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Fiacconi Chris M - - 2013
Background/Study Context: The perception of naturalistic events depends on the ability to integrate perceptual information from multiple sensory systems. Currently, little is known about how multisensory integration is affected by normal aging. Methods: The authors conducted two experiments to investigate audiovisual temporal processing in younger (18-29 years) and older (70+ ...
Fiorentini Giammaria - - 2013
Diphtheria toxin (DT) has shown anticancer activity in both experimental models and humans but its adverse effects stopped further developments. Cross-reacting Material 197 (CRM197) is the product of a single missense mutation (Gly52 to Glu) within fragment A of DT. It has been shown to induce weak toxicity in some ...
Subramanian Padmanabhan - - 2013
Significantly displaced midshaft clavicle fractures can be managed operatively to restore anatomy and allow early mobilization. Several techniques have described using precontoured anatomically designed plates placed on the superior surface of the bone or reconstruction plates contoured by the surgeon placed either superiorly or anteriorly. We describe the use of ...
Stavrakis Stavros - - 2013
: An inverse relationship between brain natriuretic peptide (BNP) levels and body mass index (BMI) has been described for patients with left ventricular (LV) systolic dysfunction. In this study, the association of BMI, BNP levels and mortality in patients hospitalized for heart failure with preserved LV systolic function (HFpLVF) was ...
Anderson Ken M - - 2013
Many types of cancers represent different forms of blocked differentiation, but the relationship with major, currently identified cancer driver mutational and epigenetic events is not well defined. Normal cellular differentiation depends upon hierarchically-organized sequences of control and synthetic events coupled with cellular proliferation. An ability to identify and possibly correct ...
Ravishankar Vinutha - - 2013
ABSTRACT: Stimulus parameters like pulse amplitude, shape, width, and train frequency exert unique neurobiological effects. Herewith, we report the case of a patient in whom seizure induction was not possible with conventional stimulus parameters using bitemporal electroconvulsive therapy. She had successful induction of seizures with reduced charge rate. This strategy ...
Woodward Joseph F - - 2013
The trapeziometacarpal joint is commonly affected by degenerative arthritis, presenting with pain, stiffness, and swelling at the base of the thumb. When conservative treatment fails, surgical intervention may be warranted based on clinical and radiologic staging as well as patient demand. The concept of replacing the trapeziometacarpal joint remains attractive ...
Okuno Masashi - - 2013
Aim: In previous animal studies, we confirmed that linoleic acid (LNA) enhanced colon carcinogenesis, whereas eicosapentaenoic acid (EPA) had protective effects in azoxymethane-induced colon tumorigenesis. In regard to the protective effects of marine n-3 polyunsaturated fatty acids (PUFAs) on colorectal cancer however, evidence from epidemiological studies is inconsistent. In the ...
Kamath Jagannath B - - 2013
Syndactyly and postburn contracture of the digits are the common cases seen in a hand clinic. Their management can be roughly divided into 3 stages. In stage 1, syndactyly/postburn contracture of the digits are surgically released; in stage 2, surgical wound care is provided; and in stage 3, the patient ...
Oliva Elizabeth M - - 2013
Background: Opioid agonist therapy (OAT) through addiction specialty clinic settings (clinic-based OAT) using methadone or buprenorphine or office-based settings using buprenorphine (office-based OAT) is an evidence-based treatment for opioid dependence. The low number of clinic-based OATs available to veterans (N = 53) presents a barrier to OAT access; thus, the expansion in ...
Sakagami Hiroshi - - 2013
Previous studies have shown antiviral, antibacterial, and anti-inflammatory activity of alkaline extract of the leaves of Sasa senanensis Rehder (SE). In order to manufacture an SE-containing toothpaste for combating oral diseases, we investigated the possible interaction between the candidate ingredients of toothpaste: SE, isopropyl methylphenol (IPMP, antibacterial agent) and charcoal ...
Kisic-Tepavcevic Darija - - 2013
Objective: The aim of this study was to assess alcohol drinking patterns and its influence on health-related quality of life (HRQoL) among the Belgrade University students. Methods: Between April and June, 2009, 1624 students were enrolled in the cross-sectional study. All participants in the study completed the questionnaire that comprised ...
Passadaki Theoktisti - - 2013
Background/Aim: Binding of FAS ligand (FASL) to its physiological receptor FAS, induces the activation of caspase-8, which triggers cell death. The FAS-FASL system regulates germ cell death. In this study, the role of the FAS-FASL system in male infertility was examined. 72 samples were used (age=38.76±9.06 years). Basic semen analysis ...
Harrington Anthony W - - 2013
The specialized architecture of neurons necessitates unique modes of intracellular communication to allow for cell survival, the ability to detect and respond to injury and aspects of neuronal development, such as axon and dendrite growth, plasticity, and synapse and circuit formation. Many of these neuronal processes rely on signal transduction ...
Biswas Debashis - - 2013
Two long sewerage canals in the city of Kolkata, India were heavily infested with larvae, pupae and egg rafts of the mosquito Culex quinquefasciatus. Although the burden of bancroftian filariasis and other diseases transmitted by C. quinquefasciatus in the city is practically zero, the night-biting mosquitoes are a great nuisance ...
Ty Melissa - - 2013
Few studies have examined potential intermediary processes linking insecure attachment with eating disorders. The purpose of this study was to compare the relative contributions of social comparison and emotion dysregulation on disordered eating symptoms within an attachment framework. Participants were 247 women living in Australia, aged between 18 and 35 ...
Ross Clint - - 2013
Amobarbital is used at our institution to treat patients with significant pre-electroconvulsive therapy (ECT) anxiety/agitation. The primary objective of this study was to determine whether amobarbital pretreatment has an impact on duration of seizures. Charts of patients receiving ECT were retrospectively reviewed for demographics,number of treatments, and seizure duration. Pretreatment ...
Bloch-Teitelbaum Alexandra - - 2013
Objectives: To describe clinical effects, circumstances of occurrence, management and outcomes of cases of inadvertent administration of medications by an incorrect parenteral route. Methods: Retrospective single-center consecutive review of parenteral route errors of medications, reported to our center between January 2006 and June 2010. We collected demographic data and information ...
Gruettner Joachim - - 2013
Although complex scores were recommended for diagnosis of pulmonary embolism (PE), acceptance in clinical practice is limited. In our Emergency Department a symptom-based algorithm for patients with suspected PE including computed tomographic pulmonary angiography (CTPA) and D-dimer testing was implemented. The cases of 492 patients presenting with either chest pain, ...
Sofka Carolyn M - - 2013
Foot and ankle procedures are commonly performed most often in the setting of trauma or for realignment such as hallux valgus or acquired adult flatfoot deformity correction. Complications of these procedures occur not infrequently and therefore diagnostic imaging of the postoperative foot and ankle is often needed. Magnetic resonance imaging ...
Gangatharam Sudhagar - - 2013
Extensor tendon injuries are given less importance than the flexor tendon injuries; however, the extensor mechanism is more complicated than flexor tendon system, and regaining satisfactory function is a challenge. It has been reported that loss of digital flexion would affect grasp and power grip imposing greater functional loss than ...
Berg John Erik - - 2013
Severe unipolar or bipolar depression is often not helped by pharmacotherapy and/or psychotherapeutic treatment alone, whereas more than 80% of these patients remit after sessions of electroconvulsive treatment (ECT). Getting patients back to work after a severe depression may be important for maintaining the effect of ECT. Twenty consecutive patients ...
Siegling Alexander B - - 2013
This study examined the relationships between body image importance (BII) and perfectionism and body satisfaction in a Canadian sample of undergraduate students. Specifically, perfectionism was conceptualized as a common cause of BII and body satisfaction. Furthermore, gender-schematic processing was examined as a moderator of sex differences in BII, which have ...
Wu Guomin - - 2013
The primary objective of this study was to examine ezrin in the CD44(+) subpopulation of SCC-9 cells in a malignant oral cancer cell line. The CD44(+) subpopulation of SCC-9 cells was sorted using CD44 fluorescence-activated cell sorting flow cytometry. Expressions of the ABCG2, CD133, Oct-4, BMI-1, an ezrin genes and ...
Vaiopoulos Aristeidis G - - 2013
The invasive procedures amniocentesis and chorionic villus sampling are routinely applied in pregnancies at risk for fetal genetic disorders and the results obtained are the gold standard for prenatal diagnosis. These procedures have an approximately 0.5-1% risk for fetal loss and are mainly used in cases at risk for fetal ...
Postaci Aysun - - 2013
ABSTRACT: A 51-year-old male patient with a diagnosis of refractory major depressive disorder and unresponsive to antidepressants underwent 8 sessions of electroconvulsive therapy (ECT) every 48 hours. Succinylcholine was used for muscle relaxation until the sixth ECT session, and midazolam was administered for severe emergence agitation that recurred after each ...
Bain Gregory I - - 2013
Eight patients underwent scapholunate reconstruction using tensionable suture anchors. Adapted from a modified Brunelli technique, the anchors provide a fixed cable that reduces the scapholunate diastasis and maintains reduction during the healing phase. The flexor carpi radialis tendon graft is advanced through the scaphoid and stabilizes the volar scaphotrapezial ligament, ...
Gunarajah Dharmindra Rajah - - 2013
To evaluate the reported use and outcomes of implant materials used for the restoration of post-traumatic orbital floor defects in adults. A systematic search of the English literature was performed in the databases of PubMed, Cochrane Library, and EMBASE. The study selection process was adapted from the PRISMA (Preferred Reporting ...
Taylor Linnéa - - 2013
To explore the effect of lateral tension as a survival factor for retinal explants in vitro. The central nervous system (CNS) resides in a highly mechanical milieu. However, the importance of biomechanical homeostasis for normal CNS function has not been extensively explored. Diseases in which normal mechanical forces are disrupted, ...
Lavinsky Daniel - - 2013
To develop a method for modulation of transgene expression in retinal pigment epithelium (RPE) using scanning laser that spares neurosensory retina. Fifteen pigmented rabbits received subretinal injection of recombinant adeno-associated virus (rAAV-2) encoding green fluorescent protein (GFP). GFP expression was measured using confocal scanning laser ophthalmoscopy (cSLO) fluorescence imaging and ...
Lee Kyoung Sub - - 2013
To assess the reproducibility of circumpapillary retinal nerve fiber layer thickness (cRNFLT) and total macular thickness (TMT) parameters using Cirrus spectral domain optical coherence tomography (SD-OCT) and to apply this information to investigate its ability to detect cases where visual field (VF) progression was noted on event-based analysis in the ...
Hawthorne Felicia - - 2013
Myopia, or nearsightedness, is a common ocular genetic disease for which over 20 candidate genomic loci have been identified. The high-grade myopia locus, MYP3, has been reported on chromosome 12q21-23 by four independent linkage studies. We performed a genetic association study of the MYP3 locus in a family-based high-grade myopia ...
Yang Xu - - 2013
To develop a mouse model of inducible, chronic retinal ganglion cell (RGC) dysfunction not associated with cell death. Eighteen C57BL/6J mice were longitudinally tested with pattern electroretinogram (PERG) and spectral-domain optical coherence tomography (OCT) before and after aspiration of the contralateral superior colliculus (SC), which removed terminals of optic tract ...
Janssen Katherine T - - 2013
Retinal ganglion cells atrophy during the execution of the intrinsic apoptotic program. This process, which has been termed the apoptotic volume decrease (AVD) in other cell types, has not been well-characterized in ganglion cells. Acute optic nerve crush was used to examine neuronal atrophy in the ganglion cell layer in ...
Kuchtey John - - 2013
Previously, we mapped the disease locus in the beagle model of autosomal recessive primary open angle glaucoma (POAG) to a 4-Mb interval on chromosome 20, and identified a Gly661Arg variant in ADAMTS10 as the candidate disease-causing variant. The purpose of this study was to test the hypothesis that the Gly661Arg ...
Swaminathan Swarup S - - 2013
Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein known to regulate extracellular matrix (ECM) in many tissues and is highly expressed in trabecular meshwork (TM). SPARC-null mice have a 15% to 20% decrease in intraocular pressure (IOP) compared to wild-type (WT) mice. We hypothesized that mouse ...
De Meirleir Kenny L - - 2013
Myalgic encephalomyelitis (ME) is a debilitating illness of unknown etiology characterized by neurocognitive dysfunction, inflammation, immune abnormalities and gastrointestinal distress. An increasing body of evidence suggests that disruptions in the gut may contribute to the induction of neuroinflammation. Therefore, reports of human endogenous retroviral (HERV) expression in association with neuroinflammatory ...
Scheen André J - - 2013
Metformin is the first-choice drug in the management of type 2 diabetes. However, most patients require a combined therapy to reach and/or maintain targets of glucose control. Dipeptidyl peptidase-4 (DPP-4) inhibitors offer new options for combined therapy with metformin. Linagliptin shares a similar pharmacodynamic (PD) profile with other gliptins, but ...
Murphy Kate - - 2013
Detailed information regarding the causes and treatment of acute collapse in the cat can be difficult to locate in a single published source. This two-part review aims to provide a logical approach to the clinical assessment and stabilisation of the critically ill collapsed cat. Laboratory evaluation, in the form of ...
Murphy Kate - - 2013
Detailed information regarding the causes and treatment of acute collapse in the cat can be difficult to locate in a single published source. This two-part review aims to provide a logical approach to the clinical assessment and stabilisation of the critically ill collapsed cat. Cats are particularly challenging when presented ...
Little Susan - - 2013
Orphaned kittens are common and veterinary team members should be prepared to assist owners in providing appropriate care. If a foster queen is not available, the physiologic needs normally provided by the queen, such as warmth, nutrition, elimination, sanitation and social stimulation, must be replaced. Specialized knowledge of physiology and ...
Woodbridge Nicolas - - 2013
Mandibular fractures occur commonly in cats and appropriate treatment is vital to ensure restoration of dental occlusion and masticatory function. Historically, a relatively high complication rate has been reported in association with mandibular fracture repair, and these complications can represent a significant challenge for the veterinary surgeon. General practitioners as ...
Vila-Rodriguez Fidel - - 2013
The presence of rhythmic electroencephalographic artifacts may at times be confused with actual brain-related activity even before electroconvulsive therapy. Here, we present a case of rapid persistent blinking due to tardive dyskinesia, causing rhythmic deltalike artifacts on the electroencephalographic monitor.
McKown Robert L RL Department of Integrated Science and Technology, James Madison University, Harrisonburg, VA, - - 2013
Lacritin is a prosecretory mitogen in tears and, although a tear protein, it promotes basal tearing and lacrimal gland secretion. Since scale up is relevant to its potential use in the treatment of dry eye, we explored various mutagenic strategies to alter the stability, solubility, and translational efficiency of nascent ...
Awadalla Mona S MS Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia. - - 2013
Recently, several studies have investigated genetic associations between Cytochrome P450 (CYP1B1), Endothelial nitric oxide synthase (eNOS), and Neurotrophin-4 (NTF4) with primary angle-closure glaucoma (PACG) in various ethnic groups. We investigated the association of these candidate genes with PACG in samples from Australia and Nepal. A total of 235 patients with ...
Mahoney Emilia E Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus, OH, - - 2013
Chronic lymphocytic leukemia (CLL) is a mature B cell malignancy and is the most prevalent type of leukemia in adults. There is no curative therapy for this disease; however, several new agents have shown very promising results. Autophagy has not been studied in CLL and in this study we first ...
Venkatesh Sudhakar K SK Diagnostic Radiology, National University of Singapore, - - 2013
Many pathological processes cause marked changes in the mechanical properties of tissue. MR elastography (MRE) is a noninvasive MRI based technique for quantitatively assessing the mechanical properties of tissues in vivo. MRE is performed by using a vibration source to generate low frequency mechanical waves in tissue, imaging the propagating ...
Diallo Diawo D Unité d'Entomologie Médicale, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220, Dakar, - - 2013
Dengue (DENV), yellow fever (YFV) and chikungunya (CHIKV) viruses circulate in sylvatic, enzootic transmission cycles in southeastern Senegal, but understanding of the vector-host interactions involved is limited. The vertebrate hosts of several potential mosquito vectors of the three viruses were identified by PCR amplification and sequencing portions of the cytochrome ...
Pinto Bernardine M BM Centers for Behavioral and Preventive Medicine, Miriam Hospital, Providence, RI 02903, USA. - - 2013
Maintenance of exercise after completing phase II cardiac rehabilitation (CR) is challenging for many patients. We offered a telephone-based maintenance intervention and found improvement in exercise participation in the intervention group at 12 months post-CR discharge. We examined the effects of the intervention on psychosocial outcomes. The effects of a ...
Lublin Fred D FD Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Department of Neurology, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. - - 2013
A double-blind, randomized, controlled study was undertaken to determine whether combined use of interferon β-1a (IFN) 30 μg intramuscularly weekly and glatiramer acetate (GA) 20 mg daily is more efficacious than either agent alone in relapsing-remitting multiple sclerosis. A total of 1,008 participants were randomized and followed until the last ...
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