Search Results
Results 601 - 650 of 3049
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Witt Agnes Hauschultz - - 2013
BACKGROUND AND PURPOSE: Guidelines recommend carotid endarterectomy (CEA) within 2 weeks from an ischemic event. However, previous studies have shown that only a minority of patients undergo CEA within this period. The aim of this study was to examine the effect of a multidisciplinary nationwide initiative aimed at reducing time ...
Spindler Philipp E - - 2013
Distance and spins: A new broadband, frequency-selective inversion pulse has been devised for pulsed electron-electron double resonance (PELDOR) spectroscopy, a unique method used to determine distance distributions between two or more paramagnetic centers 2-10 nm apart. The PELDOR modulation depth can be increased by substituting the rectangular pump pulse by ...
Kuhl Thomas - - 2013
The combination of heparin-induced thrombocytopenia (HIT) II, left ventricular failure with extracorporeal membrane oxygenation (ECMO) therapy, and recurrent left ventricular thrombosis is rare and predicts a poor outcome. In this case, HIT II occurred after an ischemic cardiogenic shock. We initiated ECMO and intra-aortic balloon pump therapy during coronary artery ...
Zou Shien - - 2013
ABSTRACT: BACKGROUND: Several peripheral proteins that might be useful for detecting the presence of ectopic pregnancy (EP) have been evaluated, but none have been proven entirely useful in the clinic. We investigated the presence and the possible changes in circulating molecules that distinguish between normal intrauterine pregnancy (IUP) and tubal ...
Fukuda Thiago Yukio - - 2013
BACKGROUND:Recent studies have shown that an early start of open kinetic chain (OKC) exercises for quadriceps strengthening in a full range of motion (ROM) could increase anterior knee laxity after anterior cruciate ligament (ACL) reconstruction with flexor tendons. However, there are no clinical trials that evaluated outcomes of OKC exercises ...
Liu Rong - - 2013
The development of classification nano-structure-activity Relationships (nano-SARs) of nanoparticle (NP) bioactivity is presented with the aim of demonstrating the integration of multiparametric toxicity/bioactivity assays to arrive at statistically meaningful class definitions (i.e., bioactivity/inactivity endpoints), as well as the implications of nano-SAR applicability domains and decision boundaries. Nano-SARs are constructed based ...
Sjåheim Tone B - - 2013
In order to identify which T-cell subset that in particular were activated in the asthmatic bronchia, we developed a triple colour immunohistofluoresence labelling technique on cryosection to discriminate activated CD4+CD25+ T cells, (effector T cells) from Foxp3+ regulatory T-cells (Treg). Additional coexpression of activation and proliferation markers were also examined ...
Zamora Paul O - - 2013
The biocompatibility/inflammation profile of B2A-coated ceramic granules was evaluated using a panel of standard biocompatibility protocols (International Organization for Standardization-10993) including skin irritation and delayed-type hypersensitivity (Kligman maximization test), as well as acute, subacute, and chronic toxicity. Additionally, the potential of B2A-coated granules to elicit inflammatory reactions was also assessed ...
Li Siying - - 2013
This paper describes how a multistage analysis strategy for a clinical trial can assess a sequence of hypotheses that pertain to successively more stringent criteria for excess risk exclusion or superiority for a primary endpoint with a low event rate. The criteria for assessment can correspond to excess risk of ...
Young Rowan D - - 2013
It's easy to C: The reaction of [Re(CO)(2) (CS)(η-C(5) H(5) )] with [Re(CO)(2) (thf)(η-C(5) H(5) )] affords the disulfur complex [Re(CO)(2) (η(2) -S(2) )(η-C(5) H(5) )] and the remarkably simple μ-carbido complex [(μ-C){Re(CO)(2) (η-C(5) H(5) )}(2) ], which has been structurally characterized and computationally investigated (see picture; black C, white ...
Fillaud Laure - - 2013
Dissymmetric π-conjugated monomers and oligomers incorporating 3,4-ethylenedioxythiophene (EDOT) units and bearing terpyridine end groups were synthesized in good yields through Vilsmeyer-Haak formylation followed by a reaction with 2-acetylpyridine in basic media or, for the longest oligomers, direct C-H bond arylation. They have a low HOMO-LUMO gap and are easily oxidized ...
Kang Seung-Gu - - 2013
Biocompatibility is often regarded as one important aspect of de novo designed nanomaterials for biosafety. However, the toxicological effect, appearing along with its latency, is much more difficult to address by linearly mapping physicochemical properties of related nanomaterials with biological effects such as immune or cellular regulatory responses due to ...
Lee Jea Whan - - 2013
INTRODUCTION.: Orgasmic headache (OH) is a sudden and severe headache that occurs at the time of or shortly after an orgasm. AIM.: We present the case of typical primary headache associated with sexual activity, especially during an orgasmic period. METHODS.: A 34-year-old man complained of sudden and severe headache during ...
Fu Guodong - - 2013
Preeclampsia is a major disorder of pregnancy and a leading cause of maternal and perinatal morbidity and mortality. MicroRNAs are small noncoding RNAs that regulate gene expression posttranscriptionally. In this study, we examined the expression of miR-376c and found that miR-376c levels were downregulated in both placental and plasma samples ...
Wang Suping - - 2013
Acute carbon monoxide poisoning (ACMP) leads to significant toxicity of the central nervous system and heart, and even death, following it, some patients suffered delayed encephalopathy. Until now, no theory had explained it exactly. It was reported that neovascularization was found in acute ischemic brains and also that angiopoietins (Ang) ...
Makouloutou Patrice - - 2013
Abstract Whole-length esophagi of 111 Murrah cross water buffaloes (Bubalus bubalis) were collected in the Kathmandu and Chitwan districts of Nepal during the period December 2009 to February 2010. Gullet worms showing a typical epithelium-dwelling character were detected in 13 of 53 (24.5%) buffaloes in Kathmandu and 5 of 58 ...
Zamora Paul O - - 2013
B2A is a synthetic peptide that augments osteodifferentiation and improves bony fusion when delivered on ceramic granules during arthrodesis surgery. Nonclinical safety assessments, including genotoxicity, supported the use of B2A-coated granules as a combination medical device in pilot clinical studies. As a prelude to pivotal clinical studies, an assessment of ...
Tao Yimin - - 2013
Alzheimer's disease is a worldwide metabolic disease and an economically costly diseases to society, so more medicines need to be developed to treat this disease. Huperzine A, a novel lycopodium alkaloid isolated from tranditional Chinese medicine Huperzia serrata (Qian Ceng Ta), has been shown to possess multiple neuroprotective effects for ...
Wendling Laura A - - 2013
Thorough examination of the physico-chemical characteristics of a Ti processing residue was undertaken including mineralogical, geochemical, and radiochemical characterisation, and an investigation of the environmental toxicity of softwater leachate generated from the residue. Concentrations of most metals measured in the leachate were low; thus, the residue is unlikely to leach ...
Mitsuhashi Wataru - - 2013
BACKGROUND: Entomopoxviruses (EVs) form two types of inclusion bodies: spheroids, which contain virions, and spindles, which do not. We tested whether the spindles from a coleopteran EV, Anomala cuprea EV (ACEV), enhanced the insecticidal activity of a commercial Bacillus thuringiensis (Bt) formulation and the susceptibility of scarabaeid pest species in ...
Kato Tamaki - - 2013
Craniometaphyseal dysplasia (CMD; OMIM#123000) is a rare genetic disorder characterized by hyperostosis of the craniofacial bones and metaphyseal flaring of the long bones. Patients with CMD often suffer from neurological symptoms due to obstruction of the cranial foramina (1). CMD is inherited as an autosomal dominant trait, or occurs sporadically ...
Vidyalakshmi Subramanian - - 2013
Abstract Generation of productive transcripts of protein coding genes in eukaryotes is a complex, multistep process centrally controlled by the RNA polymerase II (Pol II) complex. The carboxy terminal domain (CTD) of the largest subunit of the enzyme is designed to be modified by differential phosphorylation, and plays a key ...
Yuan Ahu - - 2013
Doxorubicin is an antitumor drug commonly used against a wide spectrum of tumors. However, the clinical application of DOX is restricted by its cardiotoxicity. To reduce the cardiotoxicity, we develop an albumin-based nanocarrier via a new molecular switch method for DOX delivery. Spherically shaped DOX-loaded HSA nanoparticles (NPs-DOX) are prepared ...
Lewandowski Wiktor - - 2013
Hybrid structures made of metal nanoparticles with liquid crystalline coating attract considerable attention due to their conspicuous self-assembly and potential synergistic properties. Here we report on a new structural parameter that can be used to control the formation of hybrid gold nanoparticles superlattice. Series of Au nanoclusters covered with mixed ...
Kaufman Sydney H - - 2013
In the present study, we investigate the spectroscopy and photochemical behavior of chromate ester cluster ions in vacuo in the visible and near UV. Chromate ester cluster ions Nan[CrO3(OCH3)]n+1- (n = 1, 2) are generated by electrospray ionization of sodium dichromate in water and methanol. Upon irradiation with photon energies ...
Wang Shanshan - - 2013
Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase (HMT) that contributes to the epigenetic silencing of target genes that regulates cancer cells growth and survival. EZH2 is overexpressed in hepatocellular carcinoma (HCC) with clinical significance that remains obscure. Sorafenib, a multikinase inhibitor, has been used as a ...
Heinen Jennifer - - 2013
The synthesis of a series of co-oligomer amphiphiles by RAFT and their self-assembly behaviour in water is described. These novel amphiphiles, comprised of styrene, butyl acrylate and alkyl hydrophobes together with ionizable acrylic acid and nonionic hydroxyethylacrylate hydrophilic moieties and with total degrees of polymerization from 5 to 17, are ...
Day K M - - 2013
AIMS: To evaluate two chromogenic media, Brilliance CRE and chromID CARBA, with stool samples referred to the Public Health Laboratories Division of the National Institute of Health in Islamabad, and assess the prevalence of carbapenemase-producing Enterobacteriaceae (CPE) in this population. METHODS AND RESULTS: One hundred and fifty two stool samples ...
Head Stuart J - - 2013
OBJECTIVES: Risk prediction in adult patients undergoing cardiac surgery remains inaccurate and should be further improved. Therefore, we aimed to identify risk factors that are predictive of mortality, stroke, renal failure and/or length of stay after adult cardiac surgery in contemporary practice. METHODS: We searched the Medline database for English-language ...
Bredtmann Timm - - 2013
Pericyclic reactions with energies E well above the potential energy barrier B (case E>B) proceed with quantum nuclear flux densities 〈j〉 which are essentially proportional to the nuclear densities ρ in the femtosecond time domain. This corresponds to the definition of classical (cl) mechanics, j(cl) =υ(cl) ρ(cl) , with almost ...
Nambiar Prashant R - - 2013
A factor limiting widespread use of the transgenic rasH2 mouse model for carcinogenicity testing of pharmaceuticals is the paucity of published data on actual drug candidates in rasH2 mice. This report addresses this gap by highlighting rasH2 mouse study data for 10 pharmaceutical candidates. These results were compared with findings ...
Granö Niklas - - 2013
Background: Little is known about how symptoms are changed in adolescents who receive treatment in an early detection and intervention service. Aims: The aims of the present research were to study change in depression, anxiety and hopelessness symptoms in a sample of help-seeking adolescents who participated in a community- and ...
Seth Akhil K - - 2013
Bacterial biofilms, a critical chronic wound mediator, remain difficult to treat. Energy-based devices may potentially improve healing, but with no evidence of efficacy against biofilms. This study evaluates noncontact, low-frequency ultrasound (NLFU) in the treatment of biofilm-infected wounds. Six-millimeter dermal punch wounds in rabbit ears were inoculated with 10(7) colony-forming ...
Sänze Sandra - - 2013
Gas sensors at work: The mode of operation of metal-oxide gas sensors can be studied by simultaneous measurement of the sensor response, adsorbates, changes in the metal-oxide material, and gas-phase composition by operando Raman-FTIR spectroscopy. Depending on the gas environment and temperature, for EtOH sensing by In(2) O(3) , a ...
Sundstrøm Terje - - 2013
Biological and therapeutic advances in melanoma brain metastasis are hampered by the paucity of reproducible and predictive animal models. In this work, we have developed a robust model of brain metastasis that empowers quantitative tracking of cellular dissemination and tumor progression. Human melanoma cells labeled with superparamagnetic iron oxide nanoparticles ...
de Zeeuw Sandra - - 2013
AIM: To non-invasively study if compensation and decompensation occurs in the urinary bladder of healthy male volunteers in response to benign prostatic enlargement (BPE) using the condom catheter method. METHODS: Between 2001 and 2010, 1,020 healthy male volunteers were included in a longitudinal study based on three non-invasive urodynamic examinations ...
Calabrese Edward J - - 2013
This paper provides a detailed historical assessment of the origin and developmental progress of the concept of wound healing and its attempted acceleration from its start in the beginning of the 20th century to approximately 1960. Emphasis is placed on the development of cell culture in the assessment of wound ...
Gogoi Nayanmoni - - 2013
Heptacoordinated nickel(II) complexes characterized by substantial Ising-type single-ion anisotropy have been involved in the construction of two pentanuclear [Ni(3)W(2)] compounds by association with [W(CN)(8)](3-). For one of them, slow relaxation of magnetization was observed to occur concomitantly with antiferromagnetic ordering.
Xu Boqun - - 2013
ABSTRACT: BACKGROUND: We found previously that the expression of SET gene was up-regulated in polycystic ovaries. Evidences suggested that SET protein was essential for regulating both the promoter activity of CYP17A1 and the biological activity of P450c17. In this study, we explored whether SET regulated androgen production in preantral follicles. ...
Vastani Nisha - - 2013
OBJECTIVES: The conformational state of voltage-gated sodium channels is an important determinant for the efficacy of both local anesthesia and electrical neuromodulation techniques. This study investigated the role of subthreshold preconditioning ramp currents on axonal nerve excitability parameters in the presence of sodium channel blockers in myelinated A and unmyelinated ...
Mitome Hiroumi - - 2013
Herein, we report the synthesis of a novel heterohexanuclear complex (1) of a heteroaromatic cofactor, pyrroloquinolinequinone (PQQ). The crystal structure of 1 was determined to reveal that two PQQ-bridged Ru(II)Ag(I) units were linked by two [Ag(I)(OTf)(2)](-) units (OTf = CF(3)SO(3)(-)). A solvent-bound Ru(II)Ag(I) heterodinuclear complex (2) was formed from 1 ...
Liu Liang-Yan - - 2013
Two new sesquiterpenoids, tremulenolide D (1) and muurolane-10β,15-diol (2), together with four known sesquiterpenoids, tremulenediol A (3), 2β-hydroxy-α-candinol (4), epicubenol (5), and 3β-hydroxy-δ-candinol (6), were isolated from cultures of the fungus Ceriporia alachuana. The structures of new compounds were determined by extensive spectroscopic analyses. Structurally, compounds 1 and 3 are ...
Baraba Anja - - 2013
Abstract Objective: The aim of the study was to evaluate the microtensile bond strength of a composite resin to dentin modified with three different pulse durations of the Er:YAG laser based on variable square pulse technology and with one self-etch adhesive. Materials and methods: The entire occlusal enamel was removed ...
Liskey Carl W - - 2013
The borylation of cyclopropanes catalyzed by the combination of (η6-mes)IrBpin3 or [Ir(COD)OMe]2 and a phenanthroline derivative is reported. The borylation occurs selectively at the methylene C-H bonds of the cyclopropane ring over methine or methyl C-H bonds. High diasteroselectivities were observed from reactions catalyzed by the combination of iridium and ...
Michot Laurent J - - 2013
The coagulation of sodium montmorillonite by inorganic salts (NaNO3, Ca(NO3)2 and La(NO3)3) was studied by combining classical turbidity measurements with Wide-Angle-X-ray Scattering (WAXS), Small-Angle-X-ray Scattering (SAXS) and Transmission X-ray Microscopy (TXM). Using size-selected samples, such a strategy associated with an original quantitative treatment of TXM images, provides a true multi-scale ...
Guo Pengfei - - 2013
Low-threshold nanoscale lasers are attractive for their promising applications in highly integrated photonic devices and systems. Here we report the controllable growth of composition-symmetric CdSxSe1-x nanowires by using a multi-step thermal evaporation route with moving sources. Microstructure analyses reveal the obtained wires are high-quality single crystals with the composition gradually ...
Shigemi Hiroko - - 2013
Clofarabine (CAFdA) is incorporated into leukemic cells by human Equilibrative Nucleoside Transporters (hENT) 1 and 2 and human Concentrative Nucleoside Transporter (hCNT) 3. CAFdA is then phosphorylated to the active metabolite CAFdA triphosphate (CAFdATP) by deoxycytidine kinase (dCK) and deoxyguanosine kinase (dGK). Two novel CAFdA-resistant variants were established and their ...
Bunupuradah Torsak - - 2013
There is no consensus regarding a best dosing regimen of hepatitis B virus vaccine (HBVV) for non-responsive HIV-infected individuals. Double-dose of hepatitis B vaccine (DDHBVV) could enhance immunogenicity to HBVV in non-responsive HIV-infected adults. We assessed the immunogenicity of DDHBVV in HIV-infected adolescents who failed to respond to standard HBVV ...
Wang Xin - - 2013
Abstract During hydrolysis of lignocellulosic biomass, a broad range of inhibitors are generated, which interfere with yeast growth and bioethanol production. In order to improve the strain tolerance to multiple inhibitors-acetic acid, furfural, and phenol (three representative lignocellulose-derived inhibitors) and uncover the underlying tolerant mechanism, an adaptation experiment was performed ...
Lee Jae Young - - 2013
Over the past decade, there has been substantial interest in the role of the integral myelin protein, Nogo-A, from fundamental neurobiological to clinical perspectives. It is now a well-known inhibitor of neurite outgrowth through its cognate receptor, Nogo receptor 1 (NgR1). Nogo-A can only signal through NgR1 upon heteromeric collaboration ...
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