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Frost Poul P Danish Ramazzini Centre, Department of Occupational Medicine, Aarhus Hospital, Aarhus University Hospital, Aarhus, - - 2013
We examined whether lifestyle factors differ between patients with ulnar neuropathy confirmed by electroneurography (ENG) and those with ulnar neuropathy-like symptoms with normal ulnar nerve ENG. Among patients examined by ENG for suspected ulnar neuropathy, we identified 546 patients with ulnar neuropathy and 633 patients with ulnar neuropathy-like symptoms. These ...
Seichepine Daniel R DR Boston University Alzheimer's Disease Center, Boston University School of Medicine, Boston University, Boston, Massachusetts, - - 2013
Repetitive mild traumatic brain injury (mTBI), such as that experienced by contact-sport athletes, has been associated with the development of chronic traumatic encephalopathy (CTE). Executive dysfunction is believed to be among the earliest symptoms of CTE, with these symptoms presenting in the fourth or fifth decade of life. The present ...
Chen Yen-Kung YK Department of Nuclear Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, - - 2013
The possibility of an association of Graves' disease (GD) with subsequent cancers has been previously reported. Our study used the Taiwanese National Health Insurance Research Database (NHIRD), which identified 5025 newly diagnosed GD patients from 1997 to 2010, and 20,100 frequency matched non-GD patients. The risk of developing cancer for ...
Liachko Nicole F NF Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA; Department of Medicine, University of Washington, Seattle, - - 2013
Kinase hyperactivity occurs in both neurodegenerative disease and cancer. Lesions containing hyperphosphorylated aggregated TDP-43 characterize amyotrophic lateral sclerosis and frontotemporal lobar degeneration with TDP-43 inclusions. Dual phosphorylation of TDP-43 at serines 409/410 (S409/410) drives neurotoxicity in disease models; therefore, TDP-43-specific kinases are candidate targets for intervention. To find therapeutic targets ...
Wang Hao H Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, - - 2013
Here we present results that investigate the origins of signals observed in tip-enhanced Raman (TERS) measurements of functionalized nanoparticles. Surface enhanced Raman scattering (SERS) is known to give the largest enhancements in gap junctions. Similarly, gap-mode TERS also produces significant enhancements. The methodology developed here provides gap-mode like enhancements in ...
Durazzo Timothy C TC Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, California 94121, USA. - - 2013
The majority of the approximately 1.7 million civilians in the United States who seek emergency care for traumatic brain injury (TBI) are classified as mild (MTBI). Premorbid and comorbid conditions that commonly accompany MTBI may influence neurocognitive and functional recovery. This study assessed the influence of chronic smoking and hazardous ...
Van Schalkwyk Marije - - 2013
In April 2010, revised Prevention of Mother-to-Child Transmission guidelines were implemented in South Africa, advising fast-tracked lifelong highly active antiretroviral therapy (HAART) initiation at a higher CD4 count (≤350 cells per microliter). This study describes the impact of these changes on the management of pregnant women who initiated HAART at ...
Lindert Steffen S Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA. - - 2013
The relaxed complex scheme is an in silico drug screening method that accounts for receptor flexibility using molecular dynamics simulations. Here, we used this approach combined with similarity searches and experimental inhibition assays to identify several low micromolar, non-bisphosphonate inhibitors, bisamidines, of farnesyl diphosphate synthase (FPPS), an enzyme targeted by ...
Bethel Monique M Department of Orthopaedic Surgery, Indiana University School of Medicine, 1120 South Drive, FH 115, Indianapolis, IN 46202, USA. - - 2013
Osteoblasts (OBs) and adipocytes (APs) share a common mesenchymal ancestor. It is now clear that mesenchymal stem cell (MSC) maturation along the OB lineage comes at the expense of adipogenesis and vice versa. During aging, this balance increasingly favors the formation of APs. Hematopoiesis also slowly declines during the aging ...
Lin Fang F Institute of Liver Studies, School of Medicine at King's College Hospital, King's College London, London, United - - 2013
Patients with alcohol-related liver disease (ALD) have antibodies directed to alcohol dehydrogenase (ADH), anti-ADH titers being associated with disease severity and active alcohol consumption. ADH-specific T-cell responses have not been characterized. We aimed to define anti-ADH cellular immune responses and their association with active alcohol consumption and disease severity. Using ...
Schonhoff Christopher M CM Departments of Biomedical Sciences, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, - - 2013
Taurolithocholate (TLC) acutely inhibits the biliary excretion of multidrug-resistant associated protein 2 (Mrp2) substrates by inducing Mrp2 retrieval from the canalicular membrane, whereas cyclic adenosine monophosphate (cAMP) increases plasma membrane (PM)-MRP2. The effect of TLC may be mediated via protein kinase Cϵ (PKCϵ). Myristoylated alanine-rich C kinase substrate (MARCKS) is ...
Komor Alexis C AC Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, - - 2013
The discovery of cisplatin as a therapeutic agent stimulated a new era in the application of transition metal complexes for therapeutic design. Here we describe recent results on a variety of transition metal complexes targeted to DNA to illustrate many of the issues involved in new therapeutic design. We describe ...
Remmelink M - - 2013
Coronary microvascular resistance is increased after primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI), which may be related in part to changed left ventricular (LV) dynamics. Therefore we studied the coronary microcirculation in relation to systolic and diastolic LV function after STEMI. The study cohort consisted of 12 ...
Morisson Courtney C Department of Medical Physics, University of Wisconsin, Madison, WI 53705, - - 2013
The current standard for imaging castration-resistant prostate cancer (CRPC) focuses solely on detection. However, in order to assess treatment response, imaging must provide quantitative results that can be validated. Bone scintigraphy remains the most commonly used imaging tool for CRPC in bone, but with limited quantification capabilities. Both PET and ...
Salabei Joshua K JK Diabetes and Obesity Center and Institute of Molecular Cardiology, University of Louisville School of Medicine, Louisville, KY 40202, - - 2013
Vascular injury and chronic arterial diseases result in exposure of VSMCs (vascular smooth muscle cells) to increased concentrations of growth factors. The mechanisms by which growth factors trigger VSMC phenotype transitions remain unclear. Because cellular reprogramming initiated by growth factors requires not only the induction of genes involved in cell ...
Kazer Meredith W MW Fairfield University School of Nursing, Fairfield, CT 06824, USA. - - 2013
To summarize the literature on psychosocial responses to active surveillance as well as educational and support strategies to promote adherence. There are two prevalent responses among men undergoing active surveillance; anxiety and uncertainty. The education of a patient about low-risk prostate cancer as well as the inquiry by the physician ...
Mommer Stefan S Institute of Technical and Macromolecular Chemistry, RWTH Aachen University and DWI an der RWTH Aachen e.V., Forckenbeckstr. 50, 52056 Aachen, - - 2013
A multifunctional coupler with an ethylene carbonate- and a thiolactone ring was synthesized. As proof of principle the coupler was reacted with four low-molecular weight building blocks to form a multifunctional molecule. The reactivity/selectivity of the coupler towards amines, acrylates and acyl halides was evaluated.
Beaudet Line - - 2013
ABSTRACT: The purpose of this study was to identify the principal intervention needs of elderly couples living with moderate-stage Parkinson disease and their preferences regarding the modalities of a possible nursing intervention. The study's framework of reference consisted of the transitions theory developed by Meleis, Sawyer, Im, Hilfinger Messias, and ...
Pellicori P - - 2013
Revascularisation strategies involving coronary artery bypass grafting or percutaneous interventions are the main treatments for stable coronary artery disease, particularly for patients with ongoing symptoms despite medical therapy and/or extensive ischaemia as demonstrated by either non-invasive or invasive means. Irrespective of whether revascularisation is being undertaken, all patients with stable ...
Cook Rebecca S - - 2013
BACKGROUND:: Nurses are key providers in the care of children with mild traumatic brain injury (mTBI). New treatment recommendations emphasize symptom assessment and brain rest guidelines to optimize recovery. This study compared pediatric trauma core nurses' knowledge, degree of confidence, and perceived change in practice following mTBI education. METHODS:: Twenty-eight ...
Ference Brian A - - 2013
Coronary atherosclerosis is a chronic progressive disease that begins early in life and progresses slowly over several decades before becoming clinically manifest. The causal relationship between low-density lipoprotein cholesterol (LDL-C) and the risk of coronary atherosclerosis is well established. Multiple randomized trials have demonstrated that lowering LDL-C levels during treatment ...
Provini Federica - - 2013
Agrypnia (from the Greek: to chase sleep) excitata (AE) is a syndrome characterized by loss of sleep and permanent motor and autonomic hyperactivation (excitata). Disruption of the sleep-wake rhythm consists in the disappearance of spindle-delta activities, and the persistence of stage 1 non-rapid eye movement (NREM) sleep. Rapid eye movement ...
Houseman Gail - - 2013
ABSTRACT: Research in the previous decade has found a link between amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). It is estimated that as many as 50% of all people with ALS will have some degree of cognitive impairment and that approximately 10%-25% of patients will meet the Neary criteria ...
Findeisen Hannes M - - 2013
Epigenetics involve heritable and acquired changes in gene transcription that occur independently of the DNA sequence. Epigenetic mechanisms constitute a hierarchic upper-level of transcriptional control through complex modifications of chromosomal components and nuclear structures. These modifications include, for example, DNA methylation or post-translational modifications of core histones; they are mediated ...
El Messaoudi Saloua - - 2013
In patients with diabetes mellitus, the incidence of cardiovascular disease is increased, and the outcome following cardiovascular events is worse. The antihyperglycemic drug metformin appears to limit cardiovascular death in patients with type 2 diabetes. Indeed, preclinical studies have demonstrated that metformin limits (myocardial) ischemia and reperfusion injury, independent from ...
Yuan Wen - - 2013
ABSTRACT: Patients who undergo transsphenoidal pituitary tumor resection require a multidisciplinary team approach, consisting of a neurosurgeon, an endocrinologist, and nurses. Successful transsphenoidal surgery needs expert nursing care for early identification and prompt treatment of pituitary dysfunction and neurosurgical complications. Pituitary dysfunction includes adrenal insufficiency, diabetes insipidus, syndrome of inappropriate ...
Quinones Adriana - - 2013
Cholesterol emboli syndrome is a relatively rare, but potentially devastating, manifestation of atherosclerotic disease. Cholesterol emboli syndrome is characterized by waves of arterio-arterial embolization of cholesterol crystals and atheroma debris from atherosclerotic plaques in the aorta or its large branches to small or medium caliber arteries (100-200 μm in diameter) that ...
Krakoff Lawrence R - - 2013
Accurate measurement of arterial pressure is necessary for diagnosis of hypertension and for assessment of its therapy. The development and growing application of ambulatory blood pressure monitoring (ABPM) furthers these goals. Use of ABPM has defined white coat hypertension (WCH) and masked hypertension (MH), important prognostic diagnoses. ABPM categorizes blood ...
Summ Oliver - - 2013
Indomethacin, as a member of the non-steroidal anti-inflammatory drug class, plays a special role in the treatment of headaches. By definition, it is completely efficacious in the treatment of the primary headache disorders paroxysmal hemicrania and hemicrania continua. Therefore, indomethacin is also used as a tool for differential diagnosis in ...
Chen Yu Tai - - 2013
Myasthenia gravis (MG) is an auto-immune, neuromuscular disorder, which presents with symptoms of fluctuating muscle fatigue because of a dysfunction of the neuromuscular junction. This study explores the illness experience of patients with MG, their experiences of illness, its challenges, and their coping and support strategies. In-depth interviews were undertaken ...
Vance David E DE University of Alabama at Birmingham, Birmingham, AL, USA. - - 2013
To successfully negotiate and interact with one's environment, optimal cognitive functioning is needed. Unfortunately, many neurological and psychiatric diseases impede certain cognitive abilities such as executive functioning or speed of processing; this can produce a poor fit between the patient and the cognitive demands of his or her environment. Such ...
Ortiz Ana Patricia AP Cancer Control and Population Sciences Program, University of Puerto Rico Comprehensive Cancer Center and Biostatistics and Epidemiology Department, Graduate School of Public Health, University of Puerto Rico, PMB 711, Ave de Diego89, Suite 105, San Juan, PR 00927-6346. - - 2013
This study aimed to describe the prevalence and concordance between cervical and anal human papillomavirus (HPV) infection and compare cervicovaginal and anal self-collection methods for HPV testing between physician and self-collected specimens in women in Puerto Rico. Specimens for HPV-DNA testing were obtained from 100 women aged 18 to 34 ...
Zhang H H Arkansas Biosciences Institute, Department of Biological Science, Arkansas State University, Jonesboro, AR 72467, - - 2013
Interleukin-17 (IL-17) plays an important role in several autoimmune diseases. IL-17 can induce the expression of vascular cell adhesion molecule (VCAM-1) in aortic vascular smooth muscle cells (SMCs), which is important for the development of atherosclerosis. However, the signalling pathway of IL-17-induced VCAM-1 expression remains unclear. In this study, we ...
Valdiviezo Carolina C Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, Maryland, - - 2013
This review presents the available evidence for effects of menopausal hormone replacement therapy (MHT), more specifically estrogen, and selective estrogen receptor modulators on the cardiovascular system with a focus on randomized controlled trials (RCTs) published since 2010. In contrast to early observational studies, the Women's Health Initiative, the largest randomized ...
Monroe Anne K AK Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Maryland, - - 2013
To review recent data concerning the relationship between endogenous testosterone and lipids as well as testosterone replacement therapy and lipids. To describe the effects of sex hormones on cardiovascular disease (CVD) that may act via serum lipids. Low endogenous testosterone is associated with high low-density lipoprotein and low high-density lipoprotein ...
Mirshafiee Vahid V Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, - - 2013
When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands.
Xia Yan Y Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, - - 2013
Site-specific protein conjugates with RAFT polymers were synthesized using expressed protein ligation. Stable micelles were formed from both linear block copolymer and Y-shaped conjugates.
Knorr David A DA Department of Medicine (Hematology, Oncology, and Transplant), University of Minnesota, Minneapolis, Minnesota 55455, - - 2013
Human embryonic stem cell (hESC)-derived natural killer (NK) cells are a promising source of antitumor lymphocytes for immunotherapeutics. They also provide a genetically tractable platform well suited for the study of antitumor immunotherapies in preclinical models. We have previously demonstrated the potency of hESC-derived NK cells in vivo. Here we ...
Declercq Jeroen J Stem Cell Institute , KULeuven, Leuven, - - 2013
Zinc finger protein of the cerebellum (Zic)3, a member of Gli family of transcription factors (TFs), is essential for maintaining pluripotency of embryonic stem cells (ESCs) and has been reported to activate TF Nanog in an Oct4/Sox2-independent manner. Previously, we showed that Zic3 (Z), in combination with the Yamanka factors ...
Lübben Wolger - - 2013
Immunoglobulin E (IgE) production is tightly regulated at the cellular and genetic levels and is believed to be central to allergy development. At least two cellular pathways exist that lead to systemic anaphylaxis reactions in vivo: IgE-sensitized mast cells and IgG1-sensitized basophils. Passive anaphylaxis, by application of allergen and allergen-specific ...
Ito Shosuke S Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Japan. - - 2013
Although photodegradation of the retinal pigment epithelium (RPE) melanin may contribute to the etiology of age-related macular degeneration, the molecular mechanisms of this phenomenon and the structural changes of the modified melanin remain unknown. Recently, we found that the ratio of pyrrole-2,3,4,5-tetracarboxylic acid (PTeCA) to pyrrole-2,3,5-tricarboxylic acid (PTCA) is a ...
Sandiego Christine M CM Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06520, USA. - - 2013
Detecting changes in receptor binding at the metabotropic glutamate receptor 5 (mGluR5) with the PET allosteric antagonist, [¹¹C]ABP688, may be valuable for studying dysfunctional glutamate transmission associated with psychiatric illnesses. This study was designed to validate the findings of a recent pilot study in baboons which reported a significant global ...
Dearden Albert K AK Department of Physics, Applied Physics, and Astronomy, Rensselaer Polytechnic Institute, Troy, New York 12180, - - 2013
Protein splicing is an autocatalytic process where an "intein" self-cleaves from a precursor and ligates the flanking N- and C-"extein" polypeptides. Inteins occur in all domains of life and have myriad uses in biotechnology. Although the reaction steps of protein splicing are known, mechanistic details remain incomplete, particularly the initial ...
Tian Jie - - 2013
Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play a major role in tumor-induced immunosuppression, which hampers effective immuno-therapeutic approaches. β-Glucans have been reported to function as potent immuno-modulators to stimulate innate and adaptive immune responses, which contributes to their antitumor property. Here, we investigated the effect of particulate ...
Vroegindeweij Eric - - 2013
Leucine-rich repeat-containing G protein-coupled receptor (Lgr)5 is a marker for epithelial stem cells in the adult intestine of mice. Lgr5 transcripts have also been detected in the developing murine thymus, leading to speculation that Lgr5 is a marker for the long-sought stem cell of the thymus. To address the nature ...
Steinbrenner Holger H Institute for Biochemistry and Molecular Biology I, Heinrich-Heine-University, Düsseldorf, - - 2013
Adequate and supranutritional selenium (Se) intake, maintaining full expression of selenoproteins, has been assumed to be beneficial for human health with respect to prevention of cancer. Strikingly, the effectiveness of dietary Se supplementation depends on many factors: baseline Se status, age, gender, and genetic background of an individual; type of ...
Aracri Patrizia P Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano 20126, - - 2013
We studied how nicotinic acetylcholine receptors (nAChRs) regulate glutamate release in the secondary motor area (Fr2) of the dorsomedial murine prefrontal cortex, in the presence of steady agonist levels. Fr2 mediates response to behavioral situations that require immediate attention and is a candidate for generating seizures in the frontal epilepsies ...
Chen Chiao-Chen CC Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United - - 2013
Elucidation of epithelial transport across transcellular or paracellular pathways promises to advance the present understanding of ion transport and enables regulation of cell junctions critical to the cell and molecular biology of the epithelium. Here, we demonstrate a new instrumental technique, potentiometric scanning ion conductance microscopy (P-SICM), that utilizes a ...
Canagarajah Bertram J BJ Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, - - 2013
The clathrin-associated adaptor protein (AP) complexes AP-1 and AP-2 are two members of a family of heterotetrameric assemblies that connect transmembrane protein cargo to vesicular coats. Cargo binding by AP-1 is activated by the small GTPase Arf1, while AP-2 is activated by the phosphoinositide PI(4,5)P₂. The structures of both AP-1 ...
Tocchi Autumn - - 2013
Similar to most proteinases, matrix metalloproteinases (MMP) do not recognize a consensus cleavage site. Thus, it is not surprising that, in a defined in vitro reaction, most MMPs can act on a wide range of proteins, including many extracellular matrix proteins. However, the findings obtained from in vivo studies with genetic models ...
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