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Scheen André J - - 2013
Metformin is the first-choice drug in the management of type 2 diabetes. However, most patients require a combined therapy to reach and/or maintain targets of glucose control. Dipeptidyl peptidase-4 (DPP-4) inhibitors offer new options for combined therapy with metformin. Linagliptin shares a similar pharmacodynamic (PD) profile with other gliptins, but ...
Pálföldi Regina - - 2013
Pulmonary epithelioid haemangioendothelioma is a rare endothelial tumour without standard treatment. For this reason, our aim is to present contemporary research outlining new therapeutic possibilities; thus in vitro and in vivo methods were combined. Pulmonary epithelioid haemangioendothelioma was diagnosed in a 49-year-old female patient. A bronchial excision was obtained from ...
Dewhurst Catherine - - 2013
In recent years, magnetic resonance imaging (MRI) has become a valuable diagnostic tool for evaluation of acute abdominal pain in pregnancy. MRI offers an opportunity to identify the normal or inflamed appendix as well as a variety of other pathologic conditions that can masquerade clinically as acute appendicitis in pregnant ...
Julien Terrill P - - 2013
Surgical treatment of thumb basal joint arthritis is aimed at pain relief, restoration of pinch strength, and stability. We describe a variation of the abductor pollicus longus (APL) suspension arthroplasty originally described by Thompson, which maximizes strength of repair and is technically simple to perform. The technique consists of a ...
Pinhas Leora - - 2013
Healthy eating and weight initiatives have been incorporated into many schools to combat the growing obesity problem. There is little research, however, on the effectiveness of these programs or any inadvertent harmful effects on children's mental health. Our aims were to report on how school-based healthy weights initiatives can trigger ...
Meng Huan H Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, - - 2013
We compared the cellular phenotypes and studied the role of autophagy in the pathogenesis of Fuchs endothelial corneal dystrophy (FECD) using two α2 collagen VIII (Col8a2) knock-in mouse models and human FECD tissues. In vivo corneal endothelial cell (CEC) counts and morphology were analyzed by clinical confocal microscopy. Ultrastructural analysis ...
Hartwell Karen J KJ Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA. - - 2013
Varenicline has been shown to reduce cigarette craving during a quit attempt. Use BOLD fMRI to explore differences in smoking cue reactivity at baseline and after five weeks of varenicline smoking cessation treatment. Treatment-seeking nicotine-dependent adult smokers underwent BOLD fMRI scans with block presentation of visual smoking, neutral, and rest ...
Sudzius Gintaras - - 2013
Aim: To investigate the T-helper (Th1, Th2 and Th17) cell activity in the peripheral blood of patients with primary Sjögren's syndrome (pSS), non-Sjögren's sicca syndrome (nSS) and healthy controls. Peripheral blood mononuclear cells from 34 pSS, 13 nSS patients and 13 healthy controls were stimulated, labeled for cluster of differentiation-4 ...
Iannaccone Mara - - 2013
We investigated self-injurious behaviors and body modification practices in eating disorder patients, considering different ED diagnoses and illness severities. Of the total sample, 50.9% showed at least one form of self-injury and 50.9% reported at least one tattoo, piercing, or both. Patients reporting only body modifications showed more positive feelings ...
Kisic-Tepavcevic Darija - - 2013
Objective: The aim of this study was to assess alcohol drinking patterns and its influence on health-related quality of life (HRQoL) among the Belgrade University students. Methods: Between April and June, 2009, 1624 students were enrolled in the cross-sectional study. All participants in the study completed the questionnaire that comprised ...
Passadaki Theoktisti - - 2013
Background/Aim: Binding of FAS ligand (FASL) to its physiological receptor FAS, induces the activation of caspase-8, which triggers cell death. The FAS-FASL system regulates germ cell death. In this study, the role of the FAS-FASL system in male infertility was examined. 72 samples were used (age=38.76±9.06 years). Basic semen analysis ...
Overman Amy A - - 2013
Background/Study Context: This study investigated age-related differences in memory for crime information. Older adults have been found to rely more than young adults on schema- and stereotype-based processing in memory, and such age differences may have implications in the criminal justice system. Some prior research has examined schema-based processing among ...
Perry Anamarija M AM Department of Pathology, University of Manitoba, Health Sciences Centre, Winnipeg, MB, - - 2013
The identification of chromosomal abnormalities in many hematopoietic and mesenchymal neoplasms has contributed significantly to classification systems. Follicular dendritic cell (FDC) sarcoma is an intermediate-grade malignancy with morphological and immunophenotypic features of follicular dendritic cells. Available data on genetic changes in this neoplasm are limited, with only isolated case reports ...
Okuno Masashi - - 2013
Aim: In previous animal studies, we confirmed that linoleic acid (LNA) enhanced colon carcinogenesis, whereas eicosapentaenoic acid (EPA) had protective effects in azoxymethane-induced colon tumorigenesis. In regard to the protective effects of marine n-3 polyunsaturated fatty acids (PUFAs) on colorectal cancer however, evidence from epidemiological studies is inconsistent. In the ...
Kamath Jagannath B - - 2013
Syndactyly and postburn contracture of the digits are the common cases seen in a hand clinic. Their management can be roughly divided into 3 stages. In stage 1, syndactyly/postburn contracture of the digits are surgically released; in stage 2, surgical wound care is provided; and in stage 3, the patient ...
Gunarajah Dharmindra Rajah - - 2013
To evaluate the reported use and outcomes of implant materials used for the restoration of post-traumatic orbital floor defects in adults. A systematic search of the English literature was performed in the databases of PubMed, Cochrane Library, and EMBASE. The study selection process was adapted from the PRISMA (Preferred Reporting ...
Kelly Brian C - - 2013
Background: Methamphetamine use has emerged in China over the past decade. With the growth in methamphetamine use, it remains uncertain how users in China perceive its association with the HIV epidemic. Methods: The authors utilize qualitative and survey data from a mixed-methods study on methamphetamine use and HIV risk in ...
Koh Teho - - 2013
We recently reported that eugenol exerted comparable cytotoxicity towards human normal and tumor cells. In the present study, we investigated the effect of eugenol on interleukin-8 (IL-8) production by IL-1β-stimulated oral cells. The viable cell number was determined by direct cell counting with a hemocytometer after trypsinization. IL-8 released into ...
Salverda Joanne G W - - 2013
Background. Cosmetic products contribute considerably to the incidence of contact dermatitis. In response to a resolution of the Council of Europe, the National Institute for Public Health and the Environment (RIVM) in The Netherlands set up a pilot project to report undesirable effects attributed to cosmetic products. Objectives. To provide ...
Landeck Lilla - - 2013
Background. Loss-of-function mutations in the filaggrin gene (FLG) have been reported to be associated with specific phenotypic characteristics such as hyperlinearity and keratosis pilaris. Objectives. To study phenotypic features in patients with occupational irritant contact eczema of the hands in relation to FLG loss-of-function mutations. Materials and methods. In a ...
Little Susan - - 2013
Orphaned kittens are common and veterinary team members should be prepared to assist owners in providing appropriate care. If a foster queen is not available, the physiologic needs normally provided by the queen, such as warmth, nutrition, elimination, sanitation and social stimulation, must be replaced. Specialized knowledge of physiology and ...
Lee Kyoung Sub - - 2013
To assess the reproducibility of circumpapillary retinal nerve fiber layer thickness (cRNFLT) and total macular thickness (TMT) parameters using Cirrus spectral domain optical coherence tomography (SD-OCT) and to apply this information to investigate its ability to detect cases where visual field (VF) progression was noted on event-based analysis in the ...
Lenoble Quentin - - 2013
Background/Study Context: The authors assessed whether age-related changes in low-level vision affects higher-level processes involved in object categorization. Methods: Thirty young and 30 older observers were asked to categorize gray levels photographs of natural and artifactual objects. The authors manipulated contrast (8% vs. 30%) and eccentricity (central vs. 21° peripheral ...
De Meirleir Kenny L - - 2013
Myalgic encephalomyelitis (ME) is a debilitating illness of unknown etiology characterized by neurocognitive dysfunction, inflammation, immune abnormalities and gastrointestinal distress. An increasing body of evidence suggests that disruptions in the gut may contribute to the induction of neuroinflammation. Therefore, reports of human endogenous retroviral (HERV) expression in association with neuroinflammatory ...
Sadananda Suneetha K - - 2013
ABSTRACT: Drug-induced parkinsonism (DIP) is the second most common cause of parkinsonism in the elderly after idiopathic Parkinson disease. We report the case of an elderly man who had long-standing paranoid schizophrenia and DIP; both sets of symptoms improved with a course of 8 bilateral electroconvulsive therapies (ECTs). Improvement in ...
Fechner Maarten R - - 2013
Carpal tunnel syndrome is a common peripheral nerve disease, often requiring surgical intervention. After the first description of endoscopic carpal tunnel release 20 years ago, several endoscopic techniques have been described. The endoscopic procedure seems to have a better outcome in terms of time to return to work. A feared ...
Awadalla Mona S MS Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia. - - 2013
Recently, several studies have investigated genetic associations between Cytochrome P450 (CYP1B1), Endothelial nitric oxide synthase (eNOS), and Neurotrophin-4 (NTF4) with primary angle-closure glaucoma (PACG) in various ethnic groups. We investigated the association of these candidate genes with PACG in samples from Australia and Nepal. A total of 235 patients with ...
Chaouche-Mazouni Siham S Department of Biology, Kouba High School, Algiers, - - 2013
Malignant pleural mesothelioma (MPM) is an aggressive neoplasm with few treatment options. Reliable tumour cell lines for mesothelioma research are rare. Claudins seem to be attractive targets for cancer therapy. To establish a claudin-based MPM phenotype and to verify whether it is preserved in vitro and in vivo. Claudin-3 and ...
Venkatesh Sudhakar K - - 2013
Many pathological processes cause marked changes in the mechanical properties of tissue. MR elastography (MRE) is a noninvasive MRI based technique for quantitatively assessing the mechanical properties of tissues in vivo. MRE is performed by using a vibration source to generate low frequency mechanical waves in tissue, imaging the propagating ...
Immerman Igor - - 2013
Internal rotation contracture is the most common shoulder deformity in patients with brachial plexus birth injury. The purpose of this investigation is to describe the indications, technique, and results of the subscapularis slide procedure. The technique involves the release of the subscapularis muscle origin off the scapula, with preservation of ...
Pinto Bernardine M BM Centers for Behavioral and Preventive Medicine, Miriam Hospital, Providence, RI 02903, USA. - - 2013
Maintenance of exercise after completing phase II cardiac rehabilitation (CR) is challenging for many patients. We offered a telephone-based maintenance intervention and found improvement in exercise participation in the intervention group at 12 months post-CR discharge. We examined the effects of the intervention on psychosocial outcomes. The effects of a ...
Mahoney Emilia E Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus, OH, - - 2013
Chronic lymphocytic leukemia (CLL) is a mature B cell malignancy and is the most prevalent type of leukemia in adults. There is no curative therapy for this disease; however, several new agents have shown very promising results. Autophagy has not been studied in CLL and in this study we first ...
Niklasson Ida B - - 2013
Background. Cinnamyl alcohol and cinnamal are frequent fragrance contact allergens. Both are included in the European baseline fragrance mix I, which is used for screening of contact allergy in dermatitis patients. Objectives. The aim of this study was to investigate the autoxidation of cinnamyl alcohol and to identify the oxidation ...
Vaiopoulos Aristeidis G - - 2013
The invasive procedures amniocentesis and chorionic villus sampling are routinely applied in pregnancies at risk for fetal genetic disorders and the results obtained are the gold standard for prenatal diagnosis. These procedures have an approximately 0.5-1% risk for fetal loss and are mainly used in cases at risk for fetal ...
Postaci Aysun - - 2013
ABSTRACT: A 51-year-old male patient with a diagnosis of refractory major depressive disorder and unresponsive to antidepressants underwent 8 sessions of electroconvulsive therapy (ECT) every 48 hours. Succinylcholine was used for muscle relaxation until the sixth ECT session, and midazolam was administered for severe emergence agitation that recurred after each ...
Bain Gregory I - - 2013
Eight patients underwent scapholunate reconstruction using tensionable suture anchors. Adapted from a modified Brunelli technique, the anchors provide a fixed cable that reduces the scapholunate diastasis and maintains reduction during the healing phase. The flexor carpi radialis tendon graft is advanced through the scaphoid and stabilizes the volar scaphotrapezial ligament, ...
Lublin Fred D FD Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Department of Neurology, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. - - 2013
A double-blind, randomized, controlled study was undertaken to determine whether combined use of interferon β-1a (IFN) 30 μg intramuscularly weekly and glatiramer acetate (GA) 20 mg daily is more efficacious than either agent alone in relapsing-remitting multiple sclerosis. A total of 1,008 participants were randomized and followed until the last ...
Heffner Kathi L - - 2013
Background/Study Context: Vascular and myocardial activation can each increase blood pressure responses to stressors, but vascular responses are uniquely associated with negative affect, pernicious coping processes, and cardiovascular risk. These hemodynamic correlates of coping in response to acute stressors have not been well characterized in older adults. Methods: Adults 65 ...
Jacobsen Kirsten Rosenmaj - - 2013
The aim of the present study was to evaluate the utility of various non-invasive parameters for the prediction of tumor development and animal welfare in a murine xenograft model in male C.B-17 SCID (C.B-Igh-1(b)/IcrTac-Prkdc(scid)) mice. The study showed that body weight, food and water consumption, and an animal welfare assessment ...
Kar Sujit Kumar - - 2013
ABSTRACT: Thromboembolic phenomenon is common in pregnancy and puerperium. Thrombosis of cerebral vasculature during postpartum period may present as postpartum psychosis where catatonia may be the presenting symptoms. It is known that catatonia responds to benzodiazepines and electroconvulsive therapy. In this case report, a young woman presented with postpartum psychosis ...
Mathew Philip - - 2013
The most common complication after distal radius fractures is union with deformity. When symptomatic, distal radial malunions may require operative intervention. Numerous approaches to the distal radius have been described. Most volar approaches involve sectioning the brachioradialis and opening the first extensor compartment to permit adequate exposure. When bone graft ...
Kuchtey John - - 2013
Previously, we mapped the disease locus in the beagle model of autosomal recessive primary open angle glaucoma (POAG) to a 4-Mb interval on chromosome 20, and identified a Gly661Arg variant in ADAMTS10 as the candidate disease-causing variant. The purpose of this study was to test the hypothesis that the Gly661Arg ...
Nirogi Ramakrishna R Department of ADME, Discovery Research, Suven Life Sciences Ltd ., Hyderabad - 500055, India. - - 2013
Epidemiologic studies and clinical assessment of schizophrenic population have revealed a high incidence of overlap between schizophrenia and addictive disorders. The aim of the present investigation was to study the effect of aripiprazole in a preclinical animal model of chronic alcohol self-administration (CASA) and also to evaluate the influence of ...
Maruschke Matthias - - 2013
Background and Aim: The objective of this study was to establish a rat model to develop hypertrophic fibrosis for subsequent safe application of ureteral stents in order to investigate new treatment options for ureteral strictures. Thirty-two male Sprague-Dawley rats were used. Group 1: Sham surgery; group 2: surgery with uretero-ureteral ...
Bloch-Teitelbaum Alexandra - - 2013
Objectives: To describe clinical effects, circumstances of occurrence, management and outcomes of cases of inadvertent administration of medications by an incorrect parenteral route. Methods: Retrospective single-center consecutive review of parenteral route errors of medications, reported to our center between January 2006 and June 2010. We collected demographic data and information ...
Gruettner Joachim - - 2013
Although complex scores were recommended for diagnosis of pulmonary embolism (PE), acceptance in clinical practice is limited. In our Emergency Department a symptom-based algorithm for patients with suspected PE including computed tomographic pulmonary angiography (CTPA) and D-dimer testing was implemented. The cases of 492 patients presenting with either chest pain, ...
Sofka Carolyn M - - 2013
Foot and ankle procedures are commonly performed most often in the setting of trauma or for realignment such as hallux valgus or acquired adult flatfoot deformity correction. Complications of these procedures occur not infrequently and therefore diagnostic imaging of the postoperative foot and ankle is often needed. Magnetic resonance imaging ...
Gangatharam Sudhagar - - 2013
Extensor tendon injuries are given less importance than the flexor tendon injuries; however, the extensor mechanism is more complicated than flexor tendon system, and regaining satisfactory function is a challenge. It has been reported that loss of digital flexion would affect grasp and power grip imposing greater functional loss than ...
Kaushik Reshma - - 2013
Acute kidney injury (AKI) is a serious complication of Plasmodium vivax malaria, worsening its prognosis. This prospective study assessed the incidence, clinical spectrum, prognostic factors and outcome of AKI in P. vivax malaria. During 2010-2011, 195 patients with vivax malaria diagnosed by positive peripheral blood film and rapid malaria test ...
Berg John Erik - - 2013
Severe unipolar or bipolar depression is often not helped by pharmacotherapy and/or psychotherapeutic treatment alone, whereas more than 80% of these patients remit after sessions of electroconvulsive treatment (ECT). Getting patients back to work after a severe depression may be important for maintaining the effect of ECT. Twenty consecutive patients ...
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