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Cong Weitao - - 2013
We previously demonstrated that metallothionein (MT)-mediated protection from diabetes-induced pathological changes in cardiac tissues is related to suppression of superoxide generation and protein nitration. The present study investigated which diabetes-nitrated protein(s) mediate the development of these pathological changes by identifying the panel of nitrated proteins present in diabetic hearts of ...
Shek Daniel T L - - 2013
Abstract In the field of positive youth development, there are few studies on program sustainability and the relationship between program implementation and program sustainability. Based on an in-depth case study in the Project P.A.T.H.S. in Hong Kong, this study examines the intrinsic factors and mechanisms that influence program implementation and ...
Akin Yigit - - 2013
At the 30thWorld Congress of Endourology, dietary supplement with terpene compound drug (avocado) as an expulsive therapy for ureterolithiasis came into question again. Chua et al presented a meta-analysis of "terpene compound drug as medical expulsive therapy for ureterolithiasis".1 Additionally, recently published study by Ortiz-Alvarado et al supports dietary supplements ...
Gurevich Alexey A Algorithmic Biology Laboratory, St. Petersburg Academic University, Russian Academy of Sciences, St. Petersburg, Russia. - - 2013
Limitations of genome sequencing techniques have led to dozens of assembly algorithms, none of which is perfect. A number of methods for comparing assemblers have been developed, but none is yet a recognized benchmark. Further, most existing methods for comparing assemblies are only applicable to new assemblies of finished genomes; ...
Ogikubo Junichi - - 2013
The formal replacement of one or two pyrrole groups in meso-tetraphenylporphyrin by oxazole moieties is described, generating inter alia the bacteriochlorin-type chromophores oxazolobacteriochlorins (oxabacteriochlorins) and bisoxazolobacteriochlorins (dioxabacteriochlorins). The key step is the conversion of a beta,beta' dihydroxy-functionalized pyrroline group into an oxazolone or (substituted) oxazole. Depending on the substitution pattern ...
Iverson Katherine M - - 2013
Traumatic brain injury (TBI) research among Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) veterans has focused primarily on men. We examine associations between probable deployment-related TBI and postdeployment mental and physical health symptoms separately by gender. To identify unique associations of probable TBI with health symptoms, analyses were ...
Vejarano M P - - 2013
Abstract This study compared 4 protocols for DNA extraction from homogenates of 6 different organs of cows infected with the Brucella abortus 2308 strain. The extraction protocols compared were as follows: GT (guanidine isothiocyanate lysis), Boom (GT lysis with the carrying suspension diatomaceous earth), PK (proteinase K lysis), and Santos ...
Aslan Halil - - 2013
Liver tumors seldom occur in the perinatal period. Hepatic hemangiomas are the most common tumors of the liver diagnosed during fetal and neonatal life. The diagnosis can be suspected antenatally by ultrasound and MR scan. The differential diagnosis is often challenging. While small hepatic hemangiomas are usually asymptomatic, large tumors ...
Phang James M - - 2013
Recent research suggests that chromatin-modifying enzymes are metabolic sensors regulating gene expression. Epigenetics is linked to metabolomics in response to the cellular microenvironment. Specific metabolites involved in this sensing mechanism include S-adenosylmethionine, acetyl-CoA, alphaketoglutarate and NAD (+) . Although the core metabolic pathways involving glucose have been emphasized as the ...
Biggar Robert J - - 2013
ABSTRACT: INTRODUCTION: Digoxin use is associated with increased incidence of breast and uterus cancers. We postulated that digoxin use might affect tumor characteristics and increase relapse risk in women with breast cancer. METHODS: Incident breast cancer cases in Danish women (N= 49,312; 1995-2008) were identified. Analyses were conducted in women ...
Cusick Kathleen D - - 2013
Paralytic shellfish toxins are secondary metabolites produced by several species of dinoflagellates and cyanobacteria. Known targets of these toxins, which typically occur at detrimental concentrations during harmful algal blooms, include voltage-gated ion channels in humans and mammals. However, the effects of the toxins on the co-occurring phytoplankton community remain unknown. ...
Spataro Pietro - - 2013
The analysis of the interaction between repetition priming and age of acquisition may be used to shed further light on the question of which stages of elaboration are affected by this psycholinguistic variable. In the present study we applied this method in the context of two versions of a lexical ...
Kodama Shuji - - 2013
The content of α-hydroxy acids and their enantiomers can be used to distinguish authentic and adulterated fruit juices. Here, we investigated the use of ligand exchange capillary electrophoresis (CE) with two kinds of central metal ion in a background electrolyte for the simultaneous determination of enantiomers of DL-malic, DL-tartaric and ...
Bashey Asad - - 2013
PURPOSET-cell-replete grafts from haploidentical donors using post-transplantation cyclophosphamide may represent a solution for patients who require allogeneic hematopoietic cell transplantation (alloHCT) but lack a conventional donor. We compared outcomes of alloHCT using haploidentical donors with those of transplantation using conventional HLA-matched sibling donors (MRDs) and HLA-matched unrelated donors (MUDs). PATIENTS ...
Bergman Alicia A - - 2013
Variations in patient-centered care (PCC) models and approaches contribute to ambiguity in how PCC is understood and defined, especially with regard to meeting the needs of diverse patient populations. One of the biggest challenges of putting PCC into practice is knowing what elements are the most important to patients. This ...
Vayá Amparo - - 2013
The association between hyperhomocysteinemia (HHcy) and Raynaud's phenomenon (RP) remains a matter of debate. In 18 primary RP, 23 secondary RP and 41 controls, we investigated homocysteine (Hcy) levels along with biochemical and inflammatory parameters. The Hcy levels in both primary and secondary RP were elevated when compared with controls ...
Samei E - - 2013
A method was developed to assess the multi-directional modulation transfer function (MTF) of breast tomosynthesis imaging systems using a sphere phantom. The method was initially developed based on a simulation dataset. Projections were simulated for a uniform voxelized breast phantom with sphere inserts using a fluence modeled from a 28 ...
Chung Eric - - 2013
INTRODUCTION: Penile traction therapy (PTT) has gained considerable popularity as a noninvasive treatment option in Peyronie's disease (PD) to improve penile curvature and length. However the exact mechanism of action of PTT is unknown and as yet unproven. AIM: Using a cyclic strain culture system, we investigate the cellular changes ...
Birk Julia - - 2013
The reducing power of glutathione, expressed by its reduction potential E(GSH), is an accepted measure for redox conditions in a given cell compartment. In the endoplasmic reticulum (ER), E(GSH) is less reducing than elsewhere in the cell. However, attempts to determine E(GSH)(ER) have been inconsistent and based on ineligible assumptions. ...
Ben-Efraim Yair J YJ The National Centre for Suicide Research and Prevention of Mental Ill-Health (NASP), Karolinska Institute (KI), Stockholm, - - 2013
The cortisol response to psychosocial stress may become dysregulated in stress-related disorders. It is potentiated by pituitary secretion of adrenocorticotropic hormone (ACTH), which is, in part, regulated by arginine vasopressin receptor-1B (AVPR1B). AVPR1B variants were previously reported to associate with mood and anxiety disorders. This study aims, for the first ...
Neves Livia - - 2013
Abstract Parasite community was studied in 202 specimens of Astronotus ocellatus, collected from a freshwater lake in the state of Amapá, northern Brazil. Relationships between some host attributes (i.e. ontogeny, sex and body size) and parasite infections were analyzed, but the main focus was the seasonal variation in the parasite ...
Ma Jun - - 2013
Nitrobenzene (NB) is an important organic compound intermediate that is widely used in industry. In this present study, to evaluate the phytotoxicity and genotoxicity of NB on plants, Vicia faba was exposed to increasing concentrations of NB (5, 10, 25, 50, and 100 mg L(-1) ). The data revealed that ...
Zong Kyukwan - - 2013
4,4'-Bis-(4-pentenyl)-dithieno[3,2-b:2',3'-d]germole was synthesized as a functional building block for the efficient preparation of dithienogermole (DTG) derivatives with varying alkyl chain lengths and pendant functionalities in excellent yields. These derivatives were efficiently isolated via olefin cross-metathesis followed by hydrogenation.
Reynolds Greg D - - 2013
Two experiments assessing event-related potentials in 5-month-old infants were conducted to examine neural correlates of attentional salience and efficiency of processing of a visual event (woman speaking) paired with redundant (synchronous) speech, nonredundant (asynchronous) speech, or no speech. In Experiment 1, the Nc component associated with attentional salience was greater ...
Sun Daochun - - 2013
Malignant peripheral nerve sheath tumor (MPNST) is a type of soft tissue sarcoma that occurs in carriers of germline mutations in Nf1 gene as well as sporadically. Neurofibromin, encoded by the Nf1 gene, functions as a GTPase activating protein (GAP) whose mutation leads to activation of wt-RAS and mitogen-activated protein ...
Mancino Alessandra A Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille Université, UM2, Marseille, - - 2013
Dendritic cells (DC) are required for priming antigen-specific T cells and acquired immunity to many important human pathogens, including Mycobacteriuim tuberculosis (TB) and influenza. However, inappropriate priming of auto-reactive T cells is linked with autoimmune disease. Understanding the molecular mechanisms that regulate the priming and activation of naïve T cells ...
Drosch T - - 2013
History and admission findings: A 77-year-old man suffered from recurrent peripheral cerebral embolisms five months after aortic valve replacement with a bioprosthesis (SJM Epic 25 mm).Investigations: MRT scanning of the brain revealed multiple ischemic areas in different vascular territories. Clinical signs of infective endocarditis were missing and markers of infection ...
Narver Heather Lyons - - 2013
Melanoma is a devastating form of skin cancer in humans that is rising in incidence. Animal models of melanoma continue to be instrumental for understanding the disease and for developing and testing therapies. A novel line of melanoma-bearing mice developed at the National Institute of Neurological Disorders and Stroke is ...
Xie Guoxiang - - 2013
Nutrition research is increasingly concerned with the complex interactions between multicomponent dietary ingredients and the human metabolic regulatory system. The substantiation of nutritional health benefits is challenged by the intrinsic complexity of macro- and micronutrients and individualized human metabolic responses. Metabonomics, uniquely suited to assess metabolic responses to deficiencies or ...
Rishikeshi Supriya N - - 2013
Superparamagnetic ZnFe(2)O(4) nanoparticles with size range of 28-38 nm were synthesized by polyol process based on use of varying chain length glycols as solvent. We have offered, for the first time, the plausible mechanism behind in situ formation of zinc ferric oxalate hydroxide hydrate [Fe(2)Zn(C(2)O(4))(2)(OH)(3)](+)·4H(2)O complex from diethylene and polyethylene ...
de Toledo Juliano S - - 2013
The leishmaniasis is a spectral disease caused by the protozoan Leishmania spp, which threatens millions of people worldwide. Current treatments exhibit high toxicity and there is no vaccine available. The need for new lead compounds with leishmanicidal activity is urgent. Considering that many lead leishmanicidal compounds contain a quinoidal scaffold ...
Lubcke Nicole L - - 2013
OBJECTIVE:To present a case of nebulized tissue plasminogen activator (t-PA) treatment for symptomatic plastic bronchitis in a pediatric patient years after a Fontan procedure.CASE SUMMARY:A 13-year-old boy with a history of corrected congenital heart disease was admitted to the pediatric intensive care unit after 2 weeks of worsening respiratory distress. ...
Tomasi Giampaolo - - 2013
The κ-opioid receptors (KOR) are involved in mood disorders and addictive conditions. In vivo imaging studies of this receptor in humans have not been reported because of the lack of a selective ligand. We used a recently developed selective KOR agonist tracer, (11)C-GR103545, and performed a study in rhesus monkeys ...
Borovkov Vsevolod I - - 2013
The goal of this work is to reveal the effect that an irreversible spin-selective reaction of a partner of the spin-correlated radical pair (SCRP) with a third paramagnetic particle has on the spin state of the surviving SCRPs in the absence of spin exchange interaction. As studied SCRPs, we used ...
Flanagan Jonathan M JM Texas Children's Hematology Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. - - 2013
Stroke is a devastating complication of sickle cell anemia (SCA), occurring in 11% of patients before age 20 years. Previous studies of sibling pairs have demonstrated a genetic component to the development of cerebrovascular disease in SCA, but few candidate genetic modifiers have been validated as having a substantial effect ...
Carli Vladimir - - 2013
Background: Declared suicidal intent and physical danger are both considered important components in defining suicidal behaviors (SB). Aims: 1) To investigate characteristics of serious suicidal behaviors (SSB), defined by either suicidal intent or lethality; 2) To determine any difference in terms of socio-demographic, clinical and/or service usage variables between SSB ...
Tang Jia - - 2013
Nine new triterpenoid saponins named longicarposides A-I (1-9), together with three known saponins (10-12), were isolated from the stems of Gordonia longicarpa. The structures of the saponins were elucidated by a combination of 1D and 2D NMR techniques, mass spectrometry, and chemical methods. They were characterized to be oleanane-type saponins ...
Makyła Katarzyna - - 2013
Yellow fluorescent protein (YFP) is used as a mechanoresponsive layer at the fiber-resin interface in glass-fiber-reinforced composites. The protein loses its fluorescence when subjected to mechanical stress. Within the material, it reports interfacial shear debonding and barely visible impact damage by a transition from a fluorescent to a non-fluorescent state.
Gunnell John G - - 2013
During the last half of the twentieth century, the concept of system was arguably the most important concept in the theoretical repertoire of the discipline of American political science. Although systems analysis was broadly employed in the behavioral sciences, David Easton's work was particularly influential in the study of politics. ...
Kreizinger Zsuzsa Z Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, - - 2013
Several new taxa belonging to the genus Francisella have been described recently. The present study describes the prevalence of Francisella tularensis and Francisella-like endosymbionts (FLE) in ticks collected from Hungary from 2007 to 2009 and characterizes the genetic variability of FLEs. A total of 5402 Ixodid ticks (Ixodes ricinus, I. ...
Wang Shizhi - - 2013
Genetic variations in miRNAs have been demonstrated to be capable of altering miRNA expression, consequently affecting many cancer-related biological processes. The MIR196A2 rs11614913 (T > C) polymorphism has been reported to be associated with various cancers development and progression. In our study, we aim to explore whether this polymorphism is relevant to ...
Hermans Sabine M - - 2013
BACKGROUND: There is a high incidence of tuberculosis (TB) early after antiretroviral treatment (ART) initiation. This historical cohort study evaluated the association of efavirenz (EFV) compared to nevirapine (NVP) with post-ART TB among patients initiated on first-line ART from 2005 to 2009 in a large, urban HIV clinic in Uganda. ...
Unsinn Andreas - - 2013
A practical zinc insertion starting from cheap commercial zinc powder and TMPCl (1-chloro-2,2,6,6-tetramethylpiperidine) allows a fast and efficient synthesis of the zinc base TMPZnCl·LiCl under mild conditions in high yields. This base is kinetically highly active and was used for the regio- and chemoselective functionalization of dibromodiazines (pyridazines and pyrazines).
Regan R C - - 2013
Second-opinion histopathology is a common practice in human medicine to avoid unnecessary procedures, costs and to optimize therapy. Histopathology review has been recommended in veterinary oncology as well. In this prospective evaluation of 52 tumours over a 1-year period, there was diagnostic agreement between first and second opinions in 52% ...
Turner Travis C TC Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, - - 2013
The regioselective intermolecular coupling reaction of vindoline with a wide range of substrates including β-ketoesters, β-diketones, β-ketoaldehydes, β-ketonitriles, malononitriles, and β-cyanoesters provides an opportunity for the synthesis of vinblastine analogues containing deep-seated changes in the upper velbanamine subunit. The transition-metal-free hypervalent iodine(III)-promoted intermolecular sp(3)/sp(2) coupling, representing a special class of ...
Wei Lianhu - - 2013
In multiple sclerosis (MS), myelin basic protein (MBP), critical for the maintenance of myelin compaction and protecting against degradation, is known to contain concentrations of the noncoded amino acid, "citrulline", in abnormal proportions. Peptidyl arginine deiminase (PAD) catalyzes the post-translational citrullination of proteins via the deimination of Arg residues. In ...
Rostain Anthony - - 2013
Objective: Therapeutic goals for chronic mental disorders like major depressive disorder (MDD) and schizophrenia have evolved in parallel with the growing medical knowledge about the course and treatment of these disorders. Although the knowledge base regarding the clinical course of ADHD, a chronic psychiatric disorder, has evolved beyond symptomatic improvement ...
Hussein Ayad Ahmed - - 2013
BACKGROUND: Patients with thalassemia in developing countries have limited access to safe transfusions, regular medical care and chelation therapy. Although allogeneic hematopoietic stem cell transplantation (HSCT) can offer a curative approach, there are limited data on the use of this procedure in developing countries. PROCEDURE: Forty-four patients underwent a risk ...
Caparelli Michael L ML Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY, - - 2013
Chk1 is the effector kinase of the G 2 DNA damage checkpoint. Chk1 homologs possess a highly conserved N-terminal kinase domain and a less conserved C-terminal regulatory domain. In response to DNA damage, Chk1 is recruited to mediator proteins assembled at lesions on replication protein A (RPA)-coated single-stranded DNA (ssDNA). ...
Moheet A - - 2013
PURPOSE: Hypothalamic GABA signaling has been shown to regulate the hormonal response to hypoglycemia in animals. The hypothalamus is a challenging brain region for magnetic resonance spectroscopy (MRS) due to its small size and central location. To investigate the feasibility of measuring GABA in the hypothalamus in humans, ultra-high field ...
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