatomical recovery of the sub-basal corneal plexus as studied by confocal microscopy. This was a randomized, consecutive, controlled, prospective and masked study on 108 myopic eyes receiving LASIK. ...
Hirooka Shigeki - - 2013
A 71-year-old man was admitted with complaints of high fever and lumbago. Echocardiography showed vegetation about 16×7 mm in size attached to the tricuspid valve. Magnetic resonance imaging showed osteomyelitis. As serial echocardiography showed the progression of valvular lesion despite antibiotic therapy, the patient underwent endoscopic removal of intervertebral disc ...
Furukawa Matakazu - - 2013
: Preoperative knowledge of a patient's individual variations in facial artery anatomy would benefit plastic surgeons for reconstructive planning. The authors evaluated the feasibility of multislice computed tomographic angiography in vascular mapping of the facial artery. : In total, 187 facial arteries in 94 patients without facial tumor or vascular ...
Yamazaki Kaoru - - 2013
Previous studies have demonstrated close associations between QUS parameters and osteoporotic status. However, due to the ambiguities in assessing accuracy of QUS and the moderate correlation of DXA and QUS results, currently there is no agreement on how results of QUS devices should be interpreted in order to diagnose osteoporosis. ...
Bicho Natalina Cavaco - - 2013
Roasted coffee samples of the two major trade species (Coffea arabica and C. canephora) were studied to identify sensory descriptors that might be used to determine blends production and evaluation, following the expectations of consumers. Coffee beans were roasted at 220 + 10 °C, for 7, 9, and 11 min, ...
Stolzenberg N - - 2013
Objectives: In order to better understand which training approaches are more effective for preventing bone loss in post-menopausal women with low bone mass, we examined the effect of a nine-month resistive exercise program with either an additional whole body vibration exercise (VIB) or balance training (BAL). Methods: 68 post-menopausal women ...
Lim Dong Hui - - 2013
To identify factors that influence near vision after monofocal intraocular lens (IOL) implantation for distance vision. A retrospective review was conducted of patients who underwent cataract surgery with monofocal IOL implantation from October 2009 to April 2010 at Samsung Medical Center. Eyes were classified as having good (⩾ J4) or ...
Sato Hirotaka - - 2013
We report a case of isolated, unruptured extracardiac aneurysm of the right coronary sinus of Valsalva. The aneurysm was detected incidentally in a 75-years-old woman during the treatment of angina pectoris. A 30×35 mm sized aneurysm was located in the right sinus of Valsalva with extracardiac protrusion. It was repaired ...
Zhang Xiuyan - - 2013
In order to display malolactic enzyme (MLE) on the cell surface of Saccharomyces cerevisiae, a yeast cell surface display plasmid pADH1-AGG was constructed by fusing the α-factor signal encoding sequence (267 bp) and the C-terminal half of α-agglutinin encoding sequence (1,645 bp) into the plasmid pADH1. The pADH1-AGG could successfully express and ...
Kumar Yashwant - - 2013
Allergic disorders are a group of immune-mediated disorders that are associated with considerable morbidity and ill health. There has been significant rise in the prevalence of allergy in the last few years. This has heightened interest in uncovering the novel mechanisms involved in etiopathogenesis of allergic disorders. Understanding the pathways ...
Niino Tetsuya - - 2013
Ventricular septal perforation is one of the most serious complications of acute myocardial infarction, and is often fatal unless treated surgically. Despite the development of various surgical techniques for repair of postinfarction ventricular septal perforation, the operative mortality remains high. We report 3 consecutive cases in which a modified infarct ...
Avitia Roberto L - - 2013
Abstract Ventricular late potentials (VLPs) are small-amplitude waves with a short duration that appear at the end part of the QRS complex, making a QRS complex duration larger. The signal-averaged electrocardiography (ECG) technique enhances VLPs and beats, assuming noise as the only random variable. However, ECG signals are not completely ...
Haulon Stéphan - - 2013
Until fairly recently, experience with advanced endovascular technologies, including fenestrated endovascular repair (FEVAR), has been limited to a relatively small number of practitioners worldwide. Excellent outcomes have been achieved by these accomplished surgeons who, at least initially, have primarily used custom-made devices constructed by a single endograft manufacturer. Access to ...
Shek Daniel T L - - 2013
Abstract To help university teachers to understand Service-Learning and develop Service-Learning subjects, a 3-h+ e-learning package was developed at The Hong Kong Polytechnic University (PolyU). There are seven units in this e-learning package: introduction session (Unit 1), what is Service-Learning? (Unit 2), impact and benefits of Service-Learning (Unit 3), myths ...
Tamaki Shuji - - 2013
We address the left atrial posterior wall flap (LAPF) method for the isolated total anomalous pulmonary venous drainage( TAPVD) II a. The postoperative pulmonary venous obstruction( PVO) is a serious complication and is not rare after repair of the isolated TAPVD II a by the conventional surgical techniques. The LAPF ...
Shek Daniel T L - - 2013
Abstract The purpose of this study is to examine the relationships between economic disadvantage and adolescent and developmental outcomes as well as perceived family qualities in 3580 Secondary 2 students in Hong Kong. Developmental outcomes include positive youth development constructs, problem behavior and drug taking behavior, whereas perceived family qualities ...
Collins Amy M - - 2013
Early intervention through parents is key to improving child behavior outcomes.
Hynes Sally - - 2013
: Lip hemangiomas have traditionally been approached with expectant management. However, intervention is warranted for associated complications, including facial disfigurement, feeding difficulties, speech impairment, and psychosocial manifestations. The authors evaluated outcomes of complicated lip hemangiomas resected during the proliferative as compared with the involutional phase. : A retrospective review of ...
Biskup E - - 2013
Background  We have previously discovered that Notch1 is expressed on malignant T cells in cutaneous T-cell lymphoma (CTCL), and is required for survival of CTCL cell lines. Notch can be inhibited by γ-secretase inhibitors (GSIs), which differ widely in their ability to induce apoptosis in CTCL. Objectives  To investigate whether ...
Mori Satoshi - - 2013
Atypical fractures of femoral shaft and pelvis occurred on the long-term bisphosphonate treatment patients have been first reported in 2005. Since then many cases have been reported, while the number of atypical fractures is small compared with that of bisphosphonate treatment patients. It is speculated that accumulation of microdamage induced ...
Singh Renu - - 2013
From the last few years a debate has been continuing over the issue of malnutrition and hunger in the developing countries. The present article investigates the importance of participatory varietal selection in the development of a suitable cultivar of mungbean along with the nutritional content and the agronomic traits of ...
Passalacqua Giovanni - - 2013
Sublingual immunotherapy (SLIT) for allergic respiratory diseases was first described in 1986 and immediately appeared as a viable alternative to the traditional subcutaneous route. Since then, more than 60 randomized controlled trials have been published, almost all with very favorable results. The average improvement over placebo in symptom score and ...
Riggs Connie J - - 2013
This column discusses the need to understand generational differences, characteristics, and work habits to improve relational communication and teamwork.
Macdonald H M - - 2013
Objectives: To determine if bone health is compromised in perinatally HIV-infected youth. Methods: We assessed BMC at the proximal femur, lumbar spine and total body using DXA in perinatally HIV-infected youth (n=31; 9-18y). Using pQCT, we assessed muscle CSA, total and cortical bone area, cortical BMD and thickness and strength ...
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