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Matero Sanni - - 2013
The manufacturing of tablets involves many unit operations that possess multivariate and complex characteristics. The interactions between the material characteristics and process related variation are presently not comprehensively analyzed due to univariate detection methods. As a consequence, current best practice to control a typical process is to not allow process-related ...
Tonne Cathryn - - 2013
AimsThe aim of this study was to determine (i) whether long-term exposure to air pollution was associated with all-cause mortality using the Myocardial Ischaemia National Audit Project (MINAP) data for England and Wales, and (ii) the extent to which exposure to air pollution contributed to socioeconomic inequalities in prognosis.Methods and ...
Atay Musa - - 2013
Orbital penetrating injuries may cause significant harm to optic nerves and eyeball as well as to the brain and cerebral vasculature. Defining surrounding neurovascular structures by CT angiography (CTA) is important for surgical removal. We present an uncommon case of a 3-year-old child with a penetrating orbital injury caused by ...
Cruz-Silva Rodolfo - - 2013
In this work we carried out chemical oxidation studies of nitrogen-doped multiwalled carbon nanotubes (CNx-MWCNTs) using potassium permanganate in order to obtain nitrogen-doped graphene nanoribbons. Reaction parameters such as: oxidation reaction, reaction time, the oxidizer to nanotube mass ratio, and the temperature were varied and their effect carefully analyzed. The ...
Khullar Vik - - 2013
AIMS: To discuss the importance of patients' treatment goals and perceived goal attainment to better address expectations in the treatment of lower urinary tract symptoms (LUTS), including overactive bladder (OAB). METHODS: The development of the Self-Assessment Goal Achievement (SAGA) questionnaire was driven by measurement principles from the field of qualitative ...
Su Shan-Shan - - 2013
Our current marine natural product program investigated the second metabolites of an actinomycete Streptomyces cavourensis YY01-17 originating from the Antarctic ecological niche to discover potential antitumor chemical entities. Two new compounds, along with a known compound, were isolated from the ethyl acetate extract of the fermentation broth of the marine-derived ...
Senguttuvan Premkumar - - 2013
We report the direct synthesis of powder Na3Ti2(PO4)3 together with its low potential electrochemical performance and crystal structure elucidation for the reduced and oxidized phases. First principles calculations at the density functional theory level (DFT) has been performed to get further insight on the electrochemistry of Ti(IV)/Ti(III) and Ti(III)/Ti(II) redox ...
Haensig Martin - - 2013
OBJECTIVES: Conventional surgical risk scores are used to identify suitable candidates for transapical aortic valve implantation (TA-AVI) at present. However, these scores do not consider multiple high-risk conditions, including porcelain aorta, mediastinal irradiation or frailty. The aim of this study was to compare the predictive ability of the new EuroSCORE ...
Huang Juzheng - - 2013
Urine is considered an ideal biofluid for clinical investigation because it is obtained non-invasively and relatively large volumes are easily acquired. In this study, selected ion flow tube mass spectrometry (SIFT-MS) has been applied for the quantification of volatile organic compounds (VOCs) in the headspace vapor of urine samples, which ...
Santana V T - - 2013
X-band electron spin resonance (ESR) measurements have been performed on a conducting free-standing film of polyaniline plasticized and protonated with di-n-dodecyl ester of sulfosuccinic acid (DDoESSA). The magnetic field was applied parallel and perpendicular to the plane of the film. At around 75 K a transition is observed from Pauli susceptibility ...
Heh Choon Han - - 2013
Various works have been carried out in developing therapeutics against dengue. However, to date, no effective vaccine or anti-dengue agent has yet been discovered. The development of protease inhibitors is considered as a promising option, but most previous works have involved competitive inhibition. In this study, we focused on rational ...
Bloomer Richard J - - 2013
Caffeine and 1,3-dimethylamylamine (DMAA) are widely used alone and in combination with dietary supplements. No investigation has determined the safety profile of chronic intake of caffeine or DMAA, alone or in combination, within the same study design. A total of 50 young and healthy men completed 12 weeks of daily supplementation ...
Hihara Taro - - 2013
Channels responsible for slowly activating delayed-rectifier potassium current (I(Ks)) are composed of KCNQ1 and KCNE1 subunits, and these channels play a role in the repolarization of cardiac action potentials. Recently, we showed that the antihyperlipidemic drug probucol, which induces QT prolongation, decreases the I(Ks) after 24-h treatment. In the present ...
Ye Junmei - - 2013
Polypyrimidine Tract Binding Protein (PTB) regulates pre-mRNA splicing, having special relevance for determining gene expression in the differentiating muscle. We have previously shown that PTB protein abundance is progressively reduced during heart development without reduction of its own transcript. Simultaneous reduction of Histone Deacetylase (HDAC) expression prompted us to investigate ...
Rosenbaum Andrew J - - 2013
Background. Ankle fractures in diabetics are challenging to treat, and only generalized clinical guidelines specific to their treatment exist. As such, the American Orthopaedic Foot and Ankle Society (AOFAS) membership was polled regarding the management of different types of ankle fractures in this patient population. Methods. We developed a multiple-choice ...
Al-Bannay Hana - - 2013
To augment the rigor of health promotion research, this perspective article describes how cultural factors impact the outcomes of health promotion studies either intentionally or unintentionally. It proposes ways in which these factors can be addressed or controlled in designing studies and interpreting their results. We describe how variation within ...
Uchida Yoshiaki - - 2013
We have designed and synthesized a new chiral paramagnetic liquid crystalline compound with a nitroxide radical moiety showing chiral smectic A (SmA*) and C (SmC*) phases. This compound shows pretransitional layer contraction at the SmA*-to-SmC* phase transition in the cooling run. Electron paramagnetic resonance spectroscopy, X-ray diffraction analysis, and polarized ...
Ammari Zaid A - - 2013
Primary effusion lymphoma (PEL) is an uncommon non-Hodgkin lymphoma associated with human herpes virus-8 (HHV-8) that grows mainly in serous body cavities. The most common presentation of PEL is that of a young immunocompromised male with shortness of breath, as the pleural cavity is most commonly affected. Diagnosis is primarily ...
Lehnert Petr - - 2013
The methods for separation of R,S-tolterodine and R,S-methoxytolterodine enantiomers using sulfated α-, β-cyclodextrin and phosphatedγ-cyclodextrin by capillary electrophoresis in acidic background electrolyte based on Tris/phosphate pH 2.5 buffer were developed. Sulfated α- and β-cyclodextrin allow anodic detection while phosphated-γ-cyclodextrin allows only cathodic detection of the separated enantiomers. The influence of ...
Stefanick Jared F - - 2013
PEGylated liposomes are attractive pharmaceutical nanocarriers; however, literature reports of ligand-targeted nanoparticles have not consistently shown successful results. Here, we employed a multifaceted synthetic strategy to prepare peptide-targeted liposomal nanoparticles with high purity, reproducibility, and precisely controlled stoichiometry of functionalities to evaluate the role of liposomal PEG coating, peptide EG-linker ...
Le Huu Doanh - - 2013
Chronic graft-versus-host disease (cGVHD) is an increasingly frequent cause of morbidity and mortality of allogeneic hematopoietic stem cell transplantation. Sclerodermatous cGVHD (Scl-cGVHD) is characterized by fibrosis and autoimmune features resembling those of systemic sclerosis (SSc). Transplantation of B10.D2 bone marrow and splenocytes into irradiated-BALB/c mice is an established model of ...
Peinado Jesus - - 2013
Objective: Oral preexposure prophylaxis (PrEP) with antiretrovirals (ARVs) is at the forefront of biomedical HIV prevention research, and ARVs are also being tested for rectal administration to target people practicing unprotected receptive anal intercourse (URAI) and at risk of HIV infection. This study assessed the acceptability of daily oral PrEP ...
Arshad Ali - - 2013
Background: Pancreatic cancer has an extremely poor clinical outcome. Surrogate biomarkers for outcome are scarce. There is mixed evidence for the association of high mannose-binding lectin (MBL) complement activity with cancer outcomes, including reduced survival and increased infectious complications. ω-3-rich fatty acids (ω-3FA) attenuate production of proinflammatory cytokines and potentially ...
Bravatà Valentina - - 2013
Abstract HER2/neu amplification/overexpression is the only somatic mutation widely considered to be a marker of disease outcome and response to treatment in breast cancer. Pathologists have made large efforts to achieve accuracy in characterizing HER2/neu status. The introduction of transtuzumab contributed to development of additional measures to identify sensitive and ...
Fujigaya Tsuyohiko - - 2013
Toward the next generation fuel cell systems, the development of a novel electrocatalyst for the polymer electrolyte fuel cell (PEFC) is crucial to overcome the drawbacks of the present electrocatalyst. As a conductive supporting material for the catalyst, carbon nanotubes (CNTs) have emerged as a promising candidate, and many attempts ...
Oblak M L - - 2013
This study assessed the use of whole body computed tomography (CT) for the evaluation of metastasis in dogs with primary appendicular bone tumours compared to long bone survey radiography, bone scintigraphy and thoracic radiographs. Fifteen dogs were included in this pilot study. A construct reference standard was used for detection ...
Woytowish Melanie R - - 2013
OBJECTIVE:To evaluate and review the literature surrounding serotonin toxicity in patients receiving linezolid and determine the clinical relevance of this reaction.DATA SOURCES:Literature was accessed via MEDLINE/PubMed and Google Scholar (both through February 2013) using the search terms linezolid, serotonin syndrome, serotonin toxicity, and adverse reaction.STUDY SELECTION AND DATA EXTRACTION:Relevant case ...
Bao Xinhua - - 2013
AIM: The aim of this study was to identify characteristics of epilepsy in Rett syndrome (RTT), and relationships between epilepsy and genotype. METHOD: Information on 685 females with RTT recruited to the international Rett syndrome database (InterRett) with a pathogenic MECP2 mutation was obtained from family and clinician questionnaires. Individuals ...
Morotti Elena - - 2013
INTRODUCTION.: A relationship between sexual function and all body image variables has been reported. However, there are no studies analyzing the relationship between menstrual cycle, body image, and sexuality. AIM.: To evaluate clitoral changes, sexual behavior, and perceived body image during the menstrual cycle. METHODS.: Twenty-four women underwent ultrasonographic (US) ...
Hilz Max J - - 2013
BACKGROUND AND PURPOSE: Pharmacological blockade showed sympathetic origin of 0.03 to 0.15 Hz blood pressure (BP) oscillations and parasympathetic origin of 0.15 to 0.5 Hz RR-interval (RRI) oscillations, but has not been used to determine origin of cerebral blood flow velocity (CBFV) oscillations at these frequencies. This study evaluated by ...
Kueh Jui Thiang Brian - - 2013
Spiropins for SPPS: The rigid structure of an anomerically stabilised spiroketal motif enables the appendage of substituents in a fixed conformation. To assess the ability of a spiroketal motif to induce a turn structure and participate in solid-phase peptide synthesis (SPPS), an Fmoc-spiroketal amino acid was synthesised and incorporated into ...
Hosoba Soh - - 2013
OBJECTIVES: Postinfarction ventricular septal defect (VSD) is a rare, but feared, complication after acute myocardial infarction. Although numerous techniques and materials have been used, the best technique has not yet been settled upon. We present a novel technique of VSD closure through the VSD via right ventricular (RV) incision and ...
Krajcsi Attila - - 2013
Subitizing is a fast and accurate enumeration process of small sets of usually less than four objects. Several models were proposed in the literature. Critically, only pattern recognition theory suggests that subitizing performance is sensitive to the arrangement of the array. In our study, arrays of dots in random or ...
Bettridge Judy - - 2013
Abstract Lyme borreliosis is rapidly emerging in the United Kingdom, with over 1000 cases per annum now reported. Lyme borreliosis is caused by the Borrelia burgdorferi sensu lato (s.l.) group of spirochetes, which are transmitted by ixodid ticks. In the United Kingdom, Ixodes ricinus is recognized as the principal vector ...
Linthorst Josephine I - - 2013
AIMS: In patients with myelomeningocele (MMC) and coexistent scoliosis, a spinal cord transection (SC-transection) is sometimes performed before scoliosis correction to prevent traction on the myelum after stretching the spinal column. Performing a SC-transection may have positive effects on bladder function, especially in case of refractory detrusor-sphincter dyssynergia. This study ...
Unsinn Andreas - - 2013
A practical zinc insertion starting from cheap commercial zinc powder and TMPCl (1-chloro-2,2,6,6-tetramethylpiperidine) allows a fast and efficient synthesis of the zinc base TMPZnCl·LiCl under mild conditions in high yields. This base is kinetically highly active and was used for the regio- and chemoselective functionalization of dibromodiazines (pyridazines and pyrazines).
Regan R C - - 2013
Second-opinion histopathology is a common practice in human medicine to avoid unnecessary procedures, costs and to optimize therapy. Histopathology review has been recommended in veterinary oncology as well. In this prospective evaluation of 52 tumours over a 1-year period, there was diagnostic agreement between first and second opinions in 52% ...
Wei Lianhu - - 2013
In multiple sclerosis (MS), myelin basic protein (MBP), critical for the maintenance of myelin compaction and protecting against degradation, is known to contain concentrations of the noncoded amino acid, "citrulline", in abnormal proportions. Peptidyl arginine deiminase (PAD) catalyzes the post-translational citrullination of proteins via the deimination of Arg residues. In ...
Rostain Anthony - - 2013
Objective: Therapeutic goals for chronic mental disorders like major depressive disorder (MDD) and schizophrenia have evolved in parallel with the growing medical knowledge about the course and treatment of these disorders. Although the knowledge base regarding the clinical course of ADHD, a chronic psychiatric disorder, has evolved beyond symptomatic improvement ...
Hussein Ayad Ahmed - - 2013
BACKGROUND: Patients with thalassemia in developing countries have limited access to safe transfusions, regular medical care and chelation therapy. Although allogeneic hematopoietic stem cell transplantation (HSCT) can offer a curative approach, there are limited data on the use of this procedure in developing countries. PROCEDURE: Forty-four patients underwent a risk ...
Moheet A - - 2013
PURPOSE: Hypothalamic GABA signaling has been shown to regulate the hormonal response to hypoglycemia in animals. The hypothalamus is a challenging brain region for magnetic resonance spectroscopy (MRS) due to its small size and central location. To investigate the feasibility of measuring GABA in the hypothalamus in humans, ultra-high field ...
Symens Nathalie - - 2013
In cationic carrier-mediated gene delivery, the disproportional relationship between the quantity of delivered DNA and the amount of encoded protein produced is a well-known phenomenon. The numerous intracellular barriers which need to be overcome by pDNA to reach the nucleoplasm play a major role in it. In contrast to what ...
Verma Priyanka - - 2013
A case-control study was conducted to estimate the association of cartilage oligomeric matrix protein (COMP) with knee osteoarthritis (OA) and to examine the potential utility of COMP as a diagnostic and prognostic biomarker in early knee OA. The COMP levels were estimated in the blood sera of 150 subjects belonging ...
Nakata Kouki - - 2013
On the basis of the Schwinger-Keldysh formalism, we have closely investigated the temperature dependence of quantum spin pumping generated using electron spin resonance. We have clarified that three-magnon splittings excite non-zero modes of magnons and characterize the temperature dependence of quantum spin pumping generated using electron spin resonance.
Kosinski M - - 2013
ObjectiveFatigue in systemic lupus erythematosus (SLE) is burdensome and must be assessed using validated scales. Although the psychometric properties of the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) scale in SLE have been evaluated previously, its content validity in this disease remains to be evaluated. The study objective was, therefore, ...
Weng Zhe - - 2013
Maximized energy density: Controlled electrochemical charge injection (ECI) can be used for maximizing the energy density of supercapacitors (SCs). The electrode potential is tuned by the surface chemical structure of the electrode material to increase both the working voltage and the specific capacity of the SCs. As a result, the ...
Garwood Claire - - 2013
AIMS: Calcium dyshomeostasis is implicated in the pathogenesis of several neurodegenerative disorders including Alzheimer's disease. However, much of the previous research has focused on changes in neuronal calcium signaling. In a recent microarray study we identified dysregulation of several key signaling pathways including the Ca(2+) signaling pathway in astrocytes as ...
Bradbury Robert - - 2013
The impact of two model perfumes of differing degrees of hydrophobicity / hydrophilicity, linalool, LL, and phenylethanol, PE, on the solution structure of the anionic surfactant sodium dodecyl 6-benzene sulfonate, LAS-6, has been studied by small angle neutron scattering, SANS. For both types of perfume molecule a complex phase behavior ...
Udvarhelyi Anikó - - 2013
The blue light using FAD (BLUF) photosensory proteins are activated by a unique photoreaction that results in a hydrogen-bond rearrangement around the flavin chromophore. The chemical structure of the hydrogen bond switch is a long-standing debate: The two main hypotheses postulate rotation as opposed to tautomerization of a conserved glutamine ...
Liu Bin - - 2013
A chiral gold(I) complex-catalyzed highly regio- and enantioselective azo hetero-Diels-Alder reaction has been developed. The chiral gold(I) complex acting as an oxophilic Lewis acid exhibits high efficiency in the activation of urea-based diazene dienophiles. Moreover, this chiral gold catalyst also rendered a cascade intramolecular enyne metathesis/ asymmetric azo HDA reaction.
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