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Results 251 - 300 of 1921
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Bianchi Marco - - 2013
OBJECTIVES: To examine the trends of open and laparoscopic partial nephrectomy and radical nephrectomy according to sociodemographic and tumor characteristics. METHODS: Using the Surveillance, Epidemiology, and End Results Medicare-linked database, 6024 patients diagnosed with T1a renal cell carcinoma were abstracted. Multivariable logistic regression analyses were used for prediction of open ...
Gradl Georg - - 2013
BACKGROUND: The aim of this study was to compare non-bridging external fixation to palmar angular stable plating with respect to radiological outcome, wrist function, and quality of life. METHODS: One hundred and two consecutive patients (mean age: 63 years) were enrolled in the study. Fifty-two patients were randomized for plate osteosynthesis ...
Graham Simon M - - 2013
PURPOSE: The overall incidence of periprosthetic femoral fractures (PPF) is between 0.1 and 6 % of all total hip arthroplasties. Locking compression plates (LCP) have been used for the treatment of Vancouver B1 PPFs with variable results. The aim of this study is to examine the literature on locking plate failure ...
Jain Sameer - - 2013
PURPOSE: Major pelvic injuries resulting from high-energy trauma require emergency hospital treatment, and part of the initial management includes mechanical stabilisation of the pelvis. Controversies include binder position, use in lateral compression injuries and application during radiological assessment. We present the results of a survey of both emergency department and ...
Gisbert Javier P - - 2013
Patients with IBD are at increased risk of infection, in part owing to the disease itself, but mostly because of treatment with immunosuppressive drugs. Although many of these infections are vaccine-preventable, vaccination coverage in patients with IBD is extremely low. The vaccine strategies examined in this Review are based on ...
Kostek John - - 2013
Previous research has shown mixed results regarding the effects of cognitively draining tasks, sometimes reporting that the depletion of cognitive resources increases risk taking and other times reporting that depletion leads to increases in risk aversion. Additionally, evidence has been provided demonstrating that both winning and losing can increase future ...
Conaglen Paul J - - 2013
INTRODUCTION: Various techniques have been described to try and reduce the rate of anastomotic leak following pancreaticoduodenectomy, which remains a challenge for pancreatic surgeons worldwide. We outline a technique to reinforce the pancreatic anastomosis with a double layer of fibrin glue between suture lines. METHODS: Our technique for pancreatic anastomosis ...
Niranjan Rituraj - - 2013
Significant bodies of evidences have shown different mechanisms known to be the etiological cause of Alzheimer's disease (AD) involving amyloid-beta protein accumulation, chronic inflammatory reactions, oxidative stress, proteasome inhibition, and high-cholesterol level, but the presize etiology of AD still remains enigmatic. Recent studies indicate that these mechanisms seem to be ...
Chang Le - - 2013
Accurate computational estimate of the protein-ligand binding affinity is of central importance in rational drug design. To improve accuracy of the molecular mechanics (MM) force field (FF) for protein-ligand simulations, we use a protein-specific FF derived by the fragment molecular orbital (FMO) method and by the restrained electrostatic potential (RESP) ...
Zenclussen Ana Claudia - - 2013
It has long been believed that there is no immune interaction between mother and conceptus during pregnancy. This concept changed after evidence was provided that the maternal immune system is aware of the semiallogeneic conceptus and develops strategies to tolerate it. Since then, finely regulated mechanisms of active tolerance toward ...
Molineris Ivan - - 2013
Polymorphisms in regulatory DNA regions are believed to play an important role in determining phenotype, including disease, and in providing raw material for evolution. We devised a new pipeline for the systematic identification of functional variation in human regulatory sequences. The algorithm is based on the identification of SNPs leading ...
Ferro Mark A - - 2013
The objective of this study was to examine the factor structure and longitudinal measurement invariance of the Center for Epidemiological Studies Depression Scale (CES-D). The population-based sample included 347 adult women who had children participating in the Health-related Quality of Life in Children with Epilepsy Study. Longitudinal confirmatory factor analysis ...
Wu Yi-Jen - - 2013
A 48-year-old man presented with episodic paraplegia and stiffness of hands, face, and tongue, along with eyelid myotonia when exposed to cold temperature, which he had since childhood. Eyelid myotonia was evoked either by exposure to cold weather (video on the Neurology® Web site at www.neurology.org and figure 1) or ...
Hwang Seung Jun - - 2013
Core@shell electrocatalysts for fuel cells have the advantages of a high utilization of Pt and the modification of its electronic structures toward enhancement of the activities. In this study, we suggest both a theoretical background for the design of highly active and stable core@shell/C and a novel facile synthetic strategy ...
Incerti Parenti S - - 2013
OBJECTIVES: To test the reliability of 4 different methods of measuring maxillary canine inclination (CI) on panoramic radiographs, and to determine whether examiner experience level influenced these measurements under ideal experimental conditions. SETTING AND SAMPLE POPULATION: The sample consisted of 20 high-quality panoramic radiographs obtained under standardized conditions using the ...
Hosen Naoki - - 2013
Multiple myeloma (MM) is characterized by the clonal expansion of malignant plasma cells. As in other cancers, MM plasma cells are thought to be derived from MM-initiating cells, although these remain unidentified. MM patients harbor phenotypic CD19(+) B cells expressing the immunoglobulin gene sequence and the idiotype unique to the ...
Meireles Catarina - - 2013
The adaptive flexibility of bacteria largely contributes to the emergence of antibiotic resistance, eventually leading to the predictable failure of current antimicrobial therapies. It is of utmost importance to improve current approaches and implement new ways to control bacterial growth and proliferation. A promising strategy lies in unraveling the antimicrobial ...
Oseguera Montiel David - - 2013
Brucellosis is a major constraint for small-scale goat farming systems in Mexico. This study estimated the prevalence of testing positive to brucellosis and identified and quantified risk factors in goats from small-scale farms of Michoacán that had participated in a brucellosis campaign (i.e. vaccination, serological testing, culling and awareness) and ...
Lee Je-Hwan - - 2013
Two DNA methyltransferase inhibitors, azacitidine and decitabine, are currently approved for the treatment of myelodysplastic syndrome (MDS). Choosing between these drugs is an important practical issue. In this retrospective study, patients receiving AZA-7d (azacitidine 75 mg/m(2) subcutaneously × 7 days, n = 75) or DEC-5d (decitabine 20 mg/m(2) intravenously × 5 days, n = 74) were compared. The rates of hematologic response ...
Severo Cecília Bittencourt - - 2013
Paracoccidioidomycosis (PCM) is an endemic disease restricted geographically to Latin America. Brazil accounts for about 80 % of the reported cases, and lungs are most frequently affected. A suggestive radiograph of PCM may only be seen late in the course of the disease. At the beginning, it mimics tuberculosis. On the ...
Ohashi Toshimitsu - - 2013
The activation of oncogenic signaling pathways induces the reprogramming of glucose metabolism in tumor cells and increases lactic acid secretion into the tumor microenvironment. This is a well-known characteristic of tumor cells, termed the Warburg effect, and is a candidate target for anti-tumor therapy. Previous reports show that lactic acid ...
Kaplan Celia P - - 2013
PURPOSE: Patient participation in cancer clinical trials is imperative to the advancement of medical science. Physicians play an important role in recruitment by discussing clinical trials with their cancer patients. Patient-physician discussion is influenced by many factors relating to the physician, the patient, and the healthcare system. METHODS: Physicians selected ...
Weber Béatrice - - 2013
PURPOSE: A prospective phase II multicenter study was performed in two steps in paclitaxel-treated ovarian cancer patients in France. A French version of the four-item Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) questionnaire was validated. This was then used to evaluate neurotoxicity in relation to erythropoietin treatment. METHODS: Patients ...
Heiskanen Marja A - - 2013
Chemical-genomic and genetic interaction profiling approaches are widely used to study mechanisms of drug action and resistance. However, there exist a number of scoring algorithms customized to different experimental assays, the relative performance of which remains poorly understood, especially with respect to different types of chemogenetic assays. Using yeast Saccharomyces ...
Golubnitschaja Olga - - 2013
ABSTRACT: Breast cancer is a multifactorial disease. A spectrum of internal and external factors contributes to the disease promotion such as a genetic predisposition, chronic inflammatory processes, exposure to toxic compounds, abundant stress factors, a shift-worker job, etc. The cumulative effects lead to high incidence of breast cancer in populations ...
Zhang Wei - - 2013
Abstract 5-bromotetrandrine (BrTet), a multidrug resistant (MDR) candidate modulator, is a potential candidate for use in cancer therapy when combined with anticancer agents such as daunorubicin (DNR), paclitaxel. Purpose: To investigate the mechanism of reversal of P-glycoprotein (P-gp)-mediated MDR by BrTet and involvement of c-Jun N-terminal Kinase (JNK)/c-Jun signaling pathways ...
Wu Yao - - 2013
In force field parameter development using ab initio potential energy surfaces (PES) as target data, an important but often neglected matter is the lack of a weighting scheme with optimal discrimination power to fit the target data. Here, we developed a novel partition function-based weighting scheme, which not only fits ...
Parnetti Lucilla - - 2013
Clinical diagnosis of Parkinson disease (PD) is difficult in early stages of disease, with high risk of misdiagnosis. The long preclinical phase of PD provides the possibility for early therapeutic intervention once disease-modifying therapies have been developed, but lack of biomarkers for early diagnosis and monitoring of disease progression represents ...
Zhang Haiwen - - 2013
OsERF3 is a transcriptional repressor with an ethylene-responsive element-binding factor-associated amphiphilic repression (EAR) motif (F/LDLNxxP), which transcriptionally represses the ethylene emission and drought tolerance in rice. However, its molecular mechanism to explore repression function remains unknown. Here, we first revealed that the expression of OsERF3 was induced by drought, salt, ...
Yan Hanfei - - 2013
For scanning x-ray microscopy, many attempts have been made to image the phase contrast based on a concept of the beam being deflected by a specimen, the so-called differential phase contrast imaging (DPC). Despite the successful demonstration in a number of representative cases at moderate spatial resolutions, these methods suffer ...
Liu Wu - - 2013
In this work, sub-microlitre droplets were generated by gravity and electrostatic attraction using a capillary tube. The parameters affecting the sizes and frequency of the droplets were investigated. The volume of droplets could be controlled in the range from 0.7 μL to 2.4 μL and the time interval from 15 ...
Marinho M A T - - 2013
The internal transcribed spacer 2 (ITS2) of the eukaryotic ribosomal DNA (rDNA) cluster plays an essential role in processing of the ribosomal RNA, which is primarily accomplished by the secondary structures acquired by the molecule after transcription. Two possible structural conformation models have been proposed for the ITS2 region, the ...
Li Xiufeng - - 2013
Measurements of blood flow in the human hippocampus are complicated by its relatively small size, unusual anatomy and patterns of blood supply. Only a handful of arterial spin labeling (ASL) MRI articles have reported regional cerebral blood flow (rCBF) values for the human hippocampus. Numerous reports have found heterogeneity in ...
Gijsbers Linda - - 2013
Since beneficial effects related to tomato consumption partially overlap with those related to PPARγ activation, our aim was to test extracts of tomato fruits and tomato components, including polyphenols and isoprenoids, for their capacity to activate PPARγ using the PPARγ2 CALUX reporter cell line. Thirty tomato compounds were tested; seven ...
Bacchetta Justine - - 2013
ABSTRACT: BACKGROUND: Idiopathic juvenile osteoporosis (IJO) is a rare condition of poorly understood etiology and pathophysiology that affects otherwise healthy children. This condition is characterized clinically by bone pain and vertebral fractures; spontaneous recovery is observed after puberty in the majority of cases. Although decreased trabecular bone turnover has been ...
Ali Mohammad Javed - - 2013
Abstract Aims: To study the efficacy of a new technique of single self-linking silicone stent exclusively in pediatric external dacryocystorhinostomy (DCR) and to report the new use and advantages of endoscopic guidance for the same. Material and methods: Prospective interventional case series, including 11 eyes of ten patients with nasolacrimal ...
Shmeliov Aleksey - - 2013
Structural characterization of 2D nanomaterials is an important step towards their future applications. In this work we carried out imaging and structural analysis of 2D h-BN produced by chemical-exfoliation, emphasizing the stacking order in few-layer sheets. Our analysis, for the first time has shown conclusively that non-bulk stacking can exist ...
Görgens Sven W - - 2013
Abstract Follistatin-like protein 1 (Fstl1) is a secreted glycoprotein of the follistatin family. Fstl1 is secreted by C2C12 cells, and Akt1 over-expression in skeletal muscle leads to its induction in muscle and increased circulating levels. So far, secretion of Fstl1 by human myotubes and the effect of exercise on its ...
Bevilacqua Francesca - - 2013
Abstract Objective: To evaluate emotional distress, depression and quality of life in parents of infants with severe congenital heart disease (CHD) during their first hospitalization. Methods: A pilot study for 38 parental couples of infants with CHD hospitalized within the three months of life. Parents filled up three self-administered questionnaires. ...
Mori Shinichiro - - 2013
In this review article we emphasize the importance of "imaging" and "image guidance" in advanced particle therapy from a clinical point of view. Although the image-guided radiotherapy (IGRT) technology used for photon and particle therapy is closely similar, the focus of its application in the two modalities differs. Here, we ...
Suárez Carlos - - 2013
The definitive universally accepted treatment for carotid body tumors (CBT) is surgery. The impact of surgery on cranial nerves and the carotid artery has often been underestimated. Alternatively, a few CBTs have been followed without treatment or irradiation. The goal of this study is to summarize the existing evidence concerning ...
He Yi-San - - 2013
The use of an accelerometer as a gas detector in gas chromatography (GC) is described for the first time. A milli-whistle was connected to the outlet of the GC capillary. When the eluted and GC carrier gases pass through the capillary and milli-whistle, a sound is produced. After a Fast ...
Xie Feng - - 2013
BACKGROUND AND OBJECTIVE: Osteoarthritis (OA) is a highly prevalent and chronic condition characterized by pain and physical disability. Currently, many treatments are available, and they primarily target pain relief. The objectives of this study were to systematically review economic evaluations for pharmaceutical management of OA pain and to provide methodological ...
Morken Nils-Halvdan - - 2013
OBJECTIVE: To estimate the risk of operative delivery according to maternal pre-pregnant body mass index (BMI) and gestational weight gain. DESIGN: Population-based pregnancy cohort study. SETTING: The Norwegian Mother and Child Cohort Study. SAMPLE: Term singleton deliveries in cephalic presentation, excluding preeclampsia, chronic hypertension, diabetes, gestational diabetes and placenta previa ...
Kong Song-Zhi - - 2013
The accumulation of extracellular amyloid-β peptide (Aβ) has been considered as one of the important causes of Alzheimer's disease (AD), the most prevalent form of dementia. Hydroxysafflor yellow A (HSYA), a major active chemical component isolated from Carthamus tinctorius L., has been shown to possess neuroprotective actions in various ischemic ...
Pijls Nico H J - - 2013
Fractional flow reserve (FFR) has become an increasingly important index for decision making with respect to revascularization of coronary artery stenosis. It is the gold standard to indicate whether a particular stenosis is responsible for inducible ischemia and it is generally accepted that a stenosis with an ischemic value of ...
O'Shea John J - - 2013
The molecular biology revolution coupled with the development of monoclonal antibody technology enabled remarkable progress in rheumatology therapy, comprising an array of highly effective biologic agents. With advances in understanding of the molecular nature of immune cell receptors came elucidation of intracellular signalling pathways downstream of these receptors. These discoveries ...
Souza Rosinei Aparecida - - 2013
Although Brazil has recently reached the position as the second largest producer of genetically modified soybean [Glycine max (L.) Merr.], there are few reports on the effects of transgenic crops and the associated use of specific herbicides on soil microbial communities, both under the edaphoclimatic conditions in Brazil, and in ...
Koh Hyun Seung - - 2013
Metal-organic frameworks (MOFs) have emerged as promising materials for carbon capture applications due to their high CO(2) capacities and tunable properties. Amongst the many possible MOFs, metal-substituted compounds based on M-DOBDC and M-HKUST-1 have demonstrated amongst the highest CO(2) capacities at the low pressures typical of flue gasses. Here we ...
Rachele Cagliani - - 2013
The THBS4 gene encodes a glycoprotein involved in inflammatory responses and synaptogenesis. THBS4 is expressed at higher levels in the brain of humans compared to non-human primates, and the protein accumulates in β-amyloid plaques. We analysed THBS4 genetic variability in humans and show that two haplotypes (hap1 and hap2) are ...
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