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Results 301 - 350 of 3060
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Brusa Davide - - 2013
OBJECTIVES: A dendritic cell-based cancer vaccine has recently received Food and Drug Administration approval in the USA based on its ability to prolong the survival of prostate cancer patients with advanced disease. However, tumor-mediated immunosuppressive mechanisms might represent an obstacle to optimal performance of this therapy. We have recently shown ...
Bhambure R - - 2013
This paper describes the development of a HTPD platform for process development of chromatography steps. An assessment of the platform as a guidance tool for establishing the "characterization space" for an ion exchange chromatography step has been performed by using design of experiments (DOE). Case studies involving use of a ...
Jana Manas - - 2013
A significantly fast reaction condition for the exclusive preparation β-glycosyl thiol derivatives has been developed successfully. The reaction condition is one-step, fast, high yielding, highly stereoselective, and requires only benchtop chemicals. Further reaction of glycosyl thiol derivatives with Michael acceptors and alkylating agents furnished thioglycosides and (1,1)-thiolinked trehalose analogs.
Das Sumana - - 2013
Phenol is a common substance present in many industrial wastewaters and in nonspecific pesticides. Due to its solubility and volatility phenol is often found in marine and freshwater environment. It is lipophilic compound and has a high potential for accumulating along the trophic chain. Phenol thus is not only a ...
Pelletier Caroline C CC Université de Lyon, Lyon, - - 2013
Chronic kidney disease (CKD) is frequently associated with protein-energy wasting, a recognized strong predictive factor of mortality. Zinc α2-glycoprotein (ZAG) is a new adipokine involved in body weight control through its lipid-mobilizing activity. Here we tested whether the uremic environment in CKD could alter ZAG production by white adipose tissue ...
Saha Subhrakanti - - 2013
This work describes the development and application of a new thermal desorption technique that makes use of the Leidenfrost phenomenon in open ion sources at atmospheric pressure for direct mass spectrometric detection of ultratrace levels of illicit, therapeutic, and stimulant drugs, toxicants, and peptides (molecular weight above 1 kDa) in their ...
Crnovčić Ivana - - 2013
Streptomyces chrysomallus and Streptomyces parvulus produce novel C-demethylactinomycins besides their normal actinomycins when fed with 3-hydroxyanthranilic acid (3-HA). The 3-HA is incorporated into pentapeptide lactone precursors in competition with the regular precursor 4-methyl-3-hydroxyanthranilic acid (4-MHA). The resultant 3-HA pentapeptide lactones can condense with each other, as well as with the ...
Askari G - - 2013
Background/objective:The study was carried out to assess the relationship between nut consumption and lipid profile among Iranian adults.Subject/methods:The study was based on data from the Isfahan Healthy Heart Program across three counties in central Iran in 2007. A cross-sectional survey of 9660 randomly selected adults aged 19 years were chosen ...
Tasi Yung-Chieh - - 2013
PURPOSE: Asthenozoospermia is a major cause of male infertility. However, the molecular mechanisms underlying sperm-motility defects remain largely unknown in the majority of cases. In our previous study, we applied a proteomic approach to identify unknown proteins that were downregulated in spermatozoa with low motility compared to spermatozoa with good ...
Kapoor C S - - 2013
Plants can be used as both passive biomonitors and biomitigators in urban and industrial environments to indicate the environmental quality and to ameliorate pollution level in a locality. Many studies reveal that plants are negatively affected by the ambient levels of air pollutants. The present study was conducted to evaluate ...
Slattery E - - 2013
INTRODUCTION: Spending on hospital inpatients comprises a major proportion of healthcare costs. This study assessed the impact of systematic feedback to gastroenterologists on the cost of care provided to inpatients on a gastrointestinal/hepatology (GIH) hospital service. METHODS: Patients with a GIH diagnosis were randomly assigned to be cared for by ...
Wink J - - 2013
BACKGROUND: Segmental dose reduction with increasing age after thoracic epidural anaesthesia (TEA) has been documented. We hypothesised that after a fixed loading dose of ropivacaine at the T3-T4 level, increasing age would result in more extended analgesic spread. In addition, other aspects of neural blockade and haemodynamic changes were studied. ...
Park Sooyeon - - 2013
A Gram-staining-negative, non-spore-forming, aerobic, non-flagellated, non-gliding and rod-shaped bacterial strain, designated M-M3(T), was isolated from marine sand on the southern coast of South Korea and subjected to a polyphasic study. Strain M-M3(T) was observed to grow optimally at 25-30 °C, at pH 7.0-8.0 and in the presence of 2 % (w/v) NaCl. ...
Solomonia Revaz O - - 2013
There is strong evidence that a restricted part of the chick forebrain, the intermediate medial mesopallium (IMM), stores information acquired through the learning process of visual imprinting. We have previously demonstrated that at 1 h but not 24 h after imprinting training, a learning-specific increase in the amount of membrane Thr286-autophosphorylated α-calcium/calmodulin-dependent ...
Tosh S M - - 2013
Oat and barley foods have been shown to reduce human glycaemic response, compared to similar wheat foods or a glucose control. The strength of the evidence supporting the hypothesis that the soluble fibre, mixed linkage β-glucan, reduces glycaemic response was evaluated. A search of the literature was conducted to find ...
Shi Dangwei - - 2013
We report a simple, rapid and efficient strategy for modification of gold nanorods (AuNRs) with thiolated DNA at low solution pH and high salt concentration. DNA functionalized AuNRs were then used to assemble with DNA modified gold nanoparticles to form discrete satellite nanostructures.
Lauretti Gabriela Rocha - - 2013
Fibromyalgia is characterized by a range of symptoms that include muscle pain, fatigue and sleep disorders. Transcutaneous electrical nerve stimulation (TENS) is an established method for pain relief. The purpose of the study was to evaluate the effectiveness and safety of the use of two simultaneously new TENS devices for ...
Moya Mireya - - 2013
During spring of 2009, a new influenza virus AH1N1 spread in the world causing acute respiratory illness and death, resulting in the first influenza pandemic since 1968. Blood levels of potentially-toxic and essential elements of 40 pneumonia and confirmed AH1N1 were evaluated against two different groups of controls, both not ...
Buysse Daniel J DJ Neuroscience Clinical and Translational Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. - - 2013
Insomnia is one of the most prevalent health concerns in the population and in clinical practice. Clinicians may be reluctant to address insomnia because of its many potential causes, unfamiliarity with behavioral treatments, and concerns about pharmacologic treatments. To review the assessment, diagnosis, and treatment of insomnia in adults. Systematic ...
De Storme Nico N Department of Plant Production, Faculty of Bioscience Engineering, University of Ghent, Coupure Links 653, B-9000, Gent, - - 2013
In the plant kingdom, events of whole genome duplication or polyploidization are generally believed to occur via alterations of the sexual reproduction process. Thereby, diploid pollen and eggs are formed that contain the somatic number of chromosomes rather than the gametophytic number. By participating in fertilization, these so-called 2n gametes ...
Salmeri M - - 2013
The key aspect of neonatal meningitis is related to the ability of pathogens to invade the blood-brain barrier (BBB) and to penetrate the central nervous system. In the present study we show that, in an in vitro model of BBB, on the basis of co-culturing primary bovine brain endothelial cells ...
Hein Rebecca R Unit of Genetic Epidemiology, Division of Cancer Epidemiology (C020), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, - - 2013
Menopausal hormone therapy (MHT) is associated with an elevated risk of breast cancer in postmenopausal women. To identify genetic loci that modify breast cancer risk related to MHT use in postmenopausal women, we conducted a two-stage genome-wide association study (GWAS) with replication. In stage I, we performed a case-only GWAS ...
Furuya Takefumi - - 2013
To determine the prevalence of vitamin D deficiency and associations with clinical characteristics in Japanese patients with rheumatoid arthritis (RA), serum 25(OH)D levels, laboratory data, and clinical data were obtained from 4,793 patients with RA (4,075 women, 718 men, mean age 59.7 years) who participated in the Institute of Rheumatology Rheumatoid ...
Marcellin Fabienne - - 2013
AIMS: Studying alcohol abuse impact, as measured by physicians' perceptions and patients' self-reports, on HIV virological rebound among patients chronically co-infected with HIV and hepatitis C virus (HCV). DESIGN: Cohort study. SETTING: Seventeen French hospitals. PARTICIPANTS: 512 patients receiving antiretroviral therapy (ART) with an undetectable initial HIV viral load and ...
Banerjee Arnab - - 2013
A visible light excitable rhodamine based probe operates as a SCN(-) selective fluorescent "turn-on" sensor for living cell imaging with a detection limit of 0.01 μM, which is much lower than the normal SCN(-) level in the human body. A "lock" and "key" model has been proposed to explain the ...
Stergiou-Kita Mary - - 2013
Purpose A systematic literature review was undertaken to gather evidence to develop a guideline for vocational evaluation following burn injuries (BI). This review aimed to identify the key processes evaluators should follow and the key factors they should consider when completing such evaluations. Methods Steps outlined in Cochrane Handbook of ...
Sawa Yoshiki - - 2013
Although legislation regarding organ transplantation from brain-dead donors in Japan was approved in 1997, no heart-lung transplantation procedures were performed for some time. Herein, we report the first case of successful heart-lung transplantation in Japan. The recipient was a 35-year-old man with Eisenmenger syndrome, caused by a double outlet right ...
Christison-Lagay Emily - - 2013
BACKGROUND: Thymectomy is a well-established treatment for generalized myasthenia gravis in adults, but predictors of long-term efficacy and the optimum timing for intervention in juvenile myasthenia remain controversial. PURPOSE: To review the preoperative presentation, surgical experience, and long-term neuromuscular follow-up in patients undergoing thoracoscopic thymectomy in a single institution. METHODS: ...
Ardeljan Daniel D Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, - - 2013
Age-related macular degeneration (AMD) is a leading cause of irreversible central visual loss in the elderly. A recent genome-wide association studies (GWAS) reported that rs9621532 near the tissue inhibitor of metalloproteinase 3 (TIMP3)/synapsin III (SYN3) region of 22q12.3 is associated with AMD. In this study, we characterize its phenotypic influence ...
Estrada Beatriz - - 2013
Soil salinity restricts plant growth and productivity. Na(+) represents the major ion causing toxicity because it competes with K(+) for binding sites at the plasma membrane. Inoculation with arbuscular mycorrhizal fungi (AMF) can alleviate salt stress in the host plant through several mechanisms. These may include ion selection during the ...
Dufour Matthieu - - 2013
Cysteine-conjugated volatile thiols are powerful aromatic compounds that contribute to the fruity notes of many white wines and especially Sauvignon Blanc. Genetic selection programs of wine yeast starters able to produce more volatile thiols constitute, therefore, an important goal for the wine industry. Recent investigations on yeast metabolism suggested that ...
Kul Seval - - 2013
In this study, we conducted a meta-analysis of self-controlled cohort studies comparing body weights, blood levels of lipids and fasting blood glucose levels before and after Ramadan taking into account gender differences. Several databases were searched up to June 2012 for studies showing an effect of Ramadan fasting in healthy ...
Abdelhamid Ghada - - 2013
The objective of the current study was to investigate the effect of vanadium (V(5+)) on Cyp1 expression and activity in C57BL/6 mice liver and isolated hepatocytes. For this purpose, C57BL6 mice were injected intraperitoneally with V(5+) (5 mg/kg) in the absence and presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (15 μg/kg) for 6 and 24 h. ...
Yin Shi - - 2013
Reaction of CO with H(2) on neutral Fe(m)S(n) clusters in a fast flow reactor is investigated both experimentally and theoretically. Single photon ionization at 118 nm is used to detect neutral cluster distributions through time of flight mass spectrometry. Fe(m)S(n) clusters are generated through laser ablation of a mixed iron-sulfur ...
Methner Carmen C Department of Medicine, University of Cambridge, Addenbrooke's Hospital Box 110, Cambridge CB2 2QQ, - - 2013
Protein kinase G type I (PKGI) plays a critical role in survival signaling of pre- and postconditioning downstream of cardiac cGMP. However, it is unclear whether PKGI exerts its protective effects in the cardiomyocyte or if other cardiac cell types are involved, and whether nitric oxide (NO) metabolism can target ...
Xing-Mao Zhang - - 2013
Laparoscopic colorectal resection has been extensively accepted for treatment of colorectal cancer. There are several reports about surgeon's age as a factor to have influence on learning laparoscopic approach, and there is no consensus on this point. This study was designed to evaluate the outcomes of laparoscopic colorectal resection in ...
López-Olmeda J F - - 2013
The endocrine axis controlling the stress response displays daily rhythms in many factors such as adrenal sensitivity and cortisol secretion. These rhythms have mostly been described in mammals, whereas they are poorly understood in teleost fish, so that their impact on fish welfare in aquaculture remains unexplored. In the present ...
Ney M - - 2013
BACKGROUND: Malnutrition is a common and clinically significant problem in patients with cirrhosis. The impact of nutritional therapy remains unclear. AIM: To provide an up-to-date systematic review and meta-analysis of RCTs of oral or enteral nutritional supplementation (ONS or ENS) on nutritional and clinical outcomes in adult patients with cirrhosis. ...
Plummer Ruth - - 2013
PURPOSE: poly(ADP ribose) polymerase inhibition has been shown to potentiate the cytotoxicity of DNA damaging agents. A phase I study of rucaparib and temozolomide showed that full-dose temozolomide could be given during PARP inhibition. We report the results of a phase II study of intravenous rucaparib 12 mg/m(2) and oral temozolomide ...
Li Ning - - 2013
The complete mitochondrial genome of the Pacific sand lance Ammodytes hexapterus was determined. The entire sequence is 16,527 bp in length assembling 22 tRNAs, 2 rRNAs and 13 protein-coding genes as well as the putative control region and O(L). The gene arrangement and component are identical to those of canonical vertebrate ...
de Castro Leonardo D - - 2013
The Philippine government officially responded to the Declaration of Istanbul on Organ Trafficking and the related WHO Guidelines on organ transplantation by prohibiting all transplants to foreigners using Filipino organs. However, local tourists have escaped the regulatory radar, leaving a very wide gap in efforts against human trafficking and transplant ...
Wang Y - - 2013
Catechol-O-methyltransferase (COMT) Val158Met (rs4680) polymorphism plays a crucial role in regulating brain dopamine level. Converging evidence from Caucasian samples showed that, compared with rs4680 Val allele, the Met allele was linked to lower COMT activity, which in turn was linked to better cognitive performance such as working memory (WM) and ...
Itoh Kyoto - - 2013
Lethal congenital contracture syndrome (LCCS) is an autosomal recessive disease, characterized by the fetal akinesia phenotype, with multiple contractures of joints and degeneration of motor neurons in the spinal cord as the main neuropathological findings [1, 2, 3, 4, 5]. Recent studies have shown that the defective gene underlying the ...
Miao Rong - - 2013
A novel, facile and effective method for modification of SiNWs or SiNW arrays has been developed. In this method, reaction between reductive Si-H bonds on the surface of SiNWs and the aldehyde group containing in organic molecules has been used for immobilization of organic molecules onto the surface of SiNW ...
Song Z - - 2013
OBJECTIVE: This retrospective analysis evaluates the clinical outcomes of extensive-stage small cell lung cancer (SCLC) patients who received second-line chemotherapy after platinum-based first-line chemotherapy, especially focusing on efficacy and toxicity between single-agent and combination chemotherapy. METHODS: We retrospectively reviewed 193 patients who received second-line chemotherapy for extensive-stage SCLC. Patients relapsing ...
Wagner Michael - - 2013
Interactions between the enteric nervous system and the immune system are suggested to play an important role in the pathophysiology of inflammatory bowel disease (IBD). This study aims to determine if chromogranin A (CgA), chromogranin B (CgB), and secretoneurin (SN) are detectable in feces (F) from patients with collagenous colitis ...
McAdam Scott A M - - 2013
Little is known about how a predominantly passive hydraulic stomatal control in ferns and lycophytes might impact water use under stress. Ferns and lycophytes occupy a diverse array of habitats, from deserts to rainforest canopies, raising the question of whether stomatal behaviour is the same under all ecological strategies and ...
Song Zhong-Bang - - 2013
Formaldehyde (HCHO) is suggested to be detoxified through one-carbon (C1) metabolism or assimilated by the Calvin Cycle in plants. To further understand the function of the Calvin Cycle and C1 metabolism in HCHO-metabolism in plants, HCHO-elimination and -metabolism by Arabidopsis thaliana in HCHO solutions was investigated in this study. Results ...
Wang Wei - - 2013
Clinical classification and age distribution in myasthenia gravis (MG) cases seem different between Oriental and Caucasian populations, but there have rarely been any clinical studies on MG patients from mainland China. The goal of the current study was to perform a comprehensive survey of myasthenia gravis in a hospital in ...
Kim Sung Hoon - - 2013
BACKGROUND: Although mortality after liver resection has declined, posthepatectomy liver failure (PHLF) remains a major cause of operative mortality. To date there is not consensus on a definition for PHLF. However, there have been many efforts to define PHLF causing operative mortality. In the present study we sought to identify ...
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