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Liachko Nicole F NF Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA; Department of Medicine, University of Washington, Seattle, - - 2013
Kinase hyperactivity occurs in both neurodegenerative disease and cancer. Lesions containing hyperphosphorylated aggregated TDP-43 characterize amyotrophic lateral sclerosis and frontotemporal lobar degeneration with TDP-43 inclusions. Dual phosphorylation of TDP-43 at serines 409/410 (S409/410) drives neurotoxicity in disease models; therefore, TDP-43-specific kinases are candidate targets for intervention. To find therapeutic targets ...
Chen Yen-Kung YK Department of Nuclear Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, - - 2013
The possibility of an association of Graves' disease (GD) with subsequent cancers has been previously reported. Our study used the Taiwanese National Health Insurance Research Database (NHIRD), which identified 5025 newly diagnosed GD patients from 1997 to 2010, and 20,100 frequency matched non-GD patients. The risk of developing cancer for ...
Van Schalkwyk Marije - - 2013
In April 2010, revised Prevention of Mother-to-Child Transmission guidelines were implemented in South Africa, advising fast-tracked lifelong highly active antiretroviral therapy (HAART) initiation at a higher CD4 count (≤350 cells per microliter). This study describes the impact of these changes on the management of pregnant women who initiated HAART at ...
Lindert Steffen S Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA. - - 2013
The relaxed complex scheme is an in silico drug screening method that accounts for receptor flexibility using molecular dynamics simulations. Here, we used this approach combined with similarity searches and experimental inhibition assays to identify several low micromolar, non-bisphosphonate inhibitors, bisamidines, of farnesyl diphosphate synthase (FPPS), an enzyme targeted by ...
Lin Fang F Institute of Liver Studies, School of Medicine at King's College Hospital, King's College London, London, United - - 2013
Patients with alcohol-related liver disease (ALD) have antibodies directed to alcohol dehydrogenase (ADH), anti-ADH titers being associated with disease severity and active alcohol consumption. ADH-specific T-cell responses have not been characterized. We aimed to define anti-ADH cellular immune responses and their association with active alcohol consumption and disease severity. Using ...
Komor Alexis C AC Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, - - 2013
The discovery of cisplatin as a therapeutic agent stimulated a new era in the application of transition metal complexes for therapeutic design. Here we describe recent results on a variety of transition metal complexes targeted to DNA to illustrate many of the issues involved in new therapeutic design. We describe ...
Remmelink M - - 2013
Coronary microvascular resistance is increased after primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI), which may be related in part to changed left ventricular (LV) dynamics. Therefore we studied the coronary microcirculation in relation to systolic and diastolic LV function after STEMI. The study cohort consisted of 12 ...
Morisson Courtney C Department of Medical Physics, University of Wisconsin, Madison, WI 53705, - - 2013
The current standard for imaging castration-resistant prostate cancer (CRPC) focuses solely on detection. However, in order to assess treatment response, imaging must provide quantitative results that can be validated. Bone scintigraphy remains the most commonly used imaging tool for CRPC in bone, but with limited quantification capabilities. Both PET and ...
Salabei Joshua K JK Diabetes and Obesity Center and Institute of Molecular Cardiology, University of Louisville School of Medicine, Louisville, KY 40202, - - 2013
Vascular injury and chronic arterial diseases result in exposure of VSMCs (vascular smooth muscle cells) to increased concentrations of growth factors. The mechanisms by which growth factors trigger VSMC phenotype transitions remain unclear. Because cellular reprogramming initiated by growth factors requires not only the induction of genes involved in cell ...
Mommer Stefan S Institute of Technical and Macromolecular Chemistry, RWTH Aachen University and DWI an der RWTH Aachen e.V., Forckenbeckstr. 50, 52056 Aachen, - - 2013
A multifunctional coupler with an ethylene carbonate- and a thiolactone ring was synthesized. As proof of principle the coupler was reacted with four low-molecular weight building blocks to form a multifunctional molecule. The reactivity/selectivity of the coupler towards amines, acrylates and acyl halides was evaluated.
Beaudet Line - - 2013
ABSTRACT: The purpose of this study was to identify the principal intervention needs of elderly couples living with moderate-stage Parkinson disease and their preferences regarding the modalities of a possible nursing intervention. The study's framework of reference consisted of the transitions theory developed by Meleis, Sawyer, Im, Hilfinger Messias, and ...
Pellicori P - - 2013
Revascularisation strategies involving coronary artery bypass grafting or percutaneous interventions are the main treatments for stable coronary artery disease, particularly for patients with ongoing symptoms despite medical therapy and/or extensive ischaemia as demonstrated by either non-invasive or invasive means. Irrespective of whether revascularisation is being undertaken, all patients with stable ...
Cook Rebecca S - - 2013
BACKGROUND:: Nurses are key providers in the care of children with mild traumatic brain injury (mTBI). New treatment recommendations emphasize symptom assessment and brain rest guidelines to optimize recovery. This study compared pediatric trauma core nurses' knowledge, degree of confidence, and perceived change in practice following mTBI education. METHODS:: Twenty-eight ...
Ference Brian A - - 2013
Coronary atherosclerosis is a chronic progressive disease that begins early in life and progresses slowly over several decades before becoming clinically manifest. The causal relationship between low-density lipoprotein cholesterol (LDL-C) and the risk of coronary atherosclerosis is well established. Multiple randomized trials have demonstrated that lowering LDL-C levels during treatment ...
Provini Federica - - 2013
Agrypnia (from the Greek: to chase sleep) excitata (AE) is a syndrome characterized by loss of sleep and permanent motor and autonomic hyperactivation (excitata). Disruption of the sleep-wake rhythm consists in the disappearance of spindle-delta activities, and the persistence of stage 1 non-rapid eye movement (NREM) sleep. Rapid eye movement ...
Houseman Gail - - 2013
ABSTRACT: Research in the previous decade has found a link between amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). It is estimated that as many as 50% of all people with ALS will have some degree of cognitive impairment and that approximately 10%-25% of patients will meet the Neary criteria ...
Findeisen Hannes M - - 2013
Epigenetics involve heritable and acquired changes in gene transcription that occur independently of the DNA sequence. Epigenetic mechanisms constitute a hierarchic upper-level of transcriptional control through complex modifications of chromosomal components and nuclear structures. These modifications include, for example, DNA methylation or post-translational modifications of core histones; they are mediated ...
El Messaoudi Saloua - - 2013
In patients with diabetes mellitus, the incidence of cardiovascular disease is increased, and the outcome following cardiovascular events is worse. The antihyperglycemic drug metformin appears to limit cardiovascular death in patients with type 2 diabetes. Indeed, preclinical studies have demonstrated that metformin limits (myocardial) ischemia and reperfusion injury, independent from ...
Yuan Wen - - 2013
ABSTRACT: Patients who undergo transsphenoidal pituitary tumor resection require a multidisciplinary team approach, consisting of a neurosurgeon, an endocrinologist, and nurses. Successful transsphenoidal surgery needs expert nursing care for early identification and prompt treatment of pituitary dysfunction and neurosurgical complications. Pituitary dysfunction includes adrenal insufficiency, diabetes insipidus, syndrome of inappropriate ...
Quinones Adriana - - 2013
Cholesterol emboli syndrome is a relatively rare, but potentially devastating, manifestation of atherosclerotic disease. Cholesterol emboli syndrome is characterized by waves of arterio-arterial embolization of cholesterol crystals and atheroma debris from atherosclerotic plaques in the aorta or its large branches to small or medium caliber arteries (100-200 μm in diameter) that ...
Krakoff Lawrence R - - 2013
Accurate measurement of arterial pressure is necessary for diagnosis of hypertension and for assessment of its therapy. The development and growing application of ambulatory blood pressure monitoring (ABPM) furthers these goals. Use of ABPM has defined white coat hypertension (WCH) and masked hypertension (MH), important prognostic diagnoses. ABPM categorizes blood ...
Summ Oliver - - 2013
Indomethacin, as a member of the non-steroidal anti-inflammatory drug class, plays a special role in the treatment of headaches. By definition, it is completely efficacious in the treatment of the primary headache disorders paroxysmal hemicrania and hemicrania continua. Therefore, indomethacin is also used as a tool for differential diagnosis in ...
Chen Yu Tai - - 2013
Myasthenia gravis (MG) is an auto-immune, neuromuscular disorder, which presents with symptoms of fluctuating muscle fatigue because of a dysfunction of the neuromuscular junction. This study explores the illness experience of patients with MG, their experiences of illness, its challenges, and their coping and support strategies. In-depth interviews were undertaken ...
Vance David E DE University of Alabama at Birmingham, Birmingham, AL, USA. - - 2013
To successfully negotiate and interact with one's environment, optimal cognitive functioning is needed. Unfortunately, many neurological and psychiatric diseases impede certain cognitive abilities such as executive functioning or speed of processing; this can produce a poor fit between the patient and the cognitive demands of his or her environment. Such ...
Ortiz Ana Patricia AP Cancer Control and Population Sciences Program, University of Puerto Rico Comprehensive Cancer Center and Biostatistics and Epidemiology Department, Graduate School of Public Health, University of Puerto Rico, PMB 711, Ave de Diego89, Suite 105, San Juan, PR 00927-6346. - - 2013
This study aimed to describe the prevalence and concordance between cervical and anal human papillomavirus (HPV) infection and compare cervicovaginal and anal self-collection methods for HPV testing between physician and self-collected specimens in women in Puerto Rico. Specimens for HPV-DNA testing were obtained from 100 women aged 18 to 34 ...
Zhang H H Arkansas Biosciences Institute, Department of Biological Science, Arkansas State University, Jonesboro, AR 72467, - - 2013
Interleukin-17 (IL-17) plays an important role in several autoimmune diseases. IL-17 can induce the expression of vascular cell adhesion molecule (VCAM-1) in aortic vascular smooth muscle cells (SMCs), which is important for the development of atherosclerosis. However, the signalling pathway of IL-17-induced VCAM-1 expression remains unclear. In this study, we ...
Valdiviezo Carolina C Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, Maryland, - - 2013
This review presents the available evidence for effects of menopausal hormone replacement therapy (MHT), more specifically estrogen, and selective estrogen receptor modulators on the cardiovascular system with a focus on randomized controlled trials (RCTs) published since 2010. In contrast to early observational studies, the Women's Health Initiative, the largest randomized ...
Monroe Anne K AK Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Maryland, - - 2013
To review recent data concerning the relationship between endogenous testosterone and lipids as well as testosterone replacement therapy and lipids. To describe the effects of sex hormones on cardiovascular disease (CVD) that may act via serum lipids. Low endogenous testosterone is associated with high low-density lipoprotein and low high-density lipoprotein ...
Mirshafiee Vahid V Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, - - 2013
When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands.
Lübben Wolger - - 2013
Immunoglobulin E (IgE) production is tightly regulated at the cellular and genetic levels and is believed to be central to allergy development. At least two cellular pathways exist that lead to systemic anaphylaxis reactions in vivo: IgE-sensitized mast cells and IgG1-sensitized basophils. Passive anaphylaxis, by application of allergen and allergen-specific ...
Ito Shosuke S Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Japan. - - 2013
Although photodegradation of the retinal pigment epithelium (RPE) melanin may contribute to the etiology of age-related macular degeneration, the molecular mechanisms of this phenomenon and the structural changes of the modified melanin remain unknown. Recently, we found that the ratio of pyrrole-2,3,4,5-tetracarboxylic acid (PTeCA) to pyrrole-2,3,5-tricarboxylic acid (PTCA) is a ...
Tian Jie - - 2013
Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play a major role in tumor-induced immunosuppression, which hampers effective immuno-therapeutic approaches. β-Glucans have been reported to function as potent immuno-modulators to stimulate innate and adaptive immune responses, which contributes to their antitumor property. Here, we investigated the effect of particulate ...
Vroegindeweij Eric - - 2013
Leucine-rich repeat-containing G protein-coupled receptor (Lgr)5 is a marker for epithelial stem cells in the adult intestine of mice. Lgr5 transcripts have also been detected in the developing murine thymus, leading to speculation that Lgr5 is a marker for the long-sought stem cell of the thymus. To address the nature ...
Aracri Patrizia P Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano 20126, - - 2013
We studied how nicotinic acetylcholine receptors (nAChRs) regulate glutamate release in the secondary motor area (Fr2) of the dorsomedial murine prefrontal cortex, in the presence of steady agonist levels. Fr2 mediates response to behavioral situations that require immediate attention and is a candidate for generating seizures in the frontal epilepsies ...
Chen Chiao-Chen CC Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United - - 2013
Elucidation of epithelial transport across transcellular or paracellular pathways promises to advance the present understanding of ion transport and enables regulation of cell junctions critical to the cell and molecular biology of the epithelium. Here, we demonstrate a new instrumental technique, potentiometric scanning ion conductance microscopy (P-SICM), that utilizes a ...
Tocchi Autumn - - 2013
Similar to most proteinases, matrix metalloproteinases (MMP) do not recognize a consensus cleavage site. Thus, it is not surprising that, in a defined in vitro reaction, most MMPs can act on a wide range of proteins, including many extracellular matrix proteins. However, the findings obtained from in vivo studies with genetic models ...
Kim Sung Joon SJ Department of Chemistry and Biochemistry, Baylor University, Waco, Texas 76798, United - - 2013
Plusbacin-A3 (pb-A3) is a cyclic lipodepsipeptide that exhibits antibacterial activity against multidrug-resistant Gram-positive pathogens. Plusbacin-A3 is thought not to enter the cell cytoplasm, and its lipophilic isotridecanyl side chain is presumed to insert into the membrane bilayer, thereby facilitating either lipid II binding or some form of membrane disruption. Analogues ...
Ong Ta-Chung TC Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, - - 2013
Dynamic nuclear polarization (DNP) of amorphous and crystalline ortho-terphenyl (OTP) in the absence of glass forming agents is presented in order to gauge the feasibility of applying DNP to pharmaceutical solid-state nuclear magnetic resonance experiments and to study the effect of intermolecular structure, or lack thereof, on the DNP enhancement. ...
Alharthi Sarah A SA Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas 78249, United - - 2013
This work describes a simple, versatile, and inexpensive procedure to prepare optically transparent carbon electrodes, using proteins as precursors. Upon adsorption, the protein-coated substrates were pyrolyzed under reductive conditions (5% H2) to form ultrathin, conductive electrodes. Because proteins spontaneously adsorb to interfaces forming uniform layers, the proposed method does not ...
Pinhas Leora - - 2013
Healthy eating and weight initiatives have been incorporated into many schools to combat the growing obesity problem. There is little research, however, on the effectiveness of these programs or any inadvertent harmful effects on children's mental health. Our aims were to report on how school-based healthy weights initiatives can trigger ...
Sudzius Gintaras - - 2013
Aim: To investigate the T-helper (Th1, Th2 and Th17) cell activity in the peripheral blood of patients with primary Sjögren's syndrome (pSS), non-Sjögren's sicca syndrome (nSS) and healthy controls. Peripheral blood mononuclear cells from 34 pSS, 13 nSS patients and 13 healthy controls were stimulated, labeled for cluster of differentiation-4 ...
Chaouche-Mazouni Siham - - 2013
Malignant pleural mesothelioma (MPM) is an aggressive neoplasm with few treatment options. Reliable tumour cell lines for mesothelioma research are rare. Claudins seem to be attractive targets for cancer therapy. Aim: To establish a claudin-based MPM phenotype and to verify whether it is preserved in vitro and in vivo. Claudin-3 ...
Immerman Igor - - 2013
Internal rotation contracture is the most common shoulder deformity in patients with brachial plexus birth injury. The purpose of this investigation is to describe the indications, technique, and results of the subscapularis slide procedure. The technique involves the release of the subscapularis muscle origin off the scapula, with preservation of ...
Iannaccone Mara - - 2013
We investigated self-injurious behaviors and body modification practices in eating disorder patients, considering different ED diagnoses and illness severities. Of the total sample, 50.9% showed at least one form of self-injury and 50.9% reported at least one tattoo, piercing, or both. Patients reporting only body modifications showed more positive feelings ...
Landeck Lilla - - 2013
Background. Loss-of-function mutations in the filaggrin gene (FLG) have been reported to be associated with specific phenotypic characteristics such as hyperlinearity and keratosis pilaris. Objectives. To study phenotypic features in patients with occupational irritant contact eczema of the hands in relation to FLG loss-of-function mutations. Materials and methods. In a ...
Pires Isabel - - 2013
In order to investigate the immune mechanisms involved in regression of canine cutaneous histicytoma (CCH), major histocompatibility complex (MHC) class-II immuno-expression and the number of T- and B-lymphocytes and macrophages were analyzed in 93 cases of CCH. MHC class-II was also studied in 16 cases of CCH by immunoelectron microscopy. ...
Heffner Kathi L - - 2013
Background/Study Context: Vascular and myocardial activation can each increase blood pressure responses to stressors, but vascular responses are uniquely associated with negative affect, pernicious coping processes, and cardiovascular risk. These hemodynamic correlates of coping in response to acute stressors have not been well characterized in older adults. Methods: Adults 65 ...
Jacobsen Kirsten Rosenmaj - - 2013
The aim of the present study was to evaluate the utility of various non-invasive parameters for the prediction of tumor development and animal welfare in a murine xenograft model in male C.B-17 SCID (C.B-Igh-1(b)/IcrTac-Prkdc(scid)) mice. The study showed that body weight, food and water consumption, and an animal welfare assessment ...
Kar Sujit Kumar - - 2013
ABSTRACT: Thromboembolic phenomenon is common in pregnancy and puerperium. Thrombosis of cerebral vasculature during postpartum period may present as postpartum psychosis where catatonia may be the presenting symptoms. It is known that catatonia responds to benzodiazepines and electroconvulsive therapy. In this case report, a young woman presented with postpartum psychosis ...
Mathew Philip - - 2013
The most common complication after distal radius fractures is union with deformity. When symptomatic, distal radial malunions may require operative intervention. Numerous approaches to the distal radius have been described. Most volar approaches involve sectioning the brachioradialis and opening the first extensor compartment to permit adequate exposure. When bone graft ...
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