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McKown Robert L RL Department of Integrated Science and Technology, James Madison University, Harrisonburg, VA, - - 2013
Lacritin is a prosecretory mitogen in tears and, although a tear protein, it promotes basal tearing and lacrimal gland secretion. Since scale up is relevant to its potential use in the treatment of dry eye, we explored various mutagenic strategies to alter the stability, solubility, and translational efficiency of nascent ...
Awadalla Mona S MS Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia. - - 2013
Recently, several studies have investigated genetic associations between Cytochrome P450 (CYP1B1), Endothelial nitric oxide synthase (eNOS), and Neurotrophin-4 (NTF4) with primary angle-closure glaucoma (PACG) in various ethnic groups. We investigated the association of these candidate genes with PACG in samples from Australia and Nepal. A total of 235 patients with ...
Mahoney Emilia E Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus, OH, - - 2013
Chronic lymphocytic leukemia (CLL) is a mature B cell malignancy and is the most prevalent type of leukemia in adults. There is no curative therapy for this disease; however, several new agents have shown very promising results. Autophagy has not been studied in CLL and in this study we first ...
Venkatesh Sudhakar K SK Diagnostic Radiology, National University of Singapore, - - 2013
Many pathological processes cause marked changes in the mechanical properties of tissue. MR elastography (MRE) is a noninvasive MRI based technique for quantitatively assessing the mechanical properties of tissues in vivo. MRE is performed by using a vibration source to generate low frequency mechanical waves in tissue, imaging the propagating ...
Diallo Diawo D Unité d'Entomologie Médicale, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220, Dakar, - - 2013
Dengue (DENV), yellow fever (YFV) and chikungunya (CHIKV) viruses circulate in sylvatic, enzootic transmission cycles in southeastern Senegal, but understanding of the vector-host interactions involved is limited. The vertebrate hosts of several potential mosquito vectors of the three viruses were identified by PCR amplification and sequencing portions of the cytochrome ...
Pinto Bernardine M BM Centers for Behavioral and Preventive Medicine, Miriam Hospital, Providence, RI 02903, USA. - - 2013
Maintenance of exercise after completing phase II cardiac rehabilitation (CR) is challenging for many patients. We offered a telephone-based maintenance intervention and found improvement in exercise participation in the intervention group at 12 months post-CR discharge. We examined the effects of the intervention on psychosocial outcomes. The effects of a ...
Lublin Fred D FD Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Department of Neurology, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. - - 2013
A double-blind, randomized, controlled study was undertaken to determine whether combined use of interferon β-1a (IFN) 30 μg intramuscularly weekly and glatiramer acetate (GA) 20 mg daily is more efficacious than either agent alone in relapsing-remitting multiple sclerosis. A total of 1,008 participants were randomized and followed until the last ...
Jones Jermaine D JD Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. - - 2013
Although opioid substitution therapy is an effective clinical tool used to manage opioid abuse and dependence, concerns regarding the current FDA-approved medications have lead to a search for efficacious, non-opioid medications. Preclinical data indicate that neurokinin 1 (NK1) receptor activity may modulate opioid effects and withdrawal. This investigation sought to ...
Anton-Erxleben Katharina K Psychology & Neural Science, Meyer Building, 6 Washington Place, Room 970, New York University, New York, New York 10003, USA. - - 2013
Attention allows us to select relevant sensory information for preferential processing. Behaviourally, it improves performance in various visual tasks. One prominent effect of attention is the modulation of performance in tasks that involve the visual system's spatial resolution. Physiologically, attention modulates neuronal responses and alters the profile and position of ...
Hartwell Karen J KJ Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA. - - 2013
Varenicline has been shown to reduce cigarette craving during a quit attempt. Use BOLD fMRI to explore differences in smoking cue reactivity at baseline and after five weeks of varenicline smoking cessation treatment. Treatment-seeking nicotine-dependent adult smokers underwent BOLD fMRI scans with block presentation of visual smoking, neutral, and rest ...
Meng Huan H Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, - - 2013
We compared the cellular phenotypes and studied the role of autophagy in the pathogenesis of Fuchs endothelial corneal dystrophy (FECD) using two α2 collagen VIII (Col8a2) knock-in mouse models and human FECD tissues. In vivo corneal endothelial cell (CEC) counts and morphology were analyzed by clinical confocal microscopy. Ultrastructural analysis ...
Nirogi Ramakrishna R Department of ADME, Discovery Research, Suven Life Sciences Ltd ., Hyderabad - 500055, India. - - 2013
Epidemiologic studies and clinical assessment of schizophrenic population have revealed a high incidence of overlap between schizophrenia and addictive disorders. The aim of the present investigation was to study the effect of aripiprazole in a preclinical animal model of chronic alcohol self-administration (CASA) and also to evaluate the influence of ...
Perry Anamarija M AM Department of Pathology, University of Manitoba, Health Sciences Centre, Winnipeg, MB, - - 2013
The identification of chromosomal abnormalities in many hematopoietic and mesenchymal neoplasms has contributed significantly to classification systems. Follicular dendritic cell (FDC) sarcoma is an intermediate-grade malignancy with morphological and immunophenotypic features of follicular dendritic cells. Available data on genetic changes in this neoplasm are limited, with only isolated case reports ...
Chaouche-Mazouni Siham S Department of Biology, Kouba High School, Algiers, - - 2013
Malignant pleural mesothelioma (MPM) is an aggressive neoplasm with few treatment options. Reliable tumour cell lines for mesothelioma research are rare. Claudins seem to be attractive targets for cancer therapy. To establish a claudin-based MPM phenotype and to verify whether it is preserved in vitro and in vivo. Claudin-3 and ...
Tsiapa Georgia G Oncology Unit GPP, Sotiria General Hospital, Athens Medical School, 152 Mesogeion, Athens, 115 27, Greece. - - 2013
Smoking is related to a great variety of pathological conditions, many of which affect the respiratory system, such as lung cancer and chronic obstructive pulmonary disease (COPD). Smoking cessation should be an integral part of the therapeutic approach to patients with pulmonary disease. The objective was to provide a systematic ...
Honda Masaki - - 2013
Neutrophils are considered responsible for the pathophysiologic changes during hepatic ischemia-reperfusion (I/R) injury; however, few studies have examined real-time intravital neutrophil recruitment. Here, we show a method for imaging the neutrophil recruitment in hepatic I/R injury using two-photon laser scanning microscopy (TPLSM). LysM-eGFP mice were subjected to 45 min of ...
Cheng Ching-Hsueh - - 2013
Ischemic postconditioning (IPoC) modulates the reperfusion maneuver to mitigate ischemia-reperfusion (I/R) injury. This study aims to investigate the effects and protective mechanism of IPoC on intestinal I/R injury. Intestinal I/R was induced by occluding the superior mesenteric artery for 30 min followed by reperfusion for 60 min on male Wistar ...
Narayanan Mohanram - - 2013
Prospective data regarding immunosuppression and rejection in African American patients receiving modern immunosuppressive regimens are sparse. One-year data were analyzed from 901 tacrolimus-treated de novo kidney transplant patients in the prospective Mycophenolic Acid Observational Renal Transplant registry. Mean tacrolimus dose was significantly higher in African Americans (n=217) versus non-African Americans ...
Gaber A Osama - - 2013
This report characterizes acute rejection and rejection outcomes in subjects randomized to continuous corticosteroid therapy (CCS) or early corticosteroid withdrawal (CSWD; 7 days after transplantation) in the Astellas Blinded CSWD Trial. The Astellas Blinded CSWD Trial was a 5-year, prospective, multicenter, randomized, double-blind trial of early CCS withdrawal in 386 ...
Guethoff Sonja - - 2013
Long-term results of prospective randomized trials comparing triple immunosuppressive strategies combining tacrolimus (TAC) or cyclosporine A (CsA) with mycophenolate mofetil (MMF) and steroids after heart transplantation (HTX) are rarely published. Therefore, we collected long-term follow-up data of an intervention cohort 10 years after randomization. Ten-year follow-up data of 60 patients ...
Abd-Elgaliel Wael R WR Department of Translational Imaging, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, - - 2013
Pancreatic ductal adenocarcinoma (PDAC) is challenging to treat, and better means to detect and/or treat pancreatic cancer are urgently needed to save lives. Cathepsin E (Cath E) is a proteolytic enzyme highly expressed in PDAC. In this study, a novel approach using Cath E activation of a Cath E-specific prodrug ...
Rahimy Ehsan - - 2013
The authors report a case of nanoparticle albumin-bound paclitaxel-induced cystoid macular edema (CME) without fluorescein angiographic leakage in a patient being treated for metastatic breast cancer. The CME briskly improved 3 weeks after the chemotherapeutic agent was discontinued and was completely resolved after 6 weeks. Patients receiving taxane therapy must ...
Gerwick Michele A - - 2013
This article provides basic strategies for conducting effective meetings and providing committee chairs and members with a sense of accomplishment. Health care professionals can become easily frustrated regarding the need to attend meetings. They may perceive that attending a meeting is a waste of their valuable time, that nothing is ...
Gupta Naina - - 2013
BACKGROUND AND OBJECTIVE:To report the rates of hypotony after 25-gauge vitrectomy. PATIENTS AND METHODS:A retrospective review of 111 consecutive cases was performed in patients undergoing transconjunctival 25-gauge pars plans vitrectomy with either air or gas as a tamponade agent. The primary outcome measure was postoperative intraocular pressure less than 5 ...
Cusack Lynette - - 2013
BACKGROUND:Successful transition to practice programs that use competency-based assessment require the involvement of all staff, especially those undertaking the preceptor role. METHODS:Qualitative data were collected using interview methods. Participants were 14 newly employed nurses and 7 preceptors in the child and family community health service in South Australia. Participant narratives ...
Falkeis C - - 2013
Esophageal malformations are rare and can occur sporadically or as a component of various syndromes. The variations and classifications are manifold. With the available modern operation techniques most malformations can be resolved with good results. However, esophageal malformations are often combined with further malformations which limit the prognosis. The separation ...
Müller Mareike - - 2013
Under a variety of circumstances, melanin occurs in the dermal compartment of the skin, being mostly observed in cells that have been termed melanophages, some of which have been identified as dermal dendritic cells. We analysed changes in the expression and secretion pattern of cytokines by dendritic cells after the ...
Bock M - - 2013
Besides the relapse rate and neurological examination, magnetic resonance imaging (MRI) plays a key role in multiple sclerosis (MS) monitoring. However, MRI is costly and even in Germany not always readily available. Additionally, routine MRI scans are not sensitive enough regarding differentiation between demyelination and neurodegeneration and show a discrepancy ...
Bittinger M - - 2013
From a gastroenterological point of view, for chronic critically ill patients a differentiation has to be made between general gastroenterological problems, which are important in many or all chronic critically ill patients and patients with gastroenterological diseases which are the reason for the chronic critically ill status. General gastroenterological problems ...
Kossow A - - 2013
The highest proportion of nosocomial infections occurs on intensive care units (ICU) and infections with multiresistant pathogens are an ever increasing problem. Preventative measures should consist of a bundle of different measures including measures that address a specific problem and standard hygiene measures that are relevant in all areas. Specific ...
Kandulski A - - 2013
Modern functional laboratories provide various techniques for the evaluation of esophageal diseases. For proton pump inhibitor (PPI) refractory reflux symptoms the differentiation of non-erosive gastroesophageal reflux disease and functional heartburn is essential for the choice of further treatment. The differentiation of the two clinical entities is based on functional diagnostic ...
Lee Mijoon M Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United - - 2013
The reactions of all seven Escherichia coli lytic transglycosylases with purified bacterial sacculus are characterized in a quantitative manner. These reactions, which initiate recycling of the bacterial cell wall, exhibit significant redundancy in the activities of these enzymes along with some complementarity. These discoveries underscore the importance of the functions ...
Tackett Sean S Division of General Internal Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, - - 2013
The physician-patient relationship is at the heart of patient care. Dr. Michael Kahn proposed a checklist of six behaviors, defining "etiquette-based medicine", as a strategy to start each encounter respectfully and improve patient-physician rapport. To assess performance of "etiquette-based medicine" in the inpatient setting. Cross-sectional observational study using time-motion techniques ...
Galindo-Moreno P - - 2013
OBJECTIVES: To assess differences in marginal bone loss around implants placed in maxillary pristine bone and implants placed following maxillary sinus augmentation over a period of 3 years after functional loading. MATERIAL AND METHODS: Two cohorts of subjects (Group 1: Subjects who received sinus augmentation with simultaneous implant placement; Group 2: ...
Wang R - - 2013
OBJECTIVES: To analyze the relationships between peri-implant conditions and periodontal conditions in Chinese patients with dental implants in place for at least 1 year. MATERIAL AND METHODS: Seventy-six patients (mean age, 41 ± 10 years; range, 21-69 years) who received placement of 120 dental implants (Straumann(®) ), (mean 1.6 implants per subject; range, 1-5 implants ...
Moyer Cheryl A - - 2013
To explore the impact of social factors on place of delivery in northern Ghana. We conducted 72 in-depth interviews and 18 focus group discussions in the Upper East Region of northern Ghana among women with newborns, grandmothers, household heads, compound heads, community leaders, traditional birth attendants, traditional healers, and formally ...
Ménard Gabriel - - 2013
Reactions of amine-boranes NH(3)BH(3), Me(2)NHBH(3), or Me(3)NBH(3) with AlX(3) (X = Cl, Br, I, C(6)F(5)) have been examined. The species AlBr(3)·H(3)BNMe(3), Al(C(6)F(5))(3)·H(3)BNMe(3), Al(C(6)F(5))(3)·H(3)BNHMe(2) and Al(C(6)F(5))(3)·H(3)BNH(3) have been prepared and isolated. The analogous reaction of B(C(6)F(5))(3) and H(3)BNMe(3) results in C(6)F(5)-transfer and the formation of (C(6)F(5))BH(2)·NMe(3). While the adduct was unreactive ...
Bonnet Céline - - 2013
Intellectual disability (ID) is a clinical sign reflecting diverse neurodevelopmental disorders that are genetically and phenotypically heterogeneous. Just recently, partial or complete deletion of methyl-CpG-binding domain 5 (MBD5) gene has been implicated as causative in the phenotype associated with 2q23.1 microdeletion syndrome. In the course of systematic whole-genome screening of ...
Bitzer Johannes - - 2013
Abstract Women using combined oral contraceptives (COCs) report hormone withdrawal-associated symptoms (HWaS), including bloating, headaches and pelvic pain, which might be due to withdrawal of exogenous hormones and fluctuations in endogenous estrogen during the hormone-free interval (HFI). The prevalence of HWaS is not yet well studied, but these symptoms may ...
Clos Mareike - - 2013
Auditory verbal hallucinations (AVH) are a hallmark of psychotic experience. Various mechanisms including misattribution of inner speech and imbalance between bottom-up and top-down factors in auditory perception potentially due to aberrant connectivity between frontal and temporo-parietal areas have been suggested to underlie AVH. Experimental evidence for disturbed connectivity of networks ...
Brusa Davide - - 2013
OBJECTIVES: A dendritic cell-based cancer vaccine has recently received Food and Drug Administration approval in the USA based on its ability to prolong the survival of prostate cancer patients with advanced disease. However, tumor-mediated immunosuppressive mechanisms might represent an obstacle to optimal performance of this therapy. We have recently shown ...
Bhambure R - - 2013
This paper describes the development of a HTPD platform for process development of chromatography steps. An assessment of the platform as a guidance tool for establishing the "characterization space" for an ion exchange chromatography step has been performed by using design of experiments (DOE). Case studies involving use of a ...
Jana Manas - - 2013
A significantly fast reaction condition for the exclusive preparation β-glycosyl thiol derivatives has been developed successfully. The reaction condition is one-step, fast, high yielding, highly stereoselective, and requires only benchtop chemicals. Further reaction of glycosyl thiol derivatives with Michael acceptors and alkylating agents furnished thioglycosides and (1,1)-thiolinked trehalose analogs.
Das Sumana - - 2013
Phenol is a common substance present in many industrial wastewaters and in nonspecific pesticides. Due to its solubility and volatility phenol is often found in marine and freshwater environment. It is lipophilic compound and has a high potential for accumulating along the trophic chain. Phenol thus is not only a ...
Saha Subhrakanti - - 2013
This work describes the development and application of a new thermal desorption technique that makes use of the Leidenfrost phenomenon in open ion sources at atmospheric pressure for direct mass spectrometric detection of ultratrace levels of illicit, therapeutic, and stimulant drugs, toxicants, and peptides (molecular weight above 1 kDa) in their ...
Crnovčić Ivana - - 2013
Streptomyces chrysomallus and Streptomyces parvulus produce novel C-demethylactinomycins besides their normal actinomycins when fed with 3-hydroxyanthranilic acid (3-HA). The 3-HA is incorporated into pentapeptide lactone precursors in competition with the regular precursor 4-methyl-3-hydroxyanthranilic acid (4-MHA). The resultant 3-HA pentapeptide lactones can condense with each other, as well as with the ...
Askari G - - 2013
Background/objective:The study was carried out to assess the relationship between nut consumption and lipid profile among Iranian adults.Subject/methods:The study was based on data from the Isfahan Healthy Heart Program across three counties in central Iran in 2007. A cross-sectional survey of 9660 randomly selected adults aged 19 years were chosen ...
Tasi Yung-Chieh - - 2013
PURPOSE: Asthenozoospermia is a major cause of male infertility. However, the molecular mechanisms underlying sperm-motility defects remain largely unknown in the majority of cases. In our previous study, we applied a proteomic approach to identify unknown proteins that were downregulated in spermatozoa with low motility compared to spermatozoa with good ...
Kapoor C S - - 2013
Plants can be used as both passive biomonitors and biomitigators in urban and industrial environments to indicate the environmental quality and to ameliorate pollution level in a locality. Many studies reveal that plants are negatively affected by the ambient levels of air pollutants. The present study was conducted to evaluate ...
Fidler Andrew F - - 2013
We present a theory for a bath model in which we approximate the adiabatic nuclear potential surfaces on the ground and excited electronic states by displaced harmonic oscillators that differ in curvature. Calculations of the linear and third-order optical response functions employ an effective short-time approximation coupled with the cumulant ...
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