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Results 501 - 550 of 3049
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Samaranayake N R - - 2013
Background The primary goal of reducing medication errors is to eliminate those that reach the patient. Objective We aimed to study the pattern of interceptions to tackle medication errors along the medication use processes. Setting Tertiary care hospital in Hong Kong. Method The 'Swiss Cheese Model' was used to explain ...
Dhital Raghu Nath - - 2013
The strong inhibitor effect of aryl iodides on the quasi-homogenous gold-catalyzed oxidation reaction was described. Aryl iodides were adsorbed on the exposed surface of Au clusters, which affected the accessibility of the nanoclusters to the reacting species and acted as strong inhibitors in catalysis.
Chun Chan Lan - - 2013
Avian botulism, a paralytic disease of birds, often occurs on a yearly cycle and is increasingly becoming more common in the Great Lakes. Outbreaks are caused by bird ingestion of neurotoxins produced by Clostridium botulinum, a spore-forming, gram-positive, anaerobe. The nuisance, macrophytic, green alga Cladophora (Chlorophyta; mostly Cladophora glomerata L.) ...
Lin Yen-Ko - - 2013
ABSTRACT: BACKGROUND: To evaluate the effectiveness of a multifaceted intervention in improving emergency department (ED) patient privacy and satisfaction in the crowded ED setting. METHODS: A pre- and post-intervention study was conducted. A multifaceted intervention was implemented in a university-affiliated hospital ED. The intervention developed strategies to improve ED patient ...
Gaylord Monica L - - 2013
To test the hypothesis that drought predisposes trees to insect attacks, we quantified the effects of water availability on insect attacks, tree resistance mechanisms, and mortality of mature piñon pine (Pinus edulis) and one-seed juniper (Juniperus monosperma) using an experimental drought study in New Mexico, USA. The study had four ...
Corazza Ornella - - 2013
AIMS: To review the recreational use of ketamine ("Special K"; KET) and explore the recent diffusion of its new derivative methoxetamine ("Special M"; MXE). METHODS: The literature search on the nonclinical/recreational use of KET and MXE was carried out in a range of medical databases. Considering the limitations of peer-reviewed ...
Leikin J B - - 2013
Context. With regard to biological effects, the increasing number of early failure of metal-on-metal (MoM) hip arthroplasties and possible parenteral exposure to orthopedic metal alloys have caused concern for patients and providers alike. Objective. We sought to characterize our outpatient clinical experience of patients with MoM and other forms of ...
Munneke Moniek A M - - 2013
Introduction: Excitotoxicity plays an important role in the pathogenesis of the preferential motor neuron death observed in ALS. Continuous Theta Burst Stimulation (cTBS) by transcranial magnetic stimulation has an inhibitory effect on corticospinal excitability (CSE). We characterized the neurophysiological changes induced by cTBS in ALS. Methods: The patients received 5 ...
Maitre Julien - - 2013
The purpose of the study was to compare the effects of sensory manipulations on postural control for subjects of different ages. A young group of subjects (n = 17; 20.0 ± 1.3 years) and an old group of subjects (n = 17; 74.7 ± 6.3 years) were compared in 14 postural conditions [2 reference conditions and 12 sensory manipulation conditions: ...
Lee Seon-Yeong - - 2013
ABSTRACT: INTRODUCTION: Fibroblast-like synoviocytes (FLSs) are a major cell population of the pannus that invades adjacent cartilage and bone in rheumatoid arthritis (RA). The study was undertaken to determine the effect of interleukin-17 (IL-17) on the survival and/or proliferation of FLSs from RA patients and to investigate whether signal tranducer ...
Jørgensen C C - - 2013
Smoking and alcohol use impair post-operative outcomes. However, no studies include fast-track surgery, which is a multimodal-enhanced recovery programme demonstrated to improve outcome. We hypothesised that outcome is similar in smokers and alcohol users as in non-users after fast-track hip and knee arthroplasty. Prospective questionnaires on co-morbidity and smoking/alcohol use ...
Fushida S - - 2013
We designed a phase I/II trial of intraperitoneal (IP) docetaxel plus S-1 to determine the maximum tolerated dose (MTD) and recommended dose (RD) and to evaluate its efficacy and safety in gastric cancer patients with peritoneal carcinomatosis (PC). Patients with PC confirmed by laparoscopy or laparotomy received IP docetaxel on ...
Katanuma Akio - - 2013
BACKGROUND: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) provides high diagnostic accuracy with a low incidence of procedural complications. However, it occasionally causes serious complications, and factors that increase the susceptibility to such adverse events remain unknown. AIMS: We aimed to examine post-procedural events and determine risk factors associated with EUS-FNA ...
Sato Yukie - - 2013
Severe intraspecific competition for mates selects for aggressive individuals but may also lead to the evolution of alternative phenotypes that do not act aggressively, yet manage to acquire matings. The two-spotted spider mite, Tetranychus urticae, shows male mate-guarding behaviour and male-male combat for available females. This may provide opportunity for ...
Pillay Janesh - - 2013
Neutrophils are essential effector cells in the host defense against invading pathogens. Recently, novel neutrophil functions have emerged in addition to their classical anti-microbial role. One of these functions is the suppression of T cell responses. In this respect, neutrophils share similarities with granulocytic myeloid-derived suppressor cells (G-MDSCs). In this ...
Kuri Thomas - - 2013
Secondary infections with Streptococcus pneumoniae (SP) are frequently observed following influenza A virus (IAV) infection and have a substantial impact on global health. Despite this, the basis for the disease progression is incompletely understood. To investigate the effect of co-infection on human monocyte-derived dendritic cells (MDDCs) we analyzed the expression ...
Gosling Paul - - 2013
High soil phosphorus (P) concentration is frequently shown to reduce root colonization by arbuscular mycorrhizal (AM) fungi, but the influence of P on the diversity of colonizing AM fungi is uncertain. We used terminal restriction fragment length polymorphism (T-RFLP) of 18S rDNA and cloning to assess diversity of AM fungi ...
Han Jia J Shanghai University of Sport, 650 Qingyuanhuan Road, Yangpu District, Shanghai 200438, China. - - 2013
Superiority of the left upper limb in proprioception tasks performed by right-handed individuals has been attributed to better utilization of proprioceptive information by a non-preferred arm/hemisphere system. However, it is undetermined whether this holds for multiple upper and lower limb joints. Accordingly, the present study tested active movement proprioception at ...
Vierck Charles J CJ Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610-0244, USA. - - 2013
Ramp-and-hold heat stimulation with a Peltier thermode is a standard procedure for quantitative sensory testing of human pain sensitivity. Because myelinated and unmyelinated nociceptive afferents respond preferentially to changing and steady temperatures, respectively, ramp-and-hold heat stimulation could assess processing of input from A-delta nociceptors early and C nociceptors late during ...
De Storme Nico N Department of Plant Production, Faculty of Bioscience Engineering, University of Ghent, Coupure Links 653, B-9000, Gent, - - 2013
In the plant kingdom, events of whole genome duplication or polyploidization are generally believed to occur via alterations of the sexual reproduction process. Thereby, diploid pollen and eggs are formed that contain the somatic number of chromosomes rather than the gametophytic number. By participating in fertilization, these so-called 2n gametes ...
Kim Mihwa - - 2013
The volatile anesthetic isoflurane protects against renal ischemia and reperfusion injury by releasing renal tubular TGF-β1. As adenosine is a powerful cytoprotective molecule, we tested whether TGF-β1 generated by isoflurane induces renal tubular ecto-5'-nucleotidase (CD73) and adenosine to protect against renal ischemia and reperfusion injury. Isoflurane induced new CD73 synthesis ...
Rodriguez L L Center for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA. - - 2013
The metabolic pathways associated with colonic motility are unknown. To identify potential metabolic targets for treatment of constipation, we examined the metabolic profile before and after a meal challenge in a cohort of children with constipation and determined its relationship with postprandial colon motility patterns. In this prospective study, 187 ...
Okabe Yasuhiro - - 2013
PURPOSE: We herein report our experience with pancreas transplantation in 26 patients at a single institution in Japan between August 2001 and December 2011. METHODS: We reviewed the medical records of 26 pancreas transplantations performed in our institute. RESULTS: The early complications (within 2 weeks) included one graft venous thrombosis, one ...
Duval K K Institute of Population Health, University of Ottawa, Ottawa, Ontario, - - 2013
Factors that influence weight gain during the menopausal transition are not fully understood. The purpose of this study was to investigate changes in energy expenditure (EE) across the menopausal transition. In all, 102 premenopausal women (age: 49.9 ± 1.9 years; body mass index: 23.3 ± 2.2 kg/m(2)) were followed for ...
Takeda Atsushi A Department of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. - - 2013
The decrease in serum zinc is linked to the hypothalamic-pituitary-adrenal (HPA) axis activation that increases the serum glucocorticoid level, indicating the importance of zinc homeostasis in physiological function. Zinc homeostasis in the brain is maintained through the blood-brain and blood-cerebrospinal fluid barriers. At young age, however, the increase in zinc ...
Hopkins Corey R CR Department of Pharmacology and Chemistry, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Vanderbilt University Medical Center, Nashville, TN 37232-6600, - - 2013
Two recent Phase II results show opposing outcomes for the potential of activators of mGlu2 in the treatment of schizophrenia. The first outcome revealed that Eli Lilly's mGlu2/3 agonist, pomaglumetad methionil (LY2140023), failed to meet the primary efficacy end point. The second report showed the mGlu2 positive allosteric modulator (PAM) ...
Pelletier Caroline C CC Université de Lyon, Lyon, - - 2013
Chronic kidney disease (CKD) is frequently associated with protein-energy wasting, a recognized strong predictive factor of mortality. Zinc α2-glycoprotein (ZAG) is a new adipokine involved in body weight control through its lipid-mobilizing activity. Here we tested whether the uremic environment in CKD could alter ZAG production by white adipose tissue ...
Pepper Ruth J RJ UCL Centre for Nephrology, Royal Free Hospital, London, UK. - - 2013
Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) commonly results in glomerulonephritis, in which neutrophils and monocytes have important roles. The heterodimer calprotectin (S100A8/S100A9, mrp8/14) is a Toll-like receptor-4 ligand found in neutrophils and monocytes and is elevated in inflammatory conditions. By immunohistochemistry of renal biopsies, patients with focal or crescentic glomerular ...
Peluffo Marina C MC Centro de Investigaciones Endocrinológicas (CEDIE-CONICET), Hospital de Niños Ricardo Gutierrez, Gallo 1330, Ciudad Autónoma de Buenos Aires, - - 2013
The small antral follicles (SAFs) from the ovarian medulla can be a potential source of oocytes for infertility patients, but little is known about their ability to yield mature oocytes. This study evaluated the response of these SAFs to a stimulatory bolus of human corionic gonadotropin (hCG) in vitro. Oocyte ...
Högberg Lars L Swedish Nuclear Power Inspectorate, Sweden. - - 2013
The root causes and impacts of three severe accidents at large civilian nuclear power plants are reviewed: the Three Mile Island accident in 1979, the Chernobyl accident in 1986, and the Fukushima Daiichi accident in 2011. Impacts include health effects, evacuation of contaminated areas as well as cost estimates and ...
Sakai Takashi T Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, 565-0871, Suita, Japan. - - 2013
Modular acetabular reconstructive cups have been introduced in an attempt to offer initial rigid fixation by iliac lag screws and ischial pegs, to support bone grafts with a flanged metal socket, and to restore original hip center in acetabular revision. The purpose of this study was to clarify minimum ten ...
Hein Rebecca R Unit of Genetic Epidemiology, Division of Cancer Epidemiology (C020), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, - - 2013
Menopausal hormone therapy (MHT) is associated with an elevated risk of breast cancer in postmenopausal women. To identify genetic loci that modify breast cancer risk related to MHT use in postmenopausal women, we conducted a two-stage genome-wide association study (GWAS) with replication. In stage I, we performed a case-only GWAS ...
Merkley Eric D ED Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, - - 2013
Chemical cross-linking of proteins followed by proteolysis and mass spectrometric analysis of the resulting cross-linked peptides provides powerful insight into the quaternary structure of protein complexes. Mixed-isotope cross-linking (a method for distinguishing intermolecular cross-links) was coupled with liquid chromatography, ion mobility spectrometry and mass spectrometry (LC-IMS-MS) to provide an additional ...
Martín Miguel M Department of Medical Oncology, Instituto de Investigación Sanitaria Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid, Spain. - - 2013
To identify a group of patients who might benefit from the addition of weekly paclitaxel to conventional anthracycline-containing chemotherapy as adjuvant therapy of node-positive operable breast cancer. The predictive value of PAM50 subtypes and the 11-gene proliferation score contained within the PAM50 assay were evaluated in 820 patients from the ...
Rule Andrew D AD Division of Nephrology and Hypertension, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota 55905, USA. - - 2013
Chronic kidney disease risk factors may associate with the estimated glomerular filtration rate (eGFR) differently than with the measured GFR. To examine this, we evaluated 1150 patients (mean age 65 years) in two community cohorts for risk factors, measured GFR by iothalamate clearance, and eGFR based on creatinine (Cr), cystatin ...
Gattepaille L M LM Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, - - 2013
Reconstructing historical variation of population size from sequence and single-nucleotide polymorphism (SNP) data is valuable for understanding the evolutionary history of species. Changes in the population size of humans have been thoroughly investigated, and we review different methodologies of demographic reconstruction, specifically focusing on human bottlenecks. In addition to the ...
Göksun Tilbe T Temple University, Philadelphia, PA, USA. - - 2013
Gestures are common when people convey spatial information, for example, when they give directions or describe motion in space. Here, we examine the gestures speakers produce when they explain how they solved mental rotation problems (Shepard and Meltzer in Science 171:701-703, 1971). We asked whether speakers gesture differently while describing ...
Serres Sébastien S Department of Oncology, CR-UK/MRC Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, - - 2013
Interferon-β (IFN-β) drugs are considered to derive their beneficial effects on multiple sclerosis (MS) progression via their antiinflammatory properties, but the precise mechanism of action remains unclear. Here, we sought to discover how IFN-β impacts on inflammation-associated aggravation of MS-like lesions in rat. Animals with dormant focal experimental allergic encephalomyelitis ...
Swenson-Fields Katherine I KI Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, - - 2013
Renal M2-like macrophages have critical roles in tissue repair, stimulating tubule cell proliferation and, if they remain, fibrosis. M2-like macrophages have also been implicated in promoting cyst expansion in mouse models of autosomal dominant polycystic kidney disease (ADPKD). While renal macrophages have been documented in human ADPKD, there are no ...
Longest P Worth PW Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, 401 West Main Street, P.O. Box 843015, Richmond, VA 23284-3015, USA. - - 2013
Aerosol delivery efficiency during noninvasive ventilation (NIV) is known to be low (~10%) and is associated with poor outcomes of aerosol therapy. The objective of this study was to demonstrate the benefit of redesigning ventilation circuit components using a streamlining approach to improve aerosol delivery during nasal high flow therapy ...
Voronov Roman S RS Department of Chemical and Biomolecular Engineering, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, - - 2013
The mouse laser injury thrombosis model provides up to 0.22 μm-resolved voxel information about the pore architecture of the dense inner core and loose outer shell regions of an in vivo arterial thrombus. Computational studies were conducted on this 3D structure to quantify transport within and around the clot: Lattice ...
Steppacher Simon D SD Department of Orthopaedic Surgery, Inselspital, University of Bern, Freiburgstrasse, 3010, Bern, - - 2013
Traumatic posterior hip dislocation in adults is generally understood to be the result of a high-energy trauma. Aside from reduced femoral antetorsion, morphologic risk factors for dislocation are unknown. We previously noticed that some hips with traumatic posterior dislocations had evidence of morphologic features of femoroacetabular impingement (FAI), therefore, we ...
Lewis Richard F RF Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA. - - 2013
Damage to one vestibular labyrinth or nerve causes a central tone imbalance, reflected by prominent spontaneous nystagmus. Central adaptive mechanisms eliminate the nystagmus over several days, and the mechanisms underlying this process have received extensive study. The characteristics of vestibular compensation when the tone imbalance is presented gradually or repeatedly ...
Knights J J Department of Pharmaceutical Sciences, State University of New York, Buffalo, NY, - - 2013
We develop an information-theoretic method for gene-gene (GGI) and gene-environmental interactions (GEI) analysis of syndromes, defined as a phenotype vector comprising multiple quantitative traits (QTs). The K-way interaction information (KWII), an information-theoretic metric, was derived for multivariate normal distributed phenotype vectors. The utility of the method was challenged with three ...
Tong Mingjie M Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, - - 2013
Regeneration of synaptic connections between hair cells and spiral ganglion neurons would be required to restore hearing after neural loss. Here we demonstrate by immunohistochemistry the appearance of afferent-like cochlear synapses in vitro after co-culture of de-afferented organ of Corti with spiral ganglion neurons from newborn mice. The glutamatergic synaptic ...
Langdon Kristopher D KD Division of BioMedical Sciences, Memorial University, St. John's, Newfoundland and Labrador, - - 2013
Dementia is a major cause of morbidity in the western society. Pharmacological therapies to delay the progression of cognitive impairments are modestly successful. Consequently, new therapies are urgently required to improve cognitive deficits associated with dementia. We evaluated the effects of physical and cognitive activity on learning and memory in ...
Zanderigo Francesca F Department of Psychiatry and Behavioral Science, Stony Brook University, New York, New York 11794-8101, USA. - - 2013
Reference region (RR) approaches (RRAs) for positron emission tomography (PET) brain studies aim to obtain full quantification without arterial input function (IF) sampling, an invasive and costly procedure. Although they need a reliable RR and are only able to estimate the nondisplaceable binding potential (BPND), RRAs are widely used. If ...
Newcombe Virginia F J VF Division of Anaesthesia, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK. - - 2013
Traumatic brain injury (TBI) is often exacerbated by events that lead to secondary brain injury, and represent potentially modifiable causes of mortality and morbidity. Diffusion tensor imaging was used to characterize tissue at-risk in a group of 35 patients scanned at a median of 50 hours after injury. Injury progression ...
Park Chul-Hyun CH Department of Orthopaedic Surgery, Yeungnam University Hospital, Daegu, South - - 2013
The purpose of this study was to compare the results of hallux valgus surgery between feet fixed with Kirschner wires and those fixed with a plate and screws. Between December 2008 and November 2009, 53 patients (62 feet) were treated with proximal chevron osteotomy and distal soft tissue procedure for ...
Aguilar Enzo E Instituto de Neurociencias de Castilla y León, Universidad de Salamanca, Salamanca, - - 2013
Medial olivocochlear efferent neurons can control cochlear frequency selectivity and may be activated in a reflexive manner by contralateral sounds. The present study investigated the significance of the contralateral medial olivocochlear reflex (MOCR) on human psychoacoustical tuning curves (PTCs), a behavioral correlate of cochlear tuning curves. PTCs were measured using ...
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