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Fu Guodong - - 2013
Preeclampsia is a major disorder of pregnancy and a leading cause of maternal and perinatal morbidity and mortality. MicroRNAs are small noncoding RNAs that regulate gene expression posttranscriptionally. In this study, we examined the expression of miR-376c and found that miR-376c levels were downregulated in both placental and plasma samples ...
Wang Suping - - 2013
Acute carbon monoxide poisoning (ACMP) leads to significant toxicity of the central nervous system and heart, and even death, following it, some patients suffered delayed encephalopathy. Until now, no theory had explained it exactly. It was reported that neovascularization was found in acute ischemic brains and also that angiopoietins (Ang) ...
Makouloutou Patrice - - 2013
Abstract Whole-length esophagi of 111 Murrah cross water buffaloes (Bubalus bubalis) were collected in the Kathmandu and Chitwan districts of Nepal during the period December 2009 to February 2010. Gullet worms showing a typical epithelium-dwelling character were detected in 13 of 53 (24.5%) buffaloes in Kathmandu and 5 of 58 ...
Zamora Paul O - - 2013
B2A is a synthetic peptide that augments osteodifferentiation and improves bony fusion when delivered on ceramic granules during arthrodesis surgery. Nonclinical safety assessments, including genotoxicity, supported the use of B2A-coated granules as a combination medical device in pilot clinical studies. As a prelude to pivotal clinical studies, an assessment of ...
Tao Yimin - - 2013
Alzheimer's disease is a worldwide metabolic disease and an economically costly diseases to society, so more medicines need to be developed to treat this disease. Huperzine A, a novel lycopodium alkaloid isolated from tranditional Chinese medicine Huperzia serrata (Qian Ceng Ta), has been shown to possess multiple neuroprotective effects for ...
Wendling Laura A - - 2013
Thorough examination of the physico-chemical characteristics of a Ti processing residue was undertaken including mineralogical, geochemical, and radiochemical characterisation, and an investigation of the environmental toxicity of softwater leachate generated from the residue. Concentrations of most metals measured in the leachate were low; thus, the residue is unlikely to leach ...
Mitsuhashi Wataru - - 2013
BACKGROUND: Entomopoxviruses (EVs) form two types of inclusion bodies: spheroids, which contain virions, and spindles, which do not. We tested whether the spindles from a coleopteran EV, Anomala cuprea EV (ACEV), enhanced the insecticidal activity of a commercial Bacillus thuringiensis (Bt) formulation and the susceptibility of scarabaeid pest species in ...
Kato Tamaki - - 2013
Craniometaphyseal dysplasia (CMD; OMIM#123000) is a rare genetic disorder characterized by hyperostosis of the craniofacial bones and metaphyseal flaring of the long bones. Patients with CMD often suffer from neurological symptoms due to obstruction of the cranial foramina (1). CMD is inherited as an autosomal dominant trait, or occurs sporadically ...
Vidyalakshmi Subramanian - - 2013
Abstract Generation of productive transcripts of protein coding genes in eukaryotes is a complex, multistep process centrally controlled by the RNA polymerase II (Pol II) complex. The carboxy terminal domain (CTD) of the largest subunit of the enzyme is designed to be modified by differential phosphorylation, and plays a key ...
Yuan Ahu - - 2013
Doxorubicin is an antitumor drug commonly used against a wide spectrum of tumors. However, the clinical application of DOX is restricted by its cardiotoxicity. To reduce the cardiotoxicity, we develop an albumin-based nanocarrier via a new molecular switch method for DOX delivery. Spherically shaped DOX-loaded HSA nanoparticles (NPs-DOX) are prepared ...
Lewandowski Wiktor - - 2013
Hybrid structures made of metal nanoparticles with liquid crystalline coating attract considerable attention due to their conspicuous self-assembly and potential synergistic properties. Here we report on a new structural parameter that can be used to control the formation of hybrid gold nanoparticles superlattice. Series of Au nanoclusters covered with mixed ...
Kaufman Sydney H - - 2013
In the present study, we investigate the spectroscopy and photochemical behavior of chromate ester cluster ions in vacuo in the visible and near UV. Chromate ester cluster ions Nan[CrO3(OCH3)]n+1- (n = 1, 2) are generated by electrospray ionization of sodium dichromate in water and methanol. Upon irradiation with photon energies ...
Wang Shanshan - - 2013
Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase (HMT) that contributes to the epigenetic silencing of target genes that regulates cancer cells growth and survival. EZH2 is overexpressed in hepatocellular carcinoma (HCC) with clinical significance that remains obscure. Sorafenib, a multikinase inhibitor, has been used as a ...
Heinen Jennifer - - 2013
The synthesis of a series of co-oligomer amphiphiles by RAFT and their self-assembly behaviour in water is described. These novel amphiphiles, comprised of styrene, butyl acrylate and alkyl hydrophobes together with ionizable acrylic acid and nonionic hydroxyethylacrylate hydrophilic moieties and with total degrees of polymerization from 5 to 17, are ...
Day K M - - 2013
AIMS: To evaluate two chromogenic media, Brilliance CRE and chromID CARBA, with stool samples referred to the Public Health Laboratories Division of the National Institute of Health in Islamabad, and assess the prevalence of carbapenemase-producing Enterobacteriaceae (CPE) in this population. METHODS AND RESULTS: One hundred and fifty two stool samples ...
Head Stuart J - - 2013
OBJECTIVES: Risk prediction in adult patients undergoing cardiac surgery remains inaccurate and should be further improved. Therefore, we aimed to identify risk factors that are predictive of mortality, stroke, renal failure and/or length of stay after adult cardiac surgery in contemporary practice. METHODS: We searched the Medline database for English-language ...
Bredtmann Timm - - 2013
Pericyclic reactions with energies E well above the potential energy barrier B (case E>B) proceed with quantum nuclear flux densities 〈j〉 which are essentially proportional to the nuclear densities ρ in the femtosecond time domain. This corresponds to the definition of classical (cl) mechanics, j(cl) =υ(cl) ρ(cl) , with almost ...
Nambiar Prashant R - - 2013
A factor limiting widespread use of the transgenic rasH2 mouse model for carcinogenicity testing of pharmaceuticals is the paucity of published data on actual drug candidates in rasH2 mice. This report addresses this gap by highlighting rasH2 mouse study data for 10 pharmaceutical candidates. These results were compared with findings ...
Wang Hao - - 2013
Here we present results that investigate the origins of signals observed in tip-enhanced Raman (TERS) measurements of functionalized nanoparticles. Surface enhanced Raman scattering (SERS) is known to give the largest enhancements in gap junctions. Similarly, gap-mode TERS also produces significant enhancements. The methodology developed here provides gap-mode like enhancements in ...
Granö Niklas - - 2013
Background: Little is known about how symptoms are changed in adolescents who receive treatment in an early detection and intervention service. Aims: The aims of the present research were to study change in depression, anxiety and hopelessness symptoms in a sample of help-seeking adolescents who participated in a community- and ...
Seth Akhil K - - 2013
Bacterial biofilms, a critical chronic wound mediator, remain difficult to treat. Energy-based devices may potentially improve healing, but with no evidence of efficacy against biofilms. This study evaluates noncontact, low-frequency ultrasound (NLFU) in the treatment of biofilm-infected wounds. Six-millimeter dermal punch wounds in rabbit ears were inoculated with 10(7) colony-forming ...
Sepsas Evangelos - - 2013
OBJECTIVESPatients undergoing thoracotomy were studied to compare the effects of cryoanalgesia, combined with intravenous patient-controlled analgesia (IVPCA), against IVPCA alone during the four days following surgery.METHODSFifty patients were randomized into two groups: an IVPCA group (n = 25) and an IVPCA-cryo group (n = 25). Subjective pain intensity was assessed ...
Sänze Sandra - - 2013
Gas sensors at work: The mode of operation of metal-oxide gas sensors can be studied by simultaneous measurement of the sensor response, adsorbates, changes in the metal-oxide material, and gas-phase composition by operando Raman-FTIR spectroscopy. Depending on the gas environment and temperature, for EtOH sensing by In(2) O(3) , a ...
Sundstrøm Terje - - 2013
Biological and therapeutic advances in melanoma brain metastasis are hampered by the paucity of reproducible and predictive animal models. In this work, we have developed a robust model of brain metastasis that empowers quantitative tracking of cellular dissemination and tumor progression. Human melanoma cells labeled with superparamagnetic iron oxide nanoparticles ...
de Zeeuw Sandra - - 2013
AIM: To non-invasively study if compensation and decompensation occurs in the urinary bladder of healthy male volunteers in response to benign prostatic enlargement (BPE) using the condom catheter method. METHODS: Between 2001 and 2010, 1,020 healthy male volunteers were included in a longitudinal study based on three non-invasive urodynamic examinations ...
Calabrese Edward J - - 2013
This paper provides a detailed historical assessment of the origin and developmental progress of the concept of wound healing and its attempted acceleration from its start in the beginning of the 20th century to approximately 1960. Emphasis is placed on the development of cell culture in the assessment of wound ...
Gogoi Nayanmoni - - 2013
Heptacoordinated nickel(II) complexes characterized by substantial Ising-type single-ion anisotropy have been involved in the construction of two pentanuclear [Ni(3)W(2)] compounds by association with [W(CN)(8)](3-). For one of them, slow relaxation of magnetization was observed to occur concomitantly with antiferromagnetic ordering.
Xu Boqun - - 2013
ABSTRACT: BACKGROUND: We found previously that the expression of SET gene was up-regulated in polycystic ovaries. Evidences suggested that SET protein was essential for regulating both the promoter activity of CYP17A1 and the biological activity of P450c17. In this study, we explored whether SET regulated androgen production in preantral follicles. ...
Vastani Nisha - - 2013
OBJECTIVES: The conformational state of voltage-gated sodium channels is an important determinant for the efficacy of both local anesthesia and electrical neuromodulation techniques. This study investigated the role of subthreshold preconditioning ramp currents on axonal nerve excitability parameters in the presence of sodium channel blockers in myelinated A and unmyelinated ...
Mitome Hiroumi - - 2013
Herein, we report the synthesis of a novel heterohexanuclear complex (1) of a heteroaromatic cofactor, pyrroloquinolinequinone (PQQ). The crystal structure of 1 was determined to reveal that two PQQ-bridged Ru(II)Ag(I) units were linked by two [Ag(I)(OTf)(2)](-) units (OTf = CF(3)SO(3)(-)). A solvent-bound Ru(II)Ag(I) heterodinuclear complex (2) was formed from 1 ...
Liu Liang-Yan - - 2013
Two new sesquiterpenoids, tremulenolide D (1) and muurolane-10β,15-diol (2), together with four known sesquiterpenoids, tremulenediol A (3), 2β-hydroxy-α-candinol (4), epicubenol (5), and 3β-hydroxy-δ-candinol (6), were isolated from cultures of the fungus Ceriporia alachuana. The structures of new compounds were determined by extensive spectroscopic analyses. Structurally, compounds 1 and 3 are ...
Baraba Anja - - 2013
Abstract Objective: The aim of the study was to evaluate the microtensile bond strength of a composite resin to dentin modified with three different pulse durations of the Er:YAG laser based on variable square pulse technology and with one self-etch adhesive. Materials and methods: The entire occlusal enamel was removed ...
Liskey Carl W - - 2013
The borylation of cyclopropanes catalyzed by the combination of (η6-mes)IrBpin3 or [Ir(COD)OMe]2 and a phenanthroline derivative is reported. The borylation occurs selectively at the methylene C-H bonds of the cyclopropane ring over methine or methyl C-H bonds. High diasteroselectivities were observed from reactions catalyzed by the combination of iridium and ...
Michot Laurent J - - 2013
The coagulation of sodium montmorillonite by inorganic salts (NaNO3, Ca(NO3)2 and La(NO3)3) was studied by combining classical turbidity measurements with Wide-Angle-X-ray Scattering (WAXS), Small-Angle-X-ray Scattering (SAXS) and Transmission X-ray Microscopy (TXM). Using size-selected samples, such a strategy associated with an original quantitative treatment of TXM images, provides a true multi-scale ...
Guo Pengfei - - 2013
Low-threshold nanoscale lasers are attractive for their promising applications in highly integrated photonic devices and systems. Here we report the controllable growth of composition-symmetric CdSxSe1-x nanowires by using a multi-step thermal evaporation route with moving sources. Microstructure analyses reveal the obtained wires are high-quality single crystals with the composition gradually ...
Shigemi Hiroko - - 2013
Clofarabine (CAFdA) is incorporated into leukemic cells by human Equilibrative Nucleoside Transporters (hENT) 1 and 2 and human Concentrative Nucleoside Transporter (hCNT) 3. CAFdA is then phosphorylated to the active metabolite CAFdA triphosphate (CAFdATP) by deoxycytidine kinase (dCK) and deoxyguanosine kinase (dGK). Two novel CAFdA-resistant variants were established and their ...
Bunupuradah Torsak - - 2013
There is no consensus regarding a best dosing regimen of hepatitis B virus vaccine (HBVV) for non-responsive HIV-infected individuals. Double-dose of hepatitis B vaccine (DDHBVV) could enhance immunogenicity to HBVV in non-responsive HIV-infected adults. We assessed the immunogenicity of DDHBVV in HIV-infected adolescents who failed to respond to standard HBVV ...
Wang Xin - - 2013
Abstract During hydrolysis of lignocellulosic biomass, a broad range of inhibitors are generated, which interfere with yeast growth and bioethanol production. In order to improve the strain tolerance to multiple inhibitors-acetic acid, furfural, and phenol (three representative lignocellulose-derived inhibitors) and uncover the underlying tolerant mechanism, an adaptation experiment was performed ...
Lee Jae Young - - 2013
Over the past decade, there has been substantial interest in the role of the integral myelin protein, Nogo-A, from fundamental neurobiological to clinical perspectives. It is now a well-known inhibitor of neurite outgrowth through its cognate receptor, Nogo receptor 1 (NgR1). Nogo-A can only signal through NgR1 upon heteromeric collaboration ...
Matero Sanni - - 2013
The manufacturing of tablets involves many unit operations that possess multivariate and complex characteristics. The interactions between the material characteristics and process related variation are presently not comprehensively analyzed due to univariate detection methods. As a consequence, current best practice to control a typical process is to not allow process-related ...
Tonne Cathryn - - 2013
AimsThe aim of this study was to determine (i) whether long-term exposure to air pollution was associated with all-cause mortality using the Myocardial Ischaemia National Audit Project (MINAP) data for England and Wales, and (ii) the extent to which exposure to air pollution contributed to socioeconomic inequalities in prognosis.Methods and ...
Atay Musa - - 2013
Orbital penetrating injuries may cause significant harm to optic nerves and eyeball as well as to the brain and cerebral vasculature. Defining surrounding neurovascular structures by CT angiography (CTA) is important for surgical removal. We present an uncommon case of a 3-year-old child with a penetrating orbital injury caused by ...
Norais Cédric - - 2013
Pyrococcales are members of the order Thermococcales, a group of hyperthermophilic euryarchaea that are frequently found in deep sea hydrothermal vents. Infectious genetic elements, such as plasmids and viruses, remain a threat even in this remote environment and these microorganisms have developed several ways to fight their genetic invaders. Among ...
Cruz-Silva Rodolfo - - 2013
In this work we carried out chemical oxidation studies of nitrogen-doped multiwalled carbon nanotubes (CNx-MWCNTs) using potassium permanganate in order to obtain nitrogen-doped graphene nanoribbons. Reaction parameters such as: oxidation reaction, reaction time, the oxidizer to nanotube mass ratio, and the temperature were varied and their effect carefully analyzed. The ...
Gewirtz David A - - 2013
Autophagy and senescence share a number of characteristics, which suggests that both responses could serve to collaterally protect the cell from the toxicity of external stress such as radiation and chemotherapy and internal forms of stress such as telomere shortening and oncogene activation. Studies of oncogene activation in normal fibroblasts ...
Khullar Vik - - 2013
AIMS: To discuss the importance of patients' treatment goals and perceived goal attainment to better address expectations in the treatment of lower urinary tract symptoms (LUTS), including overactive bladder (OAB). METHODS: The development of the Self-Assessment Goal Achievement (SAGA) questionnaire was driven by measurement principles from the field of qualitative ...
Su Shan-Shan - - 2013
Our current marine natural product program investigated the second metabolites of an actinomycete Streptomyces cavourensis YY01-17 originating from the Antarctic ecological niche to discover potential antitumor chemical entities. Two new compounds, along with a known compound, were isolated from the ethyl acetate extract of the fermentation broth of the marine-derived ...
Senguttuvan Premkumar - - 2013
We report the direct synthesis of powder Na3Ti2(PO4)3 together with its low potential electrochemical performance and crystal structure elucidation for the reduced and oxidized phases. First principles calculations at the density functional theory level (DFT) has been performed to get further insight on the electrochemistry of Ti(IV)/Ti(III) and Ti(III)/Ti(II) redox ...
Haensig Martin - - 2013
OBJECTIVES: Conventional surgical risk scores are used to identify suitable candidates for transapical aortic valve implantation (TA-AVI) at present. However, these scores do not consider multiple high-risk conditions, including porcelain aorta, mediastinal irradiation or frailty. The aim of this study was to compare the predictive ability of the new EuroSCORE ...
Huang Juzheng - - 2013
Urine is considered an ideal biofluid for clinical investigation because it is obtained non-invasively and relatively large volumes are easily acquired. In this study, selected ion flow tube mass spectrometry (SIFT-MS) has been applied for the quantification of volatile organic compounds (VOCs) in the headspace vapor of urine samples, which ...
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