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Lübben Wolger - - 2013
Immunoglobulin E (IgE) production is tightly regulated at the cellular and genetic levels and is believed to be central to allergy development. At least two cellular pathways exist that lead to systemic anaphylaxis reactions in vivo: IgE-sensitized mast cells and IgG1-sensitized basophils. Passive anaphylaxis, by application of allergen and allergen-specific ...
Ito Shosuke S Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Japan. - - 2013
Although photodegradation of the retinal pigment epithelium (RPE) melanin may contribute to the etiology of age-related macular degeneration, the molecular mechanisms of this phenomenon and the structural changes of the modified melanin remain unknown. Recently, we found that the ratio of pyrrole-2,3,4,5-tetracarboxylic acid (PTeCA) to pyrrole-2,3,5-tricarboxylic acid (PTCA) is a ...
Sandiego Christine M CM Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06520, USA. - - 2013
Detecting changes in receptor binding at the metabotropic glutamate receptor 5 (mGluR5) with the PET allosteric antagonist, [¹¹C]ABP688, may be valuable for studying dysfunctional glutamate transmission associated with psychiatric illnesses. This study was designed to validate the findings of a recent pilot study in baboons which reported a significant global ...
Dearden Albert K AK Department of Physics, Applied Physics, and Astronomy, Rensselaer Polytechnic Institute, Troy, New York 12180, - - 2013
Protein splicing is an autocatalytic process where an "intein" self-cleaves from a precursor and ligates the flanking N- and C-"extein" polypeptides. Inteins occur in all domains of life and have myriad uses in biotechnology. Although the reaction steps of protein splicing are known, mechanistic details remain incomplete, particularly the initial ...
Tian Jie - - 2013
Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play a major role in tumor-induced immunosuppression, which hampers effective immuno-therapeutic approaches. β-Glucans have been reported to function as potent immuno-modulators to stimulate innate and adaptive immune responses, which contributes to their antitumor property. Here, we investigated the effect of particulate ...
Vroegindeweij Eric - - 2013
Leucine-rich repeat-containing G protein-coupled receptor (Lgr)5 is a marker for epithelial stem cells in the adult intestine of mice. Lgr5 transcripts have also been detected in the developing murine thymus, leading to speculation that Lgr5 is a marker for the long-sought stem cell of the thymus. To address the nature ...
Steinbrenner Holger H Institute for Biochemistry and Molecular Biology I, Heinrich-Heine-University, Düsseldorf, - - 2013
Adequate and supranutritional selenium (Se) intake, maintaining full expression of selenoproteins, has been assumed to be beneficial for human health with respect to prevention of cancer. Strikingly, the effectiveness of dietary Se supplementation depends on many factors: baseline Se status, age, gender, and genetic background of an individual; type of ...
Aracri Patrizia P Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano 20126, - - 2013
We studied how nicotinic acetylcholine receptors (nAChRs) regulate glutamate release in the secondary motor area (Fr2) of the dorsomedial murine prefrontal cortex, in the presence of steady agonist levels. Fr2 mediates response to behavioral situations that require immediate attention and is a candidate for generating seizures in the frontal epilepsies ...
Chen Chiao-Chen CC Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United - - 2013
Elucidation of epithelial transport across transcellular or paracellular pathways promises to advance the present understanding of ion transport and enables regulation of cell junctions critical to the cell and molecular biology of the epithelium. Here, we demonstrate a new instrumental technique, potentiometric scanning ion conductance microscopy (P-SICM), that utilizes a ...
Canagarajah Bertram J BJ Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, - - 2013
The clathrin-associated adaptor protein (AP) complexes AP-1 and AP-2 are two members of a family of heterotetrameric assemblies that connect transmembrane protein cargo to vesicular coats. Cargo binding by AP-1 is activated by the small GTPase Arf1, while AP-2 is activated by the phosphoinositide PI(4,5)P₂. The structures of both AP-1 ...
Pei Ying Y Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109, - - 2013
Plasmodium falciparum (Pf) blood stages express falstatin, an inhibitor of cysteine proteases (ICP), which is implicated in regulating proteolysis during red blood cell infection. Recent data using the Plasmodium berghei rodent malaria model suggested an additional role for ICP in the infection of hepatocytes by sporozoites and during liver-stage development. ...
McMillan Paul J PJ Department of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Victoria, - - 2013
The human malaria parasite, Plasmodium falciparum, modifies the red blood cells (RBCs) that it infects by exporting proteins to the host cell. One key virulence protein, P. falciparum Erythrocyte Membrane Protein-1 (PfEMP1), is trafficked to the surface of the infected RBC, where it mediates adhesion to the vascular endothelium. We ...
Tocchi Autumn - - 2013
Similar to most proteinases, matrix metalloproteinases (MMP) do not recognize a consensus cleavage site. Thus, it is not surprising that, in a defined in vitro reaction, most MMPs can act on a wide range of proteins, including many extracellular matrix proteins. However, the findings obtained from in vivo studies with genetic models ...
Kim Sung Joon SJ Department of Chemistry and Biochemistry, Baylor University, Waco, Texas 76798, United - - 2013
Plusbacin-A3 (pb-A3) is a cyclic lipodepsipeptide that exhibits antibacterial activity against multidrug-resistant Gram-positive pathogens. Plusbacin-A3 is thought not to enter the cell cytoplasm, and its lipophilic isotridecanyl side chain is presumed to insert into the membrane bilayer, thereby facilitating either lipid II binding or some form of membrane disruption. Analogues ...
Ong Ta-Chung TC Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, - - 2013
Dynamic nuclear polarization (DNP) of amorphous and crystalline ortho-terphenyl (OTP) in the absence of glass forming agents is presented in order to gauge the feasibility of applying DNP to pharmaceutical solid-state nuclear magnetic resonance experiments and to study the effect of intermolecular structure, or lack thereof, on the DNP enhancement. ...
Alharthi Sarah A SA Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas 78249, United - - 2013
This work describes a simple, versatile, and inexpensive procedure to prepare optically transparent carbon electrodes, using proteins as precursors. Upon adsorption, the protein-coated substrates were pyrolyzed under reductive conditions (5% H2) to form ultrathin, conductive electrodes. Because proteins spontaneously adsorb to interfaces forming uniform layers, the proposed method does not ...
Koh Teho - - 2013
We have recently reported that eugenol exerted indiscriminate cytotoxicity towards normal oral cells and oral squamous cell carcinoma (OSCC) cell lines without induction of apoptosis markers. In order to investigate the underlying mechanisms of cytotoxicity induction, we investigated the effect of short-term treatment with eugenol on the metabolic profiles of ...
Namazi Hamid - - 2013
External fixation of comminuted hand fractures, especially those associated with soft-tissue injuries, is a good option and avoids several complications resulting from open surgery. Therefore, many versions of mini external fixators have been developed, including commercially fabricated implants and hand-made implants. However, these devices are costly or associated with serious ...
Coffey M Justin - - 2013
ABSTRACT: Self-injurious behaviors are common, distressing features of developmental disorders. Safe and effective therapies are needed, and the pathophysiology is not well understood. We present a young man with autism who developed self-injurious behaviors due to frontal lobe seizures that resolved with phenytoin.
Moraes Gustavo L - - 2013
This review highlights the role of delayed enhancement magnetic resonance imaging for the diagnosis of patients with nonischemic myocardial disease. The authors discuss the use of delayed enhancement for differentiation between ischemic and nonischemic myocardial disease and for narrowing the differential diagnosis when nonischemic etiologies are suspected. In addition, special ...
Rajfer Rebecca A - - 2013
Kienböck disease, first described in 1910, is osteonecrosis of the carpal lunate and has been associated with ulnar minus variance. Numerous joint leveling procedures have been developed for patients with ulnar-negative variance to decrease forces transmitted across the lunate. The basis of operative treatment is the presence or absence of ...
Lin Yu-Te - - 2013
From a recent systemic review, vascularized toe proximal interphalangeal joint (PIPJ) transfer achieved an average arc of motion (AOM) of merely 37 degrees for finger PIPJ reconstruction. Despite the technical refinement over the past 3 decades, the resulting active motion of the reconstructed joint remains unpredictable and often fraught with ...
Anderson Ken M - - 2013
Many types of cancers represent different forms of blocked differentiation, but the relationship with major, currently identified cancer driver mutational and epigenetic events is not well defined. Normal cellular differentiation depends upon hierarchically-organized sequences of control and synthetic events coupled with cellular proliferation. An ability to identify and possibly correct ...
Ravishankar Vinutha - - 2013
ABSTRACT: Stimulus parameters like pulse amplitude, shape, width, and train frequency exert unique neurobiological effects. Herewith, we report the case of a patient in whom seizure induction was not possible with conventional stimulus parameters using bitemporal electroconvulsive therapy. She had successful induction of seizures with reduced charge rate. This strategy ...
Woodward Joseph F - - 2013
The trapeziometacarpal joint is commonly affected by degenerative arthritis, presenting with pain, stiffness, and swelling at the base of the thumb. When conservative treatment fails, surgical intervention may be warranted based on clinical and radiologic staging as well as patient demand. The concept of replacing the trapeziometacarpal joint remains attractive ...
Swaminathan Swarup S - - 2013
Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein known to regulate extracellular matrix (ECM) in many tissues and is highly expressed in trabecular meshwork (TM). SPARC-null mice have a 15% to 20% decrease in intraocular pressure (IOP) compared to wild-type (WT) mice. We hypothesized that mouse ...
Fiacconi Chris M - - 2013
Background/Study Context: The perception of naturalistic events depends on the ability to integrate perceptual information from multiple sensory systems. Currently, little is known about how multisensory integration is affected by normal aging. Methods: The authors conducted two experiments to investigate audiovisual temporal processing in younger (18-29 years) and older (70+ ...
Fiorentini Giammaria - - 2013
Diphtheria toxin (DT) has shown anticancer activity in both experimental models and humans but its adverse effects stopped further developments. Cross-reacting Material 197 (CRM197) is the product of a single missense mutation (Gly52 to Glu) within fragment A of DT. It has been shown to induce weak toxicity in some ...
Subramanian Padmanabhan - - 2013
Significantly displaced midshaft clavicle fractures can be managed operatively to restore anatomy and allow early mobilization. Several techniques have described using precontoured anatomically designed plates placed on the superior surface of the bone or reconstruction plates contoured by the surgeon placed either superiorly or anteriorly. We describe the use of ...
Oliva Elizabeth M - - 2013
Background: Opioid agonist therapy (OAT) through addiction specialty clinic settings (clinic-based OAT) using methadone or buprenorphine or office-based settings using buprenorphine (office-based OAT) is an evidence-based treatment for opioid dependence. The low number of clinic-based OATs available to veterans (N = 53) presents a barrier to OAT access; thus, the expansion in ...
Sakagami Hiroshi - - 2013
Previous studies have shown antiviral, antibacterial, and anti-inflammatory activity of alkaline extract of the leaves of Sasa senanensis Rehder (SE). In order to manufacture an SE-containing toothpaste for combating oral diseases, we investigated the possible interaction between the candidate ingredients of toothpaste: SE, isopropyl methylphenol (IPMP, antibacterial agent) and charcoal ...
Yang Xu - - 2013
To develop a mouse model of inducible, chronic retinal ganglion cell (RGC) dysfunction not associated with cell death. Eighteen C57BL/6J mice were longitudinally tested with pattern electroretinogram (PERG) and spectral-domain optical coherence tomography (OCT) before and after aspiration of the contralateral superior colliculus (SC), which removed terminals of optic tract ...
Stavrakis Stavros - - 2013
: An inverse relationship between brain natriuretic peptide (BNP) levels and body mass index (BMI) has been described for patients with left ventricular (LV) systolic dysfunction. In this study, the association of BMI, BNP levels and mortality in patients hospitalized for heart failure with preserved LV systolic function (HFpLVF) was ...
Wu Guomin - - 2013
The primary objective of this study was to examine ezrin in the CD44(+) subpopulation of SCC-9 cells in a malignant oral cancer cell line. The CD44(+) subpopulation of SCC-9 cells was sorted using CD44 fluorescence-activated cell sorting flow cytometry. Expressions of the ABCG2, CD133, Oct-4, BMI-1, an ezrin genes and ...
Jarzabek Monika A - - 2013
AbstractGlioblastoma multiforme (GBM), the most aggressive brain malignancy, is characterized by extensive cellular proliferation, angiogenesis, and single-cell infiltration into the brain. We have previously shown that a xenograft model based on serial xenotransplantation of human biopsy spheroids in immunodeficient rodents maintains the genotype and phenotype of the original patient tumor. ...
Obeid Nicole - - 2013
This study explored symptoms of social anxiety and multidimensional self-esteem in a clinical, adolescent female eating disorder population. Using self-report measures, data from 344 females revealed significant negative relationships between dimensions of self-esteem and social anxiety. A diagnostic difference emerged, with the restricting subgroup reporting significantly higher perceived physical appearance ...
Bülbül Feridun - - 2013
ABSTRACT: Despite having been previously associated with schizophrenia, catatonia is more often associated with mood disorders and factors related to general medical conditions. Benzodiazepines are recommended as the first option in treatment of catatonia. For patients who do not sufficiently respond to benzodiazepines and for patients that need a fast ...
Marom Edith M - - 2013
Thymoma is the most common primary neoplasm of the anterior mediastinum, but it accounts for <1% of all adult malignancies. It is the most common of the thymic epithelial neoplasms, which, in addition to thymoma, include thymic carcinoma and thymic carcinoid. Because of the rarity of thymoma, it has not ...
Lavinsky Daniel - - 2013
To develop a method for modulation of transgene expression in retinal pigment epithelium (RPE) using scanning laser that spares neurosensory retina. Fifteen pigmented rabbits received subretinal injection of recombinant adeno-associated virus (rAAV-2) encoding green fluorescent protein (GFP). GFP expression was measured using confocal scanning laser ophthalmoscopy (cSLO) fluorescence imaging and ...
McKown Robert L RL Department of Integrated Science and Technology, James Madison University, Harrisonburg, VA, - - 2013
Lacritin is a prosecretory mitogen in tears and, although a tear protein, it promotes basal tearing and lacrimal gland secretion. Since scale up is relevant to its potential use in the treatment of dry eye, we explored various mutagenic strategies to alter the stability, solubility, and translational efficiency of nascent ...
Murphy Kate - - 2013
Detailed information regarding the causes and treatment of acute collapse in the cat can be difficult to locate in a single published source. This two-part review aims to provide a logical approach to the clinical assessment and stabilisation of the critically ill collapsed cat. Laboratory evaluation, in the form of ...
Diallo Diawo D Unité d'Entomologie Médicale, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220, Dakar, - - 2013
Dengue (DENV), yellow fever (YFV) and chikungunya (CHIKV) viruses circulate in sylvatic, enzootic transmission cycles in southeastern Senegal, but understanding of the vector-host interactions involved is limited. The vertebrate hosts of several potential mosquito vectors of the three viruses were identified by PCR amplification and sequencing portions of the cytochrome ...
Taylor Linnéa - - 2013
To explore the effect of lateral tension as a survival factor for retinal explants in vitro. The central nervous system (CNS) resides in a highly mechanical milieu. However, the importance of biomechanical homeostasis for normal CNS function has not been extensively explored. Diseases in which normal mechanical forces are disrupted, ...
Jones Jermaine D JD Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. - - 2013
Although opioid substitution therapy is an effective clinical tool used to manage opioid abuse and dependence, concerns regarding the current FDA-approved medications have lead to a search for efficacious, non-opioid medications. Preclinical data indicate that neurokinin 1 (NK1) receptor activity may modulate opioid effects and withdrawal. This investigation sought to ...
Pires Isabel - - 2013
In order to investigate the immune mechanisms involved in regression of canine cutaneous histicytoma (CCH), major histocompatibility complex (MHC) class-II immuno-expression and the number of T- and B-lymphocytes and macrophages were analyzed in 93 cases of CCH. MHC class-II was also studied in 16 cases of CCH by immunoelectron microscopy. ...
Vila-Rodriguez Fidel - - 2013
The presence of rhythmic electroencephalographic artifacts may at times be confused with actual brain-related activity even before electroconvulsive therapy. Here, we present a case of rapid persistent blinking due to tardive dyskinesia, causing rhythmic deltalike artifacts on the electroencephalographic monitor.
Harrington Anthony W - - 2013
The specialized architecture of neurons necessitates unique modes of intracellular communication to allow for cell survival, the ability to detect and respond to injury and aspects of neuronal development, such as axon and dendrite growth, plasticity, and synapse and circuit formation. Many of these neuronal processes rely on signal transduction ...
Janssen Katherine T - - 2013
Retinal ganglion cells atrophy during the execution of the intrinsic apoptotic program. This process, which has been termed the apoptotic volume decrease (AVD) in other cell types, has not been well-characterized in ganglion cells. Acute optic nerve crush was used to examine neuronal atrophy in the ganglion cell layer in ...
Ty Melissa - - 2013
Few studies have examined potential intermediary processes linking insecure attachment with eating disorders. The purpose of this study was to compare the relative contributions of social comparison and emotion dysregulation on disordered eating symptoms within an attachment framework. Participants were 247 women living in Australia, aged between 18 and 35 ...
Ross Clint - - 2013
Amobarbital is used at our institution to treat patients with significant pre-electroconvulsive therapy (ECT) anxiety/agitation. The primary objective of this study was to determine whether amobarbital pretreatment has an impact on duration of seizures. Charts of patients receiving ECT were retrospectively reviewed for demographics,number of treatments, and seizure duration. Pretreatment ...
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