Search Results
Results 601 - 650 of 3060
< 8 9 10 11 12 13 14 15 16 17 18 >
Brodner David - - 2013
BACKGROUND: A multicenter prospective study was conducted to assess the safety and sustained effectiveness of a new instrument possessing multifunctionality as an ostium seeker, suction-irrigator, and malleable balloon-dilator indicated for treating multiple sinuses. METHODS: Endoscopic balloon-only and hybrid-balloon procedures involving dilation of the frontal recesses, maxillary ostia, and/or sphenoid sinus ...
Gupta Anil K - - 2013
BACKGROUND:The management of irreparable massive or full-thickness 2-tendon rotator cuff tears in active patients with minimal glenohumeral arthritis remains a difficult challenge for the treating surgeon. Many different treatment options, with varied success, have been proposed. HYPOTHESES:(1) Patients undergoing reconstruction of irreparable massive or full-thickness 2-tendon rotator cuff tears by ...
O'Loughlin Aonghus A Regenerative Medicine Institute, National Centre for Biomedical Engineering and Science, National University of Ireland Galway, Galway, - - 2013
There is a critical clinical need to develop therapies for nonhealing diabetic foot ulcers. Topically applied mesenchymal stromal cells (MSCs) provide a novel treatment to augment diabetic wound healing. A central pathological factor in nonhealing diabetic ulcers is an impaired blood supply. It was hypothesized that topically applied allogeneic MSCs ...
Choi Sojoong - - 2013
Introduction: Syndecans are cell surface adhesion receptors that play important functional roles. Their deregulation has been linked to several pathologies, and their aberrant regulation via diverse mechanisms is critically involved in the pathogenesis of various cancers. Similar to other receptors, syndecan functions are altered by ligand binding, overexpression, and extracellular ...
Ward Pierre - - 2013
AIMS: The aim of this study was to compare the performance of four RT-qPCR assays for the detection of human and bovine group A rotaviruses and to characterize the positive samples by sequence analysis of VP4 and VP7 genes. METHODS AND RESULTS: RNA extracted from eight human rotavirus strains and ...
Snowden Julie S JS Manchester Academic Health Sciences Centre, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK. - - 2013
Repeat expansions in C9orf72 are a major cause of frontotemporal dementia with amyotrophic lateral sclerosis (FTD-ALS). Not all FTD-ALS patients show expansions. The study examined whether there are clinical differences between FTD-ALS patients with and without expansions in C9orf72. We examined case notes from consecutive FTD-ALS patients, screened for C9orf72 ...
Zhou Qiying - - 2013
Glycine decarboxylase complex (GDC) is a multi-protein complex, comprising P-, H-, T- and L-protein subunits, which plays a major role in photorespiration in plants. While structural analysis has demonstrated the H subunit of GDC (GDCH) plays a pivotal role in GDC, research on the role of GDCH in biological processes ...
Salunke P - - 2013
Calcified chronic subdural collection (armoured brain) is a known long-standing complication of shunt overdrainage. We report a young male who became symptomatic eleven years after a shunt surgery. Radiology showed bilateral calcified subdural collections. Drainage of these collections did not help, but shunt revision did. Patients with armoured brain syndrome ...
Helmer Drew A - - 2013
INTRODUCTION: Sexual health is an important aspect of human existence associated with disease and overall health. Despite these associations and the existence of medical treatments to improve sexual function, sexual health is often overlooked in health care. Recent combat veterans may be particularly vulnerable to sexual health issues due to ...
Newcomb Dawn Catherine DC Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. - - 2013
Viral infections are the most frequent cause of asthma exacerbations and are linked to increased airway reactivity (AR) and inflammation. Mice infected with respiratory syncytial virus (RSV) during ovalbumin (OVA)-induced allergic airway inflammation (OVA/RSV) had increased AR compared with OVA or RSV mice alone. Furthermore, interleukin 17A (IL-17A) was only ...
Lapergue Bertrand - - 2013
BACKGROUND AND PURPOSE: We have previously reported that intravenous injection of high-density lipoproteins (HDLs) was neuroprotective in an embolic stroke model. We hypothesized that HDL vasculoprotective actions on the blood-brain barrier (BBB) may decrease hemorrhagic transformation-associated with tissue plasminogen activator (tPA) administration in acute stroke. METHODS: We used tPA alone ...
Aggarwal Rohit R Department of Medicine, Division of Rheumatology, University of Pittsburgh School of Medicine, , Pittsburgh, Pennsylvania, - - 2014
To compare the cumulative survival and event free survival in patients with Jo-1 versus non-Jo-1 anti-tRNA synthetase autoantibodies (anti-synAb). Anti-synAb positive patients initially evaluated from 1985 to 2009 were included regardless of the connective tissue disease (CTD) diagnosis. Clinical data were extracted from a prospectively collected database and chart review. ...
Neale Peta A - - 2013
The acetylcholinesterase (AChE) inhibition assay is frequently applied to detect organophosphates and carbamate pesticides in different water types, including dissolved organic carbon (DOC) rich wastewater and surface water. The aim of the present study was to quantify the effect of co-extracted DOC from different water samples on the commonly used ...
Ma Jinwon - - 2013
The Young's modulus and fracture strength of Si(1-x)Ge(x) nanowires (NWs) as a function of Ge concentration were measured from tensile stress measurements. The Young's modulus of the NWs decreased linearly with increasing Ge content. No evidence was found for a linear relationship between the fracture strength of the NWs and ...
Chukir Tariq - - 2013
The long-chain 18-carbon fatty acids linoleic, oleic, and stearic acids, retronasally in vapor phase, are discriminated from blanks and each other. However, ability to linguistically identify them was unknown. To explore this, a Focus Group and then Check-All-That-Apply measures gave 9 identifiers for the 3 fatty acids plus phenylethyl alcohol ...
Byakwaga H - - 2013
The majority of HIV-infected patients in developing countries commences combination antiretroviral therapy (cART) with advanced disease. We examined predictors of disease progression in patients initiating cART with CD4 count ≤200 cells/mm(3) in the TREAT Asia HIV Observational Database. The main outcome measure was progression to either an AIDS-defining illness or ...
Fanali Salvatore - - 2013
This paper reports the use of novel phenyl-hexyl core-shell particles packed into fused silica capillaries in nano-liquid chromatography. Capillary columns of different internal diameter (id) of 25, 50, 75, 100 and 150 μm were packed employing the slurry packing method. The columns were used for the separation of a model mixture ...
Hapke Marko - - 2013
Chiral possibilities (Cp): In two approaches for introducing chirality into reactions of half-sandwich Rh complexes, dihydroisoquinolones have been synthesized from benzamides and olefins. In one approach C(2) -symmetric Cp ligands were utilized, while in the other an artificial metalloenzyme was employed as the chiral catalyst, leading to high levels of ...
Mesa Ruben A - - 2013
PURPOSETo assess the effects of ruxolitinib on symptom burden and quality of life (QoL) and to evaluate the ability of the modified Myelofibrosis Symptom Assessment Form (MFSAF) v2.0 to measure meaningful changes in myelofibrosis-related symptoms in patients with myelofibrosis.Patients And methodsCOMFORT-I (Controlled Myelofibrosis Study With Oral JAK Inhibitor Treatment-I) is ...
Workalemahu Tsegaselassie T Department of Epidemiology, Harvard School of Public Health, Boston, MA, - - 2013
BACKGROUND The global prevalence of chronic noncommunicable diseases (NCDs) is on the rise, with the majority of the growth occurring among populations in developing countries. Few studies have quantified the health benefits for physical activity among sub-Saharan African adults. We examined associations of physical activity with the prevalence of metabolic ...
Pérez Laura M LM Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, - - 2013
Adipose-derived stem cells (ASCs) are promising candidates for autologous cell-based regeneration therapies by virtue of their multilineage differentiation potential and immunogenicity; however, relatively little is known about their role in adipose tissue physiology and dysfunction. Here we evaluated whether ASCs isolated from nonobese and obese tissue differed in their metabolic ...
Challis Richard - - 2013
Strigolactones (SLs) are carotenoid-derived phytohormones with diverse roles. They are secreted from roots as attractants for arbuscular mycorrhizal fungi and have a wide range of endogenous functions such as regulation of root and shoot system architecture. To date, six genes associated with SL synthesis and signaling have been molecularly identified ...
Duque Juan G - - 2013
While addition of electrolyte to sodium dodecyl sulfate suspensions of single-wall carbon nanotubes has been demonstrated to result in significant brightening of the nanotube photoluminescence (PL), the brightening mechanism has remained unre-solved. Here, we probe this mechanism using time-resolved PL decay measurements. We find PL decay times increase by a ...
Beilmann M - - 2013
Using drop calorimetry, we measured enthalpy increments of the LiF-KF, LiF-RbF, and LiF-CsF binary systems at temperatures above the melting point. Ten samples with different compositions (four compositions for LiF-KF, one composition for LiF-RbF, and five compositions for LiF-CsF) were prepared and measured between 884 K and 1382 K. To ...
Nasser Arafat - - 2013
ABSTRACT: BACKGROUND: GTP cyclohydrolase 1 (GTP-CH1), the rate-limiting enzyme in the synthesis of tetrahydrobiopterin (BH4), encoded by the GCH1 gene, has been implicated in the development and maintenance of inflammatory pain in rats. In humans, homozygous carriers of a "pain-protective" (PP) haplotype of the GCH1 gene have been identified exhibiting ...
Gelez Hélène - - 2013
INTRODUCTION.: Flibanserin is a mixed 5-HT1A agonist/5-HT2A antagonist that has been developed for the treatment of hypoactive sexual desire disorder in women. AIM.: To assess the acute and chronic dose-response effects of flibanserin on measures of sexual desire and copulation in ovariectomized rats primed with estradiol benzoate (EB) alone or ...
Li Changyou C Department of Medicine, University of Pittsburgh and the University of Pittsburgh Cancer Institute, Pittsburgh, PA, - - 2013
Human papilloma virus (HPV) infection represents an emerging risk factor in head and neck squamous cell carcinoma (HNSCC). In contrast to HPV-negative HNSCC, most cases of HPV-positive HNSCC encode wild-type p53, although the p53 protein in these cells is rapidly degraded via HPV E6-mediated ubiquitination and subsequent proteasomal degradation. This ...
Brown Nicola - - 2013
The aim of this study was to investigate asthma management self-efficacy in parents of primary school-age children with asthma and to explore possible associations between parent asthma management self-efficacy, parent and child characteristics, asthma task difficulty and asthma management responsibility. A cross-sectional descriptive survey of 113 parents was conducted to ...
Kaimal Rajani R Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, - - 2013
Most patients with ovarian cancer are diagnosed late in progression and often experience tumor recurrence and relapses due to drug resistance. Surface expression of matrix metalloprotease (MMP)-14 on ovarian cancer cells stimulates a tumor-stromal signaling pathway that promotes angiogenesis and tumor growth. In a cohort of 92 patients, we found ...
Chen Shu-Hua - - 2013
Metallation and demetallation of human metallothionein-2A (MT) with Cd2+ is investigated by using chemical labeling and "bottom-up" and "top-down" proteomics approaches. Both metallation and demetallation of MT-2A by Cd2+ are shown to be domain specific and occur as two distinct processes. Metallation involves sequential addition of Cd2+ to the α-domain ...
Bielmyer Gretchen K - - 2013
Nickel (Ni) is a common pollutant found in aquatic environments, and may be harmful at elevated concentrations. Increasing salinity has been shown to decrease the bioavailability and toxicity of other metals to aquatic organisms. In this study, acute Ni toxicity experiments (96-h) were conducted at various salinities (0-36 ppt) in ...
Kang Edward - - 2013
The creation and characterization of large-area ultrathin highly pliable free-standing PDMS membranes and their application to the study of cellular epithelia is described. The ultra-thin membranes permitted the straight forward calculation of cell monolayer moduli, derived from measured stress-strain curves. These measurements allowed the unprecedented detection of cellular-level injury in ...
Rout Raj - - 2013
Within antero-medial gonarthrosis (AMG) of the knee, there is a spectrum of damage seen in the functionally intact anterior cruciate ligament (ACL). Our aim was to correlate the degree of ACL damage to the geographical extent and degree of cartilage loss on the tibial plateau. Ninety tibial plateaus resected during ...
Singh Smriti - - 2013
An efficient and simple synthesis approach to form stable (68) Ga-labeled nanogels is reported and their fundamental properties investigated. Nanogels are obtained by self-assembly of amphiphilic statistical prepolymers derivatised with chelating groups for radiometals. The resulting nanogels exhibit a well-defined spherical shape with a diameter of 290 ± 50 nm. ...
Sylow Lykke L Molecular Physiology Group, Department of Nutrition, Exercise, and Sports, August Krogh Centre, University of Copenhagen, Copenhagen, - - 2013
The actin cytoskeleton-regulating GTPase Rac1 is required for insulin-stimulated GLUT4 translocation in cultured muscle cells. However, involvement of Rac1 and its downstream signaling in glucose transport in insulin-sensitive and insulin-resistant mature skeletal muscle has not previously been investigated. We hypothesized that Rac1 and its downstream target, p21-activated kinase (PAK), are ...
Franzese Ornella - - 2013
It is well known that ionizing radiations induce a marked downregulation of antigen-dependent and natural immunity for a prolonged period of time. This is due, at least in part, to radiation-induced apoptosis of different lymphocyte subpopulations, including natural killer (NK) cells. Aim of this study was to investigate the capability ...
van Veghel Daisy D Laboratory for Radiopharmacy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Campus Gasthuisberg O&N2, Herestraat 49 box 821, 3000 Leuven, - - 2013
The transient receptor potential vanilloid subfamily member 1 (TRPV1) cation channel is known to be involved in pain nociception and neurogenic inflammation, and accumulating evidence suggests that it plays an important role in several central nervous system (CNS)-related disorders. TRPV1-specific positron emission tomography (PET) radioligands can serve as powerful tools ...
Smid Wineke J - - 2013
The Risk Need Responsivity (RNR) principles (Andrews & Bonta, 2010) dictate that higher risk sex offenders should receive more intensive treatment. The present study investigates how clinically based treatment assignment relates to risk level in a sex offender sample from The Netherlands. Correlational analyses served to identify sources of mismatches: ...
Liu Qian-Feng - - 2013
Two new piperidine alkaloids, streptazones E (1) and F (2), were isolated from Streptomyces sp. NEAU-Z4. Their structures were elucidated on the basis of MS and NMR analysis.
Apa Hur┼čit - - 2013
Abstract Brucella infections have a wide spectrum of symptoms especially in children, making the diagnosis a complicated process. The gold standard for the final diagnosis for brucellosis is to identify the Brucella spp. isolated from blood or bone marrow cultures. The main purpose of this work was to evaluate the ...
Kahramaner Zelal - - 2013
A case of neonatal cholestasis associated with Trisomy 18 (Edward's syndrome) is presented. A 3-day-old boy was referred to our clinic due to respiratory distress, elevated serum direct bilirubin levels, a systolic heart murmur, growth restriction and micrognathia. Liver biopsy and chromosomal analysis revealed paucity of intrahepatic bile ducts and ...
Chen Hao - - 2013
Radiation leads to a rapid burst of reactive oxygen species (ROS), which is considered to be one of the major causes of radiation-induced injury. ROS have previously been shown to induce changes in cytosolic Ca(2+) ([Ca(2+)](i)) including [Ca(2+)](i) oscillation. However, the role of radiation in [Ca(2+)](i) oscillation is poorly understood. ...
Lee Bora - - 2013
A specialized Ca(2+) transient at fertilization represents the universal driver for the egg-to-embryo transition. Ca(2+) signaling remodels during oocyte maturation to endow the egg with the capacity to produce the specialized Ca(2+) transient at fertilization, which takes the form of a single (e.g. Xenopus) or multiple (e.g. mouse) Ca(2+) spikes ...
Ebben Remco Ha - - 2013
ABSTRACT: A gap between guidelines or protocols and clinical practice often exists, which may result in patients not receiving appropriate care. Therefore, the objectives of this systematic review were (1) to give an overview of professionals' adherence to (inter)national guidelines and protocols in the emergency medical dispatch, prehospital and emergency ...
Lin Yan-Wei - - 2013
The polycomb group protein enhancer of zeste homolog 2 (EZH2), which has histone methyltransferase (HMT) activity, is overexpressed in malignant tumors. However, the role of EZH2 in colorectal cancer (CRC) invasion is little known. Here we investigated the clinical significance, biological effects and mechanisms of EZH2 signaling. Knockdown of EZH2 ...
Jones Vincent P - - 2013
BACKGROUND: Codling moth, Cydia pomonella (L.) (Lepidoptera: Tortricidae), is a major pest of apple, pear, and walnut production in North America. Management programs are based on preventing larval entry into the fruit or nut and are typically timed by heat-driven models that are synchronized to field populations by first capture ...
Sanders Caroline - - 2013
Irrigation as a bowel management approach has been reportedly used with children for more than 20 years. Parents managing their child's chronic bowel problem have previously been shown to have increased emotional stress. The aim of this study was to explore professionals' (n = 24) understanding and parents' (n = ...
Bonella F - - 2013
Background and objective: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with an estimated median survival of only 3 years after diagnosis. Pirfenidone is the only medication approved in the European Union for the treatment of adults with mild to moderate lung fibrosis. We analyzed data on ...
Tourville Timothy W - - 2013
BACKGROUND:Those who suffer anterior cruciate ligament (ACL) disruptions are at increased risk of experiencing posttraumatic osteoarthritis (OA); however, by the time they become symptomatic, irreversible damage has likely occurred. Little is known regarding the physiological changes in articular cartilage that occur after an ACL injury and the onset of OA. ...
Fuchs Sebastian W - - 2013
Overlooked but widespread! A new class of ketosynthases (DarB) involved in the biosynthesis of 1,3-cyclohexanediones and dialkylresorcinols has been identified and characterized in detail. The presence of homologues in 89 different bacteria, including several pathogens, reveals that DarB as well as the corresponding natural products might be widespread, thus presenting ...
< 8 9 10 11 12 13 14 15 16 17 18 >